InnoSlim: Protect Your (Metabolic) Health

Toward the end of 2019, we took a deep dive into InnoSlim, a patented ingredient formulated by NuLiv Science. This blend of Astragalus membranaceus and Panax notoginseng was created to target metabolic functioning, improve the body’s ability to manage blood glucose levels, and improve insulin sensitivity. Such capabilities make the ingredient an excellent addition to fat-burning formulas, glucose disposal agents, and other weight-focused supplements.

Nuliv Science InnoSlim

More than ever, we understand metabolism and its critical importance. Besides exercise and cleaning up your diet from processed foods, how else can we accelerate our path back to metabolic wellness? Nuliv Science’s InnoSlim is one such accelerant.

We’ve decided to revisit InnoSlim and its effects, with additional context on why its capabilities are so relevant. While metabolic health is incredibly important due to the relationships it shares with multiple systems in the body, maintaining metabolic functioning is more important than it appears on the surface. Not only is it a challenge to keep a healthy metabolism these days, but the issues related to metabolic dysfunction are perhaps just as prevalent.

The stimulant-free metabolic accelerant

Leveraging the metabolic-boosting benefits of InnoSlim provides a unique avenue toward improved health and bodily function. To us, InnoSlim is a metabolic accelerant: Alongside a healthy diet low in processed foods, it allows you to operate at your best, both inside and outside the gym.

In this post, we’re going to provide a refresh on the mechanisms at work behind InnoSlim and\ discuss why they’re so important in the bigger picture.

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A Refresher: How InnoSlim Works

NuLivScience is a global research company with several patented ingredients including AstraGin, Astrion, and Senactiv on top of InnoSlim

InnoSlim is NuLiv Science’s patented blend of Astragalus membranaceus and Panax notoginseng, two herbs with roots in Ayurvedic medicine that have become particularly useful in sports supplements. If these herbs look familiar, you can also thank NuLiv for that — their popular absorption-boosting ingredient, AstraGin, is derived from the same two plants!

Despite these similarities in composition, InnoSlim and AstraGin differ in how they’re formulated. The scientists at NuLiv Science have crafted this ingredient to specifically target metabolic pathways in order to support metabolic health and weight-loss efforts. The clinical data shown below speaks to InnoSlim’s ability to affect multiple mechanisms related to metabolic functioning. Before we get there, however, we need to understand what these systems actually do.

The Metabolic Factors in Play

Metabolism is defined as “the whole sum of reactions that occur throughout the body within each cell and that provide the body with energy”.[1] This energy enables the body to do a variety of things — move, generate new tissues, develop, etc. The rate at which the metabolism runs (how fast and efficiently it burns calories) is largely dictated by factors such as sex, age, activity levels, and diet.[1] However, these factors don’t necessarily control “metabolism”, but rather the numerous enzymes, proteins, and cofactors that regulate it. These components include:

  • Adiponectin is a protein that boosts fatty acid oxidation and improves blood glucose levels and insulin response.[2] Adiponectin levels are higher in individuals with less adipose tissue. In other words, the leaner one is, the higher their adiponectin levels and effectiveness generally are.[2]
  • AMP-activated protein kinase (AMPK) is a protein kinase that facilitates energy balance by regulating the adenosine monophosphate (AMP) to adenosine triphosphate (ATP) ratio.[3] Energy-demanding states, such as those generated by exercise, activate AMPK to produce ATP.[3] AMPK stimulation thus induces metabolic activity, leading to increased fatty acid oxidation and glucose uptake.[3]
  • GLUT4 and SGLT1 are two transporter proteins that move glucose in the body. GLUT4 is expressed mainly in skeletal muscle and adipose tissue, where it regulates glucose uptake.[4] SGLT1, on the other hand, is a sodium-dependent transporter that works in the digestive tract to move sugars. Excessive SGLT1 expression can spike blood sugar levels, while SGLT1 inhibition can improve glycemic control and insulin response.[5]
  • Acetyl coenzyme A carboxylase phosphorylation (ACC-P) is a primary limiting factor of fatty acid synthesis. ACC regulates fatty acid production in the body and is effectively turned off by phosphorylation.[6] Upregulating ACC-P, then, can keep the body from forming and storing fatty acids.[6]
  • InnoSlim Fact Sheet

    Images on this page provided courtesy NuLiv Science. This is the first page of their “Fact Sheet”

