NuLiv Science is one of the industry’s leading nutraceutical and dietary supplement formulators. You’ve likely heard of them before – one of their top patented ingredients, AstraGinⓇ, is often used by different brands to help boost their formula’s bioavailability, and is quite effective in doing so. NuLiv Science has quite the research-backed product profile, so when they come to market with a new ingredient, the industry takes notice.
InnoSlim: NuLiv’s new multi-faceted weight loss ingredient
InnoSlimⓇ, one of the newest releases from NuLiv Science, is the ingredient formulator’s first foray into the world of fat-burning. It not only lights up the body’s internal engines responsible for metabolic rate, but its effects reach across multiple mechanisms that are involved with burning fat. InnoSlimⓇ is an ideal ingredient that can help manage weight, blood sugar levels, and energy levels. It’s an innovative twist on the industry’s typical fat-burning ingredients, and is won’t we expect to see more often!
Given that it’s a non-stimulatory ingredient, InnoSlimⓇ is an incredible addition to any weight loss regimen, and is perfectly suited for the following types of supplements:
- Stimulant-Free Fat Burners
- Stimulant-Based Fat Burners
- Glucose Disposal Agents / Nutrient Partitioners
- Carnitine Supplements
There are likely other applications, as the mechanism of action discussed below opens the door to many exciting benefits.
InnoSlim® Supplements: Try it Alone or Alongside Your Favorite Products
There are several great products that contain InnoSlim, such as the Primeval Labs Pyretic stimulant-free fat burner (white bottle) or Sparta Nutrition’s Keto Shred ketone-based caffeinated fat burning powder. However, NuLiv Science sells InnoSlim on its own through Amazon, so you can try it solo or alongside your favorite weight loss aid to see how it performs.
In this post, we’re going to take a deep plunge into the science behind InnoSlimⓇ, covering all of the mechanisms at play and the research behind the latest ingredient from NuLiv Science. Before we get to that, however, make sure you’re subscribed to PricePlow for some of the best supplement deals, news, reviews, and interviews you can find!
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What is InnoSlim®?
InnoSlimⓇ is a patented blend of Astragalus membranaceus and Panax notoginseng — similar to AstraGin®, but formulated to aid weight-loss efforts and reduce symptoms of metabolic syndrome. It targets several mechanisms discussed in detail below, and has a whopping 18 in-vitro studies, 2 in-vivo studies, and one pending human study backing its efficacy.
The science behind InnoSlim®
In this section, we’ll start by talking about the mechanisms that InnoSlimⓇ affects, then discuss how it affects them and makes it so effective!
The metabolism and energy balance
The body primarily uses food for its energy – food that we traditionally measure using the well-known unit of energy, the calorie. Our body’s metabolism controls and regulates how we turn food-based caloric energy into usable energy.
On top of food selection itself, the rate at which the metabolism is able to convert food into energy, however, varies based on multiple factors, such as age, height, and activity levels. Among the key determinants are crucial proteins, enzymes, and factors that reside within the body. Let’s take a closer look at the components that help steer the metabolism towards energy expenditure:
When it comes to fat oxidation and insulin sensitivity, few things are as powerful as adiponectin. This adipocyte-specific protein boosts fatty acid oxidation and inhibits hepatic glucose production, helping the body properly respond and use its available energy supply. In fact, this hormone is so crucial that it’s been directly linked to metabolic issues in multiple ways:
- Higher visceral fat levels (the kind found around the body’s organs that are connected with metabolic dysfunction) are an independent negative predictor of adiponectin levels, meaning that those carrying higher amounts of this type of body fat tend to have less adiponectin.
- Positive correlation with lower blood glucose levels, as well as enhanced insulin sensitivity.
- Lower adiponectin levels are commonly found in individuals who are in danger of developing type 2 diabetes.
Long story short, reduced adiponectin activity makes one more susceptible to fat gain and blood sugar issues, ultimately leading to an array of health issues. Being one of the primary hormones/proteins responsible for fatty acid oxidation, keeping adiponectin circulating is extremely important!
AMP-activated protein kinase (AMPK)
Every time you take a breath, make a movement, or contract a muscle, your cells use adenosine triphosphate (ATP) to do so. ATP is the base energy used by the cells to function, which makes nearly every bodily process highly dependent on it. AMPK assists in regulating the AMP/ATP ratio, which is another way of saying it works to maintain energy balance. AMPK kicks in when the body is in dire need of energy, especially when ATP levels reach lower levels.
