We Go Home No Sacrifice No Victory 2.0 Pre-Workout Is Live

Published on July 24, 2023 · Updated August 3, 2023 by Mike Roberto | No Comments

We all have a new brand we’ve got our eye on, and we think we’ve hit the jackpot with this one. We Go Home is an action-packed supplement company founded by Trung Nguyen, an extraordinarily talented US Army Ranger who deployed twice to Iraq and worked as a SWAT officer in the Chicago Police Department.

We Go Home No Sacrifice No Victory 2.0

With We Go Home, Trung has created a platform highlighting first responders and military, dedicating itself to giving our people in uniform the tools they ultimately need to… come home.

And now it’s time for some high-energy upgrades:

No Sacrifice No Victory: A Military-Grade Pre-Workout that’s PUMPED

Today, we’re focusing on We Go Home’s newest iteration of their pre-workout supplement, No Sacrifice No Victory (NSNV for short). Coming in both a stimulant and a stim-free version, NSNV 2.0 is an action-packed formula built with some of the strongest ingredients on the market, especially in terms of massive blood-rushing pumps.

It is military-grade, after all.

Llamacorn, Spicy MangoNada, and Tigers Blood

Along with the updated formula, we’re getting three new unique flavors: Llamacorn, Spicy MangoNada, and Tigers Blood. The non-stim version of NSNV 2.0 is coming in Llamacorn, whereas the latter two will be available in the stim version.

We’re going to dive into the nitty-gritty of how We Go Home NSNV 2.0 works, but first, let’s check the PricePlow for good We Go Home deals, and check out our video review of the new formula:

We Go Home No Sacrifice No Victory Pre-Workout – Deals and Price Drop Alerts

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Posts are sponsored in part by the retailers and/or brands listed on this page.

We Go Home NSNV 2.0 – How It Works

Each 28.8g scoop of NSNV 2.0 contains the following ingredients (note that the non-stim version contain all of the same ingredients minus the caffeine and theobromine):

Blood Flow & Pumps

  • L-Citrulline – 7000mg

    We Go Home No Sacrifice No Victory 2.0 Ingredients

    The We Go Home No Sacrifice No Victory 2.0 Ingredients — Remove the caffeine and theobromine if you have the stim-free version!

    In the past, arginine was widely considered the go-to nitric oxide (NO) precursor in the supplement industry. However, in recent years, citrulline has taken its place due to its superior bioavailability.[1] While arginine gets broken down by the intestines too quickly,[2-6] citrulline does not suffer this fate.

    Citrulline converts to arginine later on post-ingestion, then the arginine converts to nitric oxide.[7] That NO boost reduces arterial stiffness[8] and causes blood vessels to vasodilate, which increases blood flow[1,9] (and provides that epic “muscle pump” we’re chasing).

    Beyond the pumps, this blood flow brings nutrition to the muscles, and citrulline has been shown to provide:

    Better blood flow also brings more nutrients, and going beyond incredible pumps, the citrulline-driven vasodilation effect has been shown to provide other downstream benefits:[10-15]

    We Go Home No Sacrifice No Victory 2.0

    • Improved ATP production
    • Greater work output
    • Elevated high-intensity exercise performance
    • Better recovery
    • Increased oxygen uptake
    • Greater growth hormone (GH) release
    Nitric Oxide Synergy with the arginine in Nitrosigine below

    This is a great dose and we’re off to an amazing start, but what’s even greater is that we’re not even remotely done with nitric oxide. We still have full clinical doses of CellFlo6 and Nitrosigine (inositol stabilized arginine silicate – a better form of arginine), and we’ve seen arginine and citrulline actually complement each other synergistically![16-18] Why? Because citrulline is also an arginase inhibitor,[16-19] which means it prevents the breakdown of arginine, especially the extra arginine ingested.

    Citrulline Arginine Nitric Oxide Reaction

    The Arginine Citrulline Cycle with a breakout showing the arginine-to-nitric oxide reaction. Image courtesy Wikimedia with added biochemistry sources.[20,21]

    What this means is that We Go Home is providing us with a triple-whammy of nitric oxide boosting support for incredible blood flow and pumps.

  • Agmatine Sulfate – 1000mg

    Agmatine sulfate helps boost nitric oxide levels by preventing the breakdown of arginine via the inhibition of the arginase enzyme,[22] which is responsible for its degradation. Preclinical studies have shown that agmatine also directly influences NO production by upregulating endothelial nitric oxide synthase,[23,24] the enzyme responsible for generating NO in the arteries.

    An effective neuromodulator
    AstraGin Agmatine

    On top of its creatine boosting abilities, AstraGin can enhance agmatine’s absorption as well.[25]

    Apart from its role in NO production, agmatine sulfate has mood-boosting effects due to its neurotransmitter-like action in the central nervous system.[26] In fact, agmatine may actually be more influential when it comes to cognition:

    Once ingested, it binds to multiple receptors within the brain, triggering a number of interactions involving neurotransmitters.[27] Because it’s capable of stimulating multiple neural receptors, research suggests that agmatine can help alleviate symptoms of stress and anxiety.[28] This slightly euphoric environment can help elevate your cognition while training, allowing you to get zoned in and feeling good during your training session!

    Plays a hormonal role, too!

    Agmatine also interacts with your hormones. A study from 1995 found that agmatine stimulated luteinizing hormone (LH) release in mice, which ultimately helped boost testosterone levels.[29] Having a bit more testosterone floating around is definitely a good thing, as anyone reading this knows – it puts you in a higher anabolic state, ready to train hard and pack on lean muscle.

  • CellFlo6 – 600mg

    We Go Home EDC

    This is the way.

    CellFlo6 is a combination of six different green tea leaf extracts designed to induce vasodilation through a pathway different from Nitrosigine. Research shows that its components can significantly increase nitric oxide (NO) levels by interacting with nitric oxide synthase, promoting relaxation of endothelial cells in blood vessels and improving blood flow, which may enhance muscle pumps.[30,31]

    Moreover, it may also benefit liver health by reducing fat in liver tissue, as evidenced by a study showing significantly lower liver enzymes in individuals taking 500 milligrams of green tea extract for three months.[32-37]

    We often call green tea extract a “metabolic Swiss army knife” — yet with CellFlo6, the constituents used are those that target inducing a nitric oxide boost.

  • Sea Salt (39% yielding 350mg) (898mg)

    Sodium is an essential electrolyte mineral necessary for proper muscle function, peak performance, and recovery.[38,39] We Go Home goes big with 898 milligrams of sea salt, yielding 350 milligrams of sodium.

    While sodium still sometimes receives negative attention, it plays a vital role in maintaining optimal muscle function and overall athletic performance and should not be excessively restricted in the diet. Athletes need to understand its critical importance in health and performance.[39]

Strength, Power, & Peak Performance

  • Beta Alanine – 5000mg

    Beta-alanine has a rich history as an endurance aid and has been a staple in the nutritional supplement industry from its early days. We Go Home has decided to go big with an extra kick – normally we see 3.2 grams, but here we have 5! We’ll explain how this can help even more, but first let’s get into what beta alanine does:

    Beta Alanine Total Work Done

    Beta alanine leads to more work done, which can lead to gains if you take advantage of them!

