Primeval Labs Ape Sh*t MAX PUMP: Unleash the Inner Primate Pump

Published on June 8, 2022 by Mike Roberto and Nick Andrews | No Comments

Here we go, primates! If you thought Primeval Labs was done with their insane Ape Sh*t series of supplements, then think again. Today, they’re taking things to the MAX.

The brand that brought you EAA Max isn’t done maxing out just yet – they’ve got a stimulant-free nitric oxide booster for you to take solo or stack with any of their other stim-based pre-workouts linked above:

Primeval Labs Ape Sh*t MAX Pump

Look at this label! Primeval Labs Ape Sh*t MAX Pump is going all-in on stim-free pumps, focus, and strength!

Ape Sh*t MAX PUMP: Taking patented pumps to the MAX

Primeval Labs Ape Sh*t MAX PUMP is what it says it is – an extreme pump supplement with two patented pump supplements, led by a clinically-tested 1.5 gram dose of Nutrition21’s Nitrosigine, paired with the new 3D Pump Breakthrough.

It’s not just about Nitrosigine’s epic nitric oxide production, though — inside, we also have the cell volumization and hydration trifecta from glycerol, betaine, and taurine — three ingredients we love to see together.

That’s not all, though – there’s some focus boosters in here as well, including large doses of tyrosine and alpha-GPC. It was released alongside the stim-based Primeval Labs Ape Sh*t MAX, which you can stack in to get the energy level you desire!

Get ready for a stim-free pump supplement that has the entire fitness world on watch. But first, let’s check availability and our Primeval Labs news alerts, because if there’s Ape Sh*t MAX PUMP here… you can rest assured that there may be an Ape Sh*t MAX coming too:

Primeval Labs Ape Sh*t MAX Pump – Deals and Price Drop Alerts

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Ape Sh*t MAX PUMP Ingredients

Ape Shit MAX PUMP can be taken in single scoop doses, but is designed to be double-scooped if you really want to get after it and are chasing clinical doses. For most people, the choice of dose will depend on the stack – if you’re already taking a pre-workout, you may only need one scoop… but if you’re using this solo, two scoops is likely the way to go – especially to get that clinical 1.5 grams of Nitrosigine we love!

In a 2 scoop serving of Ape Sh*t MAX PUMP, you get the following:

  • 3D Pump Breakthrough [L-Citrulline (Vegan Fermented, Glycerol, Amla (Emblica officinalis) (fruit) extract] – 6,000 mg

    Primeval Labs Ape Sh*t Max Pump Label

    With one look at the Primeval Labs Ape Sh*t Max Pump label, and you basically know it’s going to be a good one

    3D Pump Breakthrough is a patented performance blend consisting of L-Citrulline, glycerol, and Amla fruit extract.

    Because it’s capable of increasing nitric oxide production (L-citrulline), blood flow (amla), and cellular hydration (glycerol) all at the same time, a sizable dose of 3D Pump Breakthrough can definitely give you a noticeable boost in your athletic performance and your pumps.

    Pilot Study

    The patent for 3D Pump Breakthrough cites a pilot study that reveals a bit about how this ingredient works and what makes it special.[1]

    Scientists conducted this study in resistance-trained men averaging 28 years old. The sample size was relatively small, but the study used a repeating design that enabled the participants to serve as their own controls.[1] They did the exact same workout on four different days, taking one of four different treatments:

    • Water (the placebo control)
    • 1.5 grams of glycerol
    • 150 milligrams of amla fruit extract
    • 1.35 grams of glycerol and 150 milligrams of amla fruit extract
    Primeval Labs Ape Sh*t Pumps

    Ape Sh*t Pumps is good, but this takes things to the MAX

    The study workout consisted of leg exercises: 3 sets of leg extensions and weighted goblet squats, for 10-12 reps in each set, with 1 minute of rest between sets. The participants also rested for 2 minutes between exercises.

    All the training sessions were followed up by DEXA scans that researchers used to measure the thigh circumference of each subject, which was taken as an index of cellular hydration.

    Although increases in leg size and lean body mass were observed following each treatment, the combination of glycerol and amla did better than the other three. This treatment increased the subjects’ thigh circumference by 2.21 centimeters, and their lean body mass by 693.1 grams. Compare this to the placebo treatment, which increased thigh circumference by only 1.12 cm and lean body mass by 30.4 grams.[1]

    One important thing to note about this study was that the group who got amla only did better than the group that got glycerol only. Given that glycerol is a well-established mainstay ingredient for cellular hydration, that says a lot about the efficacy of amla. So let’s start there in our breakdown:

    • What is Amla and how does it work?

      Primeval Labs Logo

      Get ready to get Primeval today

      Amla, whose scientific name is Phyllanthus emblica, has been known to Ayurvedic medicine for thousands of years.[2] It was traditionally used to promote good circulation and enhance cardiovascular health, and as usual, recent scientific research has corroborated the ancient wisdom. Evidence is mounting that the particular blend of antioxidants in amla can significantly improve endothelial function while reducing platelet aggregation.[3]

      There isn’t a whole lot of research on amla’s potential benefits for athletic performance, but generally speaking, supplements that benefit circulation and overall cardiovascular function tend to be good in pre workout supplements. That seems to be true in amla’s case!

