5% Nutrition KILL IT RTD: Rich Piana Power in the Palm of Your Hands

For years, 5% Nutrition has led the industry in the “more of everything” category of bodybuilding supplements and sports nutrition. This is an excellent case of a brand taking on a personality that mirrors its founder. Rich Piana, after all, could certainly not be accused of moderation or having a conservative mindset. Everything he did was big.

5% Nutrition KILL IT RTD

5% Nutrition KILL IT is now in RTD form, yet with far more caffeine than the OG pre — 400mg!

This legacy continues to roll on at 5% Nutrition, where they are maintaining this same “more is better” ethos. Now, we’re getting one of their classic formulas in one of our favorite delivery formats.

KILL IT RTD: Go Big or Go Home in One Huge Chug

Rich Piana’s powdered KILL IT pre-workout formula has been around since 2015. It was a hit then, and it’s a hit now. 5% Nutrition even gave it an extra boost and released KILL IT RELOADED.

Now, they’re revisiting the old KILL IT formula, this time in a new package and form factor – and a lot more caffeine. We’re finally getting a KILL IT RTD, meaning we get to take classic pre-workout in the most convenient manner of all time: a pre-made drink. Just twist off the top, drink, and prepare for Rich Piana style power.

It has 400 milligrams of caffeine per bottle, so you better be Rich-ready. This article gets into the label, which brings a ton of glycerol for pumps as well. Let’s check in on prices, get you signed up for our 5% Nutrition news alerts, and then have at it:

Rich Piana 5% Nutrition Kill It RTD – Deals and Price Drop Alerts

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5% Nutrition KILL IT RTD Ingredients – How It Works

  • Glycerine – 10g

    5% Nutrition KILL IT RTD Ingredients

    Glycerol, also known as glycerine, is a sugar alcohol that attracts and retains water it encounters.[1] Once consumed, glycerol disperses throughout the body and increases total water volume, resulting in hyperhydration when consumed with enough water.[2] This unique hydration pump creates a more significant and “swole” feeling in the gym.

    While most research on glycerol focuses on endurance, studies have shown that it also increases power output.[3] In addition to providing hydration and increasing total volume, glycerol improves heat tolerance and reduces the strain on the cardiovascular system when training[4]. It increases blood flow, which is an additional benefit when combined with other ingredients such as citrulline and Nitrosigine.[5]

    Glycerol consumption has been shown to enhance water retention, endurance, and cell volumization. This leads to more gains, more size, and more volume. What more could you ask for?

    While most pre workout powders that utilize glycerol (Kill It Reloaded included) are forced to use lower doses since the osmolyte loves to suck up water and clump, we normally don’t see doses this big. But in liquid form factor, we can get a huge 10 gram dose!

    Drink this one with plenty of water during your workouts (either with ALL DAY YOU MAY or the new 5% Nutrition Hydrate STK), and get ready to see the muscle bellies shine with hydration pumps galore. Next up? Nitric oxide.

  • L-Citrulline – 4g

    5% Nutrition KILL IT RTD

    L-citrulline is a well-known nitric oxide booster among athletes. This amino acid helps the body produce more L-arginine, which in turn generates more nitric oxide (NO),[6] resulting in vasodilation, the relaxation and expansion of blood vessels.[7,8]

    This effect increases blood flow, leading to muscle pumps, reduced blood pressure, and better nutrient delivery. Unlike direct arginine supplementation, which the digestive system breaks down quickly, L-citrulline is more effective in humans.[7]

    L-citrulline is converted into arginine later on, allowing the body to produce more nitric oxide without wrecking the gut.[9,10] In addition to promoting blood flow and pumps, L-citrulline also improves ATP production, work output, and recovery.

    Another great dose – at 3 grams, we have clinical evidence that nitric oxide levels get boosted. 5% Nutrition goes 33% above that though, and there’s still some more NO action coming from Nitrosigine below!

  • Beta-Alanine – 3.2g

    Kill It Reloaded

    Compare to KILL IT RELOADED, which has reloaded in a big way. Hope you like getting pumped up!

    Beta alanine, a well-known endurance-boosting amino acid, combines with L-histidine to generate more carnosine.[11,12] Carnosine helps buffer lactic acid in muscle tissue, prolonging endurance. Several studies and meta-analyses have demonstrated beta alanine’s efficacy in improving endurance for exercises lasting from 30 seconds to 10 minutes,[13] including endurance sports such as rowing, running, swimming, cycling, and weightlifting.

