NNB RhodioPrime 6X: The Strongest Rhodiola Extract (6% Salidroside)

Stress comes in many forms, such as physical, biochemical, and emotional. Stress is also classified as acute or chronic. For example, running away from a bear is an acute stressor, whereas daily stressors at the workplace can develop into chronic stress. Whether you’re exposed to an acute or a chronic stressor, the body reacts by releasing the hormone cortisol. Cortisol regulates responses in several systems of the body, mainly cardiovascular, immune, central nervous, and digestive.


Rhodiola: The Adaptogen Powered by Salidroside. In this article, we dive deep into RhodioPrime 6X, a different approach to the adaptogenic herb!

Once cortisol is released, several physiological processes begin, including:

  • Blood sugar levels rise
  • Bone formation reduces
  • Muscle-protein breakdown increases
  • Insulin secretion decreases
  • Fatty-acid metabolism increases
  • Immune system downregulates
  • Heart rate increases
  • Blood pressure increases
  • Digestion reduces

Overall, cortisol is known as the body’s fight-or-flight hormone because it prepares your body for survival. Furthermore, it plays a key role in the sympathetic nervous system, which is activated under stressful situations. Typically, cortisol levels peak in the morning when you wake and decline throughout the day as you approach sleep. It’s important to note that stress and cortisol are a normal and necessary part of life, but being stressed over an extended period of time can lead to chronically elevated cortisol levels, which can take a toll on your health.

The Power of Adaptogens for Mitigating Stress

Regardless of who you are or what your goals are, keeping stress to a minimum is key to maximizing performance, health, and overall well-being. But that’s often easier said than done. Although there are several different ways that people cope with stress, one that’s often overlooked is supplementing with adaptogenic herbs.

For a plant to be classified as an adaptogen it must be shown in the literature to promote homeostasis through the regulation of physiological processes. In layman’s terms, an adaptogen helps the body adapt and overcome physical, biological, and chemical stress. Many adaptogens carry out their stress-reducing effects by lowering cortisol levels.

NNB RhodioPrime 6x: Standardized to Contain 6% Salidroside


With a strong history of research, but weak extracts on the market, NNB Nutrition took it upon itself to solve the problem – with the salidroside-rich RhodioPrime 6X — 6% salidroside!

One of the most researched and well-known adaptogenic herbs is Rhodiola. It also goes by the names arctic root and golden root. Rhodiola has been used for centuries to increase mood and energy levels.[1] Today, there’s a robust amount of literature that supports these uses, among others.[1,2] Rhodiola can be found in a variety of sports nutrition supplements, but the strength, standardization, and species of the herb used in the product can have a huge impact on its effectiveness.

NNB Nutrition, a leader in branded-ingredient research and development, such as the patent-pending MitoBurn, CaloriBurn, and patented GlucoVantage, has just released a Rhodiola extract that could be the most powerful one yet. This new trademarked ingredient is known as RhodioPrime 6X because it’s standardized to contain at least 6% salidroside! There are over 140 bioactive compounds that have been isolated from Rhodiola, but according to the literature, the primary one attributed to its benefits is salidroside.[3]

Keep reading to learn more about RhodioPrime 6X, salidroside, and the advantages of supplementing with Rhodiola! For more NNB Nutrition news, reviews, and interviews, just subscribe below!

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An Overview on Rhodiola and Salidroside


Rhodiola: Our favorite feel-good herb with some additional workout boosting properties, thanks to the salidroside inside. Image courtesy Wikimedia

Before making its way into the sports nutrition industry, Rhodiola was most notably used in traditional Chinese medicine and by Scandinavian Vikings.[1] Rhodiola can be found growing in high altitude, low-temperature areas of Asia and Europe. Interestingly enough, there are nearly 20 species of Rhodiola. However, the majority of research has been performed on either Rhodiola rosea or Rhodiola crenulata.

Despite the similar names, there’s actually a distinct difference between the two species and it lies in their bioactive constituents. Rhodiola rosea contains high amounts of both rosavin and salidroside, whereas the salidroside content in Rhodiola crenulata is much higher.[1,3] Research shows that rosavin and salidroside compounds contribute to rhodiola’s benefits, but salidroside may contribute just a little more in certain areas.[4,5] Furthermore, rosavins are exclusively found in the Rhodiola rosea species.

