Dihydroberberine: A Better Berberine

One of the most popular dietary supplement ingredients on the planet — especially in terms of metabolic health — is berberine. Today we discuss a new ingredient that actually makes berberine obsolete.

Berberine is a powerful plant alkaloid that improves the body’s insulin response, with large amounts of scientific research showing significant improvements to insulin sensitivity, fasting glucose levels, HbA1c reduction, nutrient partitioning, and far more. It’s even outperformed pharmaceutical drugs.

Dihydroberberine

Dihydroberberine: A Better Berberine. This article focuses specifically on the higher-bioavailability berberine metabolite, but you can always go back and read our original berberine article to learn more about the mechanisms.

We’ve covered berberine in detail in the article linked above, ultimately finding that while it’s the most impressive ingredient in any blood sugar supplement or glucose disposal agent, it has drawbacks, which include high doses required and GI distress. Both of those problems are solved with one of its derivatives that we specifically cover in this article: dihydroberberine.

Think berberine is good? Take a look at dihydroberberine

Research suggests that dihydroberberine is up to six times better than standard berberine, bringing incredible effects at lower doses — and fewer side effects.

In this article, we assume you have knowledge of berberine’s effects (if not, you can see our berberine article linked above), but jump directly into discussion of this dihydro form. It’s sold as GlucoVantage from NNB Nutrition, one of the supplement industry’s most promising novel ingredient developers.

In addition, we have a podcast episode and video with Shawn Wells, NNB Nutrition’s Chief Science Officer who is a co-patent holder for dihydroberberine,[1] which you can watch as well. Finally, you can try the ingredient on its own by looking at the PricePlow’s dihydroberberine price comparisons below, and signing up for our NNB Nutrition news alerts:

Dihydroberberine Supplements and NNB Nutrition News

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Burn fat, not sugar

The world of diet and fat loss can be overwhelming, but one quick rule to live by is this: when you’re burning sugar, you’re not burning fat. In fact, we’ve known for decades that when either blood glucose levels or insulin levels are elevated, fat oxidation significantly slows.[2,3] If these levels remain elevated for too long, we introduce insulin resistance and hyperinsulinemia, which brings with it a myriad of diseases.[4]

Carbohydrates Displace Fat Oxidation

Every time you eat carbohydrates, you stop burning fat! So why are you wasting time not driving the carbs into muscles? Improve insulin sensitivity and get back to burning fat, not sugar! Image courtesy @TedNaiman

This isn’t to say that we’re against foods like carbohydrates that raise blood sugar (and insulin) levels, because we’re not. Instead, it means that we need to get our carbs to where we want them (muscle tissue!) and get back to a fat-metabolizing state as soon as possible. Berberine, and to a greater extent, dihydroberberine, make that happen better and faster.

We of course still recommend a healthy diet low in refined carbs and void of industrial processed seed oils high in omega-6. But with the above supplemental strategy (which is highlighted in our main berberine article), we can remain more insulin-sensitive, and less likely to be as toxic with sugar and insulin in our blood stream wreaking havoc.

With that goal in mind, we can talk about a new, more-efficient way to achieve it, all while avoiding the massive doses (1.5 grams per day!)[5] and gastrointestinal distress[5,6] that can be brought by standard, low-bioavailability[7,8] berberine:

What is dihydroberberine?

Dihydroberberine Molecule

Dihydroberberine gets absorbed better and faster and then converts back to berberine in plasma anyway!

Dihydroberberine (DHB) is one of the 17 metabolites of berberine, and a major part of the greater berberine life cycle as the body metabolizes it.[9] Structurally, it’s a hydrogenated metabolite of berberine,[10] which itself has markedly better oral bioavailability than berberine itself.[9,11]

The berberine end-around play

The concern, at this point, is that if you take the more-bioavailable dihydroberberine, do you miss out on the 16 other metabolites that may have been providing some of berberine’s benefits? The answer is no, because of the way berberine is absorbed in the first place! After dihydroberberine’s relatively easy absorption in the intestine, it’s oxidized back into berberine, which gets sent into the plasma![9]

This means that dihydroberberine is literally an end-around to berberine’s problem of low bioavailability — you take it, but ultimately end up with a higher amount of berberine in the plasma than had you taken berberine in the first place!

Dihydroberberine: Five times more bioavailable

Dihydroberberine vs. Berberine

Simply put by the researchers: “DhBBR [Dihydroberberine] has a better intestinal absorption than BBR.”[9]

Now that we understand how it gets in, let’s see how much better it is. In 2015, researchers compared oral dihydroberberine to standard berberine. In vitro, they discovered that dihydroberberine’s internal absorption rate was five times greater than berberine’s.[9] They then tested them on mice, noting that DHB was absorbed significantly better than berberine – especially in mice whose intestinal bacteria couldn’t break down berberine as well.

The above study points out something significant: dihydroberberine is less limited by poor gut health, which is very frequently a symptom of those who need it most! Taking an ingredient like GlucoVantage has fewer limiting factors than taking berberine itself.

