Three Hot Muscle Building Ingredients to Look For in 2019

Innovation is what truly drives the growth of the supplement industry. While that innovation often comes in the form of marketing, models, and fancy packaging, we’re interested in real innovation – as in the science, research, and ingredients put into our supplements.

Muscle Building Ingredients

Looking for something new and next-gen beyond creatine, betaine, etc? Olympus Labs has just what you’re looking for

Each year, we see interesting new supplements and ingredients from our favorite brands, and we can’t help but get excited for them and their customers on a mission to push their natural limits. We’ve covered some muscle building supplements in the past, and are already on board with the standards like creatine, betaine, and of course plenty of diverse animal protein.

Today, we’ll be focusing on a few hot new ingredients for the natural athletes who are looking to build muscle. Not surprisingly, they’re coming from the most cutting-edge supplement brand on the market, Olympus Labs, a brand who’s introduced a lot of them to us.

Three next-level muscle builders to look out for in 2019

So what’s next? Below, we highlight three muscle-building ingredients you need to be on the lookout for in 2019:

  • Urolithin B,
  • Anacyclus pyrethrum, and
  • Korean Mistletoe.

The first and last of these two potent ingredients are gaining steam fast, and they might be on the back label of your go-to supplements in the near future! As for anacyclus, it’s set to make a comeback after some supply issues, and now has some excellent formulations put around it.

Since the Heroes at Olympus Labs is behind these ingredients as well as this post, you can subscribe to our OL news alerts and then let’s get on to business:

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  1. Urolithin B

    mTOR, or mammalian target of rapamycin, is an incredibly anabolic pathway that we need to take advantage of to reach our fullest potential. It’s activated by intense resistance training and doses of protein (especially the top-priority BCAA, leucine)… but are there other ways to boost mTOR signaling? Turns out there are:

    Ellagic Acid Benefits

    When it comes to Urbolin’s benefits, is ellagic acid the name of the game?

    Ellagic acid is a polyphenol frequently found within fruits and vegetables, and it has many of the usual benefits that typical antioxidants tend to have.[1] However, this particular acid is ripe with urolithins A, B, C, and D, metabolites that have even more to offer.[1] Specifically, urolithin B has shown promise as an effective muscle-builder, which is why we think you may be seeing more of it soon!

    The “B” may stand for “bigger”…

    In a study from 2017, researchers tested mice myotubes (muscle fibers) that had been incubated with different concentrations of urolithins for 24 hours. They found that urolithin B increased the diameter of the muscle fibers, even at low doses![2] These fibers also showed increased anabolic properties five days after their original testing,[2] even though these effects were found to have a ceiling at a dosage of 15 µM. Not only did urolithin B seem to induce muscle growth, but it also downregulates the system responsible for muscle atrophy,[2] too!

    This same study also saw increased activation of the mTORC1 pathway, meaning it also may stimulate muscle hypertrophy.[2] If that’s not enough for you, these scientists tested protein synthesis in the urolithin B-saturated fibers, as well. They found an increase of protein synthesis of 96.1%.[2]

    Massacr3

    With a bottle that looks like this, you know it’s time to Massacr3 the gym

    The evidence is incredible, and although there’s not enough of it to support its use for humans,[3] it’s surely on it way. Touting increases of mTOR activation, muscle hypertrophy, and anabolism, we’re sure urolithin B is going to get it’s time to shine soon. So, if you see things like Punica granatum (pomegranate seed extract) or ellagic acid on new labels, get ready for steady hit of muscle growth!

    Supplements with Urolithin B

    Where can you find it? Both Olympus Labs Ep1logue and Olympus Labs Massacr3 have it (150mg each), in the form of a trademarked ingredient named “UroBolin”. These two can be stacked together for some insane workouts, since they both have VASO-6 (another ingredient introduced to us by Olympus) and then differentiate with Laxogenin and Epicatechin:

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  2. Anacyclus pyrethrum – testosterone-boosting herb

    Anacyclus Pyrethrum

    Staying natty? What’s more natural than this? (Image Courtesy Wikimedia)

    Anacyclus pyrethrum is yet another powerful herb coming from Ayurveda, the venerable herb medicinal practice with origins in India. It has been traditionally used to promote fertility,[4] and its ability to do so may be tied to the amount of bioactive alkylamides the herb holds.[5] It’s been around for quite some time, having originally been discovered in North Africa,[5] but its attention in the supplement space has been on-and-off. Based on some new formulations what its been seen to do, we think that’s about to change!

