MitoGreens: Ergothioneine-Amplified Antioxidant Blend by NNB Nutrition

When it comes to supporting longevity and improving your body’s immune system, there’s no better time than now to take action. Today, we’re happy to announce that NNB Nutrition has just made it easier for both supplement formulators and consumers to support healthy aging and immunity with a new, pre-mixed antioxidant and superfood greens formula named MitoGreens.

MitoGreens: 30 powerhouse ingredients boosted by ergothioneine

Since the start of this decade, we’ve covered numerous superfoods and greens formulas, most targeting healthy immune function. We’ve written about dozens of capsule-based immune supplements as well. Many have been impressive, but none of them have everything we want.

MitoGreens

NNB Nutrition’s MitoGreens is an antioxidant-packed powerhouse that’s amplified with the immunity protection of ergothioneine

In response, developed a theoretical immune system supplement, covering modern concerns, filling gaps in other formulas. It can be found in our Formulator’s Corner Immunity Supplement article, but two key points we made were that:

  1. Too many immune supplements don’t include a zinc ionophore to drive zinc into cells
  2. Supplement brands aren’t leveraging the incredible power of ergothioneine.

With NNB Nutrition’s MitoGreens, we get those two benefits and far more. This is a superfood powerhouse with 29 botanicals bolstered by L-ergothioneine, the potent immunity-supporting longevity compound that many researchers believe should be classified as a vitamin.

While L-ergothioneine is sold separately as MitoPrime, MitoGreens puts it right into an antioxidant packed powerhouse for formulators to include in numerous types of supplement formulas.

It’s all covered below – and we’ll kick it off with a review of ergothioneine — but first, sign up for our NNB Nutrition and Ergothioneine news alerts:

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What’s in MitoGreens?

Before digging into ergothioneine, let’s unpack this formula, because it’s packed:

  1. Quercetin
  2. Clove extract
  3. Green tea extract
  4. Onion extract
  5. Acerola extract
  6. Mint leaf extract
  7. Rosemary extract
  8. Grape seed extract
  9. Curry extract
  10. Elderberry concentrate
  11. Mangosteen concentrate
  12. Blackcurrant extract
  13. Blueberry extract
  14. Bilberry extract
  15. Brussels sprout concentrate
  16. Broccoli sprout concentrate
  17. Apple extract
  18. Tomato concentrate
  19. Broccoli concentrate
  20. Camu camu concentrate
  21. Garlic concentrate
  22. Oregano concentrate
  23. Carrot concentrate
  24. Sweet cherry concentrate
  25. Raspberry concentrate
  26. White pepper
  27. Chokeberry concentrate
  28. Kale concentrate
  29. Blackberry concentrate
  30. Ergothioneine

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  • What is ergothioneine?

    L-Ergothioneine

    There are several reasons why so many people feel great when adding organ meats and mushrooms back to their diet. We argue that ergothioneine is a major component.

    Although it’s last on the list, the powerful L-ergothioneine compound has tremendous effects in a small form factor – and we firmly believe it’s the next generation of ingredients in both the immunity and longevity categories.

    Ergothioneine is a sulfur-containing amino acid that possesses powerful anti-inflammatory and antioxidant properties.[1,2] The human body has a highly-specific transporter system responsible for its uptake,[3-5] yet cannot synthesize the amino acid itself,[6-9] so it must be obtained exclusively from the diet.

    Considered an essential nutrient and “longevity vitamin” by experts

    Because ergothioneine can’t be produced by the body yet has so many incredible effects (many detailed below), several researchers now consider it an essential nutrient, classifying it as a “candidate vitamin”.[10,11] In fact, the prominent Dr. Bruce Ames even calls it a “longevity vitamin”.[12,13]

    Ergothioneine Benefits

    With such a massive list of benefits shown from ergothioneine, why haven’t we heard more about it? This is a must-research immune system supplement ingredient that can protect numerous organ systems.[14]

    However, it’s not a new or novel ingredient by any measure — ergothioneine has actually been protecting organisms on the planet for billions of years. Researchers have begun to determine that this powerful antioxidant actually fueled the survival of life through the Earth’s “great oxygenation event” 2.4 billion years ago![15-19] It’s made its way through our food supply primarily in mushrooms and organ meats[20-23] — two food sources that we sadly don’t eat enough of during the recent industrialization of our food supply over the past few generations.

    This presents ample opportunity for supplementation, and as shown below, providing cells ergothioneine exhibits incredible effects. Even better, our bodies are able to store ergothioneine for future use,[4,24,25] so it’s not wasted if it’s not presently needed.

    The true master antioxidant

    Many scientists and supplement experts call glutathione the “master antioxidant”. Glutathione is indeed powerful, but it turns out that when it comes to scavenging free radicals, L-ergothioneine outperforms glutathione, coenzyme Q10, and vitamin C![23,26,27]

    • Outperforming glutathione

      This has actually been known since 1988, where researchers compared ergothioneine, glutathione, and other thiols in their effects in deactivating toxic singlet oxygen.[26] Ergothioneine outperformed glutathione (and the entire group at large), stopping oxidation faster than the other compounds. The study suggested that ergothioneine was one of the most impressive skin-protective antioxidants.[26] An additional study (image below) demonstrated ergothioneine’s inhibitory effects to be superior to both glutathione and Vitamin C as well!

