Soul Performance Nutrition Aura Endorphin Flow: Optimized Nitric Oxide AND Hydration

Soul Performance Nutrition is the brainchild of Matthew Karich, a regular contributor to the PricePlow Discord and a guest on Episode #068 of the PricePlow Podcast.

We regard Soul Performance as having one of the most methodical formulation philosophies in the industry. Regular readers of the blog will know why, since we’ve covered their Velositol-enhanced collagen supplement, Bliss Revitalize Collagen.

Soul Performance Nutrition Aura Endorphin Flow Pre-Workout

Soul Performance Nutrition Aura Endorphin Flow is a pre-workout that flows, thanks to plenty of electrolytes/osmolytes and nitric oxide boosting Nitrosigine that also supports cognition!

Soul did things differently, initially launching five supplements before coming out with their pre-workout. But it was well worth the wait, because this one’s built different:

Introducing Aura Endorphin Flow from Soul Performance Nutrition

Today we’ll be talking about Soul’s new pre-workout, Aura Endorphin Flow.

As its name suggests, this formula has some excellent nootropic support, which can help you focus and get motivated before your toughest workouts. Even the primary pump ingredient — Nutrition21’s Nitrosigine — exerts nootropic effects!

To key in on a few important doses so you know where we’re headed, Aura has 250 milligrams of caffeine, a clinically-verified 1500 milligrams of Nitrosigine, and 39% sodium next to 11% potassium! The latter is what’s extra unique here — Soul’s use of electrolytes to increase both hydration and vasodilation:

Electrolytes With Osmolytes: A Powerful Solute-Driven Pump And Buzz

One topic we frequently write about with modern pre-workout supplements is the use of osmolytes. Veteran supplement consumers will probably notice Aura Endorphin Flow goes heavy on electrolyte support – particularly sodium.

We almost never see pre-workouts using such large doses of sodium, magnesium, and potassium. So the natural question is: Why did Soul Performance Nutrition make this design choice for Aura Endorphin Flow?

We get into it below, but first, check PricePlow’s coupon-powered deals and sign up for our pre-workout news alerts so that you don’t miss a beat:

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Chasing vasodilation with Nitrosigine and added minerals

Aura Endorphin Flow utilizes two primary ways to increase vasodilation:

Aura Endorphin Flow

  1. With Nitrosigine (inositol-stabilized arginine silicate) to increase nitric oxide production
  2. With mineral electrolytes (specifically potassium) to activate potassium channels in the smooth muscle cells that line blood vessel walls

Regarding the first point, Nitrosigine promotes an increase in NO levels in the body, thus promoting vasodilation. This is a phenomenon where your arteries dilate, which allows blood to flow through them more easily.[1] This leads to better circulation, improved delivery of oxygen and nutrients, as well as increased removal of cellular-metabolic waste products like lactic acid.[2]

Ultimately, when training, we want vasodilation – specifically to feed and support activities in our muscles, and Soul Performance Nutrition provides multiple mechanisms to get it. But there’s also osmolytes added as well:

Why add osmolytes to a pre-workout?

To understand why this formula is so unique and awesome, we need to spend a bit of time diving into the subject of what osmolytes are, and how osmosis works.


Osmolytes are special solutes preferred by your cells for the purpose of maintaining water volume. When cells take up solutes, water naturally migrates into those cells. Image courtesy of Wikimedia.

An osmolyte is a solute used by cells to maintain water volume.[3] This is a process driven by osmosis: Water migrates from an area of low water potential (low dissolved solute content) to an area of high water potential (high dissolved solute content).

Table of Contents

This process happens because the water “wants” to seek an equilibrium on both sides of a semi-permeable membrane (i.e., a membrane that lets water, but not solutes, pass through). Water will move until water pressure is equal on both sides of the membrane.

So when your cells are full of osmolytes, they naturally draw more water.

Your cells’ process for maintaining water balance is not an afterthought. It’s crucial for maintaining the health and longevity of your cells and, indeed, your entire body. In fact, it’s so important that your cell membranes actually have transporters specialized for moving solutes across the membrane – osmolyte transporters.[4]

Synergistic Effects For A MEGA-PUMP

So, we can increase intracellular volume by supplementing with osmolytes like taurine and betaine, which we’ll discuss in this article.

But looking at our illustration of osmosis, it’s clear that the total amount of water available matters – i.e., the less water there is inside your body, but outside your cells (extracellular fluid volume), means less water is available for supplemental osmolytes to move into your cells.

That’s where Matthew Karich got the idea to combine osmolytes with big doses of electrolytes – sodium in particular.

For example, sodium increases extracellular fluid volume – fluid retention is a well-known effect of high sodium intake – so taking a large dose of sodium with osmolytes significantly increases the amount of water your cells have the potential to absorb.

This should, in theory, lead to a massive pump, especially when synergized by the nitric oxide enhancing effects of Nitrosigine. Additionally, there may be increased effectiveness of other water soluble ingredients like caffeine, through direct exposure to your body’s cells.[5]

Additionally, there are some mechanistic ways that potassium supports vasodilation, covered in the potassium section below.

We think Soul Performance Nutrition has a tiger by the tail with this concept. Anecdotally, consumer feedback from this formula has been pretty impressive, too. So with that stated, let’s get into the label:

Soul Performance Nutrition Aura Endorphin Flow Ingredients

In a single 1-level-scoop (21.3 g) serving of Aura Endorphin Flow from Soul Performance Nutrition, you get the following:

  • Betaine Anhydrous (Trimethylglycine) – 2,500 mg

    Betaine or trimethylglycine (TMG) is an ergogenic aid, meaning it helps increase your capacity for physical work – power output, reps, and aerobic capacity are aspects of athletic performance commonly improved by ergogenic aids.

    Methyl donor

    Soul Performance Nutrition Aura Endorphin Flow Ingredients

    Probably the most important thing you should know about betaine is it helps increase adenosine triphosphate (ATP) production.[6]

    Betaine does this by acting as a methyl donor,[7] which means the betaine molecule transports methyl groups to sites where they’re needed for a variety of metabolic processes. As far as methyl donors go, betine is one of the most effective methyl donors known to supplement science.[8]

    Methylation is important for keeping homocysteine blood levels in the appropriate range,[9] which is important since homocysteine is a known risk factor for cardiovascular disease (CVD), heart attacks, and strokes.[10]

    In other words, betaine’s value proposition goes beyond your next workout – it’s a good ingredient for maintaining long-term cardiovascular health and athletic performance.

    Osmolyte and cellular hydration

    Betaine is also an osmolyte, and can increase osmotic pressure around your body’s cells. Since osmosis naturally causes water to move from areas of high osmotic pressure to areas of low osmotic pressure, this forces more water into your cells, which leads to a state called cellular hyperhydration.

    Extra water brings extra nutrients and fuel, which can fortify your cells against metabolic stress[11,12] and heat shock.[13,14]

    Betaine research

    Betaine Muscle

    A landmark 2013 study showed that 2.5 grams of betaine every day can have profound effects on body mass and strength[12]

    These two key mechanisms are largely why betaine can improve:

    • Strength[15,16]
    • Power[15-17]
    • Body composition[12,18]

    An especially notable study, published in 2013, showed that daily supplementation with 2,500 milligrams of betaine – the same dose used in Aura Endorphin Flow – can cause over 5 pounds of muscle gain and 6 pounds of fat loss in a 6-week period. That translates to a 3% decrease in body fat.[12,18]

    Another study from 2018 found similar results. In this study, collegiate women taking betaine during a resistance-training regimen lost 4 pounds more body fat than the control group.[19]

  • L-Ornithine Alpha-Ketoglutarate – 2,000 mg

    Known as OKG, L-Ornithine Alpha-Ketoglutarate (OKG) is combined from two molecules, ornithine and alpha-ketoglutarate.

    Ornithine is an amino acid that binds to ammonia, a toxic metabolic waste product that builds up during exercise. Since ammonia causes muscular fatigue and can tank athletic performance as it accumulates,[20] removing it more efficiently through supplements like ornithine can increase athletic endurance.[20,21] Alpha-ketoglutarate is an intermediate in the Krebs cycle, the process that produces energy in our cells.

    First, let’s look at some benefits of ornithine supplementation:

    Ornithine Increases HGH

    Ornithine can upregulate human growth hormone (HGH, or simply GH),[22] an anabolic hormone involved in stimulating the growth and reproduction of many types of cells. GH is super useful for building muscle, burning fat, and improving athletic recovery and performance.

