Metanabol: ALR’s Multi-Faceted Prohormone

ALR Industries Metanabol

Metanabol for ALR Industries is a powerful anabolic agent that uses four different prohormones alongside a testosterone support complex to maximize gains.

While the ongoing battle over stimulants like DMAA grab the biggest headlines, there’s no getting around it, 2016 is the re-birth year of prohormones. They’ve literally exploded onto the scene in a big way, and can be found in a number of different companies products.

The latest round of legal prohormones are led by the Hi-Tech Pharmaceuticals family, and one brand that they own is ALR Industries, who have an aggressive new “general purpose” prohormone named Metanabol.

As with all prohormones, the same rules are going to apply:

  • Experienced users only – ages 23 and up suggested
  • Post Cycle Therapy (PCT) is required
  • Aromatase Inhibitor (AI) is required (due to the 4-andro inside)
  • Blood tests are required before, during, and after your cycle
  • On cycle therapy support supplement highly suggested

While these may be marketed as supplements, but they’re not “simple” ones – they require your research and respect – and with that can come some serious gains that you’d otherwise not be able to get for years.

You can read more about the various ingredients below, but first, take a moment to check the best deal and sign up for PricePlow alerts:

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Metanabol Ingredients

Metanabol’s ingredient list reads like a prohormone lover’s wet dream. You get not one, not two, not three, but FOUR different prohormones all wrapped up in one tablet. There’s more though, there’s also a Testosterone Support System complex to further help boost your libido and muscle-building desires

  • Prohormone Blend (1000mg)

    • 1-androsten-3b-ol-17-one

      Metanabol Ingredients

      Metanabol includes powerful prohormones like 1-Andro and 4-Andro to elevate your anabolic potential to unseen heights.

      Although third on the label, the primary prohormone in Metanabol is also known as 1-Andro or 1-DHEA. We’ll present an overview of its effects in the body, but if you want to get really deep into its MOAs, consult our in-depth guide titled: . 1-Andro / 1-Androsterone / 1-DHEA: 2016’s Prohormone.

      In the body, 1-Andro does the Texas Two Step and goes a two part conversion. First, it converts to 1-Androstenediol and then converts to 1-Testosterone, the target anabolic. Like with 4-Andro, this multi-step process could technically classify 1-Andro as a pre-prohormone.

      That’s great and all, but what does it do?

      Fortunately for you, there’s actual research behind the gains you will reap with this ingredient. A research trial conducted at Texas A&M in 2013 enlisted 17 men aged 18-35. The subjects consumed a total of 330mg 1-DHEA, split into 3 equal doses, each day for four weeks.[3]

      Following the four weeks, the men’s lean mass was significantly increased, while fat was significantly decreased! The graphs from the study show that on average, lean mass grew from 74kg to roughly 78.5kg, basically a 10 pound gain in muscle!

      Additionally, the group experienced significant gains in the BIG 3 (i.e. squats, bench, and deadlifts). They were all statistically significant, but the back squat showcased the greatest improvement — increasing from about 360lbs to 405!

      Now, we don’t know the dosage of 1-Andro in Metanabol, so don’t expect to see a 10 pound gain in muscle mass while using this, but you should still see some significant growth and improvement on your big 3 lifts.

    • 4-androsten-3b-ol-17-one

      Steroidal Hormone Principle Pathways

      While Androstenediol (4-AD) definitely converts to testosterone, Andtrostedione also makes its way to estrogen! This is why an Aromatase Inhibitor and blood tests are so critically important whenever touching 4-Andro

      Next to 1-Andro, this is the next ingredient where the money’s made: 4-Andro.

      4-Andro is one of the popular legal prohormones of 2016 — It takes a two-stage conversion process to make its way to actual testosterone in your system!

      It does this by converting to both 4-androstenedione (Andro Dione) and 4-androstenediol (Andro Diol — also known as 4-AD) via the 3-hydroxysteroid dehydrogenase and 17-hydroxysteroid dehydrogenase enzymes, respectively.

      4-AD is the heavy hitter here — it’s what we’re going for, and is the prohormone that was banned in 2005, amongst other great prohormones like 1-AD (which we’ll get to in the next section using 1-Andro).

      Why is 4AD awesome? Because 4-AD converts to testosterone! This is done via the 3 beta hydroxysteroid dehydrogenase enzyme. With this, 4-Andro adds a “testosterone base” to your prohormone stack, and will easily boost your testosterone levels, and help yield many of the anabolic and masculating properties that users want.

      But when using 4-Andro, there’s a catch:

      4-androstenedione (Andro Dione) converts more easily to estrogen
      ALR Metanabol

      This is a big boy supplement for experienced users!

      Unfortunately, any time we’re dealing with testosterone, we’re also going to deal with increased estrogen levels. And to top it off, when 4-Andro converts to both 4-androstenediol and 4-androstenedione, the dione part readily converts to estrogen more so than testosterone.

      Because of this, it is critically important to take an aromatase inhibitor and get blood tests when using Metanabol! It is also necessary to see a doctor, preferably an endocrinologist, anytime you’re considering hormonal-based supplements.

