Nutrex has been one of the most aggressive companies in the fat burner market in the last few years, releasing new products almost as soon as effective new ingredients are tested in studies. They’ve also been rewarded for it, as pretty much everything so far in their Lipo 6 series has sold really well.
Lipo 6 RX is going to be their first fat burner since Adipodex, and of course AMP Citrate is off the menu, but it looks like theacrine is going to be the new centerpiece ingredient.
The long story short is that Lipo-6 RX should provide a long-lasting effect due to the theacrine, hordenine, and dicaffeine malate added to the regular caffeine. Read why below after signing up for price updates:
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Lipo 6 RX Ingredients
Nutrex didn’t simply increase doses of ingredients in Lipo-6 Ultra Concentrate, they went back to square one and started from scratch, crafting a rather unique formula included some ingredients we haven’t seen in many fat loss supplements before:
Theacrine: Caffeine+ (100mg)
Theacrine is very similar to caffeine in chemical structure, and naturally has very similar effects. The difference is that the body doesn’t appear to build a tolerance to it the same way that it does with caffeine, so escalating doses aren’t necessary to keep getting the same effect. It also appears to reduce oxidative stress on the body when taken for at least seven days.
It’s been used in a few other products already, and you might have seen it under the trade names TeaCor or TeaCrine (which are proprietary compounds, the latter of which appears to be the one in Lipo 6 RX). The science on it is still definitely preliminary, but it’s very exciting as a new longer-lasting “showpiece” stimulant for products.
In addition to the energy benefit, there’s one study out that indicates it elevates dopamine levels in the brain, making it a potent potential mood enhancer as well.
What About Fat Burn?
Energy and mood are all well and good, but what about adipose activation? Well … that’s where we hit a wall, at least for now. Nutrex hasn’t dropped a label, and we don’t know any other ingredients as of yet. All the other information we have is that it’ll be 60 caps to a bottle, with a recommended dose of two caps per day.
Adipodex was centered around Yohimbine (with some Bioperine to improve absorption), however, and we’d guess they’re going to stick with it. It’s pretty well tried and battle-tested at this point, and it’s extremely popular in fat-burning products.
Now, on to the rest of the players in this fat-incinerating matrix!
DMAE Bitartrate (150mg)
DMAE is a choline derivative that contains one less methyl group. It helps fight the buildup of the “age pigment” in the brain. Additionally, it also increases the production of acetylcholine. The perks of this is an improvement in cognition in memory.
Anecdotally, 200mg seems to be the “sweet spot” for many users. As this is at 150mg, it may be hit or miss for some. As to what it’s doing in a fat burner, we’re not entirely sure…
Along with the theacrine and caffeine (which we get to next!), N-Acetyl-L-Tyrosine (NALT) are the heavy “energy” components of Lipo-6 Rx. L-Tyrosine is a well-known focus booster and fatigue reducer, and NALT is the “better,” more bioavailable variant.
NALT increases the production of dopamine and noradrenaline, two important neurotransmitters in the brain. Its included due to its ability to improve mood, while alleviating stress.[5,6] We only have to question if this dose is enough as most effective doses have been several times higher than the 100mg included here.
Caffeine Anhydrous (100mg)
If you have a fat burner, you’re going to have caffeine. The two go together like peas and carrots or red beans and rice. We won’t take up too much space explaining its purpose in Lipo-6 Rx, but here are a few of its noteworthy contributions:
- Boost metabolism
- Stimulate lipolysis (fat-burning)
- Increase energy
- Improve mood
However, we’ve only covered the first of TWO forms of caffeine, which leads us to…
Infinergy™ Dicaffeine Malate (100mg)
Developed by Creative Compounds, Dicaffeine Malate is the combination of caffeine and malic acid. The main advantage of this is the malate component buffers the stomach from the effects of caffeine. This should help smooth out any potential discomfort or upset that pure caffeine anhydrous may cause. Malic acid is also suggested to help restore the energy produced from the ingestion of caffeine.
More and more companies are starting to use the combo of caffeine anhydrous and Infinergy. The reasoning for this is that dicaffeine malate doesn’t give enough of an initial surge of energy, but too much caffeine anhydrous can leave some feeling jittery and having that dreaded caffeine crash.
