Nutrex Outlift BURN Fat Burning Pre-Workout with Metabolyte

Published on July 12, 2023 · Updated July 26, 2023 by Mike Roberto | No Comments

Since its founding in 2002, Nutrex Research has earned its place as a mainstay brand in the supplement industry. The Nutrex team originally set out to design the highest quality supplements possible, for the most discerning and demanding consumers.

Nutrex Outlift burn

The Nutrex legend started with Lipo-6, an impressive catalog of fat burner supplements. Since then, Nutrex has branched out to absolutely crush it in a variety of product categories, including pre-workouts, supplemental proteins, and amino acids. Nutrex isn’t just popular in the states – you can find Nutrex products in over 100 countries worldwide.

Aside from the Lipo-6 line, some of the most successful Nutrex products include Outlift, IsoFit, and Vitadapt. In 2023, they brought in Chris Waldrum, who’s kicking off And today, we’re getting back to the pre-workout category, with a new twist on the Outlift workout series — one that’s more metabolic:

Introducing Nutrex Outlift Burn – with Metabolyte

To kick off the 2023 Nutrex Rebirth, the team is first coming out with Outlift Burn, a fat burning pre-workout combination that’s absolutely jam packed with powerful ingredients.

Plus, we’ll see the appearance of some unfamiliar, yet exciting fat-burner ingredients – Metabolyte, which is making its debut in this formula, and Hemerocallis extract, an obscure one we haven’t seen in quite a while.

Nutrex really pulled out all the stops on this one!

Let’s get into how this works, but first, check the PricePlow news and deals:

Nutrex Outlift Burn – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

This area is reserved for Team PricePlow's upcoming videos.

Subscribe to our channel and sign up for notifications so you catch it when it goes live!

Subscribe to PricePlow on YouTube!

Nutrex Outlift Burn Ingredients

In a single 1 scoop (19 gram) serving of Outlift Burn from Nutrex, you get the following:

Pump and Strength Matrix

  • L-Citrulline – 6,000 mg

    Citrulline is the most popular nitric oxide (NO) boosting ingredient[1] in the supplement industry right now. It owes its popularity to the fact that it’s safe, inexpensive, and effective.

    As you can see from our inset diagram, arginine is actually a more direct precursor to NO than citrulline – so why not take arginine instead? The answer is that citrulline is much more bioavailable than arginine.[2,3]

    By increasing your body’s NO production, citrulline can trigger a mechanism called vasodilation, which causes your blood vessels to expand in diameter. This leads to improved circulation, lower heart rate, and reduced blood pressure.[4-6]

    Improved circulation means that nutrients get delivered to your cells, and metabolic wastes removed, significantly more efficiently than normal. This can benefit multiple dimensions of athletic performance (especially endurance) and speed up recovery.

    Ornithine and Ammonia in the Nitric Oxide Cycle

    Citrulline participates in two key metabolic cycles, the nitric oxide cycle and the urea cycle. Both are important for athletic performance and recovery.[7]

    Research shows that citrulline supplementation can:

    • Increase power by improving oxygen utilization[8]
    • Prolong athletic endurance by as much as 50%[9]
    • Reduce muscular soreness following a workout[9]
    • Upregulate growth hormone (GH), an anabolic hormone[10]
    • Inhibit protein catabolism[11]
    • Increase protein synthesis[12,13]

    Nutrex Outlift Burn

    Note that the dose used in Nutrex Outlift Burn is 6,000 mg – twice the 3,000 mg dose we used to see in pre-workouts, but a dose that’s become more common. This is a good thing, since citrulline’s benefits have been shown to be dose-dependent.[14]

  • Beta-Alanine – 3,200 mg

    Beta-alanine is a popular ergogenic aid. It can increase athletic performance by combining with the amino acid L-histidine to form carnosine, a dipeptide molecule that helps remove lactic acid from your muscles. This matters because the accumulation of lactic acid causes muscular fatigue,[15] so the faster your body can get rid of it, the longer you can sustain an athletic effort.

    The reason to take the carnosine precursor beta-alanine instead of carnosine itself is, again, that the precursor is significantly more bioavailable. Moreover, since histidine is abundant in common foods, beta-alanine availability is almost always the bottleneck on your body’s carnosine production, making beta-alanine supplementation a very effective strategy for upregulating carnosine.[16,17]

    Two meta-analyses, looking at over 40 peer-reviewed studies, found that beta-alanine is best at increasing endurance during exercises lasting 30 seconds to 10 minutes.[18,19]

    Beta Alanine Meta Analysis

    The 2012 meta analysis showed who beta alanine may work best for, but future data expanded our knowledge.[18]

    Tingles? No sweat

    Most people get a tingling sensation in their face and upper body upon taking beta-alanine. Don’t worry about this, as a recent safety review concluded that it’s harmless.[20]

    Long story short, beta alanine is great for boosting endurance, which will allow your muscles to take on extra volume. But you still need to get it done yourself — it won’t burn extra calories for you.

    So far, we’ve got two classic pre-workout ingredients. Soon we’re going to get into weight loss territory:

That Feel Good Energy Blend

  • L-Tyrosine – 2,000 mg

    Tyrosine is excellent supplement for two important goals:

    Nutrex Logo

    Nutrex Research as been around since 2002, and they continue to put out innovative, effective products!

    First, tyrosine is really good for supporting thyroid function – it’s a precursor to triiodothyronine (T3) and thyroxine (T4), your body’s two main thyroid hormones.[21,22] Thyroid support can be important for athletes and bodybuilders, as both strenuous physical activity[23,24] and caloric restriction[25] can downregulate thyroid function.

    Second, tyrosine is a precursor to key neurotransmitters like dopamine, adrenaline, and noradrenaline.[26-28] Generally speaking, more of these neurotransmitters can translate into better mental clarity, focus, and motivation. Plus, adrenaline and noradrenaline can help burn fat.[29]

    Also great for sleep deprivation

    Sleep deprivation is no joke, but it does happen occasionally. In these cases, we need something that can help us perform in spite of our fatigue – and tyrosine seems to be great for this, too. According to a study conducted by the U.S. military, tyrosine is actually better at restoring cognitive function during sleep deprivation than caffeine is![30,31]

  • Acetyl-L-Carnitine – 1,000 mg

    Acetyl-L-carnitine (ALCAR) is the supplement industry’s go-to form of L-carnitine for nootropic effects. It has neuroprotective, neurotropic, and even anti-depressive effects.[32]

    ALCAR Choline Acetylcholine Synthesis

    Huge synergy in this formula between the choline and acetyl L-carnitine! If you’re low on acetyl groups, your choline may not get to the acetylcholine that you want. ALCAR (Acetyl L-Carnitine) listed above helps with that bottleneck.

