Zynamite® in the Wild: Four RTDs Bringing Mango Leaf Focus to the Can

Mango leaf extract in a can. Four brands, three countries, four very different formulas.We lined up XER0, NYNE Focus, 2foods 2Energy, and Neurothena Brain Fuel against the Zynamite S research, including what the trials didn't test.

A functional beverage ingredient has to dissolve, stay in solution, and leave the drink tasting like something people want to finish. Zynamite® S, the water-soluble grade of the mango leaf extract from Nektium Pharma, was developed for that job, according to its maker, and finished cans are starting to appear. This roundup covers four that name Zynamite on the label, spread across the United States, Japan, and the United Kingdom.

From Ingredient to Finished Can

This article is sponsored by PLT Health Solutions, the ingredient's North American supplier. The drink brands didn't sponsor it, and we're not claiming that any of them buy through PLT. Two of the four labels name Zynamite S outright. The other two say Zynamite without naming a grade, so they get their own section and a clear caveat.

If you're new to the ingredient, our Zynamite ingredient guide covers the original extract in depth, and why energy drinks need experiential ingredients makes the case for Zynamite S in the energy drink aisle. New since those articles: the two Zynamite S human trials and a human pharmacokinetic study are now published in peer-reviewed journals. We'll cover what they show, and what they don't, before getting to the cans.

The Four RTDs in This Roundup

• XER0 Energy Drink is a US 12oz can positioned as caffeine-free, and its label names Zynamite S.
• NYNE Focus Lemon Ginger is a 12oz nootropic RTD with a disclosed 150mg of Zynamite S.
• 2foods 2Energy is a Japanese 250mL can, relaunched July 1, 2026, that discloses 140mg of Zynamite.
• Neurothena Brain Fuel is a UK focus drink whose website lists 300mg of Zynamite.

We'll start with the two cans that name Zynamite S, then cover the two that don't.

The Science in Brief

Zynamite® is a Mangifera indica (mango) leaf extract standardized to at least 60% mangiferin, the polyphenol researchers credit for its activity. Three grades exist, and research on one doesn't transfer cleanly to another:

Zynamite is PLT Health's Next-Gen Brain and Body Support Ingredient, harnessing the power of ≥60% mangiferin from mango leaf extract

• Zynamite (original): the standard grade, tested at 300mg in the best-known cognition trial.
• Zynamite S: the water-soluble grade made for beverages, tested at 100mg and 150mg.
• Zynamite PX: the extract paired with quercetin, aimed at sports performance rather than focus.

The Two New Published Studies

For the original grade, that cognition trial gave 70 healthy adults a single 300mg dose. Accuracy across the test battery improved at 30 minutes, 3 hours, and 5 hours, with no interpretable mood effects.^[1]

The Zynamite S research is newer, and it's now peer-reviewed. We reported on the second study in December 2025 (see our coverage of the second Zynamite S study), when only company-reported results were available. Both trials have since been published in Pharmaceuticals.

The first, published April 14, 2025, gave 119 university students 100mg of S, 150mg of S, or placebo in a crossover design. Both doses improved processing speed and cognitive flexibility, with the trail-making gains showing at the 5-hour mark. Mood scores for tension, low mood, and confusion improved too, while verbal memory didn't differ from placebo. The authors reported larger gains at 150mg on some attention and executive-control tasks.^[2]

The second, published July 18, 2026, gave 88 adults aged 18 to 25 a single 100mg dose of S or placebo. Adjusted against placebo, the S group finished the trail-making test faster and completed more symbols on a digit-symbol task at 3 and 5 hours, and trail-making Part A and digit-symbol scores were already ahead of placebo at 30 minutes. Total mood disturbance and fatigue scores were lower than placebo at every time point, although the mood scales were secondary measures, and the drop in confusion from the first trial didn't repeat.^[3]

Second Zynamite S study validates first findings. 100mg delivers 25% faster processing, 24% better mood, 26% less fatigue in 30 minutes. 88 students, non-stimulant, effects last hours. This is how you build clinical evidence.