      Low molecular weight tannins and cellular energy

      Any potent botanical extract ingredient is standardized for a particular bioactive constituent in order to ensure a consistent level of efficacy from batch to batch. When it comes to 3D Pump’s amla extract, the standardization is for at least 68% low molecular weight tannins (LMWTs) by weight.

      Primeval Labs Ape Sh*t Max Pump

      MAX. PUMP.

      This category includes the tannins emblicanin-A, emblicanin-B, punigluconin, and pedunculagin.[4] When ingested, these tannins are metabolized into urolithins A, B, C and D,[5] which have documented benefits for mitochondrial function.[6]

      Because we harp on this so much, regular readers of the PricePlow blog will already know that the ability of one’s mitochondria to produce adenosine triphosphate (ATP), the basic unit of cellular energy, is closely tied to physical performance and general health.[7,8] Additionally, urolithin B seems to have some anabolic effects.[9]

      Amla extracts as a whole may even have nootropic properties,[10] sweetening the pot even more.

    • L-Citrulline

      The amino acid citrulline is a precursor to arginine, another amino that in turn is a precursor to nitric oxide (NO). Supplementing with citrulline has consistently been shown to increase the body’s production of NO,[11] owing to the ability of its metabolite arginine to upregulate nitric oxide synthase,[12] the enzyme that creates NO for endothelial cells.

      Arginine Biosynthesis System

      The Arginine Biosynthesis System. Image courtesy Wikimedia, with our red edits demonstrating the arginine citrulline cycle at the top-right

      Naively, you might think that supplementing with arginine itself would be a more efficient strategy for increasing NO, but for reasons that are beyond the scope of this section, it turns out that citrulline is better than arginine.[13-15]

      If you’re really curious about arginine vs. citrulline, keep reading – we will go into detail in the Nitrosigine section below.

      Increased NO production is great on a number of levels, because NO triggers vasodilation, a phenomenon where blood vessels expand in diameter to permit more blood flow. When it comes to athletics, better circulation means better performance[16,17] and faster recovery.[18]

      Citrulline-specific studies have consistently found that supplementation with citrulline confers the benefits we’d expect from higher levels of NO.[19-21] A 2020 meta-analysis of 13 different studies found that citrulline can reduce perceived exertion during exercise and reduce soreness following exercise.[22]

      Arginine Citrulline Cycle

      The Arginine Citrulline Cycle. Image courtesy Wikimedia commons (red edits are ours)

      One thing to note about the citrulline meta-analysis is that the dose typically used in the studies under review was 8 grams of citrulline malate,[22] so if you want to maximize the effectiveness of the citrulline in MAX PUMP, you should probably opt for the 2 scoop serving size.

    • Glycerol and cellular hydration

      Drink up – the osmolyte glycerol can increase the body’s total water volume,[23] leading to a state called hyperhydration[24] wherein improved cellular hydration can increase an individual’s athletic endurance and resistance to heat stress.[25-27]

      The catch is that in order for glycerol to move water into your cells, you have to drink lots of water along with the glycerol. Otherwise there won’t be any water for glycerol to move.

      If you want to learn more about glycerol and how it works, check out our long-form article Glycerol: The Ultimate Guide for Hydration, Heat Protection, and Pumps.[28]

    New Insights: In 2023, a study delving into the effects of 3DPump has been published. Read about it in our article titled 3DPump Breakthrough STUDY: 6g Takes on 8g L-Citrulline!.

  • Beta Alanine – 3200 mg

    The non-essential amino acid beta-alanine is a precursor to carnosine,[29] a dipeptide molecule that can buffer lactic acid within muscle tissue, thus increasing the endurance of the muscle. The reason this works is that the accumulation of lactic acid in muscles is what produces physical fatigue and, eventually, muscular failure, so anything that prevents this action of lactic acid will have the effect of reducing fatigue.

    Beta Alanine Benefits

    We’re interested in section (B) here, where beta alanine alone shows great results compared to placebo.[30]

    The research literature on this topic is robust, with two large meta-analyses from 2012 and 2016 both concluding that for any form of exercise between 30 seconds and 10 minutes in duration, beta-alanine does indeed boost exercise capacity (the total volume of work done during an exercise session) in athletes who take it.[30,31]

    This effect has earned beta-alanine the designation of ergogenic aid, defined as any substance that increases an athlete’s capacity for physical work.

    Don’t worry – beta-alanine tingles are benign

    Beta-alanine can sometimes cause a tingling sensation in those who take it, and although this may feel alarming if you’ve never experienced it before, it’s harmless. A 2019 study concluded that beta-alanine “does not adversely affect those consuming it.”[32]

  • Betaine anhydrous – 2500 mg

    Betaine, sometimes referred to as trimethylglycine (TMG), is another ergogenic aid like beta-alanine.

    However, betaine’s ergogenic effects are exerted through a different mechanism: Betaine is a methyl donor. This means that it carries methyl groups to places in the body where they are required for certain metabolic processes.

    For example, betaine can reduce homocysteine levels,[33] which is important for optimal cardiovascular health and function.

    Betaine Benefits

    The placebo effect was definitely strong with this group. But… the real gains obliterated placebo in due time![34] This is just one of many ingredients here that has these types of effects

    Betaine is also an osmolyte, like glycerol, and helps fill your cells with water and nutrients. This optimizes cellular function and protects cells from heat stress,[34-36] which is an important consideration for anyone doing intense exercise.

