VMI Sports White Heat: High Caffeine High Heat Fat Burner

VMI Sports has quietly been staking their claim on several parts of the supplement market – they’ve always been known for their high-stimulant K-XR pre workout, which uses a triple-stage caffeine threat that is not for the timid. But more recently, their Protolyte whey protein isolate powder (now with over half a dozen insanely underrated flavors) has caught everyone’s attention.

VMI Sports White Heat

Whatever happened to high-caffeine fat burners that worked beyond energy?! It’s here from the brand behind K-XR with VMI Sports White Heat!

Yet while they’ve always had great carnitine supplements (both with and without “heat”), the brand has never had a capsule based fat burner – until June 2021!

VMI Sports White Heat: The K-XR of Fat Burners

In true style of the brand behind K-XR, VMI Sports has released a high-caffeine fat burner named White Heat, and once again, it’s not for the timid. Inside, you’ll get 400mg caffeine from three different forms — most of it time-released — and that comes in a two capsule serving.

400mg caffeine in two caps!

This means you’re either going moderately hard, or all-in. White Heat is amplified with additional energy from theacrine and alpha yohimbine, so you know that this is going to perk you up for a long time, and then some. Good news is that it’s smoothed out with a couple relaxing ingredients in L-theanine and bacopa monnieri, a vastly underrated feel-good combination.

VMI Sports Logo

VMI Sports finally has a capsule-based fat burner, and it’s intense!

The heat in White Heat comes from grains of paradise and sweat-inducing GBB (along with the hefty hit of caffeine), and there’s added ingredients like fucoxanthin making this quite a diverse fat burner in just two capsules.

Caffeine lovers have been slightly abandoned by fat burners lately, so White Heat is the option if you want it strong. The analysis is below, but first check out our prices and sign up for VMI Sports news alerts:

VMI Sports White Heat - Ultra Burn – Deals and Price Drop Alerts

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VMI Sports White Heat Ingredients

In just two capsules, you get the following high-energy profile:

  • Caffeine Blend (yielding 400mg total caffeine)

    • Dicaffeine Malate (Infinergy) – 300mg (yielding ~220mg caffeine)

    • Caffeine Anhydrous – 130mg

    • Caffeine Citrate – 100mg (yielding 50mg caffeine)

    VMI Sports White Heat Ingredients

    Three forms of caffeine totaling 400 milligrams in just two capsules. Are you ready to burn fat with intensity?!

    Look out! It’s a high-caffeine fat burner, made of the trifecta blend of dicaffeine malate (slower), caffeine anhydrous (regular), and caffeine citrate (anecdotally faster).

    It’s not unusual to see high-caffeine pre workouts, and VMI Sports is well known for one of their own in K-XR, which uses the same three forms. Lately, however, the industry has stayed away from fat burners with this much caffeine. But let’s face it – some of us want it at warp speed!

    And with just two capsules, you don’t have much choice – you’re either going in at the beginner single capsule dose at 200mg, or you’re going full-tilt with 400 milligrams. Realize, however, that we have mostly dicaffeine malate, so this will be a strong time-released flow, and not as up-front and aggressive as 400 milligrams of caffeine anhydrous alone would be.

    Let’s talk about what caffeine does, and then differentiate between these three sources.

    How caffeine works

    As most know, caffeine wakes you up, additionally helping with increased fat oxidation and cognition, providing more mental and physical energy. It does this by inhibiting adenosine, which is a neurotransmitter that drives relaxation and sleep.[1] By turning down adenosine, we get increased alertness, and studies have shown that caffeine also decreases appetite and increases thermogenic heat[1,2] — hence our White Heat.

    Going further, caffeine consistently stimulates cyclic AMP (also known as cAMP or cyclic adenosine monophosphate) by inhibiting another enzyme in phosphodiesterase in both fat and muscle tissues. The end result is that you get more thermogenesis, helping the body expend more energy.[2,3]

    The three forms of caffeine in White Heat

    What’s great about this blend is that it’s not just a 400mg strike all at once – a great deal of it comes in the form of delayed release caffeine:

    Caffeine D2 / D3 Receptor

    Awaken! This graphic shows caffeine’s effects on wakefulness.

    • Infinergy dicaffeine malate provides the majority of the caffeine, at 220mg worth (we have 300mg total, but it’s ~73% caffeine by weight, as it’s bonded to malic acid). This takes your body a bit longer to break down, smoothing out the “caffeine curve”.
    • Caffeine anhydrous is simply caffeine without water — this is the standard caffeine we’re used to seeing in supplements. There’s 130mg anhydrous here.
    • Caffeine Citrate is instead blended with citric acid, and we get 50mg total here (it’s ~50% caffeine by weight). Anecdotally speaking, this is a faster-acting form of caffeine.

    What’s unique is that we have more dicaffeine malate than anhydrous here – so the majority of the energy is going to come slowly, although the fast forms are nothing to sneeze at!

    While we need more than just caffeine to enhance fat oxidation, this will definitely get fatty acid turnover started, and shows exactly what VMI Sports is thinking here.

    Not everyone goes this high of caffeine, but for those who do… the market is no longer neglecting you! But don’t worry – next we smooth the ride out:

  • Bacopa Extract (20% Bacosides) (Bacopa monnieri L.) (leaf) extract – 115mg

    Bacopa Monnieri

    Bacopa Monnieri has been coming on strong as a relaxing brain booster, which it’s great at. But in terms of sleep, it’s a bit of a shot in the dark. Image courtesy Wikimedia

    To balance out the huge dosage of caffeine, we need a couple of strong anxiolytics that will feel good and reduce cortisol, which may promote some fat loss effects in their own way.

