nooLVL: A Next-Generation Nootropic Focus Ingredient

nooLVL is a dietary supplement ingredient from Nutrition21 that has a clinical study supporting its use on gamers — who were playing modern games in the research trial!

Our world is one with an ever-shifting limelight – various things come and go, each capturing facets of attention for small periods of time.


nooLVL is a new ingredient from Nutrition21 that is the first to have a clinical study on it specifically performed on gamers — who were playing modern games!

We’ve seen a variety of trends gain significant traction in multiple sectors. In the supplement industry, we’ve witnessed the popularity of vegan products and nootropics grow exponentially. In parallel, we have the boom of eSports. Electronic gaming is among the fastest-growing businesses in the world, and more people are beginning to take notice.

One of the most interesting developments in regards to eSports has been the increasing demand for focused-based eSport supplements. These products are designed to increase cognition and mental quickness to improve one’s performance in gaming. This rise in demand has bred heaps of innovation as well, with companies continuously searching for the next best thing in the market. Gaming supplements are on the rise!

The first fully-dosed nooLVL Supplements like Ghost Gamer are here!

Ghost Gamer Sour Patch Kids

Be on the top of your game with Ghost Gamer.

2019 saw the release of the world’s first clinically-dosed gaming supplements such as Advanced.GG’s Focus 2.0 and Ghost Gamer. With feel-good focus formulas and incredible flavors, these industry leaders have built incredible followings, and for good reason: they work. Whether you compete in eSports or are just a recreational gamer, Ghost Gamer is formula you should look into!

Both Ghost Gamer and Focus V2 utilize nooLVL, the world’s first science-backed nutritional supplement for gamers. This patented non-stimulant is the latest step taken towards the future of focus supplements, and can seriously take cognition to another level, especially for gamers!

In this post, we’ll tell you all about nooLVL and why its inclusion in Gamer and Focus V2 are so effective. Before we get into them, make sure you’re subscribed to PricePlow for some of the best supplement deals, news, reviews, and interviews out there!

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Watch as you read with our explainer video below, and then we get into the details after that:

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Powerful gaming supplements powered by nooLVL

Top brands like Ghost and wouldn’t have bothered releasing a new supplement had they not been confident it would be superior to competition!


Nutrition21, the creators of nooLVL, provided materials for this article

What’s different than the standard old energy drinks used by everyone else? The key driver is nooLVL, a patented ingredient from the bright minds at Nutrition21, one of the world’s leading ingredient developers. nooLVL is itself an advancement of a well-known cognitive booster, engineered to deliver a higher level of results.

This ingredient is also the first cognitive booster explicitly tested on gamers, where it passed with flying colors. If gaming is your thing, nooLVL is something you’ll like want in your arsenal come game-time. Even if you don’t play video games, if your work or hobbies call for enhanced reaction time, processing speed, and energy, this novel ingredient can be beneficial!

What is nooLVL?

Nitrosigine Arginine Inositol Silicate

Not only does Nitrosigine immediately boost N.O. levels, it keeps them elevated for a period of up to 2 weeks!
Image courtesy of

A further iteration of one of the industry’s most popular compounds, nooLVL is an advanced version of their powerhouse nitric oxide boosting ingredient, Nitrosigine. This is comprised of bonded arginine silicate with inositol, but in the case of nooLVL, there’s even more inositol! This provides improved blood flow to the brain, and then delivers a powerful nutrient that helps it work better.

Let’s dive a bit deeper into each component:

  • Arginine silicate

    If you’re at all familiar with supplements, you’ve likely heard of L-arginine before. This amino acid was one of the industry’s first “nitric oxide pump”-inducing ingredients, showing the ability to increase blood flow via increased nitric oxide (NO) production.[1] Given that the body breaks arginine down into nitric oxide directly,[2] it helps encourage improved blood flow, which led athletes and weightlifters to use it to improve performance and get the much-heralded muscle “pump” when training.

    Nutrition21 Nitrosigine Graphic

    Nitrosigine is what we always wanted L-arginine to be. It took the innovative researchers at Nutrition21 to make it a reality. Now that we have the blood flow, can we use it to deliver more focus?

    However, we quickly learned that plain L-arginine was not the best advocate for enhanced NO synthase, as it unfortunately holds poor bioavailability in isolation. We needed something better, it just didn’t work well enough on its own since it got broken down too quickly. However, science has shown that bonding it to silica (making arginine silicate) and combining it with inositol can significantly increase NO production and energy levels.[3] This tandem makes for an effective hit of blood flow, focus, and energy, bioavailability be damned!

    So Nutrition21 developed this ingredient as Nitrosigine, and it became the arginine that we had always wanted – one that clinically improved blood flow, nitric oxide levels, and workouts like L-arginine had been theorized decades ago.