    The pile of research corroborating betaine’s performance benefits is about a mile high,[37-42] but two seminal studies from 2013 and 2014 found that a 2.5 gram daily dose of betaine, taken for six weeks, is capable of increasing lean body mass by 5.3 pounds and decreasing fat mass by 6.4 pounds within that time frame.[34,43] That’s a pretty incredible 3% body fat reduction in less than two months.

    Note that the clinically-verified 2.5 gram dose of betaine is what you get in 2 scoops of MAX PUMP, so if you want to ensure these benefits, be sure to double-down on that scooper.

  • L-Tyrosine – 2000 mg

    Primeval Labs Ape Sh*t Alpha

    Need some stims to stack in? Meet the Apex Predator Pre-Workout: Primeval Labs Ape Sh*t Alpha

    Just because it’s stimulant-free doesn’t mean it’s gotta be focus-free. Primeval does what most brands don’t do in their pump supplements here – adds feel-good tyrosine.

    The essential amino acid l-tyrosine is an important precursor for dopamine, adrenaline, and other neurotransmitters that increase focus and alertness.[44] Raising our levels of these neurotransmitters by supplementing with tyrosine can help jump start our sympathetic nervous system, which is responsible for instigating the famous “fight or flight” response that helps us perform physically.

    Tyrosine can help attenuate the problems caused by sleep deprivation, and studies have consistently shown that sleep-deprived individuals who supplement with tyrosine perform better on cognitive tests.[45,46]

  • L-Taurine – 2000 mg

    Here we have yet another osmolyte in the form of taurine, a conditionally essential amino acid. Whereas nonessential aminos are those our body can synthesize endogenously and essential aminos are those it can’t, the conditionally essential aminos are produced by our bodies in quantities too limited to cover all our metabolic requirements, particularly in times of illness or stress.

    Like the other osmolytes we’ve discussed, taurine can increase athletic endurance.[47] It also reduces oxidative stress, facilitates muscle contractions by improving cellular calcium signaling, and helps metabolize fat.[47-50]

    One 2018 meta-analysis found that as little as 1 gram of taurine (the dose contained in 1 scoop of MAX PUMP) is able to immediately increase athletic endurance.[47]

    Taurine also has some nootropic effects[49] and increases nitric oxide production,[50] so it’s easy to see why taurine is increasingly common in pre workout supplement formulas.

    Taurine Endurance

    Taurine’s effect on endurance, with success in doses anywhere from 1 gram to 6 grams.[47]

    If you opt for the 2 scoop serving of MAX PUMP, you’ll get 2 grams of taurine, which the research literature indicates may increase your all-important mitochondrial function.[51]

    Rounding out the cell hydration trifecta

    We love supplements with the hydration trifecta:

    • Glycerol
    • Betaine
    • Taurine

    Ape Sh*t MAX Pump brings all three!

    Now it’s time to get back to nitric oxide production.

  • Inositol-stabilized Arginine Silicate (as Nitrosigine) – 1500 mg

    Nitrosigine is a patented chemical compound consisting of arginine, inositol, and potassium silicate.[52] Known as inositol-stabilized arginine silicate, it’s often abbreviated as ASI in scientific research, but we call it Nitrosigine, its trademarked name.

    Nitrosigine 2022 Cognitive Study Infographic

    A nitric oxide booster that improves cognition?! Yes – Nutrition21 passed around this helpful infographic after the Nitrosigine cognition study on healthy young adults was published.[53]

    Remember what we said in the 3D Pump Breakthrough section about citrulline being better at increasing nitric oxide (NO) levels than standard L-arginine?

    The reason is that citrulline is more bioavailable than plain L-arginine, and takes an “end-around” way of generating NO in the kidneys. Arginine is nitric oxide’s precursor, but when pure arginine is taken alone, the enzyme arginase breaks down most of it in the stomach before it can be absorbed into the bloodstream where it could actually increase NO production.[54] This is called the first pass effect, and it was the problem that Nitrosigine was designed to solve.

    As it turns out, if you bind arginine to potassium silicate and complex it with inositol, the combination of molecules will buffer the arginine, thus sparing it from the first pass effect[55] and allowing much more of the ingested arginine to ultimately enter the bloodstream – in other words, increasing the bioavailability of arginine.[55]

    Nitrosigine is both fast-acting and long-lasting, raising NO levels as soon as 30 minutes after being taken and having this effect for up to 6 hours.[56,57]

    Besides the usual benefits of NO production, increased athletic performance[58,59] and faster recovery,[59,60] Nitrosigine has also been shown to have some nootropic effects.[53] Specifically, it can prevent the temporary bit significant cognitive impairment that typically follows intense exercise,[61] speed up task switching,[62] and increase energy levels.[56]

    Long story short? Better nitric oxide production (leading to great pumps), and less “bonking” after training.

    Each year, we’re seeing more research come out on Nitrosigine, which solidifies its position as a de-facto top-tier nitric oxide boosting ingredient that we’d expect in any supplement with the words “MAX PUMP” in its name. Alone, it’s phenomenal – combined with everything else Primeval Labs is adding here, it’s going to be out of this world.

