Bucked Up BUCK NAKED: Mood-Boosting Fat Burner Made with enfinity

Bucked Up is no stranger to trying new things, and even a healthy dose of controversy. Ryan Gardner from DAS Labs launched the company in 2016 aftering pioneering the use of deer antler spray to heal injuries in the top echelons of athletics. The concoction was notably used by NFL linebacker Ray Lewis and golfer Vijay Singh, which led to quite the hysteria a decade back.

Bucked up Buck Naked

Bucked Up Buck Naked is a fat burner powered by enfinity paraxanthine, and when we researched it, we noticed a few ingredients that may support mood improvements on top of the thermogenic effect!

Bucked Up is best known for their pre-workouts, but wait until you see the fat burner we have for you today — and it’s one that may just perk up your mood while boosting energy expenditure.

The company’s penchant for supporting new ingredients has not waned over the past several years, evidenced by the early adoption of paraxanthine, an increasingly-famous caffeine metabolite that we’ve loved since the first time we tried it.

Buck Naked: Fat Loss Powered by Enfinity

The standard for stimulants in the supplement industry is, of course, caffeine. This makes sense since it tangibly decreases feelings of fatigue and actively boosts metabolic activity. As a result, there hadn’t been much motivation to innovate beyond the famous stimulant drug.

But this changed when ING2 pioneered enfinity, their brand name paraxanthine ingredient, now distributed worldwide by TSI Group, a PricePlow partner. Paraxanthine is the primary caffeine metabolite responsible for a variety of beneficial effects paired with the absence of jittery downsides.

enfinity Paraxanthine

And between Bucked Up Babe, which we covered earlier, and the scandalously-named Buck Naked, a new fat burner formula, Bucked Up is big on enfinity.

Now, dive into how Bucked Up Buck Naked works, but first, let’s check The PricePlow for good Bucked Up deals, and check out our video review of the formula:

DAS Labs Bucked Up Buck Naked – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

This area is reserved for Team PricePlow's upcoming videos.

Subscribe to our channel and sign up for notifications so you catch it when it goes live!

Subscribe to PricePlow on YouTube!

Bucked Up Buck Naked Ingredients

Each three-capsule serving of Buck Naked contains the following ingredients:

  • Acetyl L-Carnitine HCl – 1000mg

    Bucked Up Babe Pre-Workout Ingredients

    This is the kind of pre-workout anyone can take, especially later in the afternoon, thanks to the quicker and smoother experience from enfinity paraxanthine compared to caffeine

    Acetyl L-Carnitine (ALCAR) is a preferred form of L-carnitine for nootropic supplements due to its ability to cross the blood-brain barrier.[1] This characteristic is beneficial not only for its nootropic effects but also for its role in fat burners, which include ALCAR for its fatty acid transport capabilities to mitochondria.[2]

    Carnitine’s most significant benefits are observed in individuals likely to be deficient, such as vegans, vegetarians, the elderly, and athletes under heavy exertion.[3,4]

    For nootropic purposes, ALCAR has been shown to offer neuroprotective, neurotrophic, and antidepressant benefits,[5] with studies highlighting its potential to reduce cognitive decline, enhance synaptic response, and improve learning capabilities.[6,7]

    Long story short: if you’re not eating enough red meat, you probably need more L-carnitine, and it will do wonders in more ways than one.

    And on the note of meat eating – there’s also a 24mcg (1000% DV) dose of methylcobalamin, the preferred form of vitamin B12, in Buck Naked as well. This will further support those who aren’t getting enough!