Salidroside: Mechanisms of Action

Salidroside works through various mechanisms of action, such as:

  • Increases long-term-potentiation of synaptic transmission in the hippocampus[5]
  • Corrects the mammalian of rapamycin (mTOR) pathway[6]
  • Regulates hypoxia-inducible factor -1 (HIF-1)[7]
  • Influences the release and uptake of five neurotransmitters (dopamine, norepinephrine, epinephrine, histamine, and serotonin)[1]
  • Inhibits monoamine oxidase (MOA)[8]
  • Increases neuropeptide Y activity[9]
  • Improves gut microbiota, combating obesity[10]

It has also been shown to have hormetic effects with a large stimulatory zone.[11]

Benefits of Rhodiola

New research is showing that rhodiola extracts high in salidroside are the ones with the most potential… so why do so many supplements have such terrible standardizations? With RhodioPrime 6X, that all changes…

Through these complex physiological mechanisms, Rhodiola may be able to:

  • Improve memory, learning, and cognition[5]
  • Reduce stress and anxiety[12]
  • Enhance overall mood[12]
  • Decrease symptoms of depression[13]
  • Combat physical and mental fatigue[14,15]
  • Improve athletic performance[16]
  • Regulate appetite[17]
  • Improve blood glucose levels[18]

To get the majority of the benefits Rhodiola has to offer, it’s recommended to take anywhere from 200 milligrams to 600 milligrams per day.[1,19]. Research shows that supplementing with Rhodiola is extremely safe and there have been very few adverse effects reported.[1,19] Since many of Rhodiola’s benefits are attributed to its salidroside content, it’s important to find a high-quality extract that’s standardized to contain a certain amount of this bioactive compound. That’s where RhodioPrime comes into the picture!

If you want to dive deeper into the research behind Rhodiola, check out this in-depth article: Rhodiola: The Salidroside-Powered Adaptogen of the Vikings.

Rhodiola Explained (our long explainer video)

For more details atop our big article linked above, see our Rhodiola explanation:

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The RhodioPrime Difference

Based on the literature, to get the most benefits from Rhodiola, you should try to find an extract with the highest salidroside content. So far, RhodioPrime 6X from NNB Nutrition is the only extract on the market that’s standardized to contain 6% salidroside, which is unheard of! Most Rhodiola extracts in sports nutrition contain 1% salidroside and 3% rosavin.

Part of the reason NNB Nutrition was able to accomplish this was because they used the Rhodiola crenulata species, as opposed to Rhodiola rosea. As we mentioned above, Rhodiola crenulata has a much higher salidroside content than any other form, so it lends itself well to creating a 6% salidroside extract.

When looking at Rhodiola-based supplements, remember – not all Rhodiola extracts are created equal.

Check out the RhodioPrime 6X Whitepaper

For more details atop our main rhodiola blog post, NNB Nutrition has also published an incredible whitepaper detailing the ingredient’s mechanisms and successful trials it has undergone.[20]

RhodioPrime 6X in one minute:

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Look for RhodioPrime 6X on the supplement facts panel!

RhodioPrime NNB Nutrition

RhodioPrime 6X from NNB Nutrition is a trusted source! Image courtesy of Pixabay.

Fortunately, you won’t have to worry about this issue with RhodioPrime 6X. NNB Nutrition puts their ingredients through rigorous testing to ensure that they contain exactly what they’re supposed to. RhodioPrime 6X is a lab-tested, unadulterated, high-quality form of Rhodiola crenulata. By standardizing RhodioPrime 6X to contain 6% of Rhodiola’s primary bioactive constituent, it’s designed to be more effective than the standard Rhodiola rosea extract.

Since RhodioPrime 6X only contains salidroside, it can even be combined with Rhodiola rosea to get the benefits of the higher rosavin content as well. RhodioPrime 6X could be also used to test the research-supported effects of salidroside on its own, or even amplify the salidroside content of a Rhodiola rosea extract. As of writing this article, no brands are using RhodioPrime 6X yet, but as soon as it’s available, we’ll let you know where you can find it! Just know that if you want to get the most out of Rhodiola, look for RhodioPrime 6X on the supplement facts panel.

NNB Nutrition is all about taking research-proven ingredients and making them even better through cutting edge scientific methods. Stay tuned for more news on RhodioPrime 6X and subscribe below so you don’t miss out on what’s to come from NNB Nutrition!

