C4 Ultimate Strength: Dual Peptides Make for the Best C4 Formula Yet

C4 Ultimate Strength

C4 Ultimate Strength: The best C4 formula we’ve ever seen! With TWO peptides (PeptiStrong & PeptiPump) and an incredible stim blend, there’s energy, strength, performance, & pump

There’s currently one really hot buzzword in the supplement and pharmaceutical industries alike. That word is peptides.

Thanks to breakthroughs in computing power and statistical analysis, science has now identified thousands of amino acid chains that have outsized effects on important aspects of human physiology.

Last year we wrote a lot about PeptiStrong, a fava-bean-derived peptide network that has some incredible pro-anabolic effects. PeptiStrong was developed by Nuritas, a biotech company that used artificial intelligence to find the best source for the peptides they sought.

But now, thanks to Nutrabolt, another Nuritas peptide has hit the market, and it’s in a pre-workout series we’ve all come to respect:

C4 Ultimate Strength – A Powerful Pre-Workout with PeptiStrong and PeptiPump

The product line we’re talking about is C4 Ultimate, and the product we’re specifically zeroing in on today is C4 Ultimate Strength, which, to us, is the most exciting pre-workout of all of the ones we’ve seen in Nutrabolt’s new C4 5th Generation Launch of 2024.

What is PeptiPump?

Nutrabolt has announced what PeptiPump is inside of the new C4 Gen5 series. What is it?! An ACE Inhibitor peptide network!

This is in part because it includes PeptiPump, a peptide network focused on creating massive pumps through vasodilation, in addition to the PeptiStrong that was in the previous generation.

So now we’re getting both of these incredible peptides in the same product.

The release of this C4 generation is a watershed moment for the nutritional supplement industry. It marks the beginning of what we think is destined to be a very long and very rewarding chapter in supplement science – the era of peptide dominance.

Of course, peptides aren’t the only thing in C4. This formula also features an impressive array of familiar nutraceuticals and botanical extracts.

Let’s get into how this works, but first, check the PricePlow news and deals:

Cellucor C4 Ultimate Strength – Deals and Price Drop Alerts

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C4 Ultimate Strength Ingredients

In a single 27.5 gram (1 scoop) serving of C4 Ultimate Strength, you get the following:

Endurance & Performance Complex – 10,650 mg

  • CarnoSyn Beta-Alanine – 3,200 mg

    C4 Ultimate Strength Ingredients

    Beta-alanine is one of the supplement industry’s favorite ergogenic aids – an ergogenic aid being defined as any substance, device, technique, or treatment that enhances an individual’s energy utilization, efficiency, or performance during exercise.

    Together with the amino acid L-histidine, beta-alanine is a precursor to a dipeptide molecule called carnosine, which the body uses to detoxify lactic acid in muscle tissue.[1] Since lactic acid (AKA lactate) accumulation is a major driver in the onset of muscular fatigue, slowing down its building via beta-alanine supplementation is an effective endurance-boosting strategy.

    The peer-reviewed literature indicates that supplementing with beta-alanine can improve athletic performance by extending an individual’s time to exhaustion,[2,3] increasing power,[4] and, when taken long term, encouraging a lean body composition.[5]

    Two big meta-analyses of the literature on beta-alanine found that for many different kinds of exercise and sports performance, a daily 3,200 mg dose of beta-alanine can greatly increase endurance and reduce fatigue. However, it appears that beta-alanine does this best for exercise conducted at a specific level of intensity – that which can be sustained for 30 seconds to 10 minutes.[1]

    Why we like CarnoSyn

    CarnoSyn, a patented formulation of beta-alanine, has been developed and marketed by Natural Alternatives International. Widely recognized within the supplement industry for its superior quality, it stands out as one of the premier brands of beta-alanine available.

    Natural Alternatives maintains a strict policy of quality control, licensing the use of their ingredients only when appropriately dosed. This commitment to quality is evident in C4, where users benefit from the clinically-validated 3,200 mg dose.

  • VELOX patented performance blend

    C4 Ultimate Strength

    VELOX is a blend of amino acids patented[6-9] by the Kyowa Kirin company — here in America, we work with Kyowa Hakko USA, and they actually manufacture Velox right here in the states in Missouri! In case you don’t know, Kyowa is renowned for the purity and quality of its amino acid supplements, and actually pioneered a process of amino acid fermentation that is now the industry standard.

    The idea behind combining these two specific aminos, namely citrulline and arginine, that they have a synergistic effect on your body’s production of nitric oxide (NO).[10-12] That is, the combination of these aminos works better to upregulate NO than either one alone.

    The basic reason for this is that citrulline inhibits an enzyme called arginase, which ordinarily degrades arginine before it can be digested and absorbed by the body.[13] This makes arginine more effective, plus, as we’ll see, citrulline has NO-boosting effects of its own.

    • L-Citrulline – 3,000 mg

      Citrulline is classified as a non-essential amino acid, which means that your body can make citrulline on its own, so long as it’s supplied with the necessary chemical precursors. The catch is that there’s a limit on how fast your body can synthesize it – and the amount you need, especially under circumstances like injury or illness, dramatically outstrips your body’s ability to make it.

      Citrulline Fatigue Reduction

      On its own, a 2.4 gram dose of Kyowa Quality citrulline was also enough to significantly improve multiple markers of fatigue, as assessed immediately following exercise using the visual analog scale (VAS).[14]

      So how does citrulline work? It increases your body’s ability to synthesize nitric oxide (NO).[2] Although arginine was actually the standard NO-boosting ingredient for a long time, citrulline gradually supplanted it owing to the later’s superior oral bioavailability.[3] But like we said above, the combination of citrulline and arginine makes arginine more effective, by inhibiting arginase and sparing arginine from the first pass effect.[4]

      The reason we want more NO is that NO triggers vasodilation, a phenomenon where your arteries grow in diameter, allowing a greater volume of blood to flow through them, and improving delivery of blood to microvessels that are sensitive to changes in circulatory status.

      With circulation improved, oxygen and nutrients can reach your cells more efficiently, leading to better athletic performance. At the same time, the improved circulation also helps your body get rid of metabolic wastes like lactic acid, leading to improved recovery from exercise.

      Arginine Citrulline Performance

      With the improved arginine status, we get improved nitric oxide levels, better blood flow and circulation… and ultimately, better performance![11]

      It’s no wonder, then, that studies on citrulline have demonstrated its ability to:

      • Increase cellular oxygen utilization, thus improving performance at max intensity[5]
      • Prolong athletic endurance – one study found that citrulline supplements enabled subjects to perform 53% more bench press reps than the placebo group[15]
      • Decrease post-exercise soreness, by roughly 40%.[15]
    • L-Arginine – 3,000 mg

      So what benefits does arginine give us? Since your body actually converts citrulline into arginine before the arginine gets turned into NO, it’s safe to say that all the benefits of citrulline supplementation are associated with arginine as well.

      The conversion pathway looks like Citrulline → Arginine → NO. So with this combined blend of amino acids, you’re definitely getting tons of NO upregulation.

      An ingredient made in the USA!

      You can read about Kyowa Hakko USA’s American facility in our article titled Kyowa Quality: Trusted Supplement Ingredients Made in the USA and Amino Acids Made in the USA: Kyowa Quality’s Citrulline, Glutamine, and Arginine. We love that Nutrabolt is leaning into this American-made ingredient duo!

  • BetaPower Betaine Anhydrous – 1,250 mg

    Betaine, AKA trimethylglycine (TMG), is an ergogenic aid like beta-alanine, but it uses a distinct mechanism of action.

    Methyl donor
    Velox Logo

    Discussed above, Velox is a patented ingredient combining L-arginine with L-citrulline

    “Ergogenic aid” is a pretty broad category, and there are many different mechanisms of action that can create an ergogenic effect. One of the most common, though, is the ability to increase your cells’ production of adenosine triphosphate (ATP), the energy currency that your cells use to perform all their metabolic tasks. You can think of ATP as your cells’ gasoline, so it should make intuitive sense that giving them more ATP can translate to improved cognition and better athletic and cognitive performance.

    And as it turns out, this is precisely what betaine does – it upregulates ATP by enhancing mitochondrial respiration.[16]

    Betaine increases ATP synthesis by donating methyl groups (chemical formula CH3) to sites in the body where those methyls are required for the performance of vital cellular functions.[17] In fact, among all methyl donors known to science, betaine is one of the most potent.[18]

    One of methyl group’s most crucial roles is helping the body regulate blood levels of homocysteine, an amino acid that’s generated when your body metabolizes another amino acid called methionine. If homocysteine levels rise too far, the result is a substantially elevated risk of cardiovascular disease,[19] so we want to keep that under control as best we can.

    Since homocysteine regulation is highly dependent on methylation, betaine supplements can significantly decrease blood homocysteine.[20] This means betaine supplementation can be a great investment in your long-term cardiovascular health and athletic performance.

    Osmolyte effects

    Methyl donation isn’t the only way that betaine can improve performance, though. It’s also an osmolyte, meaning it can positively affect cellular water balance.

    Betaine Benefits

    The placebo effect started strong with this group. But… the real gains obliterated placebo in due time with betaine!

