Gains in Bulk NO MATTER WHAT: Pre-Workout Powered by enfinity® Paraxanthine

Gains in Bulk NO MATTER WHAT pre-workout swaps caffeine for enfinity® paraxanthine -- delivering clean energy that works regardless of your caffeine genetics. 300mg paraxanthine + 6g citrulline + transparent dosing = afternoon workouts without sleep issues.

The pre-workout category has been dominated by the same caffeinated formulas for years: high-stim blends that leave you jittery, crashed, and questioning whether that late-afternoon workout was worth the sleepless night ahead. Gains in Bulk is changing that narrative with their revolutionary NO MATTER WHAT™ pre-workout, powered by TSI Group's breakthrough enfinity® paraxanthine.

This isn't just another caffeine-loaded pre-workout with a flashy label. NO MATTER WHAT™ delivers what the industry has sorely needed: clean, sustained energy without the crash, enhanced focus that doesn't turn into anxiety, and performance benefits that work consistently across different metabolizer types. With 300mg of enfinity® paraxanthine leading a transparent, naturally-sweetened formula, this pre-workout is designed to perform when it matters most.

Clean Energy That Works NO MATTER WHAT Your Caffeine Genetics

While 93% of American adults consume caffeinated beverages daily, roughly 50% are considered slow caffeine metabolizers who don't experience optimal benefits from traditional caffeine consumption. That's where enfinity® paraxanthine changes everything, delivering the energy and focus you want without the genetic lottery that determines your caffeine response.

From the same innovative team behind TSI Group's OptiClear technology featured in Gains SHAPE, enfinity® provides a more refined alternative that works consistently across different metabolizer types, making NO MATTER WHAT™ the perfect pre-workout for anyone who's felt let down by traditional stimulants.

Before diving into the formula, sign up for PricePlow's Gains in Bulk news alerts and check current pricing below, then let's get into the science:

NO MATTER WHAT Ingredients

Each serving of NO MATTER WHAT™ provides a transparent, clinically-dosed formula designed for sustained energy, enhanced focus, and superior pumps:

• L-Citrulline (Vegan Fermented) - 6000mg

  The 6g dose of L-citrulline in NO MATTER WHAT starts things off with one of the most effective pump-enhancing ingredients. Traditional nitric oxide boosters relied on L-arginine, but citrulline provides a more efficient pathway to elevate plasma arginine levels and support enhanced blood flow during training.

  Superior nitric oxide pathway

  Oral L-citrulline supplementation raises plasma L-arginine concentration more effectively than L-arginine itself, due to citrulline's resistance to breakdown by intestinal enzymes.^[1] Once absorbed, citrulline converts to arginine in the kidneys through the citrulline-NO cycle, providing substrate for nitric oxide synthase enzymes to produce the nitric oxide that drives vasodilation and enhanced muscle blood flow.

  Performance and pump benefits

  Research demonstrates that L-citrulline supplementation improves exercise performance through multiple mechanisms. Studies show that citrulline can enhance high-intensity exercise performance while improving oxygen uptake kinetics -- the speed at which your muscles can utilize oxygen during the critical transition from rest to exercise.^[2] The large 6g dose in NO MATTER WHAT aligns with research showing that higher doses of citrulline (6-8g) are most effective for enhancing exercise capacity and the muscle pumps that athletes seek from their pre-workout.

  Beyond the immediate training benefits, L-citrulline may support faster recovery between sets by facilitating better nutrient delivery and waste product removal through improved blood flow to working muscles.^[3,4] This enhanced circulation helps maintain performance throughout longer training sessions while contributing to the satisfying muscle pump that signals effective training stimulus.

• Beta-Alanine - 3200mg

  

  Beta-alanine is one of the most researched endurance-boosting ingredients in sports nutrition, and NO MATTER WHAT delivers a full clinical dose. This non-essential amino acid doesn't directly fuel your muscles, but supports them indirectly, as it acts as the rate-limiting precursor to carnosine synthesis, creating one of your body's most important intracellular pH buffers.^[5]

  The carnosine connection

  When you supplement with beta-alanine, you're essentially loading your muscle fibers with increased carnosine concentrations. Research shows that four weeks of supplementation at 4-6g daily can boost muscle carnosine levels by up to 64%.^[5] This matters because carnosine serves as your muscles' internal buffer system, helping maintain optimal pH levels when lactic acid starts building up during intense exercise.

  Performance benefits where it counts

  The 3200mg dose in NO MATTER WHAT™ hits the sweet spot for performance enhancement. Meta-analysis research demonstrates that beta-alanine supplementation significantly improves exercise performance, with the most pronounced effects occurring during high-intensity efforts lasting 1-4 minutes.^[6] This makes it perfect for those final reps, extended sets, or any training that pushes you into that burn zone where lesser pre-workouts fall short.

  The dose here may bring a tingling sensation (paresthesia) that some experience with beta-alanine, but this is a harmless and non-toxic sensation that lets users know that it's time to get training. By delivering 3.2g as part of your pre-workout routine rather than requiring multiple daily doses, NO MATTER WHAT™ provides convenience while maintaining effectiveness for building those carnosine stores over time.