      Ergothioneine vs. Glutathione and Vitamin C

      Inhibitory effects of Ergothioneine vs. Glutathione, Histidine, and Vitamin C[23]

    • Outperforming CoQ10

      In 2007, researchers tested ergothioneine and CoQ10 against cells exposed to highly-toxic alloxan, and then measured lipid peroxidation. Both worked, but it turned out that ergothioneine was twice as effective as CoQ10, and on a dose-dependent basis.[27]

    • Outperforming vitamin C

      Finally, a study published in 2016 showed that ergothioneine bested vitamin C and glutathione once again, this time in combating two reactive halogen species, hypochlorous acid and hypobromous acid.[23]

    • Improved cell viability

      Inversely, research has shown that cells lacking ergothioneine transporters are far more susceptible to stress-induced oxidative damage.[24] There is a lot of research showing longevity benefits, since ergothioneine can boost cell viability by 45%,[28] preventing DNA damage and protecting red blood cells.[25]

    The next-generation Immunity supplement

    Ergothioneine Roles

    Ergothioneine serves several roles in the system, and we’re already wired for it! But are you getting any in your diet?[4]

    An incredible 2020 paper published in Antioxidants lays the evidence for ergothioneine’s role in immunity — it’s titled “Could Ergothioneine Aid in the Treatment of Coronavirus Patients?”.[14] The paper is written by researchers with vast expertise in the ingredient,[4] and shows that ergothioneine’s strengths align to combat our current immune concerns.

    Inside, the researchers cite a plethora of research showing ergothioneine’s benefits, all of which are pivotal to immune function and our modern concerns:[14]

    • Overall inflammation reduction
    • Strong ability to scavenge free radicals
    • Acute respiratory distress mitigation
    • Endothelial cell protection
    • Protection against heart disease and injury
    • Neuroprotection
    • Ability to combat iron dysregulation
    • Lung and liver disease damage reduction

    Much of the research cited is also cited here, but the researchers dig far deeper into the mechanisms, arguing for ergothioneine’s more consistent use.

    Neuroprotection

    Ergothioneine Benefits

    Ergothioneine Benefits, as provided by NNB Nutrition’s website

    Since 1966, scientists have understood that ergothioneine plays a role in central regulatory function.[29] Further research showed that it’s quite neuroprotective,[30] and can attenuate oxidative stress in neural cells and inhibit cognitive decline in animal models.[31]

    This makes sense, with research showing that humans with neurological disorders have low levels of ergothioneine,[32,33] while the ergothioneine transporter (OTCN1) is strongly expressed in the neural stem cells and gets heavy concentration in the brain once ingested.[32,34]

    Protective from other forms of biochemical stress

    Many of ergothioneine’s incredible effects are due to the fact that it can combat numerous types of stress – going well beyond reactive oxygen species (ROS).

    Research has shown the amino acid antioxidant successfully fighting the following:

    • Hydrogen peroxide induced stress[24,27,35,36]
    • Damage due to chlorine and bromine exposure[23,37]
    • Singlet oxygen[26]
    • Reactive nitrogen species[38,39]
    • General inflammatory stress[1,23,40,41]
    • Red blood cell oxidation[25]
    Ergothioneine

    Found in mushrooms and organ meats, ergothioneine is the oldest — and most overlooked — energy-supporting immune system booster / antioxidant on the market. Prepare to have your mind blown by this ingredient.

    Interestingly, human-based studies have even shown ergothioneine to work well with other common joint supplement ingredients to combat joint pain and range of motion![42]

    Available as MitoPrime, but now in MitoGreens

    The wondrous ergothioneine was first available in NNB Nutrition’s MitoPrime (and still is), but now comes packaged in a superior antioxidant greens formula that includes 29 additional botanicals – many of which are covered below. NNB has solved the problem of L-ergothioneine’s availability and stability, and is now making it easier for brands to take advantage of.

    If you wish to further research this potent ingredient, see our article titled Ergothioneine: The Immunity and Energy Protector.

  • Quercetin, Green Tea Extract, and other important polyphenols

    In our introduction, we mentioned that too many immunity supplements include a zinc ionophore alongside a high-bioavailability zinc. While there’s no added zinc to MitoGreens, they come with two powerful zinc ionophores in quercetin and green tea extract![43] These types of compounds help the body drive zinc into cells (through the plasma membrane) so that the zinc can work its antiviral effects.

    Formulator's Corner #06: A Modern Immunity Supplement

    For the sixth installment of our Formulator’s Corner series, we drafted up a powerful Immunity Supplement with modern concerns in mind — and it featured NNB Nutrition’s MitoPrime (L-Ergothioneine) along with zinc ionophore quercetin

    Knowing this, researchers have had several successful antiviral trials that utilize quercetin alongside zinc and other immunity ingredients like vitamin C (some of which will also be in MitoGreens).[44-48] Before this, quercetin was very well-known for its ability to combat allergies.[49,50] In addition, it can inhibit inflammatory cytokines and downregulate their production, helping with immune response.[50]

    Quercetin also possesses anti-aging properties as a CD38 inhibitor,[51,52] which will allow NAD+ levels to stay higher for improved cellular energy. Since the CD38 enzyme is a major consumer of NAD+ levels,[53] and CD38 goes up as NAD+ goes down as we age,[54,55] we strongly believe in using quercetin on a daily basis, and it pairs incredibly well with NAD+ booster BioNMN, NNB Nutrition’s trademarked form of NMN (nicotinamide mononucleotide).

