Pills vs. Powder: MuscleTech Burn iQ Fat Burners Re-Ignite The Age Old Question

Published on February 16, 2023 by Mike Roberto | No Comments

Last year brought us many incredible supplement innovations, but none greater than the enfinity-powered launch of MuscleTech’s iQ Series. This included three supplements — two for weight loss and one pre-workout — all powered by the smoother caffeine alternative called paraxanthine, trademarked as enfinity.

Along with a podcast featuring Raza Bashir, MuscleTech’s VP of Scientific Affairs and Product Innovation, we’ve covered each of these products in depth:

MuscleTech Burn iQ Pills vs Powder

It’s the age old question… pills or powder?! With MuscleTech Burn iQ, you have a tough choice to make – but it’s ultimately a win-win.

Today we’re going to focus on the bottom two — the thermogenic fat burners — both of which are available at GNC alongside MuscleTech’s site directly.

Why are there two Burn iQ Fat Burners? What are the Differences?

Dieters looking for some smart weight loss support have come to the right place – the enfinity in both Burn iQ products provides a smooth, feel-good effect that’s further supported by the nootropic and thermogenic ingredients in each product.

It’s not a question of whether you should try Burn iQ — everyone should experience the paraxanthine alternative to caffeine — the question is which to get: pills or powder?

Besides the obvious form factor differences, there are a couple key differentiators to discuss that will help you make the right decision for yourself. They’re covered below, but before we dig into the details, let’s compare prices and get you signed up for MuscleTech’s news alerts – they’ve got quite a big year planned:

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At the time of writing this, the coupon-based prices of the products are the same, so that shouldn’t weigh in on the decision. So let’s get more nuanced:

Pills vs. Powder in Fat Burners: The Main Differences

Setting aside the two products’ ingredient differences for a moment, let’s quickly cover the pros of each form factor:

MuscleTech Burn iQ Pills vs Powder

Pros of fat burning capsules

  • More convenient / easier to transport
  • No added ingredients like sweeteners, colors, flavor systems, and excipients
  • Slower ingredient release profile
  • One less shaker cup – can drink alongside your favorite non-caffeinated beverage

Pros of fat burning powders

  • Larger doses (this is discussed in detail in the next section)
  • Ability to precisely dose stimulants
  • Great taste and a more enjoyable experience

So if you find that you like exactly 250 milligrams of paraxanthine, you can make that happen pretty easily with the powder — but it’s not so convenient to take 2.5 capsules!

The spice effect of Burn iQ Powder

Taste will definitely play a major part here. While Burn iQ Powder tastes incredible, it does have some spice to it. There are three spices inside (aXivite phenylcapsaicin, grains of paradise extract, and black pepper extract) that undoubtedly add some zing to that Sweet Heat. It’s definitely not for everyone, and if you think you’d rather skip the spice, then capsules will be the way to go.

With that noted, let’s get into the specifics of the ingredients:

The active ingredient differences between Burn iQ versions

First, take a look at the two labels side-by-side:

MuscleTech Burn iQ Ingredients: Capsules vs. Powder

Side-by-side: Burn iQ Capsules (left), Powder (right)

When analyzing the differences, we’ll use the full doses of the products, which come from 3 capsules or 2 scoops of the powder (both yielding 300 milligrams of enfinity paraxanthine).

  • L-Carnitine: 2.4 grams more in the powder

    L-carnitine is an important weight loss ingredient because of its role in energy production — it transports fatty acids to the mitochondria of our cells, enabling ATP (energy) production.[1] It’s conditionally essential — our bodies can make it, but in times of stress (ie. dieting or training), we could almost always use more to perform optimally.

    L-Carnitine

    After reading a new review based upon 100 citations, we are finding fewer and fewer reasons not to take ~2g L-Carnitine each day[2]

    Carnitine works best for weight loss in those who are most deficient, namely vegans / vegetarians,[3-6] the elderly,[7,8] and hard-training athletes.[2]

    It’s a powerful ingredient — now let’s take a look at the types of L-carnitine used.

