PEScience Omnizen: An All-Powerful Mood Booster!

For many of us, life is pretty rapid-fire; we need to balance work, family life, and errands, hopefully while sneaking in a workout somewhere! This pace often throws us into a whirlwind, messing up our mood and the hormonal mechanisms that control them. Practices such as mindfulness or meditation are constantly shared with the hopes of improving one’s mood. Sometimes, however, stress is more physical than that, and a quick breathing exercise just might not be enough.

Get Zen: Omnizen. Full-Spectrum Mood & Stress Support

PEScience has been around for quite some time, and have proudly entrenched themselves among the leading companies within the supplement industry. Their reputation is exceptional – each product they release is excellently formulated, science-backed, and effective, accompanied by a touch of eccentricity tied to it. While their energy formulas and proteins are impressive (such as their new Alphamine Capsules and Cake Pop flavor of Select Protein), they’ve recently decided to dive into more body and mind health with products such as Symbiont GI and TruNeuro.

Think Zen: The PEScience Omnizen Mood Enhancer

Beyond the athletic and cognitive supplements, the brand is also entering the massive market for mood-boosting supplements. Luckily for us, in PEScience Omnizen, they’re living up to their reputation, truly offering something special. This comprehensive, multi-branched mood-enhancer separates itself by working in a variety of ways, ultimately leading to a healthier overall well-being! Say goodbye to frantic stressing and overthinking, and welcome in a peaceful zen!

PEScience

See our PEScience page to compare prices on all of their excellent supplements!

In this post, we’re going to take a deep dive into Omnizen, covering every ingredient used to deliver that relaxed state we all desire. We’ll also cover the advantages this offers versus other options out there that claim to have similar effects, while maybe even dispelling some of those assertions. But, before we get into all of that, be sure to subscribe to PricePlow for all of the supplement news, reviews, deals, and diet information you could ever want!

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So, what exactly does being “stressed out” do to us?

Before you start taking a formula to combat the symptoms of stress, it’s important you know what stress is and can do in the first place!

PEScience Omnizen

Omnizen features Full-Spectrum Mood & Stress Support to get you where you need to go… calmly

Our hormones, which are excreted by a series of glands collectively referred to as the “endocrine system”, help regulate virtually every bodily process you could think of. Each specific gland controls a particular set of hormones, which in turn serve distinct purposes. The adrenal glands, which are located on the top of each kidney, regulate the body’s metabolism, immune system, and responses to stress.[1]

Signaling cortisol

Although the body is a fine-tuned machine, things can get out of whack sometimes. Life happens, and how we respond to various inconveniences has a massive effect on our adrenal glands. When something “stresses us out”, our pituitary gland signals our adrenals to produce cortisol – the hormone that controls stress.[1] Despite getting a bad rap, cortisol is actually pretty essential. It controls how we use macronutrients (proteins, fats, and carbohydrates), regulates blood pressure, controls blood glucose levels, and regulates sleeping patterns.[1] Pretty influential right? That’s exactly why things can get so problematic when it’s out of sync.

Unbalanced cortisol leads to serious issues

Cortisol helps trigger the “fight-or-flight” response to perceived dangers,[2] by way of increasing levels of the hormone. When we produce too much cortisol, some nasty things can happen, such as weight gain,[2] high blood pressure,[1] reduced insulin sensitivty,[3] poor mood, and loss of sleep. Alternatively, even lack of sufficient cortisol is problematic, leading to tiredness,[2] nausea,[2] persistent pain,[2] and weight loss[2]. As you can see, it’s crucial that we maintain optimal cortisol levels, which is much easier said than done. Most people tend to have issues with high levels of the hormone, which is where most mood-enhancers, such as Omnizen, come into play!

PEScience Omnizen Ingredients

Let’s get into the formula, breaking down what you’re getting in each three capsule serving of Omnizen!