    Bacopa monnieri is a popular traditional herb that’s been used as an adaptogen for quite some time. It’s able to regulate dopamine, serotonin, acetylcholine, and GABA — several critical neurotransmitters — in the brain.[4,5] It’s all driven by the bacosides inside,[6] which are the adaptogenic regulators that not only help us feel good, but can regenerate synapses and repair injured neurons![5]

    Due to the functions listed above, you can get a lot of great effects from bacopa (most of which are cognitive or mental):

    • Reduced stress and lower cortisol[7,8]
    • Improved memory and cognition[9]
    • Anxiety relief[10-14]
    • Better learning capabilities[4,15-19]
    • Protection from neurodegeneration[20,21]

    These are all great, especially paired up with a high-stim fat burner… but in terms of weight loss, it’s the cortisol we need to focus on. So next let’s discuss chronic cortisol’s nasty effects, then get to how bacopa can help alleviate it:

    Chronic cortisol and weight gain

    Bacopa helps alleviate stress and anxiety by significantly reducing cortisol levels in the body.[7]

    Cortisol is known as the “stress hormone”, and serves a great purpose, preparing the brain and body for taxing situations where we may need to preserve energy and “get on edge” for whatever scenario is stressing us. The issue is when we have chronically high cortisol levels, which is all too often in our stressful society. When cortisol levels don’t go down ever, we experience the following health consequences:

    • Higher blood glucose levels,[22]
    • Increased abdominal fat / difficulty losing fat,[23]
    • Lower muscle mass and strength,[24] and
    • Uncontrolled appetite.[25]

    This isn’t always a bad thing in the short term – it’s great that our bodies can keep blood sugar high for immediate use. But when it’s always high, we have ourselves a major problem. Chronic cortisol leads to a “downward spiral” that becomes difficult to escape, as the poor health may further stress us out!

    Bacopa: underrated cortisol reducer

    Bacopa Monnieri

    Bacopa is a perennial flowering plant frequently used for its mood-enhancing qualities, but it’s also an incredibly powerful nootropic for learning and memory.

    Bacopa helps, however. Several studies have shown that it lowers cortisol,[7,8] helping you to get focused and back to work. It’s the bacoside content that’s doing the job, which we have disclosed here from VMI Sports.

    This ingredient is not seen often enough in sports nutrition. There’s been a shift to powdered based supplements, and the ingredient does not taste good. So the best chance to get it in is through capsule form, and VMI was wise to add it. They’re even more wise to pair it with L-theanine next, which will also ease the strike from caffeine, but with an entirely different mechanism.

    Together, this could be one of the better-feeling high-caffeine products because of the effects of these two ingredients – and when we feel good and less stressed, we generally eat less.

  • L-Theanine – 100mg

    With a similar function to bacopa monnieri, L-theanine also takes some of the edge off of the high hit of caffeine, leading to cognitive benefits driven by its synergy with caffeine.[26-28]

    L-theanine is found in tea leaves (camellia sinensis), and helps the body produce more GABA, a neurotransmitter related to relaxation. Research studies have shown that it has a non-sedative, relaxing feel, and in doses between 50 and 200 milligrams (right where we’re at), there is increased alpha-wave activity in the brain after just 40 minutes.[29]

    L-Theanine Tea

    L-Theanine comes from tea leaves, and pairs very well with caffeine offset any potential anxiety.

    Before White Heat, we’ve never combined L-theanine and bacopa together, and definitely expect them to enhance the focus and cognitive effect while also lessening any crash (which should already be alleviated by the dicaffeine malate based blend).

  • Theacrine (as Teacrine 40%) – 100mg

    Is 400mg of long-lasting caffeine not enough for you? Here’s even more high-half-life cognitive power. Theacrine has been added to provide another level of neurostimulatory action in White Heat. This ingredient is an alkaloid found in kucha tea leaves, and research has shown that it can boost energy, mood, physical performance, and cognition.[30,31]

    Even better? Theacrine is synergistic with its chemical cousin, caffeine,[30,31] which you know we have here in spades!

    The function is actually similar to caffeine, in that it blocks adenosine receptors. But what’s impressive is that it can also activate dopamine receptors,[30,31] enhancing cognition – and it lasts quite a while! But the best part is that it doesn’t seem to affect the cardiovascular system or increase blood pressure like caffeine does.[30]

    VMI was clearly not kidding when they wanted to bring a long-lasting fat burner to the field. This is probably one you don’t want to take too late in the day at all — possibly 2pm at the latest!


    Want longer-lasting energy? Here it is. Effect Size of 200 mg dose of Teacrine over course of 7-day repeated dose study relative to baseline on: Energy: 0.63, Motivation to Exercise: 0.58, Concentration: 0.6

  • Green tea extract (50% EGCG) (Camellia Sinensis) (leaf) – 50mg

    We’ve recently begun calling green tea extract a “metabolic catch-all”, a phrase we stand behind because of its numerous beneficial health effects.

    While this isn’t a monstrous dosage, green tea extract has been shown to yield the following benefits with regards to human metabolism:

    • Increased fat oxidation and decreased fat mass[32]
    • Better blood flow[33]
    • Improved insulin sensitivity[34,35]
    • Decreased blood pressure[36]
    • Better general well-being[36]

    Since the effects aren’t insanely strong, green tea is often overlooked, but there are definitely health benefits to both supplementing the extract and/or drinking green tea that more dieters should be aware of. It’s always good to see, but we don’t ever tell anyone to rely on it alone.

