Chris Bumstead’s CBUM Thavage Pre Workout: A Pre Fit For Thavages

In Episode #052 of the PricePlow Podcast, we recently interviewed the leadership team at Raw Nutrition, which includes Matt Jansen, Dr. Domenic Iacovone, and their newest partner, Chris Bumstead. They detailed how Classic Physique Mr. Olympia was joining the team, and discussed the CBUM product line launch, which is starting with two products – CBUM ISO-Protein and CBUM Thavage Pre Workout.

The backstory: a pre workout that gives back

RAW Nutrition Thavage Pre Workout

The RAW Nutrition x CBUM Thavage Pre Workout is here, and it’s insanely well-dosed on all angles!

The interview explains that Chris, a former Jacked Factory sponsored athlete, was about to release this line with them, when Matt and Dom made the move to add him as an equity partner. The split was amiable, so rather than scrap the original CBUM project, they’re releasing it through Raw Nutrition.

However, to keep things fair for the first run, both companies will be donating profits to canine-related charities in the USA and Canada, since Chris is such a huge dog lover.

With that covered, we can get into the pre workout:

Train like The Thavage You Are with CBUM’s New Pre Workout

Thavage Pre Workout has 40 scoops with 20 full servings. If you two scoop it, you’ll get a blend of 305 milligrams caffeine alongside efficacious doses of numerous ingredients including citrulline, creatine monohydrate, betaine, taurine, and of course, beta alanine.

Love them beta alanine tingles

In the podcast linked above, we learn that Chris personally loves the beta alanine tingles, so you shouldn’t be surprised to see it in his pre. But what we’re also excited to see are some extra energy and focus ingredients from tyrosine, synephrine, and alpha-GPC — this is a very well-rounded pre workout, so we’ve got a lot of work to do below.

The ingredients are covered below, but first, sign up for PricePlow’s Raw Nutrition alerts so we hit you up as news develops:

RAW Nutrition CBUM Thavage Pre-Workout – Deals and Price Drop Alerts

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Raw Nutrition CBUM Thavage Pre Workout Ingredients

Below we explain what we get in a two scoop serving of the Thavage – but with 16 well-dosed ingredients, we can’t go insanely deep on each one, so we briefly provide the main purpose of each ingredient first:

  • L-Citrulline – 6000 mg

    Raw Nutrition CBUM Thavage Pre Workout

    A better question is to ask what doesn’t this pre workout have?!

    Main Purpose: Nitric oxide pumps.

    It’s not a modern pre workout without an efficacious dose of L-Citrulline, which is used to produce more L-arginine, which then goes on to increase nitric oxide (NO) levels,[1] and it actually works better than supplementing arginine itself![2-4]

    With more NO production, we get a vasodilation effect (widened blood vessels), improving blood flow that not only improves nutrient delivery, but gives us pumps! It also helps us with better ATP production, leading to improved work output and improved recovery.[5-7] Athletes also notice lower perceived exertion and less soreness as well.[8]

    This is twice the clinical dose, where we normally want to see at least 3 grams of citrulline (or 6 grams of citrulline malate).[9]

    Off to a great start, as expected.

  • Beta Alanine – 3200 mg

    Main Purpose: Endurance.

    As we learned in our podcast with Chris, he’s all about the beta alanine tingles, and that’s a great thing, because if you can handle this ingredient, you’ll get improved production of carnosine when combined with the essential amino acid L-histidine (which is found in Raw EAA).[10,11] Carnosine then goes on to buffer lactic acid in muscles, and that prolongs muscular endurance.

    Beta Alanine Meta Analysis

    The 2016 meta analysis showed who beta alanine may work best for[12] – and it’s generally for endurance and mid-distance activities.

    This has all been demonstrated with numerous studies, and we have two large meta analyses (one published in 2012 on 360 participants[12] and the other published in 2016 on 1461 participants[13]) and the end result is that researchers believe that any exercise ranging from 30 seconds to 10 minutes long stands to benefit greatly from beta alanine.[13]

    Additionally, we like to point out some strong synergy with creatine,[14] which we also have in Thavage pre.

    On those tingles…

    The tingling sensation that Chris loves is known as paresthesia, but is known to be non-toxic — a 2019 safety study concluded that beta alanine “does not adversely affect those consuming it”.[15]

  • Creatine Monohydrate – 3000 mg

    Main Purpose: Do-it-all ergogenic muscle builder.

    An ergogenic ingredient we began missing from well-rounded pre workout supplements, it’s tough to dispute creatine at this point. By way of helping your body generate more ATP,[16-20] creatine can has numerous benefits, most of which are not only demonstrated in studies, but replicated and bolstered by meta-analyses:

    Chris Bumstead Raw Nutrition

    Congratulations to Chris, now a partner at Raw Nutrition!