    In addition, a 2019 safety study found that beta alanine was non-toxic and did not adversely affect consumers.[14] Although the high dose of beta alanine used in this product may cause a tingling effect (paresthesia), it is considered safe.

    The 3.2 gram dose of beta alanine in Kill It RTD combined with 400 milligrams of caffeine is sure to provide a noticeable effect you can feel. This is the clinical daily dose in tons of studies, so you are likely to get to carnosine saturation expeditiously with Kill It RTD as your pre-workout.

  • Taurine – 2g

    To partner with the glycerol above (and betaine below), taurine promotes increased water retention in cells and “osmotic swelling“,[15] protecting the mitochondria from stress and promoting better energy production throughout the body.[16]

    Taurine Endurance

    Taurine’s effect on endurance, with success in doses anywhere from 1 gram to 6 grams – and on the first use too.[17]

    Taurine is used for multiple purposes in sports nutrition, ranging from increased cell volumization pumps to increased endurance. The major endpoint of taurine consumption is endurance, and a meta-analysis of ten studies that used taurine concluded that it is useful for promoting endurance when used daily in doses ranging from 1 to 6 grams, and it generally works on the first use.[17]

    Taurine also functions as an antioxidant by fighting oxidative stress, improving the absorption of lipids, and helping to improve nitric oxide production and blood flow.[18] Additionally, taurine has a positive effect on concentration and cognition, which is likely due to the importance of blood and water flow to the brain.[19]

    This ingredient is incredible, and we’re very pleased to see more and more brands like 5% Nutrition get away from the same old one-gram dose and move into bigger and better doses – just the way Rich would want it!

  • Betaine – 1g

    Betaine, also known as trimethylglycine (TMG), is an inexpensive, safe, and effective substance that falls under the category of ergogenic aids. Ergogenic aids are substances or techniques that can enhance athletic performance, including well-known supplements like caffeine and creatine.

    5% Nutrition Hydrate STK

    5% Nutrition Hydrate STK is a well-formulated electrolyte-laden stick pack with plenty of potassium and a mood-booster known as SAMe that we don’t see often enough!

    Betaine can increase the production of adenosine triphosphate (ATP),[20] the usable form of energy that cells consume to perform work, leading to improved cellular function and better athletic and cognitive performance. It achieves this by donating methyl groups to critical processes involved in cellular metabolism,[21] making it one of the most powerful methyl donors known to nutritional science.[22] Betaine’s ability to provide methyl groups is also beneficial to cardiovascular health, as it can help lower homocysteine levels,[23] an amino acid that can increase the risk of serious cardiovascular disease.[24]

    Betaine also acts as an osmolyte, which affects the behavior of biological fluids in the body. Specifically, it increases osmotic pressure around the cells, which draws extra water into the cells. This hyperhydration effect can lead to better access to nutrients,[25,26] improved resistance to heat shock,[27] and can ultimately enhance strength, power, and body composition when dosed a bit higher.[28-33]

    So if you want to get serious, you’ll need to find 1.5 grams more of betaine in your stack. One unique place you can get more betaine is actually in 5% Nutrition Core Beet Root if you’re looking to maximize cardiovascular health.

  • Inositol-Stabilized Arginine Silicate (Nitrosigine) – 750mg

    To improve arginine’s effectiveness, researchers at Nutrition21 created and patented inositol-stabilized arginine silicate, which they named Nitrosigine. This ingredient increases the bioavailability of L-arginine, keeping it around long enough to generate a substantial nitric oxide boost that lasts longer than plain L-arginine or L-arginine HCl[34,35]. Nitrosigine also limits arginase activity,[36] preventing the breakdown of arginine.

    Nitrosigine Arginine Inositol Silicate

    Not only does Nitrosigine immediately boost N.O. levels, it keeps them elevated for a period of up to 2 weeks!

