Merica Labz SUPRIMOS: The Supreme Amino Supplement

What a couple of years it’s been for Merica Labz, who kicked off their “restoration” with the fantastic rebranding of their BOOM Energy Drink and epic upgrade of Red, White, & Boom pre-workout supplement. Followed by other great hits like a new and improved Patriot’s Whey, the new Super Sized mass gainer, and of course the Liberty Ballz natural testosterone booster, and you have a brand that’s firing on all cylinders.

Merica Labz Suprimos

The Supreme Aminos – Suprimos by ‘Merica Labz!

Merica Labz Suprimos are back and better than ever

But what about those aminos? In Merica Labz land, they’re known as Suprimos, and they’re next to get the new branding experience.

They also come in two incredible new flavors we’ve seen in other Merica Labz supplements, Daytona Beach and Patriot Punch.

Let’s dig into the mix that has 10 grams of EAAS (from 7 grams of BCAAs and 3 grams of other EAAs), which comes with a big dose of taurine and the largest Aquamin dose we’ve seen to date. But first, check prices and flavor availability with PricePlow:

Merica Labz Suprimos – Deals and Price Drop Alerts

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Ingredients

In a single 1-scoop serving of Suprimos from Merica Labz, you get the following:

  • Branched-Chain Amino Acid (BCAA) 2:1:1 Blend – 7,000 mg

    Merica Labz Suprimos Ingredients

    When describing the ratios of a branched-chain amino acid (BCAA) blend, the formula goes leucine:isoleucine:valine – these three amino acids are the BCAAs.

    So here, as usual, we have more leucine than anything else. And that’s a good thing. Why do we want a higher proportion of leucine? Put simply, it’s the most anabolic of the BCAAs. When you’re in an anabolic state, it means you’re in the process of building and maintaining muscle mass.

    Although all three BCAAs exert anti-catabolic effects[1-3] and increase athletic endurance,[4-6] leucine is the most effective for stimulating new muscle synthesis.[7-9] As we age, it’s normal to need more and more leucine to achieve the same end result.[10]

    Leucine initiates muscle protein synthesis by activating mTOR, the mammalian target of rapamycin,[11-13] which is basically the “master switch” for our body’s anabolic response to exercise.

  • Essential Amino Acid Blend – 3,000 mg

    One of the reasons people take BCAA supplements is that they’re “essential”, which means that our bodies cannot synthesize them endogenously (on their own). Instead, we must obtain these aminos from an external source like food or supplements.

    Although the three BCAAs are all essential amino acids, they’re not the only essential amino acids. As it turns out, there are six others.

    Essential Amino Acids

    Amongst these primary amino acids, the essential amino acids are in red. Leucine, Valine, and Isoleucine are the three Branched-Chain Amino Acids.

    All nine essential amino acids are important for optimal muscle synthesis,[14] and beyond that, each has its own unique properties.

    • L-Lysine – 1525 mg

      Lysine is an important precursor to carnitine,[15] a quaternary ammonium compound that comes with a multitude of benefits for human health. Like most of the other essential amino acids, lysine helps with performance and recovery.[16,17]

      Lysine is also centrally involved in calcium metabolism, where it both helps the body absorb calcium[18] and also regulate where the mineral is deposited. For example, itt keeps calcium out of your veins and arteries and shuttles it to your bones, where it’s supposed to be.[18]

      Because lysine also plays a role in the production of collagen,[19] it’s argued that lysine is needed for the structural support of your entire body because muscles basically hang on a scaffolding of bones and collagenous tendons!

      Both bones and tendons are strained by intense exercise, whether it’s high-impact cardio or weightlifting. So giving your body some extra lysine is a good way to help prevent the kind of catastrophic injury that can follow improper recovery.

    • L-Threonine – 1000 mg

      Merica Labz Suprimos

      Glycine and serine are two highly beneficial amino acids that are crucial for the proper functioning of the central nervous system. Without threonine, your body can’t make either one of them.[20]

      You also need threonine for maximum muscle protein synthesis,[21] so supplementing with it can help you avoid anabolic bottlenecks.