    • Improved power[21,22]
    • Weight gain,[22]
    • Lean mass gains,[22-26]
    • Better sprint speed,[27-29]
    • Increased hydration,[30]
    • Reduced fatigue,[31-34]
    • Improved overall well-being[35-37]
    • Cognitive improvements (in vegans/vegetarians)[38,39]
    • Slightly improved testosterone levels[16,40-43]
    • Greater bone mineral density (especially in non-meat eaters)[25]

    There’s simply too much to dispute with this ingredient. The real question is how much you need, and that depends on your diet, since there’s creatine in meat. The safe bet is to get 3-5 grams in every day, which is where you’ll find Thavage Pre.

  • Betaine Anhydrous – 2500 mg

    Main Purpose: Ergogenic muscle builder.

    Trimethylglycine

    From the MEN’s study: The arms don’t lie! Here’s one place where placebo doesn’t rule: arm size! Betaine built bigger arms… in trained subjects![44]

    Not to be outdone by creatine, we also have betaine, also known as trimethylglycine or TMG. It works like creatine, but whereas creatine is a phosphate donor, betaine is a methyl donor that can reduce homocysteine levels,[45] which means Thavage Pre can provide more of what your body may need when training hard.

    Betaine is also an osmolyte, helping to regulate cellular fluids, which bolsters their strength[44,46] and helps protect from heat shock.[47]

    After several years of research demonstrating performance-based benefits from betaine,[48-53] landmark studies were published in 2013 and 2014 showing that 2.5 grams of betaine per day led to 5.3 pounds of lean muscle mass gained and 6.4 pounds of fat mass lost, which meant a 3% body fat reduction in just six weeks![44,54] Arm size gains were made too!

    The same team of researchers also showed fat loss effects in a women-only study, once again at 2.5 grams per day,[55] the dosage we have here.

  • Taurine – 2000 mg

    Main Purpose: Hydration-driven endurance.

    Taurine is a great continuance for betaine, since it’s also an osmolyte ingredient shown to improve endurance as it can reduce oxidative stress, boost muscle contractions through improved calcium signaling, and even helps with better fat digestion.[56-59]

    We generally appreciate it most for its endurance boost, where a 2018 meta analysis showed that 1-6 gram doses help even on the first use.[58]

    CBUM Raw Series

    The CBUM Series at Raw Nutrition is off to a great start

    Additionally, there are some cognitive benefits[57] and taurine even helps with the nitric oxide system.[59] With all this included, it’s no surprise that it’s in most pre workouts anymore.

  • GlycerSize (Glycerol Powder 65%) – 2000 mg

    Main Purpose: Hydration-driven pumps.

    As we learned from our interview with Chris, both Chris and Matt really enjoy the added pumps from Raw Nutrition Pump2, which is a raw glycerol powder. Unsurprisingly, 2 grams are in Thavage Pre as well.

    Glycerol Time to Fatigue

    Last longer (bigger time-to-fatigue), hydrate better, and subsequently lose more weight due to longer endurance? Glycerol is a must-try for endurance athletes.[62]

    Consider this our third hydration-driving ingredient in a row (we’ll also have some coconut water powder to add to that later), and this one is a sugar alcohol that can boost the body’s total water volume and improve water retention.[60]

    Scientists call this hydrating effect from glycerol “hyperhydration”,[61] and when taken with enough water, we see improvements to endurance as well as heat protection benefits.[62-64]

    Some of the studies even show reduced urine output, as you’re keeping your hydration and not having to urinate in the middle of your workout as much. Small things like that are important when you’re training for Mr. Olympia!

  • L-Tyrosine – 1000 mg

    Main Purpose: Focus.

    Now we get into some focus and energy, starting with L-tyrosine, a precursor for some of our favorite neurotransmitters like norepinephrine and dopamine, than then go on to increase focus and alertness.[65] By taking L-tyrosine, we drive the sympathetic nervous system with a few more of these neurotransmitters, igniting the fight in our “fight or flight” mode.

    Raw Nutrition CBUM Iso Protein

    After this, we’ll also have to discuss the new Raw Nutrition CBUM Iso Protein

    If you’re training as hard as Chris, you know that sleep is critical, but sometimes we come in a bit deprived after a rough night. Good news is that researchers have repeatedly demonstrated how great L-Tyrosine works for cognitive improvements when in a sleep-deprived state![66,67]

    Here, we have a 1 gram dose, which is where we like to see it, and Chris is using straight L-tyrosine, our preferred form.

  • Agmatine Sulfate – 1000 mg

    Main Purpose: Pumps.

    Not as many pre-workouts use this nitric oxide amplifying ingredient anymore, and that’s a shame because it’s one we love. CBUM knows better though — agmatine sulfate is a metabolite of L-arginine that functions as an arginase inhibitor.[68] This means it prevents arginase from breaking down our arginine (which was boosted by L-citrulline above), keeping more arginine and thus more nitric oxide around longer.

    We consider this a “defensive” ingredient, and love to have a few of them in the stack alongside the primary components. However, it’s not all defensive — agmatine can also boost nitric oxide synthase,[69] so we do get a bit of nitric oxide production as well.

    Even better, this is one of those ingredients that will be amplified by AstraGin below (36% in the case of agmatine), so Chris and Raw Nutrition found a way to make it even better. More on that below.