    When beta-alanine combines with L-histidine, it forms carnosine, a dipeptide molecule abundantly present in muscle tissue. Carnosine plays a vital role in muscles as a proton buffer, assisting in the removal of acids like lactic acid, a waste product that leads to muscular fatigue when it accumulates.[40]

    For over a decade, we’ve known how successful this strategy is: Two separate meta-analyses (one in 2012[41] and another in 2016[42]) have supported beta alanine’s use in numerous athletic endeavors, covering 40 studies with over 1400 participants and 70 different exercises. The most recent conclusion is that beta alanine can support an increase overall exercise capacity in exercises ranging from 30 seconds to 10 minutes.[42]

    A 5 gram dose!
    Beta Alanine Carnosine

    Early mouse studies showed that oral beta alanine supplementation increased muscle carnosine content.[43] Subsequent human research showed that this increases endurance

    So why the extra dose?! Aside from the increased experience (discussed below), we need to realize that our goal is to get to carnosine saturation faster. An early study in 2006 showed that a “double” dose of beta alanine (6.4 grams per day) led to greater carnosine over the course of four weeks.[43] There are also at least three studies using this dose showing incredible results,[44-46] and another demonstrating improved inflammation markers in elite athletes.[47]

    While we don’t have 6.4 grams here and won’t/shouldn’t quote the exact gains from those studies, the point is, more beta alanine leads to more carnosine, and more carnosine leads to more endurance.

    Those tingles…

    Some may ask about the tingling sensation that you get when taking beta alanine. This is known as paresthesia[48] but an in-depth safety analysis showed the ingredient to be very safe and non-toxic.[49] Clearly this is a sensation that Trung enjoys — we often use it as our alert that it’s time to get moving.

  • Malic Acid – 3000mg

    Malic acid is required for the Krebs cycle, which is an extremely important element of your body’s cellular energy production.[50] Combined with citrulline, the duo do a fantastic job at improving aerobic efficiency,[51] and making sure you have the energy you need on tap.

    We Go Home

    In a way, we can actually consider this formula to be better than 10 grams of 2:1 citrulline malate (since we have 10 grams total, but it’s 7 grams of citrulline and 3 grams of malic acid).

    Many companies won’t put malic acid into the active ingredients, often stuffing it into the “other ingredients” area. It’s used for flavor and tartness, after all. However, we do like how it supports the Krebs cycle, and there have been many studies demonstrating citrulline malate’s efficacy at even lower doses than this[52] (and all of the “citrulline malate” on the market is really just citrulline and malic acid like we have here anyway).

    Long story short, there’s a lot of support for including malic acid with your citrulline, so you might as well label it as an active ingredient and tell us the dose!

  • Betaine Anhydrous – 2500mg

    Betaine Muscle

    A landmark 2013 study showed that 2.5 grams of betaine every day can have profound effects on body mass and strength[53,54]

    Betaine (in this formula betaine anhydrous), also known as trimethylglycine (TMG), is an ergogenic aid with distinct mechanisms from beta-alanine. One of its vital mechanisms of action is increasing adenosine triphosphate (ATP) production and improving mitochondrial respiration, contributing to enhanced cellular function and improved athletic and cognitive performance[55].

    Acting as a potent methyl donor, betaine carries methyl groups (CH3) to locations within the body for cellular-metabolic processes, making it one of the most powerful methyl donors identified.[56,57] Betaine supplementation has been shown to decrease homocysteine levels, which is crucial for cardiovascular health, as high homocysteine levels can increase the risk of cardiovascular disease.[58,59]

    Betaine also functions as an osmolyte, influencing biological fluids by manipulating osmotic pressure around cells, leading to cellular hyperhydration. This hyperhydration enhances performance by facilitating cellular access to nutrients[60,61] and increasing cell resistance to heat stress.[62]

    So what does this all mean? Better performance and gains:

    Betaine’s support in performance and body composition

    Over the years, several performance-based research studies have been performed with this 2.5 gram dose of betaine, showing benefits in terms of power, time-to-exhaustion, sprint performance, and related biomarkers.[63-66]

    Then in 2013, a research team showed that body composition can significantly improve as well — with more muscle gained and fat lost at the same time thanks to betaine compared to placebo![53,54]

    That same research team then showed improved fat loss in women specifically![67] This was also backed up by a solid meta-analysis on six studies showing that betaine consistently reduces fat mass.[68]

    Long story short, betaine is an incredible ergogenic aid, and we’re happy to see it in any pre-workout supplement.

  • Nitrosigine – 1500mg

    Nitrosigine stands as one of the most advanced and effective nitric oxide-promoting ingredients available in the nutritional supplement market today. It is a patented blend of arginine combined with inositol and silica, commonly referred to as inositol-stabilized arginine silicate (ASI) on supplement labels.[69]

    When compared to other nitric oxide-promoting ingredients like L-arginine, in-vitro research has demonstrated that Nitrosigine (ASI) can deliver a more significant boost in nitric oxide (NO).[70] Like the citrulline it’s partnered with, Nitrosigine works as an arginase inhibitor, helping to keep the breakdown of arginine at bay.[71]

    1500 milligrams is the dose that’s been used in human clinical trials. In terms of blood flow, one study found that this dose increased flow-mediated dilation in the arteries by an incredible 31%.[72] It took 8 grams of citrulline malate to get roughly the same effect… and we basically have more than that in No Sacrifice No Victory too!

    Citrulline Malate vs. Nitrosigine

    But Nitrosigine’s blood flow isn’t just to the muscles — it’s to the brain:

    Nitrosigine’s cognitive support
    Nitrosigine Working Memory Study

    A new study published in late 2021 showed that Nutrition21’s Nitrosigine improves working memory and cognitive function in healthy young adults[73]

    First, researchers found that Nitrosigine prevented the cognitive decline that occurs after hard training.[74,75] We don’t need to tell you how important this is for We Go Home’s user base — there is absolutely no room for “cognitive slippage” at any point of a busy day in the field.

    Even better, the research showed that cognitive benefits may begin as quickly as 15 minutes after ingestion![74]

    Additional research has shown improvements with multitasking,[76] and another found improved short-term memory performance.[73]

    Put alongside citrulline, agmatine, and VASO6, it’s obvious that We Go Home is serious about pumps and blood flow.

  • Senactiv (50mg)

    Senactiv is an ingredient made by NuLiv Science that functions as a senolytic,[77] a type of compound that promotes the replacement of deteriorating cells.[78] This allows for new cell generation, benefiting overall health and muscle growth, particularly in skeletal muscle cells. Research on the ginsenosides within Senactiv demonstrated reduced inflammation and enhanced glycogen replenishment in muscle tissue compared to placebo.[79]

    Combining Senactiv with AstraGin, another ingredient by NuLiv Science, results in a synergistic effect, further enhancing their individual benefits. The combination of these ingredients has gained support for its potential to improve overall performance, including endurance, muscle regeneration, and energy production.[78-84]

Mind & Muscle Connection

  • L-Tyrosine – 3000mg

    Eddie Hall Myprotein THE Pre-workout Supplement Tyrosine

    Tyrosine has a big impact on neurotransmitters!