  • Grains of Paradise Extract (Aframomum Melegueta)(seed) (Paradoxine) – 40mg

    If you can handle the 400mg caffeine and supporting ingredients in two capsules of White Heat, you’ll be treated to a clinical 40mg dosage of grains of paradise extract, a potent spice that leads to incredible diet-related benefits. Also known as Aframomum melegueta this member of the ginger family first showed the abilities to decrease blood sugar levels and reduce inflammation.[37-39]

    Grains of Paradise

    They’re not just for cooking anymore! Grains of Paradise seeds can be used for weight loss and body recomposition!

    In 2013, researchers put the spice’s effects to the test by giving 19 healthy men 40mg grains of paradise extract, measuring whole body energy expenditure after measuring their baseline a day prior.[40]

    They found that those who were given grains of paradise had 5% more energy expenditure in just two hours compared to the control group that did not receive the spice![40]

    The next year, in 2014, the researchers tested it for a full month, giving 30mg grains of paradise per day in a placebo-controlled study on 19 healthy females. The researchers tested whole-body energy expenditure and visceral body fat before and after the study.

    Energy Expenditure Chart

    Researchers found that the group consuming the Grains of Paradise extract had a significantly greater increase in energy expenditure, due to increased BAT activity, than the group not receiving the GoP extract.[41]

    When done, grains of paradise significantly decreased visceral fat and increased energy expenditure. They determined that the GP group burnt about 100 calories more per day than the placebo group![41]

    The loss of visceral fat was also critically important, since this is the fat around critical organs and is most metabolically dangerous. It’s the first type of fat the body will burn, and is a top priority to reduce.

    You can learn more about grains of paradise in our article titled Grains of Paradise: Fat Fighting Spice of the Goddesses.

  • Gamma-Butyrobetaine Hydrochloride (GBB) – 25mg

    Now comes the heat in White Heat! The story here is with carnitine, but the effect is an amplified sweat effect when training! Gamma-Butyrobetaine, or GBB, helps us produce more carnitine[42-44] — it’s a pro-carnitine ingredient.

    VMI Sports L-Carnitine 1500 Heat

    L-Carnitine supplements have been getting some “enhancements” lately, thanks to some hot new thermogenic ingredients! Featured: VMI Sports L-Carnitine 1500 Heat

    This is important, because carnitine helps with fatty acid transport to the mitochondria, enabling our cell’s “powerhouses” to generate more ATP.[45] More carnitine can lead to more weight loss and lower BMI[46] and better blood sugar response[47]especially if supplemented in those who are deficient (generally vegans/vegetarians, the elderly, and hard-training athletes).[48-54]

    It’s worth noting that the studies cited in the paragraph above are in terms of carnitine supplementation, not GBB, but the point is that more carnitine is generally a very good thing.

    On top of eating more high-protein red meat, the two main ways to supplementally boost carnitine levels are to

    1. Take any form of L-carnitine (liquid or powder)
    2. Take an L-carnitine precursor to generate more carnitine yourself
    Carnitine Biosynthesis Pathway

    Generate more carnitine! The Carnitine Biosynthesis Pathway.[42] GBB, or γBB, is circled in red.

    VMI Sports is no stranger to carnitine supplements, with L-Carnitine 3000 and L-Carnitine 1500 Heat (which also has GBB).

    Thanks to an enzyme named gamma-butyrobetaine dioxygenase, when we take GBB, we get more converted to carnitine in our systems![42,43] This is great, but the really interesting effect is that it makes some dieters sweat more, especially when training.[44]

    With this effect, GBB packs a punch in a small dose, which is perfect for a two-capsule supplement like White Heat.

    There are additional benefits discussed in our article titled GBB (Gamma-Butyrobetaine Ethyl Ester): Super Carnitine That Makes You Sweat?! Including nitric oxide amplification and more. The point here is that White Heat is going to live up to its name, especially with the stims and spices next to GBB.

  • Fucoxanthin 10% (Laminaria japonica)(seaweed) – 10mg

    Fucoxanthin is a compound present in seaweed that enhances carb metabolism and GLUT4 expression in skeletal muscle.[55,56] Basically, this ensures that more carbs eaten get stored in muscle tissue as opposed to fat stores.

    Fucoxanthin also can act as as a beta-3 adrenergic agonist in white fat cells[57], increasing Uncoupling Protein 1 (UCP1) activity, which results in a higher metabolic rate, and ultimately faster fat loss.[58]

    Animal research has also shown consumption of seaweeds high in fucoxanthin can inhibit the growth of fat cells and increase satiety.[59]

    VMI Sports ProtoLyte

    VMI Sports has impressed us with their flavoring lately, so they told us that their new Protolyte whey isolate flavors are even better! Bring it VMI!

    Given such promising research, the fact that very few of us eat seaweed anymore (it’s also rich in thyroid-critical iodine), and small doses needed, we’d like to see more fat burners add fucoxanthin in. VMI Sports has taken the lead in bringing it back with White Heat.

  • Banaba Extract (Lagerstroemia speciosa)(leaf) – 10mg

    So far, we haven’t covered blood sugar control much, and that’s a critical component to dieting. Reason being, when blood sugar levels (or insulin) are high, fat oxidation slows dramatically[60,61] — after all, you’re burning sugar, not fat. The bacopa may indirectly fight against chronic blood sugar elevation, but banaba extract will provide some direct support.

    The primary constituent of banaba is corosolic acid, but we unfortunately don’t know the standardization. The good news, however, is that much of the research uses a 10 milligram banaba dose, and several studies show that banaba can help reduce fasting and postprandial blood sugar levels by 10% in insulin-resistant users.[62-65]

    Mechanistically, animal studies have shown that banaba can help activate GLUT4 receptors in muscle tissue,[64] — which should pair well with fucoxanthin in helping us store glucose as muscle instead of fat, assuming you’re training and your glycogen stores aren’t constantly full.