    Carnitine’s basic mechanism of action is to help move energy substrates like glucose and fatty acids into your cells’ mitochondria, which supports adenosine triphosphate (ATP) synthesis. Since ATP is your cells’ usable energy, their gasoline if you will, increasing ATP availability can improve cellular function.[33]

    Among other forms of carnitine, ALCAR in particular is especially good at improving the metabolic function of neurons. This is because ALCAR is great at crossing the brain blood barrier,[34] which makes it more bioavailable to your brain.

    Animal studies have found that ALCAR can enhance the synaptic plasticity of mammals’ brains, and facilitate learning.[35]

    But a really compelling human study showed that men and women over the age of 65 with mild cognitive impairment who took ALCAR did much better on a cognitive test than those who took a placebo.[36]

    Ultimately, how much carnitine you need depends on your diet and how aggressively you’re training. It’s most prevalently found in meat, so those who need the ingredient most (especially for fat loss) are those who are either vegan/vegetarian,[37-40] older,[41,42] or athletes training incredibly hard and depleting themselves.[43] Most Outlift Burn users will fall into the latter category.

    If you’re looking to learn more about the research behind carnitine consumption in athletes, read the incredible 2018 review titled “L-Carnitine Supplementation in Recovery after Exercise”.[43]

  • Alpha-GPC 50% (Alpha-Glyceryl Phosphoryl Choline) – 600 mg

    AlphaGPC is a form of choline, an essential B vitamin used by your body to build and maintain the phospholipid bilayer membranes that surround all your body’s cells.[44] Choline is also necessary for the intercellular signaling functions carried out by those membranes.[45]

    Alpha GPC Caffeine Jump Power

    Caffeine and Alpha GPC are great for brain boosting, but they’re also awesome for enhancing performance.

    Choline’s nootropic properties come from its status as a precursor to acetylcholine, a crucial neurotransmitter that facilitates learning and memory.[46] We at PricePlow often refer to acetylcholine as the learning neurotransmitter because of how important it is for these processes – particularly memory consolidation.

    Taking choline supplements can increase your body’s production of choline, leading to improved cognitive performance.[47,48] For nootropic purposes, alpha-GPC is a popular of choline to use, since it’s much better at crossing the blood-brain barrier than other forms.[49]

    There’s also evidence that alpha-GPC can increase strength in a short period of time.[50]

    Choline is also an important methyl donor, and can help keep methionine under control. This is important because if methionine blood levels get to high, it can lead to significant cardiovascular disease.[51]

    Choline and fat loss / diet

    With regards to diet, choline is incredibly important for fat metabolism,[52-55] and we’ve seen high doses of other forms support improved weight loss,[56] so there’s also hope for some added support here. Even better, choline and carnitine are synergistic for dieters since choline boosts carnitine retention,[57-59] and both are in Outlift Burn.

  • Caffeine Anhydrous – 300 mg (of ~355mg total)

    Caffeine is a stimulant capable of crossing the blood-brain barrier,[60] which gives it a high degree of activity in the brain.

    It’s popular for improving mood, sharpening focus, and enhancing athletic performance, while making the user feel more energetic.[61] Caffeine helps fight fatigue by inhibiting the action of adenosine, an ATP byproduct that accumulates in the brain while we’re awake and causes us to feel tired as it builds up.[62,63]

    But caffeine also gives us more energy in a very literal sense, by cranking up cellular metabolism. Caffeine does this by inhibiting an enzyme called phosphodiesterase, which breaks down a messenger molecule called cyclic adenosine monophosphate (cAMP).[61-65] Since cAMP tells your cells to burn glucose and fatty acids for energy, raising cAMP levels this way speeds up your metabolism, enabling you to burn more calories in a day.

    High Dose Caffeine Performance

    Known since 1991, very high dose caffeine can seriously boost performance.[66] As you can see, it’s quite variable amongst users – future research would show that caffeine’s effects depend on your genotype.

    Fat burner

    Caffeine is particularly good at burning fat,[67] with some research showing that it can increase your body’s rate of fat burning by as much as 50% above baseline.[68]

    According to a 2020 meta-analysis, doses as small as 3 milligrams of caffeine per kilogram of body weight are enough to increase the amount of fat your body burns during exercise.[69]

    Athletic performance

    Research shows that caffeine can improve strength, speed, power, and endurance.[61,62,64,67,68] This means caffeine is a great ergogenic aid – one of the cheapest, safest, and most effective among nutritional supplements.

    When it comes to mental performance, caffeine has been shown to improve attentiveness, alertness, reaction time, and working memory.[70-72]

    Note that the total amount of caffeine in Nutrex Outlift Burn is 355 milligrams – we have a bit of slower caffeine coming up next:

  • Dicaffeine Malate – 75 mg (yielding ~55mg of ~355mg total)

    Dicaffeine malate shares identical effects with caffeine anhydrous. The primary distinction lies in the way caffeine is “buffered” through its binding with malic acid, resulting in a slower rate of metabolism compared to the anhydrous form. As a consequence, dicaffeine malate acts as a slow-acting form of caffeine, while anhydrous caffeine acts rapidly.

    The concept behind combining these two forms of caffeine in the same formula is to create a more gradual and sustained increase in caffeine levels in the bloodstream, thus mitigating the risk of a severe crash that sometimes follows the initial stimulant effect.

    Note that dicaffeine malate is about 73% caffeine by weight, so the total amount of caffeine in Nutrex Outlift Burn is 355 milligrams once calculating that this yields roughly 55 milligrams worth.

Burn That FCKN Fat Blend

  • Metabolyte (as sodium phaseolusate and potassium phaseolusate) – 1,500 mg

    Nutrex Outlift Burn

    Now it’s time for the new ingredient: Metabolyte. It’s labeled as both sodium phaseolusate and potassium phaseolusate – two terms that are currently not indexed in major scientific databases.

    As best we can tell, the phaseolusate term is derived from the genus Phaseolus, which includes several species of beans like kidney beans, navy beans, and black beans. These species contain certain compounds called phaseolusates that function to defend the plant against water and parasites.[73]

    These plants also produce a compound called dodecanedioic acid (DDDA),[73-75] a medium-chain dicarboxylic acid that serves as an energy substrate in both plant and animal metabolism.[76]

    As best we can tell, this is really dodecanedioic acid sodium salt and dodecanedioic acid potassium salt. This is basically a supplemental source of DDDA, bound to two classic minerals we love to supplement.