    At 1500 milligrams per day — which we unfortunately don’t have here — Nitrosigine has been shown to be beneficial for cognitive performance, energy, focus, and overall cognitive flexibility,[35,37-42] and it has been shown to prevent cognitive decline caused by extreme exercise.[35,37]

    Finally, Nitrosigine can also reduce muscle inflammation and damage in a similar way to citrulline.[43]

    While we don’t have the dose that’s most clinically studied, we’re very confident that this will still provide a boost, especially with all of the other pump agents. Nitrosigine’s synergistic effects with citrulline make Kill It RTD that much more effective.

  • Caffeine – 400mg

    As far as caffeine goes, Kill It RTD opted out of erring on the light side. This is definitely in the higher-stim category of pre-workout supplements. Using a blend of caffeine anhydrous, caffeine citrate, and dicaffeine malate, Kill It RTD yields 400 milligrams of caffeine per container.

    High Dose Caffeine Performance

    Known since 1991, very high dose caffeine can seriously boost performance.[44] As you can see, it’s quite variable amongst users – future research would show that caffeine’s effects depend on your genotype.

    Once you start dosing caffeine in the 400 milligram range, some studies have suggested direct strength increases as well, depending on bodyweight. Two reviews have shown that a caffeine dose of around 5-6 milligrams per kilogram of bodyweight can significantly boost strength.[45,46]

  • Tripotassium Citrate Monohydrate – 196mg

    Tripotassium citrate monohydrate is the tribasic potassium salt of citric acid, also known as potassium citrate. Potassium is considered a “shortfall nutrient” by researchers,[47] indicating that most Americans do not consume enough through their diet. Potassium-sodium interactions are the basis of much of the research on potassium and cardiovascular health.[47] Studies have demonstrated that higher potassium:sodium intake ratios can lower blood pressure and reduce the risk of heart disease more effectively than focusing solely on sodium.[48,49]

    Potassium can also help improve bone mineral density by enhancing calcium retention.[50,51] However, it is challenging to consume enough potassium because the suggested daily intake was set at 4700 milligrams per day in 2004,[52] but most Americans only consume about half of that.[53] This makes the supplementation of potassium an important consideration when looking to optimize performance and the balance with sodium.

  • L-Theanine – 100mg

    400 milligrams of caffeine seem too high? Well this may help take the edge off a bit.

    5% Nutrition Core KSM-66 Ashwagandha

    Need to reduce some cortisol? Then ashwagandha is your herb and this is your supplement. 5% Nutrition Core KSM-66 is another way to try to reduce the intensity of caffeine.

    L-theanine is a naturally occurring amino acid found in Camellia sinensis, the plant from which white, green, oolong, and black teas are derived. In the human brain, theanine acts as a neurotransmitter[54] and has a relaxing effect that reduces anxiety by inhibiting neurotransmission[55-57] without causing sedation.

    Theanine’s ability to synergize with caffeine has been discovered to enhance mood and cognition, outperforming the effects of either ingredient alone.[58] The combination of theanine and caffeine improves mental accuracy, reduces fatigue, speeds up reaction times, and increases numerical working memory.

    It also improves the ability to judge written texts and increases alertness.[58] Theanine increases attention and reduces reaction time, particularly in stressed individuals. Furthermore, theanine is known to improve sleep quality and reduce resting heart rate,[59] and it does this by upregulating GABA,[60] which is a calming neurotransmitter that inhibits neurotransmission.

  • Coconut Water Powder – 100mg

    In addition to the tripotassium citrate monohydrate, we get a little bit of extra potassium from coconut water power, along with a nice serving of other electrolytes. Coconut water powder has been validated by research as an effective hydration beverage.[61]

  • Sodium Citrate Dihydrate – 86mg

    Sodium helps maintain proper fluid balance within cells and outside of cells in the body,[62] making it vital for muscle contraction and nerve signal transmission – both essential for athletes.

    5% Nutrition KILL IT RTD

    When athletes sweat during intense training sessions but only replace fluids with water, their sodium levels can deplete, leading to poor performance, muscle cramping, and in severe cases, hyponatremia.[63] Therefore, it is important to at least replace what has been lost. Generally, humans need to replace around 2 grams of sodium per day, which is why many organizations recommend a daily intake of 2.3 grams (equivalent to a teaspoon of table salt).[64] However, for those who train hard and sweat profusely, sodium requirements are generally higher.