    Beyond its position as a zinc ionophore, green tea extract is also considered the “Swiss army knife” of metabolic support ingredients, given that it can increase fat oxidation,[56] boost blood flow,[57] improve insulin sensitivity,[58,59] reduce blood pressure,[60] and generally improve well-being.[60]

    Having these two ingredients inside of MitoGreens enables formulators to build flexible anti-aging and/or immune supplements, allowing them to choose their preferred form of zinc to drive into cells.

  • Spices and herbs

    When creating MitoGreens, NNB Nutrition added some very unique components that we don’t normally see in other greens formulas. The addition of clove, rosemary, curry extract, garlic, oregano, mint, and white pepper extract lead to some effects that may not be realized by competing formulas.

    Garlic

    Garlic possesses incredible anti-parasitic effects that most don’t talk about, outperforming popular pharmaceutical drugs in certain situations

    Clove is an ingredient we don’t commonly see in dietary supplements – it’s been shown to mitigate damage from oxidative stress and liver injury by preventing cell proliferation in numerous types of cells.[61]

    Rosemary provides rosmarinic acid, which exhibits great antioxidant qualities that lead to anti-allergy effects that reduce nasal congestion.[62]

    We also added garlic into our recent hypothetical immunity formulation, discussing its potent anti-parasitic effects (outperforming popular drugs)[63] in addition to its antiviral behavior.[64,65] Oregano also has incredible anti-parasitic properties.[66]

    These are some very unique properties that aren’t expressed in most greens powders.

  • Fruits and Berries

    MitoGreens also have several well-researched fruit extracts, including acerola, grape seed, elderberry, blackcurrant, blueberry, bilberry, apple, camu camu, chokeberry, raspberry, sweet cherry, and blackberry. In general, fruits provide a broad spectrum of antioxidants that often lead to better cardiometabolic wellness and improved exercise recovery.

    To key in on a few:

    Aronia Berries

    Aronia Berries, the source of Cyanidin-3-O-Glycosides rich BrainBerry. Image courtesy Wikimedia

    • Acerola is one of the planet’s best sources of vitamin C,[67] and also has a great taste to it.
    • Grape Seed Extract is frequently used to boost blood flow, as it helps reduce blood pressure through its interactions with eNOS (endothelial nitric oxide synthase).[68]
    • Elderberry is very well-known for its effects on immunity, helping to combat numerous winter illnesses thanks to its rich antioxidant, anti-inflammatory effects.[69,70]
    • Blueberry not only helps increase recovery and lower muscle damage from training,[71] it does so through DNA protection,[72-74] which is highly relevant to MitoGreens.
    • Camu camu is a berry from the Amazon rainforest that has a unique phytochemical profile with strong anti-aging, antioxidant properties.[75]
    • Chokeberry, also known as Baltic Aronia Berry (or Aronia melanocarpa) has received a lot of attention due to its constituent Cyanidin-3-Galactoside, which has many neuroprotective properties.[76,77]
  • See the image below to grasp how powerful the chokeberry is:

    Cyanidin 3-O-Galactoside

    Don’t underestimate the incredible power of cyanidin 3-O-galactoside found in chokeberry / Aronia melanocarpa / Baltic Aronia Berry)[77]

  • Vegetable Support

    Finally, MitoGreens also contains many popular vegetables, including onion, brussels sprouts, broccoli and broccoli sprouts, and kale.

    The mitochondria are the powerhouses of our cells. But how do they work, how is our food supply damaging them so badly, and what can we do to fix the issue? Prepare to meet the Power of Mito, presented by NNB Nutrition.

    • Onions don’t get used in supplements too often, but they’re known to be great sources of quercetin[78,79] (covered above) as well as other flavonoids and the alk(en)yl cysteine sulfoxides (ACSOs).[80]
    • Brussels sprouts are glucosinolate-containing cruciferous vegetables that can boost glutathione content in the intestines, leading to enhanced detoxification enzyme levels.[81]
    • Broccoli is another well-known cruciferous vegetable that has several constituents providing a great deal of vitamins and minerals.[82] More importantly, young broccoli sprouts contain sulforaphane, which has been shown to be instrumental in combating disease.[83]
    • Kale is the popular leafy green that has excellent antioxidant activity and may provide some gut health protection as well.[84]

MitoGreens Complete Formula

NNB Nutrition

NNB Nutrition is an innovative ingredient development company with an elite team of over 100 scientists from over 10 countries.

All combined, MitoGreens is a superfood powerhouse combined to support healthy aging, cognitive function, natural energy levels, cardiometabolic support, and joint health. It’s non-GMO and gluten-free, and can be dosed as low as 200 milligrams per day.

With an extremely high ORAC (Oxygen Radical Absorbance Capacity) level, amplified by the immense benefits of ergothioneine and bolstered by quercetin, MitoGreens can single-handedly take any supplement to the next level, whether it’s a greens powder, multivitamin, anti-aging supplement, or natural energy product.