    Nitrosigine Research

    Nutrition 21’s claims have stood the test of time with Nitrosigine. Image courtesy Nutrition21

    If you’re interested in learning more about Nitrosigine and how it works, please read our full-length article Nitrosigine: The Nitric Oxide Booster That Enhances Brain Function. Inside, we also cover some of the recent cognitive-supporting research, linking to detailed articles on those studies.

    Given Nutrition21’s stance as an industry-leading research company, we expect more to come with time, too.

  • Agmatine Sulfate – 1500 mg

    So far we have citrulline and Nitrosigine, both of which increase nitric oxide (NO) production by increasing arginine blood levels.

    The arginine metabolite agmatine sulfate attacks the NO problem from the other end of the arginine mechanism – instead of increasing the amount of arginine going into our blood, it inhibits arginase, the enzyme that degrades arginine.[63] In other words, it preserves the arginine we already have, which means it will synergize nicely with both citrulline and Nitrosigine.

    However, agmatine has also been shown to stimulate NO production directly by upregulating nitric oxide synthase.[64]

    Agmatine also functions as a neurotransmitter with positive effects on mood.[65] We like seeing mood boosters in pre-workout formulas because after all, motivation is an important factor in completing a workout.

  • Alpha-Glyceryl Phosphoryl Choline 50% (AlphaSize) – 600 mg

    Focus and strength are added factors in getting killer workouts done, and this dose of alpha-GPC can aid in both. As a highly bioavailable form of choline, alpha-GPC can help increase your levels of acetylcholine, which we often call the “learning neurotransmitter” owing to its crucial role in learning, memory consolidation, and many other cognitive processes.

    The research literature indicates that supplemental choline can significantly improve both cognitive and physical performance, and that choline deficiency can cause serious cognitive dysfunction.[66,67]

    Choline also helps maintain the integrity of cell membranes,[68] a task of crucial importance for cellular function and health.

    600 milligrams: demonstrated strength gains!

    Alpha GPC Strength

    Alpha GPC isn’t just good for enhancing brain function, it can also deliver some big strength gains (when dosed at 600mg or greater).[69]

    A small random, double-blinded study published in 2008 showed that 600 milligrams of AlphaSize alpha-GPC led to increased strength and power in bench press.[70] A follow-up study published in 2016 showed that six days of 600 milligrams of alpha-GPC led to increased force in leg strength (via mid-thigh pull),[69] giving us research on both upper and lower body strength.

    Our take is that the success of this ingredient as a strength-boosting agent will come down to choline status in one’s diet. If you’re not “slonking” eggs on the regular, a full 600 milligram clinical dose of alpha-GPC is a great call.

    We like seeing AlphaSize being used instead of generic alpha-GPC because of its high purity compared to generic forms.

  • Grape Seed Extract (95% Proanthocyanidins) (Vitis vinifera) – 300 mg

    Primeval Labs Intracell 7

    Primeval Labs Intracell 7 is back in 2022, and the carb-loaded performance-based intra-workout supplement has a new Gummy Bear flavor with it!

    Grape seed extract (GSE) contains high amounts of proanthocyanidins, a special class of antioxidant with powerful benefits for liver health.

    In mice, proanthocyanidins were able to protect the liver from being damaged by a known hepatotoxin by suppressing an enzyme that causes liver steatosis, also known as fatty liver.[71] The mice who took proanthocyanidins didn’t get steatosis, unlike mice who got the placebo.[71]

    Another study found that proanthocyanidins can upregulate nicotinamide adenine dinucleotide (NAD+) in rats,[72] which is a pretty big deal since NAD+ improves mitochondrial function by upregulating a pro-longevity gene called sirtuin 1.[73]

    Proanthocyanidins also seem to upregulate glutathione (GSH) the most powerful antioxidant produced by the human body.[74]

  • Ancient Peat; Apple Extract (ElevATP) – 150 mg

    elevATP Research

    Individual Changes in Total Strength. The trend is your friend!

    ElevATP is a patented extract blend from peat moss and apples. Early studies show that ElevATP can increase ATP production,[75] which, as we’ve discussed already, is pretty awesome for health and performance on a number of levels.

    The million-dollar question, as always, is whether this extra ATP has practical benefits, and so far the answer seems to be yes. In a 2016 study, researchers found that 150 milligrams of ElevATP, taken daily for eight weeks, significantly increased study participants’ one rep max for squats and deadlifts compared to the placebo control.[76] The ElevATP group also had increases in jump velocity and power.[76]

    Once again – note that to get 150 milligrams of ElevATP, you need to take 2 scoops of MAX PUMP.

  • Green Coffee Bean Extract, Green Tea Extract, Turmeric Extract, Tart Cherry, Blueberry, Broccoli, Kale (S7) – 100 mg

    Primeval Labs Untamed Apeshit RTD Sunrise Splash

    Forget the days of boring RTD flavors like grape and fruit punch – Primeval Labs really knocked the ready-to-drink pre workout flavors out with Ape Sh*t Untamed RTD!

    This proprietary blend of seven different botanical extracts is 3% curcumin, 30% catechins, and 60% polyphenols by weight.

    There’s a ton to say about each of these ingredients individually, but when it comes to the important of S7 for the MAX PUMP formula, which seems to prioritize boosting nitric oxide (NO) production, we should note that S7 has been shown to increase NO bioavailability by up to 230%.[77]

  • Black Pepper Extract (Piper nigrum) (fruit) (Bioperine) – 10 mg

    BioPerine is a bioavailability enhancer, meaning that it can increase the absorption of whatever you take it with.[78] It does this by inhibiting certain stomach enzymes that break down a lot of what we ingest before it can be absorbed into the bloodstream.

