Hosstility RTD: Ready-to-Drink Pre-Workout Power with Cognizin Citicoline

Hosstile Supplements drops Hosstility RTD with no shortcuts: 6g L-citrulline, 5g glycerol, 3.2g beta-alanine, 250mg Cognizin citicoline, and 300mg caffeine. Finally, an RTD pre-workout that doesn’t compromise on clinical dosing.

The ready-to-drink pre-workout market has exploded in recent years, yet most RTD formulas make significant compromises to achieve shelf stability and convenience. But Hosstile Supplements didn’t get that memo.

Founded by IFBB Pro Fouad Abiad, Hosstile has built its reputation on refusing to take shortcuts. The new Hosstility RTD delivers the same aggressive stance on premium ingredients that made their Hosstility AMPED powder a standout in the high-stimulant pre-workout category.

Hostility RTD: Loaded Pre-Workout Drink with 300mg Caffeine and 250mg Cognizin® Citicoline

Their philosophy extends to their first ready-to-drink pre-workout, which packs a fully-disclosed formula featuring 6g L-citrulline, 5g glycerol, 3.2g beta-alanine, and 250mg Cognizin® citicoline into each 12-ounce bottle.

The inclusion of Cognizin citicoline is worth highlighting: This patented form of citicoline from Kyowa Hakko has become the gold standard for cognitive enhancement in sports nutrition. Unlike basic choline sources, Cognizin supports focus, attention, and mental energy while helping maintain productivity during intense training sessions. At 250mg per serving, Hosstility RTD provides a clinically-studied dose that can genuinely be felt.

For athletes and serious lifters who want pre-workout performance without the mixing hassle, Hosstility RTD represents a no-compromise solution. You’re getting the same ingredient quality and dosing philosophy that defines the Hosstile brand, just in a grab-and-go format that fits modern lifestyles.

Ready to experience what a properly-dosed RTD pre-workout feels like? Sign up for PricePlow’s Hosstile Supplements alerts below to stay updated on availability, new flavors, and exclusive deals:

Hosstility RTD Ingredients

Each 12-ounce bottle delivers a fully-disclosed blend of performance ingredients at doses that matter. Here’s what you get in every serving of Hosstility RTD:

• L-Citrulline – 6000mg

  L-citrulline stands as the pump-driving foundation of Hosstility RTD, and at 6g per serving, this formula delivers a clinically-backed dose that can genuinely enhance performance. This non-essential amino acid works through an elegant biological pathway: it converts to L-arginine in the kidneys, which then serves as the substrate for nitric oxide (NO) production via nitric oxide synthase enzymes.

  The beauty of citrulline supplementation lies in its superior bioavailability compared to direct arginine supplementation. While oral L-arginine faces significant presystemic metabolism (with approximately 40% catabolized by intestinal bacteria and arginases on first pass), L-citrulline bypasses these limitations.^[1] Research demonstrates that L-citrulline dose-dependently increases plasma L-arginine concentrations more effectively than equivalent doses of L-arginine itself.

  The nitric oxide pathway activation from citrulline promotes vasodilation, potentially increasing blood flow to working muscles and facilitating better nutrient delivery and waste product removal. This mechanism underlies both the immediate “pump” sensation users experience and the longer-term performance benefits that make citrulline a cornerstone ingredient in serious pre-workout formulations.

  Beyond the classic “pump” benefits, citrulline’s performance advantages extend to exercise capacity and recovery. Studies show that citrulline supplementation can improve oxygen uptake kinetics during high-intensity exercise, enhance exercise tolerance, and reduce the oxygen cost of muscle contraction.^[2] The 6g dose in Hosstility RTD aligns with research showing meaningful improvements in both resistance and endurance exercise performance.

• Glycerol – 5000mg

  Glycerol is a great ingredient to achieve the coveted “water-based pump” that pre-workout users love. Unlike traditional nitric oxide-boosting pump ingredients, glycerol operates through an entirely different mechanism that complements other vasodilators perfectly.

  The Hyperhydration Effect

  When consumed, glycerol rapidly distributes throughout bodily fluids and raises osmotic pressure, which encourages increased water movement and retention throughout the body.^[3] This creates a state of “hyperhydration” where muscles become saturated with water, leading to enhanced pumps and improved performance capacity.