    • L-Phenylalanine – 200 mg

      Since phenylalanine is tyrosine precursor,[22] and tyrosine helps increase levels of dopamine, epinephrine, and norepinephrine,[23] increasing your phenylalanine intake is a good strategy for getting more of these key neurotransmitters. Even if you’re using your BCAA for post-workout recovery, it can still potentially help your next workout by keeping your phenylalanine stores full.

    • L-Histidine – 100 mg

      Histidine is an important precursor for carnosine, a protein building block that can increase athletic endurance and speed recovery by “buffering” lactic acid in muscle tissue.[24] Animal studies have demonstrated that histidine deficiencies can impair muscle protein synthesis, and furthermore, elevated histidine levels can accelerate muscle protein synthesis, making it faster than baseline.[25] So histidine is another amino acid that can be useful as a supplement, even when you’re not deficient.

    • L-Tryptophan – 100 mg

      Merica Labz Suprimos

      You thought Alpine Pew Pew Merica Energy was the original of this flavor? Not so fast! It’s been out with Suprimos for far longer!

      Old wives’ tales notwithstanding, tryptophan doesn’t actually make you sleepy after eating certain foods, but it does increase pain tolerance[26] and can improve mood by upping serotonin production in the brain.[27]

    • L-Methionine – 75 mg

      The amino acid methionine is an antioxidant, helping protect your body from the oxidative stress associated with exercise.[28] Methionine is eventually used by your body to produce taurine and cysteine, two amino acids that are important for optimal performance and recovery.

      Methionine is also a precursor for carnitine,[29] an important substance that helps your metabolism by transporting fatty acids. We discussed the amino acid above. Methionine intake and carnitine blood levels are tightly correlated.[29]

  • Taurine – 2500 mg

    Nutritional superstar, taurine, is not included in the “essential amino acid” blend because it’s conditionally essential,[30] meaning that although your body can create some taurine on its own, it can’t produce enough of it. To achieve optimal taurine status, you need a little extra from food or supplements. Experts agree that for our purposes, more taurine is usually better.

    Taurine Endurance

    Taurine’s effect on endurance, with success in doses anywhere from 1 gram to 6 grams.[31]

    The first thing you should know about taurine is that it’s awesome for mitochondrial health.[32] This is a really big deal since the ability of your mitochondria to produce cellular energy affects every single process in your body, which is basically a machine designed to fight entropy. In order to do that, the body needs as much energy as possible. Over many years, energy insufficiency at the cellular will cause the decline in whole-body function that’s associated with aging.

    Taurine is also an osmolyte, meaning that it maintains the proper amount of water in your cells.[33] An osmolyte is basically the opposite of a diuretic.

    Obviously, cellular hydration goes a long way toward optimizing athletic performance and recovery. So partly because of its status as an osmolyte, and partly because of its pro-mitochondrial effects, taurine can significantly increase physical endurance.[31]

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    Taurine is distributed to pretty much all tissues in your body. Some of its other roles include helping protect cells and their membranes against oxidative damage and promoting calcium signaling between cells to facilitate muscle contraction.[31,33-36]

    Antioxidant activity of taurine is part of the reason it’s able to protect the brain against inflammation and stress, thereby increasing focus. It also upregulates the brain’s GABA receptors and makes neuronal synapses more active.[34]

    The upshot of all these effects on the brain is that taurine helps new neurons grow, even the presence of neurotoxins. Also, it has been identified as a crucial factor in optimal brain development.[37]

    Lastly, taurine upregulates nitric oxide,[35] which any gym rat knows is crucial for a great pump and faster recovery.

  • Aquamin Sea Minerals – 1000 mg

    The Aquamin sea mineral complex is sourced from seaweed and contains mostly calcium and magnesium, with trace amounts of boron and manganese.[38] Studies on Aquamin supplementation — including these four minerals — have shown that it’s capable of significantly improving bone and joint health.[38-40]

    Merica Labz Stars 'N Pipes

    Presenting the updated Stars ‘N Pipes formula from Merica Labz – now with HydroPrime glycerol and Nitrosigine for incredible pumps from multiple angles!

    Based on the theory that boron interferes with the binding of testosterone to sex-hormone binding globulin,[41] men usually take it in order to raise free testosterone levels in the blood.[42] The limited research that’s been done on this subject indicates that boron might actually be capable of raising free T, but we need to see a lot more research before endorsing such a declaration.