  • InnoSlim – 250mg

    InnoSlim is a patented blend of ginseng and astragalus extracts designed to support weight loss without the need for heavy stimulants.[8-12] This innovative ingredient is backed by human clinical data demonstrating its ability to aid in weight reduction, enhance lipid profiles, decrease insulin resistance, and significantly benefit cardiometabolic health.[13]

    Bucked Up Buck Naked

    Key to its function, InnoSlim influences adiponectin production,[14] a hormone critical for managing fat burning and blood sugar levels, which may have an impact on overall glycemia. This is important because the body is going to beta-oxidize less body fat when blood sugar levels and/or insulin are high and it needs to oxidize glucose first.[15,16]

    Furthermore, InnoSlim activates AMP-activated protein kinase (AMPK, which we consider the “we need energy now” enzyme that controls energy expenditure) and upregulates GLUT4 and SGLT1. These enzymes and transporters are vital for maintaining cellular energy balance and improving glucose uptake in muscle and fat tissues while inhibiting dietary carbohydrate absorption in the digestive tract.[17-19]

    InnoSlim is popular in stimulant-free fat burners, but that’s not what we have here – we indeed have some stimulation, just no caffeine. That’s because paraxanthine is next:

  • enfinity Paraxanthine – 150mg

    Here’s an ingredient that makes Buck Naked really special – enfinity brand paraxanthine. Billed as the next caffeine, a bold claim that this ingredient definitely lives up to, paraxanthine was developed by Ingenious Ingredients (ING2) and is currently distributed by TSI Group.

    Right away, you should be expecting great things from an ingredient with such a pedigree. So does it work? Let us begin…

    Paraxanthine: Sold as enfinity and Distributed by TSI Group

    Paraxanthine is the primary metabolite of caffeine, providing most of caffeine’s beneficial effects. Now you can take it directly with enfinity!

    The upsides of caffeine, without the downsides

    When it comes to the next-gen caffeine claim, the first and most important piece of information you should have is that paraxanthine is actually one of caffeine’s metabolites – your body converts most of the caffeine you ingest into paraxanthine, but that’s not all you get from caffeine consumption.

    Caffeine’s three immediate metabolites are:

    1. Paraxanthine
    2. Theobromine
    3. Theophylline

    All three of these metabolites are, like caffeine, methylxanthine alkaloids with powerful stimulant effects. So why are we interested?

    Well, caffeine is commonly used in pre-workouts for a number of reasons,[20,21] not least for its ability to crank up cellular metabolism.[22,23] Your body is a collection of cells, so when those cells work harder, you can work harder, too.

    The problem is that not everyone metabolizes caffeine the same way.

    While some people can quaff a gigantic pot of black coffee without any problems, others may struggle to sleep after half a bar of chocolate in the morning. For caffeine-sensitive persons, the presence of caffeine in a supplement can be enough to dissuade them from using it.

    Enter paraxanthine.

    As it turns out, paraxanthine is metabolized much faster than caffeine, which makes it a superior choice for anybody, but especially for caffeine-sensitive people.

    But there’s another big benefit in using paraxanthine over caffeine, and to understand what it is, we have to spend a little time talking about caffeine’s other two metabolites.

    Paraxanthine: more effective than caffeine

    Paraxanthine Reaction Time

    Paraxanthine consumption leads to significantly reduced reaction time[24]

    First and perhaps most interestingly, paraxanthine is responsible for the lion’s share of caffeine’s benefits. Research has revealed that paraxanthine, just like caffeine, can accelerate lipolysis (fat burning) by upregulating cAMP/AMPK signaling[22] and diminish feelings of tiredness by blocking the action of adenosine.[23] It’s also highly dopaminergic,[25] which we love since dopamine is basically the neurotransmitter of focus and motivation.

    But paraxanthine doesn’t just resemble caffeine in these respects – it has actually been shown to outperform caffeine in initial research when it comes to boosting muscle growth, strength, and athletic endurance.[26]

    And on the mental side of things, paraxanthine has been shown to better antagonize adenosine, and better improve cognitive performance in domains like psychomotor skills, reaction time, and mental accuracy.[24,27]

    Paraxanthine enables us to avoid theobromine and theophylline

    As awesome as it is that paraxanthine outperforms caffeine, there’s an even bigger benefit we have to discuss, and that is the fact that paraxanthine administration circumvents caffeine’s more troublesome metabolites theobromine and theophylline.