    So what are the benefits of DDDA? Research has demonstrated the following:

    • A 1998 study found that intravenous DDDA helped type 2 diabetes manage blood glucose and energy levels.[77] The DDDA seemed to work by optimizing insulin signaling and lowering blood lactate.[77]
      • Intravenous Dodecanedioic Acid Diabetics Blood Sugar Insulin

      Intravenous Dodecanedioic Acid for diabetics (who aren’t on insulin) helps regulate blood sugar levels.[77]

    • A 2006 study found that 40 grams of DDDA, taken before a workout, helped diabetics finish a 2 hour long workout, and reduced muscle fatigue afterwards.[78] The mechanism here was helping the diabetics overcome metabolic inflexibility by serving as an energy substrate during exercise.[78]

      The researchers concluded the following:

      In conclusion, [dodecanedioic acid] seems to be a suitable energy substrate during exercise, since it reduces muscle fatigue, is rapidly oxidized, and does not stimulate insulin secretion, which implies that lipolysis is not inhibited as reported after glucose ingestion.[78]

    • In another study on diabetics published in 2013, dodecanedioic acid was again found to reduce muscle fatigue during exercise.[76] The researchers suggested that it improved energy utilization and metabolic flexibility.

      DDDA may provide necessary substrates for ATP synthesis and mitochondrial oxidation that aren’t generated enough in overweight individuals.

    • Finally, a 2013 analysis noted that greater dodecanedioic acid levels are associated with lower blood pressure in individuals with chronic kidney disease.[79]

    Obviously, we can’t use it intravenously for dietary supplements, so it needs to be bound to something to become stable as powder. The lowest-weight options that support health while keeping the DDDA yields high are simple minerals — sodium and potassium!

    A “fat burning electrolyte”?

    All in all, it seems that we have a type of “fat burning electrolyte” here that allows for more metabolic flexibility, which means the body can switch more easily between glucose and fat oxidation — a goal everyone should have.

    Note: It’s “C12”, but not to be confused with the MCT lauric acid

    Note that in the above research, dodecanedioic acid (DDDA) is referred to as C12 due to its molecular structure containing 12 carbon atoms. However, it’s not the same as the C12 medium chain triglyceride (MCT), lauric acid.

    This is completely different. Instead of the medium-chain triglycerides, we’re talking about the medium‐chain dicarboxylic acids (medium-chain DAs)![76]

    This is a bit of a new paradigm here – DDDA isn’t really a protein, carbohydrate, ketone, or fat. It’s a dicarboxylic acid, and some consider it to be the “fifth macronutrient” after the above four. It seems to be metabolized by multiple organs and not just the liver, which can support metabolic flexibility in those with liver dysfunction (a quickly growing population).

    The big picture on DDDA is that it seems to help drive ATP synthesis and mitochondria respiration in people who don’t generate the necessary substrates for these processes – particularly in overweight people.

    There’s some promise here, and we’re excited about the research supporting muscular endurance and glucose reduction, but we’ll need more information to see what doses are efficacious.

  • Hemerocallis Fulva (Flower) Extract – 200 mg

    Hemerocallis fulva known colloquially as orange day lily, is a synergistic fat burner. By this we mean that Hemerocallis has no lipolytic (fat burning) activity on its own, but can significantly increase lipolysis when combined with phosphodiesterase inhibitors.[80]

    Given that we have two big-time phosphodiesterase inhibitors in Nutrex Outlift Burn – caffeine and theobromine (from Cocoabuterol, discussed next) – the inclusion of this ingredient makes a ton of sense. In fact, most fat burner supplements have multiple phosphodiesterase inhibitors these days, so maybe Hemerocallis is poised to make a comeback, and Chris Waldrum and his team have hit a bit of a bonus here.

  • Cocoabuterol (Theobroma cacao L. extract) (seed) – 100 mg

    Cocoabuterol is an extract of the cocoa plant standardized to contain at least 50% cocoa alkaloids by weight. These alkaloids are able to suppress appetite, increase energy, upregulate thermogenesis, and even improve your mood.[81,82]

    Arguably the most important of these alkaloids is theobromine, which resembles caffeine in its mechanism and effects. Like caffeine, theobromine inhibits phosphodiesterase and blocks the action of adenosine, thus helping fight fatigue and speed up cellular metabolism.[81,83,84]

    However, cocoa also contains powerful polyphenol antioxidants with anti-inflammatory, cardioprotective, and antioxidant properties.[81,82]

    Both the alkaloids and the polyphenols in cocoa have been shown to improve dopamine signaling,[85] which can help improve mood and cognition and protect your neurons from stress.[85]

    Cocoabuterol

    This is a popular cocoa extract that goes beyond theobomrine thanks also to the N-coumaroyldopamine and N-caffeoyldopamine inside.

    Fat burner

    While upregulating cAMP through phosphodiesterase inhibition can definitely help burn fat by increasing overall calorie burn, the theobromine in cocoa extract has also been shown to change body fat composition in a highly favorable way. Specifically, theobromine helps drive the conversion of white adipose tissue (WAT) to brown adipose tissue (BAT).[86] Since BAT is a metabolically active type of fat that burns calories via thermogenesis, this conversion has the effect of increasing your basal metabolic rate.

    Theobromine also stimulates fat burning in existing BAT, by activating the brown adipocytes within.[86]

  • CaloriBurn GP (Aframomum Melegueta Extract) (seed) (12.5% 6-Paradol) – 40 mg

    CaloriBurn

    Finally, a grains of paradise extract that actually passes lab tests for all clinical constituents!

    CaloriBurn GP from NNB Nutrition is another ingredient that’s great at increasing the activity of brown adipose tissue (BAT). It’s an extract of the plant Aframomum melegueta, also known as grains of paradise, that’s standardized for a phenolic ketone called 6-paradol.

    Animal research has shown that injections of pure 6-paradol activates thermogenesis in existing brown adipose tissue (BAT).[87] Increased thermogenic activity in BAT causes a faster metabolism and calorie burn,[88-90] leading to easier fat burn and, potentially, faster weight loss.

    But increased BAT activity also has some metabolic benefits that are independent of weight loss – since the brown adipocytes pull glucose and fatty acids out of your blood to burn them for energy, increased BAT activity means better glycemic control and blood triglycerides.[91]

    Human research on grains of paradise

    One study in women found that grains of paradise was great for burning visceral fat, a type of body fat that has outsized negative effects on cardiometabolic health, despite accounting for a small minority of overall body fat.[92] The dose used in this study was only 30 mg/day – just 75% of the dose present in Nutrex Outlift Burn!

    CaloriBurn

    NNB Nutrition’s CaloriBurn GP has 12.5% 6-Paradol, but uses pure grains of paradise to keep all of the active constituents.

    In another study, a 40 milligram dose of grains of paradise (GP) caused a significant increase in basal metabolic rate[93] of about 400 calories per day 30 minutes after ingestion. The striking thing about this study is that it was conducted in healthy young men, a group whose metabolic function is generally pretty solid to begin with. And that was after only a single dose of GP!