Due to its direct involvement with ATP production, AMPK finds itself at the center of a number of crucial processes. Chief among them is metabolism regulation – AMPK gets involved in order to boost energy levels mainly by increasing fatty acid oxidation and glucose uptake. AMPK activation also spikes during exercise due to increased energy expenditure. It also seems to be capable of improving symptoms of metabolic syndrome, with research finding that it helps improve insulin sensitivity. There is also evidence supporting the claim that increased AMPK activity can lead to less visceral fat.
GLUT4 is a transporter protein that, unlike the previous two proteins/enzymes, has a much more streamlined responsibility. GLUT4 is in charge of glucose uptake, shuttling glucose from the blood (where it is toxic when overabundant) into areas of the body that need it. Although there are a number of other transporters similar to GLUT4, this particular protein transporter is most involved with both muscular and fatty tissue.
It’s easy to see that GLUT4 has a very significant relationship with insulin, moving and acting more efficiently when insulin response is high. Lacking enough GLUT4 in either type of tissue can be dangerous, with issues such as insulin resistance entering the fold.
All in all, GLUT4 works to ensure glucose homeostasis, which is imperative for a healthy, well-running metabolism!
SGLT1 works in a similar fashion to GLUT4, however, it does have some slight differences. First, it primarily works within the digestive tract to transport both glucose and galactose, a sugar native to dairy products. Second, and perhaps most importantly, SGLT1 is sodium-dependent, meaning it relies on the presence of salt to conduct its work.
That being said, SGLT1’s involvement with blood sugar aligns it closely with GLUT4 in terms of effects. Not only is SGLT1 a part of the first step of converting sugars into energy, but more SGLT1 activity has been linked to better insulin response and energy balance.
We’ve talked a bit about fatty acids already, but we’ve yet to mention one of the body’s key factors in metabolizing them – acetyl coenzyme A carboxylase (ACC). This enzyme regulates the formation of fatty acids, controlled via responses from insulin, glucagon, and epinephrine. As you would imagine, ACC is quite active when there is a surplus of calories available, storing this excess energy as body fat. While this is the body’s natural response, there seems to be a way to influence it in an advantageous manner.
Acetyl coenzyme A carboxylase phosphorylation (ACC-P) is an incredibly important limiting factor in all of this. ACC is switched off by phosphorylation, which makes it easier for the body to store fat. Inhibiting ACC-P reduces lipogenesis, putting the body in more of a “fat-burning” as opposed to “fat-storing” state.
While it may not be involved directly with metabolic processes, hypoxia-inducible factor-1 (HIF-1) surely has a substantial indirect role. Essentially, this factor maintains cellular homeostasis, specifically when instances of hypoxia (low oxygen) or low energy are of concern. It’s wide-ranging reach thus influences things that relate to the metabolism, such as energy balance and glycolysis.
PAI-1, RBP4, and TNF-⍺
Finally, these last three cofactors and enzymes all share similar relationships as far as InnoSlimⓇ is concerned, especially in terms of body fat:
- Plasminogen activator inhibitor-1 (PAI-1), a biomarker in the fibrolysis system, has displayed a positive correlation to visceral body fat, poor insulin response, and inflammation.[10,11]
- Retinol binding protein 4 (RBP4), a blood retinol transporter, has shown a positive relationship with insulin resistance, obesity, type 2 diabetes, and inflammation.
- Tumor necrosis factor-alpha (TNF-⍺) is a key indicator of increased inflammation. Because it’s mainly held within adipose tissue, increased levels of fat tend to increase the amount of TNF-⍺ present. Additional research shows what this could yield – TNF-⍺ shares a significant relationship with insulin resistance, obesity, and other markers of metabolic syndrome.
Metabolic syndrome – when all of that goes wrong
Each one of those proteins/enzymes/cofactors we’ve just mentioned are extremely important, but that doesn’t mean they always work as they should. Just as those on the road aren’t always going the right direction, or become dangerously unattentive, these metabolic drivers waver in effectiveness, as well. When these key proteins and cofactors grow weak, metabolic syndrome becomes an issue. This makes it extremely difficult to efficiently burn calories, leading to weight gain.
Metabolic syndrome and its negative feedback loop
Metabolic syndrome is a term used to describe a collection of metabolic issues, many of which result in things we’ve already briefly mentioned – obesity, insulin resistance, and inflammation are among the chief consequences. Metabolic functioning and energy balance is incredibly intricate and complex, which makes pinpointing exactly what’s wrong extremely difficult.