  • Coconut Fruit Water Powder – 500 mg

    Main Purpose: Hydration.

    A fourth hydration agent (behind betaine, taurine, and glycerol), coconut water powder has been shown to help improve total body hydration and help the body retain more water with its electrolyte components.[70] When comparing it to carbohydrate-based electrolyte beverages, researchers showed that coconut water restores hydration just as well.[71] Here, we’re stealing the coconut from those products, but you’ll be adding your own water!

  • Alpha-GPC (Alpha-Glyceryl Phosphoryl Choline 50%) – 400 mg

    Main Purpose: Focus.

    Thavage Pre Workout

    Thtop. Thavage Time. We love Chris’ down-to-earth sense of humor.

    We’ve added focus by boosting neurotransmitters through L-Tyrosine, but now it’s time to augment the brain by increasing choline — and one of the best ways to do that is with Alpha-GPC.

    When we add a high-quality choline source like Alpha-GPC, we provide our brains and bodies more substrate to produce acetylcholine, which we refer to as “the learning neurotransmitter”. Acetylcholine is active in numerous functions, many of which are athletic-related. For instance, it’s used for both muscle contractions and for learning, and we’ve seen improved muscle output and focus from it.[72,73]

    Because of this, many will often report a better “mind-muscle connection” with alpha-GPC – so focus on those contractions, nice and slow.

    This is another one of those ingredients that plays “offense”, but it’s also boosted with Huperzine A (the “defensive” play) in this formula too.

  • Caffeine Anhydrous – 260 mg (of 305 milligrams total)

    Main Purpose: Energy.

    CBUM Thavage Pre brings 305 milligrams of total caffeine in two scoops, and 260 grams comes in the straight anhydrous form. You should know your caffeine tolerance at this point, and can decide how to scoop accordingly.

    Caffeine works by inhibiting adenosine and phosphodiesterase,[74] which will ultimately wake you up. Keeping it diet-friendly, caffeine can also boost fat oxidation a bit, providing you some fatty acids to use for energy.[75-77]

    In a little bit, we’ll detail the added 45 milligrams of caffeine that comes in a slower-release form, so you can ride the wave a bit longer.

  • L-Theanine – 150 mg

    Main Purpose: Anxiety-reducing focus.

    Raw Nutrition CBUM Series

    Get Raw. Get Thavage.

    With everything going on, it’s important to keep ourselves relatively calm in the wake of our ferocious caffeine-induced workouts. That’s where L-theanine comes in, a tea-based amino acid that’s well-known for its nootropic abilities that can lower anxiety and keep things a bit calmer.[78]

    But even better, research has demonstrated that theanine and caffeine are synergistic — together, they can improve focus and cognition more than either one can do separately.[79-81] Theanine is a great way to “take the edge off” of the caffeine, in case you’re new to a 300+ milligram dosed pre workout.

  • Bitter Orange (Citrus aurantium) Fruit Extract (6% Synephrine) – 100 mg

    Main Purpose: Energy and fat oxidation.

    Need a bit more on top of your caffeine? You’ve come to the right place, the Thavage also includes citrus aurantium standardized for a bit of synephrine.

    With this, we get a unique beta-3 adrenergic receptor agonist[82] that can increase the body’s ability to burn fat.[83,84] It increases metabolic rate and can suppress appetite, but without a blood pressure spike or heart rate increase.[82] This yields more energy for your workout.

    In addition, synephrine’s fat oxidation benefits have been shown to be synergistic with caffeine.[85]

    There are other incredible constituents inside of citrus aurantium as well,[86] such as hordenine, but we’re not sure if they’re going to be found here or not. Either way, we love this ingredient for a bit more energy on top of our caffeine.

  • Di-Caffeine Malate – 64 mg (delivering 45 mg caffeine out of 305 milligrams total)

    Chris Bumstead Raw Nutrition Ownership

    Chris Bumstead is now a partner at Raw Nutrition! Learn what’s coming back with PricePlow Podcast Episode #052.

    Main Purpose: Longer-lasting energy.

    As mentioned above, we have our second form of caffeine that brings the total dosage up to 305 milligrams. Dicaffeine malate is caffeine bound to malic acid, which takes a touch longer to metabolize, leaving a longer “energy curve” in the process.

    All of the rules of caffeine still apply,[74-77] they will just have a longer half-life so that you don’t have a “pump and dump” from standard anhydrous. Dicaffeine malate will keep the effects coming a bit longer.

  • AstraGin (Astragalus membranaceus & Panax notoginseng) Root extracts – 25 mg

    Main Purpose: Ingredient amplification.