    Ornithine has been shown to significantly increase GH plasma levels in male weightlifters.[23]

    Ornithine Improves sleep quality

    When it comes to recovering from exercise and building muscle, nothing is more important than excellent sleep, and it seems ornithine can help us here, too. One study found that ornithine supplementation can significantly decrease stress markers and improve sleep quality – it’s particularly good for DHEA-to-cortisol ratios.[24]

    The ketoglutarate side of the molecule

    Why start with betaine and OKG In an email, Matt Karich of Soul Performance Nutrition noted the following:

    The high level of electrolytes were paired with osmolytes like betaine, taurine, and glycine coming from the chelated minerals. Combined with Nitrosigine this was my approach to “performance and pump”. Instead of going down the mega dose citrulline route I pulled

    in ornithine alpha ketoglutarate.

    OKG has some interesting up and downstream conversion effects in the body. Consuming ornithine alongside alpha-ketoglutarate is able to suppress the conversion of ornithine into alpha-ketoglutarate and indirectly promote conversion of ornithine into other metabolites such as arginine. Alpha-ketoglutarate can also be an intermediate in glutamine metabolism that can buffer ammonia independently of the urea cycle via using ammonia to reform glutamine, reinforcing the performance aspect of the formula.

    — Matt Karich, Soul Performance Nutrition

    Looking at some research, it’s been shown that consuming OKG actually leads to arginine production, while ornithine hydrochloride and AKG did not![25] We’ll get deeper into arginine shortly with Nitrosigine.

  • Taurine – 2,000 mg

    Taurine is an ingredient that we’re increasingly seeing in all kinds of supplements, and that’s because it simply works in pretty much any kind of formula. Whether you’re looking for ergogenic effects, improved hydration, better mitochondrial efficiency, dopamine upregulation, body fat browning, or improved antioxidant status, taurine is a great supplement to consider.

    Taurine’s osmolytic effects

    Soul Performance Nutrition Aura Endorphin Flow

    Like betaine, which we discussed above, taurine is an osmolyte[26] capable of inducing cellular hyperhydration by the same mechanism.

    Whether induced by betaine or taurine, cellular hyperhydration comes with the same benefits: increased cellular-metabolic efficiency and improved resilience to heat stress.[27]

    When taken immediately before exercise, a single 1,000-milligram dose of taurine, only half the dose used in Aura Endorphin Flow, can significantly improve athletic endurance.[28]

    Taurine is also a powerful antioxidant[29,30] and can help support calcium signaling in muscle tissue.[31] This optimizes athletic performance and prevents cramping.

    The brain benefits of taurine

    Taurine imitates a neurotransmitter called gamma-aminobutyric acid (GABA), which has calming and anti-inflammatory effects on neurons[32] by downregulating calcium signaling in the brain. It can also increase mitochondrial biogenesis in your brain, which is beneficial since mitochondria produce all the energy for your cells, including brain cells.[32,33]

    Taurine can also upregulate dopamine production and signaling,[34] which can go a long way toward keeping you focused and motivated during your workout.

    Taurine promotes the browning of body fat and increases caloric expenditure

    The reason most of us work out is to lose fat and build muscle – and, as it turns out, taurine can help with that too.

    Taurine can increase your body’s proportion of brown adipose tissue (BAT), a type of fat tissue that contains lots of mitochondria.[35] In fact, BAT gets its name because it’s so packed with mitochondria, it appears dark brown under a microscope!

    Taurine Browning of Fat

    Taurine can induce the browning of fat,[36] which is important because brown fat is more mitochondrial-dense and metabolically active!

    The extra mitochondria in BAT work around the clock to generate tons of cellular energy, burning calories as heat through a process called non-shivering thermogenesis (NST). In fact, taurine actually converts white adipose tissue (WAT), which is comparatively devoid of mitochondria and doesn’t drive NST,[37] into BAT. This can be good for body composition for obvious reasons: the more BAT you have, the more calories you’ll burn daily through NST.

    Taurine can also selectively inhibit the growth of new WAT cells[38] while promoting the formation of new BAT.

    Because the mitochondria in BAT burn glucose and fatty acids, having more BAT can improve blood lipids and blood glucose, thus mitigating some of the harmful effects associated with excess body fat.[39]

    Since taurine is conditionally essential, meaning your metabolic requirements go up as you work out harder, intense gym goers can probably stand to benefit from taurine supplementation.[28,32,40]

    The dose!

    We’re stoked to see a 2,000 milligram dose here. The effects of taurine are dose-dependent,[41] so more than the industry standard 1,000 milligrams is definitely better.

  • L-Tyrosine – 2,000 mg

    Tyrosine is a great pre-workout addition for three reasons:

    Dopamine and adrenaline upregulation

    Soul Performance Aura Endorphin Flow

    Here comes the flow…

    As a catecholamine precursor, tyrosine can help increase your body’s production of key neurotransmitters like dopamine, adrenaline, and noradrenaline.[42-44] More of these neurotransmitters can translate into better focus, motivation, and energy – and even faster fat burning.[45]


    Finally, tyrosine can help promote alertness. Specifically, it’s great for mitigating the effects of sleep deprivation. Research conducted by the U.S. military has found that tyrosine is even better at this than caffeine,[36,46] which is obviously saying a lot.

    Thyroid support

    Tyrosine can also help improve thyroid function, because it’s also a precursor to thyroid hormones, including triiodothyronine (T3) and thyroxine (T4).

    Since your thyroid is basically the master gland of your whole metabolism, problems with your thyroid can spell disaster for your health and performance. And unfortunately, both dieting and strenuous exercise can downregulate thyroid function by quite a bit in isolation – together, the risk of thyroid issues is even higher.[47-49]

    The 2000 milligram dose is also solid – long ago, we were stuck at 500-1000 milligrams. Nowadays, aggressive young brands like Soul Performance Nutrition go a bit bigger.

  • Inositol-stabilized Arginine Silicate (as Nitrosigine) – 1,500 mg

    Nitrosigine PricePlow

    Yes! We have a full 1.5g dose of Nitrosigine for long-lasting pumps, endurance, and even some cognitive-supporting effects!

    Nitrosigine is one of the most sophisticated and efficacious nitric oxide (NO) boosting supplements on the market today. It consists of arginine combined with inositol and silica,[39] and is known as inositol-stabilized arginine silicate or ASI in many research papers.

    To start, an in-vitro study showed that Nitrosigine has more NO-boosting power than common nitric oxide boosting ingredients like L-arginine, L-arginine AKG, L-citrulline, L-citrulline malate, and agmatine sulfate.[50] With help from the additional components in Nitrosigine, the arginine stays intact as it passes through the stomach and into the intestines, where it gets absorbed into your bloodstream.

    As a result, Nitrosigine acts fast and lasts long. It’s been shown to increase blood arginine levels as soon as 30 minutes after consumption,[51] with arginine remaining in plasma lasting up to six hours.[52]

    Short history of Nitrosigine: from arginine to citrulline to inositol-stabilized arginine silicate

    Nitrosigine Arginine Inositol Silicate

    Not only does Nitrosigine boost N.O. levels acutely after consumption, it can keep them elevated for a long period of time, too!

    Generic arginine actually used to be the supplement industry’s go-to NO booster, since arginine is the chemical precursor to nitric oxide. It can provide benefits in large doses,[53,54] but such large doses can also lead to GI distress.[55] So over time, it fell into disfavor because of its poor oral bioavailability that led to uncomfortably-high dosing.[56-58]

    That’s the problem Nitrosigine was developed to solve: Nutrition21 basically set out to build a better arginine — with better effects at smaller doses — and they knocked it out of the park. Not only has Nitrosigine beat generic arginine, it’s now gradually replacing citrulline,[59] an arginine precursor amino acid[30] that served as generic arginine’s replacement in the interim.

    The issue with citrulline is you need big doses for the desired effect[31,34] while Nitrosigine is much more economical, and can achieve very similar (if not slightly better) results at much smaller doses![59]

    Nitrosigine studies

    To give you an idea of what we mean about citrulline vs. Nitrosigine, let’s start by pointing out that one study found a 1,500 milligram dose of Nitrosigine – the same dose used in Aura Endorphin Flow – can increase arterial blood flow as measured by flow-mediated dilation by an impressive 31%. It took 8 grams of citrulline malate to get roughly the same effect![59]

    Nitrosigine 2022 Cognitive Study Infographic

    A nitric oxide booster that improves cognition?! Yes – Nutrition21 passed around this helpful infographic after the Nitrosigine cognition study on healthy young adults was published.[38]

    Although boosting NO is typically discussed in the context of athletic performance, it can have nootropic benefits as well. This makes good sense – your brain needs blood, nutrients, and waste removal no less than the rest of your body. In fact, your brain actually needs it more.