    L-Tyrosine, an amino acid, serves as a valuable tool for managing the stress associated with training and body recomposition. And here we have a high, above-average dose of 3 grams to pair with the nootropic benefits of Nitrosigine, caffeine (if using the stim version), and choline inside!

    Tyrosine acts as a precursor to catecholamine neurotransmitters, such as dopamine, adrenaline, and noradrenaline,[85-87] which play vital roles in focus, motivation, energy regulation, and even appetite suppression.[88]

    Additionally, L-Tyrosine plays a crucial role in thyroid hormone synthesis as a precursor to triiodothyronine (T3) and thyroxine (T4), supporting optimal thyroid function and preventing downregulation due to the stress of exercise.[89-92] This is particularly beneficial for individuals on calorie-restricted diets, as dieting has also been shown to impact thyroid function negatively[93].

    Furthermore, L-tyrosine has demonstrated effectiveness in restoring cognitive function in sleep-deprived individuals, making it a useful tool for countering the effects of sleep deprivation.[94,95] We Go Home users will be proud to know that much of that knowledge was obtained from research experiments on members of the US armed forces.

  • Choline DL-Bitartrate – 1000mg

    Choline plays a crucial role in building and maintaining cellular membranes, which are essential for cellular health and optimal function by enclosing the contents of cells and regulating nutrient entry while blocking toxins and pathogens.[96] Additionally, choline serves as a precursor to the neurotransmitter acetylcholine, known as the “learning neurotransmitter” crucial for memory consolidation and the conversion of short-term memories into long-term memories.[97]

    Choline’s relevance in fat-burning supplements stems from its role in metabolizing fat and promoting carnitine retention, which aids in fat metabolism.[60,61,98-102]

    Another solid dose here, to pair with that large dose of tyrosine.

  • Theobromine (150mg)

    Theobromine Half Life

    Taken from a patent application, this is actually about its antitussive effect, but shows that theobromine certainly lasts a while.

    Theobromine is a methylxanthine alkaloid similar to caffeine, and it exerts stimulant, vasodilatory, and bronchodilatory effects. Like caffeine, theobromine inhibits phosphodiesterase, leading to increased levels of cAMP and a higher metabolic rate. Compared to caffeine, theobromine has superior vasodilatory effects, and despite being a stimulant, it can actually lower blood pressure and heart rate.

    It is sometimes combined with caffeine to counteract caffeine’s hypertensive effect, providing the benefits of caffeine without as much cardiovascular risk. Theobromine achieves this by upregulating nitric oxide (NO) production, and due to its longer half-life compared to caffeine, it can help alleviate caffeine withdrawal symptoms as its effects gradually wear off.[103-110]

    Note: Theobromine is not in the stimulant-free version.

  • Huperzine A 1% (20mg)

    Huperzia serrata extracts are standardized for huperzine A, a bioactive compound that inhibits the enzyme acetylcholinesterase. By blocking this enzyme, huperzine A increases the levels of acetylcholine in the brain,[111,112] which is essential for learning, cognitive performance, and long-term potentiation. Moreover, huperzine A can protect brain mitochondria from oxidative stress[113] and promote the growth of new neurons in the hippocampus.[114]

Flow Energy Complex (~360mg total caffeine in stim version)

  • We Go Home Zero Dark Thirty

    Take too much caffeine too late in the day? Then check out We Go Home’s Zero Dark Thirty to help put you back down for the night

    Caffeine, a widely used stimulant, not only boosts mental alertness but also increases the body’s production of cellular energy. It inhibits the enzyme phosphodiesterase, leading to increased levels of cyclic adenosine monophosphate (cAMP),[115,116] which signals cells to produce more ATP, thus boosting cellular metabolism and calorie burning.[117]

  • In addition to 250 milligrams of caffeine anhydrous, NSNV 2.0 contains 100 milligrams of di-caffeine malate (73% caffeine by weight), a combination of caffeine and malic acid. This combination results in a nice, more time-released caffeine experience, helping to take the edge off.
  • As a cherry on top, NSNV contains 75 milligrams of caffeine citrate (50% caffeine by weight), which is anecdotally a faster acting form of caffeine.

    • This yields ~360 milligrams of total caffeine yield providing a great caffeine release spectrum.

Absorption Optimizer & Gut Health

  • AstraGin (50mg)

    AstraGin Citrulline

    One of AstraGin’s most popular use-cases is its ability to enhance citrulline absorption[25] – especially right when we’d want it: during our workout!

    AstraGin, a popular bioavailability-boosting ingredient created by NuLiv Science, is a combination of bioactive astragalosides and ginsenosides extracted from Astragalus membranaceus and Panax notoginseng.[118-122]

    It has been shown to enhance nutrient uptake and improve the bioavailability of other ingredients in the supplement’s formula. Specifically, AstraGin enhances the absorption of citrulline during workouts, thereby amplifying the citrulline pumps.[25]

    AstraGin works by upregulating mRNA and important transporters responsible for sodium-dependent glucose uptake control, proper glucose level maintenance, and amino acid shuttling. Additionally, AstraGin may improve gut function and permeability, potentially benefiting the absorption of various ingredients in No Sacrifice No Victory.

    AstraGin Nutrient Transport Study Results

    AstraGin hits nutrient transportation from multiple angles!

    But not to be outdone, We Go Home added even more ingredient amplification:

  • Bioperine (10mg)

    BioPerine is an extract derived from black pepper that undergoes standardization to ensure a consistent amount of an alkaloid known as piperine. Piperine, in turn, serves as a bioavailability enhancer, enhancing the absorption of various nutritional supplements when taken in combination with it.[123-126]

    This means that piperine helps your body effectively absorb and utilize the nutrients present in the supplements. It achieves this by inhibiting digestive enzymes responsible for breaking down nutrients before they can be absorbed into the bloodstream through the intestines.[127]

    Bioperine

    Bioperine is the trusted, trademarked form of black pepper extract that promises 95% or greater piperine, the part of black pepper with all the activity!

    Additionally, piperine has the ability to upregulate a protein known as glucose transporter 4 (GLUT4).[128] GLUT4 is involved in facilitating the disposal of glucose in the body.[129] By enhancing the function of GLUT4, piperine contributes to improved liver health and aids in combating oxidative stress.[130]

Additional Ingredients

  • B12 Methylcobalamin (0.05mg)

    Methylcobalamin, a specific variant of vitamin B12, is the favored form of B12 that we utilize.[131] Functioning as a methyl donor, it plays a crucial role in supporting metabolic processes that rely on methylation. Moreover, methylcobalamin has the potential to elevate energy levels and even contribute to the reduction of muscle damage.

    Now that’s a pumped-up pre-workout supplement.