    Exercise can deplete your body of all these minerals and more,[42,43] especially if you’re doing intense cardio, so it’s a great idea to pack these minerals in with BCAAs.[44]

    According to the label, you are getting:

    • 100 milligrams of potassium (2% DV)
    • 100 milligrams of sodium (4% DV)
    • 170 milligrams of calcium (17% DV)

    from Aquamin.

    But don’t miss the magnesium that comes next:

  • Magnesium (from Magnesium Glycinate) – 160mg (40% DV)

    The label sneaks in a quite large amount of magnesium coming from magnesium glycinate, our preferred form of magnesium. Each scoop gets you 160 milligrams of elemental magnesium, which is 40% of the US RDA – quite an excellent addition to your diet.

    With magnesium glycinate, we get the benefits of both the mineral and the amino acid it’s bound to – glycine! Studies show that it has far superior absorption compared to cheaper magnesium oxide.[45]

    Let’s break it in half to look at the benefits of both parts inside:

    • The magnesium side

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      Magnesium leads to numerous metabolic benefits, including reduced blood sugar, lower blood sugar and insulin levels, and overall increased insulin sensitivity.[46-52] In terms athletic effects, there are also benefits like improved lactate clearance[53] and increased muscle mass and power.[54]

      Too many Americans are magnesium-deficient, which can lead to added anxiety, stress, and overall fatigue.[55-57] Normally, you wouldn’t expect your intra workout supplement to assist with this, but 40% of the daily recommended value can certainly put a huge dent on deficiency.

    • The glycine side

      The other half of the magnesium glycinate molecule is glycine, a conditionally essential amino acid that has similar stress-reducing, metabolic-supporting effects when taken. It’s conditionally essential because the body can produce it from other aminos, but we almost always do better with more – especially since we don’t eat as many glycine-rich food sources as we should.

      Magnesium Glycinate vs. Magnesium Oxide

      Magnesium glycinate (black) greatly outperforms magnesium oxide (white).[45]

      Glycine assists with protein synthesis, especially for collagen, elastin, and other connective tissue.[58] It makes sense to have a source inside of a supplement like Suprimos.

      Much of glycine’s research is centered around improved sleep.[59-70] However, the clinical dose is generally 3 grams per day taken before bed, which is more than we’ll have here, but we’ll take any improvements we can.

      Users may also see cognitive improvements when using glycine,[71] but again that was with 3 grams of glycine per day.

    Overall, this is an incredible form of magnesium that not only provides better bioavailability and absorption, but its “carrier” amino acid also has incredible benefits itself! We have much more on this ingredient, which is in our guide titled Magnesium Glycinate: A Master Class in Magnesium & Glycine.

Flavors available

Merica Labz Suprimos Aminos

    Suprimos: The Supreme Aminos

    Suprimos is a solid EAA formula that hits added hydration without costing an arm and a leg. This is the more “simple” EAA formula, as opposed to something more complex like Core INTRA.

    Oftentimes, you just want to keep the amino acids flowing and hydration on point. This does that quite well, given the largest-ever dose of AquaMin we’ve covered yet. But what most users may miss is the incredible magnesium glycinate inside, which we’ll never say no to.

    So if you’re ready for some supreme aminos that keep it smart and simple, take a look at the refreshed Merica Labz Suprimos.

    Merica Labz Suprimos – Deals and Price Drop Alerts

    Get Price Alerts

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    Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

    Posts are sponsored in part by the retailers and/or brands listed on this page.

    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public. Mike is currently experimenting with a low Vitamin A diet.