    Even compared to other NO boosters, Nitrosigine appears to be especially good at improving cognitive performance.

    For example, exhaustive exercise usually causes a temporary and slight, but noticeable, decline in cognitive performance. And, according to one study, Nitrosigine can prevent this decline from taking place.[37,60] In fact, cognitive effects may begin as quickly as 15 minutes after ingestion.[37]

    Other studies have found that Nitrosigine can still improve cognition, even when subjects haven’t recently exercised. One study in healthy young men found that Nitrosigine can improve multitasking,[35] and another found it can improve performance on a memory test.[38]

    Lighter and enabling unique flavor profiles

    Finally, we’re also finding that supplements utilizing Nitrosigine are lighter (both to ship but also on the gut) and offer more unique flavor options. Avoiding citrulline allows brands to avoid the flavor systems that citrulline pigeonholes them into. And if you know one thing about Soul Performance Nutrition, it’s that they have some very unique and natural flavorings.

    If you’re interested in a more in-depth analysis of this innovative ingredient, check out PricePlow’s article, Nitrosigine: The Nitric Oxide Booster That Enhances Brain Function.

  • Yerba santa (Eriodictyon Californicum) [Aerial Parts] Extract (as SantEnergy Nu) – 400 mg

    SantEnergy is a trademarked yerba santa extract. This is a shrub native to California, Oregon, and northern Mexico that has been used for thousands of years by indigenous peoples of these regions to facilitate deep breathing and help reduce symptoms of respiratory inflammation.[61]

    Scientific research has borne out their traditional wisdom, and has found it can help relieve bronchial congestion, asthma, and hayfever.[62] Most people who take yerba santa can feel their breathing get significantly easier, thus making challenging workouts easier to deal with.

    Yerba santa can possibly help body composition, too, as it increases calorie burn[63] by upregulating thermogenesis.[64]

  • Alpha-GPC (L-Alpha-Glycerylphosphorylcholine 50%) – 300 mg

    The first of two choline-based ingredients, Alpha-GPC is an especially bioavailable form of the B vitamin that the body uses to build and maintain the phospholipid bilayer membranes that enclose the contents of all your cells.[65] It’s also needed for your cells to communicate with each other.[66]

    Nitrosigine Benefits

    One last Nitrosigine image — inositol-stabilized arginie silicate is research-backed and “gym backed” — Image courtesy Nutrition21

    Choline is a precursor to acetylcholine, a neurotransmitter that’s crucial for learning and memory.[67] We often refer to acetylcholine as “the learning neurotransmitter” because of how important it is for cognition. Choline supplements can increase acetylcholine production, leading, in turn, to boosts in cognitive function.[68,69]

    Choline is also an important methyl donor, just like betaine, and can similarly help keep homocysteine under control.[70]

    Alpha-GPC is our preferred form of choline, thanks to the fact it easily crosses the blood-brain barrier[71] and is more bioavailable than generic choline.

  • Citicoline Sodium (Cytidine 5′-Diphosphocholine) – 250 mg

    Citicoline is another form of choline, good for improving some specific dimensions of cognitive performance, including focus, attention, and mental energy.[72,73]

    It consists of choline and uridine, which synergistically improves circulation in the brain and upregulates neuronal mitochondrial function.[74,75]

    It also upregulates dopamine, which is why we call this the feel-good form of choline.[76]

  • Natural Caffeine (from Coffee (Coffee arabica) Bean) – 250 mg

    Caffeine is a methylxanthine stimulant capable of crossing the blood-brain barrier. Its high bioavailability in the central nervous system makes it a powerful tool for improving mood, focus, energy, and even athletic performance.[77]

    Caffeine helps us stay awake and alert by antagonizing adenosine, a nucleotide that accumulates in your brain during your waking state, thus producing mental fatigue.[78] That means a hefty dose of caffeine can help you get through your toughest workouts, even when you didn’t get quite enough sleep the night before.

    What’s less well-known is that caffeine increases cellular metabolism as well. It does this by inhibiting phosphodiesterase, an enzyme responsible for breaking down cyclic adenosine monophosphate (cAMP). This naturally raises cAMP levels, and since cAMP tells your cells to burn calories for energy, this revs up your whole-body metabolism.[79-81]

    Caffeine is especially good at burning fat. Animal studies on caffeine have found it can increase fat burning by an impressive 50%.[82]

    Thanks mostly to its effects on cellular metabolism, caffeine can improve several aspects of athletic performance, including strength, speed, and endurance.[83] It’s one of the cheapest no-brainer ergogenic aids there is. It can also improve attentiveness, alertness, reaction time, and working memory,[84-86] as many of us can attest.

    250 milligrams is a perfect dose for Soul Performance Nutrition – not overwhelming, but not weak.

    Matt Karich chimes in on the energy blend:

    Here’s what Matt had to say about this energy blend:

    Onto the energy side I had a very specific strategy I am curious for your feedback on. I spoke very early on with NNB about paraxanthine before MuscleTech licensed it. So my intention was to recreate the sensation with standard caffeine because I couldn’t access it. This is where Natural caffeine, Senactiv, Alpha-GPC, citicoline, SantEnergy, and tyrosine were brought together. This again plays off of the electrolytes and osmolytes and provides in my opinion a very linear and cognitive increase in energy that doesn’t have the same attributes

    anecdotally as a standard caffeine source. Think I came close?

    — Matt Karich, Soul Performance Nutrition

    Absolutely, Matt!

  • Senactiv (from Panax notoginseng [Root] and Rosa roxburghii [Fruit]) Extracts – 50 mg

    Soul Performance Aura Endrophin Flow Reviews

    The reviews — most of which came from the PricePlow Discord — are in, and they’re spectacular!

    Senactiv is a patented[87] extract of ginseng and chestnut rose developed by NuLiv Science.

    It’s a senolytic agent, meaning it can selectively induce apoptosis of senescent cells.[88-93] This comes with a number of benefits for health and performance, because senescent cells are metabolic dead weight, wasting metabolic resources, at best, and obstructing the proper function of organs and tissues, at worst.

    In one randomized, double-blind, placebo-controlled study, the ginseng-derived bioactive constituent of Senactiv was shown to prevent excessive muscle damage and inflammation in response to exercise, as well as speeding up glycogen replenishment.[94]

    It also had a beneficial effect on endurance: time to exhaustion during a cycling test increased by 20%.[94]

  • AstraGin (from Astragalus membranaceus [Root] and Panax notoginseng [Root]) Extracts – 50 mg

    AstraGin is another patented extract from NuLiv Science.

    Soul Performance Bliss Collagen

    Soul Performance is out with a new beauty and wellness collagen product named Bliss Revitalize Collagen backed with Velositol.

    This one combines bioactive constituents from astragalus and ginseng to improve nutrient bioavailability. It works by upregulating certain transporter proteins in the small intestine, leading to improved uptake of nutrients like amino acids, creatine, and omega-3 fatty acids.

    Other research indicates that one component in AstraGin can reduce gut inflammation and strengthen intestinal tissue.[95]

  • Magnesium (from Magnesium Bisglycinate chelate (TRAACS)) – 80 mg (19% DV)

    It’s great to see a sizable dose of the electrolyte mineral magnesium in Aura Endorphin Flow, and it brings us into the core concept of the formula: synergistic effects between electrolytes and osmolytes.

    Magnesium is an especially important electrolyte to include because, unfortunately, the magnesium content of American food has been gradually declining for at least a century.

    Peer-reviewed research shows that supplementation to correct even a mild magnesium deficiency can improve:

    • Blood pressure[96-99]
    • HbA1c and blood glucose[96,100,101]
    • Insulin production[96,100,102]
    • Insulin sensitivity[96,100,101,103]
    • Type 2 diabetes risk[104-106]
    • Bone mineral density[107]
    • PMS symptoms[108-111]
    • Lactic acid disposal[112]
    • Muscle gains[113]
    • C-reactive protein level and effects[113,114]
    • Systemic inflammation[113-115]
    • Exercise-induced muscle damage[116]
    • Migraine symptoms and frequency[117-119]
  • Sodium (from Sodium Chloride, Sodium Citrate, and Di-Sodium Phosphate) – 900 mg (39% DV)

    Now we get to the mack daddy of Aura Endorphin Flow: the massive sodium dose.