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MitoGreens: Ergothioneine-Amplified Antioxidant Blend by NNB Nutrition

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

  1. Rahman, Irfan, et al; “Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells”; Biochemical and Biophysical Research Communications; Volume 302, Issue 4, Pages 860-864; 21 March 2003; https://www.sciencedirect.com/science/article/abs/pii/S0006291X03002249
  2. Deiana, Monica, et al. “L-Ergothioneine Modulates Oxidative Damage in the Kidney and Liver of Rats in Vivo: Studies upon the Profile of Polyunsaturated Fatty Acids.” Clinical Nutrition (Edinburgh, Scotland), vol. 23, no. 2, 1 Apr. 2004, pp. 183–193, 10.1016/S0261-5614(03)00108-0; https://pubmed.ncbi.nlm.nih.gov/15030958/
  3. Gründemann, Dirk, et al; “Discovery of the Ergothioneine Transporter.”; PNAS; National Academy of Sciences; 5 Apr. 2005; https://www.pnas.org/content/102/14/5256
  4. Cheah, Irwin K, and Barry Halliwell; “Ergothioneine; Antioxidant Potential, Physiological Function and Role in Disease.”; Biochimica Et Biophysica Acta; U.S. National Library of Medicine; May 2012; https://www.sciencedirect.com/science/article/pii/S0925443911002201
  5. Nakamura, Toshimichi, et al. “Functional Characterization of Ergothioneine Transport by Rat Organic Cation/Carnitine Transporter Octn1 (Slc22a4).” Biological & Pharmaceutical Bulletin, vol. 31, no. 8, 2008, pp. 1580–1584, 10.1248/bpb.31.1580; https://pubmed.ncbi.nlm.nih.gov/18670092/
  6. Eagles, Blythe Alfred, Vars, Harry M; “The Physiology of Ergothioneine”; The Journal of Biological Chemistry; 80, 615-622; December 1, 1928; https://www.jbc.org/content/80/2/615.long
  7. Melville, Donald, Horner, William, and Lubschez, Rose; “Tissue Ergothioneine”; The Journal of Biological Chemistry; 206, 221-228; January 1, 1954; https://www.jbc.org/content/206/1/221.long
  8. Melville, Donald, et al; “On the Origin of Animal Ergothioneine”; The Journal of Biological Chemistry; 216, 325-331; September 1, 1955; https://www.jbc.org/content/216/1/325.long
  9. Melville, Donald, et al; “The Occurrence of Ergothioneine in Plant Material”; The Journal of Biological Chemistry; 218, 647-651; February 1, 1957; https://www.jbc.org/content/218/2/647.long
  10. Stoffels, Christopher, et al; “Ergothioneine stands out from hercynine in the reaction with singlet oxygen: Resistance to glutathione and TRIS in the generation of specific products indicates high reactivity”; Free Radical Biology and Medicine; Volume 113, Pages 385-394; December 2017; https://www.sciencedirect.com/science/article/abs/pii/S0891584917311553
  11. University of Basel; “The vitamin ergothioneine—an antioxidant for oxygen-free areas?”; October 4, 2017; https://phys.org/news/2017-10-vitamin-ergothioneinean-antioxidant-oxygen-free-areas.html
  12. Ames, Bruce N. “Prolonging healthy aging: Longevity vitamins and proteins.” Proceedings of the National Academy of Sciences of the United States of America vol. 115,43 (2018): 10836-10844. doi:10.1073/pnas.1809045115; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205492/
  13. Beelman, Robert B., et al. “Is Ergothioneine a ‘Longevity Vitamin’ Limited in the American Diet?” Journal of Nutritional Science, vol. 9, 2020, 10.1017/jns.2020.44; https://www.cambridge.org/core/journals/journal-of-nutritional-science/article/is-ergothioneine-a-longevity-vitamin-limited-in-the-american-diet/31B9A91CEB3A61C8F72CCFD56B85704E
  14. Cheah, Irwin K, and Barry Halliwell. “Could Ergothioneine Aid in the Treatment of Coronavirus Patients?.” Antioxidants (Basel, Switzerland) vol. 9,7 595. 7 Jul. 2020, doi:10.3390/antiox9070595; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402156/
  15. Burn, Reto, et al; “Anaerobic Origin of Ergothioneine”; Angewandte Chemie; Volume 129, Issue 41; Pages 12682-12685; October 2, 2017; https://onlinelibrary.wiley.com/doi/abs/10.1002/ange.201705932
  16. Valachová, Katarína, et al; “The importance of ergothioneine synthesis in ancient time by organisms living in oxygen free atmosphere”; Medical Hypotheses; Volume 123, Pages 72-73; February 2019; https://www.sciencedirect.com/science/article/abs/pii/S0306987718311186
  17. Mark W. Ruszczycky, et al; “The surprising history of an antioxidant”; Nature; 551, pages 37–38; 2017; https://www.nature.com/articles/551037a
  18. University of Basel; “The vitamin ergothioneine—an antioxidant for oxygen-free areas?”; October 4, 2017; https://phys.org/news/2017-10-vitamin-ergothioneinean-antioxidant-oxygen-free-areas.html