That being said, there are a few prominent markers of metabolic syndrome. If you’ve been wondering why we just threw all of those metabolic drivers at you, here’s your answer – practically all of them are involved with metabolic processes, and when poor diet causes them to falter in levels or effectiveness, they can be identified as markers of metabolic syndrome!
Worse, these markers of metabolic dysfunction are often involved in negative feedback loops – a bad metabolism begets more bad diet and insatiable appetite, which begets an even worse metabolism. Our environments make these problems exponentially worse once they begin to stress you out – stress does more than increase cortisol levels – it worsens nearly every parameter discussed above and makes you even more susceptible to unwanted weight gain.
Not all hope is lost, though – you’re surely not on your own when things get out of whack. There are a few things that can help optimize metabolic functioning, and improving any lacking markers of metabolic syndrome is a great place to start. How can you do that? Well, NuLiv Science has provided you a tool for just that!
InnoSlimⓇ combats signs of metabolic syndrome!
As mentioned above, InnoSlimⓇ is a patented blend of Astragalus membranaceus and Panax notoginseng formulated to aid weight-loss efforts and reduce symptoms of metabolic syndrome. It goes after virtually every potential metabolic imbalance we’ve mentioned thus far!! Research on this novel blend is still in its early stages, but existing results are incredibly encouraging, and put the powers of InnoSlimⓇ on full display!
Glucose absorption optimizer
The effects of InnoSlimⓇ are arguably most prominent when discussing glucose absorption. After all, how the body reacts, responds, and deals with glucose sets the table for how well its functioning as a whole. Handling glucose in efficient ways, such as through insulin sensitivity, is a major component of keeping things like fat gain and liver damage to a minimum. InnoSlimⓇ deals with glucose metabolization in multiple ways, too – within the intestine, muscle, and fat!
In the intestines with SGLT1
Early in the digestive process, the body is tasked with dealing with glucose within the digestive tract. Thus, its first line of defense is SGLT1. Typically, it acts to shuttle glucose from the intestine to body tissue, where it’s ultimately either used or stored – often as fat in the liver. InnoSlimⓇ has shown that it can decrease SGLT1 expression by 25%, while also showing capabilities of reducing glucose absorption in the intestine by 41%. This keeps glucose moving through the digestive system, and gives the body a better chance of using only what it needs without storing any excess!
In both muscle and fat cells with GLUT4
Glucose often gets a bad rap, especially in articles such as this one. However, it is an essential, and quite useful, nutrient… when used properly and in appropriate amounts. Muscles love to absorb glucose, which is arguably the most preferable part of the body where glucose can go. Muscles use it to build, as well as maintain blood sugar levels.
Research has shown that InnoSlimⓇ can increase muscular glucose uptake rate by over 100%, effectively doubling the speed at which muscular cells can absorb the sugar. Considering this same study found increased GLUT4 activity as well, we can deduce that this muscle-based glucose transporter was upregulated due to this novel formula!
Increasing GLUT4 expression goes further than that, however. This cofactor being more active also yields benefits within fat cells, too. As GLUT4 promotes more glucose uptake in adipocytes, it can regulate blood glucose activity in fat cells, which thus maintains stable blood sugar levels!
Upregulates AMPK, ACC-P, HIF-1, and adiponectin!
We’ve already touched on how crucial AMPK, ACC-P, HIF-1 , and adiponectin are for metabolic function, especially in terms of efficient fatty acid oxidation. Without each of these factors/compounds firing on all cylinders, the metabolism will struggle to work effectively itself. Being that each of these things are affected in metabolic syndrome, it is great news that InnoSlimⓇ can work its magic on them!
Research testing dose-dependent relationships between these mechanisms and InnoSlimⓇ have come across some incredible findings. Looking at the effect of increasing InnoSlimⓇ dosing in vitro from 0.001 micrograms/mL to 1 microgram/mL, scientists saw that AMPK activity increased from 300% to 400%, while ACC-P expression increased from 200% to 350% of base level. So, not only does a small dose yield incredible effects, but increasing doses may be able to bring even more benefits to the table!
The study didn’t stop there, however – researchers analyzed adiponectin levels as well. Using 0.1 micrograms/mL in a 24-hour saturation period, they found that mRNA levels of adiponectin in fat cells increased by 203%. Furthermore, effects were even more pronounced in a simulated insulin-resistant model – adiponectin activity increased by 348%.
As we saw earlier, these factors, enzymes, and proteins maintain proper energy balance and insulin response, in addition to controlling fatty acid oxidation. When it comes to losing weight, whether you have severe issues in these areas or not, upregulating these processes can yield dividends in terms of fat loss!
