MitoBurn in the Bottle: How NNB’s Highly-Soluble L-BAIBA Will Transform Beverages

MitoBurn L-BAIBA from NNB Nutrition is remarkably soluble at 737g/L — making it perfect for RTDs and liquid supplements! While most ingredients struggle in beverages, MitoBurn thrives.

The supplement industry has been evolving rapidly, with beverages and ready-to-drink (RTD) formulas gaining significant market share over traditional powders and pills. Yet formulators face a persistent challenge: keeping it novel! Too many potent ingredients simply don’t play well in liquid form.

Enter MitoBurn (L-β-aminoisobutyric acid, or L-BAIBA), NNB Nutrition’s premier exercise mimetic that’s not only metabolically powerful but also exceptionally soluble. For whatever reason, the novel ingredient’s been forgotten in the shift to beverages. We’re not sure, but we’re confident it can be a next-level game-changer for liquid supplements.

As beverages continue to dominate industry growth, having stable, highly-soluble ingredients becomes increasingly critical. Most ingredients struggle to dissolve adequately, but it turns out that MitoBurn shatters these limitations with solubility levels that vastly outperform traditional supplement staples. This property opens exciting new possibilities for formulators looking to create effective, convenient, and different liquid products.

In this article, we explain the solubility factor of MitoBurn L-BAIBA, discuss the science behind the ingredient, and recap NNB Nutrition’s growing beverage-stable platform.

Before we dive in, stay ahead of supplement innovation with PricePlow’s NNB Nutrition alerts, so you can get notified about cutting-edge ingredients like MitoBurn:

MitoBurn: Setting New Standards for Ingredient Solubility

MitoBurn from NNB Nutrition has been tested out to be a pure form of L-BAIBA, and has completely disrupted the supplement market!

When formulators work with liquid supplements, solubility isn’t just a nice-to-have feature, it’s absolutely essential. Poor solubility leads to sedimentation, inconsistent dosing, and poor consumer experiences. This is why MitoBurn’s excellent water solubility is a big story, and one that should be told.

NNB’s scientists have found that MitoBurn can dissolve at an impressive 737 grams per liter of water at 68 degrees Celsius. Realize that MitoBurn is generally dosed at 250-500 milligrams, so that is a massive number, meaning the solubility is excellent. This upper limit would create a solution too thick for practical use, but NNB’s R&D team confirms that 500-600 grams per liter (still, a ridiculously high amount) creates viable solutions for commercial applications.

To put this in perspective:

The extraordinary solubility listed above puts MitoBurn in the same league as highly water-soluble compounds like glucose and carnitine. This makes perfect biological sense L-BAIBA is naturally produced in the body and functions in the bloodstream, like carnitine and glucose do. By contrast, popular supplements like creatine monohydrate (13g/L) and beta-alanine (80g/L) don’t even come close — and they require higher doses to achieve clinical amounts.

What does this mean for brands and consumers? Simply put, MitoBurn can be effectively incorporated into liquid supplements at clinical doses without stability, precipitation, or texture issues that plague so many other ingredients.

Speaking of carnitine, there is one brand that was ahead of the curve here:

MuscleSport CarniShred + MitoBurn: A Liquid Success Story

The theoretical advantages of MitoBurn’s solubility are already in practice by innovative brands. A prime example is MuscleSport’s CarniShred + MitoBurn, a liquid fat-burning formula that leverages MitoBurn’s exceptional stability in liquid.

This product pairs MitoBurn with liquid L-carnitine, CaloriBurn GP (grains of paradise extract), and other metabolic support ingredients in a ready-to-drink “liquid shot” format. Its success demonstrates the practical application of MitoBurn in commercial liquid supplements, offering consumers the convenience of a liquid delivery system without sacrificing efficacy.

By exploring MuscleSport CarniShred + MitoBurn, formulators can see a real-world example of how MitoBurn seamlessly integrates into liquid formulations, providing inspiration for their own product development efforts.