    • The capsules use 600 milligrams of n-acetyl L-carnitine hydrochloride, a form of acetyl l-carnitine (ALCAR) that’s quite useful in nootropic applications[9] since it can cross the blood-brain barrier.[10]
    • The powder uses 3 grams of L-carnitine L-tartrate, which works best in flavored applications, since the tartaric acid it’s bound to generally improves taste.[11]

    Most research is at 2 grams of carnitine per day

    More important than the differences in types are the sheer dosage differences. In general, athletic-centric research has shown that 2 grams per day is the most common clinically-tested dosage of carnitine.[2] Burn iQ Powder goes well above this dose — you’ll basically get 2 grams in a single heaping scoop!

    Additionally, a six-month study published in 2009 showed that 2 grams of carnitine per day led to improved blood sugar response and better insulin sensitivity,[12] indicating metabolic improvements.

    600 milligrams in capsules is still a significant amount

    MuscleTech enfinity Paraxanthine Explained

    MuscleTech’s Raza Bashir and Ingenious Ingredients (and NNB Nutrition CSO) Shawn Wells join the PricePlow Podcast for Episode #072 to talk about MuscleTech’s new iQ Series launch, using enfinity Paraxanthine!

    MuscleTech clearly takes carnitine seriously — the 600 milligrams they fit into three capsules actually takes up an entire capsule itself! And all is not lost — even though it’s not a 2 gram dose, it still should help boost the diet, since it’s more than most people eat in the first place.[13] And doses of under 600 milligrams have still had success in maintaining carnitine levels in humans[14] and have been shown to reduce signs of aging.[15]

    In humans, a study using 500 milligrams of acetyl L-carnitine showed a noticeable increase in serum carnitine levels, with the maximum level occurring 3.1 hours after ingestion,[16] but it is rather variable from person to person.[17]

    Animal models have also shown that even low doses of acetyl L-carnitine can prevent cognitive decline.[18]

    So do you need 2 grams per day? No, especially not if you’re eating red meat, which has a lot of carnitine. But is the 3 gram dose in Burn iQ Powder better for dieters? Certainly.

  • L-Tyrosine: Only in powder

    While care was taken to keep some carnitine in the capsules, this couldn’t be done for the next two ingredients – L-tyrosine and taurine.

    Thyroxine

    Long story short: No iodine or tyrosine, no thyroid hormone synthesis. Get enough iodine and tyrosine in!!

    Burn iQ Powder has 1.5 grams of L-Tyrosine in two scoops. This is an amino acid found in neural tissue that leads to dopamine and adrenaline production, supporting mood, focus, and stress resistance.[19] We love its nootropic properties,[20,21] which fits in well with this smart supplement series. Especially with its research supporting cognition in times of sleep deprivation.[22-24]

    MuscleTech Burn iQ Powder

    MuscleTech Burn iQ Powder is the first weight loss supplement to include the caffeine replacement known as paraxanthine (from enfinity) and an incredible assortment of thermogenics and metabolism boosters!

    However, what’s often understated is the connection between tyrosine and thyroid health. The thyroid is critical for both exercise performance[25] and recovery,[26] and hard training can sometimes interfere with the production of thyroid hormones.[27]

    However, tyrosine is a precursor to thyroid hormones – it’s needed to make both namely triiodothyronine (T3) and thyroxine (T4).[28] Animal studies have shown that tyrosine deficiency leads to poor thyroid hormone production,[29] so this is a great ingredient to have.

    Is it necessary to have? Generally no. But it’s certainly a nice ingredient — especially in times of poor sleep.

  • Taurine: Only in powder

    Another ingredient that generally requires scoop-sized doses is taurine, which is dosed at 1 gram in two scoops of Burn iQ Powder. Taurine is a sulfur-based ingredient with a plethora of health benefits, and while it’s also conditionally essential like carnitine, many researchers indeed call it essential.[30]

    In workout settings, we often talk about taurine’s ability to act as a hydrating osmolyte,[31] its incredible effects on endurance (even with a single use at this dose),[32] its role in muscle signaling,[33] its nootropic potential,[34,35] and its mitochondria-supporting antioxidant status.[36-38]

    Taurine Endurance

    Taurine’s effect on endurance, with success in doses anywhere from 1 gram to 6 grams.[32]

    But for weight loss applications, you should also know that taurine can increase the body’s BAT-to-WAT ratio[39] — the amount of metabolically-active brown adipose tissue as opposed to white adipose tissue that’s used for storage. In fact, while allowing new brown adipose tissues to form, taurine can prevent new white adipose tissue from growing![40,41]

    This is very useful, because brown adipose tissue burns through fatty acids and glucose by expending heat – the whole idea with Burn iQ!

