Theacrine is a compound that’s chemically similar to caffeine and is known for its potent ability to act as a stimulant.
It’s an alkaloid molecule – which simply means that it’s a naturally occurring substance derived from plant extracts. In its natural form, Theacrine is typically found in a traditional Chinese tea known as Camilla assamica, or as it’s more commonly known, Kucha.
However, its Theacrine’s other unique performance enhancing properties that have some hailing it as the next breakout star of the supplement industry, and it has been added to a few new pre workout supplements and fat burners in 2014.
We expect to see Teacrine (and trademarked compounds such as TeaCor and TeaCrine) a lot more in 2015, so we did some research.
The simple gist is that this compound is extremely promising for its ability to feel good, last long, and keep working, but there is very little human research on it. The bulk of the currently available studies are based on rats, so take it for what it’s worth: it seems safe for all but the most conservative of individuals, but the bulk of its use has been in tea, not as a supplement.
Stimulant- and tea-lovers are likely going to enjoy this ingredient quite a bit:
Energy with No Tolerance Build Up
As many coffee, tea, preworkout, and stimulant users can attest, caffeine begins to lose its kick over time. In fact, previous studies have indicated that our bodies can begin to develop a caffeine tolerance in as little as four days!
However, a recent study published in the journal Pharmalogical Reports found that after seven days of Theacrine supplementation subjects showed no signs desensitization. Simply put, Theacrine users can expect the same level of high potency with nearly every dose, without experiencing a decrease in effectiveness over time.
Mood Enhancing Effects
In our brains, we have a series of chemicals known as neurotransmitters that allow us to transfer signals from one neuron to another. Dopamine is one of the primary neurotransmitters in the brain, and is responsible for controlling pleasure centers in the brain, such as those that make us feel at ease after an intense bout of heavy training.
Studies indicate that a single dose of Theacrine has the ability to elevate levels of dopamine in the brain. Additionally, further analysis showed that after seven days of Theacrine supplementation, the damaging effects of chronic stress and anxiety on the body are significantly reduced.
Improved Liver Function and Detoxification Mechanisms
After seven days of Theacrine supplementation subjects showed no signs desensitization
Oxidation is a naturally occurring process in the body, but too much oxidative stress has been linked to a number of degenerative health conditions such as heart disease, cancer, and Alzheimer’s. However, in order to combat the potential hazards of excessive oxidation, our bodies are equipped with a number of potent antioxidant defense mechanisms, including the body’s most powerful antioxidant and detoxification agent – glutathione. Glutathione, along with several other antioxidant enzymes, is produced in the liver.
Studies indicate that following seven days of Theacrine supplementation subjects showed elevated levels of glutathione inside cells, which suggest that the liver receives a secondary benefit from supplementation.
In addition to being considered a calling card for disease in the body, chronic inflammation can cause permanent degenerative damage to joints and connective tissues as well.
According to a study published in the journal Fitoterapia , Theacrine supplementation appears to have the ability to produce an acute decrease in inflammation.
Not only does reducing inflammation help the body recover more quickly following intense training sessions, but it also helps to keep post workout cortisol levels at bay, allowing you to get back into the gym faster.