Comparing the insulin effects of DHB against berberine

In 2008, researchers put dihydroberberine to the test against berberine in mice, giving the berberine group 560mg/kg daily while the DHB group received 100mg/kg each day.[12] The results indicated that dihydroberberine had significantly better improvements in adiposity, triglyceride build-up, and insulin sensitivity (a 44% increase) than berberine — all at a fraction of the dose![12] They concluded that the effect was simply likely due to enhanced oral bioavailability of dihydroberberine.

Better results and fewer side effects at a lower dose

Dihydroberberine Converts To Berberine

Amazingly, dihydroberberine converts back into berberine, and you ultimately end up with more![9]

Further research has shown that dihydroberberine can improve reduced atherosclerotic plaque size and improve plaque stability, where berberine cannot.[11] has better effects and fewer negative effects than berberine in terms of fatty acid absorption.[13]

In terms of side effect profile, GI distress is the major concern for berberine,[5,6] and thus something worth investigating for dihydroberberine. Multiple studies have found that DHB causes fewer stomach problems than berberine.[9,12] Although we can’t guarantee zero stomach discomfort with DHB, it’s far less likely thanks to lower dosing and better absorption.

Anti-inflammatory action: DHB is often stronger, but it depends

While berberine is most frequently used for metabolic health, it also has anti-inflammatory properties that have been compared to dihydroberberine.[14] In most tests performed on mice, but not all, DHB outperforms berberine.[14] In terms of cardiovascular inflammation, dihydroberberine is the clear winner.[11] However, there are some corner cases where berberine did work better, so it’s worth investigating the mechanisms that pertain to your approach.[14]

In general, we look closer to ingredients like curcumin and its metabolites such as tetrahydrocurcumin for more powerful anti-inflammatory effects, but dihydroberberine could make a potent differentiator in an anti-inflammatory supplement stack, especially if the inflammation is metabolic in nature.

Transdermal use is possible

GlucoVantage

There’s no better GDA ingredient than berberine, and there’s no better form of berberine than dihydroberberine in NNB’s GlucoVantage!

Meanwhile, dihydroberberine has also been tested for efficacy transdermally, with greater success than berberine.[15] However, it’s still not as active as orally ingested DHB, and supplements are taken by mouth (legally speaking, they supplement the diet). However, there could be effects for skin care companies, which is out of the scope of this article.

GlucoVantageⓇ – the industry’s first dihydroberberine ingredient!

Shawn Wells, one of the co-inventors on the dihydroberberine patent, has teamed up with NNB Nutrition, one of the world’s leading novel ingredient developers. As the company’s Chief Science Officer, Wells has helped create GlucoVantage, the industry’s first commercially-available dihydroberberine ingredient!

Created from Berberis aristata, GlucoVantage is a pure, non-GMO dihydroberberine that’s created from pure berberine. It’s lab-tested and free of any “spiking” or adulteration, and formulators at supplement brands have access to lab tests demonstrating purity. With a lower dosage required, GlucoVantage fits incredibly well into any blood sugar supplement or glucose disposal agent.

GlucoVantage in one minute

You can learn about GlucoVantage in one minute in the following video:

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The data is clear: if you want a lower-dosed, better-absorbing, and longer-lasting form of berberine that yields fewer side effects, dihydroberberine — and thus GlucoVantage — is the ingredient to use.

Dihydroberberine Dosage

The effective Dihydroberberine Dosage is 30% the dose of standard berberine, giving it far more applications and less GI discomfort!

Dosing

Looking at the available data, a serving of GlucoVantage is best put at 100-200mg, with one to three servings per day. It’s always best to take GlucoVantage before your most insulinogenic, blood-sugar spiking meal, which is generally one that’s high in carbohydrates. Doses on the lower end can also be given to low-carb dieters to keep blood sugars low and continue fat burning.

Stacking

There are several other glucose disposal agent ingredients that can play on GlucoVantage’s supporting cast. An example of one incredible version is Unbound’s SLYN, which is one of the strongest blood sugar modulating supplements we’ve ever seen. With 3rd-party lab tests provided and manufactured in NutraBio’s world-class facility, SLYN is an insanely powerful supplement that’s made possible with GlucoVantage – you likely don’t even need a full dose!

NutraBio Unbound SLYN

Carb-Lovers are going to go nuts over SLYN. But you better bring bigtime carbs to the table if you take all six caps at once!

In terms of stimulant-based fat burners that contain dihydroberberine, Core BLAZE is an extremely unique thermogenic option that has incredible thermogenic and appetite-suppressing effects.

Dihydroberberine is the better berberine

NNB GlucoVantage

GlucoVantage from NNB Nutrition is a pure form of Dihydroberberine (DHB) and is known as “The Super Berberine”.

With the ongoing metabolic crisis, it’s more important than ever that we maintain insulin sensitivity and keep our bodies primed for fat burning – not sugar burning! Carbs are great to employ around workouts, but we don’t want to be in a state of low fat oxidation all day long – and we don’t want them pumped into the liver to be packaged into triglycerides either.