    Hypoxia-inducible factor-1 (HIF-1) is a transcription factor central to the body’s ability to maintain homeostasis, particularly in low-oxygen scenarios (hypoxia).[7] HIF-1 is integral in the metabolic process, though its wide-reaching effects are both complex and very context-dependent.[8,9] However, research has found that the inhibition of HIF-1 expression in the hypothalamus (part of the brain responsible for homeostasis) can lead to obesity-associated issues, such as reductions in glucose uptake, increased hunger and cravings, and adiposity.[8] However, increased HIF-1 expression in endothelial cells can help regulate glucose uptake and appetite.[8]

  • Plasminogen activator inhibitor-1 (PAI-1) inhibits plasma fibrinolytic activity, an action that can lead to the development of cardiovascular complications such as atherothrombosis.[10,11] Produced in and released by adipose tissue, this protein is positively related to multiple markers of metabolic dysfunction, including total fat mass, visceral fat mass, inflammation, and insulin resistance.[10,12]
  • Retinol binding protein 4 (RBP4) is a retinol-carrying adipokine that sees heightened activity in the presence of obesity and diabetes.[13] It’s considered a biomarker of these conditions and their related symptoms, like insulin resistance, inflammation, suppressed immune response, and other conditions.[13]
  • Tumor necrosis factor-⍺ (TNF-⍺) is a cytokine that regulates various biological processes, including immune function and energy balance.[14] Mainly expressed in adipose tissue, TNF-⍺ is a key marker of inflammation, as well as insulin resistance and metabolic dysfunction.[15]

While this isn’t an exhaustive list of the body’s metabolic process, these components play vital roles in regulating proper digestion and energy conversion and expenditure. These factors also happen to present ways that InnoSlim promotes metabolic health.

The Research

Despite being a relatively novel ingredient, InnoSlim has 18 in vitro, two in vivo, and one human clinical study supporting its effectiveness in optimizing metabolic function.

  • Improves insulin sensitivity and blood glucose levels

    Though InnoSlim has a few different actions, perhaps its most exciting pertains to insulin response and glucose absorption. The body moves glucose into cells primarily through two transporters — SGLT1 for intestinal glucose absorption, and GLUT4 for muscle and fat cells.

    Reduces SGLT1 activity

    InnoSlim Intestinal Glucose

    Research shows that InnoSlim causes the small intestine to absorb less glucose into the bloodstream,[16] helping prevent more glycemic issues in the first place

    The first opportunity for glucose to enter the bloodstream is in the digestive tract. And while we ultimately want glucose to reach cells and fuel them, we don’t want this to happen too fast. High elevations in blood glucose levels after meals can increase the risk of diabetes.[17] This makes intestinal SGLT1, which are the body’s first-available glucose transporters, extremely important. Delaying glucose absorption through SGLT1 inhibition can maintain regular blood sugar levels, keeping diabetic complications and symptoms of metabolic syndrome at bay.

    In a 2007 in vitro study published in the Journal of Agricultural and Food Chemistry, researchers tested the effects of InnoSlim on glucose uptake in human Caco-2 cells. They treated cellular systems with multiple concentrations of the ingredient (0.01 micrograms per milliliter (mcg/ml), 0.10mcg/ml, and 1.00mcg/ml), comparing the rate of glucose transport in each model with a control group.[16] Using the 0.10mcg/ml as the primary measuring model, they found that InnoSlim reduced Caco-2 glucose absorption by 42%.[16] Diving deeper, the researchers found that the ingredient accomplishes this by inhibiting SGLT1 mRNA protein expression, with the 0.10mcg/ml concentration downregulating transporter activity by 25%. They also observed a dose-dependent effect, too — higher concentrations yielded larger reductions in absorption and SGLT1 activity.[16]

    InnoSlim effectively slows down the release of sugar into the bloodstream, preventing massive spikes in blood sugar levels and promoting a steady, stable glucose release that the body can better handle.

    Increases GLUT4 activity

    InnoSlim Mechanism of Action

    The full InnoSlimⓇ Mechanism of Action in one image

    Once sugars do enter the bloodstream, GLUT4 is primarily responsible for moving them into muscle and fat cells. In an ideal world, the majority of these sugars go toward building muscle, though simply having them removed from the blood is advantageous. In contrast to intestinal absorption, we want this transport to happen quickly so that we can avoid prolonged high levels of glucose in the blood.

