Stress comes in many forms, such as physical, biochemical, and emotional. Stress is also classified as acute or chronic. For example, running away from a bear is an acute stressor, whereas daily stressors at the workplace can develop into chronic stress. Whether you’re exposed to an acute or a chronic stressor, the body reacts by releasing the hormone cortisol. Cortisol regulates responses in several systems of the body, mainly cardiovascular, immune, central nervous, and digestive.
Once cortisol is released, several physiological processes begin, including:
- Blood sugar levels rise
- Bone formation reduces
- Muscle-protein breakdown increases
- Insulin secretion decreases
- Fatty-acid metabolism increases
- Immune system downregulates
- Heart rate increases
- Blood pressure increases
- Digestion reduces
Overall, cortisol is known as the body’s fight-or-flight hormone because it prepares your body for survival. Furthermore, it plays a key role in the sympathetic nervous system, which is activated under stressful situations. Typically, cortisol levels peak in the morning when you wake and decline throughout the day as you approach sleep. It’s important to note that stress and cortisol are a normal and necessary part of life, but being stressed over an extended period of time can lead to chronically elevated cortisol levels, which can take a toll on your health.
The Power of Adaptogens for Mitigating Stress
Regardless of who you are or what your goals are, keeping stress to a minimum is key to maximizing performance, health, and overall well-being. But that’s often easier said than done. Although there are several different ways that people cope with stress, one that’s often overlooked is supplementing with adaptogenic herbs.
For a plant to be classified as an adaptogen it must be shown in the literature to promote homeostasis through the regulation of physiological processes. In layman’s terms, an adaptogen helps the body adapt and overcome physical, biological, and chemical stress. Many adaptogens carry out their stress-reducing effects by lowering cortisol levels.
NNB RhodioPrime 6x: Standardized to Contain 6% Salidroside
One of the most researched and well-known adaptogenic herbs is Rhodiola. It also goes by the names arctic root and golden root. Rhodiola has been used for centuries to increase mood and energy levels. Today, there’s a robust amount of literature that supports these uses, among others.[1,2] Rhodiola can be found in a variety of sports nutrition supplements, but the strength, standardization, and species of the herb used in the product can have a huge impact on its effectiveness.
NNB Nutrition, a leader in branded-ingredient research and development, such as the patent-pending MitoBurn, CaloriBurn, and patented GlucoVantage, has just released a Rhodiola extract that could be the most powerful one yet. This new trademarked ingredient is known as RhodioPrime 6X because it’s standardized to contain at least 6% salidroside! There are over 140 bioactive compounds that have been isolated from Rhodiola, but according to the literature, the primary one attributed to its benefits is salidroside.
Keep reading to learn more about RhodioPrime 6X, salidroside, and the advantages of supplementing with Rhodiola! For more NNB Nutrition news, reviews, and interviews, just subscribe below!
Subscribe to PricePlow's Newsletter and Alerts on These Topics
An Overview on Rhodiola and Salidroside
Before making its way into the sports nutrition industry, Rhodiola was most notably used in traditional Chinese medicine and by Scandinavian Vikings. Rhodiola can be found growing in high altitude, low-temperature areas of Asia and Europe. Interestingly enough, there are nearly 20 species of Rhodiola. However, the majority of research has been performed on either Rhodiola rosea or Rhodiola crenulata.
Despite the similar names, there’s actually a distinct difference between the two species and it lies in their bioactive constituents. Rhodiola rosea contains high amounts of both rosavin and salidroside, whereas the salidroside content in Rhodiola crenulata is much higher.[1,3] Research shows that rosavin and salidroside compounds contribute to rhodiola’s benefits, but salidroside may contribute just a little more in certain areas.[4,5] Furthermore, rosavins are exclusively found in the Rhodiola rosea species.
Salidroside: Mechanisms of Action
Salidroside works through various mechanisms of action, such as:
- Increases long-term-potentiation of synaptic transmission in the hippocampus
- Corrects the mammalian of rapamycin (mTOR) pathway
- Regulates hypoxia-inducible factor -1 (HIF-1)
- Influences the release and uptake of five neurotransmitters (dopamine, norepinephrine, epinephrine, histamine, and serotonin)
- Inhibits monoamine oxidase (MOA)
- Increases neuropeptide Y activity
- Improves gut microbiota, combating obesity
It has also been shown to have hormetic effects with a large stimulatory zone.
Benefits of Rhodiola
Through these complex physiological mechanisms, Rhodiola may be able to:
- Improve memory, learning, and cognition
- Reduce stress and anxiety
- Enhance overall mood
- Decrease symptoms of depression
- Combat physical and mental fatigue[14,15]
- Improve athletic performance
- Regulate appetite
- Improve blood glucose levels
To get the majority of the benefits Rhodiola has to offer, it’s recommended to take anywhere from 200 milligrams to 600 milligrams per day.[1,19]. Research shows that supplementing with Rhodiola is extremely safe and there have been very few adverse effects reported.[1,19] Since many of Rhodiola’s benefits are attributed to its salidroside content, it’s important to find a high-quality extract that’s standardized to contain a certain amount of this bioactive compound. That’s where RhodioPrime comes into the picture!