    Paraxanthine Cognition ISSN Poster 2021

    Paraxanthine leads to fewer mistakes![28-31]

    The reason for this comes down to the half-lives of each compound.

    Paraxanthine has the shortest half-life

    As we said above, paraxanthine gets metabolized faster than caffeine – whereas caffeine’s half-life is roughly 4 hours,[32] paraxanthine’s half-life is only ~3 hours.[32]

    The difference is even more pronounced with theobromine and theophylline, which have half-lives of 6 and 7 hours respectively.[32] Those are the metabolites that wreck slow caffeine metabolizers!

    This matters a lot because all four compounds have broadly similar stimulant effects, including theobromine and theophylline. So in light of the very long half-lives those two metabolites have, it makes sense that sensitive individuals would struggle mightily with caffeine largely because of them – and especially theophylline.

    However, the solution is easy – take paraxanthine instead of caffeine. The body doesn’t convert paraxanthine into theobromine or theophylline, and it obviously doesn’t convert paraxanthine into caffeine. So by taking paraxanthine, you sidestep all the issues with the caffeine metabolites.

    MuscleTech enfinity Paraxanthine Explained

    MuscleTech’s Raza Bashir and Ingenious Ingredients (and NNB Nutrition CSO) Shawn Wells join the PricePlow Podcast for Episode #072 to talk about MuscleTech’s new iQ Series launch, using enfinity Paraxanthine!

    Better for slow metabolizers

    The case for paraxanthine becomes even more compelling when you consider that caffeine metabolism is controlled by genes that influence liver enzyme function.[33,34]

    Caffeine-sensitive individuals usually fall into the slow metabolizer category, which means that their individual caffeine half-life is longer than average. For these individuals, the 25% faster half-life of paraxanthine is a compelling value proposition.

    You can read more about enfinity in our main paraxanthine article, or watch Episode #072 of the PricePlow Podcast.

  • Berberine (100mg)

    Berberine stands out as a highly effective glucose disposal agent, crucial for managing blood glucose levels and enhancing metabolic health. Research highlights its ability to significantly lower peak blood glucose levels when taken with meals,[35-38] making it an essential supplement for individuals consuming carbohydrates.

    Berberine PricePlow

    Berberine and its metabolites are our favorite glucose disposal agents

    Berberine activates AMPK,[39] similar to InnoSlim, promoting glucose uptake into cells and facilitating fat burning alongside glucose.[40] Its broad spectrum of benefits includes preventing gluconeogenesis, blocking glucose absorption, improving the health of the microbiome, enhancing blood lipid profiles, reducing oxidative stress, and decreasing inflammation.[35-39,41]

    We’ve covered this ingredient in great depth, and you can read more in our main berberine article, but the data depends on the dosage. For instance, at 1500 milligrams per day, it’s been shown to outperform the drug metformin, but we definitely don’t have that dose here.

    Still, a nice little hit of berberine in a fat burner is something we’ll never turn down.

  • L-Theanine – 100mg

    L-theanine, found in tea leaves, acts as a neurotransmitter in the brain, offering relaxation and anti-anxiety benefits without causing drowsiness.[42-45] Studies suggest that combining L-theanine with caffeine can enhance reaction times, boost working memory, and elevate alertness.[44]

    Although research on the interaction between L-theanine and paraxanthine is yet to be seen, the existing synergy with caffeine hints at promising potential. We’re interested to test this out and see how it performs – Buck Naked may be the first supplement with the combination.

  • CaloriBurn GP – 40mg

    NNB Nutrition CaloriBurn

    Finally, a grains of paradise extract that actually passes lab tests for all clinical constituents!

