Merica Labz Drops an F-BOMB (Extreme Stim Pre-Workout)
We love the guys at ‘Merica Labz for doing everything American style – that means going big and pushing the boundaries of convention in the best tradition of American ingenuity.
To celebrate Black Friday 2022, they’ve really outdone themselves with an updated version of F-BOMB, an absolute monster of a stimulant-based workout whose effects will be felt by even the most level-headed among us. While we love their other pre-workouts like the original Red, White, & BOOM and the fat-burning hybrid NAPALM Red, White, & Boom, F-Bomb is for those looking for a little…actually a lot… more.
Do it for America
F-BOMB is going to put you over the top on that final rep, that last mile, or those last few dozen bleacher reps – and you won’t just be doing it for yourself, you’ll also be doing it for America.
Inside, we’ve got 473 milligrams of total caffeine paired with a whole slew of stimulants, including synephrine, theobromine, and coffee fruit extract. On the pump side, we have Nitrosigine and FitNox put together, a combination that’s becoming popular. This is no joke and most will want to do a half-scoop.
Below, we detail the formula per the late 2022 release, which was out in four new flavors. The new flavors will be highlighted in yellow below:
Merica Labz F-Bomb – Deals and Price Drop Alerts
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Merica Labz F-Bomb Ingredients (August 2022 Edition)
In a single 1 scoop (15.1 gram) serving of F-BOMB from ‘Merica Labz, you get the following:
Beta-Alanine – 6,400 mg
First we have beta-alanine, an endurance-boosting ingredient whose efficacy is so great that it’s been a standard pre-workout ingredient for over a decade.
Beta-alanine is an amino acid that combines with L-histidine, another amino acid, to produce carnosine, which your body uses to remove lactic acid from muscle tissue. Since the buildup of lactic acid in muscle tissue causes muscles to feel fatigue during exercise, removing it more efficiently means your muscles can work harder for longer.
Studies on beta-alanine supplementation have repeatedly shown it can improve overall athletic performance by increasing time to exhaustion[2,3] and power output, while improving body composition in the long-run.
The specific dose used in F-BOMB, 6.4 grams per day, is twice the dose that’s been validated as efficaciousby two different meta-analyses, which both concluded that a mere 3,200 mg benefits the performance of any exercise between 30 seconds and 10 minutes in duration.
Nitrosigine (as inositol-stabilized arginine silicate) – 1,500 mg
Nitrosigine is a chemical complex of the amino acid arginine, the carbohydrate inositol, and potassium silicate, sometimes referred to by the abbreviation ASI. The point of Nitrosigine is to increase the bioavailability of arginine, an amino acid that falls under the category of “semi-essential” or “conditionally essential,” meaning that although your body can synthesize some arginine endogenously, it can’t necessarily make enough to cover all of your metabolic requirements, particularly when you’re sick or stressed.
Arginine is important to human biochemistry because of its role in nitric oxide (NO) production. Arginine is an NO precursor, the discovery of which led to decades of attempts to raise NO blood levels through arginine supplementation. Although marginally effective, this approach was eventually deemed inefficient due to arginine’s low oral bioavailability.
Nitrosigine increases arginine bioavailability by using inositol and potassium silicate to buffer it against the enzyme arginase, which ordinarily degrades arginine in your stomach before it can be absorbed by your intestines.
Nitrosigine does a great job as a delivery vehicle for arginine: supplemental Nitrosigine has been shown to significantly increase NO production just 30 minutes after ingestion, for a period of up to six hours.[9,10]
Elevated levels of NO in your blood mean increased vasodilation, a mechanism that expands your arteries’ diameter to permit a greater throughput of blood.
Better circulation means that oxygen and nutrients get delivered to your cells more efficiently – and waste products get removed more efficiently as well.
Both of these effects can not only increase athletic performance, but also speed up recovery following exercise.