    Some in vitro research even suggests that banaba might prevent carbohydrate absorption/digestion,[65] but we never like to rely on such functions. When it comes to carbs, eat what you athletically need to perform, and try not to have constantly high blood sugar around the clock.

  • Black Pepper Extract (Piper nigrum)(fruit)(Bioperine) – 5mg

    BioPerine is an absorption-enhancing agent that brings a high-quality black pepper extract standardized for piperine, and it can greatly enhance nutrient uptake!

    White Heate

    White Heat is available now!

    The piperine inside works by inhibiting P-glycoprotein and CYP3A4 in humans,[66] key enzymes used to metabolize nutrients and even drugs. By inhibiting them, we can keep nutrients in the bloodstream longer.

    While we don’t have a great deal of specific research on Bioperine’s amplification of the weight loss ingredients in White Heat, we have seen it work with several including beta-carotene,[67] coenzyme Q10,[68] curcumin (2000%!),[69] resveratrol,[70] and vitamin B6.[71]

    Further, there are potential effects that black pepper extract can possibly increase mitochondrial capacity[72] so you can generate more energy — but note that the study is confounded with resveratrol, which we don’t have here. Still very interesting, and you might just get a sliver more heat from that black pepper too!

    5 milligrams is the standard dose. Now back to two more ingredients, one of which is really going to up the intensity:

  • Alpha Yohimbine Hydrochloride (Rauwolfia vomitoria)(whole plant) – 1.5mg

    Time to take that caffeine and theacrine to the next level – with a solid 1.5mg strike of alpha yohimbine! Affectionately known as “alpha yo”, this ingredient comes from rauwolfia and provides an intense, fat-blocking effect due to its ability to block alpha-2 adrenergic receptors.[73,74]

    VMI Sports White Heat Benefits

    Torch it with White Heat!

    This mechanism leads to some intense effects, including:

    • Enhanced energy
    • Increased fat loss
    • Improved mood
    • Amplified libido
    • Appetite suppression[73,74]

    As an alpha-2 antagonist, alpha yohimbine can block substrates from binding to alpha-2 receptors. That may lead to fat storage prevention and more energy – but you’ll need to burn that fat, which is why we’re all about training after taking White Heat or other alpha-yohimbine-containing supplements.

  • Toothed Clubmoss (Huperzia serrata)(aerial parts) (1% Huperzine A) – 1mg

    Finally, we get a bit more focus retention from Huperzine A, which works to keep our acetylcholine levels high since it is an acetylcholinesterase inhibitor.[75] While there’s no choline added to White Heat, meaning we’re not getting an added acetylcholine boost, we are still getting to keep some acetylcholine stores around for a longer period of time, and this is known to have neuroprotective effects.[76]

  • Also worth noting is that we have the higher quality form of Vitamin B12 in methylcobalamin, which we always greatly prefer over the cheaper cyanocobalamin forms.[77-80]

White Heat Dosage

VMI Sports White Heat Instructions

One cap or two – the choice is yours, but choose wisely!

Your options are pretty simple with White Heat – two capsules per day to get the full effects. The question is… are you going to slam them both at once, or space them out in the day?

Either way is fine, but note that it’s probably best to take one at a time to assess your tolerance first – that double capsule dose is going to bring it.

VMI Sports Finally Has a Fat Burner!

Years ago, too many companies did nothing but load caffeine (and not much else) into fat burners. After a while, the industry shied away from the practice… all while loading tons of caffeine into pre workout supplements! However, there is a market for high-caffeine weight loss aids, and it’s relatively unserved.

Now it’s time to bring the energy back, yet with other useful ingredients like grains of paradise, fucoxanthin, alpha-yohimbine, and banaba. In addition, the bacopa and L-theanine blend here should definitely make it feel good.

We expect no different from the brand that brought us K-XR (the OGs of the Miami Vice flavor system). The biggest surprise is that it took this long for VMI to come out with a capsule fat burner. They did it, and they did it in a high-powered way with White Heat.

Stack this one with either of VMI’s L-Carnitine supplements and get ready for some White Heat.

