Nutrex Lipo-6 Hardcore: Maximize Fat Burn, Preserve Muscle Mass

Nutrex Research The Warrior Series

Warrior Pre Workout is one of nine products in the complete Warrior Series line-up.

Nutrex Research kicked off May in a massive way, with the launch of the Warrior Series.

This new line features a mix of their best selling supplements, including Vitadapt Complete, EAA+ Hydration, Outlift Amped, and Alpha Pump, along with some never before seen products. In the last blog post, we covered Warrior Pre Workout, the flagship product of the Warrior Series and it definitely delivers intense energy, skin-splitting pumps, enhanced power, and locked-in focus — all at an incredible price point!

After seeing what Warrior Pre Workout had to offer, we could tell that Nutrex wasn’t messing around with this line. They specifically formulated the series for the more “serious” consumer, who’s willing to do whatever it takes to reach their goals. If you’re one of those people, then the Warrior Series is for you, the only question is… are you ready to take things to the next level? Because this next supplement is:

Lipo-6 Hardcore: Maximum Fat Burn, Maximum Results

Warrior Pre Workout may be the flagship product of the Warrior Series, but if there’s one thing that Nutrex is most well-known for, it’s their robust line of fat burners! Nutrex started the Lipo-6 line way back in 2002, it quickly took off and still dominates the industry today. Since then, Nutrex has vastly expanded the Lipo-6 series with new products, ingredients, and advanced formulas.

Nutrex Lipo-6 Hardcore

Experience a new level of fat burning with Lipo-6 Hardcore from Nutrex Research!

With how popular the Lipo-6 name is in the industry, the Warrior Series wouldn’t be complete without it! Fortunately, Nutrex Research has released an all new fat burner, with what may be the most comprehensive formula yet. To go along with their mission to cater to the most serious consumers, they rightfully named it Lipo-6 Hardcore. And if that name doesn’t speak for itself, just wait until you see the supplement fact panel!

Get ready to feel the heat with a combination of NNB Nutrition’s CaloriBurn-GP (grains of paradise), Alpha-Yohimbine, and caffeine anhydrous! If you’re serious about burning fat, and retaining as much lean muscle mass as possible, then Lipo-6 Hardcore is here to help you with that goal.

We have a full formula analysis for Lipo-6 Hardcore down below, but before we get into all the nitty gritty details, sign up for Nutrex Research news and deal alerts to get notified when new products, sales, and reviews go live!

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Lipo-6 Hardcore Formula Breakdown

Nutrex Lipo-6 Hardcore Ingredients

A few simple ingredients, backed by research and formulated for results.

Nutrex formulated Lipo-6 Hardcore to maximize the amount of fat you’re able to burn through three main mechanisms:

  • Increased thermogenesis and metabolism
  • Enhanced appetite control to reduce the desire to overeat
  • Improved energy for hours, keeping you more active throughout the day

Nutrex knows that diet and exercise are key components to losing fat and building muscle, but when that’s not enough, it’s time to reach for Lipo-6 Hardcore!

Lipo-6 Hardcore negate many of the negative effects of dieting, allowing you to stay on track.

Take the Lipo-6 Challenge

If you want to see just how powerful Lipo-6 Hardcore is, Nutrex challenges you to pick up a bottle, take one pill 2x per day (morning and afternoon) for a month. Along with a proper nutrition protocol and consistent exercise regimen, adding Lipo-6 Hardcore will help transform your body.

Here’s what one serving (one capsule) of Lipo-6 Hardcore provides:

Lipo-6 HARDCORE MAXIMUM FAT BURNER – 646.5mg

  • L-Tyrosine

    When you’re on a mission to lose fat, being in a caloric deficit for an extended period of time can not only take a toll on your physical energy, but your mental energy as well. You may start feeling unmotivated, get brain fog, and have a hard time focusing. Those are some of the reasons why Nutrex added in L-Tyrosine to kick off the Lipo-6 Hardcore formula.

    L-Tyrosine is a non-essential amino acid that’s found in several pre workouts, fat burners, nootropics, and even sleep-aids! L-Tyrosine supplementation in sports performance is used to boost the production of three key neurotransmitters including epinephrine, norepinephrine, and dopamine.[1,2] The research reports that L-Tyrosine is the superior form to take since it has enhanced bioavailability and absorption,[1] leading to greater increases in endogenous tyrosine levels.

    Nutrex Lipo-6 Gel Graphic

    Nutrex just keeps expanding the Lipo-6 line!