What we do want is to take advantage of our carbohydrates to get them into muscle tissue – something berberine is very good at making our bodies do. However, berberine has some major drawbacks — a high dose needed, low bioavailability, and GI upset. Dihydroberberine solves those problems, and NNB Nutrition’s GlucoVantage is the end result.

Berberine used to be our preferred glucose disposal agent ingredient. But now the answer is clear – dihydroberberine is the future.

Dihydroberberine Supplements and NNB Nutrition News

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

NNB GlucoVantage

GlucoVantage from NNB Nutrition is a pure form of Dihydroberberine (DHB) and is known as “The Super Berberine”.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Wells, Shawn, et al; “Administration of berberine metabolites”; United States Patent US10278961B2; April 19, 2016; https://patents.google.com/patent/US10278961B2/en
  2. Sidossis, L, et al; “Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed”; American Journal of Physiology; 270(4 Pt 1):E733-8; April 1996; https://www.ncbi.nlm.nih.gov/pubmed/8928782
  3. Bonadonna, R; “Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans”; The American Journal of Physiology; 259(5 Pt 1):E736-50; November 1990; https://www.ncbi.nlm.nih.gov/pubmed/2240211
  4. Kelly, CT, et al; “Hyperinsulinemic syndrome: the metabolic syndrome is broader than you think”; Surgery; 156(2):405-11; August 2014; https://pubmed.ncbi.nlm.nih.gov/24962189
  5. Yin, Jun et al; “Efficacy of berberine in patients with type 2 diabetes mellitus.”; Metabolism: clinical and experimental; vol. 57,5; 2008; 712-7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/
  6. Dong, Hui et al; “Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis.”; Evidence-based complementary and alternative medicine : eCAM; vol. 2012; 2012; 591654; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478874/
  7. Wang, S. D., et al. “[Determination of Berberine in Decocted Liquid from Shenshu Granules with Water by Reversed-Phase Liquid Chromatography].” Se Pu = Chinese Journal of Chromatography, vol. 18, no. 3, 1 May 2000, pp. 261–262; https://pubmed.ncbi.nlm.nih.gov/12541570/
  8. Hua, Wenyan, et al. “Determination of Berberine in Human Plasma by Liquid Chromatography-Electrospray Ionization-Mass Spectrometry.” Journal of Pharmaceutical and Biomedical Analysis, vol. 44, no. 4, 15 Aug. 2007, pp. 931–937, 10.1016/j.jpba.2007.03.022; https://pubmed.ncbi.nlm.nih.gov/17531424/
  9. Feng, Ru, et al; “Transforming Berberine into Its Intestine-Absorbable Form by the Gut Microbiota.”; Nature News; Nature Publishing Group; 15 July 2015; https://www.nature.com/articles/srep12155
  10. Pingali, S., et al. “Weak C—H⋯X (X = O, N) Hydrogen Bonds in the Crystal Structure of Di­hydro­berberine.” Acta Crystallographica Section C: Structural Chemistry, vol. 70, no. 4, 15 Apr. 2014, pp. 388–391, 10.1107/S2053229614003751; https://scripts.iucr.org/cgi-bin/paper?S2053229614003751
  11. Chen, Junwen, et al. “Berberine Derivatives Reduce Atherosclerotic Plaque Size and Vulnerability in ApoE−/− Mice.” Journal of Translational Medicine, vol. 12, no. 1, 26 Nov. 2014, 10.1186/s12967-014-0326-7; https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-014-0326-7
  12. Turner, Nigel, et al; “Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I: a Mechanism for the Action of Berberine to Activate AMP-Activated Protein Kinase and Improve Insulin Action.”; Diabetes; U.S. National Library of Medicine; May 2008; https://www.ncbi.nlm.nih.gov/pubmed/18285556
  13. Mohammad, Mohammad, et al; “Inhibition of pancreatic lipase by berberine and dihydroberberine: An investigation by docking simulation and experimental validation.”; Medicinal Chemistry Research; 22(5); April 2013; 2273-2278; https://www.researchgate.net/publication/255979651_Inhibition_of_pancreatic_lipase_by_berberine_and_dihydroberberine_An_investigation_by_docking_simulation_and_experimental_validation
  14. Tan, Lihua, et al. “Dihydroberberine, a Hydrogenated Derivative of Berberine Firstly Identified in Phellodendri Chinese Cortex, Exerts Anti-Inflammatory Effect via Dual Modulation of NF-ΚB and MAPK Signaling Pathways.” International Immunopharmacology, vol. 75, 1 Oct. 2019, p. 105802, 10.1016/j.intimp.2019.105802; https://pubmed.ncbi.nlm.nih.gov/31401380/
  15. Buchanan, Beth et al; “Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine.”; PloS one; vol. 13,3; e0194979; 26 Mar. 2018; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868852/

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