If you want to dive deeper into the research behind Rhodiola, check out this in-depth article: Rhodiola: The Salidroside-Powered Adaptogen of the Vikings.
Rhodiola Explained (our long explainer video)
For more details atop our big article linked above, see our Rhodiola explanation:
The RhodioPrime Difference
Based on the literature, to get the most benefits from Rhodiola, you should try to find an extract with the highest salidroside content. So far, RhodioPrime 6X from NNB Nutrition is the only extract on the market that’s standardized to contain 6% salidroside, which is unheard of! Most Rhodiola extracts in sports nutrition contain 1% salidroside and 3% rosavin.
Part of the reason NNB Nutrition was able to accomplish this was because they used the Rhodiola crenulata species, as opposed to Rhodiola rosea. As we mentioned above, Rhodiola crenulata has a much higher salidroside content than any other form, so it lends itself well to creating a 6% salidroside extract.
When looking at Rhodiola-based supplements, remember – not all Rhodiola extracts are created equal.
Check out the RhodioPrime 6X Whitepaper
For more details atop our main rhodiola blog post, NNB Nutrition has also published an incredible whitepaper detailing the ingredient’s mechanisms and successful trials it has undergone.
RhodioPrime 6X in one minute:
Look for RhodioPrime 6X on the supplement facts panel!
Fortunately, you won’t have to worry about this issue with RhodioPrime 6X. NNB Nutrition puts their ingredients through rigorous testing to ensure that they contain exactly what they’re supposed to. RhodioPrime 6X is a lab-tested, unadulterated, high-quality form of Rhodiola crenulata. By standardizing RhodioPrime 6X to contain 6% of Rhodiola’s primary bioactive constituent, it’s designed to be more effective than the standard Rhodiola rosea extract.
Since RhodioPrime 6X only contains salidroside, it can even be combined with Rhodiola rosea to get the benefits of the higher rosavin content as well. RhodioPrime 6X could be also used to test the research-supported effects of salidroside on its own, or even amplify the salidroside content of a Rhodiola rosea extract. As of writing this article, no brands are using RhodioPrime 6X yet, but as soon as it’s available, we’ll let you know where you can find it! Just know that if you want to get the most out of Rhodiola, look for RhodioPrime 6X on the supplement facts panel.
NNB Nutrition is all about taking research-proven ingredients and making them even better through cutting edge scientific methods. Stay tuned for more news on RhodioPrime 6X and subscribe below so you don’t miss out on what’s to come from NNB Nutrition!
Subscribe to PricePlow's Newsletter and Alerts on These Topics
All PricePlow Articles Mentioning RhodioPrime
- HyperMax'D OUT: Performax Labs INSANITY Pre-Workout Now Available Posted on: November 17, 2023
- Glaxon Specimen Max: High-Stim Pre-Workout Made with PEZ Power Posted on: October 17, 2023
- Morphogen Nutrition COGNIGEN Nootropic: The Perfect Focus Add-On Posted on: September 18, 2023
- NNB RhodioPrime 6X: The Strongest Rhodiola Extract (6% Salidroside) Posted on: June 10, 2023
- New Rhodiola Salidroside Research: Neuroprotective Hormesis & Gut Health Posted on: June 2, 2023
- Morphogen Nutrition CALM: Stress + Anxiety Support Posted on: March 22, 2023
- Ekkovision DETHRONER: Consider Your Pre-Workout Dethroned Posted on: September 7, 2022
- Formulator's Corner #08: Mitochondria-Boosting Pre-Workout RTD Posted on: July 20, 2022
- GUMMIES Now Offered for Novel NNB Nutrition Ingredients Posted on: June 30, 2022
- Alpha Lion 2022 Update with Drew Peters | Episode #065 Posted on: April 14, 2022
- Formulator’s Corner #07: Armada Nutrition's Arnold Sports Festival Nootropic Posted on: April 4, 2022
- Beast Mode X Revealed by Beast Sports Nutrition Posted on: February 8, 2022
- Formulator's Corner #05: Mitochondria-Enhancing Pre-Workout Supplement Posted on: November 29, 2021
- Formulator's Corner #04: An Elite Women's Health Supplement in TWO Caps Posted on: September 8, 2021
- Unlock Your Fat Loss with UNBOUND's UNLOCK Posted on: July 22, 2021
- Formulator's Corner #03: A Health-Enhanced COFFEE Posted on: July 13, 2021
- Unbound UNLOAD Pre Workout: Prepare to Unload on the Weights Posted on: June 17, 2021
- Formulator's Corner #01: A Better Nootropic Coffee Creamer Posted on: March 23, 2021
Note: This article was originally published December 2, 2020 and updated in June 2023 with research on hormesis and gut health. Those topics are covered in depth in our article titled “New Rhodiola Salidroside Research: Neuroprotective Hormesis & Gut Health“.