• Alpha-GPC (Alpha-Glyceryl Phosphoryl Choline) - 300mg

  

  Alpha-GPC is a potent cognitive enhancer that works through increasing acetylcholine levels in the brain, making it the perfect complement to enfinity® paraxanthine's clean energy profile. As a choline-containing phospholipid that can cross the blood-brain barrier, Alpha-GPC provides the raw materials for acetylcholine synthesis -- the neurotransmitter responsible for focus, memory, and the mind-muscle connection that drives performance.

  Research has shown that Alpha-GPC supplementation can enhance cognitive performance in healthy individuals, with a 200mg dose (less than we have here) demonstrating processing speeds that were 18% faster than caffeine and 11% faster than placebo on mental performance tasks.^[7] The 300mg dose in NO MATTER WHAT exceeds this effective range, providing support for enhanced mental clarity and focus during training while potentially supporting the neuromuscular efficiency that translates to better force production.

  What sets Alpha-GPC apart from other choline sources is its superior bioavailability and its dual-action benefits. While it sharpens mental focus for better training intensity, it simultaneously supports the acetylcholine pathways at the neuromuscular junction, which is the critical communication point between your nervous system and muscles. This creates a synergistic effect where enhanced cognitive function directly translates to improved physical performance, making every rep more focused and every set more productive.^[8]

  And now for the star of the show:

• Paraxanthine (as enfinity®) - 300mg

  

  Enfinity® paraxanthine represents the evolutionary leap beyond traditional caffeine supplementation. Although a vast majority of American adults rely on caffeine daily, roughly 50% are slow metabolizers who experience suboptimal benefits from standard caffeine consumption.^[9] NO MATTER WHAT's 300mg dose of enfinity® delivers the energy and focus benefits you want while eliminating the genetic variability that makes caffeine unreliable for many users.

  The caffeine metabolism problem

  When you consume caffeine, roughly 84% converts to paraxanthine, with the remainder forming theobromine (~12%) and theophylline (~4%).^[9] The problem lies with these latter metabolites -- they have significantly longer half-lives: 6.2 hours for theobromine and 7.2 hours for theophylline compared to paraxanthine's 3.1 hours.^[9]

  Even worse, theophylline is known to cause diarrhea, nausea, and irregular heartbeat -- it's literally a prescription bronchodilator with toxic doses as low as 7.5mg/kg.^[10] By taking pure paraxanthine, you sidestep the conversion to these problematic metabolites entirely.

  Enhanced cognitive and physical performance

  Recent research demonstrates that paraxanthine can in fact deliver superior benefits compared to caffeine. In a 2024 study examining cognitive function after a 10km run, paraxanthine supplementation improved reaction times and reduced cognitive errors more effectively than caffeine.^[11] The study found that post-exercise reaction times were 23.2% faster with paraxanthine compared to placebo and showed reduced perseverative errors on cognitive tests.

  

  Paraxanthine is the primary metabolite of caffeine, providing most of caffeine's beneficial effects. Now you can take it directly with enfinity!

  Beyond cognitive benefits, paraxanthine demonstrates impressive physical performance effects. Animal research shows paraxanthine supplementation increased forelimb grip strength by 17%, treadmill exercise performance by 39%, and muscle mass in key muscle groups by 14-41%.^[12]

  Unique mechanisms of action

  Enfinity® paraxanthine also works through multiple pathways that caffeine cannot access. Like caffeine, it functions as an adenosine receptor antagonist, but with higher binding potency for both A1 and A2A receptors.^[11] More importantly, paraxanthine inhibits phosphodiesterase 9 (PDE9), which terminates nitric oxide neurotransmission -- an effect that caffeine doesn't produce.^[11]

  This PDE9 inhibition potentiates nitric oxide pathways, supporting enhanced blood flow and potentially explaining why preclinical research shows paraxanthine can increase nitric oxide levels by 100% compared to control.^[12] The result is potentially improved blood flow to working muscles during exercise while supporting enhanced cognitive function.

  Metabolic and body composition benefits

  Recent human research also reveals that paraxanthine provides significant metabolic advantages. A dose-response study found that paraxanthine increased energy expenditure by approximately 100 calories over three hours while simultaneously reducing appetite and hunger sensations.^[13] Unlike caffeine, these effects occurred without increases in blood pressure or negative cardiovascular impacts.

  

  Cleaner energy profile

  The 300mg enfinity® dose in NO MATTER WHAT™ provides sustained energy without the typical caffeine drawbacks. Paraxanthine has less bitterness than caffeine, making it easier to formulate with better taste profiles. More importantly, its shorter half-life and faster clearance mean you can train later in the day without compromising sleep quality.

  This makes NO MATTER WHAT™ ideal for afternoon and evening workouts where traditional caffeine would interfere with recovery sleep. The consistent effects across different metabolizer types mean everyone gets the same reliable energy and focus benefits, making this truly a pre-workout that works NO MATTER WHAT™ your caffeine genetics.