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Note: This article was originally published December 2, 2020 and updated in June 2023 with research on hormesis and gut health. Those topics are covered in depth in our article titled “New Rhodiola Salidroside Research: Neuroprotective Hormesis & Gut Health.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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  1. Panossian, A. et al. June 2010. “Rosenroot (Rhodiola Rosea): Traditional Use, Chemical Composition, Pharmacology, and Clinical efficacy.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology vol. 17,7. 481-93. https://pubmed.ncbi.nlm.nih.gov/20378318/
  2. Jafari, M. et al. Dec. 2007. “Rhodiola: A Promising Anti-Aging Chinese Herb.” Rejuvenation Research vol. 10,4; 587-602. https://pubmed.ncbi.nlm.nih.gov/17990971/
  3. Grech-Baran, M. et al. June 2015. “Biotechnological Approaches to Enhance Salidroside, Rosin and Its Derivatives Production in Selected Rhodiola spp. in Vitro Cultures.” Phytochemistry Reviews: Proceedings of the Phytochemical Society of Europe vol. 14,4. 657-674. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513219/
  4. Li, Y. et al. Dec. 2017. “Rhodiola Rosea L.: An Herb with Anti-stress, Anti-aging, and Immunostimulating Properties for Cancer Chemoprevention.” Current Pharmacology Reports vol. 3,6; 384-395. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208354/
  5. Dimpfel, W. et al. May 2018. “Assessing the Quality and Potential Efficacy of Commercial Extracts of Rhodiola Rosea L. by Analyzing the Salidroside and Rosavin Content and the Electrophysiological Activity in Hippocampal Long-Term Potentiation, a Synaptic Model of Memory.” Frontiers in Pharmacology vol. 9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976749/
  6. Liu, Z. et al. Mar. 2012. “Rhodiola Rosea Extracts and Salidroside Decrease the Growth of Bladder Cancer Cell Lines via Inhibition of The mTOR Pathway and Induction of Autophagy.” Molecular Carcinogenesis vol. 51,3; 257-67. https://www.ncbi.nlm.nih.gov/pubmed/21520297/
  7. Zheng, K. et al. Mar. 2012/ “Salidroside Stimulates the Accumulation of HIF-1α Protein Resulted in the Induction of EPO Expression: A Signaling via Blocking the Degradation Pathway in Kidney and Liver Cells.” European Journal of Pharmacology vol. 679,1-3; 34-9. https://pubmed.ncbi.nlm.nih.gov/22309741/
  8. Van Diermen, D. et al. Mar. 2009. “Monoamine Oxidase Inhibition by Rhodiola Rosea L. Roots.” Journal of Ethnopharmacology vol. 122,2; 397-401. https://pubmed.ncbi.nlm.nih.gov/19168123/
  9. Panossian, A. et al. Fen. 2012. “Adaptogens Stimulate Neuropeptide Y and hsp72 Expression and Release in Neuroglia Cells.” Frontiers in Neuroscience vol. 6,6. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269752/
  10. Liu, Jiuxi et al. “Salidroside protects mice from high-fat diet-induced obesity by modulating the gut microbiota.” International immunopharmacology, vol. 120 110278. 14 May. 2023, doi:10.1016/j.intimp.2023.110278; https://www.sciencedirect.com/science/article/abs/pii/S1567576923006008
  11. Calabrese, Edward J et al. “Rhodiola rosea and salidroside commonly induce hormesis, with particular focus on longevity and neuroprotection.” Chemico-biological interactions, vol. 380 110540. 9 May. 2023, doi:10.1016/j.cbi.2023.110540; https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(23)00207-7
  12. Cropley, M. et al. Dec. 2015. “The Effects of Rhodiola Rosea L. Extract on Anxiety, Stress, Cognition and Other Mood Symptoms.” Phytotherapy Research: PTR vol. 29,12; 1934-9. https://pubmed.ncbi.nlm.nih.gov/26502953/
  13. Darbinyan, V. et al. 2007. “Clinical Trial of Rhodiola Rosea L. Extract SHR-5 in the Treatment of Mild to Moderate Depression.” Nordic Journal of Psychiatry vol. 61,5; 343-8. https://pubmed.ncbi.nlm.nih.gov/17990195/
  14. Spasov, A. et al. April 2007. “A Double-Blind, Placebo-Controlled Pilot Study of the Stimulating and Adaptogenic Effect of Rhodiola Rosea SHR-5 Extract on the Fatigue of Students Caused by Stress During an Examination Period with a Repeated Low-Dose Regimen.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology vol. 7,2; 85-9. https://pubmed.ncbi.nlm.nih.gov/10839209/
  15. Shevtsov, V. et al. Mar. 2003. “A Randomized Trial of Two Different Doses of a SHR-5 Rhodiola Rosea Extract Versus Placebo and Control of Capacity for Mental Work.” Phytomedicine: International Journal of Phytotherapy and Phytopharmacology vol. 10,2-3; 95-105. https://pubmed.ncbi.nlm.nih.gov/12725561/
  16. De Bock, K. et al. June 2004. “Acute Rhodiola Rosea Intake can Improve Endurance Exercise Performance.” International Journal of Sport Nutrition and Exercise Metabolism vol. 14,3; 298-307. https://pubmed.ncbi.nlm.nih.gov/15256690/
  17. Cifani, C. et al. Dec. 2010. “Effect of Salidroside, Active Principle of Rhodiola Rosea Extract, on Binge Eating.” Physiology & Behavior vol. 101,5; 555-62. https://pubmed.ncbi.nlm.nih.gov/20837037/
  18. Mao, G. et al. Apr. 2010. “Protective Role of Salidroside Against Aging in a Mouse Model Induced by D-galactose.” Biomedical and Environmental Sciences: BES vol. 23,2; 161-6. https://pubmed.ncbi.nlm.nih.gov/20514993/
  19. Khanum, F. et al. Nov. 2006. “Rhodiola Rosea: A Versatile Adaptogen.” Comprehensive Reviews in Food Science and Food Safety. https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1541-4337.2005.tb00073.x
  20. NNB Nutrition; “RhodioPrime 6X:Powered Adaptogen of the Vikings”; March 14, 2021; https://blog.priceplow.com/wp-content/uploads/rhodioprime-6x-whitepaper-20200314.pdf

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