    Blood flow is great for athletes, but now it’s time to make it better for the e-athletes:

  • Inositol – a higher dose than usual!

    Inositol is a sugar that the body relies on to facilitate a number of functions. From maintaining cell membranes to promoting neurotransmitter activity,[4,5] inositol is a vital part of everyday life, though it often goes unnoticed.


    Inositol is a beautiful carbocyclic sugar that is abundant in brain, and amongst other tasks, it mediates cell signal transduction in response to a variety of neurotransmitters. Image courtesy Wikimedia.

    Research has begun to show just how influential this sugar can be, however, specifically in regards to mental health. Multiple studies have found high correlations between things such as depression and low levels of inositol in the brain, suggesting that this sugar is key for neurotransmitter activation.[6] Furthermore, inositol supplementation has shown the ability to balance brain-based chemical production, improving levels of key neurotransmitters such as dopamine and serotonin.[5] This brain-boosting sugar has quite the effect on your cognition.

    What’s special here is that nooLVL uses more inositol than the athletically-minded arginine silicate inositol blend in Nitrosogine! This enables it to have more of a cognitive effect, making it all the more relevant in the world of gaming.

    This ingredient delivers some powerful brain-boosting NO-powered blood flow, the exact type of thing necessary to enhance brain power a bit! Luckily, the benefits yielded by this NO boost have been researched, notably in professional gamers.

The first clinical cognitive-boosting gaming ingredient!

There are many cognitive-enhancing ingredients and stimulants – some safer and more legal than others. However, once nooLVL is both of those, and was researched specifically on gamers!

nooLVL Research 1: TMT-A Time

TMT-A is a test where the subject is asked to connect an ascending sequence of 25 numbers as quickly as possible. An improvement indicates enhanced motor and visual search speed. Image courtesy Nutrition21.

In research published in October 2019, the cognitive effects of the new ingredient, nooLVL, was tested in eSport athletes. In a double-blind, placebo-controlled study, 60 subjects were randomly assigned to two groups – one was administered 1600g of nooLVL daily for seven days, with the other group receiving a placebo.[7]

In order to test the ingredient’s effects, multiple tests were conducted – Trail Making Test A and B (TMT-A,B), Stroop Test, Profile of Mood States (POMS), and ultimately, video game performance – in real games that matter in 2019.

In the TMT-A,B tests, the test group performed significantly better after just 15 minutes of supplementation and 60 minutes of gaming, completing the tests faster and with less errors.[7] A similar faster completion speed was found in the Stroop Test as well, with the POMS test unveiling higher scores of self-reported energy in the nooLVL group.[7]

The study found that both groups improved in video game performance, with no significant differences identified between the two. That being said, the cognitive effects are impressive, with nooLVL displaying its potential in this study.

A 2019 study using 2019 games

nooLVL Research Stroop Test

The Stroop test is a neurocognitive test where subjects must read aloud the color of the text that is printed rather than the actual text! It evaluates selective attention, response inhibition, and reaction time. Fewer errors are better!

It’s also worth noting that the games tested were amongst today’s most popular, including Fortnite, Call of Duty, and Madden. Although these effects should translate to most video games, if you’re serious about online play in any of the games from this study, nooLVL has already shown to promote better play!

New 2021 Data: Improved Short-Term Memory and Reaction Time

In mid-2021, a team of researchers at the Texas A&M University shared incredible new findings on nooLVL at the 2021 ISSN (International Society of Sports Nutrition) conference, demonstrating different benefits compared to those discussed above.[8] Their study was subsequently published in Nutrients.[9]

Whereas the original study discussed above showed improvements over the span of seven days, this Nutrition21-sponsored double-blinded, placebo-controlled, crossover study showed that nooLVL can provide short-term memory and reaction time improvements as well![8,9]

The study is covered in greater depth in our article titled nooLVL Increases Short-term Memory and Reaction Time: New Study, and further updates will be made when it is published. The poster presentation can be seen below:

nooLVL Short-Term Memory & Reaction Time 2021 ISSN Poster

The full poster from the Texas A&M team, as presented at the 2021 ISSN Conference.[8,9]

New 2022 Data: Improved Attention, Concentration, Visual Representation, and Spatial Planning

In early 2022, Nutrition21’s researchers gave a poster presentation at the prestigious Experimental Biology conference, showing their most recent findings in healthy young adult gamers (both men and women) using nooLVL.[10] They found that nooLVL helped improve scores on tests for attention and concentration, visual representation, and spatial planning, sometimes after a single use:

nooLVL Gamers 2022 Data

nooLVL helped gamers improve scores on tests for attention and concentration, visual representation, and spatial planning, sometimes after a single use.[10]

These skills are all incredibly useful for fast-paced games that are popular in the gaming community.

