The aXivite Explosion: 4 New Products Showcase Phenylcapsaicin's Fat Loss Potential

After years of development, aXivite phenylcapsaicin has finally arrived in the supplement industry with impressive force. On top of multiple introductory launches from MuscleTech, four new products have launched recently, each taking a unique approach to harnessing this innovative thermogenic ingredient's fat loss benefits. From simple standalone formulas to comprehensive multi-ingredient blends, these supplements show the versatility and growing acceptance of SEE Nutrition's breakthrough capsaicin analog.

aXivite Supplements Continue to Evolve: Performance and Body Composition

aXivite is a significant advancement over traditional capsaicin, offering enhanced bioavailability and reduced pungency while maintaining the metabolic benefits that make capsaicin a valuable thermogenic compound. Recent research shows phenylcapsaicin can increase fat oxidation during exercise while reducing perceived exertion,^[1-3] making it an attractive option for both athletes and dieters.

While additional performance research from SEE Nutrition awaits journal publication, the current fat loss data has been powerful enough to drive this wave of product launches. In this article, we discuss each product, from the simplest standalone formulation to the most comprehensive multi-ingredient blends.

Before we dig in to each one, sign up for PricePlow's aXivite news alerts so that you get notified during new launches and research study publications:

Now for the new supplements, but first, note that aXivite is microencapsulated, supplying 1% phenylcapsaicin. This will make sense when we get to the research doses below.

The Pure Approach: Carotec’s aXivite

For those seeking the most straightforward introduction to phenylcapsaicin, Carotec's aXivite offers the purest approach with 120mg of phenylcapsaicin blend per capsule. This standalone supplement provides the highest per-serving dose among current offerings, making it ideal for users who want to experience aXivite's effects without additional ingredients.

Key Features:

• 120mg phenylcapsaicin blend per capsule
• Plant-based capsules for a 30 or 60 day supply
• No additional active ingredients
• Flexible dosing: 1-2 capsules for weight management, 2-4 capsules for sports performance

Carotec positions their product for both weight management and exercise performance, recommending taking capsules before meals for metabolic benefits or 45 minutes before exercise for performance enhancement. The clean, simple formula appeals to users who prefer single-ingredient supplements or want to stack aXivite with their existing regimen.

See this product at Carotec.com.

The Synergistic Blend: Silver Fern Brand’s Metabolism

Silver Fern Brand's Metabolism takes a targeted two-ingredient approach, combining 120mg aXivite with 1,100mg berberine.. This pairing creates synergistic effects for metabolic health and body composition.

Key Features:

• 120mg aXivite for thermogenesis and appetite control
• 1,100mg Berbevis (Berberine Phytosome)
• Twice-daily dosing with meals
• Focus on body composition rather than rapid weight loss

The combination leverages berberine's well-established effects on insulin sensitivity and glucose metabolism alongside aXivite's thermogenic properties. Silver Fern Brand emphasizes that Metabolism supports healthy body composition changes over 4-6 months rather than quick weight loss, positioning it as a sustainable approach to metabolic health.

Berbevis uses Phytosome delivery technology for superior absorption compared to standard berberine, while aXivite serves as both a thermogenic agent and bioenhancer. The formula aims to increase calorie burning, improve fat oxidation, and support appetite control for long-term body composition improvements.

See this product at SilverFernBrand.com.

The AM Focus: Unmatched Supps’ 2SHRED AM

Unmatched Supps' 2SHRED system includes both AM and PM formulas, with only the AM formula containing aXivite. Inside, 2SHRED AM provides 100mg aXivite alongside several complementary thermogenic and metabolic ingredients for comprehensive daytime fat burning support.

Key Features:

• 100mg aXivite for performance and thermogenesis
• 500mg MitoBurn (L-BAIBA), an exercise mimetic for mitochondrial support
• 450mg Sinetrol XPur citrus extract for fat metabolism
• 250mg Coleus forskohlii extract (20% forskolin) for cAMP elevation
• 125mg InnoSlim for glucose utilization
• No artificial sweeteners, flavors, and colors in anything from Unmatched Supps

Brought to you by Kris Gethin and Doug Miller, the 2SHRED AM formula creates a comprehensive thermogenic matrix without stimulants, making it stackable with caffeine-containing pre-workouts or suitable for afternoon use. The inclusion of MitoBurn at clinical doses supports mitochondrial function and fat oxidation, while Sinetrol provides additional lipolytic effects.