The Science Advantage: Why L-BAIBA May Work Better in Liquid

Beyond its impressive solubility, there are scientific reasons why L-BAIBA may actually be more effective in liquid form. L-BAIBA is a signaling molecule that works through various pathways to create an “exercise-like” signal throughout the body.^[1]

NNB Nutrition demonstrates how beverage makers can create naturally sweetened functional drinks without compromising taste. Their “Rethink The Drink” concept showcases SweetVantage technology alongside clinical doses of GeniusPure Alpha-GPC, SalidroPure, and TyroPure.

When consumed in a liquid form, L-BAIBA can:

1. Achieve faster absorption: Liquid formulations bypass the dissolution step required for powders and capsules.
2. Potentially enhance bioavailability: Pre-dissolved ingredients often demonstrate improved absorption kinetics compared to solid forms that must first dissolve in the digestive tract.
3. Create consistent dosing: L-BAIBA’s high solubility ensures uniform distribution throughout the liquid, preventing the inconsistent dosing that can occur with less soluble compounds.
4. Improve customer compliance: Liquid supplements fit more easily into daily routines, potentially improving adherence to supplementation protocols.

The exercise-mimetic effects of L-BAIBA – which include promoting white adipose tissue browning, enhancing fat oxidation, and supporting glucose metabolism — are all dependent on the compound reaching its target tissues.^[2] Liquid delivery provides a direct pathway to maximize these benefits.

Beyond MitoBurn: NNB’s Complete Beverage Platform

MitoBurn doesn’t exist in isolation… it’s part of NNB Nutrition’s novel approach to beverage innovation. Their “Rethink The Drink” (RTD) concept showcases how brands can create science-backed, great-tasting functional beverages using NNB’s portfolio of beverage-stable ingredients.

NNB Nutrition revolutionizes nootropic beverages with their brain health platform! GeniusPure Alpha-GPC, MitoPrime, SalidroPure and more – finally solving stability issues that have plagued liquid nootropics. XPO NRG proves these ingredients can transform the RTD market.

MitoBurn fits perfectly within this ecosystem, alongside other innovative ingredients like:

• MitoPrime (L-Ergothioneine): A potent “longevity vitamin” and antioxidant that protects against oxidative stress and supports cellular energy production
• GeniusPure (Alpha-GPC): A high-yield, non-clumping form of Alpha-GPC that enhances cognitive function
• SalidroPure (Salidroside): A pure, sustainable alternative to Rhodiola that enhances mental and physical performance (developed and made by NNB Nutrition and sold by NutriScience)
• SweetVantage: A breakthrough natural sweetener that provides clean sweetness without the bitter aftertaste of traditional stevia

Together, these ingredients form NNB’s Brain Health Platform, a growing solution for creating functional, nootropic beverages that taste great and deliver real benefits.

Formulation Possibilities: Beyond Traditional RTDs

MitoBurn’s exceptional solubility opens possibilities far beyond standard RTD beverages:

NNB Nutrition revolutionizes natural sweeteners with SweetVantage. A 3-year, $2.5M project delivers clean-tasting stevia that covers the entire palate. Perfect for beverages and powders.

• Energy shots

  The high solubility of MitoBurn allows for concentrated “shot” formats (2-4oz) that deliver clinical doses in a convenient format. Imagine a pre-workout or metabolism shot containing effective doses of MitoBurn along with other functional ingredients – all in a small, portable format.

• Sports nutrition beverages

  Recovery drinks, intra-workout formulas, and hydration solutions can all benefit from MitoBurn’s metabolic properties and exceptional stability in liquid. This is where we’re seeing the most growth

• Functional coffees and teas

  The neutral taste profile and stability of MitoBurn make it ideal for enhancing everyday beverages like coffee and tea. Brands can create premium functional coffee and tea products with added metabolic benefits without compromising taste.

• Functional water enhancers

  

  NNB Nutrition has finally brought us a trusted and tested form of L-BAIBA, which we call an “exercise signal” that kickstarts incredible metabolic processes! It’s known as MitoBurn and it helps kick-start the ‘exercise program’!

  Concentrated drops or powders designed to add to water represent another exciting application. MitoBurn’s solubility ensures it will mix easily and completely when added to beverages.