    More specifically, betaine can push extra water into your body’s cells, leading to a desirable state called cellular hyperhydration, in which cells benefit from improved nutrient availability[21,22] and are more resistant to the debilitating effects of heat.[23]

    Betaine studies

    At 2.5 grams or more (which we don’t have here), the peer-reviewed literature on betaine shows that it can:

    • Increase strength[24,25]
    • Increase power[23,24,26-28]
    • Improve body composition[22,29,30]

    In one particularly impressive study, collegiate women who took betaine alongside weight training lost 4 pounds more body fat than the placebo group.[29]

    So with that said, we’re going to have to look forward to a Nutrabolt-led muscle builder to help top off the 1.25 grams inside here.

  • PeptiPump Bioactive Lentil Peptides – 200 mg

    PeptiPump is a novel peptide network identified and isolated from lentils, by Nuritas with the aid of AI-driven research tools. It consists of peptides that have been shown to inhibit angiotensin-converting enzyme (ACE), a mechanism with significant vasodilatory effects. This mechanism’s lower blood pressure is why pharmaceutical ACE inhibitors are a prescription treatment for hypertension.

    What is PeptiPump?

    Nutrabolt has announced what PeptiPump is inside of the new C4 Gen5 series. What is it?! An ACE Inhibitor peptide network!

    Because ACE inhibition is such a powerful strategy for increasing muscle blood flow and oxygenation, food-derived ACE-inhibiting peptides have long been discussed as a possible tool for improving circulatory dynamics.[31-33] The big issue that needed to be solved was bioavailability – and PeptiPump appears to have solved that problem, as it’s been shown to survive gastrointestinal digestion and absorption.[34,35]

    This is Nuritas’ complement to PeptiStrong, a more anabolic-focused peptide that we’ll be discussing below.

    As of March 2024, we still don’t have any peer-reviewed, journal-published research on PeptiPump itself. However, Nutrabolt and Nuritas released a statement explaining what the ingredient was, and we posted it in our article titled PeptiPump: A Lentil Protein Hydrolysate Containing Bioactive Peptides.

    A study published in 2023 titled “Development of lentil peptides with potent antioxidant, antihypertensive, and antidiabetic activities along with umami taste”[36] discusses some of the underlying research that may be at play here, but we look forward to research specifically performed on PeptiPump itself. When it’s out, we’ll update the article linked above.

Muscle & Strength Matrix – 8.05 grams

  • Creatine monohydrate – 4 grams

    Although we haven’t run the numbers, we’re willing to bet that more papers have been written about creatine than any other dietary supplement.

    C4 Ultimate Strength Benefits

    The reason is simple – creatine works, and it works well. Remember what we wrote in the betaine section about creating ergogenic effects through ATP upregulation? Well, that’s exactly what creatine does, too.[37-40]

    Increasing ATP stores, and hence cellular energy availability via creatine supplementation has been shown to do the following:

    • Increase power[41,42]
    • Promote muscle gain[43-46]
    • Increase sprint speed[47-49]
    • Augment cellular hydration[50]
    • Reduce fatigue[51-53]
    • Improve sense of overall well-being[54-56]
    • Enhance cognitive performance[57,58]
    • Increase serum testosterone[59-63]

    Besides the few dozen studies we’ve covered in this impressive list, there are, without exaggeration, hundreds of similar peer-reviewed studies and meta-analyses all showing the same thing: creatine is a totally kickass supplement for performance, both mental and physical.

    The 4 gram dose is adequate – and we have more coming from creatine nitrate!
    Creatine ATP Shuttle

    The Creatine ATP Shuttle

    You’ve probably noticed that Nutrabolt C4 uses four grams of creatine, instead of the usual five. Don’t worry, though – there are two things happening here.

    1. First, we have more creatine coming from the 1.5 grams of creatine nitrate, which will fill in that fifth gram.
    2. But even if that weren’t the case, this is still an efficacious dose! Data from the National Health and Nutrition Examination Survey (NHANES) indicates that Americans get, on average, 0.54 grams of creatine per day from food, with an average daily creatine loss of 2 grams per day.[64]

    This means that even if you got zero grams of creatine per day from diet, a 4-gram dose would still be twice as much as you need to cover your daily creatine requirements. Yet Nutrabolt didn’t leave that to chance, they continue to rely on creatine nitrate which brings creatine alongside the nitrate-based pumps.

    Bottom line, this dose on its own works great, but C4 Ultimate Strength isn’t done yet — there’s more creatine on the way.

  • PeptiStrong bioactive fava bean peptides – 2,400 mg

    While PeptiPump is focused on enhancing blood flow, PeptiStrong is Nuritas’ more anabolic peptide network.


    Boost your muscles’ natural performance and recovery abilities with PeptiStrong, a natural anabolic peptide network found in fava beans.

    Now that we’re talking about anabolic mechanisms and muscle growth, we should be careful to distinguish between dietary protein and peptides. While peptides are technically proteins, we use the term peptide as a kind of short-hand to refer to proteins that have been identified for their informational effects on human physiology. By altering epigenetic and hormonal factors, peptides can have dramatically non-linear effects on human health.[65-67]

    By manipulating these key bio-informational levers through peptide supplementation, we can help alter body composition without relying on changes to caloric intake.

    And that’s exactly what PeptiStrong has been shown to do. It’s made up of over 400 different peptides[68] that were selected for their ability to upregulate mammalian target of rapamycin (mTOR), a switch that controls the synthesis of new muscle tissue.

    Human study 1: PeptiStrong’s can increase strength gains during recovery from muscle damage

    In a randomized, double-blind, placebo-controlled study from 2023, researchers recruited 30 healthy, recreationally-active men between the ages of 30 and 45. Subjects completed a baseline strength test on day 1 of the study period, and were then given either 2.4 grams of PeptiStrong or a placebo every day for two weeks.[69]

    On day 15, subjects stopped their prescribed treatment, and then completed a followup physical fitness assessment, which consisted of a stationary bike warmup, followed by a knee flexion and extension test designed to measure knee strength. The test consisted of 5 warmup reps, gradually increasing from 60% to 100% of the subjects’ maximum effort, followed by 2 sets of 5 reps performed at 100% effort.[69]

    This particular leg exercise is known to cause significant muscle damage,[70,71] making it an ideal test to use for the purpose of assessing muscle growth and recovery.

    The study authors tested the subjects’ recovery progress by analyzing a variety of biomarkers 48 and 72 hours after the initial test day – that is, the 17th and 18th days of the total study period – while the supplementation regimen resumed.[69]

    PeptiStrong Strength Recovery Study

    the PeptiStrong group recovered quicker and reported decreased soreness relative to the placebo group. “Delta Peak Torque/BW” means the alteration in peak torque capacity relative to body weight.[69]

    At the 72 hour mark, the study authors found something astonishing – the PeptiStrong group had not only fully recovered from the muscle damage caused by the test, but had actually increased their strength above the baseline! By comparison, the placebo group had, at this point, not even fully recovered their baseline level of strength.[69]

    Moreover, the PeptiStrong group scored significantly better on a fatigue index, which indicates a significant increase in muscular endurance.[69]

    Finally, key biomarkers like myokine activity indicated that the PeptiStrong group had a heightened inflammatory response post-workout, which is a period where inflammation can actually benefit the anabolic response.[69]

    PeptiStrong Strength & Recovery Study: Biomarkers

    The PeptiStrong group had higher blood concentrations of various myokines that centrally implicated in muscle growth.[69]

    Even more amazing is PeptiStrong’s effect on myostatin, a protein that is known to inhibit muscle protein synthesis:

    The potential significance of this is hard to overstate – sports nutrition has been trying for decades to identify a viable myostatin inhibitor, which holds such incredible anabolic promise that it’s the closest thing this industry has to a holy grail. Needless to say, it’s absolutely amazing that we may finally have one in PeptiStrong.

    Recovery after immobilization-induced muscular atrophy

    Another study, also from 2023, looked at PeptiStrong’s ability to maintain muscle tissue during forced immobilization. In this study, 30 young men were recruited to wear a plaster cast for 7 days. Since this cast completely restricted knee flexion, it was a way to create profound muscular atrophy in the affected leg.[72]

    The study participants were randomized to take either 20 grams of PeptiStrong or 20 grams of milk protein daily. The idea behind this study design is to demonstrate PeptiStrong’s disproportionate effects on muscle growth by dose-matching it with an ordinary dietary protein.

    The researchers found that, once the casts came off, the PeptiStrong group recovered lost muscle four times faster than the milk protein group![72]

    PeptiStrong Myofibrillar FSR (Myofibrillar Protein Fractional Synthesis Rate)

    Relative to the milk protein (control) group, the PeptiStrong group had a significantly higher myofibrillar protein fractional synthesis rate (FSR), indicating a faster recovery from muscle loss.[72]

    Despite the fact that both groups experienced approximately the same extent of muscle loss, once the subjects were able to move their legs, the PeptiStrong group recovered far faster.

