Musclesport Pre Lean: A Thermogenic Pre-Workout Revolution

Published on February 28, 2025 by PricePlow Staff | No Comments
Musclesport Pre Lean: A Thermogenic Pre-Workout Revolution

Musclesport is launching Pre Lean at the 2025 Arnold Sports Festival. This innovative pre-workout combines training performance with thermogenic ingredients – perfect for those wanting effective workouts while supporting fat loss goals.

Musclesport, the brand that revolutionized protein powders with their Lean Whey series, is ready to shake up their pre-workout menu with Pre Lean – a comprehensive thermogenic pre-workout supplement launching at the 2025 Arnold Sports Festival.

Pre Lean combines intense training support with advanced fat-metabolizing ingredients — a solid parallel to the Lean Whey linked above. While most pre-workouts focus solely on energy and pumps, Pre Lean adds an extra dimension by incorporating studied thermogenic compounds that can help users achieve their body composition goals.

Musclesport Pre Lean: The “Lean Whey” of Pre-Workouts

The formula brings together four distinct complexes: a pump-boosting blend for muscle fullness, proven performance enhancers for strength and endurance, an innovative thermogenic matrix that mirrors the success of Lean Whey’s fat-metabolizing system, and an energizing component that supports focus and motivation (yielding 300mg caffeine total). This strategic combination allows users to train harder while simultaneously supporting their fat loss efforts.

With the inclusion of premium ingredients like ProGBB, CapsiAtra, and a dual-carnitine complex, Pre Lean demonstrates Musclesport’s continued commitment to using cutting-edge compounds that deliver real results. These aren’t just “buzz ingredients” – they’re research-backed additions that complement the foundational pre-workout elements athletes expect.

Check prices and availability on Pre Lean below, sign up for our Musclesport news alerts to get notified about this and other launches, and then let’s get into the science:

Musclesport Pre Lean – Deals and Price Drop Alerts

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Musclesport Pre Lean Ingredients

One scoop (15.5 grams) of Pre Lean provides the following:

Muscle Hardness & Pump Complex

The foundation of any great pre-workout supplement starts with ingredients that enhance blood flow and muscle volumization. Pre Lean’s Muscle Hardness & Pump Complex combines proven nitric oxide boosters with hydration and blood sugar shuttling support to maximize training-induced muscle fullness while providing sustained vasodilation throughout your workout.

Musclesport Pre Lean Ballistic Black Cherry Ingredients

  • L-Citrulline – 4000mg

    L-citrulline is an amino acid that serves as a highly effective precursor to L-arginine and nitric oxide production.[1] Unlike direct L-arginine supplementation, L-citrulline bypasses first-pass metabolism in the liver, making it a more efficient way to boost blood arginine levels and enhance nitric oxide production.[2]

    At a clinically-supported dose of 4 grams, L-citrulline can significantly increase plasma arginine concentrations, leading to improved blood flow and muscle pumps during exercise.[3] Research shows that L-citrulline supplementation may enhance exercise performance by reducing fatigue and improving oxygen utilization.[4]

    While the pump-enhancing effects are most noticeable during resistance training, L-citrulline’s benefits extend beyond just cosmetic muscle fullness. The increased blood flow can support faster recovery between sets and enhanced nutrient delivery to working muscles.[5]

    Pre Lean’s 4-gram dose sits right at the research-validated clinical threshold, providing users with an effective dose that can reliably enhance pumps and performance when combined with the formula’s other vasodilating ingredients.

  • Taurine – 500mg

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    Taurine is a conditionally essential amino acid that serves multiple functions in exercise performance, with important roles in muscle function and hydration. While many pre-workouts include 1-2g doses, the 500mg here still provides meaningful benefits when combined with Pre Lean’s other ingredients.

    In muscle tissue, taurine helps regulate calcium ion dependent excitation-contraction coupling and cellular volume, which supports muscle function during intense training.[6] Its cell-volumizing properties complement the pump-enhancing effects of citrulline in this formula.

