Peak ATP + Creatine: A Powerful ATP-Boosting Stack

There’s probably no supplement more researched than creatine.[1] Almost anyone who’s touched a barbell has taken creatine at some point. Its ability to improve performance and support muscle building is legendary.

Creatine takes time… but we also want effects now

The only problem with creatine is the necessity of the loading phase, a period lasting several weeks in which the creatine you take is building up to an effective concentration in your muscles. This long wait can be a little frustrating for some people, especially when you want to see those precious gains now.

Peak ATP and Creatine

So, attempts have been made over the years to develop a better, faster-acting creatine. Unfortunately, none of those have worked. Plain old creatine monohydrate is still just as effective as any fancier creatine on the market.[2]

Ideally, we could stack something with creatine that would give us the same ergogenic benefits of creatine, but more immediately. Since creatine’s basic mechanism of action is helping your body replenish intramuscular ATP stores, we want something that also affects ATP in a complementary fashion.

What better supplement for this purpose than ATP itself? We’re talking about Peak ATP, the patented exogenous ATP supplement from TSI Group Ltd.[3-5] The combination of creatine and Peak ATP has demonstrated itself to be quite powerful – consumers seemingly can’t get enough of formulas based on this hard-hitting combination.

One great example of such a product is Structure by Undefined Nutrition, Brian Shaw’s ATP-boosting muscle builder. Consumer feedback on this product has been overwhelmingly positive, so let’s take a minute to talk about why this formula is so effective, and why some of the best-selling muscle-building supplements have both creatine and Peak ATP.

Peak ATP Ultrasonography Graph

Ultrasonography-determined mean volumetric blood flow in the brachial artery in 12 college-aged resistance-trained subjects with Peak ATP® and control (CON). [6]

Creatine + Peak ATP – Complementary Synergistic Effects

While creatine and Peak ATP both have ATP-mediated ergogenic effects,[1,7] their physiological roles are different and complementary.

Creatine helps keep ATP stores topped off inside your muscles. Creatine supplements have been shown to increase muscle creatine and phosphocreatine stores by 10-40%, which helps catalyze the conversion of adenosine diphosphate (ADP) to adenosine triphosphate (ATP). This, in turn, helps your muscles function closer to peak capacity.[1]

ATP Release Diagram

ATP released from erythrocytes binds to purinergic receptors, which initiate a vasodilatory cascade through nitric oxide synthesis.[8]

Peak ATP, on the other hand, works primarily in the cardiovascular system,[7] where it triggers vasodilation and helps improve the delivery of raw nutrients and energy substrates to your muscles. Thanks to this improved blood flow, Peak ATP supplementation can help muscles work harder, and recover better,[6] leading to bigger gains in muscle mass.[7]

In other words, creatine and Peak ATP both help keep your muscles fueled, in different ways. Creatine helps your muscles maintain the reserve of cellular energy they need to metabolize oxygen, glucose, ketones, and other nutrients that Peak ATP helps deliver more effectively.

As it turns out, ATP is a crucial signaling molecule in all vasodilation – shear stress from increased blood pressure and heart rate causes endothelial cells to release ATP, which triggers nitric oxide synthesis.[8] When placebo-controlled Peak ATP studies directly measure arterial blood flow, they consistently find more blood volume in the Peak ATP group.[6]

A snapshot of the Peak ATP research

The best summation of Peak ATP’s clinically-backed research is in a review article written by Dr. Ralf Jaeger:[7]

The available literature on ATP disodium when provided in a dose of at least 400 mg approximately 30 min before a workout or 20–30 min before breakfast on non-exercise days provides insight into its potential to reduce fatigue (Purpura et al., 2017,[9] Rathmacher et al., 2012[10]), increase strength and power (Wilson et al., 2013[11]), improve body composition (Hirsch et al., 2017[12], Wilson et al., 2013[11]), maintain muscle health during stress (Long and Zhang, 2014,[13] Wilson et al., 2013[11]), increase recovery and reduce pain (de Freitas et al., 2018[14], Khakh and Burnstock, 2009,[8] Wilson et al., 2013[11]). Additionally, other literature indicates a role for ATP in improving cardiovascular health (Hirsch et al., 2017,[12] Ju et al., 2016,[15] Rossignol et al., 2005[16]).[7]

You can learn more about Peak ATP in our article titled PEAK ATP: The Ultimate Guide to Disodium ATP Supplements as well as a podcast with Dr. Ralf Jaeger (Episode #078), but let’s keep moving into the performance-related benefits of these two:

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Ergogenic Effects of Creatine and Peak ATP: Side by Side

With all of that in mind, let’s briefly summarize what the research has to say about these two compounds’ ergogenic effects.