      A common AI is arimistane, or Androsta-3,5-diene-7,17-dione, but the truth is that only blood tests will tell you if it is strong enough and keeping estrogen levels down enough. There is unfortunately no human-based research on this AI. Thankfully, this is one of the ingredients in the on cycle support supplement we suggest, Olympus Labs Ar1macare Pro.

      If that’s not enough per your blood tests, then see the aromatase inhibitors section of our post cycle therapy article for stronger suggestions that are prescription-based with your endocrinologist’s opinion.

      Over time, we hope to get blood tests to see how strong both 4-Andro and Arimistane are. See the PricePlow blood testing program for more information.

      In summary, 4-Andro is the ingredient that brings the libido, confidence-like energy, and testosterone-driven effects to your Metanabol cycle, while 1-AD brings the most proven gains itself.

    • Androsterone

      This is actually first on the label, meaning it’s the highest (or equal) dosed.

      Androsterone, a.k.a 3α-hydroxy-5α-androstan-17-one, is often confused with 1-Androsterone, but the two are completely different compounds (1-DHEA discussed first in this list). Although both are related to DHEA, Androsterone a metabolite of DHEA by way of androstenedione/testosterone/DHT. Plus, Androsterone is naturally occurring.

      To better understand exactly what Androsterone does, it’s best to consult Thomas Scott’s book, Concise Encyclopedia Biology, where he states that,

      ”Androsterone, 3α-hydroxy--androstan-17-one: an Androgen which is formed in the interstitial cells of the testes. Its androgenic potency is 7 times less than that of testosterone, but it is used as the international reference standard for androgenic activity: 1.0 international unit (IU) corresponds to 0.1mg A.A. is excreted in urine as a metabolic product of testosterone.”[1]

      Notice that he uses 3α-hydroxy--androstan-17-one as opposed to 3α-hydroxy--androstan-17-one which is used in ALR’s Metanabol, so there might be a slight difference in its effects, but the anabolic potential is still there.

      Additionally, Androsterone possesses some other unique effects in that it can get converted to dihydrotestosterone (DHT) via 3α-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase.[2]

    • Androstenolone Acetate

      1-Andro Results

      These are some serious lean mass gains — as in TRUE steroid-like gains. But note that this is a ‘harsher’ dose than what’s in Metanabol, so you may need to set more realistic expectations.

      Androstenolone acetate is a fast-acting ester of Androstenolone, hence the “acetate” component of the ingredient name. Basically, Androstenolone Acetate = DHEA acetate ester.

      Although lacking substantial research, Androstenolone acetate is said to be beneficial in promoting lean mass (i.e. muscle) gain. In general, compounds like this (prohormones) help synthesize new muscle cells due to increased protein synthesis abilities. This in turn increases the body’s utilization of amino acids and helps spur new muscle growth.

      Anecdotally, DHEA works best in older guys aged 50+. This helps round out Metabanol for all kinds of users.

  • Proprietary Testosterone Support System (600mg)

    • Fenugreek 90% Furostanol Saponin Extract (seed)

      Fenugreek has long been used in traditional medicine as an all-natural means of boosting virility and libido. Research using Fenugreek as an effective testosterone booster is somewhat mixed though. The big study everyone points to its usefulness shows it was able to successfully raise testosterone while simultaneously reducing body fat. decrease in body fat within test group.[4]

      Fengreek seems to operate as an alpha-5 reductase inhibitor, which limits the conversion of testosterone to dihydrotestosterone (DHT). However, to truly see these effects you’ll need to use a dose of at least 500mg, as pointed out in clinical trials.[5] Since this is the first of four ingredients in a 600mg blend, chances are you’re not getting that much.

      In the end though, Fenugreek may mildly boost testosterone by simply helping you not lose as much testosterone to its much less useful DHT counterpart.

      Note that Fenugreek does not alter estrogen levels,[12,13] despite the way that it’s sometimes marketed, so you’ll still need an AI to support the 4-Andro.

    • Anacyclus pyrethrum DC 200:1 petroleum ether extract

      Anacyclus Pyrethrum

      Staying natty? What’s more natural than this? (Image Courtesy Wikimedia)

      Anacyclus pyrethrum, a.k.a. Akarkara, is an Aphrodisiac herb commonly used in Ayurveda to boost male vitality. In terms of research, there’s not much in the way of human tests, but there are several using animals.

      In those trials, Anacyclus pyrethrum was able to elevate testosterone levels, improve sperm motility, enhance libido, and increase testicular weight.[6,7]

      This is definitely one of the over-the-counter, natural supplements that we’d love to get some human-based blood tests for. It’s been popular ever since it was announced in the PES Anabeta supplement, but we’ve never confirmed if it truly boosts testosterone in humans. Even if it doesn’t… it definitely seems anabolic though, given years of great reviews!

    • Massularia Acuminata 200:1  Aqueous extract

      We’re not done with our herbal constituents yet. Next up is a Nigerian herb called Massularia Acuminate that’s traditionally been used as both a chewing stick and an aphrodisiac.