    CaloriBurn GP, crafted by NNB Nutrition, is a standout ingredient derived from the Aframomum melegueta plant, also known as grains of paradise. This extract is rich in 6-paradol, a phenolic ketone proven to boost calorie burning in brown adipose tissue (BAT) through non-shivering thermogenesis.[46]

    Beyond aiding in weight management, activating BAT offers cardiometabolic advantages, such as reduced blood glucose and triglycerides.[47] Notably, human studies have demonstrated grains of paradise’s effectiveness in burning harmful visceral fat with just a 30 mg daily dose, while a 40 mg dose significantly increased basal metabolic rate shortly after consumption, potentially leading to an additional 400 calories burned daily.[48]

  • Cayenne Pepper Powder – 30mg

    Bucked Up Babe Pre-Workout

    Bucked Up Babe Pre-Workout is a skin-supporting pre-workout supplement made for women with a smooth 100mg dose of enfinity Paraxanthine from TSI Group

    Cayenne pepper is known for its alkaloid capsaicin. Capsaicin’s fat-burning and thermogenic properties, alongside its ability to diminish appetite, support weight loss efforts, particularly during exercise regimens.[49-54]

    Capsaicin not only aids in decreasing body fat with as little as 6 milligrams daily over three months[53] but also improves pain tolerance[55] and sustains metabolism during diet-induced caloric restriction, a crucial factor for maintaining metabolic rate.[56]

    While cayenne pepper and grains of paradise work similarly, we’ve found a trend of doubling down on the ingredients, utilizing both. You won’t ever see us complain about that, especially when using clinically-backed dosages of either (or both).

  • BioPerine – 5mg

    BioPerine, a black pepper extract rich in piperine, enhances bioavailability but stands out for its direct anti-obesity properties. Piperine functions not only as a powerful antioxidant[57] but also inhibits stomach enzymes that typically degrade nutrients, thereby prolonging their integrity and enhancing the body’s absorption.[58]

    It boosts the expression of glucose transporter 4 (GLUT4), facilitating increased cellular glucose uptake and reducing blood glucose levels.[59]

    Piperine and good mood?!

    Paraxanthine: Sold as enfinity and Distributed by TSI Group

    Paraxanthine is the primary metabolite of caffeine, providing most of caffeine’s beneficial effects. Now you can take it directly with enfinity!

    An interesting new study in 2024 found that people with lower serum levels of piperine are more likely to suffer from mood disorders.[60] What makes that really interesting is that piperine is not an endogenous metabolite, so it has to be consumed. And that means that according to this data, people who ingest black pepper and/or piperine are simply in a better mood state!

    So between the enfinity, L-theanine, ALCAR, and piperine from BioPerine, we’re expecting people to feel pretty good mentally from Buck Naked!

Dosage and Directions

Per the bottle, take 3 capsules with water. At 150 milligrams of enfinity paraxanthine, you can take this dosage twice daily, but that will run your bottle out twice as fast.

A good idea is to consider it for early afternoon dosing. Paraxanthine will metabolize quicker than caffeine, and may not affect sleep as much as caffeine does!

Buck Naked and Unafraid of the New

TSI Group: The Exclusive Global Distributor of enfinity paraxanthine

Announced on September 1, 2023, TSI Group (the sponsor of this article) is the Exclusive Global Distributor of enfinity paraxanthine

Bucked Up does not shy away from the new, and this fact is a positive for the entirety of the industry – in particular, the consumers. While caffeine is great, it does have drawbacks for a lot of people. While it does give you a nice kick, that kick is often followed by a gnarly crash. This effect is greatly smoothed with TSI’s enfinity paraxanthine.

Coupled with some top-of-the-line fat burning ingredients like CaloriBurn GP and cayenne, a mood-boosting combination of ALCAR and Bioperine, your mitochondria will be working overtime to melt away the pounds without you cognitively suffering.

DAS Labs Bucked Up Buck Naked – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: PricePlow Staff

PricePlow Staff

PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

No Comments | Posted in | Tagged , , , , , , , , , , , .