    With so many ingredients, we have to tie them all together, and a fantastic way to do that is with the absorption amplifier AstraGin, a bioavailability-increasing ingredient made by NuLiv Science. AstraGin increases uptake of the other ingredients by upregulating various transporters and improving gut permeability.[87]

    NuLiv Science’s research has demonstrated it to improve uptake of numerous ingredients, including (but definitely not limited to) agmatine and citrulline — both of which are in CBUM Thavage Pre — as shown below:

    • AstraGin and Creatine:

      AstraGin Creatine

      AstraGin amplifies tons of ingredients, but we rarely talk about how it boosts absorption of creatine![https://docdro.id/rA01t9O]

    • AstraGin and Citrulline:

      AstraGin Citrulline

      One of AstraGin’s most popular use-cases is its ability to enhance citrulline absorption – especially right when we’d want it: during our workout![87]

    • AstraGin and Agmatine:

      AstraGin Agmatine

      On top of its creatine boosting abilities, agmatine can enhance agmatine’s absorption as well.[87]

    With a formula like this, you’d be crazy not to include AstraGin to ramp it up further. Just too many synergies to ignore.

  • Huperzine A (H. serrata) (whole herb) Extract – 100 mcg

    Main Purpose: Longer-lasting focus.

    Finally, one last ingredient to keep that focus going. Above, we mentioned that alpha-GPC is “playing offense” in boosting acetylcholine levels around. Now it’s time to play defense, just like we did with agmatine. Only this time, we’re defending acetylcholine instead of arginine.

    CBUM Thavage Pre Workout

    Read the label! It’s transcribed below

    Huperzine A is an acetylcholinesterase inhibitor, meaning that it inhibits the enzyme that breaks acetylcholine down.[88] This allows us to keep our alpha-GPC-boosted acetylcholine longer, which should allow for longer, better focus.

    Because of this effect, we’ve seen it increase cognitive function and boost learning abilities,[89] but we’ve even seen it stimulate neurogenesis,[90] which means it may help with the growth of new neurons! A perfect way to close this formula down.

Flavors available

    Read the label!

    Don’t be a bum. Train hard. Sleep harder. Don’t be a pu**y. Take two scoops. Add another plate. Love your mom. No regrets. Stay hungry. Drink your water. Fall in love. Saturdays are for the boys. Dream big. Never quit. Be honest. Take responsibility. Take risks. Dare to lead. Own your sh*t. Get Huge. Get Shredded. Lift more. Run further. Jump higher. Remember to live, laugh, and all that bullsh*t.
    Get Raw.
    Be a Thavage.

    A pre workout fit for Mr. Olympia

    Chris Bumstead Pre Workout

    What a way to launch a lineup. Up next, CBUM’s Iso-Protein!

    Now that’s how you formulate a Thavage Pre Workout. There isn’t much more to say about this — we’ve long been fans of Chris Bumstead (learn more about him in our article titled Chris Bumstead: “The Comeback Kid”) — and this formula simply rocks.

    With so many clinically dosed ingredients, and the fact that they’re all within reach without overdoing the caffeine, we couldn’t be more proud to see Chris’ partnerships blossom. Joining the dynamic duo of Matt Jansen and Dr. Dom Iacovone, now making it a trio at Raw Nutrition, tells us everything we need to know about Chris’ future in supplements: it’s bright. These formulas will not let you down.

    Check it out in our prices below, and get those Raw Nutrition news alerts from PricePlow, since we’re still yet to cover CBUM Iso-Protein next!

    RAW Nutrition CBUM Thavage Pre-Workout – Deals and Price Drop Alerts

    Get Price Alerts

    No spam, no scams.

    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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    References