The presentation is discussed in detail in our article titled New nooLVL Nootropic Data Previewed: More Benefits for Gamers!, and will be updated when the paper is published in a peer-reviewed journal.

The future of gaming / esports supplements – what to expect?

nooLVL is often paired with additional ingredients to improve energy, cognition, stamina, and even eye health.


nooLVL is the anchor in the industry’s newest top-tier gaming supplements.

We often see ingredients that add choline sources for the brain and protect them, such as Alpha-GPC or Citicoline. Energy comes in the form of caffeine, but for gamers, we’re noticing that slow and fast-acting caffeine blends are hugely popular, so that the effect lasts longer. The caffeine is often synergistic with L-theanine or Rhodiola. And finally, ingredients like lutein and zeaxanthin are popular for eye support.

There are plenty of other great synergistic ingredients, and the point is that they provide much more than the typical energy drinks or energy powders wrongly tagged as “supplements”. nooLVL is a true gaming ingredient, designed and tested specifically for gamers. Not much else out there can say that!

Conclusion – reach another level thanks to nooLVL

Ghost Gamer Sour Patch Kids Redberry

Fronted by Nutrition21’s nooLVL, Ghost Gamer can help you take your skills to the next level!

Video games originally came to us as a form of recreation – an entertaining way to spend time as kids or a way for adults to destress after long days at school or at work. Their origin is not all that much different from popular sports such as baseball – the first baseball players played for fun, only to later realize they could compete and monetize their talents. Following a similar trajectory, recreational gaming has led to eSports – competitive gaming filled with e-athletes looking for ways to improve their abilities in order to find more success.

Ghost and Advanced.GG are in a growing population of supplement brands focused on the gaming community, and they’re doing it right. Gaming supplements are often structured to increase energy levels and improve cognitive ability, particularly in terms of reaction speed and accuracy. But in the sea of “nootropic” ingredients, Nutrition21’s nooLVL is the one that’s actually tested on real gamers playing modern games.

nooLVL is ready to storm the arena

nooLVLelevates brain power via two avenues – enhanced oxygenated blood flow and increased neurotransmitter levels. Translation – it delivers more energy, more focus, and quicker response times!

Advanced.GG Focus 2.0 and Ghost Gamer are potent supplements, and the brands are excited to share them with the world. They just may be able to take your gaming to the next level!

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Note: This article was originally published in October of 2019 and updated April 2022 with the latest data.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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  1. Barassi, A., et al; “Levels of l‐Arginine and l‐Citrulline in Patients with Erectile Dysfunction of Different Etiology.”; Wiley Online Library; John Wiley & Sons, Ltd (10.1111); 8 Feb. 2017;
  2. Wu, G, and S M Morris Jr; “Arginine metabolism: nitric oxide and beyond.”; The Biochemical journal; vol. 336; Pt 1; 1998; 1-17;
  3. Komorowski1, J; “The Benefits of Inositol-Stabilized Arginine Silicate as a Workout Ingredient.”; Journal of the International Society of Sports Nutrition, BioMed Central; 21 Sept. 2015;
  4. Michell, R H; “Inositol Phospholipids and Cell Surface Receptor Function.”; Biochimica Et Biophysica Acta; U.S. National Library of Medicine; 25 Mar. 1975;
  5. Levine, J; “Controlled Trials of Inositol in Psychiatry.”; European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology; U.S. National Library of Medicine; May 1997;
  6. Barkai, A I, et al; “Reduced Myo-Inositol Levels in Cerebrospinal Fluid from Patients with Affective Disorder.”; Biological Psychiatry; U.S. National Library of Medicine; Feb. 1978;
  7. Tartar, J. L., et al; “A Prospective Study Evaluating the Effects of a Nutritional Supplement Intervention on Cognition, Mood States, and Mental Performance in Video Gamers.”; Nutrients – MDPI Open Access Journals; 11, 2326; Oct. 1, 2019;
  8. Gonzalez, D, et al; “Effects of Arginine Silicate and Inositol Ingestion on Cognitive and Executive Function in Gamers”; International Society of Sports Nutrition; ISSN 2021 Presentation Poster; 2021;
  9. Sowinski, Ryan, et al. “Effects of Inositol-Enhanced Bonded Arginine Silicate Ingestion on Cognitive and Executive Function in Gamers.” Nutrients, vol. 13, no. 11, 1 Nov. 2021, p. 3758, 10.3390/nu13113758;
  10. Emerson, Katie, et al; “Effects of a Bonded Arginine Silicate Inositol Combination (nooLVL) on Cognitive Function in eSports Gamers”; Experimental Biology 2022; Poster Presentation; April 8, 2022;

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