Alpha GPC for Strength CONFIRMED: 600mg/day for Legs!

Alpha GPC

A new study published in the Journal of the International Society of Sports Nutrition finds that 600mg daily of Alpha GPC significantly improves leg strength. Image courtesy Chemi Nutra.

Choline supplements are frequently used by athletes, bodybuilders, and even students to increase focus, cognition, and memory formation. The problem with certain forms of choline supplements is that they are not absorbed all the well by the body.

However, alpha-glycerylphosphorylcholine (Alpha GPC) is one of the forms that is highly bioavailable and readily absorbed by the body. Several studies have been done on this form of choline in regards to cognitive improvement, Growth Hormone output, and power development.[2,3,4]

We often compare the two high-end choline supplements, Alpha GPC vs. Citicoline (CDP Choline), usually siding on citicoline end of the argument because we ‘feel’ it more. Today that might have to change.

Reason being, not much has been studied in the way of Alpha GPC’s role in improving strength levels… until now. Could a brain boosting nootropic really help improve your strength levels in the weight room, translating to better performance on the field of competition?

A new study published in the Journal of the International Society of Sports Nutrition investigates the effects of Alpha GPC on strength and performance.

The Study

Alpha GPC Study

13 college-age males were recruited for a 6 day trial to test the effects of 600mg of Alpha GPC on upper and lower strength.[1]

Thirteen college-age males were recruited for a double-blind, placebo-controlled crossover study lasting six days.[1] Participants were administered 600mg each day of Chemi Nutra’s AlphaSize® Alpha-GPC or placebo. Subjects were also asked to follow their normal day-to-day routine and not add or remove anything from their typical diet or supplementation regimen.

Following supplementation, the participants were subjected to both upper body and lower body isometric strength tests. Upper body testing consisted of performing push up type movement against a high-frequency load cell. Lower body testing involved the use of a squat cage where participants performed an isometric mid thigh pull.

After a 1-week washout period, the males repeated the trial with the other treatment (this is the crossover side of things).

The Results

Mid Thigh Pull Results

Results showed statistically significant improvements on the isometric mid-thigh pull in the test subjects using 600mg of Alpha GPC.[1]

The greatest improvements were seen in lower body strength results, where the isometric mid-thigh pull peak force significantly increased from initial testing baseline compared to placebo. Unfortunately, the upper body results were not statistically significant, but they did trend “towards greater change from baseline force production.”[1]

Regarding the discrepancy in results for upper body testing, researchers said it may be due to a high variability of upper body strength among the participants, which could have limited their statistical impact. Nevertheless, the researchers maintain there were improvements, and the good news is that further studies with more participants are coming, which may smooth that out and give even better data.

The group of researchers further commented,

“The results of the study suggest that A-GPC is effective at increasing lower-body force production after six days of supplementation. Given that, in many sports, it is understood that a very small change in performance, often times less than 2%, can significantly affect outcomes, it is important to note that the six days of A-GPC resulted in greater than a 3% increase in lower-body isometric strength.”[1]

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The Road Ahead

Alpha-GPC Upper Body Results

The results from the upper body tests were not statistically significant, but did trend towards improvements in pushing strength.[1]

After seeing the study for ourselves, Team PricePlow reached out to Dr. David Bellar, Ph.D. RSCC*D, CSCS*D, director of the School of Kinesiology at the University of Louisiana at Lafayette regarding future trials involving Alpha GPC.

During our communications, Dr. Bellar mentioned that, “A larger trial is currently underway in our lab where we plan to study 48 individuals with two different doses of A-GPC compared to Caffeine.”[1]

Additionally, Dr. Bellar also stated that within the next six months, his team will be investigating tart cherry products effects on human performance. We’ve definitely been seeing tart cherry trending in products, so this lab is up to good things.

Products that Contain Alpha GPC

Below are the blog posts tagged with Alpha GPC. Note, however, that nearly none of them contain full 600mg doses of the ingredient, but they’re usually a great start, and then you can add a bit more on your own:

Wrap Up

We’ve always loved choline-based supplements – but mostly for the “mind-muscle” feel they provide. Now we know that there’s much more going on than that!

In fact, a few of our top-rated pre workout supplements contain it already – but we’ll see what brand is first to respond with this clinical (albeit kind of expensive) dose!

AlphaSize Alpha GPC

Expect to see more AlphaSize Alpha-GPC in pre workouts in 2016!

Anyway, every athlete and average gym rat is looking for safe, natural ways to increase their performance in the weight room and on the field. It doesn’t matter if you are a weekend warrior or an Olympic athlete, there’s an innate desire among us all to get bigger, faster, and stronger.

Sure we all know about creatine, beta alanine, betaine, etc. but where are those hidden gems that not everyone may be using?

Initial studies involving Alpha GPC show some promising results for improving power and strength levels, and future studies will hopefully back this up along with an “ideal” dose.

Make sure to stay tuned to PricePlow for any further developments regarding Alpha GPC studies and for Dr. Bellar’s larger trial on it in the coming months.

Alpha-GPC - Deals and Price Drop Alerts

Get Price Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is a biohacker with extensive experience in supplementation and dietary modification, whose personal expertise stems from several "n=1" experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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  1. Bellar D, LeBlanc NR, Campbell B; “The effect of 6 days of alpha glycerylphosphorylcholine on isometric strength”; J Int Soc Sports Nutr. 2015; 12(1):42; Retrieved from
  2. Ziegenfuss T, Landis J, Hofheins J. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. Journal of the International Society of Sports Nutrition. 2008;5(Suppl 1):P15. doi:10.1186/1550-2783-5-S1-P15.
  3. De Jesus Moreno Moreno M; Cognitive improvement in mild to moderate Alzheimer’s dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial . Clin Ther. (2003)
  4. Parnetti L, Amenta F, Gallai V; Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data . Mech Ageing Dev. (2001)

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