PEAK ATP – Extracellular Muscle Building!

In our never-ending quest to constantly add muscle or take workouts to the next level, we’re always looking for the next “it” ingredient that will help unlock some hidden potential we all posses. Sure you’ve tried creatine and beta alanine, but those workhorses are old news. Sure, they work, but what’s the Next Big Thing™?

Peak ATP

Peak ATP is a revolutionary new ingredient that increases extracellular levels of ATP allowing you to push harder and train longer.

Some interesting research has been published, giving rise a new potential powerhouse in the market with PEAK ATP®.

What is it and how does it work? Read on to see how this novel ingredient can be the next “big thing” in the war on weights!

What is PEAK ATP®?

PEAK ATP® is a patented form of ATP, chemically known as Adenosine 5’-Triphosphate Disodium. It was developed to improve athletic performance and overall body composition by increasing blood flow, muscular contractions and recovery.

The ingredient is licensed by TSI Inc (who did not pay for this post — we only reached for contact after publishing this initial article).

Getting Extracellular

Sometimes, we get so focused on something that we forget to investigate the whole picture. That’s been the case with ATP and supplementation, up until recently:

  • Intracellular ATP acts as the primary currency of cellular energy within cells. You may see this mentioned a lot in other supplement searches, such as when reading articles on creatine.
  • Extracellular ATP — which is outside of the cell — is rarely mentioned though, yet it’s just as important. Circulating levels of ATP in the blood play a role in governing muscle excitability and can contribute to growth within the muscles.

The rub is that you can’t just ingest ATP – the molecule itself is not bioavailable.

PEAK ATP® looks to change that.  It raises levels of extracellular ATP, which enhances power generation, strength, recovery and muscular growth — all attributes any athlete wanting to push themselves to new heights would be interested in.

But most importantly, PEAK ATP® is the only form of ingestible ATP delivery proven to aid athletic performance and overall body composition.

PEAK ATP® Benefits

PEAK ATP® will be used primarily in pre workout supplements which means its benefits will include:

MuscleTech Peak ATP

The gains are real, but there is one caveat to the Peak ATP research that MuscleTech sites here that we need to discuss.

  • Increased Strength[1]
  • Greater Endurance[1]
  • Enhanced Power Output[1]
  • Improved Body Composition and lean mass gains[1]
  • Reduces Fatigue[3]
  • Greater Vasodilation[2]

There are caveats to these benefits, though, so we’re going to present you with both sides. Let’s start with the nuts and bolts first, though.

How does PEAK ATP® Work?

For a long time, researchers and physiologists were only aware of the function of intracellular ATP. In the 1980s, it was discovered that extracellular ATP also plays a big role in muscular function and growth.

Purinergic receptors reside in the plasma membrane of the cell. ATP behaves as a signaling molecule on these purinergic receptors controlling vasodilation, muscular excitability, and anabolic (muscle-building) signaling. PEAK ATP® increases extracellular levels of ATP, which would lead to GREATER vasodilation, excitability and anabolic signaling!

PEAK ATP Purinergic Receptors

Image courtesy of

Muscular fatigue is caused by a decrease in the muscle’s ability to quickly respond to a stimulating mechanism which tells it to contract, a.k.a. muscular “excitability.” This stimulating mechanism is calcium.

However, intense physical activity depletes calcium reserves in a cell, which in turn causes a decrease in excitability and the onset of fatigue. Interesting enough, a 50% decrease in cellular calcium can result in an 80% drop in force generation![4] So, it makes sense that muscular fatigue can be combatted by increasing muscular excitability, which would result in greater muscular contractions.

This all sounds well and good, but is there any research to back up these claims?

The Research

So far, three big studies have been published on PEAK ATP® and its effects performance and body composition.

  • Study #1

    The first trial conducted in 2013 at the University of Tampa by Dr. Jacob Wilson was a double-blind, placebo-controlled study to determine the effects of PEAK ATP® on strength, power, lean body mass and indicators of muscular damage.[1]

    21 resistance trained men were divided into two groups. The experimental group received 400mg of PEAK ATP® each day for 12 weeks split. Power, strength, and muscle mass were measured at 4, 8, and 12 weeks.