    5% Nutrition has opted for the citrate form of sodium, which is different from the commonly used sodium chloride (table salt) found in other products. One study found that high-dose sodium citrate improved running performance in elite athletes compared to a placebo.[65]

  • Huperzia serrata Club Moss Extract – 10mg

    Huperzine A, a constituent of Huperzia serrata club moss extract, can enhance acetylcholine levels by slowing down its degradation process, rather than increasing its production.

    This is achieved through the inhibition of acetylcholinesterase, an enzyme responsible for breaking down acetylcholine.[66] By blocking this enzyme, huperzine A can effectively increase acetylcholine levels in the brain.[67]

    The reason why we want to increase acetylcholine levels is that it is known as the learning neurotransmitter, facilitating communication between neurons and supporting long-term potentiation (LTP).

    Moreover, huperzine A acts as a robust antioxidant and can safeguard neuronal mitochondria against oxidative stress damage.[68]

    Rich Piana KILL IT RTD

    As for this dose, usually it’s standardized to 1% Huperzine A, but we’re not sure with this label. In general, we’d think this is a 100 microgram dose, which is right in the median range we normally see.

All 5% Nutrition KILL IT RTD flavors

5% Nutrition KILL IT RTD is launching in two flavors: Tropical Punch and Wild Berry. Check out our up-to-date list of KILL IT RTD flavors below:

    Quick, Convenient Intensity

    We love ready-to-drink formulas. They’re quick, easy, and convenient. There’s no need to carry around a tub of powder when you’re on the move. Simply throw a bottle in your gym bag or ammo can, grab your keys, and drink on the way. You know you’re getting the right dosages every time.

    As is the case with most, if not all, 5% Nutrition products, the KILL IT formula holds nothing back. With strong doses of glycerine, citrulline, and caffeine, it’s virtually impossible to have a sluggish workout when you’re powered by one of these.