    Grains of Paradise Visceral Fat

    Grains of paradise supplementation has been shown to significantly reduce visceral fat levels.[92]

    Note that with regards to the second study, we aren’t saying they actually burned 400 more calories that day – we’re saying that the rate of calorie burn 30 minutes after ingestion was 400 calories per day higher. Area under the curve (AUC) analysis showed that they burned about 25 more calories per hour during the 2-hour study period.[93]

  • GBBGO (Gamma-Butyrobetaine Hydrochloride) – 30 mg

    Gamma-butyrobetaine (GBB) is a carnitine precursor. It gets converted into carnitine by an enzyme called gamma-butyrobetaine dioxygenase (BBD).[94]

    We already have a gram of carnitine in Nutrex Outlift Burn, so why would we want to take GBB as well? The answer is that GBB works synergistically with supplemental carnitine to keep blood carnitine levels high. To understand how, we need to talk about chemical equilibrium.

    GBB alters your body’s chemical carnitine equilibrium

    According to Le Chatelier’s principle, also called the law of chemical equilibrium,[95] we can change the baseline concentration of a chemical reagent by modifying that of a chemical product, or vice-versa.

    GBB Carnitine

    GBB gets converted to carnitine, and vice-versa, until the two compounds reach chemical equilibrium. Excess GBB gets turned into excess carnitine – excess carnitine gets turned into excess GBB.

    When it comes to carnitine, equilibrium is achieved by special bacterial species in your gut.[96] Specifically, once BDD turns GBB into carnitine, these bacteria turn carnitine back into GBB.

    If your carnitine levels rise above baseline – say, after taking a gram of carnitine in Nutrex Outlift Burn – then your body will start balancing your carnitine levels by converting some of that extra back into GBB. Put simply, when the right side of the chemical equation in our inset image gets too big, your body will start equalizing it by moving stuff to the left.

    Nutrex Outlift Burn

    So if you want the right side of the equation to stay big, you’ve got to add to the left side as well as the right.

    That means in order for supplemental carnitine to be maximally effective, you’ve got to take GBB in addition to carnitine.

    The familiar bioavailability problem

    As we’ve already mentioned several times in this article, precursors to molecules we’re trying to target tend to be more bioavailable than the target molecules themselves. That turns out to be the case with carnitine and GBB – there’s a limit on how much supplemental carnitine we can absorb, and going over it tends to cause unwanted gastrointestinal symptoms.[97,98]

    GBB is well tolerated though, making GBB supplementation an excellent strategy for indirectly raising carnitine levels.

    GBB and nitric oxide

    GBB also turns out to be a great NO booster, just like citrulline.[99] So this GBB can give you more of the NO-associated benefits mentioned in the citrulline section.

    GBB sweats?

    Most people report that GBB causes them to sweat. Opinions on this are divided – some love it, others not as much. But if you’re buying a supplement with the word “Burn” in the name, we’ve got to believe you’re ready to feel it!

    The exact mechanism by which GBB induces sweating has yet to be identified, but regardless, sweating can have certain health benefits. For example, sweating is one of your body’s primary detoxification mechanisms. Your body uses sweat to eliminate toxic xenoestrogenic and carcinogenic compounds like bisphenol A (BPA),[100] polychlorinated biphenyls (PCBs),[101] persistent organic pollutants, and heavy metals.[102]

  • Rauwolfia vomitoria Extract (root) (std. 90% Rauwolscine) – 1.5 mg

    GBB isn’t the only ingredient that might amp up your sweat!

    Rauwolfia contains a stimulant alkaloid called rauwolscine, also known as alpha yohimbine because of its similarity to yohimbine.

    Chris Waldrum PricePlow Podcast #091 Nutrex Research Rebrand

    Chris Waldrum returns to the PricePlow Podcast for Episode #091 to discuss leading the Nutrex Research Rebrand

    So to understand rauwolscine, let’s talk for a minute about yohimbine, which is an alpha-2 antagonist. This means that it stimulates adrenaline and noradrenaline receptors. In doing this, yohimbine can suppress appetite,[94] speed up weight loss,[95] and improve focus.[96]

    Rauwolscine has the same mechanism of action. It’s been shown to prevent fat storage and increase cellular energy availability.[97]

    As is the case with stimulant alkaloids in general, Tolerance of rauwolscine varies by individual. Most people feel fine on rauwolscine, but some might experience jitters or even anxiety. If you have that latter response to Nutrex Outlift Burn, it’s probably the rauwolscine that you’re reacting to.

    Still, rauwolscine has great benefits for metabolic function and fat loss, so it’s not something we want to dismiss out of hand.[98] If you’re not sure about taking this, talk to your doctor about it first.

Maximum Absorption

  • BioPerine [(Piper nigrum extract) (fruit)] – 5 mg

    Piperine, the main bioactive constituent of BioPerine black pepper extract,[103-106] inhibits certain enzymes that ordinarily break down nutrients in your stomach. With these enzymes inhibited, those nutrients are free to pass through your stomach intact, giving them a chance to be absorbed into your bloodstream in your intestines.[99]

    Bioperine

    In other words, BioPerine is a bioavailability enhancer – it increases the absorption of other ingredients in Nutrex Outlift Burn. This both increases the effectiveness of the supplement, and in the long run, helps you get the most bang for your buck.

    But that’s not all — piperine is also a potent antioxidant[102] and can increase insulin sensitivity and prevent fatty liver.[100,101] That may be an even better reason to include it in a fat-burning pre-workout like Outlift Burn!

Flavors Available

Nutrex Outlift has some of the best and most underrated flavors on the pre-workout market. Outlift Burn will have a bit more spice in it (thanks to CaloriBurn GP and BioPerine), so here’s an updated list of flavors:

    Conclusion: Outlift Burn Goes Big on the Burn

    Wow! With ingredients like GBB, CaloriBurn, and Cocoabuterol all making an appearance in the same formula, Nutrex Outlift Burn is a pre-workout with really heavy fat-burner support. And we can’t forget the synergistic effects of choline and carnitine as well. At the same time, we have generous doses of citrulline and beta-alanine, which are definitely the typical pre-workout heavy hitters.

    The really notable thing about this formula is obviously the appearance of Metabolyte, an intriguing ingredient that we still don’t know enough about — but we’ve done our best to get you all of the information on this new class of ingredient so that you can make an informed decision.

    We’ve seen enough that we will be trying it, and we’re excited to hear consumer feedback on this one. What a great start to the Nutrex Rebirth.

    Nutrex Outlift Burn – Deals and Price Drop Alerts

    Get Price Alerts

    No spam, no scams.

    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

    No Comments | Posted in | Tagged , , , , , , , , , , , , , , , , , , , , , , .