  • Creatine:

    Creatine Mitochondria ADP ATP

    A study published in 2011 does a fantastic job showing creatine’s role in the production of ATP in the mitochondria.[17]

    Mentioned in the podcast linked above with Dr. Jaeger, creatine often follows a “5-15” rule, where many performance metrics improve by 5-15%.[1] For instance, creatine administration in combination with resistance exercise helps:

    • Increase maximal power and strength by 5-15%[1]
    • Increase work performed during sets of maximal effort muscle contractions by 5-15%[1]
    • Increase work performed during repetitive sprint performance by 5-15%[11]
    • Increase single-effort sprint performance by 1-5%[1]

    Long-term creatine supplementation appears to enhance the overall quality of training, leading to 5-15% greater gains in strength and performance.[1] Approximately 30% of subjects are non-responders to creatine supplementation and creatine has been shown to increase body mass by about 1-2 kilograms in the first week of loading which limits its use in athletes with weight restrictions.[1]

  • Peak ATP

    Peak ATP

    Peak ATP is a patented oral ATP supplement that’s been shown to increase blood flow, boost muscle activation through calcium release, and help boost muscle mass, strength, and recovery. This article covers the biochemistry, mechanism, and human research in detail.

    Meanwhile, regular consumption of Peak ATP (400 milligrams per day) has been shown to improve:

    • Blood flow[6]
    • Total strength by 147% more than training alone[11]
    • Vertical jump power by 30% more than training alone[11]
    • Lean body mass by 100% more than training alone[11]
    • Muscle thickness by 96% more than training alone[11]
    • Muscular fatigue[10]
    • Muscular contractility[18]
    • Peak power[18]
    • Post-exercise ATP levels[18]
    • Recovery and reduce pain[13,14]

A Combination That’s Faster-Acting

Unlike creatine, Peak ATP works immediately after you take it. By stacking Peak ATP with creatine, you’re getting many of the intended ergogenic effects while you wait for your muscles’ creatine stores to reach saturation. And once the creatine does start working, the complementary mechanisms of action mean you’ll still be getting additive benefits from taking both compounds.

Creatine ATP Shuttle

The Creatine ATP Shuttle

Creatine supplementation is important because creatine is biologically / metabolically ‘expensive’ to produce in the body.[19] So theoretically, if we can:

  1. Provide the body with more creatine, it doesn’t need to generate it endogenously, saving energy and freeing up the metabolism to do other important tasks.
  2. Provide the body with more ATP, then it doesn’t need to pull as much from creatine stores to produce its own ATP either.

Together, these fill the creatine pool and keep it filled longer, leading to numerous synergistic benefits.

How to take creatine

Typically, the loading phase entails taking 3-5 grams of creatine daily for 28 days.[1] One less-discussed alternative to this basic strategy is to take 0.3 grams of creatine per kilogram of body weight per day for 5 to 7 days (e.g., 5 grams, 4 times per day), and then use a maintenance dose of 3-5 grams once per day.[1]

How to take Peak ATP

Dr. Ralf Jaeger ATP PricePlow Podcast

In Episode #078 of the PricePlow Podcast, Dr. Ralf Jaeger dove into ATP, explaining how supplementing Peak ATP improves workout performance.

The clinically validated dose of Peak ATP is 400 milligrams per day. TSI Group, the sponsors of this artucle, suggest that you take this dose 30-60 minutes before a workout, or 20-30 minutes before breakfast on non-training days. Always take ATP on an empty stomach, with a glass of water.

Products that have both Peak ATP and Creatine Inside

Looking for a great way to get started? Check out these products and stacks:

  1. We Go Home Guerilla Strength – Military-grade pre-workout supplement from legendary veteran Trung Nguyen
  2. Undefined Structure, Brian Shaw’s muscle-buildings supplement, as introduced in this article.
  3. MuscleTech Muscle Builder (Peak ATP) and MuscleTech Platinum 100% Creatine – For a build-your-own capsule stack.

Conclusion: A synergistic combo that makes too much sense to miss

The Creatine and Peak ATP stack is simple, but amazingly effective thanks to the complementary synergistic effects between these two compounds and Peak ATP’s ability to immediately improve blood flow and performance.

As always, you can go back to our main Peak ATP article and listen to PricePlow Podcast Episode #078 with Dr. Ralf Jaeger, where we talk all things ATP.

Peak ATP – Deals and Price Drop Alerts

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Undefined Structure ATP Muscle Builder

Take your gains to the next level with Brian Shaw’s ATP-boosting muscle building supplement, Undefined Nutrition’s Structure.