    As for the dose in the powder, you get 1 gram in two scoops, which has been shown to be effective for endurance in a meta-analysis published in 2018.[32]

  • Green coffee bean extract: higher dose in the capsules

    Now it’s time for a few ingredients where the capsules take the edge.

    MuscleTech iQ Series Augmented Reality

    MuscleTech is using a high-tech Augmented Reality (AR) platform to educate consumers about their new enfinity-fueled iQ series!

    With MuscleTech’s, caffeine-free green coffee bean extract, you get well-documented anti-inflammatory, anti-obesity, anti-diabetic, and antioxidant properties[42] that can help the body metabolize both glucose and fatty acids[43] while inhibiting the creation of new adipose cells.[42]

    Good news for the capsules – rather than try to add insignificant doses of above ingredients like tyrosine and taurine, MuscleTech opted to put 600 milligrams in the capsules as opposed to the 400 milligrams in the powder!

  • aXivite phenylcapsaicin – higher dose in the capsules

    If you’re looking for heat, the capsules have twice the dose of aXivite phenylcapsaicin — 60 milligrams in 3 capsules versus 30 milligrams in two scoops of the powder.

    Phenylcapsaicin is a derivative of capsaicin, which you may know as the potent constituent of chili peppers. A phenyl group has been added to the molecule to stabilize it, leading to more consistent results — but according to research, it did not interfere with capsaicin’s action.[44]

    That research showed that low-dose phenylcapsaicin improved gut health while helping subjects lose more fat and waist circumference than placebo.[44]

    In the capsules, you get twice as much, for far more burn – but without having to taste it!

  • Grains of paradise – higher dose in the powder

    Back to the powder, the famed grains of paradise extract comes in 30 milligrams in three capsules, but 40 milligrams in two scoops of powder! A spice trade-off compared to the aXivite dosing, if you will.

    Grains of Paradise Energy Expenditure

    Energy expenditure change (ΔEE) after oral ingestion of Grains of Paradise.[46] This spice helps melt away those stubborn pounds!

    Grains of Paradise is an ancient spice known as Aframomum Melegueta that’s been clinically shown to increase energy expenditure and improve body composition. Its constituents — especially 6-paradol — increase caloric expenditure by burning extra calories and expending them as heat.

    There are two human clinical trials on grains of paradise, one at 40 milligrams (where significant metabolic rate improvements were seen within 30 minutes and lasted over 2 hours)[45] and the other at 30 milligrams (where women showed decreased abdominal visceral fat and burnt 100 more calories per day compared to placebo through 4 weeks).[46]

    The good news is that both products have at least one study to match – but for the capsules, you’ll need to get all three caps in to hit that 30 milligram dose.

  • Forskolin: Higher dose in the powder

    Additionally, the Burn iQ Powder has 50 milligrams more coleus extract (standardized for 10% forskolin) — 200 milligrams in two scoops compared to 150 milligrams in three capsules.

    This relative of mint has been shown to activate cAMP, boosting cellular energy and increasing the metabolic rate.[47] It’s able to suppress appetite[48,49] and can help improve body composition, lipid profile, and insulin sensitivity compared to placebo in users on caloric restriction.[50]

    MuscleTech Burn iQ Capsules

    The new year brings a new time to try a new fat burning supplement – and MuscleTech’s Burn iQ includes a new caffeine replacement in enfinity brand paraxanthine!

    Quite honestly, these are both sizable doses — we often just see 50 milligrams total.

  • Black pepper extract – not in the capsules

    Interestingly, we have black pepper extract in the powder, but not the capsules! A rather large (and unique) 10.5 milligram dose, standardized for 95% piperine, leaves us with just a hair under 10 milligrams of piperine.

    This is useful because piperine is an antioxidant[51] that can increase the bioavailability of other ingredients taken alongside it.[52] It works by inhibiting stomach enzymes that break down ingredients in the intestine,[53] which is sometimes too soon for the biological effects we desire.

    But there are also fat loss effects – it can increase GLUT4 expression, which allows muscle cells to take up more glucose from the bloodstream.[54] This can lead to improved insulin sensitivity and metabolic health.

    Further, piperine can assist in the removal of liver fat.[55] Finally, it can synergize with grains of paradise extract to boost energy expenditure through non-shivering thermogenesis.[56]

    Most brands just use black pepper extract as an ingredient absorption agent, but it’s obviously far more than that!