    Research has shown that taurine can enhance endurance performance and reduce oxidative stress from exercise, with benefits seen from doses ranging from 500mg to 6g.[7] When combined with caffeine, as it is in Pre Lean, taurine may help smooth out the stimulant effects while maintaining proper hydration status during intense training sessions.[8]

    Most pre-workouts have the above two ingredients, but not this next one:

  • Vanadyl Sulfate – 10mg

    Vanadyl sulfate is an intriguing ingredient that sits at the intersection of blood glucose management and muscle fullness. This mineral supplement has shown promise in supporting insulin sensitivity and glucose uptake into muscle tissue.[9]

    Musclesport Pre Lean

    At 10mg, Pre Lean provides a reasonable dose that can support workout performance without overdoing it. Research suggests that vanadyl sulfate may help shuttle glucose and nutrients into muscle tissue by mimicking insulin’s actions.[10]

    While most studies focus on vanadyl’s effects on blood sugar control, its ability to enhance glucose uptake into muscles[11] during training may contribute to better pumps and fullness. This effect complements the formula’s other pump ingredients like citrulline.

    The 10mg dose strikes a smart balance – enough to provide benefits while staying well below doses that could cause unwanted effects. Combined with Pre Lean’s other glucose-disposal ingredients, vanadyl sulfate helps create optimal conditions for muscle fullness during training while supporting efficient energy utilization.

Performance & Strength Complex

This complex contains two research-backed ingredients that support enhanced exercise performance and muscular endurance. With clinical doses of both beta-alanine and betaine anhydrous, Pre Lean provides the foundation needed for harder training sessions and better results.

  • Beta Alanine – 3200mg

    Beta-alanine is an amino acid that serves as the rate-limiting precursor to carnosine synthesis in skeletal muscle.[12] When supplemented consistently, beta-alanine increases muscle carnosine levels, which acts as an important intracellular pH buffer during high-intensity exercise.[13]

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    Research shows that 4-6g of daily beta-alanine supplementation can increase muscle carnosine concentrations by up to 64% after 4 weeks, leading to improved exercise performance in activities lasting 1-4 minutes.[14] The 3.2g dose in Pre Lean is right in line with research-backed dosing protocols, though you’ll want to supplement additional beta-alanine to reach optimal daily doses.

    Users may experience harmless tingling sensations (paresthesia) when taking beta-alanine, especially if they’re new to it. This sensation typically subsides within 60-90 minutes and can be minimized by splitting doses throughout the day.[14]

    With its clinically-supported benefits for high-intensity exercise capacity and fatigue resistance, beta-alanine is a core ingredient for anyone looking to maximize their training performance.

  • Trimethylglycine (Betaine Anhydrous 98%) – 1500mg

    Betaine, also known as trimethylglycine, continues to impress researchers with its diverse array of performance benefits. While Pre Lean’s 1.5g dose is slightly below the most frequently studied 2.5g amount, it still provides meaningful effects when combined with the formula’s other ingredients.

    As an osmolyte, betaine helps maintain cellular hydration and protein stability during intense exercise.[15] This leads to improved muscular endurance, as demonstrated in a 2018 study where betaine supplementation enabled athletes to perform significantly more repetitions during both bench press and leg press exercises. But even better than that, the study showed incredible body composition effects in women – but at that higher dose.[16]

    MuscleSport Amino + Hydration

    Beyond its role in muscle performance, betaine acts as a methyl donor that supports creatine production and fat metabolism.[17,18] Recent research has shown that betaine can enhance the testosterone response to resistance training while reducing cortisol levels – a favorable hormone profile for both performance and fat loss.[19]

    When combined with Pre Lean’s other metabolic enhancers like carnitine and ProGBB, betaine helps create an environment conducive to both high-intensity training and fat burning. This dual-action benefit makes it an excellent addition to this thermogenic pre-workout formula.

    And on that note, we now get into the thermogenic ingredient section:

Thermogenic Fat Metabolizing Matrix

Pre Lean’s thermogenic complex combines classic fat-burning ingredients with cutting-edge compounds to support metabolic enhancement during training. This matrix strategically pairs dual-form carnitine with ProGBB (a thermogenic carnitine-boosting compound) and CapsiAtra to create a comprehensive approach to fat metabolism and thermal energy production.