  • Creatine Nitrate (as NO3-T) – 1,500 mg

    Creatine nitrate comes with all the benefits of creatine that we discussed in the creatine monohydrate section, plus the benefits of nitrates. C4 is well-known for their use of creatine nitrate, and we’re happy they kept it in the 5th Generation. This simultaneously gets us up to about 5 grams of creatine, but also adds in the pumps from the nitrate side:

    Benefits of nitrates

    Nitrates are desirable for the same reason as citrulline and arginine – they help the body create NO, albeit by a slightly different pathway. When nitrates are ingested, oral bacteria chemically reduce those nitrates to nitrites. When mixed with saliva, those nitrites can convert to nitric oxide in the acidic environment of the stomach and gastrointestinal tract, facilitated by enzymes like salivary peroxidase.[73-75]

    Because supplemental nitrates can increase NO production, they come with the usual NO-related benefits:

    • Better circulation[76]
    • Increased aerobic efficiency[76-79]
    • Increased strength[80,81]
    • Enhanced cellular energy production[81-83]
    Studies performed specifically on creatine nitrate

    As for creatine nitrate itself, there are studies showing that it can support significant increases in bench press power,[84-86] leg press strength,[85] and leg press endurance.[85]

    Additionally, it also has a great safety profile,[84,87] which isn’t surprising given its mechanisms, ATP-boosting capabilities, and the fact that Nutrabolt has long relied on the ingredient without problems!

  • elevATP Ancient Peat and Apple fruit extract – 150 mg

    ElevATP is made up of polyphenol antioxidants derived from ancient peat moss and apples, and identified for their ability to increase adenosine triphosphate (ATP) production.[88]

    ElevATP Bioactive Components

    ElevATP contains polyphenols that are capable of triggering increased ATP synthesis.[89]

    We love elevATP because, as we discussed earlier, ATP is crucially important for health and performance. Since it’s the form of energy your cells actually use, your body’s ability to supply those cells with ATP is a possible bottleneck on athletic performance. In those cases, supplements like elevATP can improve performance.

    One 2016 study showed that participants who took 150 milligrams of elevATP for two months gained more strength, jump speed, and power, compared to a placebo.[90] As the study authors point out, ATP’s ability to induce vasodilation is a key mechanism behind these effects.[90]

Ultimate Energy, Focus & Stimulant Matrix – 1.366 grams

The physical side of things is, after all, only half of a good workout – to feel and perform your best in the gym, it’s important to have your mood, energy, and focus down as well. That’s what this blend is designed to help you achieve.

  • L-Tyrosine – 1,000 mg

    The amino acid tyrosine is a great supplement for helping manage the stress of training and body recomposition.

    Tyrosine serves as a building block for catecholamine neurotransmitters such as dopamine, adrenaline, and noradrenaline,[91-93] which are all crucial players in regulating focus, motivation, and energy levels. Additionally, adrenaline and noradrenaline play a role in appetite suppression,[94] potentially aiding in making dietary restrictions more manageable.

    Additionally, tyrosine can increase your thyroid’s production of the hormones triiodothyronine (T3) and thyroxine (T4).[95,96] This is potentially a big deal since dieting and exercise are both stressful,[95,96] and the combination of these behaviors can be particularly bad.

    Tyrosine Derivatives

    It’s easy to see why we like tyrosine so much – its derivatives bring the intensity and focus! Image courtesy Wikimedia

    Maintains cognition during sleep deprivation

    We all know that nothing can tank your physical performance – or your ability to build muscle – quite like sleep deprivation.

    Unfortunately, not getting enough sleep can really hammer your brain too, and compromise cognitive performance. But fortunately, tyrosine can help with this – according to research performed by the U.S. military, tyrosine is actually better at restoring sleep-deprived persons’ cognitive abilities to baseline than caffeine.[97,98]

  • Caffeine Anhydrous – 300 mg

    Caffeine is a methylxanthine stimulant capable of crossing the blood-brain barrier,[99] which gives it a high degree of activity in the central nervous system.

    As the vast majority of us know from intimate personal experience, caffeine is great for improving mood, enhancing focus, optimizing athletic performance, and making the user feel more energetic.[100] Caffeine’s primary energizing mechanism is actually better understood as an anti-fatigue mechanism – it inhibits the action of adenosine, a chemical that builds up in the brain while we’re awake and creates mental fatigue.[101,102]

    Caffeine Energy Expenditure

    Caffeine increases energy expenditure by roughly an extra 0.15 calories per minute. Not huge, but we’ll take it! But what happens when the dose gets absurd?

    However, caffeine does also give us more energy in the most literal possible sense of the word – it helps your cells produce more cellular energy by inhibiting an enzyme called phosphodiesterase, which is responsible for degrading a messenger molecule called cyclic adenosine monophosphate (cAMP).[100-104]

    Caffeine can also help you burn fat,[105] up to 50% faster than normal.[106] A 2020 meta-analysis of 19 studies concluded that measurable upticks in fat oxidation can be observed with doses as small as 3 milligrams of caffeine per kilogram of bodyweight.[107]

    On the sports performance side of things, caffeine supplementation can increase strength, power, speed, and endurance.[100,101,103,105,106] Cognitively, caffeine can help increase attention, alertness, reaction time, and working memory.[108-110]

  • Dynamine (as Methylliberine) – 50 mg

    Dynamine is a trademarked form of methylliberine, an alkaloid that naturally occurs in Camellia sinensis (tea) leaves[111,112] and can exert stimulant effects without causing cardiovascular effects like vasoconstriction.[111-114] Much like caffeine, methylliberine can upregulate dopamine and noradrenaline while antagonizing adenosine.[111-114]

    C4 Ultimate Strength

    If you need a refresher on how adenosine antagonism works, scroll back up to the caffeine anhydrous section of this article.

    In our anecdotal experience, Dynamine tends to add some “pop” to pre-workout formulas, putting Nutrabolt C4 a cut above the competition. It’s sometimes paired with its counterpart below:

  • TeaCrine (as Theacrine) – 10 mg

    Theacrine is another alkaloid and close chemical cousin of caffeine.[115] Like caffeine, it’s a potent stimulant, and occurs naturally in Camellia kucha, a traditional Chinese tea variety known colloquially as just kucha.[116] Also like caffeine, theacrine can increase your mental and physical energy by antagonizing adenosine[117] and inhibiting the enzyme phosphodiesterase.[118] Theacrine is also dopaminergic,[119] making it great for enhancing focus, motivation, and mental energy.

    Where theacrine differs from caffeine is in its pharmacodynamics – a small but compelling body of research indicates that unlike caffeine, chronic theacrine use does not produce drug tolerance.[119]

    Perhaps the most intriguing evidence of theacrine’s ergogenic effect comes from a 2019 study where theacrine boosted time to exhaustion at 8% VO2max by 27-38%.[120]

    PeptiStrong Myostatin

    PeptiStrong’s downregulation of myostatin, a protein that inhibits the anabolic response.[69]

    Theacrine also seems to be a sort of liver tonic, as demonstrated in an animal study where it attenuated stress-related liver damage.[116]

    There’s a good bit of synergy on theacrine, methylliberine, and caffeine,[121-123] and we’re excited to see them combined. Note, however, the three studies cited here using them all together had different doses.

  • Toothed Clubmoss (Huperzia serrata) aerial parts extract (std. 1% Huperzine A) – 5 mg

    Huperzine A, an alkaloid derived from Huperzia serrata, acts as a potent inhibitor of acetylcholinesterase, the enzyme accountable for breaking down the neurotransmitter acetylcholine (ACh).[124] By extending the action of ACh through acetylcholinesterase inhibition, Huperzine A increases its effectiveness.

    Here at PricePlow, we often refer to ACh as the learning neurotransmitter thanks to the key role it plays in learning and memory consolidation.[125] When ACh levels increase, it improves a wide variety of cognitive functions, ranging from learning and memory to balance and coordination.[126,127]

    Huperzine A can also promote neurogenesis, the formation of new neurons.[128]

  • Rauwolfia vomitoria root bark extract – 1 mg

    Rauwolscine is a compound found in the plant Rauwolfia serpentina, also known as Indian snakeroot. It is chemically similar to yohimbine, and sometimes referred to as alpha-yohimbine.

    C4 Generation 5 Lineup

    Like yohimbine, rauwolscine is known for its ability to interact with adrenergic receptors in the body, particularly as an antagonist of the alpha-2 adrenergic receptors. This interaction can have various physiological effects, including the potential to increase energy expenditure,[129] suppress appetite,[130] and promote fat loss.[131]

    On the cognitive side of things, rauwolscine’s ability to activate the sympathetic nervous system can improve focus in a big way.[132]

Other Ingredients

Besides its impressive array of nutraceuticals and botanical extracts, Nutrabolt C4 also has some solid vitamin and mineral support, we’re very happy they’ve switched to the high-quality B-vitamins in all of their 2024 C4 formulas!

  • Vitamin B6 (as Pyridoxal-5-Phosphate) – 3.4 mg (200% DV)

    Pyridoxal-5-phosphate (PLP) is the active form of vitamin B6. More specifically, this vitamin functions as a coenzyme, which can be converted into pyridoxamine 5′ phosphate (PMP) as needed. Together, these enzymes coordinate several hundred metabolic processes throughout the body, the most important of which is probably protein metabolism, which can’t take place without enough PLP and PMP.[133]

    Vitamin B6 plays an important role in homocysteine regulation,[133] much like betaine (which we discussed above.)

    It’s an important building block for neurotransmitters that are crucial for mood, motivation, and perceived energy.[133]

    Vitamin B6 Metabolism

    Vitamin B6 Metabolism

    Your body needs B6 to synthesize hemoglobin, which is a pretty big deal for anybody who cares about optimizing athletic performance.