  • Lemon Balm Extract – 600mg

    The PEScience Omnizen Ingredients, featuring clinical doses of all ingredients that can be spaced about the day. We’d reserve at least one of the three capsules for bedtime!

    Also called Melissa officinalis, lemon balm extract touts a strong reputation as both a nootropic and a sleep aid. This herb has been used for years to treat a wide variety of issues, and has proven to be very effective.

    Reduces stress and improves calmness

    In research from 2004, scientists were interested in how effective lemon balm extract was in treating symptoms of stress. Subjects were either administered a 300mg dose, a 600mg dose, or a placebo, and were tested after an hour for stress indicators and cognitive performance. They found that 600mg significantly increased overall calmness, while reducing subjects’ sense of alertness.[4] Interestingly, the 300mg group actually felt slightly more alert, suggesting a potential dose-dependent relationship.

    Research has actually concluded that last point, too. Another study administered various dosages (300mg, 600mg, or 900mg) of lemon balm in order to compare its effects. Indeed, increased calmness was felt even at the smallest dose, while alertness decreased with the highest dosage.[5] Those anecdotal sedative effects seem to be legitimate, but only when you take a large amount of this stuff!

    Reduces symptoms of anxiety

    Lemon balm may even be able to help combat anxiety, a disorder that is unfortunately common nowadays. When we start to feel anxious, our brains begin firing off brain waves at an elevated rate,[6] leading to that “overwhelmed”, anxious state of mind. Specifically, beta waves are known to associate with anxiety, whereas alpha waves lead to a more calmed headspace.[7]

    Research has shown that lemon balm extract is capable of lowering beta brain waves,[6] which can significantly reduce feelings of anxiety.[6] From a scientific standpoint, this is definitely promising, but what about its effects in vivo?

    Lemon Balm Effects

    A massive reduction in symptoms of anxiety![8]

    In 2011, 20 subjects with diagnosed anxiety and anxiety-induced insomnia were treated with 600mg of lemon balm daily for 15 days. A variety of anxiety-linked symptoms were then tested for potential improvement. At the end of the administration period, the researchers saw a 15% reduction in anxiety-related symptoms, a 42% reduction in insomnia, and a 95% improvement in all test subjects![8] To take it even further, 70% of subjects were declared for full remission from anxiety and insomnia.[8] Virtually everyone that participated in this research lowered their feelings of anxiety, and even started to sleep better, too!

    All that and a bit of memory-enhancement, too?

    Lemon balm extract seems to be quite effective in improving your memory, too. Multiple studies note that 600mg of lemon balm can improve quality of memory and enhance memory retention.[9] While this isn’t necessarily within the scope of this product specifically, it’s still worth noting. That way, if you find that you’re slightly less forgetful after supplementing with this stuff, you’ll know why!

    Coming in at 600mg, Omnizen packs the exact same lemon balm punch typically seen in research. This clinical dose should have you well on your way to feeling more relaxed, less stressed, and more peaceful!

  • KSM-66Ⓡ Ashwagandha Extract (Root) – 600mg

    Ashwagandha, sometimes referred to as Withania somnifera, is an adaptogenic herb with a deep history in Ayurvedic medicine. Anecdotally, it’s been used to treat a variety of things, but PEScience utilizes it here for perhaps its most effective ability – reducing cortisol.

    Keeps cortisol levels balanced

    We’ve already discussed the problems you can have when cortisol levels fluctuate and get out of hand. But, in order to make sure that doesn’t happen, we can employ something like ashwagandha to help us out.

    Withania Somnifera Reduces Anxiety

    Ashwagandha (blue line) reduces anxiety quickly and dramatically, especially when combined with relaxation techniques (pink control line).

    In 2012, 64 people with chronic stress were studied in order to unveil potential uses for ashwagandha. They were either administered 600mg of the herb or a placebo, daily, for a 60 day period. Upon conclusion, scientists found that those who had been given ashwagandha had significantly reduced levels of stress in all stress-assessment scales, as well as reduced serum cortisol levels.[10] By all accounts, ashwagandha helped relieve stress, and promote hormonal balance!