      As we see with most herbal test boosters, there’s not a ton of literature out there on human tests, they’re mostly done on animals. In those animal trials, Massularia Acuminate successfully increases sexuality and testosterone levels comparable to Viagra, but slightly less.[8]

      The corresponding human dose that would be needed is roughly 8mg/kg bodyweight or 700mg for a 200lb person.[9] Again, you’re not getting that amount here, but this is included as more of a support for your testosterone system instead of a full on boost for it.

      Years ago, this ingredient was first found in USPLabs’ Pink Magic, a now-discontinued supplement that had early rave reviews.

    • N-Methyl-D-Aspartic Acid 99% Purity

      D-Aspartic Acid Post Cycle Therapy

      These are the results of Testosterone increases from DAA. Many think that NMDA will elicit similar benefits, but the research doesn’t support that line of thinking.

      N-Methyl-D-Aspartic Acid (NMDA) is synthesized in the body from D-Aspartic Acid (DAA). It acts as a signaling compound in the testes and the brain that instructs cells to ramp up their activity.

      Manufacturers often include NMDA in test boosters to capitalize on the studies showcasing DAA as an effective means for increasing testosterone.[10] Yet, NMDA doesn’t have any studies on its own validating its claim as an effective test booster. In fact, some research has shown it does next to nothing in terms of improving lean mass, decreasing fat, augmenting testosterone or decreasing estrogen.[11]

      Most likely, this is some window dressing on the part of ALR to catch those who are caught in the big hype of DAA and NMDA.

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Dosage

Take one (1) tablet twice daily with meals. Do not exceed four (4) tablets daily.

Aromatase inhibitor and on cycle therapy required

One big thing we must continue to stress is that Metanabol should be taken with an Aromatase Inhibitor (AI) alongside it — Arimistane at the very least — due to the estrogenic effects of 4-andro.

Once again, only blood tests before, during, and after the use of this aggressive prohormone can key you into how strong of support you need.

Arimistane can be found in Olympus Labs Ar1macare Pro, which is the on cycle support supplement we recommend to assist with any of the other negative side effects from the prohormones. They can be stressful on the liver, kidneys, and cardiovascular system.

In addition, we believe that additional cardiovascular support could be helpful – a great low-cost supplement to add to the mix is Heart Science by Source Naturals – it has other great natural ingredients such as garlic, magnesium/potassium, arginine, and CoQ10.

Post cycle therapy required!

HumaPro Cocktail

Fuel your gains with an intraworkout cocktail of ALR’s HumaPro.

Beyond the on cycle therapy that’s used, once your cycle is over, it’s prudent to begin a true prescription-strength post cycle therapy run as well. Both 1-Andro and 4-Andro will lower natural testosterone production, and they must be brought back slowly.

This must be done under the tutelage of your endocrinologist alongside blood tests.

See our guide on post cycle therapy (PCT), but the “standard” recommendation is that a course of Nolvadex at 40mg for 2 weeks followed by another 2 weeks at 20mg is typical for prohormones. Again, your mileage may vary, so see your doctor and have blood tests ready to go!

Takeaway

For the foreseeable future, prohormones are the name of the game in terms of edgy supplements. Until the FDA decides to turn their critical eye this way, prohormones will continue to be available to those who are looking to push past their natty limits and really elevate their gains.

Metanabol uses four of the most well known prohormones around and should give you those big time gains you’re striving for. You get the 4-andro base as your testosterone base, and 1-andro for the proven games.

Just remember, as with all prohormones, consult with your doctor, get blood tests done, use both on cycle and post cycle therapy, and follow the proper dosing instructions at all times.

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Metanabol Label

The full Metanabol Label

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References

  1. Scott, T; Concise Encyclopedia Biology. Walter de Gruyter. p. 49. ISBN 978-3-11-010661-9; 1996
  2. Henderson, B; Hormones, Genes, and Cancer; Oxford University Press. p. 23. ISBN 978-0-19-513576-3; 2003
  3. Granados, J. et al; “Prohormone Supplement 3 -Hydroxy-5 -Androst-1-En-17-One Enhances Resistance Training Gains But Impairs User Health”; Journal of Applied Physiology; 116.5 (2013): 560-569; Retrieved from http://jap.physiology.org/content/jap/116/5/560.full.pdf (via  http://jap.physiology.org/content/116/5/560.long)
  4. http://digitalcommons.wku.edu/ijesab/vol2/iss1/13/
  5. http://www.ncbi.nlm.nih.gov/pubmed/21312304
  6. Sharma V, et al Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus pyrethrum DC . Phytother Res. (2012)
  7. Evaluation of the Anabolic, Aphrodisiac and Reproductive Activity of Anacyclus Pyrethrum DC in Male Rats
  8. Yakubu MT, et al; Pro-sexual effects of aqueous extracts of Massularia acuminata root in male Wistar rats . Andrologia. (2011)
  9. Guidance for Industry: Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers
  10. http://www.rbej.com/content/7/1/120
  11. http://www.ncbi.nlm.nih.gov/pubmed/24570624
  12. https://www.ncbi.nlm.nih.gov/pubmed/21116018
  13. http://digitalcommons.wku.edu/ijesab/vol2/iss1/13/
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