The added nootropic effects of nitric oxide from Nitrosigine
However, arteries deliver blood to your entire body, so unsurprisingly, increased NO doesn’t only have physical benefits – mental and cognitive benefits attend higher NO levels as well!
For example, Nitrosigine supplementation has been shown to prevent the temporary cognitive impairment that is typically caused by intense exercise.
But even in non-exercisers, Nitrosigine has been shown to improve task switching, a measure of cognitive flexibility and multitasking. Newer research published at the end of 2021 also demonstrated improvements to short-term memory as well.
L-Tyrosine – 1,000 mg
Tyrosine usually makes an appearance in pre-workout formulas because it’s an important precursor to catecholamine neurotransmitters like dopamine and adrenaline, which most readers are probably familiar with already. By increasing your levels of these neurotransmitters, tyrosine supplementation can trigger energy mobilization, the release of energy substrates like glucose and fatty acids into your bloodstream, enabling your cells to take them up and burn them for energy.
Because adrenaline helps trigger the fight or flight response to acute stress, and dopamine is involved with mood, focus, and motivation, increasing catecholamine production can definitely help you get through a tough workout, and perform your best.
Tyrosine synergizes well with another ingredient in the F-BOMB formula, namely caffeine: while tyrosine increases catecholamine production, caffeine actually triggers the release of catecholamines into your bloodstream, where they circulate throughout your body. The upshot of this one-two punch is significantly elevated mood and increased energy utilization (metabolic rate).
Tyrosine also affects your body’s metabolism more directly by supporting thyroid hormone production and increasing thyroid function.[18-20] As an important precursor to the synthesis of triiodothyronine (T3) thyroxine (T4), tyrosine can help combat the anti-thyroid effects of intense exercise and calorie restriction,[21,22] something that most serious athletes and gym goers have practiced on a semi-regular basis.
Tyrosine can also help manage stress, especially in sleep-deprived people. In fact, tyrosine might even be better at helping people cope with fatigue than caffeine,[24,25] which is saying a lot!
Caffeine Anhydrous – 400 mg (of 473 mg total caffeine)
Caffeine is another pre-workout classic, and for equally good reason.
As most of us probably know, caffeine helps fight fatigue. It does this by inhibiting the action of adenosine, a metabolic byproduct that builds up in our brain during waking hours and produces feelings of tiredness as it accumulates.[26,27]
Caffeine’s anti-adenosine effect, which is mediated by caffeine’s ability to block adenosine receptors, is the main reason why tired people the world over reach for that extra mug of tea or coffee…
But caffeine affects your body’s energy levels in other important ways too. It also inhibits phosphodiesterase, the enzyme that breaks down cyclic adenosine monophosphate (cAMP).[26,27]
Because cAMP regulates the rate at which your body burns carbs and fat for energy, higher cAMP levels mean more energy availability at the cellular level. Raising cAMP levels through phosphodiesterase inhibition is the main reason why caffeine has ergogenic properties – it increases not just mental but also physical and athletic performance.
In other words, increased cAMP means a higher metabolic rate, and in caffeine’s case, a higher rate of fat burning specifically. According to one study, caffeine may increase your body’s rate of fat burning by an incredible 50%.
This can not only fuel your workout, but also help you achieve your body composition goals faster by increasing the number of calories you burn every day!
Caffeine is incredibly well studied, with dozens if not hundreds of excellent peer-reviewed studies showing that caffeine consumption can increase strength, endurance, and power.
The use of caffeine also can have significant nootropic effects – beyond merely fighting feelings of fatigue, it has been shown to produce faster reaction times, improved attention,[31,32] and higher alertness.
Caffeine might also increase working memory, the main determinant of fluid intelligence that is known to decrease as we age.
Hard to say enough good things about caffeine – if you can tolerate it. Not everybody can, and over 400 milligrams is a pretty big dose to take all at once, so if you aren’t sure whether you can handle it, start with smaller amounts of caffeine and taper up to the full dose.