  

  The mechanism is elegantly simple: glycerol acts as a water-drawing agent that pulls fluid into muscle tissue, creating volumization effects that can be felt during training. This water-based pump works synergistically with nitric oxide pathways, meaning you get enhanced vascularity through multiple complementary mechanisms rather than relying on a single pathway.

  Performance and Thermoregulation Benefits

  Research demonstrates that glycerol’s hyperhydration effect extends beyond just pumps. Studies show that glycerol supplementation can increase exercise tolerance by approximately 24% while helping maintain core body temperature during intense training.^[4] This thermoregulatory benefit makes it valuable for anyone training in warm environments or during high-intensity sessions where heat buildup becomes a limiting factor.

  Why 5g Matters in RTD Format

  The 5g dose in Hosstility RTD deserves special recognition. While some powder-based pre-workouts struggle with glycerol’s notorious clumping issues (they leave gritty, unpleasant textures), using it in its true liquid form eliminates these problems entirely. You’re getting a substantial dose without the textural compromises that often plague powdered glycerol formulations, making this one of the most user-friendly ways to experience glycerol’s hyperhydration effects.

  For example, this 5g of pure glycerol is equivalent to 7.7 grams of powdered 65% glycerol — a dose that basically no pre-workout uses! That’s a big win for the Hosstility RTD.

• Beta Alanine – 3200mg

  Beta-alanine is the rate-limiting precursor to carnosine synthesis, making it one of the most researched performance enhancers in sports nutrition. When you take beta-alanine, it combines with histidine in skeletal muscle to form carnosine, a powerful intracellular buffer that helps maintain muscle pH during high-intensity exercise.

  The 3.2g dose in Hosstility RTD sits at the clincial end of the clinically effective range. Research demonstrates that beta-alanine supplementation can increase muscle carnosine concentrations by up to 80% after sustained use, with the greatest benefits occurring in exercise lasting 1-4 minutes.^[5] This timeframe perfectly aligns with the demands of intense training sessions where muscle acidosis typically becomes a limiting factor.

  

  How beta-alanine works

  During high-intensity exercise, your muscles produce hydrogen ions that lower intracellular pH, contributing to that familiar burning sensation and eventual fatigue. Carnosine acts as a buffer against these acid-producing reactions, with its imidazole ring readily accepting protons at physiological pH levels. By increasing muscle carnosine stores through beta-alanine supplementation, you’re essentially expanding your muscle’s capacity to handle acid buildup.

  The effectiveness of beta-alanine becomes most apparent during repeated high-intensity efforts — exactly the type of training that demands peak focus and performance. Recent meta-analyses show significant improvements in maximal intensity exercise, with optimal benefits achieved through doses of 5.6-6.4g per day over 4-week periods.^[6]

  The only commonly reported side effect is paresthesia (tingling sensation), which can be minimized through divided dosing throughout the day. In an RTD format like Hosstility, you’re getting a substantial single dose that maximizes convenience while delivering clinically meaningful amounts of this proven performance enhancer.

• Betaine Anhydrous – 2500mg

  Betaine anhydrous, also known as trimethylglycine, is a naturally occurring compound originally isolated from sugar beets and found in foods like wheat germ, spinach, and wheat bran. At 2500mg per serving, Hosstility RTD provides the clinically-researched dose that has consistently shown performance benefits in multiple studies.

  This versatile compound functions in dual roles in human physiology: as a methyl donor in homocysteine metabolism and as an organic osmolyte that helps maintain cellular hydration under stress.^[7] Research demonstrates that betaine supplementation can significantly improve both strength and power output, making it an ideal addition to high-intensity training protocols.^[8,9]

  The performance benefits of betaine become evident through several mechanisms. As an osmolyte, betaine helps maintain cell volume and function during intense exercise by stabilizing proteins and enzymes under physiological stress. This cellular protection supports optimal excitation-contraction coupling in muscle fibers, enabling sustained power output during demanding training sessions.

  Clinical research has consistently shown that betaine supplementation at 2.5g daily can enhance bench press power, vertical jump performance, and overall training volume.^[8,9] Additionally, betaine may support favorable hormonal responses to training, including improvements in testosterone-to-cortisol ratios during competitive periods.