    Although tyrosine has various functions within the body, it’s primarily known for being a precursor for the synthesis of catecholamine neurotransmitters. Therefore, it’s been shown to boost athletic and mental performance via enhancing focus, mood, cognition, while also reducing stress.[2]

    Neurotransmitters are crucial for proper communication between neurons, cells, and both the central and peripheral nervous systems. Exercise and dieting will likely lead to the depletion of neurotransmitters, which would significantly reduce your ability to focus.

    Furthermore, epinephrine and norepinephrine, are two primary neurotransmitters involved in your sympathetic nervous system, also known as “fight or flight”. They help get the body prepared for movement by increasing heart rate, blood flow, blood glucose, slowing down digestion, and enhancing lipolysis. Therefore, they may help further increase fat burn in addition to focus. Whereas dopamine is crucial for motivation, reward, attention, and memory.

    You’re getting multiple benefits from L-Tyrosine and it’s one of the best forms available!

  • Caffeine Anhydrous

    A comprehensive fat burner wouldn’t be complete without some form of caffeine to get you going and you’re metabolism firing! Although it does not say the exact caffeine content on the label, Nutrex informed us that each serving (one capsule) has 300mg of caffeine. This is on of the reasons why one pill should be plenty!

    Nutrex Outlift Italian Ice

    Looking for a comprehensive pre workout? Outlift is the answer!

    Caffeine anhydrous is a synthetic form of caffeine, meaning it’s absorbed extremely quickly and raises your energy levels in no time. It’s well-known that caffeine is a powerful stimulant for boosting alertness, physical performance, and mental focus.[3-5] A good dose of caffeine will give you the energy to power through a cardio session, however there’s a lot more it can do to help aid fat loss!

    In addition to increasing your energy and caloric expenditure, caffeine also helps suppress appetite, increases metabolism, and enhances fat oxidation,[6,7] which is great for fat loss! Studies show that caffeine serves as a thermogenic by inhibiting the breakdown of cyclic adenosine monophosphate (cAMP).[6,7] Caffeine achieves this effect by acting as an phosphodiesterase antagonist, which is an enzyme responsible for the metabolism of cAMP.

    cAMP is a secondary messenger in various physiological processes and pathways. You could consider it to be the “middle man” that helps relay signals and messages between cells. It’s most notably involved in glucose and lipid metabolism, therefore without adequate levels of cAMP, then your ability to burn fat for fuel is greatly decreased. But with caffeine supplementation, you can prevent the breakdown of cAMP, and turn yourself into a fat burning machine!

    Caffeine may be a powerful tool for fat loss, but this next ingredient will really bring the heat!

  • CaloriBurn GP (Grains of Paradise) (seed)

    CaloriBurn GP comes from a leader in ingredient research and development, NNB Nutrition.

    CaloriBurn

    No more untrustworthy grains of paradise extracts needed – we now have CaloriBurn by NNB Nutrition!

    Ever since this trademarked form of grains of paradise (GP) was introduced to the supplement industry, it caught fire. The beneficial effects of GP have been well documented in the literature, however, getting a high quality extract is crucial to see results. Fortunately, NNB Nutrition developed CaloriBurn GP to give you the piece of mind that it’s 100% pure and unadulterated.[8,9]

    Furthermore, NNB Nutrition used a specific extraction method for CaloriBurn GP to preserve as many bioactive ingredients as possible to yield even greater metabolic effects.[8,9] This is one of the reasons why PricePlow is such a huge advocate for CaloriBurn GP over other forms, because we believe it’s the most potent grains of paradise derivations available!

    Now that you know CaloriBurn is a tested and trusted ingredient, let’s see what it has to offer for fat loss!

    Grains of Paradise (GP), also known as Aframomum melegueta, is a spice that’s closely related to ginger and native to West Africa.[8,9] GP is commonly used to add a spicy flavor to foods, but with a high enough dose, it can have some profound fat burning effects!

    GP contains multiple bioactive constituents that are attributed to it’s thermogenic effects. The primary components noted in the literature are 6-gingerol, 6-paradol, 6-shogaol, and 6-gingeredione. CaloriBurn contains 12.5% 6-paradol as it’s main constituent, but it also contains the others as well.[8,9]

    NNB Nutrition CaloriBurn

    CaloriBurn is a potent extract of Grains of Paradise, which has multiple fat burning positive effects!

    NNB specifically standardized the 6-paradol content, because it seems to be the most responsible for increased thermogenesis.[10,11]

    Research has shown that GP is able to help convert white adipose tissue (WAT), which is your fat storage, to more metabolically active, brown adipose tissue (BAT).[10,11] And having more BAT opposed to WAT is better for overall body composition since it burns more calories and stores less adipocytes (fat cells). Furthermore, greater levels of BAT boosts glucose metabolism and positively affects lipid profiles.[11]

    GP is a phenomenal ingredient to help you burn more fat, but also keep it off forever!