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    References

    1. Freund, H et al. “Infusion of the branched chain amino acids in postoperative patients. Anticatabolic properties.” Annals of surgery vol. 190,1 (1979): 18-23. doi:10.1097/00000658-197907000-00004; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1344449/
    2. Wolfe, RR; “Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?”; J Int Soc Sports Nutr; 14(1):30; 2017; https://jissn.biomedcentral.com/articles/10.1186/s12970-017-0184-9
    3. Kobayashi H, Kato H, Hirabayashi Y, Murakami H, Suzuki H; “Modulations of muscle protein metabolism by branched-chain amino acids in normal and muscle-atrophying rats”; J Nutr. 2006;136; https://pubmed.ncbi.nlm.nih.gov/16365089
    4. Ea, Newsholme, and Blomstrand E. “Branched-Chain Amino Acids and Central Fatigue.” The Journal of Nutrition, 1 Jan. 2006; https://pubmed.ncbi.nlm.nih.gov/16365097/
    5. E, Blomstrand, et al. “Administration of Branched-Chain Amino Acids during Sustained Exercise–Effects on Performance and on Plasma Concentration of Some Amino Acids.” European Journal of Applied Physiology and Occupational Physiology, 1991; https://pubmed.ncbi.nlm.nih.gov/1748109/
    6. Ab, Gualano, et al. “Branched-Chain Amino Acids Supplementation Enhances Exercise Capacity and Lipid Oxidation during Endurance Exercise after Muscle Glycogen Depletion.” The Journal of Sports Medicine and Physical Fitness, 1 Mar. 2011; https://pubmed.ncbi.nlm.nih.gov/21297567/
    7. Anthony JC, Anthony TG, Kimball SR, Jefferson LS. Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine. J Nutr. 2001 Mar;131(3):856S-860S. doi: 10.1093/jn/131.3.856S. PMID: 11238774. https://pubmed.ncbi.nlm.nih.gov/11238774/
    8. Ham DJ, Caldow MK, Lynch GS, Koopman R. Leucine as a treatment for muscle wasting: a critical review. Clin Nutr. 2014 Dec;33(6):937-45. doi: 10.1016/j.clnu.2014.09.016. PMID: 25444557. https://pubmed.ncbi.nlm.nih.gov/25444557/
    9. Mero A. Leucine supplementation and intensive training. Sports Med. 1999 Jun;27(6):347-58. doi: 10.2165/00007256-199927060-00001. PMID: 10418071. https://pubmed.ncbi.nlm.nih.gov/10418071/
    10. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E381-7. doi: 10.1152/ajpendo.00488.2005. Epub 2006 Feb 28. PMID: 16507602. https://pubmed.ncbi.nlm.nih.gov/16507602/
    11. Lynch, Christopher J., et al. “Leucine Is a Direct-Acting Nutrient Signal That Regulates Protein Synthesis in Adipose Tissue.” American Journal of Physiology-Endocrinology and Metabolism, vol. 283, no. 3, Sept. 2002, pp. E503–E513, 10.1152/ajpendo.00084.2002; https://journals.physiology.org/doi/full/10.1152/ajpendo.00084.2002
    12. Lynch, Christopher J., et al. “Tissue-Specific Effects of Chronic Dietary Leucine and Norleucine Supplementation on Protein Synthesis in Rats.” American Journal of Physiology-Endocrinology and Metabolism, vol. 283, no. 4, 1 Oct. 2002, pp. E824–E835, 10.1152/ajpendo.00085.2002; https://journals.physiology.org/doi/full/10.1152/ajpendo.00085.2002
    13. Lynch, C. J., et al. “Regulation of Amino Acid-Sensitive TOR Signaling by Leucine Analogues in Adipocytes.” Journal of Cellular Biochemistry, vol. 77, no. 2, 1 Mar. 2000, pp. 234–251; https://pubmed.ncbi.nlm.nih.gov/10723090/
    14. Church DD, Hirsch KR, Park S, Kim IY, Gwin JA, Pasiakos SM, Wolfe RR, Ferrando AA. Essential Amino Acids and Protein Synthesis: Insights into Maximizing the Muscle and Whole-Body Response to Feeding. Nutrients. 2020 Dec 2;12(12):3717. doi: 10.3390/nu12123717. PMID: 33276485; PMCID: PMC7760188. https://pubmed.ncbi.nlm.nih.gov/33276485/