That’s strong, but now here’s where things get really fun:
Alpha GPC 50% (L-Alpha-Glycerylphosphorylcholine) – 300 mg
This highly bioavailable form of choline is capable of crossing the blood-brain barrier, which enables it to effectively function as a precursor to acetylcholine, a neurotransmitter that we often call the “learning neurotransmitter” because of how crucial it is for learning, memory, attention, and alertness.[35,36] Choline is critical for brain development, and is a de-facto nootropic ingredient.
But acetylcholine’s ability to promote interneuronal communication ends up affecting more than just mental processes: balance and coordination appear to be improved by acetylcholine as well.
Although Alpha GPC is a form of choline that’s specialized for brain effects, it’s also worth mentioning that choline is important for fat burning[40-43] and helps your body retain dietary carnitine. Carnitine helps your body burn fat for energy.[44-46]
Not getting enough choline is pretty bad – it can cause non-alcoholic fatty liver disease (NAFLD), cognitive dysfunction, and general organ damage.[47-49]
FitNox® (as Moringa oleifera Leaf Extract, Punica granatum Extract & Kaempferia parviflora Extract) – 250mg
FitNox is a plant-based NO booster designed by Glanbia Nutritionals. It consists of three different botanical extracts that were selected for their synergistic effect on NO production.
One 2018 study found that a 250 mg dose of FitNox is able to upregulate salival and serum nitrate and nitrite levels by over 300% after just one dose. In that study, the effect lasted for 10 hours or more!
In another study, subjects who took 250 mg of FitNox for 22 days not only had higher NO levels, but also had longer time to exhaustion and lower levels of compounds that induce muscular fatigue. In this study subjects were also found to have higher dopamine levels, which is a boon for motivation and focus, and can definitely help you adhere to a challenging nutrition and fitness regimen.
The mechanism of action behind FitNox is upregulation of nitric oxide synthase, the enzyme that your body uses to produce NO.
Dicaffeine Malate – 100 mg (yields 73 of 473 mg total caffeine)
Dicaffeine malate has the usual effects of caffeine,[52-55] but a different energy curve: it acts slower and over a longer period of time than caffeine anhydrous.
This naturally leads to a gentler buzz without nearly as much of an energy crash as the caffeine inevitably wears off.
The reason this happens is the malic acid molecule bound to the caffeine acts as a kind of digestive buffer, basically slowing down your body’s absorption of the caffeine molecule.
Stacking dicaffeine malate with caffeine anhydrous can help give you the best of both worlds: fast-acting anhydrous for an immediate boost, plus the malate form to help manage withdrawals.
Note that this brings our caffeine total up to 473 milligrams – a not small dose – since dicaffeine malate is about 73% caffeine by weight.
CognatiQ (Whole Coffee Fruit Extract) (Coffea Arabica) – 100 mg
Formerly known as NeuroFactor, CognatiQ is a coffee fruit developed with focus and cognition in mind. It works by increasing brain-derived neurotrophic (BDNF) expression. BDNF is a protein that supports the maintenance, growth, and overall survival of neurons in the brain.[57,58] It helps regulate neuroplasticity (the ability for the brain to respond and reshape when learning) in the hippocampus, the site of long-term potentiation (LTP).
Research has shown a strong correlation between cognitive performance and high BDNF levels in the blood.[57-62] In fact, higher levels of BDNF seem to help protect the brain from neurodegenerative diseases,[57,58,61,62] while low levels increase the risk for such illnesses.
When boosting BDNF, we often see improved cognitive performance, but have also seen a boost in aerobic exercise as well!
A research study showed that a 100-milligram dose of coffee fruit extract — what we have here in F-BOMB — can boost BDNF levels in the blood by nearly 150%!
We’ve also noticed, anecdotally, that supplements with NeuroFactor / CognatiQ simply feel better. Great to have it here.