Products that contain Theacrine
The following section contains any blog post we’ve written mentioning Theacrine/Teacor/TeaCrine, and will stay up to date indefinitely:
- Primeval Labs Ape Sh*t MAX: Maximum Ape-Like Pre-Workout Energy Posted on: June 17, 2022
- Animal PRIMAL Pre-Workout: Unleash Your Inner Primal Posted on: April 13, 2022
- Animal Cuts Non-Stim: Daily Driver Weight Loss Support Comes Caffeine-Free Posted on: March 15, 2022
- THE Eddie Hall Pre-Workout: A Carb-Enhanced Collab with Myprotein Posted on: December 13, 2021
- Upgrade Your Mentality with 5% Nutrition's Mentality Nootropic Posted on: December 3, 2021
- Mission Critical Meal Replacement Plus: An MRP for Special Operators Posted on: September 29, 2021
- VMI Sports White Heat: High Caffeine High Heat Fat Burner Posted on: June 24, 2021
- 5% Nutrition Core Line Goes Beyond Single-Ingredient Supplements Posted on: April 22, 2021
- Myprotein The Preworkout THERMO: Fat Burning Pre that Doesn't Break the Bank Posted on: April 12, 2021
- Shawn Wells Talks Energy-Boosting Supplements on Ben Greenfield's Podcast Posted on: February 28, 2021
- Primeval Labs Ape Sh*t UNTAMED Pre Workout RTD: No Bubbles, All Gains Posted on: February 26, 2021
- Rule 1 PLAYER1 Boosts Gaming Performance and Rules the Roost Posted on: December 8, 2020
- Myprotein THE Pre-Workout: A Boost When You Need it Most! Posted on: July 28, 2020
- Granite Supplements GX Pre-Workout: Explosive Energy, Maximum Performance Posted on: July 20, 2020
- Nutrex Research Outlift AMPED: Become Unstoppable With High-Stim Energy! Posted on: July 14, 2020
- Axe & Sledge Ignition Switch Kick Starts Your Training Sessions Posted on: July 10, 2020
- Axe & Sledge Seventh Gear Pre Workout Kicks Training Into Overdrive Posted on: April 3, 2020
- Bodybuilding.com’s Scream Pre Workout Returns with Innovative Ingredients Posted on: March 24, 2020
- SteelFit's Steel Slim: A Fat Burner Geared Towards Females Posted on: February 11, 2020
- Darkside Supps Fires Up the Scene with ULTRA STIM Burner! Posted on: September 4, 2019
- Dynamine Achieves GRAS Status With Several New Safety Studies! Posted on: July 5, 2019
- SteelFit Shredded Steel: The Intense Fat Burner That Wires You IN Posted on: January 16, 2019
- Olympus Labs IGNIT3: The Beyond Thermogenic Fat Burner Posted on: November 9, 2018
- Dedicated Nutrition Brings an UNSTOPPABLE Gym Experience Posted on: April 20, 2018
- Beast Mode Black Brings Strong Stims, Yohimbe Dose Disclosed! Posted on: April 12, 2018
- Dynamine: A Neuroactivating "Stimulant" by Compound Solutions Posted on: February 5, 2018
- The Pitbull Labs Pre Workout: Energy and Focus with Bite Posted on: January 22, 2018
- RAW Synergies Thermo Pre: 2-in-1 Fat Burning Pre Workout Posted on: December 21, 2017
- Genius Burn: Smart and Trusted Caffeine-Free Fat Loss Posted on: December 1, 2017
- iSatori Morph Xtreme Brings Energy & PUMPS to iSatori Pre Workouts! Posted on: September 28, 2017
- Sparta Hydra8 BCAA (Discontinued, Hurry and Get It!) Posted on: August 21, 2017
- AZOTH: A Fully Loaded Caffeine-Free Nootropic Posted on: August 18, 2017
- The Socialite by NooWave: A Supplement Remedy for Introverts Posted on: July 28, 2017
- MAN Sports Brain Bridge: Powdered Brain Power! Posted on: July 14, 2017
- Olympus Labs Re1gn Pre Workout: What a Wild Road It's Been Posted on: July 1, 2017
- Dymatize Pre W.O. -- A Mainstream Pre Workout that DELIVERS! Posted on: June 28, 2017
- Metabolic Nutrition's ThermoKal Caffeine-Free Fat Burner Posted on: May 25, 2017
- MTS Clash Pre Workout (Minus Two Ingredients) by Marc Lobliner Posted on: April 21, 2017
- Performax Labs NootropiMax - Free Your Mind Posted on: March 6, 2017
- StimuKal: Metabolic Nutrition's Next Major Fat Burner Posted on: February 14, 2017
- MTS Drop Factor New Formula: Now Longer-Lasting! Posted on: December 14, 2016
- C4 Ultimate: Cellucor's Pinnacle Pre Workout! Posted on: December 13, 2016
- RedCon1 Mental Trigger Brings the BRAIN Gains Posted on: October 12, 2016
- Plexus Edge: Questionably Overpriced Energy Pill? Posted on: July 8, 2016
- iSatori LipoDrex - Nutrient Partitioning Thermogenic Posted on: January 7, 2016
- Cellucor C4 on the Go - C4 Ready to Drink (Plastic) Bottles! Posted on: September 23, 2015
- Lipo 6 RX: New Nutrex Fat Burner with Long-Lasting Energy Posted on: July 10, 2015
- Cellucor C4 Mass - A Bulker's C4.. with FIBER?! Posted on: April 8, 2015
- The Top 10 Supplement Industry News Stories of 2014 Posted on: January 1, 2015
- Theacrine: Caffeine's Long-Lasting Counterpart Posted on: December 15, 2014
- The Cellucor C4 2014 Formula (G4 4th Generation) Posted on: December 11, 2014
There may be other products out there that we haven’t written about. You could also search Google for site:priceplow.com theacrine to see what comes up on both the main PricePlow and the blog.
