Unmatched Supps Longevity Sleep: Peptide-Powered Sleep Formula for Recovery and Health Span

Unmatched Supps Longevity Sleep features 250mg PeptiSleep™ (AI-discovered peptide from Nuritas), 3g glycine, 3g GABA, tart cherry, Senactiv, and ZMA. Multi-pathway approach helps you fall asleep faster, stay asleep longer, and wake up recovered.

Sleep isn't just downtime between training sessions. It's when your body repairs tissue, consolidates memory, balances hormones, and clears metabolic waste that accumulates during waking hours. Yet quality sleep remains elusive for many athletes and driven individuals who push hard during the day but struggle to downshift at night.

Unmatched Supps Longevity Sleep addresses this challenge with a comprehensive formula built around 250mg of PeptiSleep™, a clinically-studied plant-based peptide from Nuritas that enhances deep sleep architecture at the cellular level -- and this is our first time covering the novel ingredient made by the creators of PeptiStrong. Longevity Sleep isn't a knockout sedative that leaves you groggy, though. It's a multi-pathway system engineered to help you fall asleep faster, stay asleep longer, and wake up genuinely recovered.

Longevity Sleep: More Than Sleep Support

The formula layers traditional sleep aids like 3g glycine and 3g GABA with targeted recovery compounds including tart cherry extract and Senactiv®, a senolytic blend that supports cellular renewal. A clinical-strength ZMA blend (zinc, magnesium, B6) anchors hormone production and nervous system function, while 3mg melatonin helps reset circadian timing without excessive dosing.

This approach mirrors the incredible philosophy we've seen throughout the Unmatched lineup. Just as Longevity Multi delivers seven targeted formulas for total health optimization and Longevity Test addresses hormonal support from multiple angles, Longevity Sleep tackles rest and recovery as a complex system requiring more than a single ingredient.

True to Unmatched's standards, the formula uses only natural sweeteners and flavors with no artificial colors or dyes. Many users report excellent results with just half a scoop, making this a flexible option that you can titrate based on your individual sleep needs.

Subscribe to PricePlow's Unmatched Supps news and check availability below, and then let's get into the science:

Unmatched Supps Longevity Sleep Ingredients

Each serving (1 scoop, 14g) provides the following:

• L-Glycine - 3000mg

  Glycine functions as both an inhibitory neurotransmitter in the peripheral and central nervous systems and as a co-agonist at NMDA glutamate receptors.^[1] This dual action creates unique sleep-promoting effects that differ fundamentally from traditional sedatives.

  Research demonstrates that 3g glycine taken before bed significantly reduces sleep onset latency and time to slow-wave sleep without altering sleep architecture.^[2] Unlike benzodiazepines that modify sleep stages and can impair next-day function, glycine preserves natural sleep cycles while subjectively improving sleep satisfaction and efficiency.

  The mechanism involves glycine's action on NMDA receptors in the suprachiasmatic nucleus (SCN), the brain's circadian control center.^[1] This triggers peripheral vasodilation and a small decrease in core body temperature, mimicking the natural physiological transition to sleep.^[3]

  Studies in sleep-restricted individuals show glycine reduces daytime sleepiness and fatigue while improving cognitive performance the following day.^[3] The 3g dose in Longevity Sleep matches the clinically validated amount used across multiple human trials.

  Massive Dose Alert: There's Even More in the Magnesium Glycinate!

  Worth noting is that we have 450 milligrams of magnesium coming from magnesium glycinate in here. Since Magnesium glycinate is actually around 90% glycine, this means we have another 4 grams of glycine here, bringing our total to 7g! This is one reason why half of a scoop of Longevity Sleep has been so effective for so many.

• GABA (Gamma-Aminobutyric Acid) - 3000mg

  

  GABA is the brain's primary inhibitory neurotransmitter, responsible for calming neural activity and promoting relaxation. Research shows that oral GABA supplementation shortens sleep latency (the time it takes to fall asleep) while increasing total non-REM sleep time.^[4]

  Studies using 100mg of GABA demonstrated meaningful improvements in sleep onset,^[4] making the 3000mg dose here a robust approach. GABA activates GABA receptors in the nervous system, reducing neuronal excitability and helping transition from waking to sleep.^[5]

  The compound is quickly absorbed, with blood levels peaking around 30 minutes after intake,^[4] aligning with recommended pre-bed timing. Research suggests synergistic effects when GABA is combined with other sleep-supporting compounds,^[5] making it a strategic component in this comprehensive formula.