    In other words, BioPerine is here to make sure you get the most bang for your buck.

Flavors Available

For those of you who don’t know, Primeval Labs are known as the flavor kings. They’re one of the first companies to make EAAs taste delicious with EAA Max, and with no stimulants to deal with, we’re nearly certain Ape Sh*t MAX Pump will be top-notch as well:

    Conclusion: The Ape Sh*t series steps it up even further

    We were already excited about the entire line of Ape Sh*t supplements from Primeval Labs — let’s go over the entire pre-workout platform:

    VasoGorge Get Ready For Pre-Workout Pumps

    Nitrogisine, the lynchpin ingredient of VasoGorge, is one of our favorite NO boosters. If you don’t want to do two scoops of Ape Sh*t MAX Pump, you can sub in a touch of VasoGorge too

    Additionally, VasoGorge is a capsule-based method to get Nitrosigine in, so you have many ways to boost pumps — and no excuses not to! Finally, this can all be stacked with Ape Sh*t Test, which is the (currently) only non-pre-workout in the series.

    If you couldn’t tell, Primeval Labs is serious about this line, and we’re not sure if they’ll ever be done supporting your apesh*t tendencies in the gym. Biggest question is what stack combination you’ll use to achieve total alpha ape supremacy!

    Primeval Labs Ape Sh*t MAX Pump – Deals and Price Drop Alerts

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    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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    References