  1. Parnetti, L, et al; “Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type”; Eur J Clin Pharmacol. 1992; 42(1):89-93; https://pubmed.ncbi.nlm.nih.gov/1541322
  2. Karlic, Heidrun, and Alfred Lohninger. “Supplementation of L-Carnitine in Athletes: Does It Make Sense?” Nutrition, vol. 20, no. 7-8, July 2004, pp. 709–715, 10.1016/j.nut.2004.04.003; https://pubmed.ncbi.nlm.nih.gov/15212755/
  3. Lombard, K A, et al. “Carnitine Status of Lactoovovegetarians and Strict Vegetarian Adults and Children.” The American Journal of Clinical Nutrition, vol. 50, no. 2, 1 Aug. 1989, pp. 301–306, 10.1093/ajcn/50.2.301; https://pubmed.ncbi.nlm.nih.gov/2756917/
  4. Novakova, Katerina, et al. “Effect of L-Carnitine Supplementation on the Body Carnitine Pool, Skeletal Muscle Energy Metabolism and Physical Performance in Male Vegetarians.” European Journal of Nutrition, vol. 55, no. 1, 23 Jan. 2015, pp. 207–217, 10.1007/s00394-015-0838-9; https://pubmed.ncbi.nlm.nih.gov/25612929/
  5. Veronese, Nicola, et al. “Acetyl-l-Carnitine Supplementation and the Treatment of Depressive Symptoms: A Systematic Review and Meta-Analysis.” Psychosomatic Medicine, vol. 80, no. 2, Feb. 2018, pp. 154–159, doi:10.1097/psy.0000000000000537. https://pubmed.ncbi.nlm.nih.gov/29076953/
  6. Traina, G. June 2016. “The Neurobiology of Acetyl-L-Carnitine.” Frontiers in Bioscience vol.1, 21. 1314-29. https://pubmed.ncbi.nlm.nih.gov/27100509
  7. Passeri, M., et al. 1990. “Acetyl-L-Carnitine in the Treatment of Mildly Demented Elderly Patients.” International Journal of Clinical Pharmacology Research vol. 10,1-2.75-9. https://pubmed.ncbi.nlm.nih.gov/2201659
  8. Lin, Hang-Ching, et al. “Method for Regulating Nutrient Absorption with Ginsenosides”; United States Patent and Trademark Office; Patent US20090181904A1; July 16, 2009; https://patents.google.com/patent/US20090181904A1/
  9. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US20120196816A1; August 2, 2012; https://patents.google.com/patent/US20120196816A1/
  10. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US20120196817A1; August 2, 2012; https://patents.google.com/patent/US20120196817A1/
  11. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US8197860B2; June 12, 2012; https://patents.google.com/patent/US8197860B2/en
  12. Lin, Hang-Ching, et al. “Compound for enhancing nutrients uptake”; Taiwan Intellectual Property Office; Patent TWI271195B; 28-Dec 2004; https://patents.google.com/patent/TWI271195B/en
  13. Lihn, A S, et a;. “Adiponectin: Action, Regulation and Association to Insulin Sensitivity.;” Obesity Reviews : an Official Journal of the International Association for the Study of Obesity; U.S. National Library of Medicine; Feb. 2005; https://www.ncbi.nlm.nih.gov/pubmed/15655035
  14. Wang, Chun-Wen et al. “An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na+/Glucose Cotransporter 1 Gene Expression.” Molecular pharmacology vol. 88,6 (2015): 1072-83. doi:10.1124/mol.114.097352; https://molpharm.aspetjournals.org/content/88/6/1072.long
  15. Sidossis, L, et al; “Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed”; American Journal of Physiology; 270(4 Pt 1):E733-8; April 1996; https://pubmed.ncbi.nlm.nih.gov/8928782
  16. Bonadonna, R; “Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans”; The American Journal of Physiology; 259(5 Pt 1):E736-50; November 1990; https://pubmed.ncbi.nlm.nih.gov/2240211
  17. Richter, Erik A, and Neil B Ruderman; “AMPK and the biochemistry of exercise: implications for human health and disease.”; The Biochemical journal; vol. 418,2; 2009; 261-75; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779044/