    This may be the most sodium we’ve ever seen in a pre-workout. We’ve seen 1-gram doses of salt before, but salt is only half sodium! Here we nearly have an entire gram of pure sodium.

    First, let’s get back to our quote from Matt Karich, where he talks about some of the effects from his single-blinded beta-tests:

    The high levels of sodium in the formula are intended to expand blood volume by retaining fluids in the circulatory system and preventing a drop in blood pressure. By leveraging this I could take advantage of some of the huge increases in performance that sodium can yield when used properly and in my opinion change the perception of how stimulants feel.

    This was tested in the PricePlow Discord through a beta test. Testers had two samples, same exact ingredients in both formulas. The first sample had very low electrolytes, including 50mg yield of sodium. The second is the formula as released, 900mg sodium yield with supporting ingredients. Universally all testers said the formula was more intense and aggressive despite all the other ingredients besides electrolytes remaining the same. This plays off of the vasodilatation ingredients mentioned earlier.

    — Matt Karich, Soul Performance Nutrition

    Now that you have Matt’s angle, let’s dig into the background information and find some research.

    Given the negative press about sodium, it’s understandable that you may regard this dose with apprehension. But as we’ll demonstrate, there’s not necessarily any cause for concern. In fact, high-dose sodium can be a boon for health under certain circumstances.

    That being said, the following discussion is not medical advice. Before modifying your sodium intake, you should talk to your doctor. It’s still possible to get too much sodium, depending on your age, health, and other sources of sodium intake.

    Why so much sodium?

    Soul Performance Nutrition Aura Endorphin Flow BSCG Certification

    Yes, like Soul’s other products, Aura Endorphin Flow is BSCG-Certified, meaning it’s tested to be free of banned substances!

    The first reason is that sodium is the main electrolyte mineral lost in sweat. You can expect to lose approximately 0.9 grams of sodium per liter of sweat, with the next biggest loss being potassium at only 0.2 grams per liter.[120]

    Put another way, we lose four times as much sodium in sweat as we do potassium,[120] and we lose even less of the other electrolytes. So if you’re going to break a sweat, sodium in your pre-workout is probably a good idea.

    Sodium depletion can impair performance and recovery as the mineral is needed for muscle contractions.[121] Muscles that are sodium-deprived won’t function at their peak.[122] In extreme cases, sodium deficiency can be life-threatening.[123] This may not be a concern for indoor workouts, but if you’re outside in the heat, it can become a big deal faster than you think.

    What constitutes sodium excess?

    Now that we’ve talked a bit about what happens if your sodium intake is low, let’s talk about what happens when you get too much and, more to the point, how much sodium is too much.

    The long-standing official sodium intake recommendation is for Americans to consume 2,300 milligrams or less, per day. However, recent research has raised important questions, and even suggests we may need more sodium than this for optimal health.

    Ironically, the negative consequences of insufficient sodium intake closely resemble those of excessive sodium intake. As Thomas Remer points out in his article, “High salt intake: Detrimental not only for blood pressure, but also for bone health”:

    “[C]urrent evidence from prospective cohort studies suggests a J-shaped association between sodium intake and cardiovascular events, based on studies from >300 000 people, and suggests that the lowest risk of cardiovascular events and death occurs in populations consuming an average sodium intake range (3-5 g/d). The increased risk of cardiovascular events associated with higher sodium intake (>5 g/d) is most prominent in those with hypertension.”[9]

    The data cited in this article shows that, statistically, adverse health outcomes from sodium consumption do not appear until sodium intake exceeds 5,000 milligrams per day. The keyword is statistically, as individual cases vary.

    Can you get too little sodium?

    The same data shows that similar adverse effects appear when sodium intake is less than 3,000 milligrams per day. Note that the 2,300-milligram recommendation is below this threshold.

    For example, a 2011 study published by the Journal of American Medicine, which included over 28,000 participants, found urinary sodium intakes under 3,000 milligrams a day increased subjects’ average risk of being hospitalized for congestive heart failure.[124] The same study found no increased risk of cardiovascular disease from intakes up to 7,000 milligrams of sodium per day.[125]

    Soul Performance Nutrition Matt Karich

    Meet Matt Karich, an engineer who’s putting his talents to use in the dietary supplement industry, with refreshingly unique, third-party tested formulas. We discuss this and more in PricePlow Podcast #068.

    Another study from the same year, a meta-analysis, looked at data from seven different studies and found that sodium restriction actually increased overall mortality in heart disease patients.[126]

    Again, individual circumstances vary! Studies going all the way back to 1987 have found that for any given patient, eating more sodium is about as likely to decrease blood pressure as it was to increase it. Interestingly, most participants saw no change in blood pressure at all.[127] Other research has found that patients who get randomized to a low-sodium diet have a 25% lower risk of heart attack or stroke.[128]

    You may or may not be able to tolerate sodium intakes this high, and if you’re not sure, talk to your doctor.

    But, all of this is to say a 900-milligram dose of sodium is likely quite a positive thing for your training!

    The Aura Endorphin Flow sodium angle – fluid retention for massive pumps!

    What we’ve discussed so far is well and good, but it’s not the main reason that we have such a big dose of sodium in Aura Endorphin Flow. The main reason is that sodium upregulates an anti-diuretic hormone called vasopressin. It promotes fluid retention across the body by decreasing the amount of water that kidneys eliminate during their normal filtration process.[129]

    Soul Performance Nutrition Sodium

    Ultimately, a higher sodium intake leads to increased extracellular fluid volume[130] And, again, this means that the osmotic equilibrium across your cells’ membranes will permit a higher volume of water inside your cells!

    Pumps are also driven by blood and, as it turns out, sodium increases blood volume as well.[131]

    So you can see why we might think of sodium as the ultimate pump ingredient – we’re glad to see Soul Performance trying this angle. It’s an exciting development in pre-workout formulation.

  • Potassium (from Potassium Glycinate Complex and Potassium Chloride) – 500 mg (11% DV)

    Soul Performance wasn’t content to rest on their laurels with the big sodium dose, though – they’ve also included a big dose of potassium.

    Potassium is a shortfall nutrient for Americans

    This incredibly important electrolyte mineral is not consumed in adequate amounts by most Americans. As Connie Weaver points out in her article. “Potassium and Health”.[132]

    “Until recently, humans consumed a diet high in potassium. However, with the increasing consumption of processed food, which has potassium removed, combined with a reduction in the consumption of fruits and vegetables, there has been a large decrease in potassium intake…”[133]

    Or, as Adam Drewnowski puts it in his article “Reducing the Sodium-Potassium Ratio in the US Diet: A Challenge for Public Health”:

    “Adult Americans consume too much sodium and not enough potassium.”[134]

    HIstorically, human beings have consumed way more potassium than sodium, but that is sadly no longer true.[132,135] Unless you’re eating tons of fruits and vegetables, you’re probably somewhat potassium deficient.[136]

    So how can we get more potassium? This raises an interesting issue: it’s practically impossible to get enough potassium while staying under 2,300 milligrams of sodium per day. There’s even a peer-reviewed study on this specific topic, titled “Food pattern modeling shows that the 2010 Dietary Guidelines for sodium and potassium cannot be met simultaneously,”[137] which really says it all.

    Why we want more potassium: sodium to potassium ratios

    Potassium is typically studied for its cardiovascular benefits.[132] The absolute amount is not all that matters – your ratio of sodium to potassium intake is arguably more important, as many studies have found that high potassium intake relative to sodium is associated with lower blood pressure and decreased risk of cardiovascular disease.[136,138]

    This sodium-potassium interplay is centrally implicated in the onset of hypertension,[139] and several studies have conversely shown a low intake of potassium relative to sodium is associated with a higher risk of high blood pressure cardiovascular disease.[140-144] So one strategy for optimal cardiovascular health might be to increase potassium intake rather than decrease sodium intake.[140-144]

    Potassium can also help bones, as it improves calcium retention.[145,146]

    Potassium can help drive vasodilation

    The sodium-potassium ratio is also important for endothelial cell hyperpolarization, one of the key mechanisms behind vasodilation![139,147,148] A key mechanism is through the activation of potassium channels in the smooth muscle cells that line the walls of blood vessels.

