PLT Health Solutions’ new Zynamite S research shows impressive cognitive benefits. This water-soluble mango leaf extract improves processing speed, cognitive flexibility, and mood with effects lasting up to 5 hours after just one dose.
In the evolving landscape of nootropic supplements, innovation isn’t just about discovering new compounds – it’s also about making existing powerhouses more accessible and versatile. PLT Health Solutions has just announced promising new research on Zynamite S, a water-soluble version of their award-winning mango leaf extract that delivers impressive cognitive benefits in a single dose.[1]
The latest study, conducted on 120 healthy university students, demonstrates that Zynamite S significantly improves processing speed, cognitive flexibility, and mood with effects lasting up to 5 hours after just one dose. More importantly, this new water-soluble form opens doors for beverage applications that weren’t previously possible.
Zynamite S is a part of PLT Health’s Beverage-Stable Platform, and we’re confident we’ll be seeing it in sports and active nutrition beverages in the coming year — especially with this new forthcoming data. This article explains what we know, but before we get into it, get signed up for our PLT Health and Zynamite news alerts and let’s get a recap on Zynamite itself:
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What is Zynamite? A Brief Refresher on This Botanical Powerhouse
For those who haven’t been following our coverage, Zynamite is a patented, proprietary extract from mango leaves (Mangifera indica) standardized to contain at least 60% mangiferin, a naturally-occurring xanthone polyphenol. Since its introduction, Zynamite has accumulated an impressive collection of research supporting its benefits for both cognitive function and physical performance.[2]
What makes the Zynamite family so valuable in the sports nutrition space is its non-stimulatory nature. Unlike caffeine, Zynamite can enhance mental energy and focus without increasing heart rate or blood pressure, making it an excellent alternative for those sensitive to stimulants.[2]
The Three Versions of Zynamite
PLT Health has developed three distinct versions of this ingredient:
- Zynamite – The original extract primarily used in capsules, tablets, and powder formulations
- Zynamite PX – A combination of Zynamite with Sophora japonica (standardized to quercetin), specifically formulated for sports performance and recovery
- Zynamite S – The newest innovation, a water-soluble form designed for beverage applications, but also applicable to powders seeking better taste and mixability
Introducing Zynamite S: A Soluble Solution for Beverage Formulations
The newest member of the Zynamite family addresses a common formulation challenge with botanical extracts – poor solubility and complex taste profiles in liquid applications. Zynamite S represents a significant technological breakthrough that makes this clinically-validated ingredient accessible to beverage and powder manufacturers.
Key advantages of Zynamite S include:
- Enhanced water solubility for clear solutions in beverages
- Neutral taste profile for easier formulation
- Heat stability for various manufacturing processes
- Approximately 3x greater bioavailability than standard Zynamite
- Effective at lower doses (100 mg vs 300 mg for the standard extract)
This comprehensive infographic showcases why Zynamite S represents a major breakthrough for beverage applications. The water-soluble, neutral-tasting formulation delivers three times greater bioavailability than standard Zynamite, enabling effective dosing at just 100mg for cognitive benefits and 47mg for sports performance when combined with quercetin. The innovative nature of this ingredient opens possibilities for clear, great-tasting functional beverages with fast-acting mental energy benefits.
This advancement allows formulators to incorporate Zynamite into ready-to-drink (RTD) beverages, shots, and other liquid applications where traditional botanical extracts would present challenges.
This elegant diagram illustrates the interconnected benefits that make Zynamite S a game-changer for supplement developers. The four key advantages – enhanced solubility, improved bioavailability, better taste profile, and lower effective dosing – work together to create a truly versatile ingredient. The clean, simple visual effectively communicates why formulators should consider Zynamite S for their next-generation cognitive and performance products.
The New Zynamite S Clinical Study: Design and Methodology
PLT Health Solutions’ research partner, Nektium Pharma, recently sponsored a comprehensive clinical trial examining the cognitive effects of Zynamite S.[1] This study represents a significant addition to the already impressive research portfolio supporting the Zynamite family of ingredients.