    1. Bailey, SJ et al.; “l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.”; Journal of Applied Physiology; 119(4) pp. 385-395; 2015; https://journals.physiology.org/doi/full/10.1152/japplphysiol.00192.2014
    2. Schwedhelm, Edzard et al.; “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.”; British journal of clinical pharmacology vol. 65,1 (2008): 51-9.; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291275/
    3. Castillo, L, et al. “Splanchnic Metabolism of Dietary Arginine in Relation to Nitric Oxide Synthesis in Normal Adult Man.” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 1, 1 Jan. 1993, pp. 193–197; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45626/
    4. Wu, Guoyao. “Intestinal Mucosal Amino Acid Catabolism.” The Journal of Nutrition, vol. 128, no. 8, 1 Aug. 1998, pp. 1249–1252, 10.1093/jn/128.8.1249; https://academic.oup.com/jn/article/128/8/1249/4722724
    5. Giannesini B., et. al.; European Journal of Pharmacology; “Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle;” September 2011; http://www.ncbi.nlm.nih.gov/pubmed/21664351
    6. Perez-Guisado J, Jakeman PM; Journal of Strength and Conditioning; “Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness;” May 2010; http://www.ncbi.nlm.nih.gov/pubmed/20386132
    7. Hickner RC. et. al.; Medicine and Science in Sports and Exercise; “L-citrulline reduces time to exhaustion and insulin response to a graded exercise test;” 2006; http://www.ncbi.nlm.nih.gov/pubmed/16679980
    8. Rhim, Hye Chang, et al. “Effect of Citrulline on Post-Exercise Rating of Perceived Exertion, Muscle Soreness, and Blood Lactate Levels: A Systematic Review and Meta-Analysis.” Journal of Sport and Health Science, Feb. 2020, 10.1016/j.jshs.2020.02.003. https://www.sciencedirect.com/science/article/pii/S2095254620300168
    9. Sureda, Antoni, et al. “L-Citrulline-Malate Influence over Branched Chain Amino Acid Utilization during Exercise.” European Journal of Applied Physiology, vol. 110, no. 2, 25 May 2010, pp. 341–351, 10.1007/s00421-010-1509-4; https://pubmed.ncbi.nlm.nih.gov/20499249/
    10. Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    11. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    12. Hobson, R M et al. “Effects of β-alanine supplementation on exercise performance: a meta-analysis.” Amino acids vol. 43,1 (2012): 25-37. doi:10.1007/s00726-011-1200-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
    13. Saunders, Bryan, et al. “β-Alanine Supplementation to Improve Exercise Capacity and Performance: A Systematic Review and Meta-Analysis.” British Journal of Sports Medicine, vol. 51, no. 8, 18 Oct. 2016, pp. 658–669; https://bjsm.bmj.com/content/51/8/658.long
    14. Stout JR, et al; “Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold”; J Strength & Cond Research; 2006 20(4): 928−931; https://www.ncbi.nlm.nih.gov/pubmed/17194255
    15. Dolan, Eimear, et al. “A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.” Advances in Nutrition, vol. 10, no. 3, 13 Apr. 2019, pp. 452–463, 10.1093/advances/nmy115; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520041/
    16. Sheikholeslami Vatani, D., et al. “The Effects of Creatine Supplementation on Performance and Hormonal Response in Amateur Swimmers.” Science & Sports, vol. 26, no. 5, Nov. 2011, pp. 272–277, 10.1016/j.scispo.2011.07.003; https://www.sciencedirect.com/science/article/abs/pii/S0765159711001171
    17. Mujika, I., and S. Padilla. “Creatine Supplementation as an Ergogenic Aid for Sports Performance in Highly Trained Athletes: A Critical Review.” International Journal of Sports Medicine, vol. 18, no. 07, Oct. 1997, pp. 491–496, 10.1055/s-2007-972670; https://www.ncbi.nlm.nih.gov/pubmed/9414070
    18. Terjung, RL, et al; “Physiological and Health Effects of Oral Creatine Supplementation.” Medicine & Science in Sports & Exercise, vol. 32, no. 3, Mar. 2000, pp. 706–717, 10.1097/00005768-200003000-00024; https://www.ncbi.nlm.nih.gov/pubmed/10731017
    19. Guzun, R., et al. “Systems Bioenergetics of Creatine Kinase Networks: Physiological Roles of Creatine and Phosphocreatine in Regulation of Cardiac Cell Function.” Amino Acids, vol. 40, no. 5, 10 Mar. 2011, pp. 1333–1348, 10.1007/s00726-011-0854-x; https://www.ncbi.nlm.nih.gov/pubmed/21390528
    20. Adhihetty, Peter J., and M. Flint Beal. “Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases.” NeuroMolecular Medicine, vol. 10, no. 4, 13 Nov. 2008, pp. 275–290, 10.1007/s12017-008-8053-y; https://www.ncbi.nlm.nih.gov/pubmed/19005780
    21. Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003 Nov;17(4):822-31; https://pubmed.ncbi.nlm.nih.gov/14636102/
    22. Branch, J David. “Effect of Creatine Supplementation on Body Composition and Performance: A Meta-Analysis.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 13, no. 2, 2003, pp. 198–226, 10.1123/ijsnem.13.2.198; https://pubmed.ncbi.nlm.nih.gov/12945830/