  For comprehensive information about paraxanthine research and mechanisms, see our detailed guide: Paraxanthine: Caffeine's Major Metabolite for Laser-Targeted Energy.

• L-Theanine - 250mg

  L-Theanine provides the perfect complement to enfinity® paraxanthine, delivering calm focus without compromising energy or performance. This naturally occurring amino acid, found primarily in tea leaves, works through multiple mechanisms to enhance the pre-workout experience while mitigating potential stimulant-related side effects.

  L-Theanine's primary mechanism involves increasing gamma-aminobutyric acid (GABA) production in the brain, promoting relaxation and reducing stress without sedation.^[14] The amino acid also modulates other key neurotransmitters including serotonin and dopamine, contributing to improved mood and focus during training sessions.

  

  The 250mg dose in NO MATTER WHAT is clinically validated and works synergistically with paraxanthine. Research demonstrates that L-theanine enhances the cognitive benefits of stimulants while reducing unwanted effects like jitters or anxiety.^[15] When combined with stimulants, L-theanine improves attention accuracy, reaction time, and working memory while simultaneously reducing headache ratings and mental fatigue.

  This combination creates what's known as "calm energy" -- the alertness and focus you want from your pre-workout without the overstimulation that can interfere with mind-muscle connection and training quality. For NO MATTER WHAT users, this translates to sustained concentration throughout your entire workout, whether you're hitting PRs or grinding through high-volume training sessions.

• Organic Pink Himalayan Salt - 200mg

  Organic Pink Himalayan Salt provides 78mg of sodium per serving, delivering essential electrolyte support for optimal training performance. During intense exercise, your body loses sodium through sweat at rates that can significantly impact performance, muscle function, and hydration status.^[16]

  This moderate sodium dose helps maintain proper fluid balance without the excessive intake that can lead to bloating or discomfort during training. Adding sodium to pre-workouts supports enhanced water retention in muscles, improved nutrient delivery, and maintenance of normal muscle contraction mechanisms that can be compromised during extended training sessions.

  

  Unlike regular table salt, Pink Himalayan salt contains trace minerals that complement the formula's natural approach. At 78mg sodium (3% Daily Value), this dose provides meaningful electrolyte support without requiring additional supplementation for most training sessions, making NO MATTER WHAT a complete pre-workout solution that addresses both energy and hydration needs.

Flavors Available: Flavoring Powered by Sensapure Flavors!

Below is a list of flavors the PricePlow system has seen:

Note that this is a 100% naturally flavored and naturally sweetened flavor system developed in partnership with Sensapure Flavors. There are zero artificial colors or dyes.

How to Use NO MATTER WHAT

Mix one scoop (14.7g) with 8-12 oz of cold water 15-30 minutes before your workout. The naturally flavored and sweetened formula mixes cleanly without artificial colors or dyes, providing a smooth drinking experience that won't leave residue in your shaker.

Timing Considerations

Thanks to enfinity® paraxanthine's superior half-life profile compared to caffeine, NO MATTER WHAT™ is ideal for:

• Morning workouts - Clean energy without the crash
• Afternoon training - No interference with evening sleep, where paraxanthine shines

Stacking with Gains SHAPE

For those following comprehensive fitness goals, NO MATTER WHAT™ pairs perfectly with Gains in Bulk's SHAPE supplement. If training in the morning, you can use both like so:

Pre-Workout Strategy:

• Take NO MATTER WHAT 15-30 minutes before training
• The 300mg enfinity® dose provides sustained energy and focus
• 6g L-citrulline and beta-alanine support performance and endurance

Post-Workout Recovery:

• Use SHAPE post-workout or on non-training days
• The 200mg enfinity® dose in SHAPE supports metabolism without overstimulation
• Creatine and L-carnitine in SHAPE complement your training adaptations

Synergistic Benefits:

• Both products feature enfinity® paraxanthine for consistent energy
• NO MATTER WHAT fuels your workouts; SHAPE supports recovery and body composition
• Natural flavoring and transparent labeling across both formulas

SHAPE can still be taken any time on rest days, too.

This combination provides comprehensive support for training, recovery, and body composition goals while maintaining the clean energy philosophy that sets Gains in Bulk apart.

Conclusion: Pre-Workout Evolution Powered by Science

NO MATTER WHAT™ is a rethinking of what pre-workout supplementation should be. By centering the formula around enfinity® paraxanthine instead of traditional caffeine, Gains in Bulk has created a product that delivers consistent results regardless of your genetic caffeine metabolism.

The transparent, naturally-sweetened formula addresses real problems that athletes and fitness enthusiasts face: energy that works when you need it, focus without anxiety, and performance benefits that don't come with a crash tax. With clinical doses of proven ingredients like 6g L-citrulline, 3.2g beta-alanine, and 300mg Alpha-GPC, every component serves a purpose in driving better workouts.

For anyone who's been disappointed by traditional pre-workouts, whether due to jitters, crashes, or simply inconsistent effects, NO MATTER WHAT™ offers a science-backed alternative that puts performance first. Combined with its synergistic partnership with SHAPE for comprehensive fitness support, Gains in Bulk is building an ecosystem of supplements that work as hard as you do.