The clinical trial utilized a rigorous methodology:[1]
Zynamite is PLT Health’s Next-Gen Brain and Body Support Ingredient, harnessing the power of ≥60% mangiferin from mango leaf extract
- Participants: 120 healthy university students (aged 18-21)
- Design: Randomized, double-blind, placebo-controlled crossover with 7-day washout periods
- Dosing: Single dose of either 100 mg Zynamite S, 150 mg Zynamite S, or placebo
- Assessment Times: Baseline, 30 minutes, 3 hours, and 5 hours post-consumption
- Cognitive Tests: Trail Making Tests (A & B), Stroop Color and Word Test, Digit Symbol Substitution Test, Rey’s Auditory Verbal Learning Test
- Mood Assessment: Profile of Mood States (POMS)
Impressive Results: Cognitive Enhancement from a Single Dose
The study results reveal that Zynamite S delivers significant cognitive benefits after just one dose, with effects lasting up to 5 hours.[1] These improvements were measured across multiple dimensions of cognitive performance.
Enhanced Mental Processing Speed and Cognitive Flexibility
Participants taking Zynamite S showed significant improvements in their ability to process information quickly and efficiently:[1]
- >9% improvement in processing speed (Trail Making Test A)
- >5% improvement in handling complex tasks (Trail Making Test B)
- >11% improvement in attention and working memory (Digit Symbol Substitution Test)
Processing speed matters for cognitive performance, and this graph clearly shows how participants taking Zynamite S completed the Trail Making Test A significantly faster than those on placebo. The data reveals approximately 9% improvement in mental processing speed, with benefits lasting a full 5 hours after a single dose – impressive longevity for a non-stimulant cognitive enhancer.
This graph illustrates how Zynamite S enhances complex cognitive tasks requiring mental flexibility. The more challenging Trail Making Test B measures task-switching ability – a critical executive function skill. Both dosages of Zynamite S significantly outperformed placebo at the 5-hour mark, demonstrating the ingredient’s lasting impact on higher-order thinking processes without the crash associated with traditional stimulants.
The Digit Symbol Substitution Test reveals Zynamite S’s powerful effects on attention and working memory. Participants taking 100mg of Zynamite S showed superior performance throughout the testing period, achieving up to 11% improvement compared to placebo. This graph highlights the ingredient’s ability to support sustained mental performance – a key benefit for students, professionals, and anyone requiring optimal cognitive function.
These improvements were statistically significant compared to placebo and began as early as 30 minutes after consumption, with benefits continuing throughout the 5-hour testing period.
Mood Enhancement and Reduced Tension
Beyond cognitive performance, Zynamite S also demonstrated meaningful effects on mood states:[1]
- Up to 30% improvement in overall mood
- 41% reduction in tension
- 43% improvement in clarity of thought
This detailed breakdown summarizes the impressive clinical results achieved with just one dose of Zynamite S. The left panel highlights the experiential benefits, including a 9% boost in processing speed and up to 30% improvement in overall mood. The right panel provides more granular data on specific cognitive and emotional benefits at different dosages, demonstrating Zynamite S’s comprehensive impact on mental performance and emotional well-being.
These mood benefits are particularly meaningful as they address the emotional component of cognitive performance – helping users feel more composed and clear-headed while tackling complex tasks.
How Zynamite S Works: COMT Inhibition Without Stimulation
What makes Zynamite’s mechanisms particularly interesting is how it differs from traditional stimulants. Research suggests that mangiferin, the primary bioactive in Zynamite, functions as a selective inhibitor of catechol-O-methyltransferase (COMT).[3]
PLT Health Solutions: Growth Through Innovation
COMT is an enzyme responsible for breaking down catecholamine neurotransmitters like dopamine, particularly in the prefrontal cortex. By inhibiting this enzyme, Zynamite may help maintain higher levels of dopamine in key brain regions associated with executive function and working memory.[3]
Crucially, unlike caffeine, Zynamite achieves these effects without affecting cardiovascular parameters. Multiple studies have confirmed that Zynamite intake does not significantly impact heart rate, blood pressure, or heart rate variability – making it truly “non-stim”.[2]
Beyond Cognition: The Physical Performance Benefits of Zynamite PX
While this new study focuses on the cognitive benefits of Zynamite S, it’s worth noting that the Zynamite PX formulation (which combines Zynamite with Sophora japonica) has also shown impressive benefits for physical performance in athletes.