    Rich Piana 5% Nutrition Kill It RTD – Deals and Price Drop Alerts

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    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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    1. PubChem. “Glycerol.” Pubchem.ncbi.nlm.nih.gov, https://pubchem.ncbi.nlm.nih.gov/compound/753
    2. Nelson, Jeff L, and Robert A Robergs. “Exploring the Potential Ergogenic Effects of Glycerol Hyperhydration.” Sports Medicine, vol. 37, no. 11, 2007, pp. 981–1000, 10.2165/00007256-200737110-00005. https://www.ncbi.nlm.nih.gov/pubmed/17953468
    3. Patlar, Suleyman, et al. “The Effect of Glycerol Supplements on Aerobic and Anaerobic Performance of Athletes and Sedentary Subjects.” Journal of Human Kinetics, vol. 34, no. 1, 1 Oct. 2012, pp. 69–79, 10.2478/v10078-012-0065-x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590833/
    4. Montner, P., et al. “Pre-Exercise Glycerol Hydration Improves Cycling Endurance Time.” International Journal of Sports Medicine, vol. 17, no. 1, 1 Jan. 1996, pp. 27–33, 10.1055/s-2007-972804. https://pubmed.ncbi.nlm.nih.gov/8775573/
    5. Anderson, M. J., et al. “Effect of Glycerol-Induced Hyperhydration on Thermoregulation and Metabolism during Exercise in the Heat.” International Journal of Sport Nutrition, vol. 11, no. 3, 29 Sept. 2001, pp. 315–333. https://research.monash.edu/en/publications/effect-of-glycerol-induced-hyperhydration-on-thermoregulation-and
    6. Bailey, SJ et al.; “l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans.”; Journal of Applied Physiology; 119(4) pp. 385-395; 2015; https://journals.physiology.org/doi/full/10.1152/japplphysiol.00192.2014
    7. Schwedhelm, Edzard et al.; “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism.”; British journal of clinical pharmacology vol. 65,1 (2008): 51-9.; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291275/
    8. Archer, S L, et al. “Nitric Oxide and CGMP Cause Vasorelaxation by Activation of a Charybdotoxin-Sensitive K Channel by CGMP-Dependent Protein Kinase.” Proceedings of the National Academy of Sciences of the United States of America, vol. 91, no. 16, 1994, pp. 7583–7, 10.1073/pnas.91.16.7583; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC44446/
    9. Grimble, George K. “Adverse Gastrointestinal Effects of Arginine and Related Amino Acids.” The Journal of Nutrition, vol. 137, no. 6, 1 June 2007, pp. 1693S1701S, 10.1093/jn/137.6.1693s; https://pubmed.ncbi.nlm.nih.gov/17513449/
    10. Kaore, Shilpa N., et al. “Citrulline: Pharmacological Perspectives and Its Role as an Emerging Biomarker in Future.” Fundamental & Clinical Pharmacology, vol. 27, no. 1, 31 July 2012, pp. 35–50, 10.1111/j.1472-8206.2012.01059.x; https://pubmed.ncbi.nlm.nih.gov/23316808/
    11. Hill, C. A., et al. “Influence of β-Alanine Supplementation on Skeletal Muscle Carnosine Concentrations and High Intensity Cycling Capacity.” Amino Acids, vol. 32, no. 2, 28 July 2006, pp. 225–233, doi:10.1007/s00726-006-0364-4. https://pubmed.ncbi.nlm.nih.gov/16868650/
    12. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    13. Saunders, Bryan, et al. “β-Alanine Supplementation to Improve Exercise Capacity and Performance: A Systematic Review and Meta-Analysis.” British Journal of Sports Medicine, vol. 51, no. 8, 18 Oct. 2016, pp. 658–669; https://bjsm.bmj.com/content/51/8/658.long
    14. Dolan, Eimear, et al. “A Systematic Risk Assessment and Meta-Analysis on the Use of Oral β-Alanine Supplementation.” Advances in Nutrition, vol. 10, no. 3, 13 Apr. 2019, pp. 452–463, 10.1093/advances/nmy115; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520041/
    15. Lambert, Ian Henry. “Regulation of the Cellular Content of the Organic Osmolyte Taurine in Mammalian Cells.” Neurochemical Research, vol. 29, no. 1, Jan. 2004, pp. 27–63, 10.1023/b:nere.0000010433.08577.96; https://pubmed.ncbi.nlm.nih.gov/14992263/
    16. Jong, Chian Ju, et al. “The Role of Taurine in Mitochondria Health: More than Just an Antioxidant.” Molecules, vol. 26, no. 16, 13 Aug. 2021, p. 4913, 10.3390/molecules26164913; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8400259/
    17. Waldron, M., et al. May 2018. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine vol. 48,5; 1247-53. https://pubmed.ncbi.nlm.nih.gov/29546641