    InnoSlim is capable of facilitating such a rapid response. In a 2008 study published in the Journal of Endocrinology, scientists treated both 3T3-L1 adipocytes and C2C12 myotubes with various doses of InnoSlim and assessed their rate of glucose uptake. They found that InnoSlim increased glucose uptake by 142% and 43% in fat and muscle cells, respectively.[18] These gains in absorption were facilitated by an increase in GLUT4 protein expression in both types of cells.[18]

    Despite showing more potency when operating on fat cells in this study, InnoSlim still boosted the sensitivity of both cell variants to glucose absorption. Applied in a situation where muscle cells need glucose — such as for individuals engaged in exercise — this effect can have massive implications for recovery and growth. In terms of general metabolic health, however, the reduction of blood sugar levels is beneficial in and of itself!

  • Inhibits glycogenesis and lipogenesis

    In a study published in a 2013 edition of Adaptive Medicine, a team of researchers studied the metabolic adaptation of human liver cells that had been treated with InnoSlim. At multiple concentrations, they found that the ingredient suppressed glycogen and lipid synthesis in a dose-dependent manner.[19]

    InnoSlim Insulin

    The impacts of chronically elevated insulin cannot be understated. While we’re all for spiking insulin around muscle-building operations, it’s important to keep it low in order to “re-enable” fat oxidation.

    The liver is central to regulating the metabolic response to glucose; so important that liver dysfunction — which results in abnormal glucose production, glucose uptake, glycogen production, and lipogenesis — is a key factor in insulin resistance and type 2 diabetes.[19] These findings further convey InnoSlim’s potency in improving metabolic health and insulin response.

  • Upregulates AMPK, ACC-P, and Adiponectin

    Though the blood glucose-optimizing effects cited so far may seem independent of one another, they aren’t. InnoSlim affects a few different mechanisms that modulate the improved insulin sensitivity, optimal glucose transport, and liver health we’ve discussed.

    In the previously-mentioned 2013 Adaptive Medicine study, the team dove deeper into the metabolic regulatory effects they were seeing. They found that across varying doses of InnoSlim, AMPK stimulation increased by as much as 200%, causing a downstream rise in ACC-P activity, too.[19] This stimulation bodes well for metabolic health — as this study was concerned specifically with liver cells, such increases in AMPK and ACC-P can increase fatty acid oxidation while suppressing hepatic glycogenesis and lipogenesis.[19]

  • Gene Expression

    InnoSlim Adiponectin

    Sustained weight loss is more than just caloric control. Hormones such as adiponectin play a major role in fatty acid oxidation, and can be supported through proper diet and supplementation.

    InnoSlim also acts on adiponectin gene expression. In a 2015 study published in Pharmaceutical Biology, C2C12 muscle cells treated with the ingredient saw increases in adiponectin receptor expression, in addition to increases in GLUT4 translocation.[20] These effects have been seen in fat cells, too. A 2015 analysis of obese mice, published in the Journal of Ginseng Research, found that InnoSlim can increase adiponectin expression in adipocytes, while simultaneously decreasing TNF-⍺ levels.[21] Given that adiponectin levels not only regulate food intake, energy expenditure, and body weight, but also suppress lipogenesis and increase fatty acid oxidation,[2,22] this modulation is extremely helpful in either gaining or maintaining metabolic health.

    In addition to all of this, further research shows that InnoSlim reduces cytokine activity in fat cells, suppressing inflammatory agents such as PAI-1, RBP4, and TNF-⍺.[23] The ingredient also modulates HIF-1 expression in muscle cells in such a way that promotes optimal metabolic function.[23]

    By acting upon these different (yet linked) biological mechanisms, InnoSlim creates a chain of effects that yields improved insulin response and metabolic functioning.