  19. Mark W. Ruszczycky, et al; “The surprising history of an antioxidant”; Nature; 551, pages 37–38; 2017; https://www.nature.com/articles/551037a
  20. Janine Ey, Edgar Schömig, and Dirk Taubert; “Dietary Sources and Antioxidant Effects of Ergothioneine.”; Dietary Sources and Antioxidant Effects of Ergothioneine; Journal of Agricultural and Food Chemistry; https://pubs.acs.org/doi/10.1021/jf071328f
  21. Dubost, et al; “Identification and Quantification of Ergothioneine in Cultivated Mushrooms by Liquid Chromatography-Mass Spectroscopy”; International Journal of Medicinal Mushrooms; 8(3):215-222; January 2006; https://www.researchgate.net/publication/270471344_Identification_and_Quantification_of_Ergothioneine_in_Cultivated_Mushrooms_by_Liquid_Chromatography-Mass_Spectroscopy
  22. Beelman, Robert; “Ergothioneine in Mushrooms-Nature’s Best Source of a New Human Vitamin?”; Penn State University; https://web.archive.org/web/20171028014650/https://plantpath.psu.edu/mushroom-industry-conference/52-mushroom-industry-conference/Bob%20Beelman.pdf
  23. Asahi, T, et al; “A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation”; Bioscience, Biotechnology, and Biochemistry; 80(2):313-7; 2016; https://www.tandfonline.com/doi/full/10.1080/09168451.2015.1083396
  24. Paul, B D, and S H Snyder; “The unusual amino acid L-ergothioneine is a physiologic cytoprotectant.”; Cell death and differentiation; vol. 17,7; 2010; 1134-40; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885499/
  25. Evans, Joseph L; “Report 174-001. Foundational properties at the cellular level.”; NIS Labs; May 7, 2021; https://blog.priceplow.com/wp-content/uploads/nnb-ergothioneine-report-114-001-in_vitro_testing-20210507.pdf
  26. Rougee, M., et al; “Deactivation of Singlet Molecular Oxygen by Thiols and Related Compounds, Possible Protectors Against Skin Photosensitivity”; Photochemistry and Photobiology; Volume 47, Issue 4; April 1988; https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1751-1097.1988.tb08835.x
  27. Dong KK, Damaghi N, Kibitel J, Canning MT, Smiles KA, Yarosh DBl; “A comparison of the relative antioxidant potency of L‐ergothioneine and idebenone”; Journal of Cosmetic Dermatology; Volume 6, Issue 3, Pages 183-188; September 2007; https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1473-2165.2007.00330.x
  28. Jang, Jung-Hee, et al; “Ergothioneine Rescues PC12 Cells from Beta-Amyloid-Induced Apoptotic Death.”; Free Radical Biology & Medicine; U.S. National Library of Medicine; 1 Feb. 2004; https://pubmed.ncbi.nlm.nih.gov/15036348
  29. Crossland, J., et al. “The Presence of Ergothioneine in the Central Nervous System and Its Probable Identity with the Cerebellar Factor.” The Journal of Physiology, vol. 182, no. 2, 1 Jan. 1966, p. 427, 10.1113/jphysiol.1966.sp007830; https://www.ncbi.nlm.nih.gov/sites/ppmc/articles/PMC1357478/
  30. Moncaster, Juliet A, et al. “Ergothioneine Treatment Protects Neurons against N-Methyl-d-Aspartate Excitotoxicity in an in Vivo Rat Retinal Model.” Neuroscience Letters, vol. 328, no. 1, 2 Aug. 2002, pp. 55–59, 10.1016/S0304-3940(02)00427-5; https://www.sciencedirect.com/science/article/abs/pii/S0304394002004275
  31. Song, T-Y, et al; “Ergothioneine and Melatonin Attenuate Oxidative Stress and Protect against Learning and Memory Deficits in C57BL/6J Mice Treated with D-Galactose”; Free Radical Research; U.S. National Library of Medicine; Sept. 2014; https://pubmed.ncbi.nlm.nih.gov/24797165
  32. Cheah, Irwin K, et al; “Ergothioneine Levels in an Elderly Population Decrease with Age and Incidence of Cognitive Decline; a Risk Factor for Neurodegeneration?”; Biochemical and Biophysical Research Communications; U.S. National Library of Medicine; 9 Sept. 2016; https://pubmed.ncbi.nlm.nih.gov/27444382
  33. Hatano, Taku, et al; “Identification of Novel Biomarkers for Parkinson’s Disease by Metabolomic Technologies.”; Journal of Neurology, Neurosurgery, and Psychiatry; U.S. National Library of Medicine; March 2016; https://pubmed.ncbi.nlm.nih.gov/25795009
  34. Nakamichi, Noritaka, and Yukio Kato; “Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells.”; Biological & Pharmaceutical Bulletin; U.S. National Library of Medicine; 2017; https://pubmed.ncbi.nlm.nih.gov/28768995
  35. Dong, Kelly, et al; “L-ergothioneine reduces UVA340-induced hydrogen peroxide in fibroblasts more efficiently than idebenone”; Journal of American Academy of Dermatology; Volume 56, Issue 2, Supplement 2, Page AB86; February 2007; https://www.jaad.org/article/S0190-9622(06)03265-8/fulltext