    Sodium Potassium Interaction

    A flow chart of how the modern western diet negatively affects sodium/potassium interaction, leading to poor health consequences.[139]

    When these channels are activated, potassium ions get released from the smooth muscle cells into the extracellular space. This results in the hyperpolarization of the smooth muscle cell membrane, which makes it more difficult for the cell to contract. As a result, the smooth muscle cells relax, causing the blood vessel to dilate (widen).

    Potassium also helps to counteract the effects of sodium on blood vessel tone. Sodium can cause the smooth muscle cells to contract, leading to vasoconstriction or narrowing of blood vessels. Potassium, on the other hand, helps provide balance against this, reducing blood flow constriction and promoting vasodilation.

What a unique formula!

Flavors Available

Note that, once again, Soul Performance goes with natural flavoring only, using real lemon and lime components to make it happen!

    Nitrosigine and Potassium for Nitric Oxide, Nootropics Galore, and Excellent Energy

    Soul Performance Nutrition Aura Endorphin Flow Pre-Workout

    Aura Endorphin Flow is a potent pre-workout that lives up to its name. With a clinically-backed dose of Nitrosigine as the nitric oxide anchor followed by big doses of tyrosine, taurine, choline, and caffeine, this is definitely a nootropic-focused formula that’s sure to get you feeling awesome in the gym.

    But the high amounts of electrolytes are what really separate this from the pack – and Matt’s beta testing in the PricePlow Discord tells a very interesting tale!

    We love seeing formulas that are different – not the same old citrulline and beta-alanine based formulas. Soul Performance Nutrition did that here in spades, and it’s paying off for their customers who love the minerals.

    Soul Performance Nutrition Aura Endorphin Flow – Deals and Price Drop Alerts

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    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    Soul Performance Nutrition Aura Endorphin Flow