VMI Sports White Heat - Ultra Burn – Deals and Price Drop Alerts

Get Price Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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  1. Astrup, A, et al. “Caffeine: A Double-Blind, Placebo-Controlled Study of Its Thermogenic, Metabolic, and Cardiovascular Effects in Healthy Volunteers.” The American Journal of Clinical Nutrition, vol. 51, no. 5, 1 May 1990, pp. 759–767, 10.1093/ajcn/51.5.759. https://www.ncbi.nlm.nih.gov/pubmed/2333832
  2. Correa, Mercè, et al. “Caffeine Modulates Food Intake Depending on the Context That Gives Access to Food: Comparison with Dopamine Depletion.” Frontiers in Psychiatry, vol. 9, 6 Sept. 2018, 10.3389/fpsyt.2018.00411. https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00411/full
  3. Institute of Medicine. “Pharmacology of Caffeine.” Nih.gov, National Academies Press (US), 2014. https://www.ncbi.nlm.nih.gov/books/NBK223808/
  4. Aguiar S, Borowski T. Neuropharmacological Review of the Nootropic Herb Bacopa monnieri. Rejuvenation Research. 2013;16(4):313-326. doi:10.1089/rej.2013.1431. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/
  5. Kumar N, Abichandani LG, Thawani V, Gharpure KJ, Naidu MUR, Venkat Ramana G. Efficacy of Standardized Extract of Bacopa monnieri on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial. Evidence-based Complementary and Alternative Medicine : eCAM. 2016;2016:4103423. doi:10.1155/2016/4103423. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075615/
  6. Bhandari P, Kumar N, Singh B, Kaur I. Dammarane triterpenoid saponins from Bacopa monnieri. Can J Chem. 2009;87(9):1230-1234. doi:10.1139/V09-111. http://www.nrcresearchpress.com/doi/abs/10.1139/V09-111#.WdTnA8iGPIV
  7. Benson S, Downey LA, Stough C, Wetherell M, Zangara A, Scholey A. An acute, double-blind, placebo-controlled cross-over study of 320 mg and 640 mg doses of Bacopa monnieri (CDRI 08) on multitasking stress reactivity and mood. Phytother Res. 2014;28(4):551-559. doi:10.1002/ptr.5029. https://www.ncbi.nlm.nih.gov/pubmed/23788517
  8. Sheikh N, Ahmad A, Siripurapu KB, Kuchibhotla VK, Singh S, Palit G. Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats. J Ethnopharmacol. 2007;111(3):671-676. doi:10.1016/j.jep.2007.01.025. https://www.ncbi.nlm.nih.gov/pubmed/17321089
  9. Russo A, Borrelli F. Bacopa monniera, a reputed nootropic plant: an overview. Phytomedicine. 2005;12(4):305-317. doi:10.1016/j.phymed.2003.12.008. https://www.ncbi.nlm.nih.gov/pubmed/15898709/
  10. Charles PD, Ambigapathy G, Geraldine P, Akbarsha MA, Rajan KE. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation. J Ethnopharmacol. 2011;134(1):55-61. doi:10.1016/j.jep.2010.11.045. https://www.ncbi.nlm.nih.gov/pubmed/21129470
  11. Thomas RB, Joy S, Ajayan MS, Paulose CS. Neuroprotective potential of Bacopa monnieri and Bacoside A against dopamine receptor dysfunction in the cerebral cortex of neonatal hypoglycaemic rats. Cell Mol Neurobiol. 2013;33(8):1065-1074. doi:10.1007/s10571-013-9973-0. https://www.ncbi.nlm.nih.gov/pubmed/23975094
  12. Mathew J, Balakrishnan S, Antony S, Abraham PM, Paulose C. Decreased GABA receptor in the cerebral cortex of epileptic rats: effect of Bacopa monnieri and Bacoside-A. Journal of Biomedical Science. 2012;19(1):25. doi:10.1186/1423-0127-19-25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306740/
  13. Malhotra CK, Das PK. Pharmacological studies of Herpestis monniera Linn (Brahmi). Ind J Med Res 1959;47:294-305 https://www.ncbi.nlm.nih.gov/pubmed/13664331
  14. Gohil K, Patel J. A review on Bacopa monniera: Current research and future prospects. Int J Green Pharm. 2010;4(1):1. doi:10.4103/0973-8258.62156. http://greenpharmacy.info/index.php/ijgp/article/viewFile/111/154
  15. Vollala VR, Upadhya S, Nayak S. Effect of Bacopa monniera Linn. (brahmi) extract on learning and memory in rats: A behavioral study. J Vet Behav Clin Appl Res. 2017;5(2):69-74. doi:10.1016/j.jveb.2009.08.007. http://www.journalvetbehavior.com/article/S1558-7878%2809%2900340-2/abstract
  16. Agrawal A, Gupta U, Dixit SP, Dubey GP. Changes in brain biogenic amines under the influence of an Ayurvedic drug, Brahmi, and its effect on discrimination learning. Pharmacopsychoecologia 1993;6(1):15-9.
  17. Dubey GP, Pathak SR, Gupta BS. Combined effect of Brahmi (Bacopa monniera)and Shankhpushpi (Convolvulus pluricaulis) on cognitive functions. Pharmacopsychoecologia 1994;7(3):249-51.
  18. Stough C, Scholey A, Cropley V, et al. Examining the cognitive effects of a special extract of Bacopa monniera (CDRI08: Keenmnd): a review of ten years of research at Swinburne University. J Pharm Pharm Sci. 2013;16(2):254-258. https://journals.library.ualberta.ca/jpps/index.php/jpps/article/view/19609/15279
  19. Neale, C., Camfield,D., Reay, J, Stough, C. & Scholey, A. Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes. British Journal of Clinical Pharmacology, 2013; https://www.ncbi.nlm.nih.gov/pubmed/23043278
  20. Rastogi M, Ojha RP, Devi BP, Aggarwal A, Agrawal A, Dubey GP. Amelioration of age associated neuroinflammation on long term bacosides treatment. Neurochem Res. 2012;37(4):869-874. doi:10.1007/s11064-011-0681-1. https://www.ncbi.nlm.nih.gov/pubmed/22198697