    At the end of the trial, the test group experienced:

    • 147% strength increase over the placebo group
    • 30% power increase over the placebo group
    • 100% increase in lean body mass over placebo
    • 96% increase in muscle thickness of placebo group

    Insane gains, especially when you realize that the placebo group made great gains too — but more on that later.

  • Study #2

    The second study, also conducted in 2013 at the University of Tampa, was a 1-week trial. 20 individuals were split into two groups and randomly assigned to the ATP group and non-ATP group.

    A 400mg dose of PEAK ATP® was administered 30 minutes prior to session of arm exercises. Blood flow and vasodilation were measured at 0, 3, and 6 minutes after performing the exercises. The test group showed significant increases in overall blood flow and vasodilation in the brachial arteries as measured by ultrasound.[2]

  • Study #3

    Peak ATP Rathmacher Study

    Participants in the Rathmacher Study were able to exercise for a longer duration before succumbing to fatigue when using Peak ATP.

    The third and final study, conducted in 2012, was another double-blind, placebo-controlled, study assessed the ergogenic effects of 200 mg of PEAK ATP® administered twice daily for 15 days. 16 male and female subjects were randomly chosen to receive either PEAK ATP® or a placebo for 15 days. After an overnight fast, they were tested for strength and fatigue on three sets of 50 maximal knee extensions at baseline and at the end of the 15 days.[3]

    After a 1-week washout period, the groups were switched, so those that were receiving PEAK ATP® received a placebo instead, and vice versa.

    At the end of the 15 days, low peak muscle torque and fatigue was improved during the sets of maximal knee extensions. The researchers concluded that PEAK ATP® “reduced muscle fatigue and improved a participant’s ability to maintain a higher force output at the end of an exhaustive exercise bout.”[3]

The Caveat

If those studies above sound too good to be true, they “kind of” are. The first two studies were performed at the University of Tampa, and have what we call the “Jacob Wilson Effect”.

The Jacob Wilson Effect

The fact is that every physical performance study that Dr. Wilson touches turns to gold.

This man is a true mastermind of workout plans that get results, and it’s amplified by the world-class facility they have in Tampa. We pointed this out during our discussion on the Clear Muscle research, where even his placebo groups make crazy gains.

Put simply, train like a serious athlete, get serious results. That’s what happens with Jacob Wilson’s studies, so you definitely need to take them with a grain of salt.

Dr. Jacob Wilson - The man behind the research

Dr. Jacob Wilson – The man behind the research

All hope is lost? Not at all

Is Peak ATP for real? Yes – at least to a degree. But are you going to get 147% more strength gains than you otherwise would have – all while still working your same old lame workout? Probably not.

So, when you see the claims made – they are for real, but they were also made with real deal training.

It still worked in the one-week study

On the flip side, you can combat the caveat argument above by noting that there were still positive effects over placebo even in the one-week study. In that case, there’s not a ton of time for any of these magnificent training methods to take hold, so something is clearly going on here.

What kind of freak workout was this?

We don’t have the exact workouts that were done with the above Peak ATP studies, but you can get an idea of Wilson’s methods by seeing the workouts done with Clear Muscle.

We’re talking about high-weight squats, bench, and deadlift, 3x/week, all with spotters and trainers pushing both groups to their best. Lots of 5×5 for power, but also lots of volume for hypertrophy – hitting hypertrophy, power, and strength from all sides for eight weeks.

Then they pushed it even harder for two weeks by working out 5x/week, and finally tapering it down with more 5×5 work.[5]

Point being, if you want these types of results, you need to put serious work in… otherwise you may not get your money’s worth.


The recommended dose of PEAK ATP® is 400mg daily, ideally taken on an empty stomach. On training days, consume PEAK ATP® approximately 30-60 minutes prior to exercise. On non-training days, take one serving approximately 20-30 minutes prior to breakfast.

PEAK ATP® is available as a non-enteric-coated powder, packaged within two-piece hard shell capsules or as bulk powder delivery.

PEAK ATP® Products

MuscleTech Plasma Muscle

Plasma Muscle is hitting the market with the 400mg dose used in the trials.