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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    1. Helms CC, Gladwin MT and Kim-Shapiro DB (2018) Erythrocytes and Vascular Function: Oxygen and Nitric Oxide. Front. Physiol. 9:125. doi: 10.3389/fphys.2018.00125
    2. Stryer, Lubert (1995). Biochemistry, 4th Edition. W.H. Freeman and Company. p. 732
    3. Yancey, P. H. “Organic Osmolytes as Compatible, Metabolic and Counteracting Cytoprotectants in High Osmolarity and Other Stresses.” Journal of Experimental Biology, vol. 208, no. 15, 1 Aug. 2005, pp. 2819–2830
    4. Foster, April R et al. “Osmolyte transporter expression is reduced in photoaged human skin: Implications for skin hydration in aging.” Aging cell vol. 19,1 (2020): e13058. doi:10.1111/acel.13058
    5. ‌Nonappa. and Erkki Kolehmainen. “Caffeine as a Gelator.” Gels (Basel, Switzerland) vol. 2,1 9. 2 Mar. 2016, doi:10.3390/gels2010009;
    6. Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5. doi: 10.1016/j.bbrc.2014.12.005;
    7. Zhao, Guangfu et al. “Betaine in Inflammation: Mechanistic Aspects and Applications.” Frontiers in immunology vol. 9 1070. 24 May. 2018, doi:10.3389/fimmu.2018.01070
    8. Craig, Stuart AS. “Betaine in Human Nutrition.” The American Journal of Clinical Nutrition, vol. 80, no. 3, 1 Sept. 2004, pp. 539–549, 10.1093/ajcn/80.3.539.
    9. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22;
    10. Ganguly, Paul, and Sreyoshi Fatima Alam. “Role of homocysteine in the development of cardiovascular disease.” Nutrition journal vol. 14 6. 10 Jan. 2015, doi:10.1186/1475-2891-14-6;
    11. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[9]:83-89;
    12. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39;
    13. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543;
    14. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271;,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    15. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27;
    16. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d;
    17. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7;
    18. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5;
    19. Jason Michael Cholewa, et al; “The Effects of Chronic Betaine Supplementation on Body Composition and Performance in Collegiate Females: a Double-Blind, Randomized, Placebo Controlled Trial”; Journal of the International Society of Sports Nutrition; BioMed Central; 31 July 2018;
    20. Wilkinson DJ, Smeeton NJ, Watt PW. Ammonia metabolism, the brain and fatigue; revisiting the link. Prog Neurobiol. 2010 Jul;91(3):200-19. doi: 10.1016/j.pneurobio.2010.01.012;
    21. Chen, Shu, et al. “Involvement of Ammonia Metabolism in the Improvement of Endurance Performance by Tea Catechins in Mice.” Scientific Reports, vol. 10, no. 1, 8 Apr. 2020, 10.1038/s41598-020-63139-9;
    22. Ho YY, Nakato J, Mizushige T, Kanamoto R, Tanida M, Akiduki S, Ohinata K. l-Ornithine stimulates growth hormone release in a manner dependent on the ghrelin system. Food Funct. 2017 Jun 1;8(6):2110-2114. doi: 10.1039/c7fo00309a;
    23. Suminski, R. R., et al. Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. International Journal of Sport Nutrition, vol. 7, no. 1, 1997, pp. 48-60.
    24. Miyake, Mika et al. “Randomised controlled trial of the effects of L-ornithine on stress markers and sleep quality in healthy workers.” Nutrition journal vol. 13 53. 3 Jun. 2014, doi:10.1186/1475-2891-13-53;
    26. Sandler, D., et al. June 2016. “Absorption of Bonded Arginine Silicate Compared to Individual Arginine and Silicon Components.” Journal of the International Society of Sports Nutrition vol. 13;
    27. O’sullivan, D., et al. “Hepatic Zonation of the Catabolism of Arginine and Ornithine in the Perfused Rat Liver.” Biochemical Journal, vol. 330, no. Pt 2, 1 Mar. 1998, p. 627, 10.1042/bj3300627;
    28. Wu, Guoyao. “Intestinal Mucosal Amino Acid Catabolism.” The Journal of Nutrition, vol. 128, no. 8, 1 Aug. 1998, pp. 1249–1252, 10.1093/jn/128.8.1249;
    29. van de Poll, Marcel CG, et al. “Interorgan Amino Acid Exchange in Humans: Consequences for Arginine and Citrulline Metabolism.” The American Journal of Clinical Nutrition, vol. 85, no. 1, 1 Jan. 2007, pp. 167–172, 10.1093/ajcn/85.1.167;
    30. Schwedhelm, Edzard et al.; “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.”; British journal of clinical pharmacology vol. 65,1 (2008): 51-9.;
    31. Allerton, Timothy D., et al. “L-Citrulline Supplementation: Impact on Cardiometabolic Health.” Nutrients, vol. 10, no. 7, 1 July 2018, p. 921, 10.3390/nu10070921;
    32. Chen, Chaoran, et al. “Roles of Taurine in Cognitive Function of Physiology, Pathologies and Toxication.” Life Sciences, vol. 231, 15 Aug. 2019, p. 116584; doi:10.1016/j.lfs.2019.116584;
    33. Komorowski, J., Perez, S., & Sylla, S; “Arginase Inhibition by Inositol-stabilized Arginine Silicate (ASI; Nitrosigine); A Novel Mechanism by which ASI Enhances Arginine Bioavailability”; Poster Presentation. Retrieved from
    34. Moinard, C., et al. “Dose-Ranging Effects of Citrulline Administration on Plasma Amino Acids and Hormonal Patterns in Healthy Subjects: The Citrudose Pharmacokinetic Study.” British Journal of Nutrition, vol. 99, no. 4, 22 Oct. 2007, pp. 855–862, 10.1017/s0007114507841110;
    35. Kalman, D., Hewlings, S., Sylla, S., Ojalvo, S., & Komorowski, J; “An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) on cognitive flexibility”; Nutrients; 2016;
    36. Guo, Ying-Ying et al. “Taurine-mediated browning of white adipose tissue is involved in its anti-obesity effect in mice.” The Journal of biological chemistry vol. 294,41 (2019): 15014-15024. doi:10.1074/jbc.RA119.009936;
    37. Evans, M., Zakaria, N., & Marzuk, M; “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) in Preventing the Decline of Cognitive Function Caused by Strenuous Exercise”; International Society of Sports Nutrition 2018 Conference; 2018;
    38. Gills, Joshua L., et al. “Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults.” Nutrients, vol. 13, no. 12, 1 Dec. 2021, 10.3390/nu13124272;
    39. Vijaya Juturu V., Komorowski, JR. 2002. US7576132B2 – “Arginine Silicate Inositol Complex and use Thereof.” The United States Patent and Trademark Office.
    40. Ripps, H. et al. Nov. 2012. “Review: Taurine: A “Very Essential Amino Acid.” Molecular Vision vol. 18. 2673-86;
    41. Rood-Ojalvo, S. et al. Sep. 2015. “The Benefits of Inositol-Stabilized Arginine Silicate as a Workout Ingredient.” Journal of the International Society of Sports Nutrition vol. 12(S1).
    42. Uyanga, Victoria Anthony, et al. “Functional Roles of Taurine, L-Theanine, L-Citrulline, and Betaine during Heat Stress in Poultry.” Journal of Animal Science and Biotechnology, vol. 13, no. 1, Mar. 2022, doi:
    43. Ibrahim, Marwan A et al. “Therapeutic role of taurine as antioxidant in reducing hypertension risks in rats.” Heliyon vol. 6,1 e03209. 17 Jan. 2020, doi:10.1016/j.heliyon.2020.e03209;
    44. Jong, Chian Ju et al. “Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production.” Amino acids vol. 42,6 (2012): 2223-32. doi:10.1007/s00726-011-0962-7;
    45. Spriet, Lawrence L, and Jamie Whitfield. “Taurine and skeletal muscle function.” Current opinion in clinical nutrition and metabolic care vol. 18,1 (2015): 96-101. doi:10.1097/MCO.0000000000000135;
    46. Wang, Ke, et al. “Taurine Improves Neuron Injuries and Cognitive Impairment in a Mouse Parkinson’s Disease Model through Inhibition of Microglial Activation.” NeuroToxicology, vol. 83, Mar. 2021, pp. 129–136, 10.1016/j.neuro.2021.01.002;
    48. Waldron, M., et al. May 2018. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine vol. 48,5; 1247-53;
    49. Kim, Kyoung Soo et al. “Taurine Stimulates Thermoregulatory Genes in Brown Fat Tissue and Muscle without an Influence on Inguinal White Fat Tissue in a High-Fat Diet-Induced Obese Mouse Model.” Foods (Basel, Switzerland) vol. 9,6 688. 26 May. 2020, doi:10.3390/foods9060688;
    50. Ramaswamy, Lalitha et al. “Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo: Clearwater Beach, FL, USA. 9-11 June 2016.” Journal of the International Society of Sports Nutrition vol. 13, Suppl 1 33. 12 Sep. 2016, doi:10.1186/s12970-016-0144-9;
    51. Kalman, Douglas et al. “Randomized Prospective Double-Blind Studies to Evaluate the Cognitive Effects of Inositol-Stabilized Arginine Silicate in Healthy Physically Active Adults.” Nutrients vol. 8,11 736. 18 Nov. 2016, doi:10.3390/nu8110736;
    52. Komorowski, J., et al. Apr. 2016. “A Pharmacokinetic Evaluation of the Duration of Effect of Inositol- Stabilized Arginine Silicate and Arginine Hydrochloride in Healthy Adult Males.” The Journal of the Federation of American Societies for Experimental Biology vol. 30.
    53. Alvares TS, Conte CA, Paschoalin VM, Silva JT, Meirelles Cde M, Bhambhani YN, Gomes PS. Acute l-arginine supplementation increases muscle blood volume but not strength performance. Appl Physiol Nutr Metab. 2012 Feb;37(1):115-26. doi: 10.1139/h11-144. Epub 2012 Jan 17. PMID: 22251130.
    54. Álvares TS, Meirelles CM, Bhambhani YN, Paschoalin VM, Gomes PS. L-Arginine as a potential ergogenic aid in healthy subjects. Sports Med. 2011 Mar 1;41(3):233-48. doi: 10.2165/11538590-000000000-00000. PMID: 21395365.