Note that both trials gave S as capsules to healthy young adults and tracked them for five hours after one dose, so neither tested a finished drink, older adults, or repeated use. Neither included a caffeine comparator, either. Nektium funded the second trial, Nektium employees are among the authors of both papers, and the 2026 paper calls itself an internal replication by the same research group at the same facility, not a confirmation from a separate lab.

The Pharmacokinetic Study

A third paper explains why the S grade exists. A 12-person crossover study published January 21, 2025 in Molecules compared a 60% mangiferin mango leaf extract with its water-soluble monosodium salt form, which Nektium's later trials identify as Zynamite S. Blood exposure to mangiferin over 24 hours was 2.44-fold higher with the soluble form, and the gap was widest in the first two hours at 3.24-fold.^[4] Each arm delivered about 480mg of mangiferin, well above what any can in this roundup supplies, so read it as support for the solubility rationale rather than a dose-equivalence rule.

On mechanism, lab work shows mangiferin inhibits catechol-O-methyltransferase (COMT), an enzyme that breaks down dopamine and other catecholamines. That's one proposed explanation for the extract's effects.^[5] The 2026 trial didn't measure enzyme or neurochemical changes in people.

Two US Cans That Name Zynamite S

• XER0 Energy Drink

  XER0 Energy Drink is a 12oz (355mL) canned energy drink that the brand positions as caffeine-free. Founder Anthony Briganti announced it on June 1, 2025 for a summer 2025 launch, starting with Citrus Burst, which the brand describes as blood orange and citrus with a hint of mango.

  

  PLT Health Solutions: Growth Through Innovation

  The label names Zynamite S without declaring an amount, alongside beta-alanine, L-tyrosine, Cognizin® citicoline, theacrine, Organic Stevia Reb M, Panax ginseng, and S7 (a nitric oxide supporting blend with green coffee bean, green tea, turmeric root, and tart cherry extracts, plus blueberry, broccoli, and kale). B vitamins fill out the panel, with niacin at 16mg, vitamin B6 at 1.7mg, and pantothenic acid at 5mg (each 100% of the Daily Value) in a 0-calorie can.

  Two cautions apply. The brand's caffeine-free positioning shouldn't be read as stimulant-free, since the label does include theacrine, a purine alkaloid marketed for energy and focus. It's not a heavy stimulant like caffeine, but it is still stimulatory.

• NYNE Focus Lemon Ginger

  NYNE Focus Lemon Ginger is the debut release from nootropic beverage brand NYNE, sold in 12-packs of 12oz cans, and we covered it on July 21, 2026 in our NYNE Focus breakdown linked above. The label declares 150mg of Zynamite S (standardized to 60% mangiferin) in a 20-calorie can with 5g of carbohydrate and no sugars, sweetened with allulose and rebaudioside M.

  

  NYNE Focus goes fully caffeine-free and builds around paraxanthine instead. Eight disclosed nootropics, led by 250mg of Cognizin® Citicoline, aim for steady attention through a full workday.

  The rest of the panel is a full nootropic stack: 500mg N-acetyl-L-tyrosine, 250mg Cognizin® citicoline, 200mg L-theanine, 200mg phosphatidylserine, 150mg enfinity® paraxanthine, 100mg CognatiQ® coffee fruit extract, and 50mg RealLionsMane® extract, plus vitamins B6 and B12 at 100% of the Daily Value. There's no caffeine on the label, but the can does carry 150mg of paraxanthine, a caffeine metabolite.

  Like the above, it's caffeine-free, but isn't stimulant-free, given that it has paraxanthine inside.

  The 150mg dose matches the higher of the two amounts tested in the first S trial. That trial used S alone in capsules, and this can adds seven other actives, so the trial's results shouldn't be credited to the can as a whole. Our breakdown covers the full formula.