    Vitamin B6 can also modulate immunity, gluconeogenesis, and glycogenolysis, the chemical degradation of glycogen for usable energy.[133]

    Supplementing with B6 is associated with a lower risk of cardiovascular disease, cancer, and cognitive dysfunction.[133]

  • Folate (as 6S-5-Methyltetrahydrofolate calcium salt) – 100 mcg DFE (25% DV)

    Compared to other forms of folate (vitamin B9), 5-MTHF shows far better bioavailability.[134-136]

    Being deficient in folate can increase the likelihood that you’ll develop the following issues:

    • High homocysteine[137,138]
    • Fetal birth defects[139]
    • Cancer[140]

    This form of folate, 5-MTHF, is a form your body can synthesize endogenously from folic acid, through the activity of an enzyme called methylenetetrahydrofolate reductase (MTHFR). One study found that up to 40% of people[141] have at least one of the genetic polymorphisms that can impair MTHFR functioning, which increases the carrier’s risk of folate deficiency and, thus, elevated homocysteine blood levels.

    Vitamin B9

    In this long and complex conversion pathway, your body regulates homocysteine through the conversion of dietary folate (usually in the form of folic acid). One important part of this process is an enzyme called methylenetetrahydrofolate reductase (MTHFR) whose activity is often limited in genetically susceptible individuals.

    Fortunately, there’s an easy way around this genetic bottleneck – by supplementing directly with the 5-MTHF form of folate, you can circumvent the MTHFR enzyme.

    Studies show that 5-MTHF supplements have the ability to:

    • Raise blood levels of folate[134,136]
    • Lower blood homocysteine levels by 14.6%[142]
    • Increase the folate content of red blood cells by 23%[142]
    • Improve depressive and anxious symptoms[143,144]
  • Vitamin B12 (as Methylcobalamin) – 6 mcg (250% DV)

    Methylcobalamin is our favorite form of B12 because it’s a methyl donor.[145]

    Your body needs B12 to make red blood cells, so lack of B12 can cause megaloblastic anemia, a condition in which red blood cells grow larger but less numerous, causing an overall decrease in aerobic capacity.[146,147]

    Vitamin B12 deficiency is also linked to high homocysteine and, in pregnant women, elevated risk of fetal birth defects.[148-150]

    EVen mild B12 deficiencies are linked to compromised memory performance,[151] partly because of B12’s effect on homocysteine.[152] But B12 is also needed for synthesizing S-adenosylmethionine (SAMe), which is essential for methylation, myelination, and phospholipid production in the central nervous system.[152]

    While studies have yet to prove that B12 can increase energy levels above baseline, fatigue is a common sign of early B12 deficiency,[153] and something best avoided.

  • Sodium (from sea salt) – 225 mg (10% DV)

    C4 Ultimate Strength Nutrition Facts

    Although salt has gotten a lot of bad press thanks to its sodium content, we should recognize that sodium is an essential electrolyte mineral that’s critical for muscle function, peak performance, and recovery.[154] Excessive sodium loss, say from sweating, can compromise these vital aspects of health,[155] so including a little sodium in a pre-workout isn’t necessarily a bad idea.

    If you’re worried about it, just sweat harder! Just kidding – if you have concerns about the sodium content here, ask your doctor.

    • Calcium – 75 mg (6% DV)

    • Phosphorus (as dipotassium phosphate) – 75 mg (6% DV)

    • Magnesium (as magnesium citrate) – 20 mg (5% DV)

    • Chloride (from Sea Salt) – 340 mg (15% DV)

    • Potassium (as dipotassium phosphate) – 190 mg (4% DV)

Flavors Available


    C4 2024

    The new 2024 C4 Series is here from Nutrabolt, with a new C4 formula, new pump ingredient named PeptiPump, and a total of 7 pre-workout supplements!

    This is one of the most impressive formulas we’ve seen in a very long time, and not just because it has the peptide double feature. The use of VELOX shows that someone at Nutrabolt really did their homework on maximizing the vasodilatory effect of citrulline and arginine. Plus, the nootropic blend here, with a dizzying array of niche alkaloids and ample neurotransmitter support, is absolutely top-notch.

    We love that the pre-workout includes a 5 gram total yield, but doesn’t ditch the creatine nitrate that C4’s become so well-known for. The only thing you’ll want to explore is another 1.25 grams of betaine somewhere, really.

    But again, the peptides are going to really push this over the edge into outstanding territory.

    To be honest, this formula would be a steal at almost any existing price point in the pre-workout category. A must try for 2024 and beyond.

    Cellucor C4 Ultimate Strength – Deals and Price Drop Alerts

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    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: PricePlow Staff