The companion PM formula focuses on nighttime metabolism, hormonal balance, and appetite control without aXivite, creating a complete 24-hour fat loss system when used together.

You can read more about this in our article titled "Unmatched Supps 2SHRED AM & PM: Kris Gethin's 24-Hour Weight Management System".

The Comprehensive Formula: Zenos Health’s BurnZen

Coming soon, Zenos Health's BurnZen brings the most comprehensive approach, featuring 62.5mg aXivite within a 12-ingredient stimulant-free formula designed for complete metabolic optimization.

Key Features:

• 62.5mg aXivite (1% phenylcapsaicin) for thermogenesis
• 300mg GlucoVantage (dihydroberberine) for glucose metabolism
• 450mg Actiponin (Gynostemma pentaphyllum) for AMPK activation
• 300mg Curcumin (95% curcuminoids) for inflammation support
• 250mg MitoBurn for mitochondrial function
• 200mcg Chromax chromium picolinate for insulin sensitivity
• 500mg Ceylon Cinnamon Extract for metabolic health
• Plus green tea extract, saffron, grains of paradise, fucoxanthin, and probiotics

BurnZen takes a multi-pathway approach to fat loss, addressing thermogenesis, insulin sensitivity, inflammation, gut health, and appetite control simultaneously. The formula emphasizes metabolic optimization rather than stimulant-driven effects, making it suitable for long-term use without tolerance concerns.

The inclusion of postbiotic BPL1 HT adds gut health support, while the combination of berberine analog (GlucoVantage), AMPK activator (Actiponin), and thermogenic compounds creates multiple synergistic pathways for body composition improvements.

You can see this product at BurnZen.com

This rounds up the four new supplement launches, but if you're looking for more "gains" than just losses, or to have some stimulants involved, MuscleTech has the OG aXivite supplements:

The Proven Players: MuscleTech’s Alpha Test Lineup

MuscleTech pioneered commercial aXivite use with their Alpha Test Thermo and Alpha Test Thermo XTR products, both containing 62.5mg aXivite within hybrid testosterone-boosting and fat-burning formulations.

• Alpha Test Thermo

  Key Features:

  • 62.5mg aXivite for metabolic enhancement
  • 1g L-Carnitine L-Tartrate for fat oxidation and androgen receptor density
  • 225mg Caffeine for energy and thermogenesis
  • 600mg Fenugreek Extract for testosterone support
  • 20mg Grains of Paradise for brown adipose tissue activation

• Alpha Test Thermo XTR

  Key Features:

  • 62.5mg aXivite for thermogenic effects
  • 600mg KSM-66 Ashwagandha for stress management and testosterone
  • 200mg enfinity Paraxanthine instead of caffeine for cleaner energy
  • 1g L-Carnitine L-Tartrate for metabolic and androgenic effects
  • 40mg CaloriBurn Grains of Paradise for enhanced thermogenesis

Both MuscleTech formulas target male users seeking simultaneous fat loss and testosterone optimization. The XTR version offers advantages for afternoon training with its shorter-acting paraxanthine instead of caffeine, plus higher doses of key thermogenic ingredients and adaptogenic support from ashwagandha.

Choosing Your aXivite Approach

The range of these six products demonstrates aXivite's versatility across different supplement categories and user needs:

• For Simplicity: Carotec's standalone aXivite offers the purest experience with maximum dosing flexibility.
• For Targeted Metabolic Support: Silver Fern's Metabolism provides synergistic berberine pairing for comprehensive glucose and fat metabolism enhancement.
• For Complete Daytime Support: Unmatched's 2SHRED AM delivers comprehensive stimulant-free thermogenesis with complementary ingredients.
• For Total Metabolic Optimization: Zenos Health's BurnZen offers the most comprehensive multi-pathway approach to body composition improvement.
• For Male-Focused Hybrid Effects: MuscleTech's Alpha Test products combine fat burning with testosterone support in proven formulations.

So what is aXivite? Let's dive in a bit, but remember, you can always see the full story in our article, "aXivite Phenylcapsaicin: Performance-Enhancing Spice with Less Burn".

The Science Behind aXivite: A Breakthrough in Capsaicin Technology

aXivite is more than just another thermogenic ingredient hitting the market. These formulations are built on a foundation of breakthrough science in phenylcapsaicin that enhances traditional capsaicin while unlocking new possibilities for both metabolic enhancement and athletic performance.