Theobromine – 100mg
One of caffeine’s three major metabolites, theobromine is another methylxanthine, but with longer-lasting, milder effects than caffeine. This may help the energy from F-BOMB stick around longer… as if we needed more methylxanthine support!
Theobromine has research backing its use as an anti-inflammatory ingredient, appetite suppressant, and can provide cardioprotective effects.[63,64]
Like caffeine, theobromine inhibits adenosine and phosphodiesterase. It’s milder, but longer-lasting, with a greater half-life than caffeine.
We often like to cite a study that discovered that theobromine increases ratings of feel for users. And that’s what the ‘F’ in F-BOMB stands for…. right??
Synephrine HCl – 30 mg
Synephrine is a powerful beta agonist that targets the beta-3 adrenoceptor more than the beta-2 one, leading to some potent energetic and thermogenic effects.
Specifically, synephrine does a great job binding to the beta-3 adrenergic receptors in your body’s adipose (fat) tissue, which, again, activates the cyclic adenosine monophosphate (cAMP) cascade and increases your body’s ability to burn glucose and fat for energy.
Interestingly, the beta-3 adrenergic pathway seems to have much less of an effect on heart rate of blood pressure, compared to the beta-2 adrenergic pathway, meaning there’s less cardiovascular downside to using synephrine.
Synephrine also, unsurprisingly, increases basal metabolic rate and decreases appetite, making it another great ergogenic stimulant.
In one double-blind, placebo-controlled study from 2016, subjects who supplemented with synephrine burned significantly more fat during their workout than those who got a placebo.
A 2015 study found that combining synephrine and caffeine – which F-BOMB does – provided an even greater increase in fat oxidation than other ingredient alone.
Aside from the whopping dose of caffeine, this is really the ingredient that puts the ‘F’ in F-BOMB!
Huperzia serrata Extract (leaf and stem) (1% Huperzine A) – 10 mg
Huperzine A, like alpha-GPC, is here because of its effects on the acetylcholine system.
Whereas acetylcholine precursors like alpha-GPC increase acetylcholine production, huperzine A helps raise your acetylcholine levels by inhibiting the enzyme acetylcholinesterase, which is responsible for breaking down acetylcholine.
This basically means that your acetylcholine levels fall more slowly, and stay elevated longer thus amplifying the effects of the alpha-GPC in F-BOMB.
Huperzine A works well enough at keeping acetylcholine levels high that huperzine A on its own significantly improves cognition and learning.
Huperzine A also has antioxidant properties, and helps protect the mitochondria in your neurons from free radicals.
Leave it to ‘Merica to come up with some colorful flavor names, with even more colorful imagery near each one:
The ones in yellow above are the new flavors released on Black Friday 2022. Other flavors, if available, will be gone soon, so grab them while you can
Drop the F-Bomb: A Pre-Workout that Lives Up to Its Name
F-BOMB lives up to its name – this is a truly explosive formula absolutely jam-packed with stimulants and pump agents to give you a huge burst of energy for your hardest workouts. With these changes, we expect F-BOMB sales to literally pop off.
Stimmed up formulas work really well for some people – for other people, not so much. What gives one person a clean, sustainable buzz might give another the jitters and keep him up at night.
Ultimately, as with anything else, only you are responsible for assessing your tolerance. If you’ve never taken synephrine, for example, start with a partial scoop of F-BOMB and work your way up to a full scoop.
Of course, if you need to tone it down from Merica Labz, check out Red, White, and BOOM or NAPALM Red, White, and Boom. If you couldn’t tell, alongside Merica Energy, this kind of product line is the future of Merica Labz.
Merica Labz F-Bomb – Deals and Price Drop Alerts
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Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.
Posts are sponsored in part by the retailers and/or brands listed on this page.