  • Huperzine A – higher dose in the capsules

    The capsules have triple the dose of huperzine A — 30 milligrams vs. 10 milligrams — which is an acetylcholinesterase inhibitor,[57] meaning it can interfere with the breakdown of acetylcholine. This ultimately means higher acetylcholine levels, which is helpful for learning, memory, and coordination.[58,59]

    This puts a bit more smart in this smart supplement series, as it can support mitochondria in the neurons[60] and even assist with new neuron growth![61]

  • More vitamins in the capsules

    Finally, it’s worth noting that the Burn iQ Capsules have a few more vitamins:

    MuscleTech Burn iQ Thermo

    • 0.9mg (75% DV) Thiamin in the capsules, none in the powder
    • 0.96mg (74% DV) Riboflavin in the capsules, none in the powder
    • 7.2mg (45% DV) Niacinamide in the capsules, none in the powder
    • 1.27mg (75% DV) Vitamin B6 in the capsules, 1.7mg (100% DV) in the powder
    • 7.2mcg (300% DV) Vitamin B12 in the capsules, 2.4mcg (100% DV) in the powder

    So as you can see, it’s not so cut and dry – and the powder doesn’t always have more. In general, it’s going to come down to preferred form factor and whether you like drinking a little bit of flavored spice.

Another thing to consider is your diet — if you eat a diet high in muscle meat, chances are you’re doing great on carnitine and taurine and don’t necessarily need the powder as much as a vegan, vegetarian, or low meat eater would.

One final consideration: the effects of inactive ingredients

Finally, one last comment on the powder that we leave for the bottom since it’s not really substantiated by hard science. In general, the more added inactive ingredients you ingest, the more work it forces the liver to do. We believe this may temporarily and ever-so-slightly reduce the metabolic organ’s ability to do other things, like metabolize food and burn liver fat.

For instance, the tiny amount of beta-carotene that’s used in Burn iQ Powder as a color agent is processed by the liver to form retinal and subsequently retinol,[62] or vitamin A — which is a fat soluble vitamin, after all.[63]

Splitting hairs? Absolutely. But something to consider – if you’re a “minimalist” kind of person, you may appreciate fewer inactive ingredients in the capsules.

All Variations for Sale:

If any new flavors are added, they’ll be listed below:

Burn iQ

The Smarter Way to Burn

      Conclusion: There’s no wrong decision with Burn iQ

      Ultimately, dieters are going to be pleased regardless – MuscleTech is the first supplement brand to use enfinity paraxanthine, and it’s the real deal. If you’re tired of the excessive effects of caffeine, but still want some stimulation, then this is where you can go.

      To learn more about it, and the products inside, listen to our podcast with MuscleTech’s Raza Bashir or read any of our three MuscleTech iQ Series articles:

      Good luck with your decision, and enjoy the smart shredding.

      MuscleTech – Deals and Price Drop Alerts

      Get Price Alerts

      No spam, no scams.

      Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

      Posts are sponsored in part by the retailers and/or brands listed on this page.

      About the Author: Mike Roberto

      Mike Roberto

      Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

      Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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      References