    Testosterone-boosting potential

    Where anacyclus will most likely be relevant is in testosterone-boosting products, as it shows definite promise in this area. Research published in 2012 was conducted in order to analyze the effects that anacyclus root extract had on androgens in mice. After four weeks, these scientists saw a significant increase in testosterone, follicle-stimulating hormone, and luteinizing hormone.[6] While this supports the notion of fertility benefits (both the luteinizing and follicle-stimulating hormones help in that department), the boost in overall testosterone cannot be overstated. The results were so definitive that the scientists concluded that the root offers androgenic potential and may improve male fertility.[6]

    Olympus Labs Test1fy

    If you’re ready to handle eight capsules, then you’re ready to Test1fy.

    Some slight cognition enhancement

    As nootropics seem to be among the fastest-growing product line in our industry, it’s worth mentioning that anacyclus has shown some brain-boosting effects. With the root being anecdotally referred to as a “brain tonic”,[7] scientists set out to validate the nickname. They found that anacyclus root extract showed protective effects against seizures and cognitive impairment,[7] displaying the promise of brain-protecting uses.

    In addition, an extract of the herb was tested on memory-impaired mice in 2012. Researchers found that anacyclus improves cognitive processes by enhancing both the acquiring of new memories and retaining of old memories.[8]

    Supplements with Anacyclus Pyrethrum

    Look no further than Olympus Labs Test1fy for this one — there’s a monster 3.2g dose with several incredible testosterone support ingredients (KSM-66, LJ100, Boron, and others):

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  3. Korean Mistletoe

    Another ingredient we’ve seen very little of, Korean Mistletoe (KME) may be in for a big 2019. A plant originally hailing from Korea, it’s been studied heavily for its potential in treating various catabolic diseases.[9] However, it may have some other benefits which are much more relevant to our industry:

    Muscle-building promoter

    Korean Mistletoe Muscle

    This study was done on elderly to prevent muscle-wasting, so keep that in mind, but when it comes to muscle mass, Korean Mistletoe worked!

    In a comprehensive study published in 2012, researchers were interested in the effects Korean Mistletoe had in terms of muscle hypertrophy. They used mice myofibers saturated with KME, in addition to mice that had been fed long-term with the plant. Results showed the KME upregulated genes responsible for muscle hypertrophy (GLUT4 and PGC-1α), while also

    reducing the activity of those linked to muscle atrophy (atrogin-1).[9] The animal model showed even more tangible results, as the mice that were fed KME had higher muscle weight retention and even increased grip strength.[9]

    So there was something to be considered here. What about humans? The next step is to give it to elderly who are at risk for muscle atrophy.

    Olympus Labs Logo

    What’s your story? Olympus Labs has three hot muscle building ingredients as theirs.

    The next, more recent study supported the in vitro findings! In testing KME in the elderly, researchers administered a dose of either 1g/day dose, 2g/day, or placebo to subjects between 55 and 75 years of age. They recorded decreases in expression of genes linked to muscle atrophy, plus increases in activity of genes responsible for muscle hypertrophy.[10] In addition, they found an increase in of activity in the IGF1 pathway, suggesting even further benefits for muscle protein synthesis. Compared to placebo, the high-dose group saw significant increases in skeletal muscle mass and fat-free mass![10]

    We still need more action in healthy males, but based on what we’ve seen from Korean mistletoe extract as a next-gen muscle-builder, we’re very impressed. What’s so encouraging is that it seems to not only promote muscle growth, but also prevent muscle loss! What more could you ask for?

    How about fat loss?

    Olympus Labs K1ngs Slayer

    With one new muscle-building ingredient and three appetite-boosters, this supplement is sure to have you slaying — even in the kitchen!

    Because of some of the results we just discussed, you may be wondering whether KME has potential as a fat-loss agent. This makes sense, as having higher levels of muscle (such as the subjects in those studies) helps boost the metabolism and insulin sensitivity, encouraging easier fat loss. Luckily for us, there’s a bit of research showing more conclusive evidence!

    In research from 2013, the effect of Korean mistletoe extract on obesity and other adipogenic factors was tested. Mice were fed high-fat diet, in addition to a high dose of KME of 3g/kg/day, and tested after 15 weeks. Upon conclusion of the study, researchers saw a reduction in both body weight and fat mass, in addition to potentially promoting the use of brown adipose tissue for energy.[11] Scientists were quick to state the importance of the combination of KME and a high-fat diet, which may allude to some additional important to any keto dieters out there.

    Korean mistletoe extract looks to be a major factor in the supplement industry very soon. With a lot of research backing its muscle-building ability, and hopefully more supporting fat-loss potential, we absolutely love the future for this ingredient!

    Supplements with Korean Mistletoe

    Olympus Labs is once again the first to give us this next generation ingredient, and it comes in the intensely-named supplement, K1ngs Slayer. The Korean Mistletoe is paired with some appetite-boosting, HGH-enhancing ingredients, so you better be ready for bulking season with this one!

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Conclusion – look for these in new products and formulations!