    It’s important to note that optimal cortisol levels hold quite a bit of weight in regards to balancing your overall hormonal state. Having too much cortisol has also been shown to lower testosterone production, especially problematic for men looking to build/maintain muscle. So, it makes sense that ashwagandha can increase testosterone production through decreasing cortisol.[11,12,13]

    Improves mood

    Not only does this adaptogen fight high cortisol levels, but it can help combat anxiety, as well! Research from 2000 identified a notable reduction of symptoms linked to anxiety after 6 weeks of treatment, in which patients received 500mg of ashwagandha daily.[14] Considering the biomechanics at play here, an ability to enhance both cortisol levels and mood makes a ton of sense!

    PEScience uses top-notch extracts

    KSM-66

    KSM-66 bills itself as the World’ Best Ashwagandha… and we don’t disagree!

    It’s important we highlight that these studies all use high-quality, standardized extracts of ashwagandha for their research. That’s relevant, considering that ashwagandha seems to draw its abilities from its concentration of withanolides, which are naturally-occurring steroids contained within the plant.[15] Without the proper extract, you won’t get the proper results.

    Thankfully, there’s no need to worry about any of that here. PEScience is using KSM-66Ⓡ, arguably the best ashwagandha extract available. It’s a full-spectrum extract derived from the plant’s root, which allows it to achieve maximum effectiveness.[16] In fact its quality is so high that KSM-66Ⓡ is often the form of ashwagandha used in research.

    As per usual, PEScience doesn’t try to cut any corners with the ingredients it uses. They only use the best of the best, and that’s something we consistently commend them for!

  • Theanine – 200mg

    Theanine is an amino acid typically derived from green tea, and is commonly used to help induce relaxation. Its been shown to help regulate important neurotransmitters within the central nervous system – dopamine, serotonin, glycine, and GABA.[17] It’s through these neurotransmitters that theanine actually gets involved here, helping out the other ingredients in Omnizen.

    L-Theanine Tea

    L-Theanine comes from tea leaves, and often helps offset anxiety.

    While lemon balm may have a sedating effect that accompanies its ability to help you relax, theanine has shown an ability to relax without signs of sedation.[18] This stuff shouldn’t affect your alertness at all; instead, it’s here to simply help you “chill out”.

    That being said, there’s some research out there suggesting it can do more than just that. A study from 2011 found that a daily dose of 400mg of theanine was able to reduce symptoms of anxiety, in schizophrenic patients, over the course of 8 weeks.[19] As encouraging as that may be, there’s actually more research suggest that theanine has no effect on anxiety.[18,20]

    Taking this before bed may be beneficial…

    Theanine has shown some promise in sleep-related research, as well. One study administered 400mg/day to young male children with ADHD, and found increased sleep quality and sleep efficiency.[21] This test group is rather specific, however, and we’d prefer to see more research relating theanine and sleep before we jump to any conclusions.

    Reaching a truly calm state of mind is not easy, but with theanine, it may be a bit more reachable. This amino acid has consistently shown an ability to help calm us down, and when we’re talking about improving our mood, that effect is absolutely warranted!

  • Indole-3-Carbinol – 200mg

    Drawing upon the nutrient powerhouses that are cruciferous vegetables, Indole-3-Carbinol (I3C) is a phytochemical derived from compounds called glucosinolates within these veggies.[22] Modern medicine is currently looking into adapting I3C for potential cancer treatment, but in the case of this product, we’ll be talking about its potential anti-estrogen characteristics.

    I3C / DIM Estrogen Metabolites

    I3C works similarly to DIM (Diindolylmethane), whose estrogen metabolites are shown here. Image courtesy HLHT

    Earlier, we mentioned that high cortisol levels tend to yield low testosterone production. Because testosterone and estrogen work almost as a see-saw of sorts, high estrogen levels are correlated with high cortisol levels. When talking about hormonal balance, it’s undesirable to have too much (or too little) of either hormone. That’s where I3C comes in.