    18. Guizoni, D. et al. Jan. 2020. “Modulation of Endothelium-Derived Nitric Oxide Production and Activity by Taurine and Taurine-Conjugated Bile Acids.” Nitric Oxide vol. 94,1; 48-53; https://www.sciencedirect.com/science/article/abs/pii/S1089860319302113
    19. Chen, C. et al. Aug. 2019. “Roles of Taurine in Cognitive Function of Physiology, Pathologies, and Toxication.” Life Sciences vol. 15, 231; https://pubmed.ncbi.nlm.nih.gov/31220527/
    20. Lee I. Betaine is a positive regulator of mitochondrial respiration. Biochem Biophys Res Commun. 2015 Jan 9;456(2):621-5. doi: 10.1016/j.bbrc.2014.12.005; https://pubmed.ncbi.nlm.nih.gov/25498545/
    21. Zhao, Guangfu et al. “Betaine in Inflammation: Mechanistic Aspects and Applications.” Frontiers in immunology vol. 9 1070. 24 May. 2018, doi:10.3389/fimmu.2018.01070 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976740/
    22. Craig, Stuart AS. “Betaine in Human Nutrition.” The American Journal of Clinical Nutrition, vol. 80, no. 3, 1 Sept. 2004, pp. 539–549, 10.1093/ajcn/80.3.539. https://www.sciencedirect.com/science/article/pii/S0002916522035602
    23. Olthof, M. R., & Verhoef, P. (2005). Effects of betaine intake on plasma homocysteine concentrations and consequences for health. Current drug metabolism, 6(1), 15-22; https://pubmed.ncbi.nlm.nih.gov/15720203
    24. Ganguly, Paul, and Sreyoshi Fatima Alam. “Role of homocysteine in the development of cardiovascular disease.” Nutrition journal vol. 14 6. 10 Jan. 2015, doi:10.1186/1475-2891-14-6; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326479/
    25. Boel De Paepe; “Osmolytes as Mediators of the Muscle Tissue’s Responses to Inflammation: Emerging Regulators of Myositis with Therapeutic Potential”; EMJ Rheumatol. 2017;4undefined:83-89; https://www.emjreviews.com/rheumatology/article/osmolytes-as-mediators-of-the-muscle-tissues-responses-to-inflammation-emerging-regulators-of-myositis-with-therapeutic-potential/
    26. Cholewa, Jason M et al. “Effects of betaine on body composition, performance, and homocysteine thiolactone.” Journal of the International Society of Sports Nutrition vol. 10,1 39. 22 Aug. 2013, doi:10.1186/1550-2783-10-39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844502/
    27. Caldas, Teresa, et al. “Thermoprotection by Glycine Betaine and Choline.” Microbiology, vol. 145, no. 9, 1 Sept. 1999, pp. 2543–2548, 10.1099/00221287-145-9-2543; https://pubmed.ncbi.nlm.nih.gov/10517607/
    28. Roti, M; “Homocysteine, Lipid and Glucose Responses to Betaine Supplementation During Running in the Heat”; Medicine & Science in Sports & Exercise: May 2003 – Volume 35 – Issue 5 – p S271; https://journals.lww.com/acsm-msse/Fulltext/2003/05001/HOMOCYSTEINE,_LIPID_AND_GLUCOSE_RESPONSES_TO.1501.aspx
    29. Armstrong, Lawrence E, et al. “Influence of Betaine Consumption on Strenuous Running and Sprinting in a Hot Environment.” Journal of Strength and Conditioning Research, vol. 22, no. 3, May 2008, pp. 851–860, 10.1519/jsc.0b013e31816a6efb; https://pubmed.ncbi.nlm.nih.gov/18438230
    30. Hoffman, Jay R, et al. “Effect of Betaine Supplementation on Power Performance and Fatigue.” Journal of the International Society of Sports Nutrition, vol. 6, no. 1, 27 Feb. 2009, 10.1186/1550-2783-6-7; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-6-7
    31. Lee, Elaine C, et al. “Ergogenic Effects of Betaine Supplementation on Strength and Power Performance.” Journal of the International Society of Sports Nutrition, vol. 7, no. 1, 2010, p. 27, 10.1186/1550-2783-7-27; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-27
    32. Trepanowski, John F, et al. “The Effects of Chronic Betaine Supplementation on Exercise Performance, Skeletal Muscle Oxygen Saturation and Associated Biochemical Parameters in Resistance Trained Men.” Journal of Strength and Conditioning Research, vol. 25, no. 12, Dec. 2011, pp. 3461–3471, 10.1519/jsc.0b013e318217d48d; https://pubmed.ncbi.nlm.nih.gov/22080324/
    33. Pryor, J Luke, et al. “Effect of Betaine Supplementation on Cycling Sprint Performance.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 3 Apr. 2012, 10.1186/1550-2783-9-12; https://jissn.biomedcentral.com/articles/10.1186/1550-2783-9-12
    34. Sandler, D., et al. June 2016. “Absorption of Bonded Arginine Silicate Compared to Individual Arginine and Silicon Components.” Journal of the International Society of Sports Nutrition vol. 13. https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0144-9