    55. Grimble, George K. “Adverse Gastrointestinal Effects of Arginine and Related Amino Acids.” The Journal of Nutrition, vol. 137, no. 6, 1 June 2007, pp. 1693S1701S, 10.1093/jn/137.6.1693s;
    56. Castillo, L, et al. “Splanchnic Metabolism of Dietary Arginine in Relation to Nitric Oxide Synthesis in Normal Adult Man.” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 1, 1 Jan. 1993, pp. 193–197;
    57. Wu, Guoyao. “Intestinal Mucosal Amino Acid Catabolism.” The Journal of Nutrition, vol. 128, no. 8, 1 Aug. 1998, pp. 1249–1252, 10.1093/jn/128.8.1249;
    58. O’sullivan, D., et al. “Hepatic Zonation of the Catabolism of Arginine and Ornithine in the Perfused Rat Liver.” Biochemical Journal, vol. 330, no. Pt 2, 1 Mar. 1998, p. 627, 10.1042/bj3300627;
    59. Rogers, Jeffrey M et al. “Acute effects of Nitrosigine and citrulline malate on vasodilation in young adults.” Journal of the International Society of Sports Nutrition vol. 17,1 12. 24 Feb. 2020, doi:10.1186/s12970-020-00343-y
    60. Evans, M. et al. July 2020. “Inositol-Stabilized Arginine Silicate Improves Post Exercise Cognitive Function in Recreationally Active, Healthy Males: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.” Journal of Exercise and Nutrition vol. 3,3; (full-text PDF)
    61. Munz, P. A; “A California flora and supplement”; University of California Press: Berkeley, CA, 1973; p 547;
    62. Hadley, W. J.; Gisvold, O. “A phytochemical study of Eriodictyon angustifolium, Nuttley”; J. Am. Pharm. Assoc. Sci. Educ. 1944, 33, 275–7;
    63. Mödinger, Yvonne, et al. “A Food Supplement with Antioxidative Santa Herba Extract Modulates Energy Metabolism and Contributes to Weight Management.” Journal of Medicinal Food, 13 July 2021, 10.1089/jmf.2021.0016.
    64. Santos, Tanila & Miranda, Jonatan & Teixeira, Lucimara & Aiastui, Ana & Matheu, Ander & Gambero, Alessandra & Portillo, María & Ribeiro, Marcelo. (2018). Yerba Mate Stimulates Mitochondrial Biogenesis and Thermogenesis in High Fat Diet-Induced Obese Mice. Molecular Nutrition & Food Research. 62. 1800142. 10.1002/mnfr.201800142.
    65. Sanders LM, Zeisel SH; “Choline: Dietary Requirements and Role in Brain Development;” Nutrition today; 2007;42(4):181-186;
    66. Sanders, Lisa M, and Steven H Zeisel. “Choline: Dietary Requirements and Role in Brain Development.” Nutrition today vol. 42,4 (2007): 181-186. doi:10.1097/01.NT.0000286155.55343.fa
    67. Purves D, Augustine GJ, Fitzpatrick D, et al.; “Neuroscience;” 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Acetylcholine.
    68. Hasselmo ME; “The role of acetylcholine in learning and memory;”Curr Opin Neurobiol. 2006;16(6):710–715;
    69. Jones BE; “From waking to sleeping: neuronal and chemical substrates”. Trends Pharmacol. Sci.; 2005; 26 (11): 578–86;
    70. Guieu, Régis et al. “Hyperhomocysteinemia and cardiovascular diseases.” Annales de biologie clinique vol. 80,1 (2022): 7-14. doi:10.1684/abc.2021.1694
    71. Marcus L, et al; “Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance;” J Int Soc Sports Nutr; 2017;14:39;
    72. Scientific Research Publishing; “Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women.”; Advances in Infectious Diseases; Scientific Research Publishing; 20 June 2012;
    73. Fioravanti M, Buckley AE. Citicoline (Cognizin) in the treatment of cognitive impairment. Clin Interv Aging. 2006;1(3):247–251. doi:10.2147/ciia.2006.1.3.247;
    74. Silveri, MM et al; “Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy”; NMR Biomed. 2008 Nov;21(10):1066-75. doi: 10.1002/nbm.1281;
    75. Cognizin® Citicoline Ingredient Information; Kyowa Hakko USA: 2020;
    76. Secades, JJ; “Citicoline: pharmacological and clinical review, 2016 update;” Rev Neurol; 2017;
    77. Cappelletti, Simone et al. “Caffeine: cognitive and physical performance enhancer or psychoactive drug?.” Current neuropharmacology vol. 13,1 (2015): 71-88. doi:10.2174/1570159X13666141210215655;
    78. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010);
    79. Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170;
    80. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance.”; J Int Soc Sports Nutr 7, 5 (2010);
    81. Diepvens, K et al; “Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea;” American Journal of Physiology; 2007;
    82. Norager, C B, et al; “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.”; Clinical Endocrinology; U.S. National Library of Medicine; Aug. 2006;
    83. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008 Dec;33(6):1319-34. doi: 10.1139/H08-130;
    84. Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS. Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. 2017 Jul;20(6):369-377. doi: 10.1080/1028415X.2016.1144845;
    85. McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine’s effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016 Dec;71:294-312. doi: 10.1016/j.neubiorev.2016.09.001;
    86. Klaassen EB, de Groot RH, Evers EA, Snel J, Veerman EC, Ligtenberg AJ, Jolles J, Veltman DJ. The effect of caffeine on working memory load-related brain activation in middle-aged males. Neuropharmacology. 2013 Jan;64:160-7. doi: 10.1016/j.neuropharm.2012.06.026;
    87. KUO, Chia-Hua, et al. Anti-Aging Method and Composition. Accessed 2 Apr. 2023.
    88. Zheng, K. et al. Mar. 2012/ “Salidroside Stimulates the Accumulation of HIF-1α Protein Resulted in the Induction of EPO Expression: A Signaling via Blocking the Degradation Pathway in Kidney and Liver Cells.” European Journal of Pharmacology vol. 679,1-3; 34-9.
    89. Panossian, A. et al. June 2010. “Rosenroot (Rhodiola Rosea): Traditional Use, Chemical Composition, Pharmacology, and Clinical efficacy.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology vol. 17,7. 481-93.
    90. Van Diermen, D. et al. Mar. 2009. “Monoamine Oxidase Inhibition by Rhodiola Rosea L. Roots.” Journal of Ethnopharmacology vol. 122,2; 397-401.
    91. Dimpfel, W. et al. May 2018. “Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola Rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory.” Frontiers in Pharmacology vol. 9.
    92. Cropley, M. et al. Dec. 2015. “The Effects of Rhodiola Rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms.” Phytotherapy Research: PTR vol. 29,12; 1934-9.
    93. Darbinyan, V. et al. 2007. “Clinical Trial of Rhodiola Rosea L. Extract SHR-5 in the Treatment of Mild to Moderate Depression.” Nordic Journal of Psychiatry vol. 61,5; 343-8.
    94. Hou, C.-W., Lee, S.-D., et. al. Plos One. “Improved Inflammatory Balance of Human Skeletal Muscle during Exercise after Supplementations of the Ginseng-Based Steroid Rg1.” Jan. 2015.10(1);
    95. Lee SH. et al.; “Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway.”; Scientific Reports; 2017;
    96. Guerrero-Romero, Fernando, and Martha Rodríguez-Morán. “Magnesium Improves the Beta-Cell Function to Compensate Variation of Insulin Sensitivity: Double-Blind, Randomized Clinical Trial.” European Journal of Clinical Investigation, vol. 41, no. 4, 17 Jan. 2011, pp. 405–410, 10.1111/j.1365-2362.2010.02422.x;
    97. Hatzistavri, L. S., et al. “Oral Magnesium Supplementation Reduces Ambulatory Blood Pressure in Patients with Mild Hypertension.” American Journal of Hypertension, vol. 22, no. 10, 1 Oct. 2009, pp. 1070–1075, 10.1038/ajh.2009.126;
    98. Kawano, Yuhei, et al. “Effects of Magnesium Supplementation in Hypertensive Patients.” Hypertension, vol. 32, no. 2, Aug. 1998, pp. 260–265, 10.1161/01.hyp.32.2.260;
    99. Guerrero-Romero, F, and M Rodríguez-Morán. “The Effect of Lowering Blood Pressure by Magnesium Supplementation in Diabetic Hypertensive Adults with Low Serum Magnesium Levels: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.” Journal of Human Hypertension, vol. 23, no. 4, 20 Nov. 2008, pp. 245–251, 10.1038/jhh.2008.129;
    100. Rodriguez-Moran, M., and F. Guerrero-Romero. “Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic Control in Type 2 Diabetic Subjects: A Randomized Double-Blind Controlled Trial.” Diabetes Care, vol. 26, no. 4, 1 Apr. 2003, pp. 1147–1152, 10.2337/diacare.26.4.1147;
    101. Mooren, F. C., et al. “Oral Magnesium Supplementation Reduces Insulin Resistance in Non-Diabetic Subjects – a Double-Blind, Placebo-Controlled, Randomized Trial.” Diabetes, Obesity and Metabolism, vol. 13, no. 3, 24 Jan. 2011, pp. 281–284, 10.1111/j.1463-1326.2010.01332.x;
    102. Golf, S.W., et al. Cardiovascular Drugs and Therapy, vol. 12, no. 2suppl, 1998, pp. 197–202, 10.1023/a:1007708918683;
    103. Simental-Mendía LE, Sahebkar A, Rodríguez-Morán M, Guerrero-Romero F. A systematic review and meta-analysis of randomized controlled trials on the effects of magnesium supplementation on insulin sensitivity and glucose control. Pharmacol Res. 2016 Sep;111:272-282. doi: 10.1016/j.phrs.2016.06.019;
    104. Hruby A, Guasch-Ferré M, Bhupathiraju SN, Manson JE, Willett WC, McKeown NM, Hu FB. Magnesium Intake, Quality of Carbohydrates, and Risk of Type 2 Diabetes: Results From Three U.S. Cohorts. Diabetes Care. 2017 Dec;40(12):1695-1702. doi: 10.2337/dc17-1143;