  21. Tamara Simpson, Matthew Pase, and Con Stough, “Bacopa monnieri as an Antioxidant Therapy to Reduce Oxidative Stress in the Aging Brain,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 615384, 9 pages, 2015. doi:10.1155/2015/615384. https://www.hindawi.com/journals/ecam/2015/615384/
  22. Wirth MM, Scherer SM, Hoks RM, Abercrombie HC. The effect of cortisol on emotional responses depends on order of cortisol and placebo administration in a within-subjects design. Psychoneuroendocrinology. 2011;36(7):945-954. doi:10.1016/j.psyneuen.2010.11.010. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110569/
  23. Epel ES, McEwen B, Seeman T, et al. Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom Med. 2000;62(5):623-632. https://www.ncbi.nlm.nih.gov/pubmed/11020091
  24. Peeters GMEE, van Schoor NM, van Rossum EFC, Visser M, Lips P. The relationship between cortisol, muscle mass and muscle strength in older persons and the role of genetic variations in the glucocorticoid receptor. Clin Endocrinol (Oxf). 2008;69(4):673-682. doi:10.1111/j.1365-2265.2008.03212.x. https://www.ncbi.nlm.nih.gov/pubmed/18248637
  25. Yau YHC, Potenza MN. Stress and Eating Behaviors. Minerva endocrinologica. 2013;38(3):255-267. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214609/
  26. Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional neuroscience, 11(4), 193-198; https://www.ncbi.nlm.nih.gov/pubmed/18681988
  27. Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional neuroscience, 13(6), 283-290; https://www.ncbi.nlm.nih.gov/pubmed/21040626
  28. Kelly, S. P., Gomez-Ramirez, M., Montesi, J. L., & Foxe, J. J. L-Theanine and Caffeine in Combination Affect Human Cognition as Evidenced by Oscillatory alpha-Band Activity and Attention Task Performance. The Journal of Nutrition, 138(8); https://academic.oup.com/jn/article/138/8/1572S/4750819
  29. amada, Takashi, et al. “Theanine, R-Glutamylethylamide, Increases Neurotransmission Concentrations and Neurotrophin MRNA Levels in the Brain during Lactation.” Life Sciences, vol. 81, no. 16, 29 Sept. 2007, pp. 1247–1255, 10.1016/j.lfs.2007.08.023. https://pubmed.ncbi.nlm.nih.gov/17904164
  30. McLellan, T. et al. Dec. 2016. “A Review of Caffeine’s Effects on Cognitive, Physical and Occupational Performance.” Neuroscience & Biobehavioral Reviews vol. 71. 294-312. https://www.sciencedirect.com/science/article/pii/S0149763416300690
  31. Trexler, E. et al. Sep. 2016. “Effects of Coffee and Caffeine Anhydrous on Strength and Sprint Performance.” European Journal of Sport Science vol. 16,6. 702-10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803635/
  32. Hursel, R., et al. “The Effects of Catechin Rich Teas and Caffeine on Energy Expenditure and Fat Oxidation: A Meta-Analysis.” Obesity Reviews, vol. 12, no. 7, 2 Mar. 2011, pp. e573–e581, 10.1111/j.1467-789x.2011.00862.x; https://onlinelibrary.wiley.com/doi/full/10.1111/j.1467-789X.2011.00862.x
  33. Ras, Rouyanne T., et al. “Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis.” PLoS ONE, vol. 6, no. 3, 4 Mar. 2011, p. e16974, 10.1371/journal.pone.0016974; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048861/
  34. Hsu, Chung-Hua, et al. “Does Supplementation with Green Tea Extract Improve Insulin Resistance in Obese Type 2 Diabetics? A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.” Alternative Medicine Review: A Journal of Clinical Therapeutic, vol. 16, no. 2, 1 June 2011, pp. 157–163; https://pubmed.ncbi.nlm.nih.gov/21649457/ (full text PDF)
  35. Venables, Michelle C, et al. “Green Tea Extract Ingestion, Fat Oxidation, and Glucose Tolerance in Healthy Humans.” The American Journal of Clinical Nutrition, vol. 87, no. 3, 1 Mar. 2008, pp. 778–784, 10.1093/ajcn/87.3.778; https://academic.oup.com/ajcn/article/87/3/778/4633440
  36. Brown, A. Louise, et al. “Effects of Dietary Supplementation with the Green Tea Polyphenol Epigallocatechin-3-Gallate on Insulin Resistance and Associated Metabolic Risk Factors: Randomized Controlled Trial.” British Journal of Nutrition, vol. 101, no. 6, 19 Aug. 2008, pp. 886–894, 10.1017/s0007114508047727; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819662/
  37. Al-Amin, Zainab M, et al; “Anti-Diabetic and Hypolipidaemic Properties of Ginger (Zingiber Officinale) in Streptozotocin-Induced Diabetic Rats.”; The British Journal of Nutrition; U.S. National Library of Medicine; Oct. 2006; https://www.ncbi.nlm.nih.gov/pubmed/17010224/
  38. Jolad, Shivanand D, et al; “Commercially Processed Dry Ginger (Zingiber Officinale): Composition and Effects on LPS-Stimulated PGE2 Production.”; Phytochemistry; U.S. National Library of Medicine; July 2005; https://www.ncbi.nlm.nih.gov/pubmed/15996695
  39. Ilic, Nebojsa et al.; “Toxicological evaluation of grains of paradise (Aframomum melegueta) [Roscoe] K. Schum.”; Journal of ethnopharmacology; vol. 127,2; 2010; 352-6; doi:10.1016/j.jep.2009.10.03; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3815460/