All We Go Home NSNV 2.0 flavors

We Go Home Supplements

Check out our up-to-date list of flavors below for the stim-based version:

    And here’s the flavor list for stimulant-free:

      A brand with a mission

      We love to find new brands that have a purpose. A mission.

      The folks at We Go Home certainly know what a mission is. Nobody takes fitness quite as seriously as the United States military – after all, it ultimately comes down to life versus death. In the case of We Go Home, this rigorous focus on what actually works has yielded incredible results with NSNV 2.0.

      Finally, we civilians will have access to military-grade supplements. We plan on getting Trung on the PricePlow Podcast shortly, but until then, the best way to get to know Trung is to listen to his legendary episode on the Zero Limits Podcast:

      We Go Home: Be an Asset

      Trung immigrated to Chicago at 3 years old from Vietnam post war and had an interaction with a police officer at the age of 14 in the hood that ultimately left a good impression on him with him altering the direction in which his life was headed. Trung enlisted into the US Army with a ranger contract. Trung completed ranger training got his tan beret and posted to 2nd Battalion 75th Ranger Regiment. Trung deployed twice to Iraq and was involved in multiple direct action operations. Upon return of his second deployment he discharged and pursed a career as a police officer starting in Chicago and then moving to the LAPD. After about two years he moved back to Chicago PD and successfully became a CPD SWAT OFFICER. Trung also talks about life in law enforcement and his methods and mindset for continual training and progression. We also discuss his tribute project and website, “WE GO HOME”.[Listen to Podcast]

      We Go Home No Sacrifice No Victory Pre-Workout – Deals and Price Drop Alerts

      Get Price Alerts

      No spam, no scams.

      Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

      Posts are sponsored in part by the retailers and/or brands listed on this page.

      About the Author: Mike Roberto

      Mike Roberto

      Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

      Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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      References

