New clinical data on Zynamite S shows cognitive and mood benefits within 30 minutes, lasting 3-5 hours. PLT Health Solutions presented research at SupplySide Global 2025 and featured it in CREATEA Mighty Mango. Water-soluble, non-stimulant mental energy.
PLT Health Solutions arrived at SupplySide Global 2025 with elevated status and new science to back it up. As the show's official performance beverage sponsor, PLT used the platform to unveil clinical data positioning Zynamite S as a game-changer for the functional beverage category.
The October Las Vegas event showcased three interconnected elements of PLT's beverage strategy:
- Groundbreaking research on cognitive performance,
- An industry-collaborative proof-of-concept product, and
- Thought leadership discussions about where the category is headed.
Together, these initiatives demonstrate how PLT is reshaping the conversation around "mental energy" in supplements and beverages.
New Acute Clinical Data Redefines Non-Stim Mental Energy
The centerpiece of PLT's SupplySide presence was the announcement of a second clinical study on Zynamite S, completed in collaboration with innovation partner Nektium Pharma. The study examined whether a single 100mg dose could deliver measurable cognitive and mood benefits within hours.
Study Design and Methodology
Researchers recruited 88 healthy university students for a randomized, double-blind, placebo-controlled crossover trial. Each participant received both Zynamite S and placebo in separate sessions with a 7-day washout period between conditions. Assessments occurred at baseline, then at 30 minutes, 3 hours, and 5 hours post-supplementation.
Zynamite is PLT Health's Next-Gen Brain and Body Support Ingredient, harnessing the power of ≥60% mangiferin from mango leaf extract
The testing battery included validated cognitive assessments:
- Trail Making Tests measured cognitive speed and mental flexibility
- Stroop Color and Word Test evaluated cognitive flexibility and inhibitory control
- Digit Substitution Test assessed attention, working memory, and processing speed
- Profile of Mood States (POMS) tracked mood changes including total mood disturbances, tension, and depression
Rapid-Onset Benefits Across Multiple Domains
Compared to placebo, Zynamite S produced measurable improvements across cognitive performance, mood, and energy markers. The timeline of benefits revealed both immediate and sustained effects:
At 30 Minutes:
- Enhanced mood
- Reduced fatigue
At 3-5 Hours:
- Faster mental processing speed
- Improvements in complex task handling
- Enhanced mental flexibility
- Better executive function
Throughout the Testing Period:
- Stress and tension reduction during demanding cognitive tasks
- Greater resilience under cognitive load
- Improved overall mood balance
PLT Health Solutions' new Zynamite S research shows impressive cognitive benefits. This water-soluble mango leaf extract improves processing speed, cognitive flexibility, and mood with effects lasting up to 5 hours after just one dose.
According to Joe Weiss, Global Head of Brand Management for PLT Health Solutions, "This newest study of Zynamite S builds upon Nektium's previous research demonstrating efficacy in what scientists agree are the core components of 'mental energy': improved cognitive performance, cognitive adaptability, enhanced mood, and reduced fatigue. These results are shown to occur within minutes to hours. Zynamite S has the potential to redefine what we mean by mental energy in consumer products."
Dr. Laura López-Ríos, Product Development Director Research, Development & Innovation at Nektium, emphasized the study's focus on experiential benefits. "The results of this study certainly demonstrate that using Zynamite S is 'experiential.' This second study on Zynamite S within a single year validates and expands upon our previous findings and demonstrates our commitment to better understanding and communicating the benefits that are possible with our ingredients."
Zynamite S: Solving the Solubility Challenge
Part of PLT Health's Beverage-Stable Platform, Zynamite S addresses a critical formulation barrier for beverage developers. As a water-soluble form of award-winning Zynamite (a mango leaf extract standardized to ≥60% mangiferin), it enables confident inclusion in RTDs, shots, and other liquid delivery systems where taste, solubility, heat stability, and transparency matter.
The timing is strategic. Consumer demand for performance beverages continues accelerating, while concerns about high-caffeine formulas create opportunity for alternatives that deliver energy and focus without stimulant-related downsides. Zynamite S positions itself in this gap, offering what PLT calls "smarter energy" backed by clinical validation.
And what better way to demonstrate it than to put it into the show's official collab drink:
CREATEA Mighty Mango: Science Meets Consumer Experience
CREATEA Mighty Mango breaks new ground with stable creatine in RTD format plus Zynamite S mango leaf extract for mental energy. This natural, clean-label concept beverage showcases what's possible when industry leaders collaborate. Sample it at SupplySide Global 2025!
PLT gave SupplySide attendees a chance to experience Zynamite S firsthand through CREATEA Mighty Mango, a 12-ounce proof-of-concept RTD developed by a consortium of ingredient innovators, formulation experts, and marketing specialists. The project, spearheaded by PricePlow's very own Ben Kane, brought together multiple ingredient suppliers to demonstrate what's possible when innovation partners collaborate.
CREATEA was strategically distributed throughout SupplySide Global at PLT's booth and three separate lobby stations, maximizing exposure for the concept and its featured ingredients. The beverage served dual purposes: showcasing Zynamite S in a realistic consumer format while demonstrating the functional beverage category's potential.
Steve Fink, Vice President of Marketing for PLT, noted the significance of the expanded role: "SupplySide in Las Vegas is the premier destination for innovators in the supplements and functional food and beverage industries. The opportunity to become the official performance beverage sponsor at this event is an honor for all of us at PLT. We are looking forward to engaging the entire SupplySide community with our expanding beverage ingredient portfolio, some new science and some innovative ideas for formulating consumer products."