• L-Tryptophan - 1500mg

  L-Tryptophan is an essential amino acid that serves as the metabolic precursor to both serotonin and melatonin, two compounds central to sleep architecture and circadian regulation.^[6] The conversion pathway begins when tryptophan hydroxylase converts tryptophan to 5-hydroxytryptophan, the rate-limiting step in serotonin synthesis. This enzyme operates below substrate saturation under normal conditions, meaning increased brain tryptophan levels directly enhance serotonin production.^[7]

  Serotonin then converts to N-acetyl-5-HT and ultimately melatonin in the pineal gland, establishing the neurochemical foundation for healthy sleep-wake cycles. Research demonstrates that elevated tryptophan intake improves sleep efficiency, extends sleep duration, and reduces anxiety and depression symptoms.^[8]

  

  The 1500mg dose in Longevity Sleep provides substantial substrate availability when your body needs to transition from wakefulness to deep, restorative sleep.

• Tart Cherry Extract 4:1 (Prunus cerasus) (Fruit) - 500mg

  Tart cherry brings dual benefits to this sleep formula: supporting the body's recovery processes overnight while contributing naturally-occurring compounds that complement the formula's sleep-promoting ingredients.

  The 500mg of 4:1 extract (equivalent to 2000mg of raw fruit) delivers concentrated anthocyanins and phenolic compounds that address inflammation and oxidative stress.^[9] These bioactive compounds reduced markers of inflammation in 11 of 16 human studies and decreased oxidative stress in 8 of 10 studies reviewed.^[9]

  Most relevant for nighttime recovery: tart cherry consumption reduced exercise-induced muscle soreness and loss of strength in 8 of 9 studies.^[9] The primary anthocyanins (cyanidin-3-glucoside and cyanidin-3-rutinoside) work by inhibiting cyclooxygenase enzymes and modulating inflammatory pathways.^[9]

  While tart cherries contain small amounts of naturally-occurring melatonin, the inflammation and recovery benefits drive their inclusion here. Combined with this formula's senolytic ingredients and hormonal support, tart cherry helps optimize the cellular repair processes that occur during deep sleep.

• PeptiSleep™ Rice (Oryza sativa) Protein Hydrolysate - 250mg

  PeptiSleep™ brings a fundamentally different approach to sleep support: AI-discovered plant peptides from brown rice that work at the cellular level to support healthy cortisol patterns.

  

  While most sleep aids focus on sedation or relaxation, PeptiSleep addresses a root cause of poor sleep: elevated evening cortisol. This stress hormone keeps you alert when you should be winding down. By targeting orexin receptors involved in cortisol release, PeptiSleep may help support the body's natural transition into restorative sleep without affecting morning cortisol levels (meaning no grogginess upon waking).

  Forthcoming clinical research on PeptiSleep used validated sleep questionnaires and biometric tracking devices to measure real-world effects. Participants taking 250mg saw improvements across all four measured domains of sleep quality: falling asleep, staying asleep, ease of waking, and next-day function. The biometric data revealed 12 additional minutes of REM sleep, 13 more minutes of deep sleep, and 38 more total minutes of sleep compared to placebo. Heart rate variability increased by 32%, indicating enhanced parasympathetic nervous system activity and improved recovery.

  Unlike melatonin-based approaches that primarily address sleep onset, PeptiSleep supports the entire sleep architecture through its cortisol-modulating mechanism. The 250mg dose used here matches the clinically-studied amount shown on ClinicalTrials.gov, taken 30-60 minutes before bed.

  The above data is not yet published as of early 2026, but Nuritas has been talking about it, and we'll have more information as soon as it's available.

  Nuritas founder Nora Khaldi discussed their AI-driven peptide discovery process in detail on Episode #198 of the PricePlow Podcast, explaining how their technology identified these specific bioactive peptides from over 9 million plant peptide sequences.