    PricePlow Staff

    PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

    The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

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    1. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    2. Morita, Masahiko, et al; “Oral Supplementation with a Combination of L-Citrulline and L-Arginine Rapidly Increases Plasma L-Arginine Concentration and Enhances NO Bioavailability.”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 7 Nov. 2014; https://www.ncbi.nlm.nih.gov/pubmed/25445598
    3. Ochiai, Masayuki, et al; “Short-Term Effects of L-Citrulline Supplementation on Arterial Stiffness in Middle-Aged Men.”; International Journal of Cardiology; U.S. National Library of Medicine; 8 Mar. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21067832
    4. Agarwal, Umang et al; “Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.”; The Journal of nutrition; vol. 147,4; 2017; 596-602; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368575/
    5. Bailey, Stephen J, et al; “l-Citrulline Supplementation Improves O2 Uptake Kinetics and High-Intensity Exercise Performance in Humans.”; Journal of Applied Physiology (Bethesda, Md. : 1985); U.S. National Library of Medicine; 15 Aug. 2015; https://www.ncbi.nlm.nih.gov/pubmed/26023227
    6. Ochiai, Masayuki, et al. “Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine”. United States Patent and Trademark Office. Patent US8609735B2. 17 Dec. 2013; https://patents.google.com/patent/US8609735B2/en
    7. Ochiai, Masayuki, et al. “Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine”. United States Patent and Trademark Office. Patent US9060980B2. 23 Jun. 2015; https://patents.google.com/patent/US9060980B2/en
    8. Ochiai, Masayuki, et al. “Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine”. United States Patent and Trademark Office. Patent US9622998B2. 18 Apr. 2017; https://patents.google.com/patent/US9622998B2/en
    9. Ochiai, Masayuki, et al. “Rapid-acting, blood-arginine-level-increasable oral preparation comprising citrulline and arginine”. United States Patent and Trademark Office. Patent US10052298B2. 21 Aug. 2018; https://patents.google.com/patent/US10052298B2/en
    10. Suzuki, Takashi, et al. “The Effects on Plasma L-Arginine Levels of Combined Oral L-Citrulline and L-Arginine Supplementation in Healthy Males.” Bioscience, Biotechnology, and Biochemistry, vol. 81, no. 2, 26 Sept. 2016, pp. 372–375, doi:10.1080/09168451.2016.1230007; https://academic.oup.com/bbb/article/81/2/372/5955995
    11. Suzuki, Izumi, et al. “A Combination of Oral L-Citrulline and L-Arginine Improved 10-Min Full-Power Cycling Test Performance in Male Collegiate Soccer Players: A Randomized Crossover Trial.” European Journal of Applied Physiology, vol. 119, no. 5, 16 Feb. 2019, pp. 1075–1084, doi:10.1007/s00421-019-04097-7 https://link.springer.com/article/10.1007/s00421-019-04097-7
    12. Morita, Masahiko, et al. “Oral Supplementation with a Combination of L-Citrulline and L-Arginine Rapidly Increases Plasma L-Arginine Concentration and Enhances NO Bioavailability.” Biochemical and Biophysical Research Communications, vol. 454, no. 1, Nov. 2014, pp. 53–57, 10.1016/j.bbrc.2014.10.029; https://www.sciencedirect.com/science/article/pii/S0006291X14018178
    13. El-Bassossy, Hany M et al. “Arginase inhibition alleviates hypertension associated with diabetes: effect on endothelial dependent relaxation and NO production.” Vascular pharmacology vol. 57,5-6 (2012): 194-200. doi:10.1016/j.vph.2012.01.001 https://www.sciencedirect.com/science/article/abs/pii/S1537189112000031
    14. Suzuki, Takashi et al. “Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.” Journal of the International Society of Sports Nutrition vol. 13 6. 19 Feb. 2016, doi:10.1186/s12970-016-0117-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759860/
    15. Pérez-Guisado, Joaquín, and Philip M Jakeman; “Citrulline Malate Enhances Athletic Anaerobic Performance and Relieves Muscle Soreness.”; Journal of Strength and Conditioning Research; U.S. National Library of Medicine; May 2010; https://www.ncbi.nlm.nih.gov/pubmed/20386132
    16. Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5. doi: 10.1016/j.bbrc.2014.12.005; https://pubmed.ncbi.nlm.nih.gov/25498545/
    17. Zhao, Guangfu et al. “Betaine in Inflammation: Mechanistic Aspects and Applications.” Frontiers in immunology vol. 9 1070. 24 May. 2018, doi:10.3389/fimmu.2018.01070 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976740/
    18. Craig, Stuart AS. “Betaine in Human Nutrition.” The American Journal of Clinical Nutrition, vol. 80, no. 3, 1 Sept. 2004, pp. 539–549, 10.1093/ajcn/80.3.539; https://www.sciencedirect.com/science/article/pii/S0002916522035602
    19. Ganguly, Paul, and Sreyoshi Fatima Alam. “Role of homocysteine in the development of cardiovascular disease.” Nutrition journal vol. 14 6. 10 Jan. 2015, doi:10.1186/1475-2891-14-6; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326479/
    20. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
    21. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[2]:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    22. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    23. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    24. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    25. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    26. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    27. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    28. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    29. Jason Michael Cholewa, et al; “The Effects of Chronic Betaine Supplementation on Body Composition and Performance in Collegiate Females: a Double-Blind, Randomized, Placebo Controlled Trial”; Journal of the International Society of Sports Nutrition; BioMed Central; 31 July 2018; https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0243-x
    30. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5; https://pubmed.ncbi.nlm.nih.gov/24760587/
    31. Hata, Y., et al. “A Placebo-Controlled Study of the Effect of Sour Milk on Blood Pressure in Hypertensive Subjects.” The American Journal of Clinical Nutrition, vol. 64, no. 5, 1 Nov. 1996, pp. 767–771, doi10.1093/ajcn/64.5.767; https://www.sciencedirect.com/science/article/pii/S0002916523174843
    32. Barbosa-Filho, José M., et al. “Natural Products Inhibitors of the Angiotensin Converting Enzyme (ACE): A Review between 1980 – 2000.” Revista Brasileira de Farmacognosia, vol. 16, no. 3, Sept. 2006, pp. 421–446, doi:10.1590/s0102-695×2006000300021; https://www.scielo.br/j/rbfar/a/hMzvKKXWfGcScLzH4fyTM8R/
    33. Michelke, Lydia, et al. “Effects of Bioactive Peptides Encrypted in Whey-, Soy- and Rice Protein on Local and Systemic Angiotensin-Converting Enzyme Activity.” Journal of Functional Foods, vol. 28, Jan. 2017, pp. 299–305, doi:10.1016/j.jff.2016.11.026; https://www.sciencedirect.com/science/article/abs/pii/S1756464616303814
    34. Vermeirssen, Vanessa, et al. “Bioavailability of Angiotensin I Converting Enzyme Inhibitory Peptides.” British Journal of Nutrition, vol. 92, no. 3, Sept. 2004, pp. 357–366, doi:10.1079/bjn20041189; https://pubmed.ncbi.nlm.nih.gov/15469639/
    35. Foltz, Martin, et al. “The Angiotensin Converting Enzyme Inhibitory Tripeptides Ile-Pro-pro and Val-Pro-pro Show Increasing Permeabilities with Increasing Physiological Relevance of Absorption Models.” Peptides, vol. 29, no. 8, Aug. 2008, pp. 1312–1320, doi:10.1016/j.peptides.2008.03.021; https://www.sciencedirect.com/science/article/abs/pii/S019697810800140X
    36. Amir Rezvankhah, et al. “Development of Lentil Peptides with Potent Antioxidant, Antihypertensive, and Antidiabetic Activities along with Umami Taste.” Food Science and Nutrition, vol. 11, no. 6, 27 Feb. 2023, pp. 2974–2989, doi:10.1002/fsn3.3279; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10261806/
    37. Mujika, I., and S. Padilla. “Creatine Supplementation as an Ergogenic Aid for Sports Performance in Highly Trained Athletes: A Critical Review.” International Journal of Sports Medicine, vol. 18, no. 07, Oct. 1997, pp. 491–496, 10.1055/s-2007-972670; https://www.ncbi.nlm.nih.gov/pubmed/9414070
    38. Terjung, RL, et al; “Physiological and Health Effects of Oral Creatine Supplementation.” Medicine & Science in Sports & Exercise, vol. 32, no. 3, Mar. 2000, pp. 706–717, 10.1097/00005768-200003000-00024; https://www.ncbi.nlm.nih.gov/pubmed/10731017
    39. Guzun, R., et al. “Systems Bioenergetics of Creatine Kinase Networks: Physiological Roles of Creatine and Phosphocreatine in Regulation of Cardiac Cell Function.” Amino Acids, vol. 40, no. 5, 10 Mar. 2011, pp. 1333–1348, 10.1007/s00726-011-0854-x; https://www.ncbi.nlm.nih.gov/pubmed/21390528
    40. Adhihetty, Peter J., and M. Flint Beal. “Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases.” NeuroMolecular Medicine, vol. 10, no. 4, 13 Nov. 2008, pp. 275–290, 10.1007/s12017-008-8053-y; https://www.ncbi.nlm.nih.gov/pubmed/19005780
    41. Stout JR, et al; “Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold”; J Strength & Cond Research; 2006 20(4): 928−931; https://www.ncbi.nlm.nih.gov/pubmed/17194255
    42. Branch, J David. “Effect of Creatine Supplementation on Body Composition and Performance: A Meta-Analysis.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 13, no. 2, 2003, pp. 198–226, 10.1123/ijsnem.13.2.198; https://pubmed.ncbi.nlm.nih.gov/12945830/
    43. Chilibeck, Philip, et al. “Effect of Creatine Supplementation during Resistance Training on Lean Tissue Mass and Muscular Strength in Older Adults: A Meta-Analysis.” Open Access Journal of Sports Medicine, vol. Volume 8, Nov. 2017, pp. 213–226, 10.2147/oajsm.s123529; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679696/