  36. Colognato, R, et al; “Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine”; Clinical Nutrition; 25(1):135-45; February 2006; https://pubmed.ncbi.nlm.nih.gov/16314005
  37. Akanmu, D, et al; “The antioxidant action of ergothioneine”; Archives of Biochemistry and Biophysics; 288(1):10-6; July 1991; https://pubmed.ncbi.nlm.nih.gov/1654816
  38. Aruoma, Ol, et al; “Antioxidant action of ergothioneine: assessment of its ability to scavenge peroxynitrite”; Biochemical and Biophysical Research Communications; 231(2):389-91; February 13, 1997; https://pubmed.ncbi.nlm.nih.gov/9070285
  39. Franzoni, F, et al; “An in vitro study on the free radical scavenging capacity of ergothioneine: comparison with reduced glutathione, uric acid and trolox”; Biomedical & Pharmacotherapy; 60(8):453-7; September 2006; https://pubmed.ncbi.nlm.nih.gov/16930933
  40. Incoronata Laurenza, et al; “Modulation of palmitic acid‐induced cell death by ergothioneine: Evidence of an anti‐inflammatory action”; BioFactors; Volume 33, Issue 4; August 19, 2009; https://iubmb.onlinelibrary.wiley.com/doi/abs/10.1002/biof.5520330401
  41. Song, Tuzz-Ying et al; “Protective Effects and Possible Mechanisms of Ergothioneine and Hispidin against Methylglyoxal-Induced Injuries in Rat Pheochromocytoma Cells”; Oxidative Medicine and Cellular Longevity; vol. 2017: 4824371; October 17, 2017; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5664345/
  42. Benson, Kathleen F., et al. “Improvement of Joint Range of Motion (ROM) and Reduction of Chronic Pain after Consumption of an Ergothioneine-Containing Nutritional Supplement.” Preventive Medicine, vol. 54, May 2012, pp. S83–S89, 10.1016/j.ypmed.2012.02.001; https://pubmed.ncbi.nlm.nih.gov/22342951/
  43. Husam Dabbagh-Bazarbachi, Gael Clergeaud, Isabel M. Quesada, Mayreli Ortiz, Ciara K. O’Sullivan, and Juan B. Fernández-Larrea; Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model”; Journal of Agricultural and Food Chemistry; 2014; 62 (32), 8085-8093; https://pubs.acs.org/doi/10.1021/jf5014633
  44. Arslan, Bengu, et al. “Synergistic Effect of Quercetin and Vitamin C against COVID-19: Is a Possible Guard for Front Liner.” Europe PMC, 2020; https://europepmc.org/article/ppr/ppr239932
  45. Di Pierro, Francesco, et al. “Possible Therapeutic Effects of Adjuvant Quercetin Supplementation against Early-Stage COVID-19 Infection: A Prospective, Randomized, Controlled, and Open-Label Study.” International Journal of General Medicine, vol. Volume 14, June 2021, pp. 2359–2366, 10.2147/ijgm.s318720; https://www.dovepress.com/possible-therapeutic-effects-of-adjuvant-quercetin-supplementation-aga-peer-reviewed-fulltext-article-IJGM
  46. Di Pierro, Francesco, et al. “Potential Clinical Benefits of Quercetin in the Early Stage of COVID-19: Results of a Second, Pilot, Randomized, Controlled and Open-Label Clinical Trial.” International Journal of General Medicine, vol. Volume 14, June 2021, pp. 2807–2816, 10.2147/ijgm.s318949; https://www.dovepress.com/potential-clinical-benefits-of-quercetin-in-the-early-stage-of-covid-1-peer-reviewed-fulltext-article-IJGM
  47. Margolin, Leon, et al. “20-Week Study of Clinical Outcomes of Over-The-Counter COVID-19 Prophylaxis and Treatment.” Journal of Evidence-Based Integrative Medicine, vol. 26, 1 Jan. 2021, p. 2515690X2110261, 10.1177/2515690×211026193; https://journals.sagepub.com/doi/full/10.1177/2515690X211026193
  48. Colunga Biancatelli RML, Berrill M, Catravas JD and Marik PE; “Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)”; Front. Immunol. 11:1451; 2020; doi: 10.3389/fimmu.2020.01451; https://www.frontiersin.org/articles/10.3389/fimmu.2020.01451/full
  49. Li, Y. et al. Mar. 2016. “Quercetin, Inflammation and Immunity.” Nutrients vol. 8,3; 167. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/
  50. Mlcek, J. et al. May 2016. “Quercetin and Its Anti-Allergic Immune Response.” Molecules vol. 21,5; 623. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6273625/
  51. Escande, Carlos et al; “Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome”; Diabetes; vol. 62,4 (2013): 1084-93; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609577/
  52. Kellenberger E, Kuhn I, Schuber F, Muller-Steffner H; “Flavonoids as inhibitors of human CD38”; Bioorg Med Chem Lett; 2011 Jul 1; 21(13):3939-42; https://pubmed.ncbi.nlm.nih.gov/21641214/