      1. Sahlin, K. “Boosting Fat Burning With Carnitine: An Old Friend Comes Out from the Shadow.” Journal of Physiology vol. 589,Pt 7 (2011): 1509-10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099008/
      2. Fielding, Roger et al. “l-Carnitine Supplementation in Recovery after Exercise.” Nutrients vol. 10,3 349. 13 Mar. 2018, doi:10.3390/nu10030349; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/
      3. Krajcovicová-Kudlácková, M., et al. “Correlation of Carnitine Levels to Methionine and Lysine Intake.” Physiological Research, vol. 49, no. 3, 2000, pp. 399–402; https://pubmed.ncbi.nlm.nih.gov/11043928/
      4. Lombard, K A, et al. “Carnitine Status of Lactoovovegetarians and Strict Vegetarian Adults and Children.” The American Journal of Clinical Nutrition, vol. 50, no. 2, 1 Aug. 1989, pp. 301–306, 10.1093/ajcn/50.2.301; https://academic.oup.com/ajcn/article-abstract/50/2/301/4651007
      5. Krajcovicová-Kudlácková, M., et al. “Correlation of Carnitine Levels to Methionine and Lysine Intake.” Physiological Research, vol. 49, no. 3, 2000, pp. 399–402; https://pubmed.ncbi.nlm.nih.gov/11043928/
      6. Rebouche, Charles J. “Carnitine Function and Requirements during the Life Cycle.” The FASEB Journal, vol. 6, no. 15, Dec. 1992, pp. 3379–3386, 10.1096/fasebj.6.15.1464372; https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.6.15.1464372
      7. Malaguarnera, Mariano, et al. “Serum Carnitine Levels in Centenarians.” Clinical Drug Investigation, vol. 17, no. 4, 1999, pp. 321–327, 10.2165/00044011-199917040-00008; https://link.springer.com/article/10.2165/00044011-199917040-00008
      8. Malaguarnera, Mariano, et al. “L-Carnitine Treatment Reduces Severity of Physical and Mental Fatigue and Increases Cognitive Functions in Centenarians: A Randomized and Controlled Clinical Trial.” The American Journal of Clinical Nutrition, vol. 86, no. 6, 1 Dec. 2007, pp. 1738–1744, 10.1093/ajcn/86.5.1738; https://pubmed.ncbi.nlm.nih.gov/18065594/
      9. Traina, Giovanna. Jun 1, 2016. “The Neurobiology of Acetyl-L-Carnitine.” Frontiers in Bioscience (Landmark Edition); U.S. National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/27100509
      10. Kido, Yasuto, et al. “Functional Relevance of Carnitine Transporter OCTN2 to Brain Distribution of L-Carnitine and Acetyl-l-Carnitine across the Blood-Brain Barrier.” Journal of Neurochemistry, vol. 79, no. 5, 7 July 2008, pp. 959–969, doi:10.1046/j.1471-4159.2001.00621.x; https://onlinelibrary.wiley.com/doi/full/10.1046/j.1471-4159.2001.00621.x
      11. Junge, Jonas Yde, et al. “Taste Interactions between Sweetness of Sucrose and Sourness of Citric and Tartaric Acid among Chinese and Danish Consumers.” Foods, vol. 9, no. 10, 9 Oct. 2020, p. 1425, doi:10.3390/foods9101425; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600934/
      12. Ruggenenti, Piero, et al. “Ameliorating Hypertension and Insulin Resistance in Subjects at Increased Cardiovascular Risk: Effects of Acetyl-L-Carnitine Therapy.” Hypertension (Dallas, Tex.: 1979), vol. 54, no. 3, 1 Sept. 2009, pp. 567–574, 10.1161/HYPERTENSIONAHA.109.132522. https://pubmed.ncbi.nlm.nih.gov/19620516/
      13. Rebouche, Charles J. “Kinetics, Pharmacokinetics, and Regulation of L-Carnitine and Acetyl-l-Carnitine Metabolism.” Annals of the New York Academy of Sciences, vol. 1033, no. 1, Nov. 2004, pp. 30–41, doi:10.1196/annals.1320.003; https://pubmed.ncbi.nlm.nih.gov/15591001/
      14. Keller, U, et al. “Carnitine Status of Pregnant Women: Effect of Carnitine Supplementation and Correlation between Iron Status and Plasma Carnitine Concentration.” European Journal of Clinical Nutrition, vol. 63, no. 9, 3 June 2009, pp. 1098–1105, doi:10.1038/ejcn.2009.36; https://pubmed.ncbi.nlm.nih.gov/19491916/
      15. Sharman, Edward H, et al. “Reversal of Biochemical and Behavioral Parameters of Brain Aging by Melatonin and Acetyl L-Carnitine.” Brain Research, vol. 957, no. 2, Dec. 2002, pp. 223–230, doi:10.1016/s0006-8993(02)03551-5; https://pubmed.ncbi.nlm.nih.gov/12445964/