    1. Ziegenfuss, T, et al; “Compositions and methods for increase in muscle volume”; United States Patent and Trademark Office; Patent #US10993978B1; May 4, 2021; https://patents.google.com/patent/US10993978B1/en
    2. Mirunalini, S., and M. Krishnaveni. “Therapeutic Potential of Phyllanthus Emblica (Amla): The Ayurvedic Wonder.” Journal of Basic and Clinical Physiology and Pharmacology, vol. 21, no. 1, Jan. 2010, 10.1515/jbcpp.2010.21.1.93; https://pubmed.ncbi.nlm.nih.gov/20506691/
    3. Khanna, Savita, et al. “Supplementation of a Standardized Extract from Phyllanthus Emblica Improves Cardiovascular Risk Factors and Platelet Aggregation in Overweight/Class-1 Obese Adults.” Journal of Medicinal Food, vol. 18, no. 4, Apr. 2015, pp. 415–420, 10.1089/jmf.2014.0178; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4390209/
    4. Usharani, Pingali, et al. “Effects of Phyllanthus Emblica Extract on Endothelial Dysfunction and Biomarkers of Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized, Double-Blind, Controlled Study.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, vol. 6, 26 July 2013, pp. 275–284, 10.2147/DMSO.S46341; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3735284/
    5. Kapoor, Mahendra Parkash, et al. “Clinical Evaluation of Emblica Officinalis Gatertn (Amla) in Healthy Human Subjects: Health Benefits and Safety Results from a Randomized, Double-Blind, Crossover Placebo-Controlled Study.” Contemporary Clinical Trials Communications, vol. 17, Mar. 2020, p. 100499, 10.1016/j.conctc.2019.100499; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6926135/
    6. Larrosa, Mar, et al. “Ellagitannins, Ellagic Acid and Vascular Health.” Molecular Aspects of Medicine, vol. 31, no. 6, Dec. 2010, pp. 513–539, 10.1016/j.mam.2010.09.005; https://pubmed.ncbi.nlm.nih.gov/20837052/
    7. Hill, Shauna, and Holly Van Remmen. “Mitochondrial Stress Signaling in Longevity: A New Role for Mitochondrial Function in Aging.” Redox Biology, vol. 2, 2014, pp. 936–944, 10.1016/j.redox.2014.07.005. Accessed 20 Oct. 2021; https://www.sciencedirect.com/science/article/pii/S2213231714000883
    8. “New Research on the Muscles of Elite Athletes: When Quality Is Better than Quantity.” ScienceDaily, 2016; https://www.sciencedaily.com/releases/2016/11/161102132208.htm
    9. Francaux, Marc, and Louise Deldicque. “Using Polyphenol Derivatives to Prevent Muscle Wasting.” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 21, no. 3, 1 May 2018, pp. 159–163, 10.1097/MCO.0000000000000455; https://pubmed.ncbi.nlm.nih.gov/29356695/
    10. Uddin, Md. Sahab, et al. “Exploring the Effect of Phyllanthus Emblica L. On Cognitive Performance, Brain Antioxidant Markers and Acetylcholinesterase Activity in Rats: Promising Natural Gift for the Mitigation of Alzheimer’s Disease.” Annals of Neurosciences, vol. 23, no. 4, 2016, pp. 218–229, 10.1159/000449482; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075744/
    11. Sureda, Antoni, et al. “L-Citrulline-Malate Influence over Branched Chain Amino Acid Utilization during Exercise.” European Journal of Applied Physiology, vol. 110, no. 2, 25 May 2010, pp. 341–351, 10.1007/s00421-010-1509-4; https://pubmed.ncbi.nlm.nih.gov/20499249/
    12. Bailey, SJ et al.; “l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.”; Journal of Applied Physiology; 119(4) pp. 385-395; 2015; https://journals.physiology.org/doi/full/10.1152/japplphysiol.00192.2014
    13. Schwedhelm, Edzard et al.; “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.”; British journal of clinical pharmacology vol. 65,1 (2008): 51-9.; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291275/
    14. Castillo, L, et al. “Splanchnic Metabolism of Dietary Arginine in Relation to Nitric Oxide Synthesis in Normal Adult Man.” Proceedings of the National Academy of Sciences of the United States of America, vol. 90, no. 1, 1 Jan. 1993, pp. 193–197; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45626/
    15. Wu, Guoyao. “Intestinal Mucosal Amino Acid Catabolism.” The Journal of Nutrition, vol. 128, no. 8, 1 Aug. 1998, pp. 1249–1252, 10.1093/jn/128.8.1249; https://academic.oup.com/jn/article/128/8/1249/4722724
    16. Suzuki, I., Sakuraba, K., Horiike, T. et al. A combination of oral l-citrulline and l-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial. Eur J Appl Physiol 119, 1075–1084; 2019; https://link.springer.com/article/10.1007/s00421-019-04097-7
    17. ‌Takashi Suzuki, Masahiko Morita, Toshio Hayashi, Ayako Kamimura, The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males, Bioscience, Biotechnology, and Biochemistry, Volume 81, Issue 2, 1 February 2017, Pages 372–375; https://academic.oup.com/bbb/article/81/2/372/5955995
    18. Oral O. Nitric oxide and its role in exercise physiology. J Sports Med Phys Fitness. 2021 Sep;61(9):1208-1211. doi: 10.23736/S0022-4707.21.11640-8; https://pubmed.ncbi.nlm.nih.gov/21094266/
    19. Giannesini B., et. al.; European Journal of Pharmacology; “Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle;” September 2011; http://www.ncbi.nlm.nih.gov/pubmed/21664351
    20. Perez-Guisado J, Jakeman PM; Journal of Strength and Conditioning; “Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness;” May 2010; http://www.ncbi.nlm.nih.gov/pubmed/20386132
    21. Hickner RC. et. al.; Medicine and Science in Sports and Exercise; “L-citrulline reduces time to exhaustion and insulin response to a graded exercise test;” 2006; http://www.ncbi.nlm.nih.gov/pubmed/16679980
    22. Rhim, Hye Chang, et al. “Effect of Citrulline on Post-Exercise Rating of Perceived Exertion, Muscle Soreness, and Blood Lactate Levels: A Systematic Review and Meta-Analysis.” Journal of Sport and Health Science, Feb. 2020, 10.1016/j.jshs.2020.02.003. https://www.sciencedirect.com/science/article/pii/S2095254620300168
    23. Patlar, Suleyman, et al. “The Effect of Glycerol Supplements on Aerobic and Anaerobic Performance of Athletes and Sedentary Subjects.” Journal of Human Kinetics, vol. 34, no. 1, 1 Oct. 2012, pp. 69–79, 10.2478/v10078-012-0065-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/