  18. Mihaylova, Maria M, and Reuben J Shaw; “The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.”; Nature cell biology; vol. 13,9; 1016-23; 2 Sep. 2011; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249400/
  19. Buhl, Esben S, et al; “Long-Term AICAR Administration Reduces Metabolic Disturbances and Lowers Blood Pressure in Rats Displaying Features of the Insulin Resistance Syndrome.”; Diabetes; U.S. National Library of Medicine; July 2002; https://www.ncbi.nlm.nih.gov/pubmed/12086950/
  20. Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170. https://pubmed.ncbi.nlm.nih.gov/1356551/
  21. Goldstein, Erica R, et al. “International Society of Sports Nutrition Position Stand: Caffeine and Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 5, doi:10.1186/1550-2783-7-5. https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-5
  22. Hetzler, R. K., et al. “Effect of Paraxanthine on FFA Mobilization after Intravenous Caffeine Administration in Humans.” Journal of Applied Physiology (Bethesda, Md.: 1985), vol. 68, no. 1, 1 Jan. 1990, pp. 44–47, doi:10.1152/jappl.1990.68.1.44; https://pubmed.ncbi.nlm.nih.gov/2312486/
  23. Benowitz, Neal L., et al. “Sympathomimetic Effects of Paraxanthine and Caffeine in Humans*.” Clinical Pharmacology & Therapeutics, vol. 58, no. 6, Dec. 1995, pp. 684–691, doi:10.1016/0009-9236(95)90025-x; https://pubmed.ncbi.nlm.nih.gov/8529334/
  24. Yoo, Choongsung, et al. “Acute Paraxanthine Ingestion Improves Cognition and Short-Term Memory and Helps Sustain Attention in a Double-Blind, Placebo-Controlled, Crossover Trial.” Nutrients, vol. 13, no. 11, 9 Nov. 2021, p. 3980, 10.3390/nu13113980; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622427/
  25. Guerreiro, Serge, et al. “Paraxanthine, the Primary Metabolite of Caffeine, Provides Protection against Dopaminergic Cell Death via Stimulation of Ryanodine Receptor Channels.” Molecular Pharmacology, vol. 74, no. 4, 11 July 2008, pp. 980–989, doi:10.1124/mol.108.048207; https://pubmed.ncbi.nlm.nih.gov/18621927/
  26. Jäger, Ralf, et al. “Paraxanthine Supplementation Increases Muscle Mass, Strength, and Endurance in Mice.” Nutrients, vol. 14, no. 4, 20 Feb. 2022, p. 893, 10.3390/nu14040893; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875973/
  27. Xing, Dante, et al. “Dose-Response of Paraxanthine on Cognitive Function: A Double Blind, Placebo Controlled, Crossover Trial.” Nutrients, vol. 13, no. 12, 15 Dec. 2021, p. 4478, 10.3390/nu13124478; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8708375/
  28. Xing, Dante, et al; “Paraxanthine Provides Greater Improvement in Cognitive Function and Psychomotor Vigilance Prior to and Following Running Than Caffeine”; Journal of the International Society of Sports Nutrition, vol. 19, no. sup1, 22 Apr. 2022, pp. 1–69, 10.1080/15502783.2022.2056381; https://blog.priceplow.com/wp-content/uploads/paraxanthine-vs-caffeine-cognitive-function-psychomotor-vigilance-issn-2022.pdf
  29. “Proceedings of the Eighteenth International Society of Sports Nutrition (ISSN) Conference and Expo.” Journal of the International Society of Sports Nutrition, vol. 19, no. sup1, 22 Apr. 2022, pp. 1–69, 10.1080/15502783.2022.2056381; https://www.tandfonline.com/doi/full/10.1080/15502783.2022.2056381
  30. Dickerson, B, et al; “Dose-Ranging Study of Paraxanthine Ingestion on Cognition, Executive Function, and Psychomotor Vigilance”; Poster Presentation at the Seventeenth International Society of Sports Nutrition (ISSN) Conference and Expo; April 2021; https://blog.priceplow.com/wp-content/uploads/paraxanthine-cognition-issn-poster-2021.pdf