  The 2500mg dose in Hosstility RTD aligns with the most research protocols, providing users with a scientifically validated amount that can genuinely impact training performance. When combined with the other performance ingredients in this formula, betaine contributes to the comprehensive approach that defines serious pre-workout supplementation.

• Acetyl L-Tyrosine – 2000mg

  

  L-tyrosine is the precursor to several critical neurotransmitters, including dopamine, norepinephrine, and epinephrine (collectively known as catecholamines). These neurotransmitters play essential roles in cognitive function, mood regulation, stress response, and physical performance. However, Hosstility RTD uses the acetylated form, Acetyl L-Tyrosine, which offers superior stability in liquid formulations compared to standard L-tyrosine.

  The acetyl group attached to L-tyrosine enhances its solubility and prevents degradation in ready-to-drink products, making it the preferred choice for RTD pre-workouts. While regular L-tyrosine is only moderately soluble in water and can present formulation challenges in liquid products, NALT maintains its potency throughout the product’s shelf life.^[10]

  Research demonstrates that tyrosine supplementation becomes most beneficial during periods of acute stress, when catecholamine demands increase significantly. For instance, tyrosine can help maintain cognitive performance under stressful conditions such as cold exposure, sleep deprivation, and intense physical demands. The mechanism centers on tyrosine’s role as a rate-limiting substrate for tyrosine hydroxylase, the enzyme responsible for converting tyrosine into L-DOPA, which then becomes dopamine and subsequently norepinephrine.^[11]

  At 2000mg per serving, Hosstility RTD provides a substantial dose that can support focus and mental clarity during demanding training sessions. This dosage falls within the range used in clinical studies, where effective doses typically ranged from 100-150mg per kilogram of body weight. The timing of consumption is important, as research indicates tyrosine’s effects are realized approximately 60-300 minutes after ingestion, with plasma levels peaking around 120 minutes post-consumption.

• Taurine – 2000mg

  Taurine is a sulfur-containing amino acid that plays crucial roles in multiple physiological processes, making it a valuable addition to pre-workout formulations. At 2000mg, Hosstility RTD provides a clinically-relevant dose that can enhance both performance and recovery mechanisms.

  

  Hosstility AMPED is Hosstile Supplements’ monster-grade pre-workout supplement, featuring 450mg total caffeine and 250mg Cognizin citicoline!

  One of taurine’s primary (and understated) benefits at this dose lies in its ability to improve fat oxidation during exercise. Research demonstrates that taurine supplementation can increase fat metabolism by up to 16% during prolonged exercise, achieved through activation of adenylate cyclase and cyclic adenosine monophosphate (cAMP) pathways.^[12,13] This metabolic shift allows for more efficient fuel utilization and may enhance endurance capacity.

  Taurine also supports muscle function through its role in calcium homeostasis. The amino acid assists with calcium handling in both Type I and Type II muscle fibers, promoting enhanced calcium release and uptake that’s essential for optimal muscle contraction and force production.^[14] This mechanism contributes to improved contractile properties and may help maintain performance during high-intensity training sessions.

  Beyond performance enhancement, taurine offers protective benefits through its antioxidant properties. The compound helps reduce exercise-induced oxidative stress and may support faster recovery by minimizing cellular damage from reactive oxygen species. Additionally, taurine’s role in mitochondrial function supports the biochemical processes essential for energy production, including the citric acid cycle and fatty acid oxidation pathways.

  The 2000mg dose in Hosstility RTD falls within the effective range established in research studies (including an important endurance meta-analysis^[15]) and provides sufficient availability to support these multiple physiological functions during training.

• Cognizin® Citicoline – 250mg

  Cognizin® Citicoline stands out as the most impressive inclusion in Hosstility RTD, representing a significant upgrade from the basic choline sources found in most pre-workout formulas. This patented^[16-19] form of citicoline from Kyowa Hakko delivers noticeable cognitive benefits that complement the physical performance aspects of your training session.