  40. Sugita, Jun, et al; “Grains of Paradise (Aframomum Melegueta) Extract Activates Brown Adipose Tissue and Increases Whole-Body Energy Expenditure in Men.”; The British Journal of Nutrition; U.S. National Library of Medicine; Aug. 2013; https://www.ncbi.nlm.nih.gov/pubmed/23308394
  41. Sugita, Jun, et al; “Daily Ingestion of Grains of Paradise (Aframomum Melegueta) Extract Increases Whole-Body Energy Expenditure and Decreases Visceral Fat in Humans.”; Journal of Nutritional Science and Vitaminology; U.S. National Library of Medicine; 2014; https://www.ncbi.nlm.nih.gov/pubmed/24759256
  42. Strijbis K, Vaz F, Distel B; “Enzymology of the carnitine biosynthesis pathway”; IUBMB Life; 2010 May; 62(5):357-62; https://pubmed.ncbi.nlm.nih.gov/20306513
  43. Paul HS, Sekas G, Adibi SA (Feb 1992). “Carnitine biosynthesis in hepatic peroxisomes. Demonstration of gamma-butyrobetaine hydroxylase activity”. European Journal of Biochemistry / FEBS. 203 (3): 599–605. doi:10.1111/j.1432-1033.1992.tb16589.x. PMID 1735445; https://pubmed.ncbi.nlm.nih.gov/1735445
  44. Charles J. Rebouche, E. Peter Bosch, Catherine A. Chenard, Kay J. Schabold, Steven E. Nelson; “Utilization of Dietary Precursors for Carnitine Synthesis in Human Adults”; The Journal of Nutrition, Volume 119, Issue 12, 1 December 1989, Pages 1907–1913; https://academic.oup.com/jn/article-abstract/119/12/1907/4738183
  45. Sahlin, K. “Boosting Fat Burning With Carnitine: An Old Friend Comes Out from the Shadow.” Journal of Physiology vol. 589,Pt 7 (2011): 1509-10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099008/
  46. Pooyandjoo, M., et al. “The Effect of (L-)Carnitine on Weight Loss in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Obesity Reviews, vol. 17, no. 10, 22 June 2016, pp. 970–976, 10.1111/obr.12436. https://pubmed.ncbi.nlm.nih.gov/27335245/
  47. Ruggenenti, Piero, et al. “Ameliorating Hypertension and Insulin Resistance in Subjects at Increased Cardiovascular Risk: Effects of Acetyl-L-Carnitine Therapy.” Hypertension (Dallas, Tex.: 1979), vol. 54, no. 3, 1 Sept. 2009, pp. 567–574, 10.1161/HYPERTENSIONAHA.109.132522. https://pubmed.ncbi.nlm.nih.gov/19620516/
  48. Fielding, Roger, et al. “L-Carnitine Supplementation in Recovery after Exercise.” Nutrients, vol. 10, no. 3, 13 Mar. 2018, p. 349, 10.3390/nu10030349. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/
  49. Krajcovicová-Kudlácková, M., et al. “Correlation of Carnitine Levels to Methionine and Lysine Intake.” Physiological Research, vol. 49, no. 3, 2000, pp. 399–402; https://pubmed.ncbi.nlm.nih.gov/11043928/
  50. Lombard, K A, et al. “Carnitine Status of Lactoovovegetarians and Strict Vegetarian Adults and Children.” The American Journal of Clinical Nutrition, vol. 50, no. 2, 1 Aug. 1989, pp. 301–306, 10.1093/ajcn/50.2.301; https://academic.oup.com/ajcn/article-abstract/50/2/301/4651007
  51. Krajcovicová-Kudlácková, M., et al. “Correlation of Carnitine Levels to Methionine and Lysine Intake.” Physiological Research, vol. 49, no. 3, 2000, pp. 399–402; https://pubmed.ncbi.nlm.nih.gov/11043928/
  52. Rebouche, Charles J. “Carnitine Function and Requirements during the Life Cycle.” The FASEB Journal, vol. 6, no. 15, Dec. 1992, pp. 3379–3386, 10.1096/fasebj.6.15.1464372; https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.6.15.1464372
  53. Malaguarnera, Mariano, et al. “Serum Carnitine Levels in Centenarians.” Clinical Drug Investigation, vol. 17, no. 4, 1999, pp. 321–327, 10.2165/00044011-199917040-00008; https://link.springer.com/article/10.2165/00044011-199917040-00008
  54. Malaguarnera, Mariano, et al. “L-Carnitine Treatment Reduces Severity of Physical and Mental Fatigue and Increases Cognitive Functions in Centenarians: A Randomized and Controlled Clinical Trial.” The American Journal of Clinical Nutrition, vol. 86, no. 6, 1 Dec. 2007, pp. 1738–1744, 10.1093/ajcn/86.5.1738; https://pubmed.ncbi.nlm.nih.gov/18065594/
  55. u X, et al; “Combination of fucoxanthin and conjugated linoleic acid attenuates body weight gain and improves lipid metabolism in high-fat diet-induced obese rats”; Arch Biochem Biophys; 2012; https://pubmed.ncbi.nlm.nih.gov/22289788/
  56. Maeda H, et al; “Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model”; Mol Med Report; 2009; https://pubmed.ncbi.nlm.nih.gov/21475918/
  57. Maeda H, et al; “Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues”; Biochem Biophys Res Commun; 2005; https://pubmed.ncbi.nlm.nih.gov/15896707/
  58. Abidov M, et al; “The effects of Xanthigen in the weight management of obese premenopausal women with non-alcoholic fatty liver disease and normal liver fat”; Diabetes Obes Metab; 2010; https://pubmed.ncbi.nlm.nih.gov/19840063/
  59. Woo, Myoung-Nam, et al. “Fucoxanthin Supplementation Improves Plasma and Hepatic Lipid Metabolism and Blood Glucose Concentration in High-Fat Fed C57BL/6N Mice.” Chemico-Biological Interactions, vol. 186, no. 3, Aug. 2010, pp. 316–322, 10.1016/j.cbi.2010.05.006; https://pubmed.ncbi.nlm.nih.gov/20519145/