    15. Lara, B., Gallo-Salazar, C., Puente, C., Areces, F., Salinero, J. J., & Del Coso, J. (2016). “Interindividual variability in sweat electrolyte concentration in marathoners”; Journal of the International Society of Sports Nutrition, 13, 31; http://doi.org/10.1186/s12970-016-0141-zhttps://umm.edu/health/medical/altmed/supplement/lysine;
    16. Dort, J., Leblanc, N., Maltais-Giguère, J., Liaset, B., Côté, C. H., & Jacques, H. (2013). Beneficial Effects of Cod Protein on Inflammatory Cell Accumulation in Rat Skeletal Muscle after Injury Are Driven by Its High Levels of Arginine, Glycine, Taurine and Lysine. PLoS ONE, 8(10). doi:10.1371/journal.pone.0077274; https://www.ncbi.nlm.nih.gov/pubmed/24124612
    17. Cai WC, Liu WB, Jiang GZ, Wang KZ, Sun CX, Li XF. Lysine supplement benefits the growth performance, protein synthesis, and muscle development of Megalobrama amblycephala fed diets with fish meal replaced by rice protein concentrate. Fish Physiol Biochem. 2018 Aug;44(4):1159-1174. doi: 10.1007/s10695-018-0503-3. Epub 2018 May 5. PMID: 29730709. https://pubmed.ncbi.nlm.nih.gov/29730709/
    18. Yamauchi, Mitsuo, and Marnisa Sricholpech. “Lysine post-translational modifications of collagen.” Essays in biochemistry vol. 52 (2012): 113-33. doi:10.1042/bse0520113 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499978/
    19. Pekala J, Patkowska-Sokoła B, Bodkowski R, Jamroz D, Nowakowski P, Lochyński S, Librowski T. L-carnitine–metabolic functions and meaning in humans life. Curr Drug Metab. 2011 Sep;12(7):667-78. doi: 10.2174/138920011796504536. PMID: 21561431. https://pubmed.ncbi.nlm.nih.gov/21561431/
    20. “Threonine – an Overview | ScienceDirect Topics.” Www.sciencedirect.com, www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/threonine.
    21. Feng L, Peng Y, Wu P, Hu K, Jiang W-D, Liu Y, et al. (2013) Threonine Affects Intestinal Function, Protein Synthesis and Gene Expression of TOR in Jian Carp (Cyprinus carpio var. Jian). PLoS ONE 8(7): e69974. https://doi.org/10.1371/journal.pone.0069974. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069974
    22. Shimomura, Akihiro et al. “Dietary L-lysine prevents arterial calcification in adenine-induced uremic rats.” Journal of the American Society of Nephrology : JASN vol. 25,9 (2014): 1954-65. doi:10.1681/ASN.2013090967 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147981/
    23. National Center for Biotechnology Information. “PubChem Compound Summary for CID 6140, Phenylalanine” PubChem, https://pubchem.ncbi.nlm.nih.gov/compound/Phenylalanine. Accessed 30 November, 2021.
    24. Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
    25. Salah, E, Garbilla, Alan j. Sinclair, Carnosine: physiological properties and therapeutic potential. Age and Ageing; 2000; 29: 207-210 http://www.ncbi.nlm.nih.gov/pubmed/10855900
    26. Seltzer S, Dewart D, Pollack RL, Jackson E. The effects of dietary tryptophan on chronic maxillofacial pain and experimental pain tolerance. J Psychiatr Res. 1982-1983;17(2):181-6. doi: 10.1016/0022-3956(82)90020-6. PMID: 6764935. https://pubmed.ncbi.nlm.nih.gov/6764935/
    27. Bravo R, Matito S, Cubero J, Paredes SD, Franco L, Rivero M, Rodríguez AB, Barriga C. Tryptophan-enriched cereal intake improves nocturnal sleep, melatonin, serotonin, and total antioxidant capacity levels and mood in elderly humans. Age (Dordr). 2013 Aug;35(4):1277-85. doi: 10.1007/s11357-012-9419-5. Epub 2012 May 24. PMID: 22622709; PMCID: PMC3705114. https://pubmed.ncbi.nlm.nih.gov/26560523/
    28. Luo, Shen, and Rodney L Levine. “Methionine in proteins defends against oxidative stress.” FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 23,2 (2009): 464-72. doi:10.1096/fj.08-118414 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2630790/