    23. Chilibeck, Philip, et al. “Effect of Creatine Supplementation during Resistance Training on Lean Tissue Mass and Muscular Strength in Older Adults: A Meta-Analysis.” Open Access Journal of Sports Medicine, vol. Volume 8, Nov. 2017, pp. 213–226, 10.2147/oajsm.s123529; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679696/
    24. Devries, Michael A, and Stuart M. Philips; “Creatine Supplementation during Resistance Training in Older Adults—a Meta-Analysis.” Medicine & Science in Sports & Exercise, vol. 46, no. 6, June 2014, pp. 1194–1203, 10.1249/mss.0000000000000220; https://pubmed.ncbi.nlm.nih.gov/24576864/
    25. Chilibeck, P. D., et al. “Creatine Monohydrate and Resistance Training Increase Bone Mineral Content and Density in Older Men.” The Journal of Nutrition, Health & Aging, vol. 9, no. 5, 2005, pp. 352–353; https://pubmed.ncbi.nlm.nih.gov/16222402/
    26. Candow, Darren G., et al. “Creatine Supplementation and Aging Musculoskeletal Health.” Endocrine, vol. 45, no. 3, 5 Nov. 2013, pp. 354–361, 10.1007/s12020-013-0070-4; https://pubmed.ncbi.nlm.nih.gov/24190049/
    27. Bogdanis, G C, et al. “Recovery of Power Output and Muscle Metabolites Following 30 S of Maximal Sprint Cycling in Man.” The Journal of Physiology, vol. 482, no. 2, 15 Jan. 1995, pp. 467–480, 10.1113/jphysiol.1995.sp020533; https://www.ncbi.nlm.nih.gov/pubmed/7714837
    28. Mendez-Villanueva, Alberto, et al. “The Recovery of Repeated-Sprint Exercise Is Associated with PCr Resynthesis, While Muscle PH and EMG Amplitude Remain Depressed.” PLoS ONE, vol. 7, no. 12, 17 Dec. 2012, p. e51977, 10.1371/journal.pone.0051977; https://www.ncbi.nlm.nih.gov/pubmed/23284836
    29. Mielgo-Ayuso, Juan, et al. “Effects of Creatine Supplementation on Athletic Performance in Soccer Players: A Systematic Review and Meta-Analysis.” Nutrients, vol. 11, no. 4, 31 Mar. 2019, p. 757, 10.3390/nu11040757; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520963/
    30. Lopez, Rebecca M et al. “Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses.” Journal of athletic training vol. 44,2 (2009): 215-23. doi:10.4085/1062-6050-44.2.215; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657025/
    31. Sakellaris, George, et al. “Prevention of Traumatic Headache, Dizziness and Fatigue with Creatine Administration. A Pilot Study.” Acta Paediatrica, vol. 97, no. 1, 3 Dec. 2007, pp. 31–34, 10.1111/j.1651-2227.2007.00529.x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583396/
    32. Anomasiri, Wilai, et al. “Low Dose Creatine Supplementation Enhances Sprint Phase of 400 Meters Swimming Performance.” Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 87 Suppl 2, 1 Sept. 2004, pp. S228-232; https://pubmed.ncbi.nlm.nih.gov/16083193/
    33. Schneider-Gold, C., et al. “Creatine Monohydrate in DM2/PROMM: A Double-Blind Placebo-Controlled Clinical Study.” Neurology, vol. 60, no. 3, 11 Feb. 2003, pp. 500–502, 10.1212/01.wnl.0000044405.29988.e1; https://pubmed.ncbi.nlm.nih.gov/12578937/
    34. McMorris, T., et al. “Effect of Creatine Supplementation and Sleep Deprivation, with Mild Exercise, on Cognitive and Psychomotor Performance, Mood State, and Plasma Concentrations of Catecholamines and Cortisol.” Psychopharmacology, vol. 185, no. 1, 17 Jan. 2006, pp. 93–103, 10.1007/s00213-005-0269-z; https://pubmed.ncbi.nlm.nih.gov/16416332/
    35. McMorris, T., et al. “Effect of Creatine Supplementation and Sleep Deprivation, with Mild Exercise, on Cognitive and Psychomotor Performance, Mood State, and Plasma Concentrations of Catecholamines and Cortisol.” Psychopharmacology, vol. 185, no. 1, 17 Jan. 2006, pp. 93–103, 10.1007/s00213-005-0269-z; https://pubmed.ncbi.nlm.nih.gov/16416332/
    36. Fuld, J P. “Creatine Supplementation during Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease.” Thorax, vol. 60, no. 7, 1 July 2005, pp. 531–537, 10.1136/thx.2004.030452; https://pubmed.ncbi.nlm.nih.gov/15994258/
    37. Braegger, Christian P., et al. “Effects of Creatine Supplementation in Cystic Fibrosis: Results of a Pilot Study.” Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society, vol. 2, no. 4, 1 Dec. 2003, pp. 177–182; 10.1016/S1569-1993(03)00089-4; https://pubmed.ncbi.nlm.nih.gov/15463870/
    38. Rae, Caroline et al. “Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial.” Proceedings. Biological sciences vol. 270,1529 (2003): 2147-50. doi:10.1098/rspb.2003.2492; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/
    39. Benton, David, and Rachel Donohoe. “The Influence of Creatine Supplementation on the Cognitive Functioning of Vegetarians and Omnivores.” The British Journal of Nutrition, vol. 105, no. 7, 2011, pp. 1100–5, 10.1017/S0007114510004733; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/influence-of-creatine-supplementation-on-the-cognitive-functioning-of-vegetarians-and-omnivores/E2D37729902DDFA6CFC85767AD0421FC
    40. Schilling, Brian K., et al. “Creatine Supplementation and Health Variables: A Retrospective Study.” Medicine & Science in Sports & Exercise, vol. 33, no. 2, 2001, pp. 183–188; https://journals.lww.com/acsm-msse/Fulltext/2001/02000/Creatine_supplementation_and_health_variables__a.2.aspx