    If you want to read more about CaloriBurn, check out this blog article: CaloriBurn: NNB Takes Grains of Paradise to Hot New Heights!

  • BioPerine [(Piper nigrum extract) (fruit)]

    Piper nigrum extract, also known as black pepper fruit, is an ingredient that can help the other ingredients carry out their effects by increasing bioavailability and absorption.[12] It’s well established that certain dietary supplements don’t get absorbed by very well, leaving them unable to express their full potential.

    Bioperine

    Bioperine is the trusted, trademarked form of black pepper extract that promises 95% or greater piperine, the part of black pepper with all the activity!

    Through oral supplementation, the digestive system will breakdown the compounds and instead of getting into circulation through the small intestine, they just pass on by. As a result, you excrete the ingredients rather than using them.

    Fortunately, innovative ingredient suppliers have developed a solution to this problem with BioPerine. This is a black pepper extract standardized to contain a minimum 95% piperine (the primary bioactive constituent).[12] Research shows that BioPerine has three main mechanisms of action:

    • Modulates Efflux Mechanism
    • Modulates Metabolizing Enzymes
    • Increases Thermogenesis

    What’s unique about BioPerine is that not only does it help the other ingredients work more efficiently, it can induce thermogenesis on its own.[13] Studies show that piperine is able to activate the release of hormones responsible for thermogenesis, such as catecholamines, without the need of cAMP.[13]

    Needless to say, BioPerine is quite a powerful addition to a fat burner and we’re glad to see it in the formula!

  • Rauwolfia (Rauwolfia vomitoria) extract (root)

    This ingredient seems to be a common addition to the Warrior Series, because you can also find it in Warrior Pre Workout!

    Nutrex Research Warrior Sour Drop

    Warrior has to be one of Nutrex’s strongest pre workouts to date!

    Alpha-Yohimbine, the common name for Rauwolfia, is a potent sympathetic nervous system stimulant. It’s more of an advanced ingredient, and you only really see it in high stim pre workouts or strong fat burners. Therefore, it makes sense that “alpha-yo” is included in both Warrior Pre Workout and Lipo-6 Hardcore beacuse the more “advanced” lifter is who the series is designed for.

    You may have heard of yohimbine, however Alpha-yohimbine is not exactly the same thing. Although they both have very similar names, structures, and benefits, alpha-yohimbine doesn’t result in the negative effects associated with regular yohimbine, such as jitters, cold sweats, nervousness, and anxiety. It does not happen to everyone, but those are some of the commonly reported side effects of yohimbine supplementation.

    So what does Alpha-yohimbine do for fat loss? Well, studies have shown significant increases in energy, fat oxidation, libido, mood, and reduced appetite.[14-17] Alpha yohimbine expresses its effects by inhibiting the alpha-2 receptors, which results in enhanced lipolysis and reduced fat storage.[14,15] And you know what that means… greater fat burning!

  • Toothed Clubmoss (Huperzia serrata) extract (aerial)

    The last ingredient included in Lipo-6 Hardcore is none other than Toothed Clubmoss, also known as Huperzia serrata.

    Nutrex Research Male Athletes Gym

    Intense training requires intense focus.

    Huperzine A is an alkaloid derived from the Huperzia serrata plant that’s been used for years in Traditional Chinese Medicine. Huperzine A is starting to make its way into several sports supplements including nootropics, pre workouts, fat burners, and even some sleep-aids.

    It’s known for having potent anti-inflammatory properties due to its ability to inhibit an enzyme called acetylcholinesterase.[18-20]

    Acetylcholine is a major neurotransmitter within the body and it significantly enhances nerve transmission and cell signaling.[18-20] Greater levels of acetylcholine are not only great for brain health, but physical performance as well. They can enhance focus, memory, mental energy, and mind-to-muscle connection.[18-20]

    If you want to be locked in for your training sessions, then this is one ingredient that will help with that!

Check out this video to learn more about Lipo-6 Hardcore!

Subscribe to PricePlow on YouTube!

Nutrex Keeps The Lipo-6 Series Running Strong

Nutrex Research has definitely earned the title of a “Legacy Brand”, they’ve been running strong since 2002 and continue to improve each year. The Warrior Series was a massive project for them to undertake, but it was well worth it. The new look is eye-catching, the products are well-formulated, and they’re now able to reach a new audience.

Nutrex Lipo-6 Black Graphic

One of the best sellers in the Lipo-6 series!