Why Traditional Capsaicin Falls Short

Capsaicin, the compound responsible for chili peppers' characteristic burn, has long been recognized for its impressive health benefits. Research shows that capsaicin can boost metabolism and promote weight loss by increasing thermogenesis and reducing appetite.^[4] The compound also improves cardiovascular health by reducing LDL cholesterol, enhancing blood flow, and decreasing hypertension risk while providing anti-inflammatory and antioxidant effects.^[5]

However, traditional capsaicin has always faced a critical dosing problem. While studies show significant performance benefits, they often require doses of 12-24mg daily, which can cause gastrointestinal distress and make consistent supplementation challenging.^[6] There are a few good ways to get around this issue, and phenylcapsaicin is one of the most novel:

The aXivite Innovation: Phenylcapsaicin Engineering

aXivite phenylcapsaicin represents a fundamental advancement in capsaicin technology through two key innovations: chemical modification and microencapsulation.

• Chemical Enhancement Through Phenyl Group Addition

  At its core, aXivite involves binding a phenyl group (C6H5) to the capsaicin molecule, creating phenylcapsaicin. This seemingly simple modification produces dramatic improvements in bioavailability and stability. According to aXichem's internal research, this phenyl group binding increases bioavailability by approximately 800% compared to standard capsaicin, meaning the same effects can be achieved at roughly one-eighth the dose.

  

  The HD aXivite treatment condition (marked by the green triangle) caused a significant reduction in perceived heat after the maximal exercise test. PRE=before exercise, POST 1=after submaximal test but before incremental test, POST 2=after incremental test.^[2]

  The European Food Safety Authority conducted extensive safety evaluations on phenylcapsaicin, including detailed ADME (absorption, distribution, metabolism, and excretion) studies comparing it directly to capsaicin. Their research showed that phenylcapsaicin has superior pharmacokinetic properties, with better tissue distribution and more efficient metabolism.^[7]

• Microencapsulation for Tolerability

  The second innovation involves aXichem's proprietary microencapsulation process, which coats the phenylcapsaicin molecules to protect users from the characteristic burning sensation and potential gastrointestinal irritation. This encapsulation technology allows for comfortable daily use at effective doses, removing the primary barrier that has limited capsaicin supplementation.

TRPV1 Receptor Activation: The Master Mechanism

Both traditional capsaicin and aXivite phenylcapsaicin work primarily through activation of the Transient Receptor Potential Vanilloid 1 (TRPV1) receptor.^[8] This mechanism underlies virtually all of capsaicin's beneficial effects, from thermogenesis to performance enhancement.

Metabolic Effects Through TRPV1

TRPV1 activation triggers several metabolic pathways that contribute to fat loss and body composition improvements:

• Thermogenesis Enhancement: TRPV1 stimulation increases brown adipose tissue activity, promoting non-shivering thermogenesis that burns calories as heat rather than storing them as fat.^[9] This process can significantly increase daily energy expenditure without requiring additional physical activity.
• Appetite Regulation: TRPV1 activation influences satiety signaling, helping users feel fuller after meals and reducing overall caloric intake.^[10]
• Insulin Sensitivity: Capsaicin compounds improve glucose metabolism and insulin sensitivity, supporting better nutrient partitioning and reducing fat storage tendency.^[11]
• Lipid Metabolism: TRPV1 activation enhances fat oxidation during both rest and exercise while reducing lipid accumulation in tissues, especially the liver.

Through TRPV1 activation and other pathways from capsaicin-based compounds, we may additionally get anti-inflammatory effects, longevity benefits,^[12] digestive health improvements, mood and cognitive effects, and overall cardiovascular protection.

There's a lot to explore here, but performance enhancement has been the most interesting development:

Performance Enhancement Through Neural Modulation

The performance benefits observed in aXivite studies stem from TRPV1's effects on specific nerve fiber types. TRPV1 receptors are highly expressed in afferent type III and IV nerve fibers, which play crucial roles in exercise-induced fatigue.^[13]

When these nerve fibers detect metabolic stress during exercise, they send signals that contribute to both peripheral and central fatigue. TRPV1 activation through aXivite appears to modulate these signals by:

• Desensitizing pain and discomfort receptors
• Improving blood flow and metabolic efficiency
• Enhancing endorphin release
• Reducing perceived exertion during exercise

This neural modulation explains why aXivite studies consistently show reduced ratings of perceived exertion alongside improved performance metrics.