  53. Sinclair, David, Chwalek, K, Rajman, L; “Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence”; Cell Metabolism; Volume 27, Issue 3, P529-547, March 6, 2018; https://www.cell.com/cell-metabolism/comments/S1550-4131(18)30122-0
  54. Aksoy P, Escande C, White TA, Thompson M, Soares S, Benech JC, Chini EN; “Regulation of SIRT 1 mediated NAD dependent deacetylation: a novel role for the multifunctional enzyme CD38”; Biochem Biophys Res Commun; 2006 Oct 13;349(1):353-9; doi: 10.1016/j.bbrc.2006.08.066; https://pubmed.ncbi.nlm.nih.gov/16935261/
  55. Camacho-Pereira, Juliana, et al; “CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism”; Cell Metabolism; https://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30224-8
  56. Hursel, R., et al. “The Effects of Catechin Rich Teas and Caffeine on Energy Expenditure and Fat Oxidation: A Meta-Analysis.” Obesity Reviews, vol. 12, no. 7, 2 Mar. 2011, pp. e573–e581, 10.1111/j.1467-789x.2011.00862.x; https://onlinelibrary.wiley.com/doi/full/10.1111/j.1467-789X.2011.00862.x
  57. Ras, Rouyanne T., et al. “Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis.” PLoS ONE, vol. 6, no. 3, 4 Mar. 2011, p. e16974, 10.1371/journal.pone.0016974; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048861/
  58. Hsu, Chung-Hua, et al. “Does Supplementation with Green Tea Extract Improve Insulin Resistance in Obese Type 2 Diabetics? A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial.” Alternative Medicine Review: A Journal of Clinical Therapeutic, vol. 16, no. 2, 1 June 2011, pp. 157–163; https://pubmed.ncbi.nlm.nih.gov/21649457/ ( full text PDF)
  59. Venables, Michelle C, et al. “Green Tea Extract Ingestion, Fat Oxidation, and Glucose Tolerance in Healthy Humans.” The American Journal of Clinical Nutrition, vol. 87, no. 3, 1 Mar. 2008, pp. 778–784, 10.1093/ajcn/87.3.778; https://academic.oup.com/ajcn/article/87/3/778/4633440
  60. Brown, A. Louise, et al. “Effects of Dietary Supplementation with the Green Tea Polyphenol Epigallocatechin-3-Gallate on Insulin Resistance and Associated Metabolic Risk Factors: Randomized Controlled Trial.” British Journal of Nutrition, vol. 101, no. 6, 19 Aug. 2008, pp. 886–894, 10.1017/s0007114508047727; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819662/
  61. Abdelrahman, Mohamad T., et al. “Clove (Syzygium Aromaticum) and Honey Extracts Significantly Reduce Inflammatory Cytokines and Liver Function Enzymes in Experimental Rats Fed on Carbon Tetrachloride (CCl4).” Journal of Radiation Research and Applied Sciences, vol. 11, no. 4, Oct. 2018, pp. 416–422, 10.1016/j.jrras.2018.08.003; https://www.sciencedirect.com/science/article/pii/S1687850718300542
  62. Takano, Hirohisa, et al. “Extract of Perilla Frutescens Enriched for Rosmarinic Acid, a Polyphenolic Phytochemical, Inhibits Seasonal Allergic Rhinoconjunctivitis in Humans.” Experimental Biology and Medicine (Maywood, N.J.), vol. 229, no. 3, 1 Mar. 2004, pp. 247–254, 10.1177/153537020422900305; https://pubmed.ncbi.nlm.nih.gov/14988517/
  63. Ayaz, Erol, et al. “Evaluation of the Anthelmentic Activity of Garlic (Allium Sativum) in Mice Naturally Infected with Aspiculuris Tetraptera.” Recent Patents on Anti-Infective Drug Discovery, vol. 3, no. 2, 1 June 2008, pp. 149–152, 10.2174/157489108784746605; https://pubmed.ncbi.nlm.nih.gov/18673129/
  64. Mohajer Shojai, Tabassom, et al. “The Effect of Allium Sativum (Garlic) Extract on Infectious Bronchitis Virus in Specific Pathogen Free Embryonic Egg.” Avicenna Journal of Phytomedicine, vol. 6, no. 4, 2016, pp. 458–267; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967842/
  65. Thuy, Bui Thi Phuong, et al. “Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil.” ACS Omega, vol. 5, no. 14, 31 Mar. 2020, pp. 8312–8320, 10.1021/acsomega.0c00772; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7123907/
  66. Force, M., et al. “Inhibition of Enteric Parasites by Emulsified Oil of Oregano in Vivo.” Phytotherapy Research: PTR, vol. 14, no. 3, 1 May 2000, pp. 213–214, 3.0.co;2-u”>10.1002/(sici)1099-1573(200005)14:3<213::aid-ptr583>3.0.co;2-u; https://pubmed.ncbi.nlm.nih.gov/10815019/
  67. Cefali, Letícia Caramori, et al; “Vitamin C in Acerola and Red Plum Extracts: Quantification via HPLC, in Vitro Antioxidant Activity, and Stability of Their Gel and Emulsion Formulations.”; Journal of AOAC International; U.S. National Library of Medicine; 1 Sept. 2018; https://www.ncbi.nlm.nih.gov/pubmed/29895343
  68. Zhang, Haili, et al. “The Impact of Grape Seed Extract Treatment on Blood Pressure Changes.” Medicine, vol. 95, no. 33, 19 Aug. 2016, 10.1097/MD.0000000000004247. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370781/