  • Carnitine Complex (L-Carnitine Tartrate, Acetyl L-Carnitine) – 1500mg

    Pre Lean utilizes a dual-carnitine approach, combining L-carnitine L-tartrate (LCLT) for performance benefits with acetyl L-carnitine (ALCAR) for enhanced bioavailability and cognitive support. L-carnitine plays a crucial role in fatty acid metabolism by shuttling long-chain fatty acids into the mitochondria where they can be oxidized for energy.[20]

    MuscleSport Carnishred + MitoBurn

    During high-intensity exercise, L-carnitine helps buffer metabolic stress and reduce markers of muscle damage, supporting faster recovery.[21] The L-tartrate form in particular has been shown to enhance recovery by reducing exercise-induced muscle tissue damage and soreness.[22]

    Meanwhile, ALCAR contributes additional benefits including enhanced mental focus and improved fat oxidation.[23] At 1500mg total, this complex provides an effective dose that can support both performance and fat-burning goals when combined with proper training and nutrition.

  • ProGBB (Gamma-butyrobetaine Ethyl Ester Chloride) – 20mg

    Pre Lean includes 20mg of ProGBB, a strategic dose of gamma-butyrobetaine (GBB) in its ethyl ester chloride form. GBB is a fascinating compound that serves as a direct precursor to L-carnitine in the body.[24] This makes it an excellent complement to the formula’s dual-carnitine complex discussed above.

    What makes GBB interesting is its effect on the body’s carnitine status. When consumed, it can increase carnitine production significantly more than other precursors.[25] With this increased carnitine production often comes a warming sensation that many users enjoy during their workouts.

    Musclesport Pre Lean Jungle Juice

    At 20mg, Pre Lean provides an effective yet reasonable dose that shouldn’t overwhelm new users – especially when starting with the recommended half-scoop. This is important since GBB can increase sweating,[26] so make sure to stay well-hydrated during your training sessions.[27]

    Combined with the formula’s carnitine complex, this ingredient helps round out Pre Lean’s comprehensive approach to supporting both training performance and metabolic enhancement.

  • CapsiAtra (Dihydrocapsiate) – 1.5mg

    CapsiAtra is a non-pungent capsaicin analog that provides the thermogenic benefits of hot peppers without the spicy sensation. This novel compound, also known as dihydrocapsiate, is naturally found in CH-19 Sweet peppers and has been synthesized for supplement use.[28]

    Research demonstrates that dihydrocapsiate can enhance energy expenditure and fat oxidation, particularly in individuals with higher BMI scores.[29] These effects appear to be mediated through activation of the sympathetic nervous system, similar to capsaicin but without its gastrointestinal side effects.[30]

    When combined with exercise, dihydrocapsiate may help increase endurance capacity by promoting fat utilization and sparing muscle glycogen.[31] This makes it a smart addition to Pre Lean’s thermogenic matrix, where it works synergistically with other metabolic enhancers like ProGBB and carnitine.

    While the 1.5mg dose might seem small, research shows that doses as low as 3mg daily can provide meaningful metabolic benefits when used consistently.[32]

Energizing Euphoria Matrix

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Pre Lean’s stimulant blend goes beyond just raw energy, combining traditional and novel ingredients to create an experience that’s both powerful and sustainable. This matrix is designed to enhance mental focus and mood while providing clean energy that works synergistically with the formula’s thermogenic compounds. By carefully balancing its stimulant profile, Pre Lean aims to deliver an energizing experience without the harsh crash that some pre-workouts can cause.

  • L-Tyrosine – 1500mg

    L-tyrosine is an amino acid that serves as a precursor to dopamine and norepinephrine – two crucial neurotransmitters that support focus, mood, and cognitive performance during intense exercise.[33]

    The 1500mg dose in Pre Lean is quite solid, falling right in line with research showing cognitive benefits in the 1000-2000mg range. While tyrosine is naturally present in protein-rich foods, supplemental tyrosine may be especially beneficial during demanding training sessions when these neurotransmitters can become depleted.[34]

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    What makes tyrosine interesting for a thermogenic pre-workout is its dual role in both cognitive and metabolic function. Not only does it help maintain focus and motivation during training, but tyrosine is also required for the production of thyroid hormones that regulate metabolism.[35]

    Research indicates tyrosine supplementation works best when you’re under stress or facing demanding cognitive tasks – like an intense training session. The compound helps prevent the decline in mental performance that often occurs during stressful situations, allowing you to maintain focus throughout your workout.[36]

    This makes tyrosine a smart addition to Pre Lean’s formula, supporting both the mental and physical demands of training while complementing its thermogenic properties.