    24. Nelson, Jeff L, and Robert A Robergs. “Exploring the Potential Ergogenic Effects of Glycerol Hyperhydration.” Sports Medicine, vol. 37, no. 11, 2007, pp. 981–1000, 10.2165/00007256-200737110-00005. https://www.ncbi.nlm.nih.gov/pubmed/17953468
    25. Montner, P., et al. “Pre-Exercise Glycerol Hydration Improves Cycling Endurance Time.” International Journal of Sports Medicine, vol. 17, no. 1, 1 Jan. 1996, pp. 27–33, 10.1055/s-2007-972804. https://pubmed.ncbi.nlm.nih.gov/8775573/
    26. Patlar, Suleyman, et al. “The Effect of Glycerol Supplements on Aerobic and Anaerobic Performance of Athletes and Sedentary Subjects.” Journal of Human Kinetics, vol. 34, no. 1, 1 Oct. 2012, pp. 69–79, 10.2478/v10078-012-0065-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/
    27. Anderson, M. J., et al. “Effect of Glycerol-Induced Hyperhydration on Thermoregulation and Metabolism during Exercise in the Heat.” International Journal of Sport Nutrition, vol. 11, no. 3, 29 Sept. 2001, pp. 315–333. https://research.monash.edu/en/publications/effect-of-glycerol-induced-hyperhydration-on-thermoregulation-and
    28. Roberto, Mike; “Glycerol: The Ultimate Guide for Hydration, Heat Protection, and Pumps”; The PricePlow Blog; August 20, 2020; https://blog.priceplow.com/supplement-research/glycerol
    29. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    30. Saunders, Bryan, et al. “β-Alanine Supplementation to Improve Exercise Capacity and Performance: A Systematic Review and Meta-Analysis.” British Journal of Sports Medicine, vol. 51, no. 8, 18 Oct. 2016, pp. 658–669; https://bjsm.bmj.com/content/51/8/658.long
    31. Hobson, R M et al. “Effects of β-alanine supplementation on exercise performance: a meta-analysis.” Amino acids vol. 43,1 (2012): 25-37. doi:10.1007/s00726-011-1200-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
    32. Dolan, Eimear, et al. “A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.” Advances in Nutrition, vol. 10, no. 3, 13 Apr. 2019, pp. 452–463, 10.1093/advances/nmy115; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520041/
    33. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
    34. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    35. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4[1]:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    36. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    37. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    38. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    39. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    40. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    41. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    42. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
    43. Cholewa, Jason M., et al. “Effects of Betaine on Performance and Body Composition: A Review of Recent Findings and Potential Mechanisms.” Amino Acids, vol. 46, no. 8, 24 Apr. 2014, pp. 1785–1793, 10.1007/s00726-014-1748-5; https://pubmed.ncbi.nlm.nih.gov/24760587/
    44. Pietz J, Landwehr R, Kutscha A, Schmidt H, de Sonneville L, Trefz FK. Effect of high-dose tyrosine supplementation on brain function in adults with phenylketonuria. J Pediatr. 1995;127(6):936-943; https://pubmed.ncbi.nlm.nih.gov/8523192
    45. Attipoe, Selasi, et al. “Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature.” Military Medicine, vol. 180, no. 7, July 2015, pp. 754–765, 10.7205/milmed-d-14-00594; https://academic.oup.com/milmed/article/180/7/754/4160625
    46. Pomeroy, Diane E., et al. “A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel.” Nutrients, vol. 12, no. 2, 20 Feb. 2020, p. 545, 10.3390/nu12020545; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071459/
    47. Waldron, M., et al. May 2018. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine vol. 48,5; 1247-53. https://pubmed.ncbi.nlm.nih.gov/29546641
    48. Ripps, H. et al. Nov. 2012. “Review: Taurine: A “Very Essential Amino Acid.” Molecular Vision vol. 18. 2673-86. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501277/
    49. Chen, C. et al. Aug. 2019. “Roles of Taurine in Cognitive Function of Physiology, Pathologies, and Toxication.” Life Sciences vol. 15, 231; https://pubmed.ncbi.nlm.nih.gov/31220527/
    50. Guizoni, D. et al. Jan. 2020. “Modulation of Endothelium-Derived Nitric Oxide Production and Activity by Taurine and Taurine-Conjugated Bile Acids.” Nitric Oxide vol. 94,1; 48-53; https://www.sciencedirect.com/science/article/abs/pii/S1089860319302113
    51. Jong, Chian Ju, et al. “The Role of Taurine in Mitochondria Health: More than Just an Antioxidant.” Molecules, vol. 26, no. 16, 13 Aug. 2021, p. 4913, 10.3390/molecules26164913; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8400259/
    52. Vijaya Juturu V., Komorowski, JR. 2002. US7576132B2 – “Arginine Silicate Inositol Complex and use Thereof.” The United States Patent and Trademark Office. https://patents.google.com/patent/US7576132
    53. Gills JL, Campitelli A, Jones M, et al. Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults. Nutrients. 2021;13(12):4272. Published 2021 Nov 26. doi:10.3390/nu13124272; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703995/
    54. Komorowski, J., Perez, S., & Sylla, S; “Arginase Inhibition by Inositol-stabilized Arginine Silicate (ASI; Nitrosigine); A Novel Mechanism by which ASI Enhances Arginine Bioavailability”; Poster Presentation. Retrieved from https://www.eventscribe.com/2018/Nutrition2018/ajaxcalls/PosterInfo.asp?efp=UlhTRFpZVVI0ODYw&PosterID=146640&rnd=0.1401379
    55. Sandler, D., et al. June 2016. “Absorption of Bonded Arginine Silicate Compared to Individual Arginine and Silicon Components.” Journal of the International Society of Sports Nutrition vol. 13. https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0144-9
    56. Rood-Ojalvo, S. et al. Sep. 2015. “The Benefits of Inositol-Stabilized Arginine Silicate as a Workout Ingredient.” Journal of the International Society of Sports Nutrition vol. 12(S1). https://jissn.biomedcentral.com/articles/10.1186/1550-2783-12-S1-P14