    Research has shown I3C to be effective in maintaining optimal estrogen levels, whether by means of increasing or decreasing the hormone.[23] I3C may also be able to downregulate the conversion of testosterone to estrogen, a process that typically takes place when the body is not using testosterone efficiently.[24] Granted, existing research seems to be focused specifically on breast cancer cells, which is a niche application. That being said, the pathways in which I3C operate through are directly used to make estrogen,[23] so there’s definitely some validity here.

    Why not DIM?

    PEScience TruNeuro

    As you age, your brain ages even more. TruNeuro was designed to prevent the decline with three amazingly-dosed ingredients that can be taken “forever”.

    3,3-diindolylmethane, thankfully abbreviated with DIM, is another popular “estrogen-balancing” ingredient. It’s actually a metabolite of I3C,[25] meaning it actually comes from I3C! As it turns out, I3C and DIM work in an almost identical fashion – they both inhibit aromatase production, which helps downgrade estrogen production.[23] Both reduce production of estradiol, commonly referred to as “bad” estrogen.[23] That’s great, but why did PEScience decide to go with one of these over the other?

    Simply put, I3C is handled better in digestion. You see, DIM isn’t exactly something you typically consume alone. Rather, you eat cruciferous vegetables like broccoli, which yields I3C (among other nutrients), which is then broken down into DIM. According to PEScience, this metabolized version of DIM is therefore much more bioavailable than a supplemented form, being a naturally-occuring form of the compound.

    Because everything else on this label influences your hormones, especially cortisol, in some way, tossing in a little additional hormonal-balancing help makes a ton of sense. Sure, Omnizen is going to decrease stress levels and hopefully help you relax, but what happens to your body when you first experience stress or anxiety? Your hormones take a beating! Teaming I3C up with the other ingredients here gives you a fully-loaded attack on hormonal imbalance, which will only help you maintain optimal levels in the future!

Dosage

The above ingredient analysis is based upon a full 3-capsule serving of Omnizen. You can start lower and take 1-3 capsules, preferably with a meal, when you think it’ll be best served.

PEScience Omnizen Dosage

Three capsules is the full clinical serving, but you can space them throughout the day with meals.

This could double as a sleep aid / relaxant before bed, so consider saving one of your capsules for pre-bed use to get a better start on the day!

Doing it without CBD

PEScience makes a note that this is a supplement meant to target the CBD-chasing crowd, but with more research involved – and more legal compliance too. This is something to consider for those interested in CBD but not yet convinced it’s all it’s cracked up to be – or for cautious retailers who still won’t carry it.

Conclusion – finally reach your zen!

It’s simply way too easy to get stressed out these days. Some of us are working long hours, others may be raising kids, and some people are trying to earn a degree. Whether you’re a parent, student, or just a plain ol’ adult, you must make sure you’re doing things to keep a healthy headspace.

Meditation works, but some people have trouble finding adequate time or space to correctly practice it. Other things, like mindfulness and positive reinforcement are great too, and we highly recommend that you give them a shot. But, sometimes a little extra push into a stress-free, calming environment can work wonders.

In Omnizen, PEScience isn’t pulling any punches – when they say they’re delivering a comprehensive mood-booster, they mean it! This formula attacks the things that can mess up a peaceful well-being from multiple different angles. Ensuring your cortisol is in check, optimizing overall hormonal levels, and inducing a bit of calmness are just a few things this stuff can do for you. But, most importantly, PEScience is giving you this label so that you can finally reach your zen!

