Prime Nutrition Partition-MD – Potent Nutrient Partitioning Catalyst

Partition-MD

Prime’s Partition-MD can potentially make you use your carbs a WHOLE lot better

Prime Nutrition is teaming up with the “Mad Dog”, John Meadows, again to bring you another cutting edge supplement designed to take your fitness and nutrition to the next level.

Only a few short months ago, they gave us the ultimate intra-workout supplement with Intra-MD. Now, we may have the ultimate nutrient partitioning supplement in the form of Partition-MD.

Never heard of a nutrient partitioner or used one before? Don’t worry, we’ll explain what it is and what sets Partition-MD apart for the competition.

The short story is that if you want to better utilize your carbohydrates, or are carb-sensitive (and they seem to make you gain more fat than you’d like), this is the kind of product you are going to want to try out.

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What are Nutrient Partitioners?

Partition-MD is marketed as a “nutrient partitioning catalyst.” This is a really fancy way of saying it is a supplement that will optimize carbohydrate uptake by muscle cells in the body as opposed to fat cells. These are nothing new or ground-breaking to the industry, and you may have also seen them referred to as “glycogen-disposal agents” or GDAs.

In an ideal world, every calorie you eat would go towards fueling muscle building and repair, and every calorie you burned would come from your stored fat reserves. Unfortunately, this is rarely the case. Supplements like Partition-MD contain ingredients designed to maximize nutrient uptake by the body and ensure what you’re eating goes to where it’s needed the most.

Partition-MD’s Ingredients

Prime Nutrition Partition MD Ingredients

Partition-MD’s ingredient list uses a mix of ingredients proven to be particularly effective for those with poor insulin sensitivity.

  • Cinnulin PF™ (250mg)

    Cinnulin PF™ is a trademarked water soluble extract of Cinnamomum burmannii. You’ve probably heard of people sprinkling cinnamon on their oatmeal or taking various cinnamon supplements for its benefits in stabilizing blood glucose levels, especially in diabetics.

    However, the cinnamon in your spice cabinet isn’t nearly concentrated enough to reap many of the positive benefits attributed to cinnamon. Cinnulin PF is a highly concentrated and ultra-pure form of cinnamon that has been showing in research to increase lean body mass, lower glucose levels, and reduce overall levels of body fat![4]

  • AuroraBlue™ (100mg)

    AuroraBlue™ is a patented blend of wild Alaskan berries that under a specialized drying process intended to retain their bioactive compounds.[5] Although there’s no research to verify these claims, Denali Biotechnologies (developers of AuroraBlue™) claims that it will help maintain healthy blood glucose and insulin levels, promote heart health, and support brain and memory integrity.[14]

    Denali attributes this to the fact that their complex contains 10x the amount of bioactive compounds (anthocyanins, antioxidants, vitamins, minerals, etc.) as compared to any other berry complexes currently available.

  • Grains-of-Paradise (Seed) (75mg)

    Also known as Aframomum Melegueta, Grains of Paradise is a member of the ginger family. This potent extract stimulates the brown adipose tissue (BAT) to encourage the body to burn excess calories and raise your metabolic rate, rather than store them as fat.[3]

    Prime Nutrition Partition MD

    Prime’s Partition MD claims to be a “nutrient partitioning catalyst”. What’s in it and will it work? Let’s find out! Image courtesy of Stack3d

  • Super Berberine™ (50mg)

    Berberine is a compound extracted from various herbs traditionally used in Chinese medicine. According to a recent meta-analysis, berberine has proven as effective pharmaceutical grade products in reducing blood glucose levels.[1] Additionally, berberine also encourages glucose uptake by muscle cells[2] which is exactly what we’re looking for with nutrient partitioners!

    The problem with most berberine supplements is that they have poor bioavailability in the body, only about 5% is absorbed. Prime’s version of berberine bonds it to a cyclic dextrin molecule which increases its solubility and supposed uptake by the body.

  • Prime Nutrition Partition MD Berberine Graph

    Partition MD uses a novel form of Berberine designed to increase bioavailability and ensure maximum benefit.