    41. Hoffman, Jay, et al. “Effect of Creatine and ß-Alanine Supplementation on Performance and Endocrine Responses in Strength/Power Athletes.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 16, no. 4, Aug. 2006, pp. 430–446, 10.1123/ijsnem.16.4.430; https://pubmed.ncbi.nlm.nih.gov/17136944/
    42. Cook, Christian J, et al. “Skill Execution and Sleep Deprivation: Effects of Acute Caffeine or Creatine Supplementation – a Randomized Placebo-Controlled Trial.” Journal of the International Society of Sports Nutrition, vol. 8, no. 1, 16 Feb. 2011, 10.1186/1550-2783-8-2; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049131/
    43. Volek, Jeff S., et al. “The Effects of Creatine Supplementation on Muscular Performance and Body Composition Responses to Short-Term Resistance Training Overreaching.” European Journal of Applied Physiology, vol. 91, no. 5-6, 1 May 2004, pp. 628–637, 10.1007/s00421-003-1031-z; https://pubmed.ncbi.nlm.nih.gov/14685870/
    44. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    45. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
    46. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[2]:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    47. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    48. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    49. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    50. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    51. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    52. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    53. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
    54. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5; https://pubmed.ncbi.nlm.nih.gov/24760587/
    55. Jason Michael Cholewa, et al; “The Effects of Chronic Betaine Supplementation on Body Composition and Performance in Collegiate Females: a Double-Blind, Randomized, Placebo Controlled Trial”; Journal of the International Society of Sports Nutrition; BioMed Central; 31 July 2018; https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0243-x
    56. Ripps, H. et al. Nov. 2012. “Review: Taurine: A “Very Essential Amino Acid.” Molecular Vision vol. 18. 2673-86. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501277/
    57. Chen, C. et al. Aug. 2019. “Roles of Taurine in Cognitive Function of Physiology, Pathologies, and Toxication.” Life Sciences vol. 15, 231; https://pubmed.ncbi.nlm.nih.gov/31220527/
    58. Waldron, M., et al. May 2018. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine vol. 48,5; 1247-53. https://pubmed.ncbi.nlm.nih.gov/29546641
    59. Guizoni, D. et al. Jan. 2020. “Modulation of Endothelium-Derived Nitric Oxide Production and Activity by Taurine and Taurine-Conjugated Bile Acids.” Nitric Oxide vol. 94,1; 48-53; https://www.sciencedirect.com/science/article/abs/pii/S1089860319302113
    60. Patlar, Suleyman, et al. “The Effect of Glycerol Supplements on Aerobic and Anaerobic Performance of Athletes and Sedentary Subjects.” Journal of Human Kinetics, vol. 34, no. 1, 1 Oct. 2012, pp. 69–79, 10.2478/v10078-012-0065-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/
    61. Nelson, Jeff L, and Robert A Robergs. “Exploring the Potential Ergogenic Effects of Glycerol Hyperhydration.” Sports Medicine, vol. 37, no. 11, 2007, pp. 981–1000, 10.2165/00007256-200737110-00005. https://www.ncbi.nlm.nih.gov/pubmed/17953468
    62. Montner, P., et al. “Pre-Exercise Glycerol Hydration Improves Cycling Endurance Time.” International Journal of Sports Medicine, vol. 17, no. 1, 1 Jan. 1996, pp. 27–33, 10.1055/s-2007-972804. https://pubmed.ncbi.nlm.nih.gov/8775573/
    63. Patlar, Suleyman, et al. “The Effect of Glycerol Supplements on Aerobic and Anaerobic Performance of Athletes and Sedentary Subjects.” Journal of Human Kinetics, vol. 34, no. 1, 1 Oct. 2012, pp. 69–79, 10.2478/v10078-012-0065-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/
    64. Anderson, M. J., et al. “Effect of Glycerol-Induced Hyperhydration on Thermoregulation and Metabolism during Exercise in the Heat.” International Journal of Sport Nutrition, vol. 11, no. 3, 29 Sept. 2001, pp. 315–333. https://research.monash.edu/en/publications/effect-of-glycerol-induced-hyperhydration-on-thermoregulation-and
    65. Pietz J, Landwehr R, Kutscha A, Schmidt H, de Sonneville L, Trefz FK. Effect of high-dose tyrosine supplementation on brain function in adults with phenylketonuria. J Pediatr. 1995;127(6):936-943; https://pubmed.ncbi.nlm.nih.gov/8523192
    66. Attipoe, Selasi, et al. “Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature.” Military Medicine, vol. 180, no. 7, July 2015, pp. 754–765, 10.7205/milmed-d-14-00594; https://academic.oup.com/milmed/article/180/7/754/4160625
    67. Pomeroy, Diane E., et al. “A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel.” Nutrients, vol. 12, no. 2, 20 Feb. 2020, p. 545, 10.3390/nu12020545; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071459/