• Liquid capsules

  For brands preferring a more traditional delivery method, MitoBurn’s solubility makes it perfect for liquid capsules, which can provide enhanced absorption compared to powder-filled alternatives. These are tougher to create, so we don’t see them as often… but it is possible.

So what is MitoBurn L-BAIBA, anyway?

The BAIBA Revolution: From Research to Reality

L-BAIBA was discovered as an “exercise molecule” — a metabolite naturally produced during physical activity that helps signal the body to burn fat and improve metabolic health.^[3] Research has demonstrated impressive benefits, including:

NNB Nutrition shined at SupplySide West 2024 with innovations like XPO NRG, GeniusPure, and SweetVantage, setting new standards in nutrition — with much more to come!

• Conversion of white fat to brown/beige fat
• Enhanced fatty acid oxidation in liver and muscle
• Improved glucose tolerance
• Reduced inflammation via AMPK-PPARδ pathway
• Protection against disuse-induced bone and muscle loss

MitoBurn is the commercial manifestation of this research. It’s a pure, stable form of L-BAIBA (the active isomer) that’s now available for supplement formulations. Its exceptional solubility is just one aspect of what makes it unique.

What’s exciting is how MitoBurn’s liquid-friendly properties align with the ways L-BAIBA naturally functions in the body. As a signaling molecule that travels through the bloodstream, it’s inherently designed to be highly water-soluble! By formulating MitoBurn in liquid products, manufacturers are essentially mimicking how this molecule naturally exists and functions in the body. And that makes sense, given that it’s an exercise mimetic.

Why Now is the Time for Liquid MitoBurn Formulations

Several market trends make this the perfect moment for brands to consider liquid MitoBurn products:

1. The beverage market is booming: Beverages and ready-to-drink supplements have seen consistent growth as consumers prioritize convenience.
2. Exercise mimetics are gaining traction: As consumers learn more about exercise-activated molecules like L-BAIBA, demand for these ingredients continues to grow. NNB’s upcoming “mimetic” campaign will educate more on these benefits.
3. Clean label movement: MitoBurn’s natural origins (as a metabolite produced by exercising muscle) align perfectly with consumer preferences for natural, clean-label products.
4. Functional beverage explosion: The line between supplements and beverages is blurring, creating new opportunities for innovative formulations. We’re well beyond slapping some caffeine and cheap B-vitamins into a can now!
5. Science-backed formulations: Consumers increasingly demand evidence-based ingredients, and MitoBurn’s research backing satisfies this requirement.

For brands looking to differentiate in a crowded market, MitoBurn offers a unique combination of scientific credibility, functional benefits, and exceptional formulation properties.

Conclusion: The Future of MitoBurn is Liquid

Shawn Wells and Dustin Elliott of NNB Nutrition join the PricePlow Podcast for Episode #152 to discuss innovative ingredients that capture ongoing trends like GLP-1 and MPS. We also get into Dustin’s trip to China, NNB’s participation in XPO NRG with MitoPrime, and Shawn’s psychedelic experiences and his post-trip supplement stack.

The incredible solubility of MitoBurn represents more than just a technical specification, it opens a world of possibilities that simply weren’t viable years ago. NNB is the company that made BAIBA viable (with the active L- isomer), and they’re set to shock the industry again. In an industry where innovation often comes from novel ingredient combinations rather than novel delivery systems, MitoBurn’s liquid-friendly properties offer a rare opportunity to truly differentiate.

As Shawn Wells and Dustin Elliott discussed on the PricePlow Podcast, NNB Nutrition continues to push the boundaries of ingredient development by solving real formulation challenges. MitoBurn exemplifies this approach: taking a scientifically valuable molecule and making it practical for commercial applications.

For brands looking to create the next generation of liquid supplements, MitoBurn provides the perfect foundation — a metabolically active ingredient with the stability and solubility needed for beverages. As consumers increasingly seek convenient, effective supplements that fit seamlessly into their daily routines, MitoBurn-based beverages can meet this demand perfectly.

The future of supplements is flowing in a liquid direction, and with MitoBurn, that future looks exceptionally promising.