    References

    1. Morita, Masahiko, et al; “Oral Supplementation with a Combination of L-Citrulline and L-Arginine Rapidly Increases Plasma L-Arginine Concentration and Enhances NO Bioavailability.”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 7 Nov. 2014; https://www.ncbi.nlm.nih.gov/pubmed/25445598
    2. Ochiai, Masayuki, et al; “Short-Term Effects of L-Citrulline Supplementation on Arterial Stiffness in Middle-Aged Men.”; International Journal of Cardiology; U.S. National Library of Medicine; 8 Mar. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21067832
    3. Agarwal, Umang et al; “Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.”; The Journal of nutrition; vol. 147,4; 2017; 596-602; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368575/
    4. Orozco-Gutiérrez JJ, Castillo-Martínez L, Orea-Tejeda A, Vázquez-Díaz O, Valdespino-Trejo A, Narváez-David R, Keirns-Davis C, Carrasco-Ortiz O, Navarro-Navarro A, Sánchez-Santillán R. Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction. Cardiol J. 2010;17(6):612-8; https://pubmed.ncbi.nlm.nih.gov/21154265/
    5. Wong A, Alvarez-Alvarado S, Jaime SJ, Kinsey AW, Spicer MT, Madzima TA, Figueroa A. Combined whole-body vibration training and l-citrulline supplementation improves pressure wave reflection in obese postmenopausal women. Appl Physiol Nutr Metab. 2016 Mar;41(3):292-7. doi: 10.1139/apnm-2015-0465; https://cdnsciencepub.com/doi/10.1139/apnm-2015-0465
    6. Alsop P, Hauton D. Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure. Eur J Appl Physiol. 2016 Sep;116(9):1651-61. doi: 10.1007/s00421-016-3418-7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983290/
    7. Rashid, Jahidur, et al. “Therapeutic Potential of Citrulline as an Arginine Supplement: A Clinical Pharmacology Review.” Pediatric Drugs, vol. 22, no. 3, 6 Mar. 2020, pp. 279–293, 10.1007/s40272-020-00384-5. https://link.springer.com/article/10.1007/s40272-020-00384-5
    8. Bailey, Stephen J, et al; “l-Citrulline Supplementation Improves O2 Uptake Kinetics and High-Intensity Exercise Performance in Humans.”; Journal of Applied Physiology (Bethesda, Md. : 1985); U.S. National Library of Medicine; 15 Aug. 2015; https://www.ncbi.nlm.nih.gov/pubmed/26023227
    9. Pérez-Guisado, Joaquín, and Philip M Jakeman; “Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness.”; Journal of Strength and Conditioning Research; U.S. National Library of Medicine; May 2010; https://www.ncbi.nlm.nih.gov/pubmed/20386132
    10. Sureda A, Córdova A, Ferrer MD, Pérez G, Tur JA, Pons A. L-citrulline-malate influence over branched chain amino acid utilization during exercise. Eur J Appl Physiol. 2010 Sep;110(2):341-51. doi: 10.1007/s00421-010-1509-4; https://link.springer.com/article/10.1007/s00421-010-1509-4
    11. Breuillard C, Cynober L, Moinard C. Citrulline and nitrogen homeostasis: an overview. Amino Acids. 2015 Apr;47(4):685-91. doi: 10.1007/s00726-015-1932-2; https://link.springer.com/article/10.1007/s00726-015-1932-2
    12. Jourdan M, Nair KS, Carter RE, Schimke J, Ford GC, Marc J, Aussel C, Cynober L. Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet – A pilot study. Clin Nutr. 2015 Jun;34(3):449-56. doi: 10.1016/j.clnu.2014.04.019; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309748/
    13. Bahri S, Zerrouk N, Aussel C, Moinard C, Crenn P, Curis E, Chaumeil JC, Cynober L, Sfar S. Citrulline: from metabolism to therapeutic use. Nutrition. 2013 Mar;29(3):479-84. doi: 10.1016/j.nut.2012.07.002; https://www.sciencedirect.com/science/article/abs/pii/S0899900712002584
    14. Schwedhelm, Edzard, et al. “Pharmacokinetic and Pharmacodynamic Properties of Oral L-Citrulline and L-Arginine: Impact on Nitric Oxide Metabolism.” British Journal of Clinical Pharmacology, vol. 65, no. 1, Jan. 2008, pp. 51–59, 10.1111/j.1365-2125.2007.02990.x. https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2007.02990.x
    15. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    16. Harris, R. C., et al. “The Absorption of Orally Supplied β-Alanine and Its Effect on Muscle Carnosine Synthesis in Human Vastus Lateralis.” Amino Acids, vol. 30, no. 3, 24 Mar. 2006, pp. 279–289, 10.1007/s00726-006-0299-9; https://pubmed.ncbi.nlm.nih.gov/16554972/
    17. Dunnett, M., and R. C. Harris. “Influence of Oral ß-Alanine and L-Histidine Supplementation on the Carnosine Content of Thegluteus Medius.” Equine Veterinary Journal, vol. 31, no. S30, July 1999, pp. 499–504, 10.1111/j.2042-3306.1999.tb05273.x; https://pubmed.ncbi.nlm.nih.gov/10659307/
    18. Hobson, R M, et al; “Effects of β-Alanine Supplementation on Exercise Performance: a Meta-Analysis.”; Amino Acids; Springer Vienna; July 2012; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
    19. Saunders, Bryan, et al. “β-Alanine Supplementation to Improve Exercise Capacity and Performance: A Systematic Review and Meta-Analysis.” British Journal of Sports Medicine, vol. 51, no. 8, 18 Oct. 2016, pp. 658–669; https://bjsm.bmj.com/content/51/8/658.long
    20. Dolan, Eimear, et al. “A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.” Advances in Nutrition, vol. 10, no. 3, 13 Apr. 2019, pp. 452–463, 10.1093/advances/nmy115; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520041/
    21. Mullur, Rashmi et al. “Thyroid hormone regulation of metabolism.” Physiological reviews vol. 94,2 (2014): 355-82. doi:10.1152/physrev.00030.2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044302/
    22. Rousset, Bernard. “Chapter 2 Thyroid Hormone Synthesis And Secretion.” Endotext. U.S. National Library of Medicine, 2 Sept. 2015; https://www.ncbi.nlm.nih.gov/books/NBK285550/
    23. Rousset, Bernard, et al. “Chapter 2 Thyroid Hormone Synthesis and Secretion.” Nih.gov, MDText.com, Inc., 2 Sept. 2015. https://www.ncbi.nlm.nih.gov/books/NBK285550/
    24. Mullur, Rashmi, et al. “Thyroid Hormone Regulation of Metabolism.” Physiological Reviews, vol. 94, no. 2, Apr. 2014, pp. 355–382, 10.1152/physrev.00030.2013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044302/
    25. Wadden TA, Mason G, Foster GD, Stunkard AJ, Prange AJ. Effects of a very low calorie diet on weight, thyroid hormones and mood. Int J Obes. 1990 Mar;14(3):249-58; https://pubmed.ncbi.nlm.nih.gov/2341229/