      1. Schwedhelm, Edzard et al.; “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.”; British journal of clinical pharmacology vol. 65,1 (2008): 51-9.; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291275/
      2. Agarwal, Umang et al; “Supplemental Citrulline Is More Efficient Than Arginine in Increasing Systemic Arginine Availability in Mice.”; The Journal of nutrition; vol. 147,4; 2017; 596-602; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5368575/
      3. O’sullivan, D., et al. “Hepatic Zonation of the Catabolism of Arginine and Ornithine in the Perfused Rat Liver.” Biochemical Journal, vol. 330, no. Pt 2, 1 Mar. 1998, p. 627, 10.1042/bj3300627; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1219183/
      4. van de Poll, Marcel CG, et al. “Interorgan Amino Acid Exchange in Humans: Consequences for Arginine and Citrulline Metabolism.” The American Journal of Clinical Nutrition, vol. 85, no. 1, 1 Jan. 2007, pp. 167–172, 10.1093/ajcn/85.1.167; https://pubmed.ncbi.nlm.nih.gov/17209193/
      5. Castillo, L, et al. “Splanchnic Metabolism of Dietary Arginine in Relation to Nitric Oxide Synthesis in Normal Adult Man.” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 1, 1 Jan. 1993, pp. 193–197; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45626/
      6. Wu, Guoyao. “Intestinal Mucosal Amino Acid Catabolism.” The Journal of Nutrition, vol. 128, no. 8, 1 Aug. 1998, pp. 1249–1252, 10.1093/jn/128.8.1249; https://academic.oup.com/jn/article/128/8/1249/4722724
      7. Stamler, Jonathan S., and Gerhard Meissner. “Physiology of Nitric Oxide in Skeletal Muscle.” Physiological Reviews, vol. 81, no. 1, 1 Jan. 2001, pp. 209–237, 10.1152/physrev.2001.81.1.209; https://journals.physiology.org/doi/full/10.1152/physrev.2001.81.1.209
      8. Ochiai, Masayuki, et al; “Short-Term Effects of L-Citrulline Supplementation on Arterial Stiffness in Middle-Aged Men.”; International Journal of Cardiology; U.S. National Library of Medicine; 8 Mar. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21067832
      9. Archer, S L, et al. “Nitric Oxide and CGMP Cause Vasorelaxation by Activation of a Charybdotoxin-Sensitive K Channel by CGMP-Dependent Protein Kinase.” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 16, 1994, pp. 7583–7, 10.1073/pnas.91.16.7583; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC44446/
      10. Bailey, SJ et al.; “l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.”; Journal of Applied Physiology; 119(4) pp. 385-395; 2015; https://journals.physiology.org/doi/full/10.1152/japplphysiol.00192.2014
      11. Giannesini B., et. al.; European Journal of Pharmacology; “Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle;” September 2011; http://www.ncbi.nlm.nih.gov/pubmed/21664351
      12. Perez-Guisado J, Jakeman PM; Journal of Strength and Conditioning; “Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness;” May 2010; http://www.ncbi.nlm.nih.gov/pubmed/20386132
      13. Hickner RC. et. al.; Medicine and Science in Sports and Exercise; “L-citrulline reduces time to exhaustion and insulin response to a graded exercise test;” 2006; http://www.ncbi.nlm.nih.gov/pubmed/16679980
      14. Sureda, Antoni, et al. “L-Citrulline-Malate Influence over Branched Chain Amino Acid Utilization during Exercise.” European Journal of Applied Physiology, vol. 110, no. 2, 25 May 2010, pp. 341–351, 10.1007/s00421-010-1509-4; https://pubmed.ncbi.nlm.nih.gov/20499249/
      15. Rhim, Hye Chang, et al. “Effect of Citrulline on Post-Exercise Rating of Perceived Exertion, Muscle Soreness, and Blood Lactate Levels: A Systematic Review and Meta-Analysis.” Journal of Sport and Health Science, Feb. 2020, 10.1016/j.jshs.2020.02.003. https://www.sciencedirect.com/science/article/pii/S2095254620300168
      16. Morita, Masahiko, et al; “Oral Supplementation with a Combination of L-Citrulline and L-Arginine Rapidly Increases Plasma L-Arginine Concentration and Enhances NO Bioavailability.”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 7 Nov. 2014; https://www.sciencedirect.com/science/article/pii/S0006291X14018178
      17. Suzuki, Takashi, et al. “The Effects on Plasma L-Arginine Levels of Combined Oral L-Citrulline and L-Arginine Supplementation in Healthy Males.” Bioscience, Biotechnology, and Biochemistry, vol. 81, no. 2, 26 Sept. 2016, pp. 372–375, doi:10.1080/09168451.2016.1230007; https://academic.oup.com/bbb/article/81/2/372/5955995
      18. Suzuki, Izumi, et al. “A Combination of Oral L-Citrulline and L-Arginine Improved 10-Min Full-Power Cycling Test Performance in Male Collegiate Soccer Players: A Randomized Crossover Trial.” European Journal of Applied Physiology, vol. 119, no. 5, 16 Feb. 2019, pp. 1075–1084, doi:10.1007/s00421-019-04097-7; https://link.springer.com/article/10.1007/s00421-019-04097-7
      19. El-Bassossy, Hany M., et al. “Arginase Inhibition Alleviates Hypertension Associated with Diabetes: Effect on Endothelial Dependent Relaxation and NO Production.” Vascular Pharmacology, vol. 57, no. 5-6, Nov. 2012, pp. 194–200, doi:10.1016/j.vph.2012.01.001; https://www.sciencedirect.com/science/article/abs/pii/S1537189112000031
      20. Bryan, Nathan S., and Jack R. Lancaster. “Nitric Oxide Signaling in Health and Disease.” Nitrite and Nitrate in Human Health and Disease, 2017, pp. 165–178, 10.1007/978-3-319-46189-2_13; https://link.springer.com/chapter/10.1007/978-3-319-46189-2_13
      21. Ghellam, Mohamed & Koca, Ilkay. “Nitrate in All Respects: Metabolic Pathways, Sources, and Human Health”; Derleme Review; Volume 3, Issue 2, 120 – 130, May 27, 2019; https://www.researchgate.net/publication/333405488_Nitrate_in_All_Respects_Metabolic_Pathways_Sources_and_Human_Health
      22. Legaz, M. et al. Feb. 1983. “Endogenous Inactivators of Arginase, L-Arginine Decarboxylase, and Agmatine Amidinohydrolase in Evernia prunastri Thallus.” Plant Physiology vol. 71,1; 300-2. https://pubmed.ncbi.nlm.nih.gov/16662821
      23. Morrissey J. et al. Jan. 1997. “Agmatine Activation of Nitric Oxide Synthase in Endothelial Cells.” Proceedings of the Association of American Physicians vol. 109,1;51-7. https://pubmed.ncbi.nlm.nih.gov/9010916/
      24. Chin Hee Mun, et al. Regulation of Endothelial Nitric Oxide Synthase by Agmatine after Transient Global Cerebral Ischemia in Rat Brain. Vol. 43, no. 3, 1 Jan. 2010, pp. 230–230, doi:10.5115/acb.2010.43.3.230; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015041/
      25. NuLiv Science; AstraGin Product Dossier; https://docdro.id/rA01t9O
      26. Freitas, Andiara E., et al. “Agmatine, a Potential Novel Therapeutic Strategy for Depression.” European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, vol. 26, no. 12, 1 Dec. 2016, pp. 1885–1899, 10.1016/j.euroneuro.2016.10.013; https://pubmed.ncbi.nlm.nih.gov/27836390/
      27. Uzbay, Tayfun I; “The Pharmacological Importance of Agmatine in the Brain.”; Neuroscience and Biobehavioral Reviews; U.S. National Library of Medicine; Jan. 2012; https://www.ncbi.nlm.nih.gov/pubmed/21893093
      28. Halaris, Angelos, and John Plietz; “Agmatine : Metabolic Pathway and Spectrum of Activity in Brain.”; CNS Drugs; U.S. National Library of Medicine; 2007; https://www.ncbi.nlm.nih.gov/pubmed/17927294
      29. Kalra, S P, et al; “Agmatine, a Novel Hypothalamic Amine, Stimulates Pituitary Luteinizing Hormone Release in Vivo and Hypothalamic Luteinizing Hormone-Releasing Hormone Release in Vitro.”; Neuroscience Letters; U.S. National Library of Medicine; 21 July 1995; https://www.ncbi.nlm.nih.gov/pubmed/7478229