The Clinical Data

InnoSlim AMPK Muscle Cells

The glucose that does make it through the intestines has a better chance of going where we want it to go – into the muscle cells![24]

Seeing such promise in vitro and in animal studies, NuLiv Science funded a study testing InnoSlim’s potency in humans. In this double-blind, placebo-controlled procedure, volunteers were split into two groups. One group received InnoSlim (at an undisclosed dosage) while the other received a placebo. The volunteers were instructed to maintain their normal eating patterns. Post-treatment, multiple metabolic factors were assessed. The study authors found that the test group saw results consistent with the in vitro and in vivo research:

  • Roughly 30% increases in adiponectin expression, compared to placebo, leading to increases in AMPK, GLUT4, ACC-P, and energy expenditure
  • Reductions in adipocyte inflammation, in conjunction with increased glucose uptake in muscle and fat cells
  • 6% decreases in blood triglyceride levels, compared to placebo
  • Significant reductions in both body weight and body fat percentage.[23]

By incorporating InnoSlim into their daily diet, these individuals were able to induce more fatty acid breakdown, glucose uptake, and energy expenditure. In other words, they significantly improved the efficiency of their metabolism.

Dosing

InnoSlim Logo

Research shows users can experience reduced glucose absorption in the intestine, increased glucose absorption in muscle and fat cells, reduced fat accumulation and inflammation in fat cells, and reduce insulin resistance. With our ongoing metabolic crisis, this is the right ingredient for the right time.

Because of InnoSlim’s relevant novelty and the fact that many of the studies that have tested its effects in vitro or in animals, there’s no official clinical dosage yet. However, NuLiv Science recommends a daily dose of 250 milligrams. This is the same dose typically seen in products containing the potent glucose level-optimizer, some of which we’ll discuss soon!

Fights Metabolic Syndrome, and Much More

Based on the clinical data supporting it, InnoSlim is often thought of as a metabolic-boosting ingredient. As we’ve seen, that’s a fair assessment. The ingredient modulates various metabolic mechanisms in order to increase caloric expenditure, improve insulin sensitivity, optimize blood glucose levels, and promote a healthy body weight. However, to think of InnoSlim solely through this lens discredits its other potential applications.

Metabolic Dysfunction — A Widespread Issue

Waist Circumference Insulin Resistance

You can consider insulin resistance to mean “sugar saturation” – at some point, overfilled adipocytes refuse to store more energy. Waist-to-Height ratio makes for an excellent proxy to insulin resistance. Image courtesy Dr. Ted Naiman.

Metabolic syndrome is an amalgamation of multiple disorders, including but not limited to: hypertension, obesity, insulin resistance, atherogenic dyslipidemia (high blood triglycerides combined with imbalanced cholesterol levels), and inflammation.[25] Many of these complications arise when one of the mechanisms we’ve discussed falls out of sync. But, as we’ve seen, the components of the metabolism are linked — the proper functioning of one mechanism encourages efficient operations of another, and vice versa. Thus markers of metabolic syndrome are often tied to one another. For example: poor dietary choices lead to weight gain, which itself reduces insulin sensitivity. This negative feedback loop makes metabolic dysfunction quite dangerous, as its symptoms compound one another!

The development of these issues is a somewhat common problem, too. The standard Western diet — a diet high in sugar, processed/refined foods, and unhealthy industrial fats — is positively related to symptoms of metabolic syndrome.[26] The ubiquity of this dietary pattern and the food choices that exist in it is alarming, which is why we’ve seen such an importance placed on improving our health in recent years. And though we are seeing improvements — the portion of adults in the United States with metabolic syndrome have decreased from 34% to roughly 23% in the past decade[26] — metabolic dysfunction is still a serious danger.

Issues Related to Metabolic Syndrome

Exacerbating the problem, the negative effects of an inefficient metabolism mirror the effects of the metabolism itself. Metabolic syndrome increases the risk of developing cardiovascular disease,[25] diabetes,[25] neurological and cognitive disease,[27] and a suppressed immune system.[28] So not only does poor metabolic function further encourage other metabolic issues, but also additional health complications.

Thus, improving things like glucose levels, insulin sensitivity, and body composition can help defend the body from serious health complications, including those that attack the immune system.

Improving Our Health Through the Metabolism

InnoSlim PricePlow

Since InnoSlim is non-stimulatory, the doors are opened to a multitude of incredible weight loss applications.

Of course, there are ways to fight off and improve symptoms of metabolic dysfunction, such as making healthy, nutritious dietary choices and exercising.[25] And based on the clinical data supporting it, adding InnoSlim to a daily regimen that already incorporates these things can further support overall health.

It can be easy to get narrow-minded when thinking about nutrition and metabolism. And despite some of these views being valid — such as the link between poor metabolic health and weight gain, for instance — there’s much more at stake. Our ability to live healthier and longer, move better, think clearer, and feel better are all on the line, too. Optimizing metabolic health in conjunction with smart lifestyle choices goes a long way.