    26. Mishra, Akanksha, et al. “Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson’s Disease.” Journal of Experimental Neuroscience, vol. 12, Jan. 2018, p. 117906951877982, 10.1177/1179069518779829. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985548/
    27. Rajeev Dalal, and Dejan Grujic. “Epinephrine.” Nih.gov, StatPearls Publishing, 2 Apr. 2019. https://www.ncbi.nlm.nih.gov/books/NBK482160/
    28. Smith, Matthew D, and Christopher V Maani. “Norepinephrine.” Nih.gov, StatPearls Publishing, 23 July 2019. https://www.ncbi.nlm.nih.gov/books/NBK537259/
    29. Ans, Armghan H, et al. “Neurohormonal Regulation of Appetite and Its Relationship with Stress: A Mini Literature Review.” Cureus, 23 July 2018, 10.7759/cureus.3032. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150743/
    30. Attipoe, Selasi, et al. “Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature.” Military Medicine, vol. 180, no. 7, July 2015, pp. 754–765, 10.7205/milmed-d-14-00594; https://academic.oup.com/milmed/article/180/7/754/4160625
    31. Pomeroy, Diane E., et al. “A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel.” Nutrients, vol. 12, no. 2, 20 Feb. 2020, p. 545, 10.3390/nu12020545; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071459/
    32. Traina, Giovanna; “The Neurobiology of Acetyl-L-Carnitine.”; Frontiers in Bioscience (Landmark Edition); U.S. National Library of Medicine; 1 June 2016; https://www.ncbi.nlm.nih.gov/pubmed/27100509
    33. Eder, K, et al; “Free and Total Carnitine Concentrations in Pig Plasma after Oral Ingestion of Various L-Carnitine Compounds.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Jan. 2005; https://www.ncbi.nlm.nih.gov/pubmed/15830915
    34. Parnetti, L, et al; “Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type”; Eur J Clin Pharmacol. 1992; 42(1):89-93; https://www.ncbi.nlm.nih.gov/pubmed/1541322
    35. Ando, S, et al; “Enhancement of Learning Capacity and Cholinergic Synaptic Function by Carnitine in Aging Rats.”; Journal of Neuroscience Research; U.S. National Library of Medicine; 15 Oct. 2001; https://www.ncbi.nlm.nih.gov/pubmed/11592123
    36. Passeri, M, et al; “Acetyl-L-Carnitine in the Treatment of Mildly Demented Elderly Patients.”; International Journal of Clinical Pharmacology Research; U.S. National Library of Medicine; 1990; https://www.ncbi.nlm.nih.gov/pubmed/2201659
    37. Krajcovicová-Kudlácková, M., et al. “Correlation of Carnitine Levels to Methionine and Lysine Intake.” Physiological Research, vol. 49, no. 3, 2000, pp. 399–402; https://pubmed.ncbi.nlm.nih.gov/11043928/
    38. Lombard, K A, et al. “Carnitine Status of Lactoovovegetarians and Strict Vegetarian Adults and Children.” The American Journal of Clinical Nutrition, vol. 50, no. 2, 1 Aug. 1989, pp. 301–306, 10.1093/ajcn/50.2.301; https://academic.oup.com/ajcn/article-abstract/50/2/301/4651007
    39. Krajcovicová-Kudlácková, M., et al. “Correlation of Carnitine Levels to Methionine and Lysine Intake.” Physiological Research, vol. 49, no. 3, 2000, pp. 399–402; https://pubmed.ncbi.nlm.nih.gov/11043928/
    40. Rebouche, Charles J. “Carnitine Function and Requirements during the Life Cycle.” The FASEB Journal, vol. 6, no. 15, Dec. 1992, pp. 3379–3386, 10.1096/fasebj.6.15.1464372; https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.6.15.1464372
    41. Malaguarnera, Mariano, et al. “Serum Carnitine Levels in Centenarians.” Clinical Drug Investigation, vol. 17, no. 4, 1999, pp. 321–327, 10.2165/00044011-199917040-00008; https://link.springer.com/article/10.2165/00044011-199917040-00008
    42. Malaguarnera, Mariano, et al. “L-Carnitine Treatment Reduces Severity of Physical and Mental Fatigue and Increases Cognitive Functions in Centenarians: A Randomized and Controlled Clinical Trial.” The American Journal of Clinical Nutrition, vol. 86, no. 6, 1 Dec. 2007, pp. 1738–1744, 10.1093/ajcn/86.5.1738; https://pubmed.ncbi.nlm.nih.gov/18065594/
    43. Fielding, Roger, et al. “L-Carnitine Supplementation in Recovery after Exercise.” Nutrients, vol. 10, no. 3, 13 Mar. 2018, p. 349, 10.3390/nu10030349. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/
    44. Sanders LM, Zeisel SH; “Choline: Dietary Requirements and Role in Brain Development;” Nutrition today; 2007;42(4):181-186; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518394/
    45. Sanders, Lisa M, and Steven H Zeisel. “Choline: Dietary Requirements and Role in Brain Development.” Nutrition today vol. 42,4 (2007): 181-186. doi:10.1097/01.NT.0000286155.55343.fa https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518394/
    46. Purves D, Augustine GJ, Fitzpatrick D, et al.; “Neuroscience;” 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Acetylcholine. https://www.ncbi.nlm.nih.gov/books/NBK11143/
    47. Hasselmo ME; “The role of acetylcholine in learning and memory;”Curr Opin Neurobiol. 2006;16(6):710–715; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659740/
    48. Jones BE; “From waking to sleeping: neuronal and chemical substrates”. Trends Pharmacol. Sci.; 2005; 26 (11): 578–86; https://www.ncbi.nlm.nih.gov/pubmed/16183137
    49. Marcus L, et al; “Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance;” J Int Soc Sports Nutr; 2017;14:39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629791/
    50. Bellar, David, et al. “The Effect of 6 Days of Alpha Glycerylphosphorylcholine on Isometric Strength.” Journal of the International Society of Sports Nutrition, vol. 12, 17 Nov. 2015, doi:10.1186/s12970-015-0103-x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650143/
    51. Guieu, Régis et al. “Hyperhomocysteinemia and cardiovascular diseases.” Annales de biologie clinique vol. 80,1 (2022): 7-14. doi:10.1684/abc.2021.1694 https://www.jle.com/fr/revues/abc/e-docs/hyperhomocysteinemia_and_cardiovascular_diseases_321902/article.phtml
    52. Zeisel, S. H. & Blusztajn, J. K.; “Choline and human nutrition;” Ann. Rev. Nutr; 1994;14:269–296; https://www.researchgate.net/profile/Steven_Zeisel/publication/15251760_Choline_and_Human_Nutrition/links/00463522603a36807a000000/Choline-and-Human-Nutrition.pdf