(For more on CREATEA's development, see our coverage: CREATEA Mighty Mango: The Next Generation of Collaborative Innovation at SupplySide Global 2025)
Thought Leadership: Presentations and Panel Discussions
PLT leveraged its sponsorship to create multiple educational touchpoints throughout the show.
Dr. Jeremy Appleton on Smarter Energy
On Thursday, October 30, Dr. Jeremy Appleton (PLT's Director of Medical and Scientific Affairs) joined Mai Nygaard (Nektium's Strategic Marketing Director) for "Smarter energy in action: Zynamite S and the future of cognitive performance" at the Product Development Theater. The 20-minute presentation walked attendees through the new clinical findings and explained how Zynamite S differentiates from traditional stimulants.
Dive into PLT Health's cognitive platform with Steve Fink and Dr. Jeremy Appleton, exploring Zynamite, Zembrin, and Vanizem's impact on brain health in Episode #146 of the PricePlow Podcast
The presentation emphasized three key benefit pillars:
- Enhanced cognitive performance beginning at 3 hours, including processing speed, focus, flexibility, and executive function
- Mood and energy benefits as early as 30 minutes, including reduced fatigue and greater resilience under cognitive demand
- Stress and tension reduction during demanding tasks, supporting calm composure while maintaining mental performance
Dr. Appleton framed Zynamite S as addressing a fundamental consumer tension: people want energy they can feel quickly, but without high-caffeine formulas' downsides. The ingredient's dual-phase benefit structure (rapid mood/energy onset followed by sustained cognitive support) offers formulators a way to deliver both immediate experiential effects and longer-term performance.
Dr. Appleton previously appeared on the PricePlow Podcast to discuss PLT's cognitive ingredient portfolio: PLT Health's Cognitive Ingredients: Enhance Focus, Mood, & Brain Health | Episode #146.
The Future of Formulating Beverages Panel
CREATEA also served as the focal point for "The Future of Formulating Beverages" panel discussion at the SupplySide Innovation Stage on October 29. Led by Ben Kane of PricePlow, the panel featured representatives from multiple ingredient suppliers, media, packaging, and marketing professionals who contributed to CREATEA's development.
The discussion explored challenges and opportunities in functional beverage formulation, using CREATEA as a case study for effective collaboration across the supply chain. The panel format allowed attendees to hear directly from innovators about practical considerations in beverage development, from ingredient selection and dosing to flavor masking and shelf stability.
Listen to the full panel discussion: The Future of Functional Beverages: CREATEA Panel at SupplySide Global 2025 | Episode #189.
Building on XPO NRG's Success
PricePlow is proud to announce XPO NRG, an industry-first collaborative energy drink exclusive to SupplySide West 2024. With 10 partners, we ran 50,000 cans at MacroCap Labs!
CREATEA represents PLT's second year participating in major collaborative beverage projects at SupplySide. In 2024, PLT contributed to XPO NRG, an industry-first collaborative energy drink that distributed thousands of cans throughout SupplySide West. The project established a model for supplier collaboration that CREATEA built upon and refined.
Strategic Direction: PLT's Beverage-Forward Future
PLT's elevated presence at SupplySide Global 2025 signals strategic commitment to the beverage category. The combination of official sponsorship, new clinical data on a beverage-optimized ingredient, collaborative product development, and educational programming creates a comprehensive narrative about where PLT is headed.
Weiss emphasized the solubility advantage: "The fact that Zynamite S is water-soluble makes the ingredient even more exciting because it can be formulated into delivery systems that represent significant growth areas in supplement and functional products markets."
The timing aligns with broader industry trends. Functional beverage categories continue expanding as consumers seek convenient, enjoyable delivery formats for health and performance benefits. Meanwhile, growing sophistication around caffeine consumption creates demand for alternatives that deliver mental energy without relying solely on stimulants.
Zynamite S positions itself at the intersection of these trends: a clinically validated cognitive ingredient with rapid-onset experiential benefits, formulated specifically for beverage applications. The SupplySide Global platform allowed PLT to demonstrate not just the ingredient's potential, but its practical application in realistic consumer products.
Conclusion: PLT Health Solutions Into The Future
PLT Health Solutions used SupplySide Global 2025 to advance multiple strategic objectives simultaneously. The new Zynamite S clinical data provides the scientific foundation. CREATEA Mighty Mango demonstrates practical application and consumer experience. The sponsorship and educational programming establish thought leadership in the functional beverage space.
Industry leaders from PLT Health Solutions, Glanbia Nutritionals, NNB Nutrition, NutriScience Innovations, and LaCore Nutraceuticals discuss the collaborative innovation behind CREATEA Mighty Mango at SupplySide Global 2025 on Episode #189 of the PricePlow Podcast.
For formulators considering Zynamite S, the value proposition is clear: a water-soluble cognitive ingredient with fast-acting mood and energy benefits (30 minutes) plus sustained cognitive performance support (3-5 hours), backed by randomized controlled trials using validated assessment tools. For an ingredient category often plagued by proprietary blends and questionable evidence, Zynamite S offers transparency and clinical rigor.
The ingredient's ability to deliver both immediate experiential effects and measurable cognitive improvements creates formulation flexibility. Brands can position products for morning focus, afternoon energy slumps, pre-workout mental preparation, or sustained productivity support throughout the workday.
As the functional beverage category continues maturing, ingredients like Zynamite S that solve both formulation challenges (solubility, taste, stability) and consumer needs (effective, fast-acting, non-stimulant energy) become increasingly valuable. PLT's SupplySide Global 2025 presence demonstrated not just what Zynamite S can do, but how collaborative innovation across the supply chain can accelerate category growth.
To learn more about Zynamite S and PLT's expanding beverage ingredient portfolio, visit www.plthealth.com/zynamite.
Comments and Discussion (Powered by the PricePlow Forum)