  

  Cognizin® Citicoline is dubbed the The Brain Choline not just because it provides choline, but because it also supplies cytidine, which is also needed for the synthesis of phosphatidylcholine

  Why citicoline beats regular choline

  Unlike standard choline bitartrate or choline chloride that many users can’t “feel” as well, citicoline (cytidine-5′-diphosphocholine or CDP-Choline) provides a dual-action approach to brain support.^[20] When you take Cognizin®, it’s rapidly absorbed and broken down in your intestinal wall into choline and cytidine, with the cytidine being further converted to uridine. Both choline and uridine then cross the blood-brain barrier, where uridine is converted to uridine triphosphate and then cytidine triphosphate, which combines with phosphorylated choline to resynthesize citicoline specifically within brain tissue!^[21]

  This unique metabolic pathway explains why citicoline feels different from other choline sources. The uridine component provides additional nucleotide support for brain cell membranes and energy metabolism, while the choline portion supports acetylcholine production for focus and attention. The result is a more comprehensive approach to cognitive support that goes beyond simple choline supplementation.

  Clinical research at the 250mg dose

  The 250mg dose of Cognizin in Hosstility RTD aligns perfectly with clinical research demonstrating significant cognitive benefits. In a double-blind, placebo-controlled study with healthy adult women, 250mg of citicoline daily for 28 days significantly improved attentional performance compared to placebo.^[22] The study used the Continuous Performance Test II (CPT-II), which measures sustained attention and response inhibition — critical factors for maintaining focus during intense training sessions.

  The results were impressive: participants taking 250mg citicoline made fewer omission errors (failing to respond when they should) and commission errors (responding when they shouldn’t). They also showed improved reaction time consistency, indicating better sustained attention throughout the testing period. For athletes and lifters, this translates to better mind-muscle connection, improved form maintenance, and reduced mental fatigue during challenging workouts.

  Neurotransmitter support for training focus

  

  Images courtesy Kyowa Hakko, the sponsor of this article

  Cognizin’s benefits extend beyond basic attention improvement through its effects on multiple neurotransmitter systems. Research shows that citicoline supplementation helps maintain healthy levels of acetylcholine, dopamine, and norepinephrine.^[23] This multi-pathway approach creates a more potent cognitive enhancement effect compared to ingredients targeting single neurotransmitter systems.

  The dopamine support aspect is worth highlighting for pre-workout applications. Dopamine plays a crucial role in motivation, reward processing, and motor control… all essential elements for productive training sessions. While many pre-workout supplements rely solely on stimulants for motivation, Cognizin provides a complementary pathway that supports natural drive and focus without additional stimulation.

  Membrane support for long-term brain health

  Beyond acute cognitive benefits, Cognizin supports the structural foundation of brain cells through enhanced phospholipid metabolism. Clinical research using phosphorus magnetic resonance spectroscopy shows that chronic citicoline supplementation increases brain phosphodiesters, indicating enhanced phospholipid synthesis and turnover.^[24]

  This mechanism is important for athletes because intense training creates oxidative stress that can affect brain cell membranes. Cognizin helps support the body’s natural membrane repair and maintenance processes, potentially contributing to long-term cognitive health alongside your physical training adaptations.

  An Incredible Breadth of Research

  Citicoline has so much research on it, there are numerous claims that can be definitively stated about it:

  

  • Accuracy (250mg/day):
    • Cognizin® helps improve accuracy and reduce errors while on task^[22,25,26]
  • Focus & Attention (250mg/day):
    • Cognizin® helps support concentration and helps improve focus and attention^[22,26,27]
    • Cognizin® helps your ability to stay focused, supporting staying on task^[22,26,27]
  • Productivity (250mg/day):
    • Cognizin® helps support productivity through focus, reaction time, and accuracy^[22,25-28]
  • Phospholipids (250mg/day):
    • Cognizin® supports phosphatidylcholine production and phospholipid metabolism in the brain^[21,24,27]
  • Cognitive Health
    • Cognizin® supports brain and cognitive health^{[22,26,28-31]}
  • Brain Health
    • Cognizin® provides daily support for brain health^[27,30] and supports healthy brain cell signaling, brain DNA synthesis, and repair^[20,21,32]
  • Neurotransmitter Levels
    • Cognizin® helps maintain healthy neurotransmitter levels, supporting acetylcholine, dopamine, and norepinephrine levels^[21]
  • Long-Term Brain Health
    • When taken daily, Cognizin® supports long-term brain health^[27,30]

  So the 250mg dose represents the sweet spot for pre-workout applications. This makes Hosstility RTD an excellent choice for athletes who want noticeable cognitive enhancement alongside their physical performance ingredients, all in a convenient ready-to-drink format that fits busy training schedules and is still quite affordable.