While InnoSlim fights symptoms of metabolic syndrome, it also does more. Metabolic complications have wide-reaching effects, putting quite a burden on both physical and mental health. By supporting the metabolism, we defend the health of our bodies in more ways than one.

Supplements with InnoSlim inside

Given its potent fat-burning, insulin sensitivity-boosting effects, InnoSlim is an extremely attractive ingredient for weight-management products. Its non-stimulatory nature makes it even more versatile, too, capable of being added into formulas that already contain caffeine and other energy-boosters without compounding their stimulatory effects. Thus, InnoSlim can fit neatly into fat-burners (both stimulant-based and stimulant-free), glucose disposal agents (GDAs), carnitine supplements, and other products.

Here are some of our favorite products that are putting InnoSlim to use:

  • Glaxon Thermal Graphic

    If your goal is fat loss, Glaxon Thermal is a great addition to your supplement stack – it’s stimulant-free and powered by InnoSlim!

    Glaxon Thermal: non-stimulant weight management aid from our 2020 Breakout Supplement Brand. This product is part of their season two stream of launches, where the brand is reformulating and improving some of their awesome products. In Thermal, InnoSlim works alongside other ingredients to activate fatty acid oxidation and increase energy expenditure.

  • Primeval Labs Pyretic: a stimulant-free fat burner that supports metabolic health and appetite suppression. One of three patented ingredients in this Primeval formula, InnoSlim is an excellent inclusion to serve the product’s dual focus.
  • Alpha Lion Cheetah Burn Non-Stim: a comprehensive, multifaceted caffeine-free fat burner. Alpha Lion packs Cheetah Burn Non-Stim with five ingredient complexes, each used for a specific purpose. Though InnoSlim finds itself in the Appetite Suppressant Matrix in this product, it surely contributes on other fronts, as well.
  • Like A Pro Burn Away: an energy and focus-based fat burner that approaches fat-burning on multiple fronts. Alongside a few stimulants that provide energy, focus, and fatty acid oxidation, InnoSlim is leveraged mainly for its glucose-regulatory capabilities.
  • NuLiv Science – InnoSlim: NuLiv Science also sells a small number of their products as single-ingredient supplements for formulators and innovative supplement users to test. This provides a quick option for consumers who simply want this blood glucose-optimizing weight-loss aid. As such, buying this is versatile and easily stackable with formulas lacking the potent ingredient.

Of course, this list isn’t all-inclusive — because of its capabilities, it’s likely you’ll find InnoSlim in other formulas, too. These just happen to be a few products that we think are pretty awesome.

InnoSlim: More Than a Metabolic-Booster

Fat burners and weight-loss aids receive quite a lot of attention in sports supplements as consumers search for the best ways to support healthy body weight and body composition. And let’s face it, whether you’re a professional bodybuilder looking to lean out for a competition or a weekend warrior that wants to get in better shape, many of us have tried dropping a few pounds of body fat at some point.

NuLiv Science InnoSlim

Our original InnoSlim article covers these topics in even greater detail!

But such goals are often only looked at through this one lens. A healthier body weight, balanced body composition, and optimal metabolic health have comprehensive effects that extend past “shape” — these things put us in a better position to fight inflammation, optimize immune function, and support longevity. In other words, weight management lends itself more to overall health than it might seem.

Optimizing our diet and training regimen are two of the best ways to pursue these endeavors and improve our health. Once these are taken care of, we can then look into other areas for additional gains — sleep hygiene, stress management, and of course, metabolic health. InnoSlim from NuLiv Science looks at the latter, activating mechanisms in the body to improve glucose uptake and blood sugar levels, increase energy expenditure, regulate appetite, and support weight management.

InnoSlim’s capabilities make it an excellent ingredient to include in a weight-focused regimen, yet its relevance doesn’t stop there. Influencing the metabolism on multiple fronts allows it to support our overall health, too. This makes NuLiv Science’s InnoSlim a powerful ingredient, one that we hope to see in various formulas across sports supplements.

Further reading can be found in our original InnoSlim article, and you can also see our NuLiv Science news page to stay up-to-date on all things NuLiv.

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References

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  23. NuLiv Science. “InnoSlim Overview”. https://nulivscience.com/ingredients/innoslim
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About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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