    53. Zeisel, Steven H. “Choline: Critical Role during Fetal Development and Dietary Requirements in Adults.” Annual Review of Nutrition, vol. 26, 2006, pp. 229–250, 10.1146/annurev.nutr.26.061505.111156; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441939/
    54. Kuksis, A., and S. Mookerjea. “Choline.” Nutrition Reviews, vol. 36, no. 7, 27 Apr. 2009, pp. 201–207, 10.1111/j.1753-4887.1978.tb07359.x; https://academic.oup.com/nutritionreviews/article-abstract/36/7/201/1831331
    55. da Costa, Kerry-Ann, et al. “Effects of Prolonged (1 Year) Choline Deficiency and Subsequent Re-Feeding of Choline on 1,2-Sn-Diradylglycerol, Fatty Acids and Protein Kinase c in Rat Liver.” Carcinogenesis, vol. 16, no. 2, 1995, pp. 327–334, 10.1093/carcin/16.2.327; https://academic.oup.com/carcin/article-abstract/16/2/327/348681
    56. Elsawy, Gehan, et al. “Effect of Choline Supplementation on Rapid Weight Loss and Biochemical Variables among Female Taekwondo and Judo Athletes.” Journal of Human Kinetics, vol. 40, no. 1, 1 Mar. 2014, pp. 77–82, doi:10.2478/hukin-2014-0009; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096089/
    57. Dodson WL, Sachan DS. Choline supplementation reduces urinary carnitine excretion in humans. Am J Clin Nutr. 1996;63(6):904-910. https://www.ncbi.nlm.nih.gov/pubmed/8644685
    58. Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr. 2003;133(1):84-89. http://jn.nutrition.org/content/133/1/84.long
    59. Daily JW 3rd, Sachan DS. Choline supplementation alters carnitine homeostasis in humans and guinea pigs. J Nutr. 1995;125(7):1938-1944. https://www.ncbi.nlm.nih.gov/pubmed/7616311
    60. Ikeda-Murakami K, Tani N, Ikeda T, Aoki Y, Ishikawa T. Central Nervous System Stimulants Limit Caffeine Transport at the Blood-Cerebrospinal Fluid Barrier. Int J Mol Sci. 2022 Feb 7;23(3):1862. doi: 10.3390/ijms23031862. PMID: 35163784; PMCID: PMC8836437. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836437/
    61. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010); https://link.springer.com/article/10.1186/1550-2783-7-5
    62. Cappelletti, Simone et al. “Caffeine: cognitive and physical performance enhancer or psychoactive drug?.” Current neuropharmacology vol. 13,1 (2015): 71-88. doi:10.2174/1570159X13666141210215655; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462044/
    63. Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170; https://www.sciencedirect.com/science/article/abs/pii/016501739290012B
    64. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance.”; J Int Soc Sports Nutr 7, 5 (2010); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777221/
    65. Diepvens, K et al; “Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea;” American Journal of Physiology; 2007; https://journals.physiology.org/doi/full/10.1152/ajpregu.00832.2005
    66. Graham, T. E., and L. L. Spriet. “Performance and Metabolic Responses to a High Caffeine Dose during Prolonged Exercise.” Journal of Applied Physiology, vol. 71, no. 6, Dec. 1991, pp. 2292–2298, doi:10.1152/jappl.1991.71.6.2292; https://pubmed.ncbi.nlm.nih.gov/1778925/
    67. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008 Dec;33(6):1319-34. doi: 10.1139/H08-130; https://cdnsciencepub.com/doi/10.1139/H08-130
    68. Norager, C B, et al; “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.”; Clinical Endocrinology; U.S. National Library of Medicine; Aug. 2006; https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2006.02579.x
    69. Collado-Mateo D, Lavín-Pérez AM, Merellano-Navarro E, Coso JD. Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis. Nutrients. 2020 Nov 24;12(12):3603. doi: 10.3390/nu12123603. PMID: 33255240; PMCID: PMC7760526. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760526/
    70. Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS. Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. 2017 Jul;20(6):369-377. doi: 10.1080/1028415X.2016.1144845; https://www.tandfonline.com/doi/abs/10.1080/1028415X.2016.1144845
    71. McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine’s effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016 Dec;71:294-312. doi: 10.1016/j.neubiorev.2016.09.001; https://www.sciencedirect.com/science/article/pii/S0149763416300690
    72. Klaassen EB, de Groot RH, Evers EA, Snel J, Veerman EC, Ligtenberg AJ, Jolles J, Veltman DJ. The effect of caffeine on working memory load-related brain activation in middle-aged males. Neuropharmacology. 2013 Jan;64:160-7. doi: 10.1016/j.neuropharm.2012.06.026; https://www.sciencedirect.com/science/article/abs/pii/S0028390812002845
    73. Kolattukudy, Pappachan E. “Polyesters in Higher Plants.” Biopolyesters, 2001, pp. 1–49, doi:10.1007/3-540-40021-4_1; https://pubmed.ncbi.nlm.nih.gov/11217409/
    74. PubChem. “Dodecanedioic Acid.” pubchem.ncbi.nlm.nih.gov; https://pubchem.ncbi.nlm.nih.gov/compound/12736
    75. Tadashi Masamune, et al. Glycinoeclepins, Natural Hatching Stimuli for the Soybean Cyst Nematode,Heterodera Glycines. II. Structural Elucidation. Vol. 60, no. 3, 1 Mar. 1987, pp. 1001–1014, https://doi.org/10.1246/bcsj.60.1001; https://www.journal.csj.jp/doi/10.1246/bcsj.60.1001
    76. Mingrone, Geltrude, et al. “Use of Dicarboxylic Acids in Type 2 Diabetes.” British Journal of Clinical Pharmacology, vol. 75, no. 3, 5 Feb. 2013, pp. 671–676, doi:10.1111/j.1365-2125.2012.04177.x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575934/
    77. Greco, A. “The Metabolic Effect of Dodecanedioic Acid Infusion in Non–Insulin-Dependent Diabetic Patients.” Nutrition, vol. 14, no. 4, Apr. 1998, pp. 351–357, doi:10.1016/s0899-9007(97)00502-9; https://pubmed.ncbi.nlm.nih.gov/9591306/
    78. Salinari, Serenella, et al. “Dodecanedioic Acid Overcomes Metabolic Inflexibility in Type 2 Diabetic Subjects.” American Journal of Physiology. Endocrinology and Metabolism, vol. 291, no. 5, 1 Nov. 2006, pp. E1051-1058, doi:10.1152/ajpendo.00631.2005; https://journals.physiology.org/doi/full/10.1152/ajpendo.00631.2005