  31. Dickerson, B, et al; “Dose-Ranging Study of Paraxanthine Ingestion on Cognition, Executive Function, and Psychomotor Vigilance”; Seventeenth International Society of Sports Nutrition (ISSN) Conference and Expo; April 2021; https://blog.priceplow.com/wp-content/uploads/paraxanthine-cognition-issn-dickerson-2021.pdf
  32. Lelo, A., et al. “Comparative Pharmacokinetics of Caffeine and Its Primary Demethylated Metabolites Paraxanthine, Theobromine and Theophylline in Man.” British Journal of Clinical Pharmacology, vol. 22, no. 2, Aug. 1986, pp. 177–182, 10.1111/j.1365-2125.1986.tb05246.x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401099/
  33. Arnaud, Maurice J. “Pharmacokinetics and Metabolism of Natural Methylxanthines in Animal and Man.” Methylxanthines, 19 Aug. 2010, pp. 33–91, 10.1007/978-3-642-13443-2_3; https://pubmed.ncbi.nlm.nih.gov/20859793/
  34. Nehlig, Astrid. “Interindividual Differences in Caffeine Metabolism and Factors Driving Caffeine Consumption.” Pharmacological Reviews, vol. 70, no. 2, 7 Mar. 2018, pp. 384–411, 10.1124/pr.117.014407; https://pubmed.ncbi.nlm.nih.gov/29514871/
  35. Dong, H., et al; “Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis”;Evidence-Based Complementary and Alternative Medicine, 2012, 1–12; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478874/
  36. Zhang, Y., et al; “Treatment of Type 2 Diabetes and Dyslipidemia with the Natural Plant Alkaloid Berberine”; The Journal of Clinical Endocrinology & Metabolism; 2008; 93(7), 2559–2565; https://www.ncbi.nlm.nih.gov/pubmed/18397984
  37. Yan, H.-M., et al; “Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease”; PLOS ONE; 2015; 10(8), e0134172; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529214/
  38. Pérez-Rubio, KG. et al; “Effect of Berberine Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion”; 2013; Metabolic Syndrome and Related Disorders, 11(5), 366–369; https://www.ncbi.nlm.nih.gov/pubmed/23808999
  39. Kim, Joungmok et al. “AMPK activators: mechanisms of action and physiological activities.”; Experimental & molecular medicine; 2016; vol. 48,4 e224; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/
  40. Zhang, L., et al. “Alpha-Lipoic Acid Protects Rat Cortical Neurons against Cell Death Induced by Amyloid and Hydrogen Peroxide through the Akt Signalling Pathway.” Neuroscience Letters, vol. 312, no. 3, 26 Oct. 2001, pp. 125–128, 10.1016/s0304-3940(01)02205-4; https://pubmed.ncbi.nlm.nih.gov/11602326/
  41. Pang, B. et al. “Application of berberine on treating type 2 diabetes mellitus.”; International journal of endocrinology; 2015; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4377488/#
  42. Juneja, L. R., et al; “L-Theanine-a Unique Amino Acid of Green Tea and Its Relaxation Effect in Humans.;” Trends in Food Science & Technology; Elsevier; 17 Dec. 1999; https://www.sciencedirect.com/science/article/abs/pii/S0924224499000448
  43. Lu, Kristy, et al; “The Acute Effects OfL-Theanine in Comparison with Alprazolam on Anticipatory Anxiety in Humans.”; Human Psychopharmacology: Clinical and Experimental; vol. 19; no. 7; 2004; pp. 457–465; https://espace.library.uq.edu.au/view/UQ:284103
  44. Haskell, C F, et al; “The Effects of L-Theanine, Caffeine and Their Combination on Cognition and Mood.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Feb. 2008; https://www.ncbi.nlm.nih.gov/pubmed/18006208
  45. Lu, K; The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans; Human Psychopharmacology, 19 7: 457-465; 2004; http://espace.library.uq.edu.au/view/UQ:284103
  46. Deshpande, Jayant, et al. “Tolerability of Capsaicinoids from Capsicum Extract in a Beadlet Form: A Pilot Study.” Journal of Toxicology, vol. 2016, 2016, p. 6584649. doi:10.1155/2016/6584649. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811618/