  69. Ulbricht, C. et al; “An Evidence-Based Systematic Review of Elderberry and Elderflower (Sambucus nigra) by the Natural Standard Research Collaboration”; Journal of Dietary Supplements; 2014; 11(1), 80–120; https://www.ncbi.nlm.nih.gov/pubmed/24409980
  70. Barak V., et al; “The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines”; Eur Cytokine Netw. 2001 Apr-Jun;12(2):290-6; https://www.ncbi.nlm.nih.gov/pubmed/11399518
  71. McLeay, Yanita, et al. “Effect of New Zealand Blueberry Consumption on Recovery from Eccentric Exercise-Induced Muscle Damage.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 2012, p. 19, 10.1186/1550-2783-9-19; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3583121/
  72. Wilms, Lonneke C., et al. “Impact of Multiple Genetic Polymorphisms on Effects of a 4-Week Blueberry Juice Intervention on Ex Vivo Induced Lymphocytic DNA Damage in Human Volunteers.” Carcinogenesis, vol. 28, no. 8, 1 Aug. 2007, pp. 1800–1806, 10.1093/carcin/bgm145; https://academic.oup.com/carcin/article/28/8/1800/2526773
  73. Del Bo′, Cristian, et al. “A Single Portion of Blueberry (Vaccinium Corymbosum L) Improves Protection against DNA Damage but Not Vascular Function in Healthy Male Volunteers.” Nutrition Research, vol. 33, no. 3, Mar. 2013, pp. 220–227, 10.1016/j.nutres.2012.12.009; https://pubmed.ncbi.nlm.nih.gov/23507228/
  74. Riso, Patrizia, et al. “Effect of a Wild Blueberry (Vaccinium Angustifolium) Drink Intervention on Markers of Oxidative Stress, Inflammation and Endothelial Function in Humans with Cardiovascular Risk Factors.” European Journal of Nutrition, vol. 52, no. 3, 1 Apr. 2013, pp. 949–961, 10.1007/s00394-012-0402-9; https://pubmed.ncbi.nlm.nih.gov/22733001/
  75. Langley, Paul C., et al. “Antioxidant and Associated Capacities of Camu Camu (Myrciaria Dubia): A Systematic Review.” Journal of Alternative and Complementary Medicine, vol. 21, no. 1, 1 Jan. 2015, p. 8, 10.1089/acm.2014.0130; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4296744/
  76. Tan, Long, et al. “Cyanidin-3-O-Galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-Accelerated Mice.” Biomedical and Environmental Sciences: BES, vol. 27, no. 3, 1 Mar. 2014, pp. 186–196, 10.3967/bes2014.007; https://pubmed.ncbi.nlm.nih.gov/24709099/
  77. Liang, Zhongxin, et al. “Cyanidin 3-O-Galactoside: A Natural Compound with Multiple Health Benefits.” International Journal of Molecular Sciences, vol. 22, no. 5, 1 Mar. 2021, 10.3390/ijms22052261; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7956414/
  78. Yoo, Kil Sun, et al. “Quantification of Quercetin Glycosides in 6 Onion Cultivars and Comparisons of Hydrolysis-HPLC and Spectrophotometric Methods in Measuring Total Quercetin Concentrations.” Journal of Food Science, vol. 75, no. 2, 1 Mar. 2010, pp. C160-165, 10.1111/j.1750-3841.2009.01469.x; https://pubmed.ncbi.nlm.nih.gov/20492220/
  79. Arabbi, Paola R., et al. “Flavonoids in Vegetable Foods Commonly Consumed in Brazil and Estimated Ingestion by the Brazilian Population.” Journal of Agricultural and Food Chemistry, vol. 52, no. 5, 10 Mar. 2004, pp. 1124–1131, 10.1021/jf0499525; https://pubmed.ncbi.nlm.nih.gov/14995109/
  80. Griffiths, Gareth, et al. “Onions? A Global Benefit to Health.” Phytotherapy Research, vol. 16, no. 7, 2002, pp. 603–615, 10.1002/ptr.1222; https://pubmed.ncbi.nlm.nih.gov/12410539/
  81. Nijhoff, W. A., et al. “Effects of Consumption of Brussels Sprouts on Intestinal and Lymphocytic Glutathione S-Transferases in Humans.” Carcinogenesis, vol. 16, no. 9, 1 Sept. 1995, pp. 2125–2128, 10.1093/carcin/16.9.2125; https://pubmed.ncbi.nlm.nih.gov/7554064/
  82. Vasanthi, Hannah, et al. “Potential Health Benefits of Broccoli- a Chemico-Biological Overview.” Mini-Reviews in Medicinal Chemistry, vol. 9, no. 6, 1 June 2009, pp. 749–759, 10.2174/138955709788452685; https://pubmed.ncbi.nlm.nih.gov/19519500/
  83. Yagishita, Yoko, et al. “Broccoli or Sulforaphane: Is It the Source or Dose That Matters?” Molecules, vol. 24, no. 19, 6 Oct. 2019, 10.3390/molecules24193593; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804255/
  84. Šamec, Dunja, et al. “Kale (Brassica Oleracea Var. Acephala) as a Superfood: Review of the Scientific Evidence behind the Statement.” Critical Reviews in Food Science and Nutrition, vol. 59, no. 15, 24 Apr. 2018, pp. 2411–2422, 10.1080/10408398.2018.1454400; https://pubmed.ncbi.nlm.nih.gov/29557674/

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