  You can read more in our main article, “Cognizin® Citicoline: The Brain Choline“.

• Himalayan Pink Salt – 250mg

  

  Kyowa Hakko USA earns 4th patent for Cognizin Citicoline, further validating visual attention & cognitive performance benefits. New IP covers methods for enhancing attention, motor function & processing speed.

  While often overlooked in pre-workout formulas, salt serves a critical role in maintaining optimal hydration and performance during intense training sessions. This natural sodium source helps maintain electrolyte balance, supports muscle contractions, and aids in nutrient absorption.

  The 250mg dose provides approximately 100mg of sodium, which becomes essential during high-intensity workouts when sweat rates increase significantly. Research shows that sodium losses through sweat can range dramatically between individuals, with some athletes losing over 1,000mg of sodium per hour during intense exercise.^[33] Rather than waiting until after your workout to replace these losses, including sodium in your pre-workout helps maintain fluid balance from the start.

  Beyond hydration support, sodium also enhances the absorption of other key ingredients like citrulline and enhances the “pump” effect that many pre-workout users seek.

• Caffeine Anhydrous – 200mg (of 300mg total caffeine)

  At 300mg total caffeine per bottle, Hosstility RTD delivers a substantial stimulant dose that’s strategically split between two different forms for optimal timing and sustained energy. The bulk of this comes from 200mg of caffeine anhydrous, the most researched and reliable form of caffeine supplementation.

  Caffeine exerts its primary ergogenic effects through central nervous system stimulation, working as an adenosine receptor antagonist to increase neurotransmitter release, enhance motor unit firing rates, and reduce perceived exertion during exercise.^[34] This mechanism translates to measurable performance benefits across multiple exercise modalities, including enhanced endurance performance, improved high-intensity exercise capacity, and increased strength-power output.

  

  Danielle Citrolo of Kyowa Hakko USA joins PricePlow Podcast Episode #153 and discusses groundbreaking new gene research on Cognizin Citicoline and its potential for supporting brain health and cognitive function.

  Beyond its performance-enhancing effects, caffeine also provides significant thermogenic benefits. Research demonstrates that caffeine consumption produces a notable increase in energy expenditure that can persist for hours post-consumption, making it valuable for both training intensity and metabolic enhancement.^[35]

  Dicaffeine Malate – 133mg (yielding 100mg caffeine)

  The remaining 100mg of caffeine comes from dicaffeine malate, a bonded form of caffeine that may provide a more sustained release profile compared to standard caffeine anhydrous. This dual-caffeine approach is designed to deliver both immediate stimulation from the anhydrous form and extended energy support from the malate-bonded caffeine, potentially extending the performance window and reducing the likelihood of an energy crash.

  Total caffeine content: 300mg per bottle

Flavors Available

Hosstility RTD launched with three flavor options designed to deliver refreshing taste without artificial colors or dyes. Here are the available flavors:

Conclusion: RTD With Cognizin… and Without Compromise

Katie Emerson and Tony Miano of Kyowa Hakko join PricePlow to discuss the latest Cognizin and Setria research developments at Expo West 2025 in Episode #163.

Hosstility RTD proves that ready-to-drink pre-workouts don’t have to sacrifice performance for convenience. With clinical doses of proven ingredients like L-citrulline, glycerol, and Cognizin®, this formula delivers the same intensity you’d expect from a premium powder… just without the mixing.

As we recently discussed with Katie Emerson and Tony Miano from Kyowa Hakko on Episode #163 of the PricePlow Podcast, the citicoline’s body of research continues to expand, with new studies examining its effects on mood, motor function, and sports performance. Having this premium nootropic in an RTD format makes it more accessible for athletes who want cognitive enhancement alongside their physical training benefits.

For those who’ve been waiting for an RTD that doesn’t compromise on ingredient quality or dosing, Hosstility RTD delivers. It’s the same relentless approach to supplementation that Fouad Abiad built his brand on, just in a format that travels with you.

Ready to experience the difference that proper dosing makes? Use our price comparison tool below to find great deals on Hosstility RTD, or head right to Hosstile’s site directly: