Ditch the Scoop: VADE Extreme Pre Workout Packs Dissolve in Your Shaker

One thing we don’t see very often in the supplement industry is innovation in the product’s form factor and method of delivery. Although there are plenty of rising companies that are coming up with novel ingredients and exciting new formulas, pretty much everybody sticks to the tried-and-true delivery system: powders with scoops, or capsules/tablets/softgels.

VADE Nutrition Dissolvable Extreme Pre Workout

Now here’s a new way to take your pre-workout: in dissolvable packs! Meet VADE Nutrition and their Extreme pre-workout, which includes a full dose of Nitrosigine for pumps!

That boring streak is officially broken with VADE, whose 2018 appearance on Shark Tank propelled them into the public eye with a new technology to deliver ingredients into your shaker cup: readily-dissolvable packs that are designed to dissolve once mixed into water.

To use them, just drop the dose into your water bottle and shake for 10 to 20 seconds. After that, your shake is ready to go! It all started with protein packs, which is what VADE presented on Shark Tank. But now, they’re using the technology to take your pre-workout to the next level:

VADE Extreme Pre-Workout Packs: Drop In and Shake!

The young company has two pre-workouts – VADE Dissolvable Pre-Workout Packs and Vade Dissolvable Extreme Pre-Workout Packs. Today, we’re of course covering the extreme version, and the delivery design isn’t all that VADE has going for it: there are some excellent ingredient choices (such as a full dose of Nutrition21’s Nitrosigine) and flavors as well.

It’s covered below, but first, take a look at PricePlow’s prices and sign up for more VADE alerts if you want to see when the next “pod” drops:

VADE Nutrition Dissolvable Pre-Workout Packs Extreme – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

As for the ingredients, let’s take a look:


In a two-pack serving of VADE Extreme Pre-Workout, you get:

  • CarnoSyn Beta-Alanine – 3200 mg

    VADE Nutrition Dissolvable Pre-Workout Ingredients

    Plop two of these into your shaker cup, shake, and you’ll get all of these ingredients, with pumps powered by Nitrosigine

    Main purpose: boosting endurance

    Beta-alanine, when combined with the essential amino acid histidine, increases the body’s production of carnosine.[1] Carnosine “buffers” lactic acid in the muscle tissue, thereby prolonging muscular endurance.

    This effect is well-attested in the research literature, including two big meta-analyses— one from 2012 and another from 2016, with 360[2] and 1461 participants respectively,[3]. Both studies confirmed that for any form of exercise whose duration is between 30 seconds and 10 minutes, beta-alanine can boost endurance.[3]

    Beta-alanine also synergizes with mainstay pre-workout ingredient creatine,[4] which is also present in VADE Extreme Pre-Workout.

    A word about the beta-alanine “tingles”

    Although the tingling sensation that’s caused after ingesting beta-alanine can be alarming if you’re not expecting it, there’s nothing to worry about. According to a 2019 safety study, scientists concluded that beta-alanine “does not adversely affect those consuming it.”[5]

  • Creatine Monohydrate – 2500 mg

    Main Purpose: ergogenic aid, muscle synthesis

    Creatine is as proven as supplements can come. It’s an organic compound that helps your body create more adenosine triphosphate (ATP),[6-10] which has tons of awesome benefits, including:

    VADE Nutrition Dissolvable Pre Workout Packs

    Pre-workouts have never been more interesting

    • Higher power output[11,12]
    • Weight gain[13]
    • Lean mass gains[12,14-17]
    • Faster sprint speed[18-20]
    • Better hydration[21]
    • Lower fatigue[13,22-24]
    • Higher sense of well-being[25-27]
    • Better cognition (in vegans and vegetarians)[28,29]
    • Slightly higher levels of testosterone[6,30-33]
    • Increased bone mineral density[16]

    These down-stream effects have been observed in dozens — if not hundreds — of research studies, as well as and meta-analyses.

    We could go on about creatine, but suffice it to say there’s simply too much data to ignore the ingredient. The million-dollar question is: how much creatine do you need? The answer depends partly on your way of eating. Carnivores and omnivores can get creatine from meat. But even then, some supplementation is probably necessary to reach the standard total amount of 3 to 5 grams per day.

    Point being: this is a dose high enough to replace excreted creatine, but you may need a bit more if you’re not eating meat. Rather than tell you to go buy more creatine to get another 500 milligrams in, we’d rather you just eat some steak!

  • Betaine Anhydrous – 1500 mg

    Main Purpose: Ergogenic muscle builder.

    VADE Nutrition Dissolvable Extreme Pre Workout Packs

    The Extreme version is packaged in the green and black bag

    Betaine, also known as trimethylglycine (TMG), has some effects that are similar to creatine’s. Whereas creatine acts as a phosphate donor, betaine is a methyl donor, and, as a result, can reduce homocysteine levels,[34] which is important for peak cardiovascular health.

    Like creatine, betaine is an osmolyte. It helps to draw water and nutrients into the body’s cells, thereby strengthening[35,36] protecting them from heat shock.[37]

    After many years of research showing betaine’s awesome performance benefits,[38-43] two groundbreaking studies came out in 2013 and 2014. They demonstrated that 2.5 grams of betaine, taking daily, produced 5.3 pounds of lean mass gain and 6.4 pounds of fat loss, which translated to an amazing 3% body fat reduction in just six weeks.[36,44]

  • Nitrosigine (Inositol-stabilized arginine silicate) – 1500 mg

    Main purpose: increase nitric oxide production for pumps

    Nutrition21 Nitrosigine Runner

    Perform at your peak with 1.5 grams of Nitrosigine!

    If you want an awesome blood-enriched muscle pump, you need lots of nitric oxide. Starting in the “golden age of bodybuilding,” people tried to maximize nitric oxide production by supplementing with arginine. Unfortunately, as time went on, this proved ineffective. The problem is that when arginine is taken orally, it breaks down in the gut by the “first pass” effect. The upshot is that most of the arginine you take doesn’t get absorbed into the bloodstream. In other words, oral arginine is not very bioavailable.[45]

    Nutrition 21 solved this problem by synthesizing a stable form of arginine, called Nitrosigine.

    Nitrosigine is a combination of arginine, inositol, and potassium silicate.[46] When arginine is buffered by these other two molecules in the gut, it becomes significantly more bioavailable than ordinary arginine.[47] This is probably because nitrosigine inhibits arginase, the enzyme that breaks down arginine in the gut.[48]

    The Nitrosigine form of arginine is both fast acting and long lasting: it becomes biologically active as quickly as 30 minutes after ingestion, and lasts somewhere between 90 minutes and six hours.[49,50]

    Cognitive performance gains with Nitrosigine too

    Nitrosigine Benefits

    Nitrosigine is research-backed and “gym backed” — Image courtesy Nutrition21

    Amazingly, the benefits of Nitrosigine go beyond physical performance: it has been shown, in a research setting, to improve multiple domains of cognition in athletes[51] by preventing the temporary cognitive decline that usually follows intense exercise. Athletes who received Nitrosigine completed cognitive tests faster compared to placebo.[51]

    Beyond preventing cognitive decline, a new paper just recently published titled Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults showed that Nitrosigine also increases memory and RBANS (Repeatable Battery for the Assessment of Neuropsychological Status) when compared to placebo — and it was performed on healthy adults![52]

    There’s just something great about getting extra blood flow, and it’s not just to the muscles with Nitrosigine.

  • L-Tyrosine – 500 mg

    Main purpose: energy and alertness

    L-tyrosine is the precursor to norepinephrine and dopamine, neurotransmitters that help increase alertness.[53] When we take L-Tyrosine, it activates the sympathetic nervous system by upregulating these neurotransmitters, pushing us into “fight or flight” mode.

    One interesting thing about L-tyrosine is that it supports cognition in people who have been acutely deprived of sleep.[54,55] So if you have to skip some sleep in order to make time for your workouts, L-tyrosine can definitely help.

  • Taurine – 2000 mg

    Main Purpose: Hydration-driven endurance

    Like creatine and betaine, taurine is also an osmolyte, helping to improve endurance while reducing oxidative stress, facilitating muscle contractions by improving calcium signaling, and aiding with fat digestion.[56-59]

    Taurine Benefits

    Taurine’s Benefits (endurance-wise) can be seen after a single use![58]

    A 2018 meta-analysis showed that taurine is incredibly fast acting: a 1 to 6 gram dose boosted endurance even after taken used just once.[58]

    There are also some cognitive benefits[57] and increased nitric oxide production[59] to be gained from taurine. We’re seeing more and more pre-workout formulas using taurine, and it’s no wonder why.

    This is an incredible dose – we’re often happy with half of this, but two grams will certainly yield improvements and help increase mitochondrial health while we’re at it.[60]

  • N-Acetyl-Carnitine – 500 mg

    Main purpose: energy production, performance, recovery

    L-carnitine, a conditionally-essential amino acid that’s synthesized by the body in limited quantities, is central to energy production. It helps the body oxidize fat by transporting fatty acids into the mitochondria, which use the fatty acids to create ATP.[61] Because the body can only produce so much carnitine, diet and supplements are required for us to get the optimal daily serving.

    A meta-analysis published in 2016 reviewed nine randomized, double-blind, placebo-controlled studies and found that dieters who supplemented with L-carnitine lost significantly more weight and achieved lower body mass index (BMI) than controls.[62]


    After reading a new review based upon 100 citations, we are finding fewer and fewer reasons not to take ~2g L-Carnitine each day

    Another study, this one from 2009, found that subjects who took 2 grams of carnitine daily for 24 weeks exhibited better insulin sensitivity and blood sugar responses.[63] That’s important for metabolic flexibility because the body stops burning fat if insulin or glucose levels are too high.[64,65]

    L-carnitine for performance

    A 2018 research review found that supplementing with carnitine reduces muscle soreness while improving power, circulation, aerobic capacity, and recovery.[66]

    Carnitine is important if you’re training hard

    Over time, researchers have learned that carnitine supplementation works best for those who have a special need for it. For example, non-meat-eaters,[67-70] seniors,[71,72] and overtrained athletes.[66]

    Long story short, if you’re training hard, you’ll blow through your amino acid stores faster than usual, and carnitine supplementation is probably a good idea.

  • Adenosine 5′-Triphosphate Disodium (PEAK ATP) – 400 mg

    PEAK ATP is a patented form of extracellular adenosine triphosphate (ATP) created by TSI, Inc. It’s one of the few exogenous ATP supplements that has ever been shown to work.

    When PEAK ATP is ingested, extracellular ATP levels in the body rise, thus raising muscle excitability and increasing vasodilation and anabolic signaling.[73]

    A 2013 research study found that subjects who got 400 milligrams of PEAK ATP daily experienced increased strength and lean mass by a whopping 147% and 100% respectively, compared to the placebo group.[73]

    But if that’s not enough for you, consider this: PEAK ATP supplementation really does reduce fatigue,[74] which is exactly what you’d expect from an ATP supplement.

  • Caffeine – 260 mg

    The first thing to note about this dose of caffeine, the ubiquitous wakefulness-promoting and performance enhancing drug that’s used daily by the vast majority of American adults, is that 260 milligrams is a lot for beginners. It’s the amount you’d expect to find in 2 or 3 cups of coffee. But remember, this is the “Extreme” Pre-Workout from VADE – they have another version if you’re feeling less extreme.

    VADE Pre Workout

    Vibes are high for the VADE Pre Workout

    The one issue with this delivery system is that you’re either going to mix up 130 milligrams (in one pod pack) or 260 milligrams (in two) – there’s no easy titrating of the powder or doing “heaping scoops” – so mix what you mix, and drink what you feel like drinking. For us, we’re taking two packs and drinking it all!

    The primary mechanisms of action for caffeine are inhibiting adenosine and phosphodiesterase,[75] which will help you stay awake and alert – or get going in the morning, as most of us know! Caffeine can also raise the metabolic rate and promote metabolic flexibility by liberating fatty acids from your body’s stores of fat, so that they can be used for energy.[76-78]

    Caffeine anhydrous is the “fast-acting” form of caffeine, and is usually found in pre-workout formulas for that reason.

    Green Tea Extract is a source of caffeine

    Much like creatine, green tea extract is one of those supplement ingredients that’s backed by so much research you couldn’t possibly discuss all of it. With VADE Extreme Pre-Workout Packs, it’s added as a source of caffeine. The benefits of green tea extract include:

    VADE Nutrition Pre Workout Pack

    If this is too much caffeine, the non-extreme version will bring less.. but it doesn’t have Nitrosigine

    • Higher fat oxidation and lower body fat percentage[79]
    • Improved circulation[80]
    • Increased insulin sensitivity[81,82]
    • Decreased blood pressure[83]
    • Higher sense of general well-being[83]

    It’s possible that green tea can also inhibit the glucuronidation of testosterone, which effectively increases the half-life of testosterone and duration of its action in the body.[84] In animal models, there is limited evidence that green tea extract could inhibit aromatase, the enzyme that converts testosterone to estrogen.[85]

    And of course, green tea extract is a source of caffeine, whose benefits we discussed above.

Flavors available

    Watch VADE Nutrition’s Shark Tank Pitch

    Subscribe to PricePlow on YouTube!

    Conclusion: Pre-Workout Packs/Pods are here!

    VADE Extreme Pre-Workout Packs Label

    The full back label

    For something like a gummy gel pack form factor (quite possibly inspired by Tide Pods), you’d probably expect the product to rely on this as a gimmick, but that is absolutely not true in the case of VADE Extreme Pre-Workout. Given how much research has been published on Nitrosigine — and a new study just published a month before this article — a full 1500 milligram dose brings everything into legitimacy.

    But beyond Nitrosigine, we also have some truly sophisticated ingredient choices, including a couple awesome ones we rarely see, such as PEAK ATP.

    If you’re looking for something new, entertaining and awesome, with delicious flavors, definitely give VADE Extreme Pre-Workout a try.

    VADE Nutrition Dissolvable Pre-Workout Packs Extreme – Deals and Price Drop Alerts

    Get Price Alerts

    No spam, no scams.

    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

    No Comments | Posted in | Tagged , , , , , , , , , , , , , , , , , , , , .


    1. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    2. Hobson, R M et al. “Effects of β-alanine supplementation on exercise performance: a meta-analysis.” Amino acids vol. 43,1 (2012): 25-37. doi:10.1007/s00726-011-1200-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
    3. Saunders, Bryan, et al. “β-Alanine Supplementation to Improve Exercise Capacity and Performance: A Systematic Review and Meta-Analysis.” British Journal of Sports Medicine, vol. 51, no. 8, 18 Oct. 2016, pp. 658–669; https://bjsm.bmj.com/content/51/8/658.long
    4. Rawson ES, Volek JS. Effects of creatine supplementation and resistance training on muscle strength and weightlifting performance. J Strength Cond Res. 2003 Nov;17(4):822-31; https://pubmed.ncbi.nlm.nih.gov/14636102/
    5. Dolan, Eimear, et al. “A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.” Advances in Nutrition, vol. 10, no. 3, 13 Apr. 2019, pp. 452–463, 10.1093/advances/nmy115; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520041/
    6. Sheikholeslami Vatani, D., et al. “The Effects of Creatine Supplementation on Performance and Hormonal Response in Amateur Swimmers.” Science & Sports, vol. 26, no. 5, Nov. 2011, pp. 272–277, 10.1016/j.scispo.2011.07.003; https://www.sciencedirect.com/science/article/abs/pii/S0765159711001171
    7. Mujika, I., and S. Padilla. “Creatine Supplementation as an Ergogenic Aid for Sports Performance in Highly Trained Athletes: A Critical Review.” International Journal of Sports Medicine, vol. 18, no. 07, Oct. 1997, pp. 491–496, 10.1055/s-2007-972670; https://www.ncbi.nlm.nih.gov/pubmed/9414070
    8. Terjung, RL, et al; “Physiological and Health Effects of Oral Creatine Supplementation.” Medicine & Science in Sports & Exercise, vol. 32, no. 3, Mar. 2000, pp. 706–717, 10.1097/00005768-200003000-00024; https://www.ncbi.nlm.nih.gov/pubmed/10731017
    9. Guzun, R., et al. “Systems Bioenergetics of Creatine Kinase Networks: Physiological Roles of Creatine and Phosphocreatine in Regulation of Cardiac Cell Function.” Amino Acids, vol. 40, no. 5, 10 Mar. 2011, pp. 1333–1348, 10.1007/s00726-011-0854-x; https://www.ncbi.nlm.nih.gov/pubmed/21390528
    10. Adhihetty, Peter J., and M. Flint Beal. “Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases.” NeuroMolecular Medicine, vol. 10, no. 4, 13 Nov. 2008, pp. 275–290, 10.1007/s12017-008-8053-y; https://www.ncbi.nlm.nih.gov/pubmed/19005780
    11. Stout JR, et al; “Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold”; J Strength & Cond Research; 2006 20(4): 928−931; https://www.ncbi.nlm.nih.gov/pubmed/17194255
    12. Branch, J David. “Effect of Creatine Supplementation on Body Composition and Performance: A Meta-Analysis.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 13, no. 2, 2003, pp. 198–226, 10.1123/ijsnem.13.2.198; https://pubmed.ncbi.nlm.nih.gov/12945830/
    13. Anomasiri, Wilai, et al. “Low Dose Creatine Supplementation Enhances Sprint Phase of 400 Meters Swimming Performance.” Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 87 Suppl 2, 1 Sept. 2004, pp. S228-232; https://pubmed.ncbi.nlm.nih.gov/16083193/
    14. Chilibeck, Philip, et al. “Effect of Creatine Supplementation during Resistance Training on Lean Tissue Mass and Muscular Strength in Older Adults: A Meta-Analysis.” Open Access Journal of Sports Medicine, vol. Volume 8, Nov. 2017, pp. 213–226, 10.2147/oajsm.s123529; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679696/
    15. Devries, Michael A, and Stuart M. Philips; “Creatine Supplementation during Resistance Training in Older Adults—a Meta-Analysis.” Medicine & Science in Sports & Exercise, vol. 46, no. 6, June 2014, pp. 1194–1203, 10.1249/mss.0000000000000220; https://pubmed.ncbi.nlm.nih.gov/24576864/
    16. Chilibeck, P. D., et al. “Creatine Monohydrate and Resistance Training Increase Bone Mineral Content and Density in Older Men.” The Journal of Nutrition, Health & Aging, vol. 9, no. 5, 2005, pp. 352–353; https://pubmed.ncbi.nlm.nih.gov/16222402/
    17. Candow, Darren G., et al. “Creatine Supplementation and Aging Musculoskeletal Health.” Endocrine, vol. 45, no. 3, 5 Nov. 2013, pp. 354–361, 10.1007/s12020-013-0070-4; https://pubmed.ncbi.nlm.nih.gov/24190049/
    18. Bogdanis, G C, et al. “Recovery of Power Output and Muscle Metabolites Following 30 S of Maximal Sprint Cycling in Man.” The Journal of Physiology, vol. 482, no. 2, 15 Jan. 1995, pp. 467–480, 10.1113/jphysiol.1995.sp020533; https://www.ncbi.nlm.nih.gov/pubmed/7714837
    19. Mendez-Villanueva, Alberto, et al. “The Recovery of Repeated-Sprint Exercise Is Associated with PCr Resynthesis, While Muscle PH and EMG Amplitude Remain Depressed.” PLoS ONE, vol. 7, no. 12, 17 Dec. 2012, p. e51977, 10.1371/journal.pone.0051977; https://www.ncbi.nlm.nih.gov/pubmed/23284836
    20. Mielgo-Ayuso, Juan, et al. “Effects of Creatine Supplementation on Athletic Performance in Soccer Players: A Systematic Review and Meta-Analysis.” Nutrients, vol. 11, no. 4, 31 Mar. 2019, p. 757, 10.3390/nu11040757; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520963/
    21. Lopez, Rebecca M et al. “Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses.” Journal of athletic training vol. 44,2 (2009): 215-23. doi:10.4085/1062-6050-44.2.215; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2657025/
    22. Sakellaris, George, et al. “Prevention of Traumatic Headache, Dizziness and Fatigue with Creatine Administration. A Pilot Study.” Acta Paediatrica, vol. 97, no. 1, 3 Dec. 2007, pp. 31–34, 10.1111/j.1651-2227.2007.00529.x; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583396/
    23. Schneider-Gold, C., et al. “Creatine Monohydrate in DM2/PROMM: A Double-Blind Placebo-Controlled Clinical Study.” Neurology, vol. 60, no. 3, 11 Feb. 2003, pp. 500–502, 10.1212/01.wnl.0000044405.29988.e1; https://pubmed.ncbi.nlm.nih.gov/12578937/
    24. McMorris, T., et al. “Effect of Creatine Supplementation and Sleep Deprivation, with Mild Exercise, on Cognitive and Psychomotor Performance, Mood State, and Plasma Concentrations of Catecholamines and Cortisol.” Psychopharmacology, vol. 185, no. 1, 17 Jan. 2006, pp. 93–103, 10.1007/s00213-005-0269-z; https://pubmed.ncbi.nlm.nih.gov/16416332/
    25. McMorris, T., et al. “Effect of Creatine Supplementation and Sleep Deprivation, with Mild Exercise, on Cognitive and Psychomotor Performance, Mood State, and Plasma Concentrations of Catecholamines and Cortisol.” Psychopharmacology, vol. 185, no. 1, 17 Jan. 2006, pp. 93–103, 10.1007/s00213-005-0269-z; https://pubmed.ncbi.nlm.nih.gov/16416332/
    26. Fuld, J P. “Creatine Supplementation during Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease.” Thorax, vol. 60, no. 7, 1 July 2005, pp. 531–537, 10.1136/thx.2004.030452; https://pubmed.ncbi.nlm.nih.gov/15994258/
    27. Braegger, Christian P., et al. “Effects of Creatine Supplementation in Cystic Fibrosis: Results of a Pilot Study.” Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society, vol. 2, no. 4, 1 Dec. 2003, pp. 177–182; 10.1016/S1569-1993(03)00089-4; https://pubmed.ncbi.nlm.nih.gov/15463870/
    28. Rae, Caroline et al. “Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial.” Proceedings. Biological sciences vol. 270,1529 (2003): 2147-50. doi:10.1098/rspb.2003.2492; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1691485/
    29. Benton, David, and Rachel Donohoe. “The Influence of Creatine Supplementation on the Cognitive Functioning of Vegetarians and Omnivores.” The British Journal of Nutrition, vol. 105, no. 7, 2011, pp. 1100–5, 10.1017/S0007114510004733; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/influence-of-creatine-supplementation-on-the-cognitive-functioning-of-vegetarians-and-omnivores/E2D37729902DDFA6CFC85767AD0421FC
    30. Schilling, Brian K., et al. “Creatine Supplementation and Health Variables: A Retrospective Study.” Medicine & Science in Sports & Exercise, vol. 33, no. 2, 2001, pp. 183–188; https://journals.lww.com/acsm-msse/Fulltext/2001/02000/Creatine_supplementation_and_health_variables__a.2.aspx
    31. Hoffman, Jay, et al. “Effect of Creatine and ß-Alanine Supplementation on Performance and Endocrine Responses in Strength/Power Athletes.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 16, no. 4, Aug. 2006, pp. 430–446, 10.1123/ijsnem.16.4.430; https://pubmed.ncbi.nlm.nih.gov/17136944/
    32. Cook, Christian J, et al. “Skill Execution and Sleep Deprivation: Effects of Acute Caffeine or Creatine Supplementation – a Randomized Placebo-Controlled Trial.” Journal of the International Society of Sports Nutrition, vol. 8, no. 1, 16 Feb. 2011, 10.1186/1550-2783-8-2; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049131/
    33. Volek, Jeff S., et al. “The Effects of Creatine Supplementation on Muscular Performance and Body Composition Responses to Short-Term Resistance Training Overreaching.” European Journal of Applied Physiology, vol. 91, no. 5-6, 1 May 2004, pp. 628–637, 10.1007/s00421-003-1031-z; https://pubmed.ncbi.nlm.nih.gov/14685870/
    34. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
    35. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[1]:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    36. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    37. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    38. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    39. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    40. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    41. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    42. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    43. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
    44. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5; https://pubmed.ncbi.nlm.nih.gov/24760587/
    45. Schwedhelm, Edzard et al.; “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.”; British journal of clinical pharmacology vol. 65,1 (2008): 51-9.; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291275/
    46. Vijaya Juturu V., Komorowski, JR. 2002. US7576132B2 – “Arginine Silicate Inositol Complex and use Thereof.” The United States Patent and Trademark Office. https://patents.google.com/patent/US7576132
    47. Sandler, D., et al. June 2016. “Absorption of Bonded Arginine Silicate Compared to Individual Arginine and Silicon Components.” Journal of the International Society of Sports Nutrition vol. 13. https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0144-9
    48. Komorowski, J., Perez, S., & Sylla, S; “Arginase Inhibition by Inositol-stabilized Arginine Silicate (ASI; Nitrosigine); A Novel Mechanism by which ASI Enhances Arginine Bioavailability”; Poster Presentation. Retrieved from https://www.eventscribe.com/2018/Nutrition2018/ajaxcalls/PosterInfo.asp?efp=UlhTRFpZVVI0ODYw&PosterID=146640&rnd=0.1401379
    49. Rood-Ojalvo, S. et al. Sep. 2015. “The Benefits of Inositol-Stabilized Arginine Silicate as a Workout Ingredient.” Journal of the International Society of Sports Nutrition vol. 12(S1). https://jissn.biomedcentral.com/articles/10.1186/1550-2783-12-S1-P14
    50. Kalman, D. et al. June 2018. “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) On Cognitive Flexibility.” Nutrients https://blog.priceplow.com/wp-content/uploads/nitrosigine-cognitive-flexibility-issn-2018.pdf
    51. Evans, M., Zakaria, N., & Marzuk, M; “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) in Preventing the Decline of Cognitive Function Caused by Strenuous Exercise”; International Society of Sports Nutrition 2018 Conference; 2018; https://blog.priceplow.com/wp-content/uploads/nitrosigine-preventing-cognitive-decline-caused-by-strenuous-exercise.pdf
    52. Gills, Joshua L., et al. “Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults.” Nutrients, vol. 13, no. 12, 1 Dec. 2021, 10.3390/nu13124272; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8703995/
    53. Pietz J, Landwehr R, Kutscha A, Schmidt H, de Sonneville L, Trefz FK. Effect of high-dose tyrosine supplementation on brain function in adults with phenylketonuria. J Pediatr. 1995;127(6):936-943; https://pubmed.ncbi.nlm.nih.gov/8523192
    54. Attipoe, Selasi, et al. “Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature.” Military Medicine, vol. 180, no. 7, July 2015, pp. 754–765, 10.7205/milmed-d-14-00594; https://academic.oup.com/milmed/article/180/7/754/4160625
    55. Pomeroy, Diane E., et al. “A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel.” Nutrients, vol. 12, no. 2, 20 Feb. 2020, p. 545, 10.3390/nu12020545; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071459/
    56. Ripps, H. et al. Nov. 2012. “Review: Taurine: A “Very Essential Amino Acid.” Molecular Vision vol. 18. 2673-86. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501277/
    57. Chen, C. et al. Aug. 2019. “Roles of Taurine in Cognitive Function of Physiology, Pathologies, and Toxication.” Life Sciences vol. 15, 231; https://pubmed.ncbi.nlm.nih.gov/31220527/
    58. Waldron, M., et al. May 2018. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine vol. 48,5; 1247-53. https://pubmed.ncbi.nlm.nih.gov/29546641
    59. Guizoni, D. et al. Jan. 2020. “Modulation of Endothelium-Derived Nitric Oxide Production and Activity by Taurine and Taurine-Conjugated Bile Acids.” Nitric Oxide vol. 94,1; 48-53; https://www.sciencedirect.com/science/article/abs/pii/S1089860319302113
    60. Jong, Chian Ju, et al. “The Role of Taurine in Mitochondria Health: More than Just an Antioxidant.” Molecules, vol. 26, no. 16, 13 Aug. 2021, p. 4913, 10.3390/molecules26164913; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8400259/
    61. Sahlin, K. “Boosting Fat Burning With Carnitine: An Old Friend Comes Out from the Shadow.” Journal of Physiology vol. 589,Pt 7 (2011): 1509-10. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099008/
    62. Pooyandjoo, M., et al. “The Effect of (L-)Carnitine on Weight Loss in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.” Obesity Reviews, vol. 17, no. 10, 22 June 2016, pp. 970–976, 10.1111/obr.12436. https://pubmed.ncbi.nlm.nih.gov/27335245/
    63. Ruggenenti, Piero, et al. “Ameliorating Hypertension and Insulin Resistance in Subjects at Increased Cardiovascular Risk: Effects of Acetyl-L-Carnitine Therapy.” Hypertension (Dallas, Tex.: 1979), vol. 54, no. 3, 1 Sept. 2009, pp. 567–574, 10.1161/HYPERTENSIONAHA.109.132522. https://pubmed.ncbi.nlm.nih.gov/19620516/
    64. Sidossis, L, et al; “Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed”; American Journal of Physiology; 270(4 Pt 1):E733-8; April 1996; https://pubmed.ncbi.nlm.nih.gov/8928782
    65. Bonadonna, R; “Dose-dependent effect of insulin on plasma free fatty acid turnover and oxidation in humans”; The American Journal of Physiology; 259(5 Pt 1):E736-50; November 1990; https://pubmed.ncbi.nlm.nih.gov/2240211
    66. Fielding, Roger, et al. “L-Carnitine Supplementation in Recovery after Exercise.” Nutrients, vol. 10, no. 3, 13 Mar. 2018, p. 349, 10.3390/nu10030349. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872767/
    67. Krajcovicová-Kudlácková, M., et al. “Correlation of Carnitine Levels to Methionine and Lysine Intake.” Physiological Research, vol. 49, no. 3, 2000, pp. 399–402; https://pubmed.ncbi.nlm.nih.gov/11043928/
    68. Lombard, K A, et al. “Carnitine Status of Lactoovovegetarians and Strict Vegetarian Adults and Children.” The American Journal of Clinical Nutrition, vol. 50, no. 2, 1 Aug. 1989, pp. 301–306, 10.1093/ajcn/50.2.301; https://academic.oup.com/ajcn/article-abstract/50/2/301/4651007
    69. Krajcovicová-Kudlácková, M., et al. “Correlation of Carnitine Levels to Methionine and Lysine Intake.” Physiological Research, vol. 49, no. 3, 2000, pp. 399–402; https://pubmed.ncbi.nlm.nih.gov/11043928/
    70. Rebouche, Charles J. “Carnitine Function and Requirements during the Life Cycle.” The FASEB Journal, vol. 6, no. 15, Dec. 1992, pp. 3379–3386, 10.1096/fasebj.6.15.1464372; https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.6.15.1464372
    71. Malaguarnera, Mariano, et al. “Serum Carnitine Levels in Centenarians.” Clinical Drug Investigation, vol. 17, no. 4, 1999, pp. 321–327, 10.2165/00044011-199917040-00008; https://link.springer.com/article/10.2165/00044011-199917040-00008
    72. Malaguarnera, Mariano, et al. “L-Carnitine Treatment Reduces Severity of Physical and Mental Fatigue and Increases Cognitive Functions in Centenarians: A Randomized and Controlled Clinical Trial.” The American Journal of Clinical Nutrition, vol. 86, no. 6, 1 Dec. 2007, pp. 1738–1744, 10.1093/ajcn/86.5.1738; https://pubmed.ncbi.nlm.nih.gov/18065594/
    73. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849389/
    74. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483284/
    75. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010); https://link.springer.com/article/10.1186/1550-2783-7-5
    76. Norager, C. B., et al. “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.” Clinical Endocrinology, vol. 65, no. 2, Aug. 2006, pp. 223–228, 10.1111/j.1365-2265.2006.02579.x; https://pubmed.ncbi.nlm.nih.gov/16886964/
    77. Astrup, A, et al. “Caffeine: A Double-Blind, Placebo-Controlled Study of Its Thermogenic, Metabolic, and Cardiovascular Effects in Healthy Volunteers.” The American Journal of Clinical Nutrition, vol. 51, no. 5, 1 May 1990, pp. 759–767, 10.1093/ajcn/51.5.759; https://academic.oup.com/ajcn/article/51/5/759/4695347
    78. Keijzers, Gerben B., et al. “Caffeine Can Decrease Insulin Sensitivity in Humans.” Diabetes Care, vol. 25, no. 2, 1 Feb. 2002, pp. 364–369; https://care.diabetesjournals.org/content/25/2/364.long
    79. Hursel, R., et al. “The Effects of Catechin Rich Teas and Caffeine on Energy Expenditure and Fat Oxidation: A Meta-Analysis.” Obesity Reviews, vol. 12, no. 7, 2 Mar. 2011, pp. e573–e581, 10.1111/j.1467-789x.2011.00862.x; https://onlinelibrary.wiley.com/doi/full/10.1111/j.1467-789X.2011.00862.x
    80. Ras, Rouyanne T., et al. “Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis.” PLoS ONE, vol. 6, no. 3, 4 Mar. 2011, p. e16974, 10.1371/journal.pone.0016974; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048861/
    81. Hsu, Chung-Hua, et al. “Does Supplementation with Green Tea Extract Improve Insulin Resistance in Obese Type 2 Diabetics? A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.” Alternative Medicine Review: A Journal of Clinical Therapeutic, vol. 16, no. 2, 1 June 2011, pp. 157–163; https://pubmed.ncbi.nlm.nih.gov/21649457/ ( full text PDF)
    82. Venables, Michelle C, et al. “Green Tea Extract Ingestion, Fat Oxidation, and Glucose Tolerance in Healthy Humans.” The American Journal of Clinical Nutrition, vol. 87, no. 3, 1 Mar. 2008, pp. 778–784, 10.1093/ajcn/87.3.778; https://academic.oup.com/ajcn/article/87/3/778/4633440
    83. Brown, A. Louise, et al. “Effects of Dietary Supplementation with the Green Tea Polyphenol Epigallocatechin-3-Gallate on Insulin Resistance and Associated Metabolic Risk Factors: Randomized Controlled Trial.” British Journal of Nutrition, vol. 101, no. 6, 19 Aug. 2008, pp. 886–894, 10.1017/s0007114508047727; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819662/
    84. Jenkinson, Carl, et al. “Dietary Green and White Teas Suppress UDP-Glucuronosyltransferase UGT2B17 Mediated Testosterone Glucuronidation.” Steroids, vol. 77, no. 6, May 2012, pp. 691–695, 10.1016/j.steroids.2012.02.023; https://pubmed.ncbi.nlm.nih.gov/22429924/
    85. Satoh, K., et al. “Inhibition of Aromatase Activity by Green Tea Extract Catechins and Their Endocrinological Effects of Oral Administration in Rats.” Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, vol. 40, no. 7, 1 July 2002, pp. 925–933, 10.1016/s0278-6915(02)00066-2; https://pubmed.ncbi.nlm.nih.gov/12065214/

    Comments and Discussion (Powered by the PricePlow Forum)