    68. Legaz, M. et al. Feb. 1983. “Endogenous Inactivators of Arginase, L-Arginine Decarboxylase, and Agmatine Amidinohydrolase in Evernia prunastri Thallus.” Plant Physiology vol. 71,1; 300-2. https://pubmed.ncbi.nlm.nih.gov/16662821
    69. Morrissey J. et al. Jan. 1997. “Agmatine Activation of Nitric Oxide Synthase in Endothelial Cells.” Proceedings of the Association of American Physicians vol. 109,1;51-7. https://pubmed.ncbi.nlm.nih.gov/9010916/
    70. Ismail, I., et al. 2007. “Rehydration with Sodium-Enriched Coconut Water After Exercise-Induced Dehydration.” The Southeast Asian Journal of Tropical Medicine and Public Health vol. 38,4 (2007): 769-85. https://pubmed.ncbi.nlm.nih.gov/17883020/
    71. M. Saat, et al. 2002 “Rehydration After Exercise with Fresh Coconut Water, Carbohydrate-Electrolyte Beverage and Plain Water.”Journal of Physiological Anthropology and Applied Human Science 21 no. 2 (2002). https://pubmed.ncbi.nlm.nih.gov/12056182
    72. Wallace JMW, McCormack JM, McNulty H, et al. Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. Br J Nutr. 2012;108(7):1264-1271. doi:10.1017/S000711451100674X. https://pubmed.ncbi.nlm.nih.gov/22172554
    73. Cohen BM, Renshaw PF, Stoll AL, Wurtman RJ, Yurgelun-Todd D, Babb SM. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. JAMA. 1995;274(11):902-907; https://pubmed.ncbi.nlm.nih.gov/7674505
    74. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010); https://link.springer.com/article/10.1186/1550-2783-7-5
    75. Norager, C. B., et al. “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.” Clinical Endocrinology, vol. 65, no. 2, Aug. 2006, pp. 223–228, 10.1111/j.1365-2265.2006.02579.x; https://pubmed.ncbi.nlm.nih.gov/16886964/
    76. Astrup, A, et al. “Caffeine: A Double-Blind, Placebo-Controlled Study of Its Thermogenic, Metabolic, and Cardiovascular Effects in Healthy Volunteers.” The American Journal of Clinical Nutrition, vol. 51, no. 5, 1 May 1990, pp. 759–767, 10.1093/ajcn/51.5.759; https://academic.oup.com/ajcn/article/51/5/759/4695347
    77. Keijzers, Gerben B., et al. “Caffeine Can Decrease Insulin Sensitivity in Humans.” Diabetes Care, vol. 25, no. 2, 1 Feb. 2002, pp. 364–369; https://care.diabetesjournals.org/content/25/2/364.long
    78. Everett, J.M., Gunathilake, D., et al. Journal of Nutrition & Intermediary Metabolism; “Theanine Consumption, Stress and Anxiety in Human Clinical Trials: A Systematic Review.” 2016; https://www.sciencedirect.com/science/article/pii/S2352385915003138
    79. Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional neuroscience, 11(4), 193-198; https://www.ncbi.nlm.nih.gov/pubmed/18681988
    80. Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional neuroscience, 13(6), 283-290; https://www.ncbi.nlm.nih.gov/pubmed/21040626
    81. Kelly, S. P., Gomez-Ramirez, M., Montesi, J. L., & Foxe, J. J. L-Theanine and Caffeine in Combination Affect Human Cognition as Evidenced by Oscillatory alpha-Band Activity and Attention Task Performance. The Journal of Nutrition, 138(8); https://academic.oup.com/jn/article/138/8/1572S/4750819
    82. Stohs, Sidney J., et al. “A Review of the Human Clinical Studies Involving Citrus Aurantium (Bitter Orange) Extract and Its Primary Protoalkaloid P-Synephrine.” International Journal of Medical Sciences, vol. 9, no. 7, 2012, pp. 527–538, 10.7150/ijms.4446. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444973/
    83. Schena, Giorgia, and Michael J. Caplan. “Everything You Always Wanted to Know about β3-AR * (* but Were Afraid to Ask).” Cells, vol. 8, no. 4, 16 Apr. 2019, p. 357, 10.3390/cells8040357. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523418/
    84. Gutiérrez-Hellín, Jorge, and Juan Del Coso. “Acute P-Synephrine Ingestion Increases Fat Oxidation Rate during Exercise.” British Journal of Clinical Pharmacology, vol. 82, no. 2, 7 May 2016, pp. 362–368, 10.1111/bcp.12952. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972152/
    85. Ratamess, Nicholas A., et al. “The Effects of Supplementation with P-Synephrine Alone and in Combination with Caffeine on Resistance Exercise Performance.” Journal of the International Society of Sports Nutrition, vol. 12, no. 1, 17 Sept. 2015, 10.1186/s12970-015-0096-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573476
    86. Nelson, B, et al; “Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium)”;J Agric Food Chem; 55(24):9769-75; 2007; https://www.ncbi.nlm.nih.gov/pubmed/17966980
    87. NuLiv Science; AstraGin Product Dossier; https://docdro.id/rA01t9O
    88. Damar, U., Gersner, R., et al. Expert Review of Neurotherapeutics; “Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research.” 2016; https://pubmed.ncbi.nlm.nih.gov/27086593/
    89. Strumia, E., Pelliccia, F., et al. Advances in Therapy; “Creatine phosphate: pharmacological and clinical perspectives.” 2012; https://pubmed.ncbi.nlm.nih.gov/22297802
    90. Ma, Tuo, et al. “Huperzine a Promotes Hippocampal Neurogenesis in Vitro and in Vivo.” Brain Research, vol. 1506, 19 Apr. 2013, pp. 35–43, 10.1016/j.brainres.2013.02.026; https://pubmed.ncbi.nlm.nih.gov/23454433/

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