PEAK ATP® is still pretty new on the supplement scene, so you may have a hard time finding it, but rest assured, we scoured the market and came up with a few options for you:

  • MuscleTech

    When it comes to having PEAK ATP® available in a number of products, MuscleTech delivers the goods with three different options to meet your ergogenic demands. They are:

    • Plasma Muscle

      MT’s now-released product that completes their “muscle-building supplement trilogy.” Each serving provides 400mg of PEAK ATP® and 750mg of an ingredient called optiNOs® which is intended to increase blood flow and vasodilation, but has been helping us more with joint pain reduction!

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    • MuscleTech Muscle Builder

      This simply-named supplement is basically what we can consider “poor man’s Plasma Muscle” – it is simply 400mg Peak ATP but no OptiNOs alongside it.

      It’s sold at WalMart, but we also find it on Amazon as well.

      If you want to try Peak ATP for the cheapest, as of time of press, this is your best shot.

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    • Peak SX-7

      A capsule form of PEAK ATP® that provides 400mg of the goods in a 2 capsule serving. This is part of a GNC-exclusive product line, but as we write this, has also made its way onto Amazon Prime (and at a cheaper price).

      Compare below:

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    • #Shatter SX-7

      A pre workout powder that provides 200mg of PEAK ATP® per serving, so you’ll need 2 scoops to get the clinically effective dose.

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    • #Shatter SX-7 Black Onyx

      A new GNC-exclusive product that we detailed yesterday (June 16, 2015), it is a variation of the above pre workout that too will have 200mg.

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  • EPIQ

    EPIQ 3X Lean Muscle

    If they’re making these claims, then we’re pretty sure the twice-daily dose is going to be enough.

    Another company supplied by Iovate (as in MT), EPIQ’s capsule based 3X Lean Muscle supplement packs an undetermined amount of PEAK ATP® in each 4 capsule serving.

    It’s included as part of a prop blend along with various other ergogenics including choline bitartrate, betaine, and grape seed extract. All ingredients that we love, but we’re not sure of the dose.

    Proprietary Blend? Might still be good to go…

    The one good piece of news here is that EPIQ is making the same marketing claims right there on the bottle (ie “muscle power & strength increases of 147%”), and in order to legally do that, they need to include the clinical doses.

    Iovate is too big and smart of a company to make illegal dosage-based claims, so we’re led to believe that if you take 2 caplets, twice per day, you’re going to get your 400mg. We’ll check with them to see if we can get confirmation on that, though.

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  • HIT Supplements

    HIT includes PEAK ATP® as part of its pre workout supplement, titled PEAK Perform. Available in stim and non-stim options, each scoop of PEAK Perform supples 200mg of PEAK ATP®.

    As with #Shatter SX-7, you’ll need 2 scoops to get proven clinical dosage, but only do that if you can handle the full stimulant load (follow the label instructions and always start light – the stimulants, not the ATP, should determine your dosing).

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  • Promera Sports

    PEAK 400 from Promera is our 2nd powder based delivery from of PEAK ATP®. Each scoop contains the proven effective dosage of 400mg.

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  • MyoPharma

    MyoPeak is another pre workout powder — each scoop contains 125mg caffeine alongside 200mg ATP — so at two scoops, you’ll have three solid weeks worth of clinical doses.

    Two other ergogenics are included in a double-scooper are 2.4g of beta alanine and 1g of BetaPower, a.k.a. betaine anhydrous to further your power and endurance desires.

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So check these out and make sure to sign up for alerts above to get the best available deal!

Wrap Up

Well, there you have it! PEAK ATP® shows some incredible promise as a key ingredient in helping you push your body and workouts to the next level… but you do have to work for it. Keep an eye out for this potent ergogenic ingredient as more and more people are made aware of it benefits!

Thank you for your interest. Please leave any comments or questions below, and join us on Facebook and Twitter for more updates on this ground-breaking compound

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  1. Wilson JM, et al. Effects of oral adenosine-5’-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men. Nutrition and Metabolism. 2013, 10:57.
  2. Lowery RP, et al. Oral ATP administration improves blood flow responses to exercise in both animal and human training models. Presented at 10th Annual ISSN Conference. Colorado Springs, CO. June 2013.
  3. Rathmacher JA, et al. Adenosine-5’-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets. Journal of the International Society of Sports Nutrition. 2012, 9:48.
  4. Zhang SJ et al. Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle. J Psysiol. 2006;572(2):551-9
  5. MuscleTech; The Clear Muscle 12-Week Training Schedule; Retrieved from
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