      30. Lorenz M, Wessler S, Follmann E, et al; “A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation”; J Biol Chem; 2004; 279(7):6190-6195; https://www.jbc.org/content/279/7/6190.full.pdf+html
      31. Kim JA, Formoso G, Li Y, et al; “Epigallocatechin gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and fyn”; J Biol Chem; 2007; 282(18):13736-13745; https://www.jbc.org/content/282/18/13736.full.pdf+html
      32. Hursel, R., et al. “The Effects of Catechin Rich Teas and Caffeine on Energy Expenditure and Fat Oxidation: A Meta-Analysis.” Obesity Reviews, vol. 12, no. 7, 2 Mar. 2011, pp. e573–e581, 10.1111/j.1467-789x.2011.00862.x; https://onlinelibrary.wiley.com/doi/full/10.1111/j.1467-789X.2011.00862.x
      33. Ras, Rouyanne T., et al. “Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis.” PLoS ONE, vol. 6, no. 3, 4 Mar. 2011, p. e16974, 10.1371/journal.pone.0016974; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048861/
      34. Hsu, Chung-Hua, et al. “Does Supplementation with Green Tea Extract Improve Insulin Resistance in Obese Type 2 Diabetics? A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.” Alternative Medicine Review: A Journal of Clinical Therapeutic, vol. 16, no. 2, 1 June 2011, pp. 157–163; https://pubmed.ncbi.nlm.nih.gov/21649457/ (full text PDF)
      35. Venables, Michelle C, et al. “Green Tea Extract Ingestion, Fat Oxidation, and Glucose Tolerance in Healthy Humans.” The American Journal of Clinical Nutrition, vol. 87, no. 3, 1 Mar. 2008, pp. 778–784, 10.1093/ajcn/87.3.778; https://academic.oup.com/ajcn/article/87/3/778/4633440
      36. Brown, A. Louise, et al. “Effects of Dietary Supplementation with the Green Tea Polyphenol Epigallocatechin-3-Gallate on Insulin Resistance and Associated Metabolic Risk Factors: Randomized Controlled Trial.” British Journal of Nutrition, vol. 101, no. 6, 19 Aug. 2008, pp. 886–894, 10.1017/s0007114508047727; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819662/
      37. Pezeshki A, Safi S, Feizi A, Askari G, Karami F. The Effect of Green Tea Extract Supplementation on Liver Enzymes in Patients with Nonalcoholic Fatty Liver Disease. Int J Prev Med. 2016 Feb 1;7:28. doi: 10.4103/2008-7802.173051; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4763469/
      38. Strazzullo P., Leclercq C.; “Sodium.” Advanced Nutrition; March 2014; 5(2) 188-190; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951800/
      39. Valentine, V. 2007. “The Importance of Salt in the Athlete’s Diet.” Current Sports Medicine Reports vol. 6,4 (2007): 237-40. https://pubmed.ncbi.nlm.nih.gov/17617999/
      40. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
      41. Hobson, R M et al. “Effects of β-alanine supplementation on exercise performance: a meta-analysis.” Amino acids vol. 43,1 (2012): 25-37. doi:10.1007/s00726-011-1200-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
      42. Saunders, Bryan, et al. “β-Alanine Supplementation to Improve Exercise Capacity and Performance: A Systematic Review and Meta-Analysis.” British Journal of Sports Medicine, vol. 51, no. 8, 18 Oct. 2016, pp. 658–669; https://bjsm.bmj.com/content/51/8/658.long
      43. Harris, R. C., et al. “The Absorption of Orally Supplied β-Alanine and Its Effect on Muscle Carnosine Synthesis in Human Vastus Lateralis.” Amino Acids, vol. 30, no. 3, 24 Mar. 2006, pp. 279–289, doi:10.1007/s00726-006-0299-9.; https://pubmed.ncbi.nlm.nih.gov/16554972/
      44. Bellinger, Phillip M., and Clare L. Minahan. “The Effect Of β-Alanine Supplementation on Cycling Time Trials of Different Length.” European Journal of Sport Science, vol. 16, no. 7, 11 Dec. 2015, pp. 829–836, 10.1080/17461391.2015.1120782; https://pubmed.ncbi.nlm.nih.gov/26652037/
      45. Hobson, Ruth M., et al. “Effect of Beta-Alanine with and without Sodium Bicarbonate on 2,000-m Rowing Performance.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 23, no. 5, Oct. 2013, pp. 480–487, 10.1123/ijsnem.23.5.480; https://pubmed.ncbi.nlm.nih.gov/23535873/
      46. DE Camargo, Júlio Benvenutti Bueno, et al. “Beta-Alanine Supplementation for Four Weeks Increases Volume Index and Reduces Perceived Effort of Resistance-Trained Men: A Pilot Study.” International Journal of Exercise Science, vol. 14, no. 2, 2021, pp. 994–1003; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439704/
      47. Turcu, Ioan, et al. “Effect of 8-Week β-Alanine Supplementation on CRP, IL-6, Body Composition, and Bio-Motor Abilities in Elite Male Basketball Players.” International Journal of Environmental Research and Public Health, vol. 19, no. 20, 21 Oct. 2022, p. 13700, doi:10.3390/ijerph192013700; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603793/
      48. Liu, Q., et al. “Mechanisms of Itch Evoked by -Alanine.” Journal of Neuroscience, vol. 32, no. 42, 17 Oct. 2012, pp. 14532–14537, 10.1523/jneurosci.3509-12.2012; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491570/
      49. Dolan, Eimear, et al. “A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.” Advances in Nutrition, vol. 10, no. 3, 13 Apr. 2019, pp. 452–463, 10.1093/advances/nmy115; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520041/
      50. “Malic Acid: Uses, Side Effects, Interactions, Dosage, and Warning.” WebMD; https://www.webmd.com/vitamins/ai/ingredientmono-1495/malic-acid
      51. Bendahan, D. “Citrulline/Malate Promotes Aerobic Energy Production in Human Exercising Muscle.” British Journal of Sports Medicine, vol. 36, no. 4, 1 Aug. 2002, pp. 282–289, 10.1136/bjsm.36.4.282; https://bjsm.bmj.com/content/36/4/282
      52. Vårvik, Fredrik Tonstad, et al. “Acute Effect of Citrulline Malate on Repetition Performance during Strength Training: A Systematic Review and Meta-Analysis.” International Journal of Sport Nutrition and Exercise Metabolism, vol. 31, no. 4, 2021, pp. 1–9, doi:10.1123/ijsnem.2020-0295; https://journals.humankinetics.com/view/journals/ijsnem/31/4/article-p350.xml
      53. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
      54. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5; https://pubmed.ncbi.nlm.nih.gov/24760587/
      55. Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5. doi: 10.1016/j.bbrc.2014.12.005; https://pubmed.ncbi.nlm.nih.gov/25498545/
      56. Zhao, Guangfu et al. “Betaine in Inflammation: Mechanistic Aspects and Applications.” Frontiers in immunology vol. 9 1070. 24 May. 2018, doi:10.3389/fimmu.2018.01070 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976740/
      57. Craig, Stuart AS. “Betaine in Human Nutrition.” The American Journal of Clinical Nutrition, vol. 80, no. 3, 1 Sept. 2004, pp. 539–549, 10.1093/ajcn/80.3.539. https://www.sciencedirect.com/science/article/pii/S0002916522035602
      58. Ganguly, Paul, and Sreyoshi Fatima Alam. “Role of homocysteine in the development of cardiovascular disease.” Nutrition journal vol. 14 6. 10 Jan. 2015, doi:10.1186/1475-2891-14-6; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326479/
      59. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
      60. Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr. 2003;133(1):84-89. http://jn.nutrition.org/content/133/1/84.long
      61. Daily JW 3rd, Sachan DS. Choline supplementation alters carnitine homeostasis in humans and guinea pigs. J Nutr. 1995;125(7):1938-1944. https://www.ncbi.nlm.nih.gov/pubmed/7616311
      62. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
      63. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
      64. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
      65. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
      66. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