• Valerian Root Extract 4:1 (Valeriana officinalis) (Root) - 200mg

  

  Valerian has served as a traditional sleep aid for centuries, but modern research validates multiple mechanisms behind its effectiveness. The 200mg of 4:1 extract (equivalent to 800mg raw root) delivers concentrated bioactive compounds including valerenic acid, valepotriates, and naturally-occurring GABA.^[10]

  Valerian works through dual pathways. Its lignan derivatives act as partial agonists at adenosine A1 receptors in the forebrain, reducing excitatory neurotransmission and increasing the homeostatic drive for sleep.^[11] Simultaneously, valerenic acid and other constituents modulate GABA channel activity, enhancing inhibitory neurotransmission.^[12]

  Clinical trials demonstrate valerian reduces sleep latency while increasing slow-wave sleep, the deep restorative phase critical for physical recovery and cellular repair.^[11] Combined with this formula's neurotransmitter precursors and hormonal support, valerian addresses multiple barriers to quality sleep.

• Senactiv® (Panax notoginseng (Root) and Rosa roxburghii (Fruit) Extracts) - 50mg

  Senactiv is a senolytic compound that clears aged, dysfunctional cells from muscle tissue to make room for cellular renewal.^[13] This proprietary blend of Panax notoginseng and Rosa roxburghii addresses a recovery bottleneck that accumulates during hard training: senescent cells that resist normal clearance and contribute to inflammation.

  In human resistance exercise studies, ginsenoside Rg1 (the active component in Senactiv) reduced muscle inflammation markers including p16^INK4a^ mRNA expression by 65% compared to placebo, while also lowering neutrophil markers 24 hours post-exercise.^[14] The same research showed that Rg1 prevented the depletion of muscle satellite cells during recovery, supporting the tissue repair processes that occur during sleep.

  

  By accelerating senescent cell clearance and reducing exercise-induced inflammation, Senactiv helps optimize the cellular repair and renewal that define quality recovery. For athletes pushing hard during waking hours, this supports the body's natural cleanup and restoration mechanisms during sleep.

• Melatonin - 3mg

  Melatonin serves as the body's primary circadian regulator, with natural production peaking 1-2 hours before sleep onset. Supplemental melatonin addresses the circadian disruption and declining endogenous production that occurs with age, stress, and irregular schedules.

  The 3mg dose aligns with research demonstrating peak efficacy between 3-4mg daily for reducing sleep onset latency and increasing total sleep time.^[15] Meta-analysis confirms that 3mg significantly outperforms lower doses, with timing playing a critical role in effectiveness.^[15] Taking melatonin 30-60 minutes before bed capitalizes on data showing that administering it 2-3 hours before sleep maximizes the circadian signal.^[15]

  Beyond sleep initiation, melatonin improves overall sleep quality through thermoregulation, MT1/MT2 receptor activation in the suprachiasmatic nucleus, and modulation of circadian clock genes.^[16] The compound shows a benign safety profile with no habituation or tolerance, making it suitable for consistent use.^[17]

• Vitamin B6 (as Pyridoxine HCl) - 10mg

  Vitamin B6 anchors the ZMA component of this formula by supporting multiple pathways essential for recovery and sleep quality. Its active form, pyridoxal-5'-phosphate, functions as a cofactor for enzymes that convert tryptophan into serotonin and subsequently melatonin, directly supporting the neurotransmitter cascade that drives sleep architecture.^[18]

  

  Beyond neurotransmitter synthesis, B6 facilitates amino acid metabolism and energy production pathways active during overnight recovery.^[19] This includes supporting glycogenolysis and gluconeogenesis while helping regulate ammonia metabolism, processes that become crucial when your body shifts from waking activity to restorative sleep states.^[20]

  The 10mg dose (588% DV) works synergistically with zinc and magnesium to optimize hormonal production and nervous system function throughout the sleep cycle.

• Magnesium (as Magnesium Glycinate) - 450mg

  Magnesium serves as the central nervous system's natural brake pedal. As a cofactor in over 600 enzymatic reactions,^[21] the mineral regulates neurotransmitter activity by modulating GABA receptors and acting as a natural NMDA receptor antagonist.^[21] This dual action helps quiet neural excitation while supporting the inhibitory pathways that facilitate sleep onset.

  Clinical research demonstrates that magnesium supplementation improves both subjective sleep quality and objective polysomnographic measurements in adults.^[22] The mechanism appears linked to magnesium's ability to lower cortisol levels and normalize circadian rhythms.^[23]

  The glycinate form offers superior bioavailability compared to magnesium oxide, with the amino acid chelate protecting the mineral during digestion and enabling absorption through both mineral and amino acid transport pathways.^[24] The bound glycine also contributes its own calming effects, creating a synergistic sleep support system.