    35. Komorowski, J., et al. Apr. 2016. “A Pharmacokinetic Evaluation of the Duration of Effect of Inositol- Stabilized Arginine Silicate and Arginine Hydrochloride in Healthy Adult Males.” The Journal of the Federation of American Societies for Experimental Biology vol. 30. https://www.fasebj.org/doi/abs/10.1096/fasebj.30.1_supplement.690.17
    36. Komorowski, J., Perez, S., & Sylla, S; “Arginase Inhibition by Inositol-stabilized Arginine Silicate (ASI; Nitrosigine); A Novel Mechanism by which ASI Enhances Arginine Bioavailability”; Poster Presentation; Retrieved from: https://www.eventscribe.com/2018/Nutrition2018/ajaxcalls/PosterInfo.asp?efp=UlhTRFpZVVI0ODYw&PosterID=146640&rnd=0.1401379
    37. Rood-Ojalvo, S. et al. Sep. 2015. “The Benefits of Inositol-Stabilized Arginine Silicate as a Workout Ingredient.” Journal of the International Society of Sports Nutrition vol. 12(S1). https://jissn.biomedcentral.com/articles/10.1186/1550-2783-12-S1-P14
    38. Kalman, D. et al. 2015. “A Clinical Evaluation to Determine the Safety, Pharmacokinetics, and Pharmacodynamics of an Inositol-Stabilized Arginine Silicate Dietary Supplement in Healthy Adult Males.” Clinical Pharmacology: Advances and Applications, vol. 103. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603712/
    39. Evans, M., et al., June 2018. “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) in Preventing the Decline of Cognitive Function Caused by Strenuous Exercise.” International Society of Sports Nutrition 2018 Conference. https://blog.priceplow.com/wp-content/uploads/nitrosigine-preventing-cognitive-decline-caused-by-strenuous-exercise.pdf
    40. Evans, M. et al. July 2020. “Inositol-Stabilized Arginine Silicate Improves Post Exercise Cognitive Function in Recreationally Active, Healthy Males: A Randomized, Double-Blind, Placebo-Controlled Crossover Study.” Journal of Exercise and Nutrition vol. 3,3. https://www.journalofexerciseandnutrition.com/index.php/JEN/article/view/69 (full-text PDF)
    41. Kalman, D. et al. June 2018. “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) On Cognitive Flexibility.” Nutrients https://blog.priceplow.com/wp-content/uploads/nitrosigine-cognitive-flexibility-issn-2018.pdf
    42. Gills, Joshua L., et al. “Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults.” Nutrients, vol. 13, no. 12, 1 Dec. 2021, 10.3390/nu13124272; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8703995/
    43. Ojalvo, P., Komorowski, S. Oct. 2017. “Effect of Bonded Arginine Silicate on Inflammatory Markers and Arthritis.” FASEB Journal vo. 31. https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.166.5
    44. Graham, T. E., and L. L. Spriet. “Performance and Metabolic Responses to a High Caffeine Dose during Prolonged Exercise.” Journal of Applied Physiology, vol. 71, no. 6, Dec. 1991, pp. 2292–2298, doi:10.1152/jappl.1991.71.6.2292; https://pubmed.ncbi.nlm.nih.gov/1778925/
    45. Iraki, J., Fitschen, P., Espinar, S. and Helms, E. (2019). Nutrition Recommendations for Bodybuilders in the Off-Season: A Narrative Review. Sports, 7(7), p.154. https://www.mdpi.com/2075-4663/7/7/154/htm
    46. Pickering, Craig, and John Kiely. “Are the Current Guidelines on Caffeine Use in Sport Optimal for Everyone? Inter-individual Variation in Caffeine Ergogenicity, and a Move Towards Personalised Sports Nutrition.” Sports medicine (Auckland, N.Z.) vol. 48,1 (2018): 7-16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752738/
    47. Weaver, Connie M. “Potassium and Health.” Advances in Nutrition, vol. 4, no. 3, 1 May 2013, pp. 368S377S, 10.3945/an.112.003533; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3650509/
    48. Fulgoni, Victor L., et al. “Foods, Fortificants, and Supplements: Where Do Americans Get Their Nutrients?” The Journal of Nutrition, vol. 141, no. 10, 24 Aug. 2011, pp. 1847–1854, 10.3945/jn.111.142257; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3174857/
    49. Cook, Nancy R. “Joint Effects of Sodium and Potassium Intake on Subsequent Cardiovascular Disease.” Archives of Internal Medicine, vol. 169, no. 1, 12 Jan. 2009, p. 32, 10.1001/archinternmed.2008.523; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2629129/