    29. Krajcovicová-Kudlácková M, Simoncic R, Béderová A, Babinská K, Béder I. Correlation of carnitine levels to methionine and lysine intake. Physiol Res. 2000;49(3):399-402. PMID: 11043928. https://pubmed.ncbi.nlm.nih.gov/11043928/
    30. Lourenço, R., and M. E. Camilo. “Taurine: A Conditionally Essential Amino Acid in Humans? An Overview in Health and Disease.” Nutricion Hospitalaria, vol. 17, no. 6, 1 Nov. 2002, pp. 262–270; https://pubmed.ncbi.nlm.nih.gov/12514918/
    31. Waldron, M., et al. May 2018. “The Effects of an Oral Taurine Dose and Supplementation Period on Endurance Exercise Performance in Humans: A Meta-Analysis.” Sports Medicine vol. 48,5; 1247-53. https://pubmed.ncbi.nlm.nih.gov/29546641
    32. Jong, Chian Ju, et al. “The Role of Taurine in Mitochondria Health: More than Just an Antioxidant.” Molecules, vol. 26, no. 16, 13 Aug. 2021, p. 4913, 10.3390/molecules26164913; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400259/
    33. Ripps, H. et al. Nov. 2012. “Review: Taurine: A “Very Essential Amino Acid.” Molecular Vision vol. 18. 2673-86. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501277/
    34. Chen, C. et al. Aug. 2019. “Roles of Taurine in Cognitive Function of Physiology, Pathologies, and Toxication.” Life Sciences vol. 15, 231; https://pubmed.ncbi.nlm.nih.gov/31220527/
    35. Guizoni, D. et al. Jan. 2020. “Modulation of Endothelium-Derived Nitric Oxide Production and Activity by Taurine and Taurine-Conjugated Bile Acids.” Nitric Oxide vol. 94,1; 48-53; https://www.sciencedirect.com/science/article/abs/pii/S1089860319302113
    36. Murakami, Shigeru. “Role of Taurine in the Pathogenesis of Obesity.” Molecular Nutrition & Food Research, vol. 59, no. 7, 28 Apr. 2015, pp. 1353–1363, 10.1002/mnfr.201500067; https://pubmed.ncbi.nlm.nih.gov/25787113/
    37. Pasantes-Morales, Herminia, and Reyna Hernández-Benítez. “Taurine and Brain Development: Trophic or Cytoprotective Actions?” Neurochemical Research, vol. 35, no. 12, 1 Dec. 2010, pp. 1939–1943, 10.1007/s11064-010-0262-8; https://pubmed.ncbi.nlm.nih.gov/20842422/
    38. Frestedt JL, Kuskowski MA, Zenk JL; “A natural seaweed derived mineral supplement (Aquamin F) for knee osteoarthritis: a randomised, placebo controlled pilot study”; Nutr J. 2009; 8:7; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642861/
    39. Brennan O. et al; “Incorporation of the natural marine multi-mineral dietary supplement Aquamin enhances osteogenesis and improves the mechanical properties of a collagen-based bone graft substitute”; J Mech Behav Biomed Mater. 2015 Jul; 47:114-123; https://www.ncbi.nlm.nih.gov/pubmed/25884141
    40. Gaby, A. R. “Natural Treatments for Osteoarthritis.” Alternative Medicine Review: A Journal of Clinical Therapeutic, vol. 4, no. 5, 1 Oct. 1999, pp. 330–341; https://pubmed.ncbi.nlm.nih.gov/10559548/
    41. Bello M, Guadarrama-García C, Velasco-Silveyra LM, Farfán-García ED, Soriano-Ursúa MA. Several effects of boron are induced by uncoupling steroid hormones from their transporters in blood. Med Hypotheses. 2018 Sep;118:78-83. doi: 10.1016/j.mehy.2018.06.024. Epub 2018 Jun 20. PMID: 30037620. https://pubmed.ncbi.nlm.nih.gov/30037620/
    42. Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS. Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. J Trace Elem Med Biol. 2011 Jan;25(1):54-8. doi: 10.1016/j.jtemb.2010.10.001. Epub 2010 Dec 3. PMID: 21129941. https://pubmed.ncbi.nlm.nih.gov/21129941/
    43. Heffernan, Shane Michael et al. “The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review.” Nutrients vol. 11,3 696. 24 Mar. 2019, doi:10.3390/nu11030696 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471179/