Unconfirmed sources state that Theacrine tastes absolutely awful, so it might initially come out in mostly pill-based products. Cellucor’s TeaCor, however, is possibly a slightly different form (encapsulated or bonded) that enables it to be in a pre workout and maintain Cellucor’s high taste standards.
Stay updated with PricePlow
To stay up to date with new products and deals, you can click “Get Price Drops” on our pre workout supplements and fat burners pages. If it’s ever released as a standalone product, it will end up in the stimulants section, so you can get alerts there as well.
The TeaCrine Patent
Compound Solutions, the company behind the popular CarnoSyn beta alanine, has a globally exclusive license to distribute TeaCrine. They claim it is “the world’s first IP-protected, branded, and ‘nature-identical’ source of theacrine.”
As we write this, you can’t get Theacrine standalone – Compound Solutions only seems to be selling it to other supplement manufacturers for inclusion in other supplements.
Theacrine has the ability to elevate levels of dopamine in the brain.
The Kucha tea leaves contain anywhere from 1.3-3.4% theacrine. If it behaves anything like tea, a standard 2g tea bag would have about 20-50mg theacrine.
Judging from the label of Cellucor’s new C4, there is a maximum of 35.5mg per scoop. Purus Labs’ Theatrim’s label makes it impossible to postulate – it could be anywhere from 1mg to an unlikely 139mg.
With all of this in mind, it seems that ~25mg would be a very safe and conservative starting point, but this is purely conjecture. Definitely stick with the ingredient labels until we know more.
What were the Rat study dosages?
Compared to the numbers we’re seeing above, the rat studies used relatively high human equivalent doses – 320mg and higher – which we are not seeing in the supplements so far, and seems like a very high dosage — 10x higher than what we’d recommend for now.
Any known side effects?
Although no official “side effects” were reported, toxicity seems to be similar to caffeine. We postulate that at too high of a dose, side effects would be similar to caffeine — nervousness, anxiety, jitters, etc, but can’t be certain just yet.
Meanwhile, the rat studies showed a very high LD50 (median lethal dose), which was about 810mg per kg body weight.
We don’t suggest basing any dosage information off of LD50 data, nor do we recommend converting it to human equivalent. We’re merely pointing out that it seems safe up to a high threshold – just like caffeine.
Theacrine is a unique supplement with valuable performance-enhancing properties that extend well beyond that caffeine. Its ability to reduce factors that inhibit recovery coupled with the fact that continuous use will not result in desensitization or a resulting decrease in performance make it a superior option for hard training athletes looking for supplement that’ll allow them to optimize performance.
Stay tuned to this page, leave a comment, and chat with us on Facebook with any more information!
- Li WX, et al.; Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice. J Agric Food Chem.; 2013
- Feduccia A, et al.; Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.; Pharmacol Biochem Behav; 2012
- Ball KT, Poplawsky A. Low-dose oral caffeine induces a specific form of behavioral sensitization in rats. Pharmacol Rep. 2011 Nov;63(6):1560-3. PubMed PMID: 22358105.
- Wang Y, et al. Theacrine, a purine alkaloid with anti-inflammatory and analgesic activities. Fitoterapia. (2010)
- Oven, M; Purus Labs Secures Deal to Introduce Patent-Pending TeaCrine to the World With New Thermogenic TheaTrim; PRWeb; Aug 2014
- Compound Solutions Announces Exclusive Distribution License with Ground-Breaking Compound, TeaCrine
- Chuang-xing, Y; New Discovery of Pattern of Purine Alkaloids in Wild Tea Trees; School of Life Sciences,Sun Yat-sen University; 2003
- Kihlman, B; 1,3,7,9-tetramethyluric acid–a chromosome-damaging agent occurring as a natural metabolite in certain caffeine-producing plants.; Mutat Res; 1977