      16. Kwon, Oh-Seung, and Youn Bok Chung. “HPLC Determination and Pharmacokinetics of Endogenous Acetyl-L-Carnitine (ALC) in Human Volunteers Orally Administered a Single Dose of ALC.” Archives of Pharmacal Research, vol. 27, no. 6, 1 June 2004, pp. 676–681, doi:10.1007/BF02980169; https://pubmed.ncbi.nlm.nih.gov/15283472/
      17. Cao, Yu, et al. “Comparison of Pharmacokinetics of L-Carnitine, Acetyl-L-Carnitine and Propionyl-Lcarnitine after Single Oral Administration of L-Carnitine in Healthy Volunteers.” Clinical & Investigative Medicine, vol. 32, no. 1, 1 Feb. 2009, p. 13, doi:10.25011/cim.v32i1.5082; https://pubmed.ncbi.nlm.nih.gov/19178874/
      18. Freddi, Roberta, et al. “Behaviour and Degenerative Changes in the Basal Forebrain Systems of Aged Rats (12 Months Old) after Levo-Acetyl-Carnitine Treatments.” Journal of Behavioral and Brain Science, vol. 2, no. 1, 29 Feb. 2012, pp. 18–25, doi:10.4236/jbbs.2012.21003; https://www.scirp.org/journal/PaperInformation.aspx?paperID=17717
      19. Attipoe, S. et al; Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature; Military Medicine; Volume 180, Issue 7, July 2015, Pages 754–765; https://academic.oup.com/milmed/article/180/7/754/4160625#101253256
      20. Colzato, Lorenza S et al. “Working memory reloaded: tyrosine repletes updating in the N-back task.” Frontiers in behavioral neuroscience vol. 7 200. 16 Dec. 2013, doi:10.3389/fnbeh.2013.00200 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863934/
      21. Steenbergen, Laura et al. “Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance.” Neuropsychologia vol. 69 (2015): 50-5. doi:10.1016/j.neuropsychologia.2015.01.022 https://pubmed.ncbi.nlm.nih.gov/25598314/
      22. Neri, D F et al. “The effects of tyrosine on cognitive performance during extended wakefulness.” Aviation, space, and environmental medicine vol. 66,4 (1995): 313-9. https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(15)00029-9
      23. Magill, Richard A, et al. “Effects of Tyrosine, Phentermine, Caffeine D-Amphetamine, and Placebo on Cognitive and Motor Performance Deficits during Sleep Deprivation.” Nutritional Neuroscience, vol. 6, no. 4, 2003, pp. 237–46, doi:10.1080/1028415031000120552; https://pubmed.ncbi.nlm.nih.gov/12887140/
      24. Deijen, J.B, and J.F Orlebeke. “Effect of Tyrosine on Cognitive Function and Blood Pressure under Stress.” Brain Research Bulletin, vol. 33, no. 3, Jan. 1994, pp. 319–323, doi:10.1016/0361-9230(94)90200-3; https://pubmed.ncbi.nlm.nih.gov/8293316/
      25. McAllister, R M et al. “Thyroid status and exercise tolerance. Cardiovascular and metabolic considerations.” Sports medicine (Auckland, N.Z.) vol. 20,3 (1995): 189-98. doi:10.2165/00007256-199520030-00005; https://link.springer.com/article/10.2165/00007256-199520030-00005
      26. Sunita et al. “Heart rate and blood pressure response to exercise and recovery in subclinical hypothyroid patients.” International journal of applied & basic medical research vol. 3,2 (2013): 106-10. doi:10.4103/2229-516X.117076; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783662/
      27. Ciloglu, Figen et al. “Exercise intensity and its effects on thyroid hormones.” Neuro endocrinology letters vol. 26,6 (2005): 830-4; https://pubmed.ncbi.nlm.nih.gov/16380698/
      28. National Center for Biotechnology Information. “PubChem Pathway Summary for Pathway SMP0000006, Tyrosine Metabolism, Source: PathBank” PubChem, https://pubchem.ncbi.nlm.nih.gov/pathway/PathBank:SMP0000006
      29. Khaliq, W et al. “Reductions in tyrosine levels are associated with thyroid hormone and catecholamine disturbances in sepsis.” Intensive Care Medicine Experimental vol. 3,Suppl 1 A686. 1 Oct. 2015, doi:10.1186/2197-425X-3-S1-A686 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4798095/
      30. Ripps, H. et al. Nov. 2012. “Review: Taurine: A “Very Essential Amino Acid.” Molecular Vision vol. 18. 2673-86; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501277/