    44. Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Nutritional Needs in Hot Environments: Applications for Military Personnel in Field Operations. Washington (DC): National Academies Press (US); 1993. 7, The Effect of Exercise and Heat on Mineral Metabolism and Requirements. Available from: https://www.ncbi.nlm.nih.gov/books/NBK236242/
    45. Schuette, S A, et al. “Bioavailability of Magnesium Diglycinate vs Magnesium Oxide in Patients with Ileal Resection.” JPEN. Journal of Parenteral and Enteral Nutrition, vol. 18, no. 5, 1994, pp. 430–5, 10.1177/0148607194018005430; https://pubmed.ncbi.nlm.nih.gov/7815675/
    46. Guerrero-Romero, Fernando, and Martha Rodríguez-Morán. “Magnesium Improves the Beta-Cell Function to Compensate Variation of Insulin Sensitivity: Double-Blind, Randomized Clinical Trial.” European Journal of Clinical Investigation, vol. 41, no. 4, 17 Jan. 2011, pp. 405–410, 10.1111/j.1365-2362.2010.02422.x; https://pubmed.ncbi.nlm.nih.gov/21241290/
    47. Hatzistavri, L. S., et al. “Oral Magnesium Supplementation Reduces Ambulatory Blood Pressure in Patients with Mild Hypertension.” American Journal of Hypertension, vol. 22, no. 10, 1 Oct. 2009, pp. 1070–1075, 10.1038/ajh.2009.126; https://pubmed.ncbi.nlm.nih.gov/19617879/
    48. Kawano, Yuhei, et al. “Effects of Magnesium Supplementation in Hypertensive Patients.” Hypertension, vol. 32, no. 2, Aug. 1998, pp. 260–265, 10.1161/01.hyp.32.2.260; https://pubmed.ncbi.nlm.nih.gov/9719052/
    49. Guerrero-Romero, F, and M Rodríguez-Morán. “The Effect of Lowering Blood Pressure by Magnesium Supplementation in Diabetic Hypertensive Adults with Low Serum Magnesium Levels: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.” Journal of Human Hypertension, vol. 23, no. 4, 20 Nov. 2008, pp. 245–251, 10.1038/jhh.2008.129; https://pubmed.ncbi.nlm.nih.gov/19020533/
    50. Rodriguez-Moran, M., and F. Guerrero-Romero. “Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic Control in Type 2 Diabetic Subjects: A Randomized Double-Blind Controlled Trial.” Diabetes Care, vol. 26, no. 4, 1 Apr. 2003, pp. 1147–1152, 10.2337/diacare.26.4.1147; https://pubmed.ncbi.nlm.nih.gov/12663588/
    51. Mooren, F. C., et al. “Oral Magnesium Supplementation Reduces Insulin Resistance in Non-Diabetic Subjects – a Double-Blind, Placebo-Controlled, Randomized Trial.” Diabetes, Obesity and Metabolism, vol. 13, no. 3, 24 Jan. 2011, pp. 281–284, 10.1111/j.1463-1326.2010.01332.x; https://pubmed.ncbi.nlm.nih.gov/21205110/
    52. Golf, S.W., et al. Cardiovascular Drugs and Therapy, vol. 12, no. 2suppl, 1998, pp. 197–202, 10.1023/a:1007708918683; https://pubmed.ncbi.nlm.nih.gov/9794094/
    53. Cinar, V., et al. “The Effect of Magnesium Supplementation on Lactate Levels of Sportsmen and Sedanter.” Acta Physiologica Hungarica, vol. 93, no. 2-3, 1 June 2006, pp. 137–144, 10.1556/aphysiol.93.2006.2-3.4; https://pubmed.ncbi.nlm.nih.gov/17063625/
    54. Welch AA, Kelaiditi E, Jennings A, Steves CJ, Spector TD, MacGregor A. Dietary Magnesium Is Positively Associated With Skeletal Muscle Power and Indices of Muscle Mass and May Attenuate the Association Between Circulating C-Reactive Protein and Muscle Mass in Women. J Bone Miner Res. 2016 Feb;31(2):317-25. doi: 10.1002/jbmr.2692; https://pubmed.ncbi.nlm.nih.gov/26288012/
    55. Cuciureanu MD, Vink R; “Magnesium and stress”; Magnesium in the Central Nervous System; https://www.ncbi.nlm.nih.gov/books/NBK507250/
    56. Ebrahimi, Elham, et al. “Effects of Magnesium and Vitamin B6 on the Severity of Premenstrual Syndrome Symptoms.” Journal of Caring Sciences, vol. 2012, no. 4, pp. 183–189, 10.5681/jcs.2012.026; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161081/
    57. L, Barragán-Rodríguez, et al. “Efficacy and Safety of Oral Magnesium Supplementation in the Treatment of Depression in the Elderly with Type 2 Diabetes: A Randomized, Equivalent Trial.” Magnesium Research, 1 Dec. 2008; https://pubmed.ncbi.nlm.nih.gov/19271419/
