PLT Health Solutions has published new findings from their latest TestFACTOR clinical trial, demonstrating that their novel testosterone-boosting ingredient delivers far more than just physical performance benefits — it significantly enhances sexual health and overall quality of life in middle-aged men.
New TestFACTOR study drops serious results! 325mg daily significantly improved sexual function, testosterone levels, energy, and grip strength in healthy men 40-65. Benefits started at just 2 weeks across ALL domains of sexual health.
The study, published as an abstract in Current Developments in Nutrition, shows that just 325mg daily of TestFACTOR led to significant improvements in overall sexual function alongside substantial increases in both total and free testosterone levels.[1]
This research expands TestFACTOR’s tested benefits beyond the strength and endurance gains documented in previous trials, positioning it as a comprehensive solution for the interconnected challenges of male aging. As we detailed in our original TestFACTOR ingredient analysis, this botanical blend has now demonstrated efficacy across four randomized controlled trials, with this latest study specifically targeting sexual wellness and longevity markers.
As a quick refresher, TestFACTOR is PLT Health’s patented 2:1 blend of standardized extracts from Sphaeranthus indicus (East Indian Globe Thistle) flower heads and Mangifera indica (Mango Tree) bark. These two botanicals have rich histories in Ayurvedic medicine for supporting male vitality and longevity.
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A Targeted Sexual Health and Vitality Study
This 8-week randomized, double-blind, placebo-controlled trial recruited 60 healthy, recreationally active men aged 40-65 with BMI of 22-29.9 kg/m² and testosterone levels above 300 ng/dL. Participants were randomly allocated to receive either 325mg TestFACTOR or placebo daily.
PLT Health Solutions introduces TestFACTOR, a testosterone-boosting ingredient featuring Mangifera indica and Sphaeranthus indicus. Backed by clinical studies, it enhances testosterone, vitality, and sexual health in middle-aged men, with benefits like improved energy, strength, and quality of life.
The researchers assessed multiple outcome measures at baseline and on days 7, 14, 28, and 56, including:
- Serum total and free testosterone
- Handgrip strength
- Changes in Sexual Function Questionnaire (CSFQ-14)
- Perceived energy levels, stress, and sleep quality via validated scales
- Body composition (DEXA)
- Additional hormones including DHT, cortisol, and estradiol
What Makes This Study Unique
Unlike previous TestFACTOR research that focused primarily on strength and athletic performance, this study specifically targeted sexual wellness and longevity markers in middle-aged men. The researchers used validated questionnaires including the Changes in Sexual Function Questionnaire (CSFQ-14), alongside comprehensive biomarker analysis and physical assessments.
Testosterone Results: Rapid and Sustained Increases
The hormonal benefits appeared quickly and continued growing throughout the study period, consistent with TestFACTOR’s established testosterone-supporting effects:
Total and Free Testosterone Improvements
- Significant increases in total testosterone on days 14, 28, and 56 compared to placebo
- Significant increases in free testosterone on days 28 and 56 compared to placebo
- Improvements in testosterone:estradiol and free testosterone:cortisol ratios compared to placebo
These results show that TestFACTOR can enhance testosterone levels in healthy middle-aged men who already had healthy baseline levels, with benefits appearing as early as 2 weeks for total testosterone and 4 weeks for free testosterone.
Sexual Function: Improvements Across All Domains
The sexual health results are impressive, with TestFACTOR demonstrating significant improvements in every measured aspect of sexual function:
Overall Sexual Function Score
- Significant improvements in total CSFQ score on days 14, 28, and 56 compared to placebo
- Benefits appeared as early as 2 weeks and continued throughout the study
Domain-Specific Improvements (all by week 8):
- Pleasure/Satisfaction: Significant improvement
- Sexual Frequency: Significant improvement
- Interest/Desire: Significant improvement
- Arousal/Erections: Significant improvement
- Orgasm/Ejaculation: Significant improvement
These improvements demonstrate that TestFACTOR addresses sexual health from multiple angles, supporting not just physiological function but also psychological aspects like desire and satisfaction.
Energy, Sleep, and Quality of Life Benefits
Beyond sexual health, TestFACTOR demonstrated serious effects on energy levels and fatigue, benefits that align perfectly with its testosterone-boosting properties:
Energy and Fatigue
- Significant improvements in energy levels as measured by the Chalder Fatigue Scale
- Benefits vs. placebo by day 56
Sleep Quality and Stress
- Improved sleep quality (Athens Insomnia Scale)
- Reduced perceived stress (Perceived Stress Scale)
- Both improvements significant vs. placebo by day 56
These quality of life improvements align with TestFACTOR’s testosterone-supporting properties and suggest broader benefits for male vitality and well-being.