      67. Jason Michael Cholewa, et al; “The Effects of Chronic Betaine Supplementation on Body Composition and Performance in Collegiate Females: a Double-Blind, Randomized, Placebo Controlled Trial”; Journal of the International Society of Sports Nutrition; BioMed Central; 31 July 2018; https://jissn.biomedcentral.com/articles/10.1186/s12970-018-0243-x
      68. Gao, Xiang et al.; “Effect of Betaine on Reducing Body Fat—A Systematic Review and Meta-Analysis of Randomized Controlled Trials.”; Nutrients 2019, 11, 2480; https://www.mdpi.com/2072-6643/11/10/2480
      69. Vijaya Juturu V., Komorowski, JR. 2002. US7576132B2 – “Arginine Silicate Inositol Complex and use Thereof.” The United States Patent and Trademark Office. https://patents.google.com/patent/US7576132
      70. Ramaswamy, Lalitha et al. “Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo: Clearwater Beach, FL, USA. 9-11 June 2016.” Journal of the International Society of Sports Nutrition vol. 13, Suppl 1 33. 12 Sep. 2016, doi:10.1186/s12970-016-0144-9; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025820/#Sec129
      71. Komorowski, James, and Sara Perez Ojalvo. A Pharmacokinetic Evaluation of the Duration of Effect of Inositol-Stabilized Arginine Silicate and Arginine Hydrochloride in Healthy Adult Males. Vol. 30, 1 Apr. 2016, doi:10.1096/fasebj.30.1_supplement.690.17; https://faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fasebj.30.1_supplement.690.17
      72. Rogers, Jeffrey M et al. “Acute effects of Nitrosigine and citrulline malate on vasodilation in young adults.” Journal of the International Society of Sports Nutrition vol. 17,1 12. 24 Feb. 2020, doi:10.1186/s12970-020-00343-y; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041093/
      73. Gills, Joshua L., et al. “Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults.” Nutrients, vol. 13, no. 12, 1 Dec. 2021, 10.3390/nu13124272; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703995/
      74. Evans, M., Zakaria, N., & Marzuk, M; “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) in Preventing the Decline of Cognitive Function Caused by Strenuous Exercise”; International Society of Sports Nutrition 2018 Conference; 2018; https://blog.priceplow.com/wp-content/uploads/nitrosigine-preventing-cognitive-decline-caused-by-strenuous-exercise.pdf
      75. Evans, M. et al. July 2020. “Inositol-Stabilized Arginine Silicate Improves Post Exercise Cognitive Function in Recreationally Active, Healthy Males: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.” Journal of Exercise and Nutrition vol. 3,3; https://www.journalofexerciseandnutrition.com/index.php/JEN/article/view/69 (full-text PDF)
      76. Kalman, D., Hewlings, S., Sylla, S., Ojalvo, S., & Komorowski, J; “An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) on cognitive flexibility”; International Society of Sports Nutrition 2018 Conference; 2018; https://blog.priceplow.com/wp-content/uploads/nitrosigine-cognitive-flexibility-issn-2018.pdf
      77. Kuo, Chia-Hua, et al; “Anti-aging method and composition”. United States Patent and Trademark Office. Patent #US10806764B2; 20 Oct. 2020; https://patents.google.com/patent/US10806764B2/en
      78. Childs, Bennett G., et al. “Senescent Cells: An Emerging Target for Diseases of Ageing.” Nature Reviews Drug Discovery, vol. 16, no. 10, 21 July 2017, pp. 718–735, 10.1038/nrd.2017.116; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942225/
      79. Hou, C.-W., Lee, S.-D., et. al. Plos One. “Improved Inflammatory Balance of Human Skeletal Muscle during Exercise after Supplementations of the Ginseng-Based Steroid Rg1.” Jan. 2015.10(1); https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0116387
      80. Wu, J., Saovieng, S., Cheng, I.-S., et. al. Journal of Ginseng Research. “Ginsenoside Rg1 Supplementation Clears Senescence-Associated Β-Galactosidase in Exercising Human Skeletal Muscle.”; https://www.sciencedirect.com/science/article/pii/S1226845318301131
      81. Korivi, M., Hou, C.-W., et. al. Evidence-Based Complementary and Alternative Medicine. “Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats.”, 2012. https://www.hindawi.com/journals/ecam/2012/932165/
      82. Yu, S.-H., Huang, H.-Y., et. al.Journal of the International Society of Sports Nutrition. “Oral Rg1 Supplementation Strengthens Antioxidant Defense System Against Exercise-Induced Oxidative Stress in Rat Skeletal Muscles.”, May 2012; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-23
      83. Wu, J., Saovieng, S., et. al. (2019). Journal of Functional Foods. “Satellite Cells Depletion in Exercising Human Skeletal Muscle Is Restored by Ginseng Component Rg1 Supplementation.” 2019; https://www.sciencedirect.com/science/article/abs/pii/S1756464619302208
      84. Roberto, Mike, and Luther, CJ; “Astragalosides and Ginsenosides: Differentiating NuLiv Science’s Ingredients”; The PricePlow Blog; June 14, 2021; Astragalosides and Ginsenosides: Differentiating NuLiv Science’s Ingredients
      85. Lou, H. C., et al. “Increased Vigilance and Dopamine Synthesis by Large Doses of Tyrosine or Phenylalanine Restriction in Phenylketonuria.” Acta Paediatrica Scandinavica, vol. 76, no. 4, 1 July 1987, pp. 560–565, doi:10.1111/j.1651-2227.1987.tb10521.x; https://pubmed.ncbi.nlm.nih.gov/2442957/
      86. Smith, Matthew D, and Christopher V Maani. “Norepinephrine.” Nih.gov, StatPearls Publishing, 23 July 2019. https://www.ncbi.nlm.nih.gov/books/NBK537259/
      87. Hase, Adrian, et al. “Behavioral and Cognitive Effects of Tyrosine Intake in Healthy Human Adults.” Pharmacology, Biochemistry, and Behavior, vol. 133, June 2015, pp. 1–6, doi:10.1016/j.pbb.2015.03.008; https://pubmed.ncbi.nlm.nih.gov/25797188/
      88. Ans, Armghan H, et al. “Neurohormonal Regulation of Appetite and Its Relationship with Stress: A Mini Literature Review.” Cureus, 23 July 2018, 10.7759/cureus.3032. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150743/
      89. Mullur, Rashmi et al. “Thyroid hormone regulation of metabolism.” Physiological reviews vol. 94,2 (2014): 355-82. doi:10.1152/physrev.00030.2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044302/
      90. Rousset, Bernard. “Chapter 2 Thyroid Hormone Synthesis And Secretion.” Endotext. U.S. National Library of Medicine, 2 Sept. 2015; https://www.ncbi.nlm.nih.gov/books/NBK285550/
      91. Rousset, Bernard, et al. “Chapter 2 Thyroid Hormone Synthesis and Secretion.” Nih.gov, MDText.com, Inc., 2 Sept. 2015. https://www.ncbi.nlm.nih.gov/books/NBK285550/
      92. Mullur, Rashmi, et al. “Thyroid Hormone Regulation of Metabolism.” Physiological Reviews, vol. 94, no. 2, Apr. 2014, pp. 355–382, 10.1152/physrev.00030.2013. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044302/
      93. Fontana, Luigi et al. “Effect of long-term calorie restriction with adequate protein and micronutrients on thyroid hormones.” The Journal of clinical endocrinology and metabolism vol. 91,8 (2006): 3232-5. doi:10.1210/jc.2006-0328 https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2006-0328?login=false
      94. Attipoe, Selasi, et al. “Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature.” Military Medicine, vol. 180, no. 7, July 2015, pp. 754–765, 10.7205/milmed-d-14-00594; https://academic.oup.com/milmed/article/180/7/754/4160625
      95. Pomeroy, Diane E., et al. “A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel.” Nutrients, vol. 12, no. 2, 20 Feb. 2020, p. 545, 10.3390/nu12020545; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071459/
      96. Sanders LM, Zeisel SH; “Choline: Dietary Requirements and Role in Brain Development;” Nutrition today; 2007;42(4):181-186; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518394/