International Cans That Name Zynamite

The next two labels say Zynamite without adding the S, but it can be assumed it's the S-grade given that they're in beverages:

• 2foods 2Energy

  2foods 2Energy is a Japanese 250mL canned energy drink, relaunched on July 1, 2026 in its Clear Energy Flavor as an official RIZIN energy drink. RIZIN is a Japanese combat sports promotion. The original launched on September 26, 2023 as a joint development with Kagome, the Japanese food and beverage company.

  The brand's product page discloses Zynamite at 140mg per can, standardized to at least 60% mangiferin, and the front of the can promotes it as a caffeine-alternative ingredient. Under Japanese labeling thresholds, the can declares zero calories, zero sugar, and zero caffeine per 100mL, with sucralose as the sweetener. The ingredient list also includes concentrates of blackcurrant, cranberry, pomegranate, blueberry, raspberry, rosehip, and acerola, plus ginger juice, and the label declares 1,550mg of citric acid per can.

  

  PLT Health Solutions' new Zynamite S research shows impressive cognitive benefits. This water-soluble mango leaf extract improves processing speed, cognitive flexibility, and mood with effects lasting up to 5 hours after just one dose.

  At 140mg, the amount would sit inside the 100mg to 150mg range tested for Zynamite S. If the can uses the original grade, 140mg is less than half the 300mg dose studied for that extract. The brand notes that the 140mg figure is the amount at manufacture.

• Neurothena Brain Fuel

  Neurothena Brain Fuel is a UK canned focus drink from founders Tara and Ash, who developed it as a caffeine-free option and credit Ash's science background for the formula. It was on the market by September 2025 in two flavors, Blackcurrant & Apple and Peach & Yuzu.

  The Blackcurrant & Apple label lists Zynamite alongside lion's mane, Korean ginseng, blackcurrant, and rowanberry extracts, with magnesium citrate and zinc bisglycinate. It declares 12 calories and 1.9g of sugars per 100mL, mostly from apple and blackcurrant juice, which works out to about 30 calories and roughly 5g of sugars in a 250mL serving. The brand's website lists 300mg of Zynamite, 500mg of lion's mane, 250mg of ginseng, 250mg of blackcurrant extract, 56mg of magnesium, and 3mg of zinc. The label's magnesium and zinc figures match those last two, but the label doesn't declare the Zynamite amount.

  The 300mg figure matches the dose from the original-grade cognition trial. If the can uses S, it would be twice the highest amount tested in the S trials, and no S trial has tested 300mg. Treat the amount as a website disclosure until it's confirmed on the can.

For Brands and Formulators

Four cans with four separate propositions:

• XER0 sells a caffeine-free energy drink built on amino acids and plant extracts.
• NYNE sells a full nootropic stack around 150mg of Zynamite S.
• 2Energy sells a zero-calorie, zero-sugar can with a combat sports tie-in in Japan
• Neurothena sells a juice-based focus drink with lion's mane and ginseng in the UK.

The shared thread is an ingredient that suppliers and brands position as a caffeine alternative, and the labels show how differently that can look on a shelf.

So what will be next for the popular ingredient?

For brands weighing Zynamite S, the published trials are the evidence base to build around: 100mg and 150mg of S in healthy young adults and five-hour windows. It's the dose you can fit in a can, and at the Zynamite S grade, you can closely fit your product to what was studied. PLT Health works with brands on beverage development and can talk through formats, dosing, and the research, so catch them at SupplySide:

Talk Zynamite S at SupplySide Global 2026

PLT Health Solutions will be at SupplySide Global 2026 in the main expo hall open October 28 to 30 at Mandalay Bay in Las Vegas. If you're a brand, formulator, or product developer weighing a caffeine-alternative ingredient for your next beverage, the booth is a direct way to ask about Zynamite S, dosing, and the published research above.

Check the product links above for availability, and read our full article titled "Zynamite: Next-Generation Brain and Body Support from Mangiferin". To follow new Zynamite coverage and PLT Health Solutions news, sign up for alerts.