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About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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References

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  11. Ahmad, M K, et al; “Withania Somnifera Improves Semen Quality by Regulating Reproductive Hormone Levels and Oxidative Stress in Seminal Plasma of Infertile Males.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Aug. 2010; https://www.ncbi.nlm.nih.gov/pubmed/19501822
  12. Mahdi, Abbas Ali et al; “Withania somnifera Improves Semen Quality in Stress-Related Male Fertility”; Evidence-based complementary and alternative medicine: eCAM, vol. 2011; 576962; 18 Jun. 2011; ttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136684/
  13. Wankhede, Sachin et al; “Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial”; Journal of the International Society of Sports Nutrition; vol. 12 43; 25 Nov. 2015; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658772/
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  15. White, Peter T, et al; “Natural Withanolides in the Treatment of Chronic Diseases.”; Advances in Experimental Medicine and Biology; U.S. National Library of Medicine; 2016; https://www.ncbi.nlm.nih.gov/pubmed/27671823
  16. “How to Pick Your Ashwagandha Supplier – KSM-66.”; KSM; http://ksm66ashwagandhaa.com/ashwagandha/how-to-pick-your-ashwagandha-supplier/
  17. Yamada, Takashi, et al; “Theanine, r-Glutamylethylamide, Increases Neurotransmission Concentrations and Neurotrophin MRNA Levels in the Brain during Lactation.”; Life Sciences; U.S. National Library of Medicine; 29 Sept. 2007; https://www.ncbi.nlm.nih.gov/pubmed/17904164
  18. Lu, Kristy, et al; “The Acute Effects Of L-Theanine in Comparison with Alprazolam on Anticipatory Anxiety in Humans.”; Human Psychopharmacology: Clinical and Experimental; vol. 19; no. 7; 2004; pp. 457–465; https://espace.library.uq.edu.au/view/UQ:284103
  19. Ritsner, Michael S, et al; “L-Theanine Relieves Positive, Activation, and Anxiety Symptoms in Patients with Schizophrenia and Schizoaffective Disorder: an 8-Week, Randomized, Double-Blind, Placebo-Controlled, 2-Center Study.”; The Journal of Clinical Psychiatry; U.S. National Library of Medicine; Jan. 2011; https://www.ncbi.nlm.nih.gov/pubmed/21208586
  20. “Effects of l-Theanine on Attention and Reaction Time Response.”; Journal of Functional Foods; Elsevier; 19 Apr. 2011; https://www.sciencedirect.com/science/article/pii/S1756464611000351
  21. Lyon, Michael R, et al; “The Effects of L-Theanine (Suntheanine®) on Objective Sleep Quality in Boys with Attention Deficit Hyperactivity Disorder (ADHD): a Randomized, Double-Blind, Placebo-Controlled Clinical Trial.”; Alternative Medicine Review : a Journal of Clinical Therapeutic; U.S. National Library of Medicine; Dec. 2011; https://www.ncbi.nlm.nih.gov/pubmed/22214254
  22. McNaughton, S A, and G C Marks; “Development of a Food Composition Database for the Estimation of Dietary Intakes of Glucosinolates, the Biologically Active Constituents of Cruciferous Vegetables.”; The British Journal of Nutrition; U.S. National Library of Medicine; Sept. 2003; https://www.ncbi.nlm.nih.gov/pubmed/13129476
  23. Marconett, Crystal N et al; “Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.”; Molecular biology of the cell; vol. 21,7; 2010; 1166-77; https://www.ncbi.nlm.nih.gov/pubmed/20130088
  24. Licznerska, Barbara E et al; “Modulation of CYP19 expression by cabbage juices and their active components: indole-3-carbinol and 3,3′-diindolylmethane in human breast epithelial cell lines.”; European journal of nutrition; vol. 52,5; 2013; 1483-92; https://www.ncbi.nlm.nih.gov/pubmed/23090135
  25. Aggarwal, Bharat B, and Haruyo Ichikawa; “Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives.”; Cell Cycle (Georgetown, Tex.); U.S. National Library of Medicine; Sept. 2005; https://www.ncbi.nlm.nih.gov/pubmed/16082211

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