Physical Performance: Grip Strength as a Longevity Marker
TestFACTOR Significantly Improved
Total and Free Testosterone
The study also measured handgrip strength—a well-established marker of overall health and longevity:
Grip Strength Results
- Significant improvements vs. placebo on days 28 and 56
- Time × treatment interaction significant (p < 0.001)
Grip strength improvements are clinically meaningful as research has linked grip strength to reduced risk of cardiovascular events, all-cause mortality, and overall health outcomes. This demonstrates TestFACTOR’s benefits extend beyond sexual health to markers of physical vitality and longevity.
Body Composition and Additional Benefits
TestFACTOR also showed positive effects on body composition:
Body Composition Changes
- Decreased body fat compared to baseline values
- Increased lean body mass compared to baseline values
- Improvements occurred by day 56
These changes support TestFACTOR’s role in optimizing male physiology through multiple pathways beyond just testosterone support.
Safety Profile and Tolerability
The study demonstrated TestFACTOR’s excellent safety profile:
- No significant changes in DHT levels in either group
- Improved hormone ratios rather than concerning elevations
- Well-tolerated throughout the 8-week study period
The lack of DHT elevation is noteworthy, as it suggests TestFACTOR supports healthy testosterone optimization without unwanted increases in this more potent and controversial androgen.
Timeline of Benefits: Rapid Onset Across Multiple Domains
Based on the study’s timeline, TestFACTOR benefits appeared progressively:
- Week 1: Initial assessments conducted
- Week 2: Total testosterone improvements vs. placebo; sexual function improvements begin
- Week 4: Free testosterone and grip strength improvements vs. placebo
- Week 8: Peak benefits across all measured domains
This relatively rapid onset makes TestFACTOR appealing for consumers seeking noticeable improvements within the first month of supplementation.
The Science Behind TestFACTOR’s Multi-Modal Benefits
TestFACTOR Significantly Improved Sexual
Function Across Numerous Domains
As detailed in our TestFACTOR ingredient overview, TestFACTOR’s benefits stem from multiple mechanisms of action involving its two botanical components:
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East Indian Globe Thistle (Sphaeranthus indicus) flower
The flower heads contain bioactive compounds including sphaeranthanolide and 7-Hydroxy frullanolide (7HF), which contribute to the extract’s testosterone-supporting and anti-inflammatory properties.
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Mango Tree (Mangifera indica) bark
Rich in mangiferin and other polyphenolic compounds, the bark extract supports mitochondrial function, muscle protein synthesis, and antioxidant activity.
Together, these extracts create a synergistic effect that goes beyond simple testosterone support, addressing multiple pathways involved in male vitality, sexual health, and longevity—as demonstrated across TestFACTOR’s four completed clinical trials.
Implications for Men’s Health and Sports Nutrition
This research positions TestFACTOR as a well-rounded solution for the interconnected challenges of aging in men: declining testosterone, reduced sexual function, decreased energy, and loss of physical strength. The fact that a single botanical ingredient can address all these areas simultaneously represents a significant advancement in natural men’s health support.
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For the Active Nutrition Market
The study’s focus on men with already-healthy testosterone levels (>300 ng/dL) is noteworthy for the sports nutrition market, as it demonstrates TestFACTOR’s ability to optimize hormone levels and performance even in men who aren’t clinically deficient. The grip strength improvements and energy benefits make it relevant for active individuals seeking all-around male health support.
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Beyond Basic Testosterone Support
Unlike single-pathway testosterone boosters, TestFACTOR’s multi-modal approach addresses the complex interplay between hormones, energy, sexual function, and overall vitality. This positions it well for premium men’s health formulations targeting the growing market of health-conscious middle-aged men.
Conclusion: TestFACTOR Sets New Standards for Natural Male Enhancement
PLT Health Solutions: Growth Through Innovation
This latest TestFACTOR study demonstrates the ingredient’s ability to address the interconnected aspects of male health — sexual function, testosterone levels, energy, and physical vitality. The comprehensive nature of these benefits, combined with rapid onset and excellent safety profile, positions TestFACTOR as a leading option for natural male health support.
For formulators and consumers alike, this research reinforces that effective natural male enhancement requires well-researched, clinically validated ingredients used in appropriate doses. As we detailed in our original TestFACTOR analysis, PLT Health Solutions continues to set the standard for evidence-based botanical ingredients.
This sexual health and vitality study adds another layer of clinical validation to TestFACTOR’s growing research portfolio, establishing it as a powerful, research-backed solution for men seeking natural optimization of their health and performance.
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