By combining the two, you still get the hard “kick” from anhydrous initially and then have Infinergy to smooth out the ride and give it a longer stim effect. This will give a prolonged sense of energy without any crash or drowsiness when the anhydrous wears off.
Hordenine HCl (50mg)
Hordenine is a component of Citrus Aurantium, a.k.a. Bitter Orange, which also contains other adrenergic amines, tyramine and synephrine. Similar to tyramine, Hordenine is a beta-2 adrenergic agonist, which boosts the production of adrenaline and noradrenaline. This will boost your heart rate and breathing rate, which will increase your body’s metabolic output, leading to more fat-burning effects!
Ginger Root CO2 Extract (20mg)
Ginger is a root that has traditionally been used in Chinese and Ayurvedic medicine for its ability to ease a number of stomach related ailments, from constipation to nause to indigestion.[10,11] So including it in a fat burner, where you’re taking in a larger amount of stims, makes sense to help offset any potential stomach upset.
However, ginger has also been found to increase the thermic effect of food and reduce appetite. The means you’ll be burning more calories eating food and not be inclined to have those ravenous cravings that so often can occur when going on a fat-loss diet.
Rauwolscine is a source of yohimbine extracted for alpha yohimbine. It is a much stronger version of yohimbine, hence the small dose. When paired with all of the other fat loss agents in Lipo-6 Rx, you should see superior fat loss and appetite suppression.
Rauwolscine is an alpha-2 adrenergic agonist and that helps accelerate fat loss. Now, it doesn’t directly burn fat, but it inhibits the receptors in your body that inhibit fat loss. By blocking these receptors, Rauwolscine enhances the fat-burning effectiveness of the other ingredients included in Lipo-6 Rx.
Each bottle of fat shredding goodness contains 60 liquid capsules. At the maximum dosage, this will last you 30 days with 1 capsule being taken in the morning and one in the evening. Be forewarned, that this is A LOT of stims and it’s probably best to avoid other sources of caffeine if you are sensitive to its effects or have trouble sleeping.
Nutrex went back to the drawing board and came up with a rather multi-faceted fat burner. Not only will you have increased energy and alertness, you’ll also have improved focus, mood and appetite suppression.
Ultimately, we like the Theacrine + Caffeine + Infinergy blend — this is going to be a lot longer-lasting fat burner than what you’re used to with the old standard Lipo-6’s.
So if you used Lipo-6 in the past, but thought that the surge ended too quickly, you’re going to have to try this one – it will undoubtedly outlast the original.
Lipo-6 Rx is a big change from Adipodex which was centered around AMP Citrate. While there is no more AMP, we get a well-rounded blend of stims and lipolytic agents that will accelerate your fat loss efforts and get you on your way to your physique ideals!
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- Li WX, et al.; “Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.“; J Agric Food Chem.; 2013
- Feduccia A, et al.; “Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.”; Pharmacol Biochem Behav; 2012
- Ostojic, SM; “Yohimbine: the effects on body composition and exercise performance in soccer players“; Research in Sports Medicine; October-December 2006
- Callahan, MF, et. al; “Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice“; Pharmacology, Biochemistry and Behavior; April 1984
- Deijen, JB, et. al; “Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course“; Brain Research Bulletin; January 1999
- Magnusson, I, et. al; “N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans“; Metabolism; October 1989
- Frank M, et al; Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse; Equine Vet J. (1990)
- Mansour MS, et al; Ginger consumption enhances the thermic effect of food and promotes feelings of satiety without affecting metabolic and hormonal parameters in overweight men: A pilot study . Metabolism. (2012)
- Mowrey DB, Clayson DE; Motion sickness, ginger, and psychophysics . Lancet. (1982)
- Lohsiriwat S, et al Effect of ginger on lower esophageal sphincter pressure . J Med Assoc Thai. (2010)
- Perry BD, U’Prichard DC; (3H)rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors . Eur J Pharmacol. (1981)
- Nagy I, Nagy K; On the role of cross-linking of cellular proteins in aging . Mech Ageing Dev. (1980)