    57. Kalman, D. et al. June 2018. “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) On Cognitive Flexibility.” Nutrients https://blog.priceplow.com/wp-content/uploads/nitrosigine-cognitive-flexibility-issn-2018.pdf
    58. Suzuki, I., Sakuraba, K., Horiike, T. et al. A combination of oral l-citrulline and l-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial. Eur J Appl Physiol 119, 1075–1084; 2019; https://link.springer.com/article/10.1007/s00421-019-04097-7
    59. Vanhatalo, Anni, et al. “Acute and Chronic Effects of Dietary Nitrate Supplementation on Blood Pressure and the Physiological Responses to Moderate-Intensity and Incremental Exercise.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 299, no. 4, Oct. 2010, pp. R1121–R1131, 10.1152/ajpregu.00206.2010; https://journals.physiology.org/doi/full/10.1152/ajpregu.00206.2010
    60. Mor A, Yılmaz AK, Acar K, Birinci MC, Ipekoglu G. Does Nitric Oxide Intake Affect Post-Exercise Recovery in Athletes? A Study on Cocoa, Caffeine and Nitric Oxide Supplement: Effect of Nitric Oxide Intake in Athletes. Progr Nutr [Internet]. 2020 Sep. 30 [cited 2022 May 4];22(3):e2020007; https://www.mattioli1885journals.com/index.php/progressinnutrition/article/view/8529
    61. Evans, M., Zakaria, N., & Marzuk, M; “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) in Preventing the Decline of Cognitive Function Caused by Strenuous Exercise”; International Society of Sports Nutrition 2018 Conference; 2018; https://blog.priceplow.com/wp-content/uploads/nitrosigine-preventing-cognitive-decline-caused-by-strenuous-exercise.pdf
    62. Kalman, D., Hewlings, S., Sylla, S., Ojalvo, S., & Komorrowski, J; “An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) on cognitive flexibility”; Nutrients; 2016; https://blog.priceplow.com/wp-content/uploads/nitrosigine-cognitive-flexibility-issn-2018.pdf
    63. Legaz, M. et al. Feb. 1983. “Endogenous Inactivators of Arginase, L-Arginine Decarboxylase, and Agmatine Amidinohydrolase in Evernia prunastri Thallus.” Plant Physiology vol. 71,1; 300-2. https://pubmed.ncbi.nlm.nih.gov/16662821
    64. Morrissey J. et al. Jan. 1997. “Agmatine Activation of Nitric Oxide Synthase in Endothelial Cells.” Proceedings of the Association of American Physicians vol. 109,1;51-7. https://pubmed.ncbi.nlm.nih.gov/9010916/
    65. Freitas, Andiara E., et al. “Agmatine, a Potential Novel Therapeutic Strategy for Depression.” European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, vol. 26, no. 12, 1 Dec. 2016, pp. 1885–1899, 10.1016/j.euroneuro.2016.10.013; https://pubmed.ncbi.nlm.nih.gov/27836390/
    66. Wallace JMW, McCormack JM, McNulty H, et al. Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women. Br J Nutr. 2012;108(7):1264-1271. doi:10.1017/S000711451100674X. https://pubmed.ncbi.nlm.nih.gov/22172554
    67. Cohen BM, Renshaw PF, Stoll AL, Wurtman RJ, Yurgelun-Todd D, Babb SM. Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study. JAMA. 1995;274(11):902-907; https://pubmed.ncbi.nlm.nih.gov/7674505
    68. Sanders LM, Zeisel SH; “Choline: Dietary Requirements and Role in Brain Development;” Nutrition today; 2007;42(4):181-186; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518394/
    69. David Bellar, et al; “The Effect of 6 Days of Alpha Glycerylphosphorylcholine on Isometric Strength.” Journal of the International Society of Sports Nutrition; BioMed Central; 17 Nov. 2015; https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0103-x
    70. Tim Ziegenfuss, et al; “Acute Supplementation with Alpha-Glycerylphosphorylcholine Augments Growth Hormone Response to, and Peak Force Production during Resistance Exercise.”; Journal of the International Society of Sports Nutrition; BioMed Central; 17 Sept. 2008; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-5-S1-P15
    71. Dai, Ning et al. “Antioxidant properties of proanthocyanidins attenuate carbon tetrachloride (CCl4)-induced steatosis and liver injury in rats via CYP2E1 regulation.” Journal of medicinal food vol. 17,6 (2014): 663-9. doi:10.1089/jmf.2013.2834 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060835/
    72. Aragonès, Gerard, et al. “Dietary Proanthocyanidins Boost Hepatic NAD+ Metabolism and SIRT1 Expression and Activity in a Dose-Dependent Manner in Healthy Rats.” Scientific Reports, vol. 6, no. 1, 22 Apr. 2016, p. 24977; https://www.nature.com/articles/srep24977
    73. Cantó, Carles et al. “NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus.” Cell metabolism vol. 22,1 (2015): 31-53. doi:10.1016/j.cmet.2015.05.023; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487780/
    74. A. Fernández‐Iglesias, D. Pajuelo, H. Quesada, S. Díaz, C. Bladé, L. Arola, M.J. Salvadó, M. Mulero. Grape seed proanthocyanidin extract improves the hepatic glutathione metabolism in obese Zucker rats. Mol. Nutr. Food Res., 58 (2014), pp. 727-737; https://pubmed.ncbi.nlm.nih.gov/24338985/
    75. Joy, J. et al; “Supplementation with a Proprietary Blend of Ancient Peat and Apple Extract May Improve Body Composition without Affecting Hematology in Resistance-Trained Men;” Applied Physiology Nutrition and Metabolism; (2015); https://www.researchgate.net/publication/283077352_Supplementation_with_a_Proprietary_Blend_of_Ancient_Peat_and_Apple_Extract_May_Improve_Body_Composition_without_Affecting_Hematology_in_Resistance-Trained_Men
    76. Joy JM et al., “Ancient peat and apple extracts supplementation may improve strength and power adaptations in resistance trained men,” BMC Complementary and Alternative Medicine; 2016; https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/s12906-016-1222-x
    77. Nemzer, Boris V., et al. “Oxidative Stress or Redox Signalling – New Insights into the Effects of a Proprietary Multifunctional Botanical Dietary Supplement.” Free Radical Research, vol. 52, no. 3, 1 Mar. 2018, pp. 362–372, 10.1080/10715762.2017.1390228; https://pubmed.ncbi.nlm.nih.gov/29110555/
    78. Kesarwani, Kritika et al. “Bioavailability enhancers of herbal origin: an overview.” Asian Pacific journal of tropical biomedicine vol. 3,4 (2013): 253-66. doi:10.1016/S2221-1691(13)60060-X; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634921/

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