  47. Kim SH, Plutzky J; “Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders”; Diabetes & Metabolism Journal. 2016;40(1):12-21; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768046/
  48. Iwami, Momoe et al. “Extract of grains of paradise and its active principle 6-paradol trigger thermogenesis of brown adipose tissue in rats.” Autonomic neuroscience : basic & clinical vol. 161,1-2 (2011): 63-7. doi:10.1016/j.autneu.2010.11.012 https://www.autonomicneuroscience.com/article/S1566-0702(10)00277-8/fulltext
  49. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-whole-body-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D/core-reader
  50. Juturu, V. “Capsaicinoids Reduce Appetite Response: An Open Label Study in Free Living Population”. OmniActive. 2017. https://ecronicon.net/assets/ecnu/pdf/ECNU-07-0000219.pdf
  51. Urbina, S. “Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals”. 2017. https://www.sciencedirect.com/science/article/pii/S0195666317302623
  52. Rogers, James, et al. “Capsaicinoids Supplementation Decreases Percent Body Fat and Fat Mass: Adjustment Using Covariates in a Post Hoc Analysis.” BMC Obesity, vol. 5, Aug. 2018, p. 22. doi:10.1186/s40608-018-0197-1; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088424/
  53. Vijaya Juturu, OmniActive Health Technologies, Inc Morristown, New Jersey 07960, USA, “Capsaicinoids Enhance Metabolic Rate in Normal Healthy Individuals Using a Novel Metabolic Tracker Breezing Device-An Open Label Placebo Controlled Acute Study”. 2017. https://sciforschenonline.org/journals/obesity/OOA-3-129.php
  54. Morde, Abhijeet, et al. “Capsimax Increases Resting Energy Expenditure in Males Under Fasting State: A Randomized, Double-Blind, Placebo Controlled, Cross-Over Study.” Current Developments in Nutrition, vol. 5, no. Suppl 2, June 2021, p. 514. doi:10.1093/cdn/nzab041_029; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181922/
  55. Snitker, Soren et al. “Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications.” The American journal of clinical nutrition vol. 89,1 (2009): 45-50. doi:10.3945/ajcn.2008.26561 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3151435/
  56. ‌Janssens, Pilou L H R et al. “Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance.” PloS one vol. 8,7 e67786. 2 Jul. 2013, doi:10.1371/journal.pone.0067786 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699483/
  57. Mittal, R., and R.L. Gupta. “In Vitro Antioxidant Activity of Piperine.” Methods and Findings in Experimental and Clinical Pharmacology, vol. 22, no. 5, 2000, p. 271, doi:10.1358/mf.2000.22.5.796644; https://pubmed.ncbi.nlm.nih.gov/11031726/
  58. Kesarwani, Kritika et al. “Bioavailability enhancers of herbal origin: an overview.” Asian Pacific journal of tropical biomedicine vol. 3,4 (2013): 253-66. doi:10.1016/S2221-1691(13)60060-X; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634921/
  59. Carvalho, Eugenia, et al. “Adipose-Specific Overexpression of GLUT4 Reverses Insulin Resistance and Diabetes in Mice Lacking GLUT4 Selectively in Muscle.” American Journal of Physiology-Endocrinology and Metabolism, vol. 289, no. 4, Oct. 2005, pp. E551–E561, 10.1152/ajpendo.00116.2005; https://journals.physiology.org/doi/full/10.1152/ajpendo.00116.2005
  60. Chernonosov, Alexander A, et al. “Untargeted Plasma Metabolomic Profiling in Patients with Depressive Disorders: A Preliminary Study.” Metabolites, vol. 14, no. 2, 6 Feb. 2024, pp. 110–110, doi:10.3390/metabo14020110; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10890195/

Comments and Discussion (Powered by the PricePlow Forum)