Human study – InnoSlim® improves insulin sensitivity
Despite NuLiv Science introducing InnoSlimⓇ fairly recently, they’ve ensured that it’s been tested in-vivo before being put on the market. Test tube studies show promise, but real-life cases are much more resounding, regardless of an ingredient’s effects are tested in humans are tested or not.
Using rats as test subjects, scientists first administered glucose at 1g per kg body weight doses. Then, in a placebo-controlled manner, they introduced InnoSlimⓇ to test the ingredient’s effects. After 90 minutes, InnoSlimⓇ decreased blood sugar levels by 11% while increasing insulin sensitivity by 38%. This study put the in-vitro results to the test, with its results seemingly corroborating previous findings.
While these results are encouraging, no research is as convincing as in-vivo, human studies. NuLiv Science clearly has put a lot of work into getting InnoSlimⓇ studied, and we’re under the impression that human research is within their view for the ingredient. Based on what we’ve seen thus far, we can’t wait to see it!
Astragalus membranaceus and Panax notoginseng – NuLiv Science staples
NuLiv Science is no stranger to the supplement industry – you can find their patented ingredients in a number of products, and we tend to be huge fans of the formulas they are a part of! Each one of their nine offerings has a shared trait, as the company makes use of naturally-derived compounds to drive the formula’s overall effectiveness. Often drawing on roots stemming from ancient practices like Traditional Chinese Medicine, NuLiv Science knows how to extract and dose these substances effectively. InnoSlimⓇ is uniquely similar to a particular NuLiv Science ingredient, and it just so happens it may be its most popular!
InnoSlimⓇ makes use of extracts of Astragalus membranaceus and Panax notoginseng, two herbs that are also used in AstraGinⓇ, arguably NuLiv Science’s most recognized offering. What makes InnoSlimⓇ so interesting is that while it’s derived from the same source as AstraGin, its effects are far from it: InnoSlimⓇ is a fat burner, whereas AstraGinⓇ is a bioavailability enhancer!
Not the same constituents as Astragin
It’s important to note that while AstraGin® and InnoSlim® are developed from the same plants, NuLiv Science identifies specific ginsenosides that are unique to each patented ingredient. In other words — the same plants, but specially-isolated elements of each plant are used to develop each unique ingredient. And both are incredibly effective at doing what their respective labels suggest, too!
This speaks values to how dedicated NuLiv Science is to the research that supports their business. Not only do they spend tons of resources exploring new herbs and formulas, but they also continue research on ingredients they’re already familiar with, innovating new ways in which we can use them. This degree of innovation and persistency is unprecedented, which only makes us appreciate NuLiv Science even more!
Conclusion – InnoSlim® is a welcome addition to the fat-burning / glucose disposal market!
From fat burners to supplements billed as “glucose disposal agents”, we’ve seen this class of ingredients skyrocket in use, as we’re finally beginning to understand the burden that modern Westernized diets put upon our metabolisms. We want to train and drive glucose into our muscles for performance and aesthetics, but we don’t want to have such chronically-elevated blood sugar and insulin levels that we stop burning fat or worse – cause damage to our organs. InnoSlim® is in the white-hot class of stimulant-free ingredients that allows us to attempt to get the best of both worlds.
Make no mistake – fat burners won’t melt weight off on their own, but they can provide a slight boost in your weight loss and appetite-fighting efforts. With a proper training program, diet, and calm state of mind, they can be quite useful. We’re always on the lookout for new ingredients that fall into this category, and NuLiv Science has been leading the way with their extracts lately. When one of the industry’s top ingredient formulators enters the weight loss fray, we take attention!
With InnoSlimⓇ, NuLiv Science is supplying the supplement industry with a potent, stackable, effective stimulant-free fat burning ingredient that can be seamlessly integrated into virtually any regimen. It takes a relatively novel path in order to effectively reach fat stores, utilizing Astragalus membranaceus and Panax notoginseng to reduce cellular fat accumulation, improve glucose uptake, and improve insulin sensitivity. Attacking body fat in this alternative manner, InnoSlimⓇ affects some of the most crucial mechanisms for fat accumulation and storage, ultimately bringing additional avenues for weight loss to the table.
On its own, InnoSlimⓇ can surely be of benefit. Use it as an ingredient in comprehensive fat-burning formula, and you’re talking about a potent, powerful product. NuLiv Science has spent years building up its reputation within the industry, and thus its relationships with supplement brands. Therefore, we can expect to find InnoSlimⓇ on the back of some of the industry’s newest fat burners – based on the science behind it, it’ll be one of the powerhouses driving those labels, too!
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