      31. Pasantes-Morales, H., et al. “Taurine: An Osmolyte in Mammalian Tissues.” Advances in Experimental Medicine and Biology, 1998, pp. 209–217, 10.1007/978-1-4899-0117-0_27; https://link.springer.com/chapter/10.1007/978-1-4899-0117-0_27
      32. Waldron, M., et al. May 2018. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine vol. 48,5; 1247-53; https://pubmed.ncbi.nlm.nih.gov/29546641
      33. Spriet, Lawrence L, and Jamie Whitfield. “Taurine and skeletal muscle function.” Current opinion in clinical nutrition and metabolic care vol. 18,1 (2015): 96-101. doi:10.1097/MCO.0000000000000135; https://pubmed.ncbi.nlm.nih.gov/25415270/
      34. Chen, C. et al. Aug. 2019. “Roles of Taurine in Cognitive Function of Physiology, Pathologies, and Toxication.” Life Sciences vol. 15, 231; https://pubmed.ncbi.nlm.nih.gov/31220527/
      35. Wang, Ke, et al. “Taurine Improves Neuron Injuries and Cognitive Impairment in a Mouse Parkinson’s Disease Model through Inhibition of Microglial Activation.” NeuroToxicology, vol. 83, Mar. 2021, pp. 129–136, 10.1016/j.neuro.2021.01.002; https://www.sciencedirect.com/science/article/abs/pii/S0161813X21000085
      36. Ibrahim, Marwan A et al. “Therapeutic role of taurine as antioxidant in reducing hypertension risks in rats.” Heliyon vol. 6,1 e03209. 17 Jan. 2020, doi:10.1016/j.heliyon.2020.e03209; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970174/
      37. Jong, Chian Ju et al. “Mechanism underlying the antioxidant activity of taurine: prevention of mitochondrial oxidant production.” Amino acids vol. 42,6 (2012): 2223-32. doi:10.1007/s00726-011-0962-7; https://pubmed.ncbi.nlm.nih.gov/21691752/
      38. Jong, Chian Ju et al. “The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant.” Molecules (Basel, Switzerland) vol. 26,16 4913. 13 Aug. 2021, doi:10.3390/molecules26164913; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400259/
      39. Guo, Ying-Ying et al. “Taurine-mediated browning of white adipose tissue is involved in its anti-obesity effect in mice.” The Journal of biological chemistry vol. 294,41 (2019): 15014-15024. doi:10.1074/jbc.RA119.009936; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791308/
      40. Kim, Kyoung Soo et al. “Anti-obesity effect of taurine through inhibition of adipogenesis in white fat tissue but not in brown fat tissue in a high-fat diet-induced obese mouse model.” Amino acids vol. 51,2 (2019): 245-254. doi:10.1007/s00726-018-2659-7; https://dx.doi.org/10.1007/s00726-018-2659-7
      41. Lin, Shan et al. “Taurine improves obesity-induced inflammatory responses and modulates the unbalanced phenotype of adipose tissue macrophages.” Molecular nutrition & food research vol. 57,12 (2013): 2155-65. doi:10.1002/mnfr.201300150; https://onlinelibrary.wiley.com/doi/10.1002/mnfr.201300150
      42. Onakpoya, I. et al. 2011. “the Use of Green Coffee Extract as a Weight Loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials.”Gastroenterology Research and Practice vol. 2011: 382852; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943088/
      43. Flanagan, J. et al. 2014.”Lipolytic Activity of Svetol®, a Decaffeinated Green Coffee Bean Extract.”; Phytotherapy Research: PTR vol. 28,6 (2014): 946-8. https://pubmed.ncbi.nlm.nih.gov/24338784/
      44. Framroze, Zeenia, et al. “Placebo Controlled Study to Investigate the Relationship between Lowering Serum Zonulin Levels and Improved Body Weight Composition Using a Daily Oral Dose of Phenylcapsaicin.” International Journal of Clinical Skills, no. 7, 2022, pp. 258–264, https://www.ijocs.org/clinical-journal/placebo-controlled-study-to-investigate-the-relationship-between-lowering-serum-zonulin-levels-and-improved-body-weight-.pdf
      45. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-whole-body-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D/core-reader
      46. Sugita J, Yoneshiro T, et al; “Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans”; Journal of Nutritional Science and Vitaminology; 2014, 60(1): 22-27; https://www.jstage.jst.go.jp/article/jnsv/60/1/60_22/_pdf