EAA vs Leucine vs BCAA vs Placebo

In terms of aminos, nothing beats full-spectrum EAAs with tons of leucine!

The brands we know and love have two main goals to achieve each year. The first is obviously to make money, because there may not be another year if they don’t! But more importantly to us, they want to provide customers with impressive-yet-safe products that use quality, effective ingredients. Many customers want new flavors and packaging, but we want fresh ingredient labels. Olympus Labs does both.

Don’t get us wrong – we love our creatine, betaine, caffeine, citrulline, protein / EAA, beta alanine, etc.. and still recommend them (see our original muscle building supplements article). They have loads of research behind them, and that’s why they’re the go-to budget ingredients. But for natural athletes who are looking for more, there’s always something around the corner to at least consider. Are they the same as shooting up exogenously? Of course not. But does there seem to be some potential benefit from these new compounds? Absolutely. It all just depends on how much research you need to see before you’re willing to dive in – but this is a next generation article, after all.

Olympus Labs Dream Big and Dare to Fail

Olympus Labs Dreams Big – Do you Dare to Train to Failure?

Anacyclus has been seen before in products, but urolithin B (“UroBolin”) and Korean Mistletoe definitely caught us off guard at the end of 2018, and that’s why we follow Olympus Labs. We expect more research to continue coming out, and when that happens, we’ll stay on top of it to see where it all lands.

So whether you’re looking for a muscle-building product, a testosterone booster, or a little edge in losing that last bit of fat, there are definitely products out there that can help you out. However, in 2019, we expect urolithin B, anacyclus, and Korean mistletoe to state their presence. Be sure to keep your eyes peeled for our Olympus Labs news alerts, because with the respective promise each ingredient shows, they’ll be more prevalent very soon!

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About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is a biohacker with extensive experience in supplementation and dietary modification, whose personal expertise stems from several "n=1" experiments done on himself.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Francaux, M, and L Deldicque; “Using Polyphenol Derivatives to Prevent Muscle Wasting”; May 2018; https://www.ncbi.nlm.nih.gov/pubmed/29356695
  2. Rodriguez, Julie et al; “Urolithin B, a newly identified regulator of skeletal muscle mass”; Journal of Cachexia, Sarcopenia and Muscle; vol. 8,4; 2017; 583-597; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566634/
  3. Esposito D, Komarnytsky S, Shapses S, Raskin I; “Anabolic effect of plant brassinosteroid”; The FASEB Journal; 2011; 25(10):3708-3719; https://www.fasebj.org/doi/abs/10.1096/fj.11-181271
  4. Sharma, V, et al; “Androgenic and Spermatogenic Activity of Alkylamide-Rich Ethanol Solution Extract of Anacyclus Pyrethrum DC.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Jan. 2013; https://www.ncbi.nlm.nih.gov/pubmed/22473789
  5. Gautam, O., et al; “Anticonvulsant and Myorelaxation Activity of Anacyclus Pyrethrum DC. (Akarkara) Root Extract”; http://www.unisa.it/uploads/4978/015.gautam.pdf
  6. Sharma, Vikas, et al; “Androgenic and Spermatogenic Activity of Alkylamide‐Rich Ethanol Solution Extract of Anacyclus Pyrethrum DC.”; The Canadian Journal of Chemical Engineering; Wiley-Blackwell; 4 Apr. 2012; https://onlinelibrary.wiley.com/doi/full/10.1002/ptr.4697
  7. Pahuja, M, et al; “Root Extract of Anacyclus Pyrethrum Ameliorates Seizures, Seizure-Induced Oxidative Stress and Cognitive Impairment in Experimental Animals.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Feb. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21993359
  8. Sujith, K, et al; “Memory-Enhancing Activity of Anacyclus Pyrethrum in Albino Wistar Rats.”; NeuroImage; Academic Press; 1 July 2012; https://www.sciencedirect.com/science/article/pii/S222218081260067X
  9. Jeong, Juseong et al; “Korean mistletoe (Viscum album coloratum) extract regulates gene expression related to muscle atrophy and muscle hypertrophy”; BMC complementary and alternative medicine; vol. 17,1 68; 21 Jan. 2017; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5251312/
  10. Lim, N, et al; “A Combination of Korean Mistletoe Extract and Resistance Exercise Retarded the Decline in Muscle Mass and Strength in the Elderly: A Randomized Controlled Trial.”; NeuroImage; Academic Press; 11 Nov. 2016; https://www.sciencedirect.com/science/article/pii/S0531556516305071
  11. Jung, et al; “The Korean Mistletoe (Viscum Album Coloratum) Extract Has an Antiobesity Effect and Protects against Hepatic Steatosis in Mice with High-Fat Diet-Induced Obesity.”; Advances in Decision Sciences; Hindawi; 11 July 2013; https://www.hindawi.com/journals/ecam/2013/168207/

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