  60. Sidossis, L, et al; “Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed”; American Journal of Physiology; 270(4 Pt 1):E733-8; April 1996; https://pubmed.ncbi.nlm.nih.gov/8928782
  61. Bonadonna, R; “Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans”; The American Journal of Physiology; 259(5 Pt 1):E736-50; November 1990; https://pubmed.ncbi.nlm.nih.gov/2240211
  62. Fukushima, M., Matsuyama, F., Ueda, N., Egawa, K., Takemoto, J., Kajimoto, Y., Seino, Y. (2006). Effect of corosolic acid on postchallenge plasma glucose levels. Diabetes Research and Clinical Practice, 73(2), 174–177. doi:10.1016/j.diabres.2006.01.010; https://www.ncbi.nlm.nih.gov/pubmed/16549220
  63. Miura, T., Takagi, S., & Ishida, T. (2012). Management of Diabetes and Its Complications with Banaba (Lagerstroemia speciosa L.) and Corosolic Acid. Evidence-Based Complementary and Alternative Medicine, 2012, 1–8. doi:10.1155/2012/871495; https://www.ncbi.nlm.nih.gov/pubmed/23082086
  64. Miura, T., Itoh, Y., Kaneko, T., Ueda, N., Ishida, T., Fukushima, M., … Seino, Y. (2004). Corosolic Acid Induces GLUT4 Translocation in Genetically Type 2 Diabetic Mice. Biological & Pharmaceutical Bulletin, 27(7), 1103–1105. doi:10.1248/bpb.27.1103; https://www.ncbi.nlm.nih.gov/pubmed/15256748
  65. Hou, W., Li, Y., Zhang, Q., Wei, X., Peng, A., Chen, L., & Wei, Y. (2009). Triterpene acids isolated from Lagerstroemia speciosa leaves asα-glucosidase inhibitors. Phytotherapy Research, 23(5), 614–618. doi:10.1002/ptr.2661; https://www.ncbi.nlm.nih.gov/pubmed/19107840
  66. Bhardwaj, Rajinder K, et al; “Piperine, a Major Constituent of Black Pepper, Inhibits Human P-Glycoprotein and CYP3A4.”; The Journal of Pharmacology and Experimental Therapeutics; U.S. National Library of Medicine; Aug. 2002; https://www.ncbi.nlm.nih.gov/pubmed/12130727
  67. Badmaev, V., et al; “Piperine, an Alkaloid Derived from Black Pepper Increases Serum Response of Beta-Carotene during 14-Days of Oral Beta-Carotene Supplementation.”; Nutrition Research; Elsevier; 30 June 1999; https://www.sciencedirect.com/science/article/pii/S027153179900007X
  68. Badmaev, V., et al; “Piperine Derived from Black Pepper Increases the Plasma Levels of Coenzyme q10 Following Oral Supplementation.”; The Journal of Nutritional Biochemistry; Elsevier; 9 Mar. 2000; https://www.sciencedirect.com/science/article/pii/S0955286399000741?via%3Dihub
  69. Shoba, G, et al;. “Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers.”; Planta Medica; U.S. National Library of Medicine; May 1998; https://www.ncbi.nlm.nih.gov/pubmed/9619120
  70. Johnson, J., et al; “Enhancing the bioavailability of resveratrol by combining it with piperine.”; Mol Nutr Food Res; 55(8); pp. 1169-1176; August 2011; https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201100117 (full-text archive)
  71. Vitamin B6; BioPerine; https://web.archive.org/web/20210624164901/https://bioperine.com/vitamin-b6/
  72. Polley, Kristine R, et al; “Influence of Exercise Training with Resveratrol Supplementation on Skeletal Muscle Mitochondrial Capacity.”; Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee; Nutrition Et Metabolisme; U.S. National Library of Medicine; Jan. 2016; https://www.ncbi.nlm.nih.gov/pubmed/26638911
  73. Perry B. et al. Dec. 1981.”(3H)Rauwolscine (alpha-yohimbine): A Specific Antagonist Radioligand for Brain Alpha 2-Adrenergic Receptors.” European Journal of Pharmacology vol. 76,4; 461-4. https://pubmed.ncbi.nlm.nih.gov/6276200
  74. Garenc C. et al. Feb. 2002. “The Alpha 2-Adrenergic Receptor Gene and Body Fat Content and Distribution: The Heritage Family Study.” Molecular Medicine vol. 8,2; 88-94. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039973/
  75. Zhao, Qin, and Xi Can Tang. “Effects of Huperzine a on Acetylcholinesterase Isoforms in Vitro: Comparison with Tacrine, Donepezil, Rivastigmine and Physostigmine.” European Journal of Pharmacology, vol. 455, no. 2-3, 29 Nov. 2002, pp. 101–107, 10.1016/s0014-2999(02)02589-x. https://pubmed.ncbi.nlm.nih.gov/12445575/
  76. Ma, Tuo, et al. “Huperzine a Promotes Hippocampal Neurogenesis in Vitro and in Vivo.” Brain Research, vol. 1506, 19 Apr. 2013, pp. 35–43, 10.1016/j.brainres.2013.02.026. https://www.ncbi.nlm.nih.gov/pubmed/23454433
  77. Herbert, V; “Vitamin B-12: Plant Sources, Requirements, and Assay”; Am J Clin Nutr September 1988; vol. 48 no. 3 852-858; http://ajcn.nutrition.org/content/48/3/852.long
  78. Bottiglieri, T; “Folate, vitamin B₁₂, and S-adenosylmethionine”; Psychiatr Clin North Am. 2013 Mar;36(1):1-13; http://www.ncbi.nlm.nih.gov/pubmed/23538072
  79. Obeid, R., Fedosov, S. N. and Nexo, E. (2015), “Cobalamin coenzyme forms are not likely to be superior to cyano- and hydroxyl-cobalamin in prevention or treatment of cobalamin deficiency”; Mol. Nutr. Food Res., 59: 1364–1372; http://onlinelibrary.wiley.com/doi/10.1002/mnfr.201500019/full
  80. Adams, J; “Absorption of cyanocobalamin, coenzyme B 12 , methylcobalamin, and hydroxocobalamin at different dose levels”; Scand J Gastroenterol. 1971;6(3):249-52; http://www.ncbi.nlm.nih.gov/pubmed/5560708

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