    44. Devries, Michael A, and Stuart M. Philips; “Creatine Supplementation during Resistance Training in Older Adults—a Meta-Analysis.” Medicine & Science in Sports & Exercise, vol. 46, no. 6, June 2014, pp. 1194–1203, 10.1249/mss.0000000000000220; https://pubmed.ncbi.nlm.nih.gov/24576864/
    45. Chilibeck, P. D., et al. “Creatine Monohydrate and Resistance Training Increase Bone Mineral Content and Density in Older Men.” The Journal of Nutrition, Health & Aging, vol. 9, no. 5, 2005, pp. 352–353; https://pubmed.ncbi.nlm.nih.gov/16222402/
    46. Candow, Darren G., et al. “Creatine Supplementation and Aging Musculoskeletal Health.” Endocrine, vol. 45, no. 3, 5 Nov. 2013, pp. 354–361, 10.1007/s12020-013-0070-4; https://pubmed.ncbi.nlm.nih.gov/24190049/
    47. Bogdanis, G C, et al. “Recovery of Power Output and Muscle Metabolites Following 30 S of Maximal Sprint Cycling in Man.” The Journal of Physiology, vol. 482, no. 2, 15 Jan. 1995, pp. 467–480, 10.1113/jphysiol.1995.sp020533; https://www.ncbi.nlm.nih.gov/pubmed/7714837
    48. Mendez-Villanueva, Alberto, et al. “The Recovery of Repeated-Sprint Exercise Is Associated with PCr Resynthesis, While Muscle PH and EMG Amplitude Remain Depressed.” PLoS ONE, vol. 7, no. 12, 17 Dec. 2012, p. e51977, 10.1371/journal.pone.0051977; https://www.ncbi.nlm.nih.gov/pubmed/23284836
    49. Mielgo-Ayuso, Juan, et al. “Effects of Creatine Supplementation on Athletic Performance in Soccer Players: A Systematic Review and Meta-Analysis.” Nutrients, vol. 11, no. 4, 31 Mar. 2019, p. 757, 10.3390/nu11040757; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520963/
    50. Lopez, Rebecca M et al. “Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses.” Journal of athletic training vol. 44,2 (2009): 215-23. doi:10.4085/1062-6050-44.2.215; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657025/
    51. Sakellaris, George, et al. “Prevention of Traumatic Headache, Dizziness and Fatigue with Creatine Administration. A Pilot Study.” Acta Paediatrica, vol. 97, no. 1, 3 Dec. 2007, pp. 31–34, 10.1111/j.1651-2227.2007.00529.x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583396/
    52. Schneider-Gold, C., et al. “Creatine Monohydrate in DM2/PROMM: A Double-Blind Placebo-Controlled Clinical Study.” Neurology, vol. 60, no. 3, 11 Feb. 2003, pp. 500–502, 10.1212/01.wnl.0000044405.29988.e1; https://pubmed.ncbi.nlm.nih.gov/12578937/
    53. McMorris, T., et al. “Effect of Creatine Supplementation and Sleep Deprivation, with Mild Exercise, on Cognitive and Psychomotor Performance, Mood State, and Plasma Concentrations of Catecholamines and Cortisol.” Psychopharmacology, vol. 185, no. 1, 17 Jan. 2006, pp. 93–103, 10.1007/s00213-005-0269-z; https://pubmed.ncbi.nlm.nih.gov/16416332/
    54. Fuld, J P. “Creatine Supplementation during Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease.” Thorax, vol. 60, no. 7, 1 July 2005, pp. 531–537, 10.1136/thx.2004.030452; https://pubmed.ncbi.nlm.nih.gov/15994258/
    55. Braegger, Christian P., et al. “Effects of Creatine Supplementation in Cystic Fibrosis: Results of a Pilot Study.” Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society, vol. 2, no. 4, 1 Dec. 2003, pp. 177–182; 10.1016/S1569-1993(03)00089-4; https://pubmed.ncbi.nlm.nih.gov/15463870/
    56. Bakian, Amanda V et al. “Dietary creatine intake and depression risk among U.S. adults.” Translational psychiatry vol. 10,1 52. 3 Feb. 2020, doi:10.1038/s41398-020-0741-x https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7026167/
    57. Rae, Caroline et al. “Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial.” Proceedings. Biological sciences vol. 270,1529 (2003): 2147-50. doi:10.1098/rspb.2003.2492; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/
    58. Benton, David, and Rachel Donohoe. “The Influence of Creatine Supplementation on the Cognitive Functioning of Vegetarians and Omnivores.” The British Journal of Nutrition, vol. 105, no. 7, 2011, pp. 1100–5, 10.1017/S0007114510004733; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/influence-of-creatine-supplementation-on-the-cognitive-functioning-of-vegetarians-and-omnivores/E2D37729902DDFA6CFC85767AD0421FC
    59. Schilling, Brian K., et al. “Creatine Supplementation and Health Variables: A Retrospective Study.” Medicine & Science in Sports & Exercise, vol. 33, no. 2, 2001, pp. 183–188; https://journals.lww.com/acsm-msse/Fulltext/2001/02000/Creatine_supplementation_and_health_variables__a.2.aspx
    60. Hoffman, Jay, et al. “Effect of Creatine and ß-Alanine Supplementation on Performance and Endocrine Responses in Strength/Power Athletes.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 16, no. 4, Aug. 2006, pp. 430–446, 10.1123/ijsnem.16.4.430; https://pubmed.ncbi.nlm.nih.gov/17136944/
    61. Cook, Christian J, et al. “Skill Execution and Sleep Deprivation: Effects of Acute Caffeine or Creatine Supplementation – a Randomized Placebo-Controlled Trial.” Journal of the International Society of Sports Nutrition, vol. 8, no. 1, 16 Feb. 2011, 10.1186/1550-2783-8-2; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049131/
    62. Volek, Jeff S., et al. “The Effects of Creatine Supplementation on Muscular Performance and Body Composition Responses to Short-Term Resistance Training Overreaching.” European Journal of Applied Physiology, vol. 91, no. 5-6, 1 May 2004, pp. 628–637, 10.1007/s00421-003-1031-z; https://pubmed.ncbi.nlm.nih.gov/14685870/
    63. Sheikholeslami Vatani, D., et al. “The Effects of Creatine Supplementation on Performance and Hormonal Response in Amateur Swimmers.” Science & Sports, vol. 26, no. 5, Nov. 2011, pp. 272–277, 10.1016/j.scispo.2011.07.003; https://www.sciencedirect.com/science/article/abs/pii/S0765159711001171
    64. Brosnan, John T., et al. “The Metabolic Burden of Creatine Synthesis.” Amino Acids, vol. 40, no. 5, 1 May 2011, pp. 1325–1331, 10.1007/s00726-011-0853-y; https://pubmed.ncbi.nlm.nih.gov/21387089/
    65. Cal R, Davis H, Kerr A, Wall A, Molloy B, Chauhan S, Trajkovic S, Holyer I, Adelfio A, Khaldi N. Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy. Nutrients. 2020; 12(8):2274; https://www.mdpi.com/2072-6643/12/8/2274/htm
    66. Hardy, Tabitha M, and Trygve O Tollefsbol. “Epigenetic diet: impact on the epigenome and cancer.” Epigenomics vol. 3,4 (2011): 503-18. doi:10.2217/epi.11.71; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3197720/
    67. Landecker, Hannah. “Food as exposure: Nutritional epigenetics and the new metabolism.” BioSocieties vol. 6,2 (2011): 167-194. doi:10.1057/biosoc.2011.1; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3500842/
    68. Jakubczyk, Anna, et al. “Peptides Obtained from Fermented Faba Bean Seeds (Vicia Faba) as Potential Inhibitors of an Enzyme Involved in the Pathogenesis of Metabolic Syndrome.” LWT, vol. 105, May 2019, pp. 306–313, https://www.sciencedirect.com/science/article/abs/pii/S002364381930091X
    69. Kerr, Alish et al. “Improved Strength Recovery and Reduced Fatigue with Suppressed Plasma Myostatin Following Supplementation of a Vicia faba Hydrolysate, in a Healthy Male Population.” Nutrients vol. 15,4 986. 16 Feb. 2023, doi:10.3390/nu15040986; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967853/
    70. Feiring, David C., et al. “Test-Retest Reliability of the Biodex Isokinetic Dynamometer.” Journal of Orthopaedic & Sports Physical Therapy, vol. 11, no. 7, Jan. 1990, pp. 298–300, doi:10.2519/jospt.1990.11.7.298; https://pubmed.ncbi.nlm.nih.gov/18796902/
    71. Valovich-mcLeod, Tamara C., et al. “Reliability and Validity of the Biodex System 3 pro Isokinetic Dynamometer Velocity, Torque and Position Measurements.” European Journal of Applied Physiology, vol. 91, no. 1, 1 Jan. 2004, pp. 22–29, doi:10.1007/s00421-003-0933-0; https://pubmed.ncbi.nlm.nih.gov/14508689/
    72. Weijzen, Michelle E. G., et al. “Vicia Faba Peptide Network Supplementation Does Not Differ from Milk Protein in Modulating Changes in Muscle Size during Short-Term Immobilization and Subsequent Remobilization, but Increases Muscle Protein Synthesis Rates during Remobilization in Healthy Young Men.” The Journal of Nutrition, vol. 153, no. 6, 1 June 2023, pp. 1718–1729; https://www.sciencedirect.com/science/article/pii/S0022316623025166
    73. Lundberg, Jon O., and Mirco Govoni. “Inorganic Nitrate Is a Possible Source for Systemic Generation of Nitric Oxide.” Free Radical Biology & Medicine, vol. 37, no. 3, 1 Aug. 2004, pp. 395–400, 10.1016/j.freeradbiomed.2004.04.027. https://pubmed.ncbi.nlm.nih.gov/15223073/
    74. Qu, X. M., et al. “From Nitrate to Nitric Oxide: The Role of Salivary Glands and Oral Bacteria.” Journal of Dental Research, vol. 95, no. 13, 1 Dec. 2016, pp. 1452–1456, 10.1177/0022034516673019; https://pubmed.ncbi.nlm.nih.gov/27872324/
    75. Eisenbrand, G., et al. “Nitrate and Nitrite in Saliva.” Oncology, vol. 37, no. 4, 1980, pp. 227–231, 10.1159/000225441; https://pubmed.ncbi.nlm.nih.gov/7443155/
    76. Larsen, F; “Effects of dietary nitrate on oxygen cost during exercise”; Department of Physiology and Pharmacology, Karolinska Institutet; 2007; https://pubmed.ncbi.nlm.nih.gov/17635415/
    77. Lansley, K; “Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study”; School of Sport and Health Sciences, Univ. of Exeter; 2011; https://journals.physiology.org/doi/full/10.1152/japplphysiol.01070.2010
    78. Bailey, S; “Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans”; School of Sport and Health Sciences, Univ. of Exeter; 2009; https://journals.physiology.org/doi/full/10.1152/japplphysiol.00722.2009