    58. Razak, Meerza Abdul, et al. “Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review.” Oxidative Medicine and Cellular Longevity, vol. 2017, 2017, pp. 1–8, 10.1155/2017/1716701. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350494/
    59. Inagawa, K; Subjective effects of glycine ingestion before bedtime on sleep quality; Sleep and Biological Rhythms, 4: 75–77; 2006; https://onlinelibrary.wiley.com/doi/10.1111/j.1479-8425.2006.00193.x/abstract
    60. Yamadera, Wataru, et al. “Glycine Ingestion Improves Subjective Sleep Quality in Human Volunteers, Correlating with Polysomnographic Changes.” Sleep and Biological Rhythms, vol. 5, no. 2, 27 Mar. 2007, pp. 126–131, 10.1111/j.1479-8425.2007.00262.x. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1479-8425.2007.00262.x
    61. Bannai, Makoto, et al. “The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers.” Frontiers in Neurology, vol. 3, 2012, 10.3389/fneur.2012.00061; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328957/
    62. Berger, Albert J. “What Causes Muscle Atonia in REM?” Sleep, vol. 31, no. 11, 2008, pp. 1477–8; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579974/
    63. Chase, MH, et al. “Evidence That Glycine Mediates the Postsynaptic Potentials That Inhibit Lumbar Motoneurons during the Atonia of Active Sleep.” The Journal of Neuroscience, vol. 9, no. 3, 1 Mar. 1989, pp. 743–751, 10.1523/JNEUROSCI.09-03-00743.1989; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6569981/
    64. Brooks, Patricia L., and John H. Peever. “Unraveling the Mechanisms of REM Sleep Atonia.” Sleep, vol. 31, no. 11, 1 Nov. 2008, pp. 1492–1497; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579970/
    65. Brooks, P. L., and J. H. Peever. “Identification of the Transmitter and Receptor Mechanisms Responsible for REM Sleep Paralysis.” Journal of Neuroscience, vol. 32, no. 29, 18 July 2012, pp. 9785–9795, 10.1523/jneurosci.0482-12.2012; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6621291/
    66. Cummings, Kirstie A., and Gabriela K. Popescu. “Glycine-Dependent Activation of NMDA Receptors.” The Journal of General Physiology, vol. 145, no. 6, 11 May 2015, pp. 513–527, 10.1085/jgp.201411302. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442789/
    67. Kawai, Nobuhiro, et al. “The Sleep-Promoting and Hypothermic Effects of Glycine Are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus.” Neuropsychopharmacology, vol. 40, no. 6, 1 May 2015, pp. 1405–1416, 10.1038/npp.2014.326; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397399/
    68. Inagawa, K; Subjective effects of glycine ingestion before bedtime on sleep quality; Sleep and Biological Rhythms, 4: 75–77; 2006; https://onlinelibrary.wiley.com/doi/10.1111/j.1479-8425.2006.00193.x/abstract
    69. Yamadera, Wataru, et al. “Glycine Ingestion Improves Subjective Sleep Quality in Human Volunteers, Correlating with Polysomnographic Changes.” Sleep and Biological Rhythms, vol. 5, no. 2, 27 Mar. 2007, pp. 126–131, 10.1111/j.1479-8425.2007.00262.x. https://onlinelibrary.wiley.com/doi/full/10.1111/j.1479-8425.2007.00262.x
    70. Bannai, Makoto, et al. “The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers.” Frontiers in Neurology, vol. 3, 2012, 10.3389/fneur.2012.00061. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328957/
    71. Bannai, Makoto, et al. “The Effects of Glycine on Subjective Daytime Performance in Partially Sleep-Restricted Healthy Volunteers.” Frontiers in Neurology, vol. 3, 2012, 10.3389/fneur.2012.00061. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328957/

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