  • Caffeine Complex (Caffeine Anhydrous, DiCaffeine Malate as infinergy) – 300mg

    Pre Lean delivers its 300mg caffeine through a dual-source blend of caffeine anhydrous and dicaffeine malate (as Infinergy). This strong and effective dose hits the sweet spot for most users, falling within the research-supported range of 3-6mg/kg body weight for performance enhancement,[37] but others may need to start with less than a full scoop.

    The combination of quick-releasing caffeine anhydrous with the time-released dicaffeine malate provides both immediate and sustained energy throughout your training session. This strategic blend helps avoid the rapid spike and crash that some users experience with single-source caffeine supplements.[38]

    Musclesport Collagen Peptides 2024 Fall Flavors

    Research shows that caffeine at this dosage can enhance several aspects of exercise performance, including increased power output, muscular endurance, and fat oxidation during training.[39] The thermogenic effects of caffeine work synergistically with Pre Lean’s other fat-metabolizing ingredients, as caffeine has been shown to increase metabolic rate and fat utilization during exercise.[40]

    For optimal results, new users should start with a half scoop to assess tolerance, especially if training later in the day, as caffeine’s effects can last 4-6 hours and potentially impact sleep quality when consumed too close to bedtime.[37]

  • CacaoRush Theobromine – 200mg

    Theobromine, a methylxanthine compound naturally found in cocoa beans, is included in Pre Lean’s energizing matrix at a research-supported 200mg dose. While often overshadowed by its cousin caffeine, theobromine provides unique benefits that complement Pre Lean’s thermogenic goals.

    Research shows that theobromine can enhance fat metabolism and modulate energy expenditure.[41] Its longer half-life compared to caffeine (approximately 7-12 hours vs 4-6 hours for caffeine) provides sustained effects throughout your training session.[42]

    Musclesport Pre Lean Ballistic Black Cherry

    Unlike caffeine’s intense stimulant effects, theobromine offers smoother energy without the jitters that some users experience from high-caffeine pre-workouts.[43] It also supports cardiovascular function by promoting vasodilation and healthy blood flow.[44]

    The combination of theobromine with caffeine in Pre Lean’s formula creates a sophisticated energy blend that provides both immediate and sustained effects, while supporting the supplement’s thermogenic and performance-enhancing goals.

Vitamins & Minerals

  • Niacin (Vitamin B3) – 25mg (156% DV)

    Niacin plays a crucial role in energy metabolism as a precursor to NAD+ and NADP+, two critical coenzymes involved in converting nutrients into cellular energy.[45] This makes it valuable during intense training sessions when energy demands are high.

    Research shows that niacin can enhance mitochondrial function and support metabolic flexibility – the body’s ability to switch between different fuel sources during exercise.[46] This complements Pre Lean’s thermogenic goals by helping optimize fat utilization during workouts.

    Additionally, niacin’s mild vasodilating properties can support the pump-enhancing effects of citrulline and other ingredients in the formula.[47] The moderate dose helps avoid the intense flushing sensation that higher amounts can cause while still providing meaningful metabolic support.

    MuscleSport Lean Way Plant'd Protella and Ice Cream Flavors

    At this dose, users get niacin’s metabolic benefits without the intense “flush” effect that higher doses can cause.[48] While smaller than the high doses used for cholesterol management, Pre Lean’s 25mg niacin inclusion provides meaningful benefits for a pre-workout formula. This may actually amplify the feelings from beta-alanine — a 25mg dose is generally the highest we’ll go with someone who doesn’t want a huge flush, however.

Flavors Available

Pre Lean launches in three flavors — below is a list of all that PricePlow has seen:

    Dosage and Instructions

    Take one scoop (15.5g) mixed with 8-12oz cold water approximately 20-30 minutes before training. Due to the potent thermogenic ingredients, start with ½ scoop to assess tolerance. Do not exceed one scoop per day.