About the Author: PricePlow Staff

PricePlow Staff

PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

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  1. Kreider, Richard B et al. “International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine.” Journal of the International Society of Sports Nutrition vol. 14 18. 13 Jun. 2017, doi:10.1186/s12970-017-0173-z
  2. Kreider, Richard B et al. “Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review.” Nutrients vol. 14,5 1035. 28 Feb. 2022, doi:10.3390/nu14051035
  3. Lee, Steve S, et al; “Method for increasing muscle mass and strength through administration of adenosine triphosphate”. United States Patent and Trademark Office; Patent #US7629329B2. 08 Dec 2009;
  4. Rathmacher, John, et al; “Compositions containing adenosine triphosphate (atp) and methods of use for cognitive function”. International Patent #WO2022271813A1. 29 Dec 2022;
  5. Rathmacher, John, et al; “Compositions containing adenosine triphosphate (ATP) and methods of use”. United States Patent and Trademark Office; Patent #US11666593B2. 06 Jun. 2023;
  6. Jäger, Ralf et al. “Oral adenosine-5′-triphosphate (ATP) administration increases blood flow following exercise in animals and humans.” Journal of the International Society of Sports Nutrition vol. 11 28. 13 Jun. 2014, doi:10.1186/1550-2783-11-28
  7. Jäger, Ralf, et al. “Health and Ergogenic Potential of Oral Adenosine-5′-Triphosphate (ATP) Supplementation.” Journal of Functional Foods, vol. 78, Mar. 2021, p. 104357, doi:10.1016/j.jff.2021.104357;
  8. Khakh, Baljit S, and Geoffrey Burnstock. “The double life of ATP.” Scientific American vol. 301,6 (2009): 84-90, 92. doi:10.1038/scientificamerican1209-84
  9. Purpura, Martin, et al. “Oral Adenosine-5′-Triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout.” Journal of the American College of Nutrition, vol. 36, no. 3, 1 Mar. 2017, pp. 177–183, 10.1080/07315724.2016.1246989;
  10. Rathmacher, John A et al. “Adenosine-5′-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets.” Journal of the International Society of Sports Nutrition vol. 9,1 48. 9 Oct. 2012, doi:10.1186/1550-2783-9-48;
  11. Wilson, Jacob M et al. “Effects of oral adenosine-5′-triphosphate supplementation on athletic performance, skeletal muscle hypertrophy and recovery in resistance-trained men.” Nutrition & metabolism vol. 10,1 57. 22 Sep. 2013, doi:10.1186/1743-7075-10-57
  12. S.P. Hirsch, L.G. Huber, R.A. Stein, K. Schmid, A.G. Swick, S.V. Joyal; “A randomized, double-blind, placebo-controlled study comparing the healthy levels of blood sugar and endothelial function of PEAK ATP® with GlycoCarn®, PEAK ATP® and GlycoCarn® supplementation versus placebo (Abstract)”; FASEB Journal, 31 (1) (2017), p. 973.978; doi:10.1096/fasebj.31.1_supplement.973.8;
  13. Long, Gong, and Guo Qiang Zhang. “Effects of adenosine triphosphate (ATP) on early recovery after total knee arthroplasty (TKA): a randomized, double-blind, controlled study.” The Journal of arthroplasty vol. 29,12 (2014): 2347-51. doi:10.1016/j.arth.2014.03.025
  14. Freitas, Marcelo C et al. “A Single Dose of Oral ATP Supplementation Improves Performance and Physiological Response During Lower Body Resistance Exercise in Recreational Resistance-Trained Males.” Journal of strength and conditioning research vol. 33,12 (2019): 3345-3352. doi:10.1519/JSC.0000000000002198
  15. Ju, Jun, et al. “Treatment with Oral ATP Decreases Alternating Hemiplegia of Childhood with de Novo ATP1A3 Mutation.” Orphanet Journal of Rare Diseases, vol. 11, no. 1, 4 May 2016, 10.1186/s13023-016-0438-7;
  16. Rossignol, M., et al. “Measuring the Contribution of Pharmacological Treatment to Advice to Stay Active in Patients with Subacute Low-Back Pain: A Randomised Controlled Trial.” Pharmacoepidemiology and Drug Safety, vol. 14, no. 12, 2005, pp. 861–867, 10.1002/pds.1114;
  17. Wallimann, Theo, et al. “The Creatine Kinase System and Pleiotropic Effects of Creatine.” Amino Acids, vol. 40, no. 5, 1 May 2011, pp. 1271–1296, doi:10.1007/s00726-011-0877-3;
  18. Purpura, Martin et al. “Oral Adenosine-5′-triphosphate (ATP) Administration Increases Postexercise ATP Levels, Muscle Excitability, and Athletic Performance Following a Repeated Sprint Bout.” Journal of the American College of Nutrition vol. 36,3 (2017): 177-183. doi:10.1080/07315724.2016.1246989
  19. Brosnan, John T et al. “The metabolic burden of creatine synthesis.” Amino acids vol. 40,5 (2011): 1325-31. doi:10.1007/s00726-011-0853-y

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