  

  Unmatched Supps Longevity Multi+ is a 7-packet daily system that makes your average multivitamin look like child's play. We're talking clinical doses of everything from Spectra antioxidants to spermidine for cellular longevity.

  Again, note that this adds to our already-clinically-dosed glycine total, bringing it to around 7g worth in a scoop!

• Zinc (as Zinc Monomethionine) - 30mg

  Zinc anchors this formula's hormonal support system, working alongside magnesium and B6 as part of the research-backed ZMA complex. Your body produces the majority of anabolic hormones during deep sleep, making zinc availability critical during this recovery window.

  The zinc monomethionine form used here binds zinc to the amino acid methionine, creating a complex your small intestine absorbs far more efficiently than cheaper forms like zinc oxide.^[25] The methionine acts as a transport mechanism, essentially "smuggling" zinc into your bloodstream alongside amino acid absorption.

  Research demonstrates that zinc supplementation supports testosterone levels in both sedentary individuals and athletes who train to exhaustion,^[26] while also influencing thyroid hormone production (T3 and T4).^[26] Beyond hormones, zinc functions as an antioxidant and supports the immune system, both critical for overnight cellular repair and recovery processes.

Flavors Available

Here's an up-to-date list of all flavors of Unmatched Supps Longevity Sleep:

How to Use

Unmatched Supps Longevity Test targets testosterone optimization through 8 clinically-dosed ingredients. KSM-66 Ashwagandha, Furosap, Tongkat Ali, and apigenin work together to support natural test production while managing cortisol and estrogen.

• When to take it: Mix one scoop with 8-12oz of water and consume 30-60 minutes before bed.
• Dosing flexibility: Many users get excellent results with half a scoop. Start with a half serving to assess your response, then adjust as needed. The formula is potent.
• With or without food: Can be taken with or without food, though taking it on an empty stomach may promote faster onset.
• Other notes: Avoid driving or operating machinery after consumption. For best results, maintain a consistent sleep schedule and create an environment conducive to rest.

Stacks Well With

• Longevity Multi: The foundational health system provides the vitamins, minerals, and cellular support that optimize recovery processes during sleep. Quality sleep and complete nutrition create a synergistic foundation for long-term health.
• Longevity Test: Natural testosterone support and better sleep quality reinforce each other. Deep sleep is when your body produces the majority of anabolic hormones, making these formulas natural partners for anyone focused on hormonal optimization.

Who It's For

• Athletes and hard trainers: If you're pushing your body hard during the day but struggling to downshift at night, Longevity Sleep addresses the neural and hormonal factors that prevent quality rest.
• Shift workers and frequent travelers: The melatonin and circadian-supporting ingredients help reset your internal clock when schedules are disrupted.
• Anyone prioritizing longevity: Deep, restorative sleep is the foundation of cellular repair, cognitive function, and metabolic health. This formula supports the sleep architecture that drives health span.

Conclusion: Sleep as a Performance Strategy

Nora Khaldi, founder and CEO of Nuritas, discusses AI-powered peptide discovery, clinical validation, and the science behind PeptiStrong, PeptiSleep, PeptiYouth, and PeptiControl on Episode #198 of the PricePlow Podcast.

Unmatched Supps Longevity Sleep represents a departure from single-mechanism sleep aids that simply knock you out. By combining PeptiSleep™'s cellular-level support with multiple complementary pathways including neurotransmitter modulation, hormonal optimization, and circadian alignment, this formula addresses sleep as the complex biological process it is.

The inclusion of recovery-specific ingredients like tart cherry extract and Senactiv® reflects Unmatched's commitment to formulas that serve both immediate performance and long-term health. This isn't just about feeling rested tomorrow. It's about optimizing the repair and renewal processes that occur during sleep to support sustained vitality and health span.

For those already using the Longevity Multi or Longevity Test, adding Longevity Sleep completes the foundation for total health optimization. When your nutrition, hormones, and sleep quality are all dialed in, you create the conditions for peak performance and longevity.

Kris Gethin consistently emphasizes that sleep is your number one tool for longevity, outpacing any biohacking gadget or technology. Longevity Sleep gives you the ingredients and dosages to make that nightly recovery window as effective as possible.