    50. Lemann, Jacob, et al. “Potassium Administration Increases and Potassium Deprivation Reduces Urinary Calcium Excretion in Healthy Adults.” Kidney International, vol. 39, no. 5, May 1991, pp. 973–983, 10.1038/ki.1991.123; https://pubmed.ncbi.nlm.nih.gov/1648646/
    51. Gregory, Naina Sinha, et al. “Potassium Citrate Decreases Bone Resorption in Postmenopausal Women with Osteopenia: A Randomized, Double-Blind Clinical Trial” Endocrine Practice, vol. 21, no. 12, Dec. 2015, pp. 1380–1386, 10.4158/ep15738.or; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5558825/
    52. Institute of Medicine of the National Academies; “Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate”; The National Academies Press; 2004; https://nal.usda.gov/sites/default/files/fnic_uploads/water_full_report.pdf
    53. Fulgoni, Victor L., et al. “Foods, Fortificants, and Supplements: Where Do Americans Get Their Nutrients?” The Journal of Nutrition, vol. 141, no. 10, 24 Aug. 2011, pp. 1847–1854, 10.3945/jn.111.142257; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3174857/
    54. Juneja, L. R., et al; “L-Theanine-a Unique Amino Acid of Green Tea and Its Relaxation Effect in Humans.;” Trends in Food Science & Technology; Elsevier; 17 Dec. 1999; https://www.sciencedirect.com/science/article/abs/pii/S0924224499000448
    55. Lu, Kristy, et al; “The Acute Effects OfL-Theanine in Comparison with Alprazolam on Anticipatory Anxiety in Humans.”; Human Psychopharmacology: Clinical and Experimental; vol. 19; no. 7; 2004; pp. 457–465; https://espace.library.uq.edu.au/view/UQ:284103
    56. Haskell, C F, et al; “The Effects of L-Theanine, Caffeine and Their Combination on Cognition and Mood.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Feb. 2008; https://www.ncbi.nlm.nih.gov/pubmed/18006208
    57. Lu, K; The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans; Human Psychopharmacology, 19 7: 457-465; 2004; http://espace.library.uq.edu.au/view/UQ:284103
    58. Haskell, C F, et al; “The Effects of L-Theanine, Caffeine and Their Combination on Cognition and Mood.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Feb. 2008; https://www.ncbi.nlm.nih.gov/pubmed/18006208
    59. Williams, Jackson, et al. “L-Theanine as a Functional Food Additive: Its Role in Disease Prevention and Health Promotion.” Beverages, vol. 2, no. 2, 30 May 2016, p. 13; 10.3390/beverages2020013; https://www.mdpi.com/2306-5710/2/2/13/htm
    60. Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30; https://pubmed.ncbi.nlm.nih.gov/17182482/
    61. Ismail, I., et al. 2007. “Rehydration with Sodium-Enriched Coconut Water After Exercise-Induced Dehydration.” The Southeast Asian Journal of Tropical Medicine and Public Health vol. 38,4 (2007): 769-85; https://pubmed.ncbi.nlm.nih.gov/17883020/
    62. Strazzullo P., Leclercq C.; “Sodium.” Advanced Nutrition; March 2014; 5(2) 188-190; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951800/
    63. Valentine, V. 2007. “The Importance of Salt in the Athlete’s Diet.” Current Sports Medicine Reports vol. 6,4 (2007): 237-40; https://journals.lww.com/acsm-csmr/Fulltext/2007/08000/The_Importance_of_Salt_in_the_Athlete_s_Diet.9.aspx
    64. Mente, Andrew, et al. “Sodium Intake and Health: What Should We Recommend Based on the Current Evidence?” Nutrients, vol. 13, no. 9, 1 Sept. 2021, p. 3232, 10.3390/nu13093232; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8468043/
    65. Shave, R., et al. “The Effects of Sodium Citrate Ingestion on 3,000-Meter Time-Trial Performance.” Journal of Strength and Conditioning Research, vol. 15, no. 2, 1 May 2001, pp. 230–234; https://pubmed.ncbi.nlm.nih.gov/11710409/
    66. Tang, X. C., et al. “Effect of Huperzine A, a New Cholinesterase Inhibitor, on the Central Cholinergic System of the Rat.” Journal of Neuroscience Research, vol. 24, no. 2, 1 Oct. 1989, pp. 276–285, 10.1002/jnr.490240220. https://pubmed.ncbi.nlm.nih.gov/2585551/
    67. Damar, U., et al. “Huperzine a as a Neuroprotective and Antiepileptic Drug: A Review of Preclinical Research.” Expert Review of Neurotherapeutics, vol. 16, no. 6, 1 June 2016, pp. 671–680, 10.1080/14737175.2016.1175303. https://pubmed.ncbi.nlm.nih.gov/27086593/
    68. [vi] Gao X., Tang X.C. “Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.”Journal of Neuroscience Research. 2006 May 1;83(6):1048-57; https://pubmed.ncbi.nlm.nih.gov/16493671/

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