      47. Litosch, I., et al. “Forskolin as an Activator of Cyclic AMP Accumulation and Lipolysis in Rat Adipocytes.” Molecular Pharmacology, vol. 22, no. 1, 1 July 1982, pp. 109–115. https://pubmed.ncbi.nlm.nih.gov/6289066/
      48. Henderson, Shonteh, et al. “Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women.” Journal of the International Society of Sports Nutrition, vol. 2, no. 2, Dec. 2005, 10.1186/1550-2783-2-2-54; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-2-2-54
      49. Han, Li-Kun, et al. “Effects of Coleus Forskohlii on Fat Storage in Ovariectomized Rats.” Yakugaku Zasshi, vol. 125, no. 5, 1 May 2005, pp. 449–453, 10.1248/yakushi.125.449; https://pubmed.ncbi.nlm.nih.gov/15863977/
      50. Loftus, Hayley, et al. “Coleus Forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial.” Nutrients, vol. 7, no. 11, 17 Nov. 2015, pp. 9508–9522, 10.3390/nu7115483; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663611/
      51. Mittal R, Gupta RL. In vitro antioxidant activity of piperine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):271-4. doi: 10.1358/mf.2000.22.5.796644; https://pubmed.ncbi.nlm.nih.gov/11031726/
      52. Kesarwani, Kritika et al. “Bioavailability enhancers of herbal origin: an overview.” Asian Pacific journal of tropical biomedicine vol. 3,4 (2013): 253-66. doi:10.1016/S2221-1691(13)60060-X; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634921/
      53. Cui, Tiantian et al. “Piperine Is a Mechanism-Based Inactivator of CYP3A.” Drug metabolism and disposition: the biological fate of chemicals vol. 48,2 (2020): 123-134. doi:10.1124/dmd.119.088955; http://dmd.aspetjournals.org/cgi/pmidlookup?view=long&pmid=31748224
      54. Carvalho, Eugenia, et al. “Adipose-Specific Overexpression of GLUT4 Reverses Insulin Resistance and Diabetes in Mice Lacking GLUT4 Selectively in Muscle.” American Journal of Physiology-Endocrinology and Metabolism, vol. 289, no. 4, Oct. 2005, pp. E551–E561, 10.1152/ajpendo.00116.2005; https://journals.physiology.org/doi/full/10.1152/ajpendo.00116.2005
      55. Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chem. 2013 Dec 15;141(4):3627-35. doi: 10.1016/j.foodchem.2013.06.028; https://pubmed.ncbi.nlm.nih.gov/23993530/
      56. ‌Kim, Nami, et al. “Piperine Regulates UCP1 through the AMPK Pathway by Generating Intracellular Lactate Production in Muscle Cells.” Scientific Reports, vol. 7, no. 1, 24 Jan. 2017, 10.1038/srep41066; https://www.nature.com/articles/srep41066
      57. Tang, X. C., et al. “Effect of Huperzine A, a New Cholinesterase Inhibitor, on the Central Cholinergic System of the Rat.” Journal of Neuroscience Research, vol. 24, no. 2, 1 Oct. 1989, pp. 276–285, 10.1002/jnr.490240220; https://pubmed.ncbi.nlm.nih.gov/2585551/
      58. Hasselmo ME; “The role of acetylcholine in learning and memory;”Curr Opin Neurobiol. 2006;16(6):710–715; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659740/
      59. Jones BE; “From waking to sleeping: neuronal and chemical substrates”. Trends Pharmacol. Sci.; 2005; 26 (11): 578–86; https://www.ncbi.nlm.nih.gov/pubmed/16183137
      60. Gao X., Tang X.C. “Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.”Journal of Neuroscience Research. 2006 May 1;83(6):1048-57; https://pubmed.ncbi.nlm.nih.gov/16493671/
      61. Ma, Tuo, et al. “Huperzine a Promotes Hippocampal Neurogenesis in Vitro and in Vivo.” Brain Research, vol. 1506, 19 Apr. 2013, pp. 35–43, 10.1016/j.brainres.2013.02.026; https://pubmed.ncbi.nlm.nih.gov/23454433/
      62. Bohn, Torsten, et al. “β-Carotene in the Human Body: Metabolic Bioactivation Pathways – from Digestion to Tissue Distribution and Excretion.” The Proceedings of the Nutrition Society, vol. 78, no. 1, 1 Feb. 2019, pp. 68–87, doi:10.1017/S0029665118002641; https://pubmed.ncbi.nlm.nih.gov/30747092/
      63. Schmidt, Daniel R et al. “Regulation of bile acid synthesis by fat-soluble vitamins A and D.” The Journal of biological chemistry vol. 285,19 (2010): 14486-94. doi:10.1074/jbc.M110.116004; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863217/

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