    79. Bescos, R; “Acute administration of inorganic nitrate reduces VO(2peak) in endurance athletes”; National Institute of Physical Education-Barcelona, University of Barcelona; 2011; https://pubmed.ncbi.nlm.nih.gov/21407132/
    80. Fulford, J; “Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions”; NIHR Exeter Clinical Research Facility, University of Exeter Medical School; 2013; https://pubmed.ncbi.nlm.nih.gov/23354414/
    81. Bailey, S; “Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans”; School of Sport and Health Sciences, University of Exeter; 2010; https://journals.physiology.org/doi/full/10.1152/japplphysiol.00046.2010
    82. Lundberg, J; “The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics”; Department of Physiology and Pharmacology, Karolinska Institute; 2008; https://www.nature.com/articles/nrd2466
    83. Larsen, F; “Dietary inorganic nitrate improves mitochondrial efficiency in humans”; Department of Physiology and Pharmacology, Karolinska Institutet; 2011; https://www.cell.com/cell-metabolism/fulltext/S1550-4131(11)00005-2
    84. Galvan, Elfego, et al. “Acute and Chronic Safety and Efficacy of Dose Dependent Creatine Nitrate Supplementation and Exercise Performance.” Journal of the International Society of Sports Nutrition, vol. 13, 2016, p. 12, 10.1186/s12970-016-0124-0; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4815124/
    85. Dalton, Ryan L., et al. “Hematological and Hemodynamic Responses to Acute and Short-Term Creatine Nitrate Supplementation.” Nutrients, vol. 9, no. 12, 15 Dec. 2017, 10.3390/nu9121359 https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5748809/
    86. Galvan, E., et al. “Effects of 28 Days of Two Creatine Nitrate Based Dietary Supplements on Bench Press Power in Recreationally Active Males.” Journal of the International Society of Sports Nutrition, vol. 12, no. Suppl 1, 2015, p. P17, 10.1186/1550-2783-12-S1-P17; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4595304/
    87. Joy, Jordan M, et al. “28 Days of Creatine Nitrate Supplementation Is Apparently Safe in Healthy Individuals.” Journal of the International Society of Sports Nutrition, vol. 11, no. 1, Dec. 2014, 10.1186/s12970-014-0060-9; https://jissn.biomedcentral.com/articles/10.1186/s12970-014-0060-9
    88. Joy, J. et al; “Supplementation with a Proprietary Blend of Ancient Peat and Apple Extract May Improve Body Composition without Affecting Hematology in Resistance-Trained Men;” Applied Physiology Nutrition and Metabolism; (2015); https://www.researchgate.net/publication/283077352_Supplementation_with_a_Proprietary_Blend_of_Ancient_Peat_and_Apple_Extract_May_Improve_Body_Composition_without_Affecting_Hematology_in_Resistance-Trained_Men
    89. Reyes-Izquierdo, T, et al; “Effect of Dietary Supplement ElevATP on Blood ATP Level: An Acute Pilot Clinical Study”; Journal of Aging Research & Clinical Practice; January 2013; https://www.researchgate.net/publication/260944038_Effect_of_the_dietary_supplement_ElevATP_on_blood_ATP_level_An_acute_pilot_clinical_study
    90. Joy JM et al., “Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men,” BMC Complementary and Alternative Medicine; 2016; https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1222-x
    91. Mishra, Akanksha, et al. “Physiological and Functional Basis of Dopamine Receptors and Their Role in Neurogenesis: Possible Implication for Parkinson’s Disease.” Journal of Experimental Neuroscience, vol. 12, Jan. 2018, p. 117906951877982, 10.1177/1179069518779829. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985548/
    92. Rajeev Dalal, and Dejan Grujic. “Epinephrine.” Nih.gov, StatPearls Publishing, 2 Apr. 2019. https://www.ncbi.nlm.nih.gov/books/NBK482160/
    93. Smith, Matthew D, and Christopher V Maani. “Norepinephrine.” Nih.gov, StatPearls Publishing, 23 July 2019. https://www.ncbi.nlm.nih.gov/books/NBK537259/
    94. Ans, Armghan H, et al. “Neurohormonal Regulation of Appetite and Its Relationship with Stress: A Mini Literature Review.” Cureus, 23 July 2018, 10.7759/cureus.3032. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150743/
    95. Mullur, Rashmi et al. “Thyroid hormone regulation of metabolism.” Physiological reviews vol. 94,2 (2014): 355-82. doi:10.1152/physrev.00030.2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044302/
    96. Rousset, Bernard. “Chapter 2 Thyroid Hormone Synthesis And Secretion.” Endotext. U.S. National Library of Medicine, 2 Sept. 2015; https://www.ncbi.nlm.nih.gov/books/NBK285550/
    97. Attipoe, Selasi, et al. “Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature.” Military Medicine, vol. 180, no. 7, July 2015, pp. 754–765, 10.7205/milmed-d-14-00594; https://academic.oup.com/milmed/article/180/7/754/4160625
    98. Pomeroy, Diane E., et al. “A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel.” Nutrients, vol. 12, no. 2, 20 Feb. 2020, p. 545, 10.3390/nu12020545; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071459/
    99. Ikeda-Murakami K, Tani N, Ikeda T, Aoki Y, Ishikawa T. Central Nervous System Stimulants Limit Caffeine Transport at the Blood-Cerebrospinal Fluid Barrier. Int J Mol Sci. 2022 Feb 7;23(3):1862. doi: 10.3390/ijms23031862. PMID: 35163784; PMCID: PMC8836437. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8836437/
    100. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010); https://link.springer.com/article/10.1186/1550-2783-7-5
    101. Cappelletti, Simone et al. “Caffeine: cognitive and physical performance enhancer or psychoactive drug?.” Current neuropharmacology vol. 13,1 (2015): 71-88. doi:10.2174/1570159X13666141210215655; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462044/
    102. Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170; https://www.sciencedirect.com/science/article/abs/pii/016501739290012B
    103. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance.”; J Int Soc Sports Nutr 7, 5 (2010); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7777221/
    104. Diepvens, K et al; “Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea;” American Journal of Physiology; 2007; https://journals.physiology.org/doi/full/10.1152/ajpregu.00832.2005
    105. Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008 Dec;33(6):1319-34. doi: 10.1139/H08-130; https://cdnsciencepub.com/doi/10.1139/H08-130
    106. Norager, C B, et al; “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.”; Clinical Endocrinology; U.S. National Library of Medicine; Aug. 2006; https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2006.02579.x
    107. Collado-Mateo D, Lavín-Pérez AM, Merellano-Navarro E, Coso JD. Effect of Acute Caffeine Intake on the Fat Oxidation Rate during Exercise: A Systematic Review and Meta-Analysis. Nutrients. 2020 Nov 24;12(12):3603. doi: 10.3390/nu12123603. PMID: 33255240; PMCID: PMC7760526. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760526/
    108. Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS. Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. 2017 Jul;20(6):369-377. doi: 10.1080/1028415X.2016.1144845; https://www.tandfonline.com/doi/abs/10.1080/1028415X.2016.1144845
    109. McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine’s effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016 Dec;71:294-312. doi: 10.1016/j.neubiorev.2016.09.001; https://www.sciencedirect.com/science/article/pii/S0149763416300690
    110. Klaassen EB, de Groot RH, Evers EA, Snel J, Veerman EC, Ligtenberg AJ, Jolles J, Veltman DJ. The effect of caffeine on working memory load-related brain activation in middle-aged males. Neuropharmacology. 2013 Jan;64:160-7. doi: 10.1016/j.neuropharm.2012.06.026; https://www.sciencedirect.com/science/article/abs/pii/S0028390812002845
    111. Roberto, Mike; “Dynamine: A Neuroactivating “Stimulant” by Compound Solutions”; The PricePlow Blog; Feb. 5, 2018; https://blog.priceplow.com/supplement-ingredients/dynamine
    112. Roberto, Mike; “Dynamine Achieves GRAS Status With Several New Safety Studies!”; The PricePlow Blog; July 5, 2019; https://blog.priceplow.com/dynamine/gras
    113. Murbach, TS et al; “A Toxicological Evaluation of Methylliberine (Dynamine®)”; Journal of Toxicology; 2019; https://www.hindawi.com/journals/jt/2019/4981420/
    114. VanDusseldorp, TA et al; “Effect of Dynamine® With and Without TeaCrine® Over Four Weeks of Continuous Use on Cardiovascular Function and Psychometric Parameters of Healthy Males and Females”; Nutrients; 2020; https://www.researchgate.net/publication/339655396_Safety_of_Short-Term_Supplementation_with_Methylliberine_DynamineR_Alone_and_in_Combination_with_TeaCrineR_in_Young_Adults
    115. Feduccia, Allison A., et al. “Locomotor Activation by Theacrine, a Purine Alkaloid Structurally Similar to Caffeine: Involvement of Adenosine and Dopamine Receptors.” Pharmacology, Biochemistry, and Behavior, vol. 102, no. 2, 1 Aug. 2012, pp. 241–248, 10.1016/j.pbb.2012.04.014; https://pubmed.ncbi.nlm.nih.gov/22579816/
    116. Li, Wei-Xi et al. “Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.” Journal of agricultural and food chemistry vol. 61,26 (2013): 6328-35. doi:10.1021/jf400982c https://pubs.acs.org/doi/10.1021/jf400982c
    117. Qiao, Haoyi, et al. “Theacrine: A Purine Alkaloid from Camellia Assamica Var. Kucha with a Hypnotic Property via the Adenosine System.” Neuroscience Letters, vol. 659, 17 Oct. 2017, pp. 48–53, 10.1016/j.neulet.2017.08.063; https://pubmed.ncbi.nlm.nih.gov/28864241/
    118. Sheng, Yue-Yue et al. “Theacrine From Camellia kucha and Its Health Beneficial Effects.” Frontiers in nutrition vol. 7 596823. 17 Dec. 2020, doi:10.3389/fnut.2020.596823 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773691/