Research on Zynamite PX has demonstrated:[4]
Stability is crucial for beverage applications, and this data confirms Zynamite S passes rigorous testing with flying colors. The graphs demonstrate mangiferin’s stability across different pH levels and thermal processing conditions, including boiling for extended periods. This remarkable stability makes Zynamite S particularly valuable for RTD beverage manufacturers, ensuring the active compound remains potent throughout shelf life despite various manufacturing processes.
- 3.8% increased peak power output after just one dose
- Reduced blood lactate levels during exercise
- Accelerated recovery from intense workouts
- Improved athletic performance in basketball players
These physical performance benefits make Zynamite a true “brain and body” ingredient – something increasingly sought after by consumers looking for comprehensive performance support.
Formulation Recommendations and Applications
Based on the clinical research, PLT Health provides the following dosage recommendations:
- For cognitive applications:
- 300 mg of standard Zynamite, or
- 100 mg or 150 mg of Zynamite S
- For sports performance applications:
- 420 mg Zynamite PX (140 mg Zynamite + 280 mg Sophora japonica [50% quercetin]), or
- 46.7 mg Zynamite S + 280 mg Sophora japonica [50% quercetin]
The enhanced bioavailability of Zynamite S makes it approximately 3x more potent than standard Zynamite, allowing for significantly lower dosages while maintaining efficacy.
This scientific slide details the impressive pharmacokinetic advantages of Zynamite S over regular Zynamite. The graphs visualize how mangiferin from Zynamite S reaches significantly higher blood concentration levels – up to 3.25 times higher within the first two hours after consumption. This enhanced bioavailability explains why lower doses can deliver powerful cognitive benefits, making the ingredient more cost-effective and suitable for beverage applications.
Marketing and Consumer Positioning
The new Zynamite S formulation opens opportunities for product developers to target various consumer segments:
- Students seeking improved focus and cognitive flexibility during studies
- Working professionals needing sustained mental energy without the jitters
- Athletes looking for both mental and physical performance enhancement
- Gamers requiring quick reaction times and mental stamina
- General wellness consumers interested in mental clarity and mood support
The fast-acting, experiential nature of Zynamite’s benefits makes it particularly appealing in today’s market where consumers expect to “feel” their supplements working.
This comprehensive market positioning wheel showcases the remarkable versatility of the Zynamite ingredient family. The diagram illustrates how the three versions – standard Zynamite, Zynamite PX, and Zynamite S – can be incorporated into numerous product categories spanning both caffeine-containing and caffeine-free formulations. From cognitive performance to sports nutrition, the wheel demonstrates how Zynamite offers formulators incredible flexibility to create targeted solutions for diverse consumer needs.
You can learn more about the Zynamite platform in our article titled “Zynamite: Next-Generation Brain and Body Support from Mangiferin“.
Conclusion: A Game-Changing Ingredient Gets Even Better
Zynamite already stood out as one of the most impressive botanical ingredients for cognitive and physical performance enhancement. The new water-soluble Zynamite S formulation removes the barriers to liquid applications or tricky powder supplements, while delivering impressive cognitive benefits at a lower dose.
Are you ready for a shake-up in the beverage space? PLT Health Solutions has worked hard to create several beverage-stable ingredients, so that we can avoid all of the me-too RTD formulas.
The clinical validation of Zynamite S further strengthens PLT Health’s position as a leader in evidence-based functional ingredients. With benefits spanning mental energy, cognitive performance, mood enhancement, and physical performance, the Zynamite family represents a comprehensive solution for today’s performance-focused consumers.
As beverage formulators now have access to this impressive ingredient, we expect to see Zynamite S appearing in a wide range of functional beverages and shots in the coming months. Stay tuned to PricePlow for coverage of new product launches featuring this innovative ingredient.
This article will be updated with the full journal publication of the new Zynamite S study.
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