  • R-Alpha Lipoic Acid (50mg)

    R-Alpha Lipoic Acid (ALA) is a fatty acid found in the mitochondria of your cells and his heavily involved in energy metabolism. It is naturally made by the body or can be obtained from various meats, fish, and vegetables.ALA is a potent antioxidant in the body and also serves as a coenzyme for carbohydrate metabolism. Aside from these benefits, ALA also exhibits appetite suppressing properties[6] and increases daily energy expenditure.[7,8]

    This particular benefit of ALA makes Partition MD particularly effective if you are in the midst of a tough cutting cycle.

  • Bitter Melon (50mg)

    John Meadows

    The man behind Mountain Dog Training and Partition-MD, John Meadows

    Bitter melon is a vegetable grown in Asia, Africa and the Caribbean. It has a long history in ancient Asian and Indian as a potential treatment for diabetes, respiratory diseases, and a whole host of stomach ailments.

    In clinical studies, bitter melon demonstrated the ability to suppress inflammation in adipose tissue.[9] More importantly, it enhances glucose utilization in the body, increases serum protein levels, and reduces glycogenesis in the liver.[10]

  • Bioperine™ (5mg)

    Bioperine™ is a trademarked black pepper extract guaranteed at least 95% piperine. It enhances the absorption and utilization of nutrients by preventing their early breakdown in your system.

  • Biotin (2.5mg)

    Glucokinase (GK) is an enzyme that is crucial to a cell properly using glucose for energy. When there is a deficiency of GK (such as fasting or diabetes), energy metabolism as well as glucose utilization can be impaired. Luckily, supplementing with Biotin increases GK levels and ensures that your body is using glucose for its intended purpose and not letting it be stored in adipose tissue.[11]

  • Chromium Picolinate (200mcg)

    Chromium is an essential mineral that is responsible for insulin sensitivity and glucose metabolism. Of particular note is its positive effects on glucose disposal[12], especially in those who may have low chromium levels in their diet. Animal studies have also shown that chromium supplementation can increase glycogen storage and production in skeletal muscle.[13]

Dosing

Prime Nutrition Intra-MD

Prime Nutrition started with just basic core supplements, but Intra-MD and Partition-MD are making for a far more intense lineup

Take 1 serving (2 capsules) 2x/day with carbohydrates (preferably complex) just before your two largest meals.

Note that one powerful source of pre- and intra-workout carbs is Prime Nutrition’s Intra-MD, also designed by Meadows. Click the image to the right to read more about it.

Takeaway

Partition-MD contains several components that have shown efficacy with regards to reducing blood glucose levels, increasing glucose uptake by muscle and promoting fat loss. As a strict “nutrient partitioning catalyst”, it may be effective but several of the included ingredients haven’t shown true “partitioning” capabilities.

If you have issues with carbs, it’s definitely worth trying and taking with your carbs. This is a great stimulant-free addition to any carb-eating dieter’s stack, and will stack quite well with Prime’s stimulant-based fat burner, Backdraft XP.

So, it’s tough for us to say whether or not this will be the end-all-be-all to nutrient partitioners, but the formula is extremely solid and an easy way to get into these types of products (also known as glucose disposal agents). Most likely, Partition-MD will be most beneficial to those with poor insulin sensitivity.

John Meadows Explains Partition-MD

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Posts are sponsored in part by the retailers and/or brands listed on this page.

 

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References

  1. Dong H, et al; Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis . Evid Based Complement Alternat Med. (2012)
  2. Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK
  3. Sugita J, et al; Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men . Br J Nutr. (2013)
  4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129164/
  5. http://denalibiotech.com/products/aurorablue/
  6. Kim MS, et al; Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase . Nat Med. (2004)
  7. Cheng PY, et al; Reciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats . Menopause. (2011)
  8. Wang Y, et al; alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice . Metabolism. (2010)
  9. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866167/
  10. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2048984/
  11. Spence JT, Koudelka AP; Effects of biotin upon the intracellular level of cGMP and the activity of glucokinase in cultured rat hepatocytes . J Biol Chem. (1984)
  12. Frauchiger MT, Wenk C, Colombani PC; Effects of acute chromium supplementation on postprandial metabolism in healthy young men . J Am Coll Nutr. (2004)
  13. oginski EE, Mertz W; Effects of Chromium (III) Supplementation on Glucose and Amino Acid Metabolism in Rats Fed a Low Protein Diet . J Nutr. ()
  14. http://denalibiotech.com/products/aurorablue/
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