      97. Purves D, Augustine GJ, Fitzpatrick D, et al.; “Neuroscience;” 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Acetylcholine; https://www.ncbi.nlm.nih.gov/books/NBK11143/
      98. Zeisel, Steven H. “Choline: Critical Role during Fetal Development and Dietary Requirements in Adults.” Annual Review of Nutrition, vol. 26, 2006, pp. 229–250, 10.1146/annurev.nutr.26.061505.111156; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441939/
      99. Kuksis, A., and S. Mookerjea. “Choline.” Nutrition Reviews, vol. 36, no. 7, 27 Apr. 2009, pp. 201–207, 10.1111/j.1753-4887.1978.tb07359.x; https://academic.oup.com/nutritionreviews/article-abstract/36/7/201/1831331
      100. Zeisel, S H, and J K Blusztajn. “Choline and Human Nutrition.” Annual Review of Nutrition, vol. 14, no. 1, July 1994, pp. 269–296, 10.1146/annurev.nu.14.070194.001413; https://pubmed.ncbi.nlm.nih.gov/7946521/
      101. da Costa, Kerry-Ann, et al. “Effects of Prolonged (1 Year) Choline Deficiency and Subsequent Re-Feeding of Choline on 1,2-Sn-Diradylglycerol, Fatty Acids and Protein Kinase c in Rat Liver.” Carcinogenesis, vol. 16, no. 2, 1995, pp. 327–334, 10.1093/carcin/16.2.327; https://academic.oup.com/carcin/article-abstract/16/2/327/348681
      102. Dodson WL, Sachan DS. Choline supplementation reduces urinary carnitine excretion in humans. Am J Clin Nutr. 1996;63(6):904-910. https://www.ncbi.nlm.nih.gov/pubmed/8644685
      103. PubChem. “Theobromine.” Nih.gov, PubChem, 2019, https://www.pubchem.ncbi.nlm.nih.gov/compound/Theobromine
      104. Yoneda, Mitsugu et al. “Theobromine up-regulates cerebral brain-derived neurotrophic factor and facilitates motor learning in mice.” The Journal of nutritional biochemistry vol. 39 (2017): 110-116. doi:10.1016/j.jnutbio.2016.10.002 https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(16)30105-X
      105. Valsecchi, Federica et al. “cAMP and mitochondria.” Physiology (Bethesda, Md.) vol. 28,3 (2013): 199-209. doi:10.1152/physiol.00004.2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870303/
      106. ‌Aslam, Muhammad, and Yury Ladilov. “Emerging Role of cAMP/AMPK Signaling.” Cells vol. 11,2 308. 17 Jan. 2022, doi:10.3390/cells11020308; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774420/
      107. Coleman, William F. “Chocolate: Theobromine and Caffeine.” Journal of Chemical Education, vol. 81, no. 8, Aug. 2004, p. 1232 https://pubs.acs.org/doi/abs/10.1021/ed081p1232
      108. Mitchell, E S et al. “Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure.” Physiology & behavior vol. 104,5 (2011): 816-22. doi:10.1016/j.physbeh.2011.07.027 https://www.sciencedirect.com/science/article/abs/pii/S0031938411003799
      109. ‌Barokah, Liberty, et al. “Protective Effect of Theobroma Cacao on Nitric Oxide and Endothelin-1 Level in Endothelial Cells Induced by Plasma from Preeclamptic Patients: In Silico and in Vitro Studies.” European Journal of Integrative Medicine, vol. 8, no. 1, 1 Feb. 2016, pp. 73–78; 10.1016/j.eujim.2015.11.023; https://www.sciencedirect.com/science/article/abs/pii/S1876382015300639
      110. Baggott, Matthew J et al. “Psychopharmacology of theobromine in healthy volunteers.” Psychopharmacology vol. 228,1 (2013): 109-18. doi:10.1007/s00213-013-3021-0; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672386/
      111. Tang, X. C., et al. “Effect of Huperzine A, a New Cholinesterase Inhibitor, on the Central Cholinergic System of the Rat.” Journal of Neuroscience Research, vol. 24, no. 2, 1 Oct. 1989, pp. 276–285, 10.1002/jnr.490240220. https://pubmed.ncbi.nlm.nih.gov/2585551/
      112. Damar, U., et al. “Huperzine a as a Neuroprotective and Antiepileptic Drug: A Review of Preclinical Research.” Expert Review of Neurotherapeutics, vol. 16, no. 6, 1 June 2016, pp. 671–680, 10.1080/14737175.2016.1175303. https://pubmed.ncbi.nlm.nih.gov/27086593/
      113. [vi] Gao X., Tang X.C. “Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.”Journal of Neuroscience Research. 2006 May 1;83(6):1048-57; https://pubmed.ncbi.nlm.nih.gov/16493671/
      114. Ma, Tuo, et al. “Huperzine a Promotes Hippocampal Neurogenesis in Vitro and in Vivo.” Brain Research, vol. 1506, 19 Apr. 2013, pp. 35–43, 10.1016/j.brainres.2013.02.026; https://pubmed.ncbi.nlm.nih.gov/23454433/
      115. Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170. https://pubmed.ncbi.nlm.nih.gov/1356551/
      116. Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance.”; J Int Soc Sports Nutr 7, 5 (2010); https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-5
      117. Diepvens, K et al; “Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea;” American Journal of Physiology; 2007; https://journals.physiology.org/doi/full/10.1152/ajpregu.00832.2005
      118. Lin, Hang-Ching, et al. “Method for Regulating Nutrient Absorption with Ginsenosides”; United States Patent and Trademark Office; Patent US20090181904A1; July 16, 2009; https://patents.google.com/patent/US20090181904A1/
      119. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US20120196816A1; August 2, 2012; https://patents.google.com/patent/US20120196816A1/
      120. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US20120196817A1; August 2, 2012; https://patents.google.com/patent/US20120196817A1/
      121. Lin, Hang-Ching, et al. “Method for Enhancing Nutrient Absorption with Astragalosides”; United States Patent and Trademark Office; Patent US8197860B2; June 12, 2012; https://patents.google.com/patent/US8197860B2/en
      122. Lin, Hang-Ching, et al. “Compound for enhancing nutrients uptake”; Taiwan Intellectual Property Office; Patent TWI271195B; 28-Dec 2004; https://patents.google.com/patent/TWI271195B/en
      123. Majeed, M, et al; “Use of piperine to increase the bioavailability of nutritional compounds”; United States Patent US5536506A; 24-Feb 1995; https://patents.google.com/patent/US5536506A/en
      124. Majeed, M, et al; “Use of piperine as a bioavailability enhancer”; United States Patent US5744161A; 30-Oct 1995; https://patents.google.com/patent/US5744161A/en
      125. Majeed, M, et al; “Use of piperine as a bioavailability enhancer”; United States Patent US5972382A; 12-Jan 1998; https://patents.google.com/patent/US5972382A/en
      126. Majeed, M; “Process for making high purity piperine for nutritional use”; United States Patent US6054585A; 23-Dec 1998; https://patents.google.com/patent/US6054585A/en
      127. Haq, Iahtisham-Ul et al. “Piperine: A review of its biological effects.” Phytotherapy research : PTR vol. 35,2 (2021): 680-700. doi:10.1002/ptr.6855 https://onlinelibrary.wiley.com/doi/10.1002/ptr.6855
      128. Maeda A, Shirao T, Shirasaya D, Yoshioka Y, Yamashita Y, Akagawa M, Ashida H. Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle. Mol Nutr Food Res. 2018 Jun;62(11):e1800086. doi: 10.1002/mnfr.201800086; https://pubmed.ncbi.nlm.nih.gov/29683271/
      129. Choi S, Choi Y, Choi Y, Kim S, Jang J, Park T. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice. Food Chem. 2013 Dec 15;141(4):3627-35. doi: 10.1016/j.foodchem.2013.06.028; https://www.sciencedirect.com/science/article/abs/pii/S0308814613008030
      130. Mittal R, Gupta RL. In vitro antioxidant activity of piperine. Methods Find Exp Clin Pharmacol. 2000 Jun;22(5):271-4. doi: 10.1358/mf.2000.22.5.796644; https://pubmed.ncbi.nlm.nih.gov/11031726/
      131. Adams, J; “Absorption of cyanocobalamin, coenzyme B 12 , methylcobalamin, and hydroxocobalamin at different dose levels”; Scand J Gastroenterol. 1971;6(3):249-52; http://www.ncbi.nlm.nih.gov/pubmed/5560708

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