    79. Yan, Fengyao, et al. “Serum Metabolites Associated with Blood Pressure in Chronic Kidney Disease Patients.” Metabolites, vol. 12, no. 4, 23 Mar. 2022, p. 281, doi:10.3390/metabo12040281; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9027690/
    80. Mori, Shinobu et al. “Enhancement of lipolytic responsiveness of adipocytes by novel plant extract in rat.” Experimental biology and medicine (Maywood, N.J.) vol. 234,12 (2009): 1445-9. doi:10.3181/0904-RM-123 https://journals.sagepub.com/doi/10.3181/0904-RM-123
    81. ‌Martínez-Pinilla E. et al. Feb. 2015. “The Relevance of Theobromine for the Beneficial Effects of Cocoa Consumption. Frontiers in Pharmacology vol. 6,30; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335269/
    82. Khazan, M. March 2014. “Identification and Determination of Synthetic Pharmaceuticals as Adulterants in Eight Common Herbal Weight Loss Supplements.” Iranian Red Crescent Medical Journal vol. 16,3; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005444/
    83. Yoneda, Mitsugu, et al. “Theobromine Up-Regulates Cerebral Brain-Derived Neurotrophic Factor and Facilitates Motor Learning in Mice.” The Journal of Nutritional Biochemistry, vol. 39, Jan. 2017, pp. 110–116, 10.1016/j.jnutbio.2016.10.002; https://pubmed.ncbi.nlm.nih.gov/27833051/
    84. Wang, Zhuoran, et al. “Cyclic AMP Mimics the Anti-Ageing Effects of Calorie Restriction by Up-Regulating Sirtuin.” Scientific Reports, vol. 5, no. 1, 8 July 2015, 10.1038/srep12012; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648391/
    85. Nehlig, Astrid. “The neuroprotective effects of cocoa flavanol and its influence on cognitive performance.” British journal of clinical pharmacology vol. 75,3 (2013): 716-27. doi:10.1111/j.1365-2125.2012.04378.x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575938/
    86. Tanaka, Emi et al. “Theobromine enhances the conversion of white adipocytes into beige adipocytes in a PPARγ activation-dependent manner.” The Journal of nutritional biochemistry vol. 100 (2022): 108898. doi:10.1016/j.jnutbio.2021.108898 https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(21)00318-1
    87. Iwami, Momoe et al. “Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats.” Autonomic neuroscience : basic & clinical vol. 161,1-2 (2011): 63-7. doi:10.1016/j.autneu.2010.11.012 https://www.autonomicneuroscience.com/article/S1566-0702(10)00277-8/fulltext
    88. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-whole-body-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D/core-reader
    89. Sugita J, Yoneshiro T, et al; “Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27; https://www.jstage.jst.go.jp/article/jnsv/60/1/60_22/_pdf
    90. Rosenwald M, Wolfrum C; “The origin and definition of brite versus white and classical brown adipocytes”; Adipocyte; 2014;3(1):4-9; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917931/
    91. Kim SH, Plutzky J; “Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders”; Diabetes & Metabolism Journal. 2016;40(1):12-21; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768046/
    92. Sugita J, Yoneshiro T, et al; “Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27; https://pubmed.ncbi.nlm.nih.gov/24759256/
    93. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-whole-body-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D/core-reader
    94. Lafontan, M., et al. “Alpha-2 Adrenoceptors in Lipolysis: Alpha 2 Antagonists and Lipid-Mobilizing Strategies.” The American Journal of Clinical Nutrition, vol. 55, no. 1 Suppl, 1 Jan. 1992, pp. 219S227S, 10.1093/ajcn/55.1.219s; https://pubmed.ncbi.nlm.nih.gov/1345885/
    95. Callahan, Michael F., et al. “Yohimbine and Rauwolscine Reduce Food Intake of Genetically Obese (Obob) and Lean Mice.” Pharmacology Biochemistry and Behavior, vol. 20, no. 4, Apr. 1984, pp. 591–599, 10.1016/0091-3057(84)90309-5; https://pubmed.ncbi.nlm.nih.gov/6145164/
    96. Mizuki, Y., et al. “Differential Effects of Noradrenergic Drugs on Anxiety and Arousal in Healthy Volunteers with High and Low Anxiety.” Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 20, no. 8, 1 Nov. 1996, pp. 1353–1367, 10.1016/s0278-5846(96)00131-5; https://pubmed.ncbi.nlm.nih.gov/9004342/
    97. Perry BD, U’Prichard DC; European Journal of Pharmacology; “(3H)rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors;”1981; https://www.ncbi.nlm.nih.gov/pubmed/6276200
    98. Ostojic SM. Research in Sports Medicine;.”Yohimbine: the effects on body composition and exercise performance in soccer players.” 2006 Oct-Dec;14(4):289-99; https://pubmed.ncbi.nlm.nih.gov/17214405/
    99. Bhardwaj, R. et al. Aug. 2002. “Piperine, A Major Constituent of Black Pepper, Inhibits Human P-glycoprotein and CYP3A4.” The Journal of Pharmacology and Experimental Therapeutics vol. 302, 2. 645-50; https://pubmed.ncbi.nlm.nih.gov/12130727/
    100. Maeda A, Shirao T, Shirasaya D, Yoshioka Y, Yamashita Y, Akagawa M, Ashida H. Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Mol Nutr Food Res. 2018 Jun;62(11):e1800086. doi: 10.1002/mnfr.201800086; https://pubmed.ncbi.nlm.nih.gov/29683271/
    101. Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chem. 2013 Dec 15;141(4):3627-35. doi: 10.1016/j.foodchem.2013.06.028; https://pubmed.ncbi.nlm.nih.gov/23993530/
    102. Mittal R, Gupta RL. In vitro antioxidant activity of piperine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):271-4. doi: 10.1358/mf.2000.22.5.796644; https://pubmed.ncbi.nlm.nih.gov/11031726/
    103. Majeed, M, et al; “Use of piperine to increase the bioavailability of nutritional compounds”; United States Patent US5536506A; 24-Feb 1995; https://patents.google.com/patent/US5536506A/en
    104. Majeed, M, et al; “Use of piperine as a bioavailability enhancer”; United States Patent US5744161A; 30-Oct 1995; https://patents.google.com/patent/US5744161A/en
    105. Majeed, M, et al; “Use of piperine as a bioavailability enhancer”; United States Patent US5972382A; 12-Jan 1998; https://patents.google.com/patent/US5972382A/en
    106. Majeed, M; “Process for making high purity piperine for nutritional use”; United States Patent US6054585A; 23-Dec 1998; https://patents.google.com/patent/US6054585A/en

    Comments and Discussion (Powered by the PricePlow Forum)