    105. Fang X, Han H, Li M, Liang C, Fan Z, Aaseth J, He J, Montgomery S, Cao Y. Dose-Response Relationship between Dietary Magnesium Intake and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Regression Analysis of Prospective Cohort Studies. Nutrients. 2016 Nov 19;8(11):739. doi: 10.3390/nu8110739;
    106. Zhao B, Deng H, Li B, Chen L, Zou F, Hu L, Wei Y, Zhang W. Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis. Diabetes Metab Res Rev. 2020 Mar;36(3):e3243. doi: 10.1002/dmrr.3243;
    107. Carpenter, Thomas O., et al. “A Randomized Controlled Study of Effects of Dietary Magnesium Oxide Supplementation on Bone Mineral Content in Healthy Girls.” The Journal of Clinical Endocrinology & Metabolism, vol. 91, no. 12, Dec. 2006, pp. 4866–4872, 10.1210/jc.2006-1391;
    108. Ebrahimi, Elham, et al. “Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms.” Journal of Caring Sciences, vol. 2012, no. 4, pp. 183–189, 10.5681/jcs.2012.026;
    109. Quaranta, S., et al. “Pilot Study of the Efficacy and Safety of a Modified-Release Magnesium 250 Mg Tablet (Sincromag) for the Treatment of Premenstrual Syndrome.” Clinical Drug Investigation, vol. 27, no. 1, 2007, pp. 51–58, 10.2165/00044011-200727010-00004;
    110. Walker, Ann F., et al. “Magnesium Supplementation Alleviates Premenstrual Symptoms of Fluid Retention.” Journal of Women’s Health, vol. 7, no. 9, Nov. 1998, pp. 1157–1165, 10.1089/jwh.1998.7.1157;
    111. Facchinetti, F., et al. “Oral Magnesium Successfully Relieves Premenstrual Mood Changes.” Obstetrics and Gynecology, vol. 78, no. 2, 1991, pp. 177–181;
    112. Zhang, Yijia et al. “Can Magnesium Enhance Exercise Performance?.” Nutrients vol. 9,9 946. 28 Aug. 2017, doi:10.3390/nu9090946;
    113. Welch, Ailsa A, et al. “Dietary Magnesium Is Positively Associated with Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association between Circulating C-Reactive Protein and Muscle Mass in Women.” Journal of Bone and Mineral Research, vol. 31, no. 2, 11 Sept. 2015, pp. 317–325, 10.1002/jbmr.2692;
    114. Simental-Mendia LE, Sahebkar A, Rodriguez-Moran M, Zambrano-Galvan G, Guerrero-Romero F. Effect of Magnesium Supplementation on Plasma C-reactive Protein Concentrations: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Curr Pharm Des. 2017;23(31):4678-4686. doi: 10.2174/1381612823666170525153605;
    115. Steward CJ, Zhou Y, Keane G, Cook MD, Liu Y, Cullen T. One week of magnesium supplementation lowers IL-6, muscle soreness and increases post-exercise blood glucose in response to downhill running. Eur J Appl Physiol. 2019 Dec;119(11-12):2617-2627. doi: 10.1007/s00421-019-04238-y;
    116. Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019 Aug 16;11(8):1927. doi: 10.3390/nu11081927;
    117. Chiu HY, Yeh TH, Huang YC, Chen PY. Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician. 2016 Jan;19(1):E97-112.
    118. von Luckner A, Riederer F. Magnesium in Migraine Prophylaxis-Is There an Evidence-Based Rationale? A Systematic Review. Headache. 2018 Feb;58(2):199-209. doi: 10.1111/head.13217;
    119. Shahrami A, Assarzadegan F, Hatamabadi HR, Asgarzadeh M, Sarehbandi B, Asgarzadeh S. Comparison of therapeutic effects of magnesium sulfate vs. dexamethasone/metoclopramide on alleviating acute migraine headache. J Emerg Med. 2015 Jan;48(1):69-76. doi: 10.1016/j.jemermed.2014.06.055;
    120. Montain, Scott J et al. “Sweat mineral-element responses during 7 h of exercise-heat stress.” International journal of sport nutrition and exercise metabolism vol. 17,6 (2007): 574-82. doi:10.1123/ijsnem.17.6.574
    121. Strazzullo P., Leclercq C.; “Sodium.” Advanced Nutrition; March 2014; 5(2) 188-190;
    122. Valentine, V. 2007. “The Importance of Salt in the Athlete’s Diet.” Current Sports Medicine Reports vol. 6,4 (2007): 237-40.
    123. Rondon H, Badireddy M. Hyponatremia. [Updated 2022 Jan 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:
    124. Hooper L, Martin N, Jimoh OF, Kirk C, Foster E, Abdelhamid AS. Reduction in saturated fat intake for cardiovascular disease. Cochrane Database Syst Rev. 2020;8(8):CD011737. 2020 Aug 21. doi:10.1002/14651858.CD011737.pub3;
    125. O’Donnell MJ, Yusuf S, Mente A, Gao P, Mann JF, Teo K, McQueen M, Sleight P, Sharma AM, Dans A, Probstfield J, Schmieder RE. Urinary sodium and potassium excretion and risk of cardiovascular events. JAMA. 2011 Nov 23;306(20):2229-38. doi: 10.1001/jama.2011.1729;
    126. Rod S. Taylor, Kate E. Ashton, Tiffany Moxham, Lee Hooper, Shah Ebrahim, Reduced Dietary Salt for the Prevention of Cardiovascular Disease: A Meta-Analysis of Randomized Controlled Trials (Cochrane Review), American Journal of Hypertension, Volume 24, Issue 8, August 2011, Pages 843–853,
    127. Melinda Wenner Moyer. “It’s Time to End the War on Salt.” Scientific American, 8 July 2011;
    128. Cook NR, Cutler JA, Obarzanek E, Buring JE, Rexrode KM, Kumanyika SK, Appel LJ, Whelton PK. Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP). BMJ. 2007 Apr 28;334(7599):885-8. doi: 10.1136/bmj.39147.604896.55;
    129. Stockand, James D. “Vasopressin regulation of renal sodium excretion.” Kidney international vol. 78,9 (2010): 849-56. doi:10.1038/ki.2010.276
    130. ‌Kitada, Kento et al. “High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.” The Journal of clinical investigation vol. 127,5 (2017): 1944-1959. doi:10.1172/JCI88532
    131. Bie, P. “Blood volume, blood pressure and total body sodium: internal signalling and output control.” Acta physiologica (Oxford, England) vol. 195,1 (2009): 187-96. doi:10.1111/j.1748-1716.2008.01932.x
    132. Weaver, Connie M. “Potassium and Health.” Advances in Nutrition, vol. 4, no. 3, 1 May 2013, pp. 368S377S, 10.3945/an.112.003533;
    133. Fj, He, and MacGregor Ga. “Beneficial Effects of Potassium on Human Health.” Physiologia Plantarum, 1 Aug. 2008;
    134. Drewnowski, Adam, et al. “Reducing the Sodium-Potassium Ratio in the US Diet: A Challenge for Public Health.” The American Journal of Clinical Nutrition, vol. 96, no. 2, 3 July 2012, pp. 439–444, 10.3945/ajcn.111.025353;
    135. Houston, Mark C. “The Importance of Potassium in Managing Hypertension.” Current Hypertension Reports, vol. 13, no. 4, 15 Mar. 2011, pp. 309–317, 10.1007/s11906-011-0197-8;
    136. Fulgoni, Victor L., et al. “Foods, Fortificants, and Supplements: Where Do Americans Get Their Nutrients?” The Journal of Nutrition, vol. 141, no. 10, 24 Aug. 2011, pp. 1847–1854, 10.3945/jn.111.142257;
    137. Maillot, Matthieu, et al. “Food Pattern Modeling Shows That the 2010 Dietary Guidelines for Sodium and Potassium Cannot Be Met Simultaneously.” Nutrition Research (New York, N.y.), vol. 33, no. 3, 1 Mar. 2013, p. 188, 10.1016/j.nutres.2013.01.004;
    138. Cook, Nancy R. “Joint Effects of Sodium and Potassium Intake on Subsequent Cardiovascular Disease.” Archives of Internal Medicine, vol. 169, no. 1, 12 Jan. 2009, p. 32, 10.1001/archinternmed.2008.523;
    139. Adrogué, Horacio J., and Nicolaos E. Madias. “Sodium and Potassium in the Pathogenesis of Hypertension.” New England Journal of Medicine, vol. 356, no. 19, 10 May 2007, pp. 1966–1978, 10.1056/nejmra064486;
    140. Dyer, Alan R., et al. “Urinary Electrolyte Excretion in 24 Hours and Blood Pressure in the INTERSALT Study.” American Journal of Epidemiology, vol. 139, no. 9, 1 May 1994, pp. 940–951, 10.1093/oxfordjournals.aje.a117100;
    141. Elliott, P., et al. “Intersalt Revisited: Further Analyses of 24 Hour Sodium Excretion and Blood Pressure within and across Populations.” BMJ, vol. 312, no. 7041, 18 May 1996, pp. 1249–1253,, 10.1136/bmj.312.7041.1249;
    142. Cook, N. R., et al. “Effect of Change in Sodium Excretion on Change in Blood Pressure Corrected for Measurement Error. The Trials of Hypertension Prevention, Phase I.” American Journal of Epidemiology, vol. 148, no. 5, 1 Sept. 1998, pp. 431–444, 10.1093/oxfordjournals.aje.a009668;
    143. Khaw, K T, and E Barrett-Connor. “The Association between Blood Pressure, Age, and Dietary Sodium and Potassium: A Population Study.” Circulation, vol. 77, no. 1, Jan. 1988, pp. 53–61, 10.1161/01.cir.77.1.53;
    144. Xie, J. X., et al. “The Relationship between Urinary Cations Obtained from the INTERSALT Study and Cerebrovascular Mortality.” Journal of Human Hypertension, vol. 6, no. 1, 1 Feb. 1992, pp. 17–21;
    145. Lemann, Jacob, et al. “Potassium Administration Increases and Potassium Deprivation Reduces Urinary Calcium Excretion in Healthy Adults.” Kidney International, vol. 39, no. 5, May 1991, pp. 973–983, 10.1038/ki.1991.123;
    146. Gregory, Naina Sinha, et al. “Potassium Citrate Decreases Bone Resorption in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind Clinical Trial” Endocrine Practice, vol. 21, no. 12, Dec. 2015, pp. 1380–1386, 10.4158/ep15738.or;
    147. Haddy, Francis J., et al. “Role of Potassium in Regulating Blood Flow and Blood Pressure.” American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 290, no. 3, 1 Mar. 2006, pp. R546-552, 10.1152/ajpregu.00491.2005;
    148. Amberg, Gregory C., et al. “Modulation of the Molecular Composition of Large Conductance, Ca2+ Activated K+ Channels in Vascular Smooth Muscle during Hypertension.” Journal of Clinical Investigation, vol. 112, no. 5, 1 Sept. 2003, p. 717, 10.1172/JCI18684;

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