    119. Feduccia, Allison A et al. “Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.” Pharmacology, biochemistry, and behavior vol. 102,2 (2012): 241-8. doi:10.1016/j.pbb.2012.04.014 https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(12)00124-4
    120. Bello, M.L., Walker, A.J., McFadden, B.A. et al. “The effects of TeaCrine® and caffeine on endurance and cognitive performance during a simulated match in high-level soccer players”;J Int Soc Sports Nutr 16, 20 (2019); https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6472067/
    121. Cintineo, Harry P., et al. “Effects of Caffeine, Methylliberine, and Theacrine on Vigilance, Marksmanship, and Hemodynamic Responses in Tactical Personnel: A Double-Blind, Randomized, Placebo-Controlled Trial.” Journal of the International Society of Sports Nutrition, vol. 19, no. 1, 18 Aug. 2022, pp. 543–564, doi:10.1080/15502783.2022.2113339; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9397462/
    122. Tartar, Jaime L, et al. “A Combination of Caffeine, TeaCrine® (Theacrine), and Dynamine® (Methylliberine) Increases Cognitive Performance and Reaction Time without Interfering with Mood in Adult Male Egamers.” Cureus, 20 Dec. 2021, doi:10.7759/cureus.20534; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768451/
    123. La Monica, Michael B., et al. “Effects of TeaCrine® (theacrine), Dynamine™ (methylliberine), and caffeine on gamer psychomotor performance in a first-person shooter video game scenario”. bioRxiv Pre-Print. 22 Apr 2021. https://www.biorxiv.org/content/10.1101/2021.04.21.440794v1
    124. Zhao, Qin, and Xi Can Tang. “Effects of Huperzine a on Acetylcholinesterase Isoforms in Vitro: Comparison with Tacrine, Donepezil, Rivastigmine and Physostigmine.” European Journal of Pharmacology, vol. 455, no. 2-3, 29 Nov. 2002, pp. 101–107, 10.1016/s0014-2999(02)02589-x. https://pubmed.ncbi.nlm.nih.gov/12445575/
    125. Purves D, Augustine GJ, Fitzpatrick D, et al.; “Neuroscience;” 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Acetylcholine. https://www.ncbi.nlm.nih.gov/books/NBK11143/
    126. Hasselmo ME; “The role of acetylcholine in learning and memory;”Curr Opin Neurobiol. 2006;16(6):710–715; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659740/
    127. Jones BE; “From waking to sleeping: neuronal and chemical substrates”. Trends Pharmacol. Sci.; 2005; 26 (11): 578–86; https://www.ncbi.nlm.nih.gov/pubmed/16183137
    128. Ma, Tuo, et al. “Huperzine a Promotes Hippocampal Neurogenesis in Vitro and in Vivo.” Brain Research, vol. 1506, 19 Apr. 2013, pp. 35–43, 10.1016/j.brainres.2013.02.026. https://www.ncbi.nlm.nih.gov/pubmed/23454433
    129. Perry BD, U’Prichard DC; European Journal of Pharmacology; “(3H)rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors;”1981; https://www.ncbi.nlm.nih.gov/pubmed/6276200
    130. Lafontan, M., et al. “Alpha-2 Adrenoceptors in Lipolysis: Alpha 2 Antagonists and Lipid-Mobilizing Strategies.” The American Journal of Clinical Nutrition, vol. 55, no. 1 Suppl, 1 Jan. 1992, pp. 219S227S, 10.1093/ajcn/55.1.219s; https://pubmed.ncbi.nlm.nih.gov/1345885/
    131. Callahan, Michael F., et al. “Yohimbine and Rauwolscine Reduce Food Intake of Genetically Obese (Obob) and Lean Mice.” Pharmacology Biochemistry and Behavior, vol. 20, no. 4, Apr. 1984, pp. 591–599, 10.1016/0091-3057(84)90309-5; https://pubmed.ncbi.nlm.nih.gov/6145164/
    132. Mizuki, Y., et al. “Differential Effects of Noradrenergic Drugs on Anxiety and Arousal in Healthy Volunteers with High and Low Anxiety.” Progress in Neuro-Psychopharmacology & Biological Psychiatry, vol. 20, no. 8, 1 Nov. 1996, pp. 1353–1367, 10.1016/s0278-5846(96)00131-5; https://pubmed.ncbi.nlm.nih.gov/9004342/
    133. National Institutes of Health. “Vitamin B6 – Fact Sheet For Health Professionals.” Office of Dietary Supplements; https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/
    134. Prinz-Langenohl, R et al; “[6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C–>T polymorphism of methylenetetrahydrofolate reductase.”; British journal of pharmacology; vol. 158,8; 2009; 2014-21; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2807663/
    135. Pietrzik, Klaus, et al; “Folic Acid and L-5-Methyltetrahydrofolate: Comparison of Clinical Pharmacokinetics and Pharmacodynamics.”; Clinical Pharmacokinetics; U.S. National Library of Medicine; Aug. 2010; https://www.ncbi.nlm.nih.gov/pubmed/20608755
    136. Knowles, L et al. “Treatment with Mefolinate (5-Methyltetrahydrofolate), but Not Folic Acid or Folinic Acid, Leads to Measurable 5-Methyltetrahydrofolate in Cerebrospinal Fluid in Methylenetetrahydrofolate Reductase Deficiency.” JIMD reports vol. 29 (2016): 103-107. doi:10.1007/8904_2016_529 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059208/
    137. Wierzbicki, Anthony S; “Homocysteine and Cardiovascular Disease: a Review of the Evidence.”; Diabetes & Vascular Disease Research; U.S. National Library of Medicine; June 2007; https://www.ncbi.nlm.nih.gov/pubmed/17654449
    138. Casas, J P, et al; “Homocysteine and Stroke: Evidence on a Causal Link from Mendelian Randomisation.”; Lancet (London, England);, U.S. National Library of Medicine; https://www.ncbi.nlm.nih.gov/pubmed/15652605
    139. Czeizel, Andrew E et al; “Folate deficiency and folic acid supplementation: the prevention of neural-tube defects and congenital heart defects.”; Nutrients; vol. 5,11; 4760-75; 21 Nov. 2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3847759/
    140. Choi, Sang-Woon, and Joel B Mason; “Folate Status: Effects on Pathways of Colorectal Carcinogenesis.”; The Journal of Nutrition; U.S. National Library of Medicine; Aug. 2002; https://www.ncbi.nlm.nih.gov/pubmed/12163703
    141. Chita, Dana Simona et al. “MTHFR Gene Polymorphisms Prevalence and Cardiovascular Risk Factors Involved in Cardioembolic Stroke Type and Severity.” Brain sciences vol. 10,8 476. 24 Jul. 2020, doi:10.3390/brainsci10080476 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463445/
    142. Venn, Bernard J, et al; “Comparison of the Effect of Low-Dose Supplementation with L-5-Methyltetrahydrofolate or Folic Acid on Plasma Homocysteine: a Randomized Placebo-Controlled Study.”; The American Journal of Clinical Nutrition; U.S. National Library of Medicine; Mar. 2003; https://www.ncbi.nlm.nih.gov/pubmed/12600857
    143. Shelton, Richard C et al; “Assessing Effects of l-Methylfolate in Depression Management: Results of a Real-World Patient Experience Trial.”; The primary care companion for CNS disorders; vol. 15,4; 2013; PCC.13m01520; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3869616/
    144. Anderson, Shanna et al; “Anxiety and Methylenetetrahydrofolate Reductase Mutation Treated With S-Adenosyl Methionine and Methylated B Vitamins.”; Integrative medicine (Encinitas, Calif.); vol. 15,2; 2016; 48-52; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898281/
    145. Shorter KR, Felder MR, Vrana PB. Consequences of dietary methyl donor supplements: Is more always better? Prog Biophys Mol Biol. 2015 Jul;118(1-2):14-20. doi: 10.1016/j.pbiomolbio.2015.03.007. Epub 2015 Apr 2. PMID: 25841986. https://linkinghub.elsevier.com/retrieve/pii/S0079-6107(15)00043-7
    146. da Silva, Weslay Rodrigues et al. “Recognition and management of vitamin B12 deficiency: Report of four cases with oral manifestations.” Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry vol. 42,4 (2022): 410-415. doi:10.1111/scd.12685 https://onlinelibrary.wiley.com/doi/10.1111/scd.12685
    147. Langan, Robert C, and Andrew J Goodbred. “Vitamin B12 Deficiency: Recognition and Management.” American family physician vol. 96,6 (2017): 384-389. https://www.aafp.org/pubs/afp/issues/2017/0915/p384.html
    148. Wahbeh, Farah, and Mange Manyama. “The role of Vitamin B12 and genetic risk factors in the etiology of neural tube defects: A systematic review.” International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience vol. 81,5 (2021): 386-406. doi:10.1002/jdn.10113 https://onlinelibrary.wiley.com/doi/10.1002/jdn.10113
    149. Rogne, Tormod et al. “Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data.” American journal of epidemiology vol. 185,3 (2017): 212-223. doi:10.1093/aje/kww212 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390862/
    150. ‌Bala, Renu et al. “Hyperhomocysteinemia and low vitamin B12 are associated with the risk of early pregnancy loss: A clinical study and meta-analyses.” Nutrition research (New York, N.Y.) vol. 91 (2021): 57-66. doi:10.1016/j.nutres.2021.05.002 https://linkinghub.elsevier.com/retrieve/pii/S0271-5317(21)00023-3
    151. Köbe, Theresa et al. “Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment.” The American journal of clinical nutrition vol. 103,4 (2016): 1045-54. doi:10.3945/ajcn.115.116970 https://www.sciencedirect.com/science/article/pii/S0002916523119289
    152. Gröber, Uwe et al. “Neuroenhancement with vitamin B12-underestimated neurological significance.” Nutrients vol. 5,12 5031-45. 12 Dec. 2013, doi:10.3390/nu5125031 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875920/
    153. Ankar, Alex, and Anil Kumar. “Vitamin B12 Deficiency (Cobalamin).” Nih.gov, StatPearls Publishing, 2019, www.ncbi.nlm.nih.gov/books/NBK441923/
    154. Strazzullo P., Leclercq C.; “Sodium.” Advanced Nutrition; March 2014; 5(2) 188-190; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951800/
    155. Valentine, V. 2007. “The Importance of Salt in the Athlete’s Diet.” Current Sports Medicine Reports vol. 6,4 (2007): 237-40. https://pubmed.ncbi.nlm.nih.gov/17617999/

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