Clinical Research: Validating the Science

Three published randomized controlled trials have validated aXivite's effectiveness at doses far lower than those required for traditional capsaicin. First, note that these studies show the doses of pure phenylcapsaicin, so the 0.625mg dose corresponds to 62.5mg aXivite in the supplements listed above.

1. Resistance Training Performance Study

   In a triple-blind, placebo-controlled crossover trial, resistance-trained men performed squat exercises at 70% of their one-rep max after taking either 0.625mg or 2.5mg aXivite versus placebo.^[1]

   

   Key findings:

   • Improved lifting velocity throughout exercise sessions
   • Reduced muscle damage markers (AST levels)
   • Lower perceived exertion ratings (~15% reduction)
   • Enhanced recovery between training sessions

2. Aerobic Performance and Fat Oxidation Study

   A second study examined aXivite's effects on endurance performance and substrate utilization during steady-state aerobic exercise.^[2]

   Key findings:

   • Significantly increased fat oxidation during submaximal exercise
   • Reduced maximum heart rate during testing (improved cardiovascular efficiency)
   • Lower thermal perception (felt cooler during intense exercise)
   • Maintained performance with less physiological stress

3. Multi-Exercise Performance Study

   The third study used a comprehensive testing protocol including squats, isometric holds, and countermovement jumps to assess aXivite's effects across different movement patterns.^[3]

   Key findings:

   • Higher mean propulsive velocity during squats
   • Reduced velocity loss across exercise sets
   • Dramatically improved countermovement jump height post-exercise
   • Enhanced power output maintenance throughout testing

Dose-Response Relationships and Bioavailability

The research shows incredible dose-response patterns that highlight aXivite's potent bioavailability. The 2.5mg dose consistently outperformed the 0.625mg dose across studies, but even the lower dose often showed benefits compared to placebo. This suggests that effective aXivite doses begin well below 1mg, making the 62.5-120mg doses used in commercial products extremely conservative and likely highly effective.

To put this in perspective, studies showing ergogenic benefits from traditional capsaicin typically use 12-24mg doses. The fact that aXivite produces similar or superior effects at 2.5mg represents roughly an 8-10x improvement in potency, aligning perfectly with aXichem's bioavailability claims.

Safety Profile and Regulatory Approval

The European Food Safety Authority's comprehensive safety evaluation concluded that phenylcapsaicin is safe for proposed uses up to 2.5mg daily, with no concerns regarding genotoxicity or other adverse effects. This regulatory approval from one of the world's most stringent food safety authorities provides significant confidence in aXivite's safety profile.^[7]

The EFSA evaluation included detailed toxicology studies, pharmacokinetic analysis, and extensive comparison to traditional capsaicin, ultimately determining that phenylcapsaicin presents no unique safety concerns while offering superior bioavailability characteristics.

aXivite and the Impact of Innovation

With aXivite, SEE Nutrition in partnership with aXichem brought a serious breakthrough that removed the primary barriers limiting capsaicin supplementation. By achieving superior effects at dramatically lower doses while eliminating gastrointestinal side effects, aXivite makes the extensive benefits of TRPV1 activation accessible to a bigger population.

The four new products recently launched with aXivite show the industry's recognition of its potential. As more research emerges (especially additional sports performance studies), we expect to see even more applications that leverage aXivite's combination of metabolic enhancement and performance benefits.

In recent episodes of the PricePlow Podcast, we've talked about successful products that cross categories to make entirely new "hybrid categories". This is exactly what can be done with aXivite. From simple standalone supplements to comprehensive multi-ingredient formulas, it can get incorporated into many worlds. The research supports performance, the fat loss focus of these latest launches, and hints at much broader applications that may emerge as the ingredient gains wider recognition.

Looking Forward

With more research from SEE Nutrition expected to be published soon, we anticipate even more applications for aXivite beyond fat loss. The current product lineup demonstrates strong industry acceptance, with formulas ranging from 62.5mg to 120mg per serving across different product categories.

We're excited to see how creative brands choose to adopt aXivite, but the current offerings provide excellent starting points for anyone interested in experiencing the benefits of this next-generation capsaicin analog.

For those interested in learning more about aXivite's mechanisms and research, be sure to check out our main aXivite ingredient analysis and podcast with SEE Nutrition's Elias Chiatalas for deeper insights into this breakthrough ingredient's development and applications.