    New users should assess tolerance with ½ scoop before moving to a full scoop.

    Stacking Options

    Pre Lean’s versatile formula works exceptionally well on its own, but strategic stacking with other Musclesport supplements can help you maximize your results based on your specific fitness goals.

    • Post-Workout Recovery

      Musclesport Pre Lean: A Thermogenic Pre-Workout Revolution

      The most obvious stack is pairing Pre Lean with Lean Whey post-workout. This combination creates a powerful fat-metabolizing system that works throughout your entire training session and recovery period. Since both products contain complementary fat-burning ingredients, they create a comprehensive approach to body composition goals.

      For those preferring natural ingredients or following a dairy-free lifestyle, Pre Lean also stacks perfectly with:

    • Enhanced Fat Metabolism

      For those specifically focused on maximizing fat loss, consider adding CarniShred + MitoBurn to your daily regimen. This strategic combination would bring your total daily L-carnitine intake to around 3g when combined with Pre Lean’s 1.5g carnitine complex – an optimal range for supporting fat oxidation without exceeding practical dosing requirements.

      The GBB in both products creates a synergistic effect, further enhancing carnitine utilization throughout the day, not just during your workout window.

    • Intra-Workout Support

      Musclesport Mass Revolution

      Muscle-building isn’t just about weightlifting—it’s about fueling your body with the right nutrients. Enter Mass Revolution, a gainer packed with protein, carbs, and added creatine to make bulking easy and tasty.

      For longer training sessions or fasted morning workouts, adding Amino + Hydration as an intra-workout supplement completes the perfect training trifecta:

      1. Pre Lean – Pre-workout thermogenic energy and performance
      2. Amino + Hydration – During-workout amino acid and electrolyte support
      3. Lean Whey – Post-workout recovery and continued fat metabolism

      This complete approach covers your entire training window with ingredients that support performance, hydration, recovery, and fat metabolism from start to finish.

      As with any supplement regimen, adjust based on your individual tolerance and goals. The half-scoop recommendation for Pre Lean is especially important when combining with other stimulant-containing products.

    Conclusion: The Evolution of Thermogenic Pre-Workouts

    Pre Lean represents the next logical evolution in both the pre-workout category and Musclesport’s expanding lineup of body composition focused supplements. By combining proven pre-workout staples with an innovative fat-metabolizing matrix, Musclesport has created a product that addresses two critical needs for physique-minded athletes: performance enhancement and metabolic support.

    What makes Pre Lean stand out in an increasingly crowded market is its thoughtful formulation approach. Rather than simply cramming trendy ingredients into the mix, each component serves a specific purpose within the formula’s overall strategy. The inclusion of clinical doses of research-backed ingredients like L-citrulline, beta-alanine, and tyrosine demonstrates Musclesport’s commitment to effectiveness, while innovative compounds like ProGBB and CapsiAtra show their dedication to staying at the cutting edge of sports nutrition.

    Musclesport Pre Lean Banner

    For athletes who’ve already experienced the benefits of Lean Whey’s fat-metabolizing system, Pre Lean offers a perfect complement that extends those benefits to the training window. The thermogenic properties can help maximize calorie burn during workouts, while the performance ingredients ensure you’re not sacrificing training intensity while pursuing body composition goals.

    As the supplement industry continues to mature, we expect to see more of these sophisticated, multi-functional formulas that address multiple aspects of performance and body composition simultaneously. Musclesport’s Pre Lean isn’t just riding this trend—it’s helping define it.

    Whether you’re looking to amplify your cutting phase, maximize training sessions during a calorie deficit, or simply want a pre-workout that delivers more than just stimulants, Pre Lean offers a compelling option worth considering. With its strategic launch at the 2025 Arnold Sports Festival, Pre Lean is positioned to make a significant impact in the thermogenic pre-workout category.

    Musclesport Pre Lean – Deals and Price Drop Alerts

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    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

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    About the Author: PricePlow Staff

    PricePlow Staff

    PricePlow is a team of supplement industry veterans that include medical students, competitive strength athletes, and scientific researchers who all became involved with dieting and supplements out of personal need.

    The team's collective experiences and research target athletic performance and body composition goals, relying on low-toxicity meat-based diets.

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