Lipo-6 has developed into a household name in the fat burner category, and Nurtex is continuing to keep the series going with the addition of Lipo-6 Hardcore. Keep in mind, this is one of their more advanced fat loss formulas, therefore depending on your level of experience, there may be other options that suit your needs better.

Lipo-6 Hardcore was formulated for the more elite lifter or fintess enthusiast who’s already tried other fat burners on the market, but wants something that will continue to deliver results. If that sounds like you, then definitely give Lipo-6 Hardcore a shot! But if not, Nutrex has plenty of other options to choose from!

This is really just the start of the Warrior Series, and Nutrex has a lot more planned coming up. You’re not going to want to miss what they have in store, so subscribe down below and we’ll let you know when new products, flavors, deals, and reviews are released!

Note: You can see all Lipo-6 products by searching PricePlow for Lipo-6.

Nutrex Lipo-6 Hardcore - Deals and Price Drop Alerts

Get Price Alerts

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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

About the Author: Heather Jacques

Heather Jacques

Heather Jacques, AT, ATC, has a Bachelors of Science in Exercise Science with an emphasis in Athletic Training. She is a researcher, athletic trainer, and fitness enthusiast who is PricePlow’s Digital Content Manager. Heather constantly stays up to date with the latest scientific literature in order to provide the best information for the readers.

Heather’s goal is to educate, empower, and give people the tools to reach their fitness and health related goals. There are far too many myths out there and Heather is here to provide the truth.

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References

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  2. Attipoe, S. et al; Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature; Military Medicine; Volume 180, Issue 7, July 2015, Pages 754–765; https://academic.oup.com/milmed/article/180/7/754/4160625#101253256
  3. Trexler ET, Smith-Ryan AE, Roelofs EJ, Hirsch KR, Mock MG. Effects of coffee and caffeine anhydrous on strength and sprint performance. Eur J Sport Sci. 2016;16(6):702–710; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803635/
  4. Davis JK and Green JM; “Caffeine and anaerobic performance: ergogenic value and mechanisms of action;” Sports Med. 2009;39(10):813-32; https://pubmed.ncbi.nlm.nih.gov/19757860
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  8. NNB Nutrition; CaloriBurn GP Ingredient Overview; 2020; https://nnbnutrition.com/products/caloriburn/
  9. Roberto, Mike; CaloriBurn: NNB Takes Grains of Paradise to Hot New Heights; PricePlow Blog; April, 4th 2020; https://blog.priceplow.com/supplement-ingredients/caloriburn
  10. Kim SH, Plutzky J; “Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders”; Diabetes & Metabolism Journal. 2016;40(1):12-21; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768046/
  11. Sugita, J., Yoneshiro, T., et al; “Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men”; British Journal of Nutrition; (2013) 110(4), pp. 733–738; https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/grains-of-paradise-aframomum-melegueta-extract-activates-brown-adipose-tissue-and-increases-whole-body-energy-expenditure-in-men/517F8F0D73864C919E42D502537BA01D/core-reader
  12. Sabinsa Corp; BioPerine Research Information; 2020; https://www.bioperine.com/index.php/researchhighlight
  13. Sabinsa Corp; BioPerine Mechanisms of Action; 2020; https://www.bioperine.com/index.php/mechanismsofactions
  14. Perry BD, U’Prichard DC. “(3H)rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors”; Eur J Pharmacol.; 1981; https://pubmed.ncbi.nlm.nih.gov/6276200
  15. Garenc C, Pérusse L, Chagnon YC, et al. “The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study;” Molecular Medicine. 2002;8(2):88-94. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2039973/
  16. Arthur JM, Casañas SJ, Raymond JR. “Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT1A receptors”; Biochem Pharmacol.; 1993; https://pubmed.ncbi.nlm.nih.gov/8517875
  17. Wainscott DB, et al; “[3HRauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor”; Naunyn-Schmiedeberg’s Archives of Pharmacology 357 (1): 17–24; 1998; https://pubmed.ncbi.nlm.nih.gov/9459568
  18. Zhao, Q, and X C Tang; “Effects of Huperzine A on Acetylcholinesterase Isoforms in Vitro: Comparison with Tacrine, Donepezil, Rivastigmine and Physostigmine.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; 29 Nov. 2002; https://pubmed.ncbi.nlm.nih.gov/12445575
  19. Xu, Z Q, et al; “Treatment with Huperzine A Improves Cognition in Vascular Dementia Patients.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Jan. 2012; https://pubmed.ncbi.nlm.nih.gov/21833673
  20. Zhang, H Y, and X C Tang; “Neuroprotective Effects of Huperzine A: New Therapeutic Targets for Neurodegenerative Disease.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Dec. 2006; https://pubmed.ncbi.nlm.nih.gov/17056129

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