- Trexler, E.T., Smith-Ryan, A.E., Stout, J.R. et al.; “International society of sports nutrition position stand: Beta-Alanine.”; J Int Soc Sports Nutr 12, 30 (2015); https://jissn.biomedcentral.com/articles/10.1186/s12970-015-0090-y
- Hobson, R M, et al; “Effects of β-Alanine Supplementation on Exercise Performance: a Meta-Analysis.”; Amino Acids; Springer Vienna; July 2012; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374095/
- Sale, Craig, et al; “Effect of β-Alanine plus Sodium Bicarbonate on High-Intensity Cycling Capacity.”; Medicine and Science in Sports and Exercise; U.S. National Library of Medicine; Oct. 2011; https://www.ncbi.nlm.nih.gov/pubmed/21407127
- Van, R, et al; “Beta-Alanine Improves Sprint Performance in Endurance Cycling.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Apr. 2009; https://www.ncbi.nlm.nih.gov/pubmed/19276843
- Vijaya Juturu V., Komorowski, JR. 2002. US7576132B2 – “Arginine Silicate Inositol Complex and use Thereof.” The United States Patent and Trademark Office. https://patents.google.com/patent/US7576132
- MedlinePlus. “Amino Acids: MedlinePlus Medical Encyclopedia.” Medlineplus.gov, 2017, http://www.medlineplus.gov/ency/article/002222.htm
- Komorowski, J., Perez, S., & Sylla, S; “Arginase Inhibition by Inositol-stabilized Arginine Silicate (ASI; Nitrosigine); A Novel Mechanism by which ASI Enhances Arginine Bioavailability”; Poster Presentation. Retrieved from https://www.eventscribe.com/2018/Nutrition2018/ajaxcalls/PosterInfo.asp?efp=UlhTRFpZVVI0ODYw&PosterID=146640&rnd=0.1401379
- Sandler, D., et al. June 2016. “Absorption of Bonded Arginine Silicate Compared to Individual Arginine and Silicon Components.” Journal of the International Society of Sports Nutrition vol. 13. https://jissn.biomedcentral.com/articles/10.1186/s12970-016-0144-9
- Rood-Ojalvo, S. et al. Sep. 2015. “The Benefits of Inositol-Stabilized Arginine Silicate as a Workout Ingredient.” Journal of the International Society of Sports Nutrition vol. 12(S1). https://jissn.biomedcentral.com/articles/10.1186/1550-2783-12-S1-P14
- Kalman, D. et al. June 2018. “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) On Cognitive Flexibility.” Nutrients https://blog.priceplow.com/wp-content/uploads/nitrosigine-cognitive-flexibility-issn-2018.pdf
- Helms CC, Gladwin MT and Kim-Shapiro DB (2018) Erythrocytes and Vascular Function: Oxygen and Nitric Oxide. Front. Physiol. 9:125. doi: 10.3389/fphys.2018.00125 https://www.frontiersin.org/articles/10.3389/fphys.2018.00125/full
- Stryer, Lubert (1995). Biochemistry, 4th Edition. W.H. Freeman and Company. p. 732
- Evans, M., Zakaria, N., & Marzuk, M; “An Evaluation of the Effects of Inositol-Stabilized Arginine Silicate (ASI; Nitrosigine) in Preventing the Decline of Cognitive Function Caused by Strenuous Exercise”; International Society of Sports Nutrition 2018 Conference; 2018; https://blog.priceplow.com/wp-content/uploads/nitrosigine-preventing-cognitive-decline-caused-by-strenuous-exercise.pdf
- Kalman, D., Hewlings, S., Sylla, S., Ojalvo, S., & Komorrowski, J; “An evaluation of the effects of inositol-stabilized arginine silicate (ASI; Nitrosigine) on cognitive flexibility”; Nutrients; 2016; https://blog.priceplow.com/wp-content/uploads/nitrosigine-cognitive-flexibility-issn-2018.pdf
- Gills, Joshua L et al. “Acute Inositol-Stabilized Arginine Silicate Improves Cognitive Outcomes in Healthy Adults.” Nutrients vol. 13,12 4272. 26 Nov. 2021, doi:10.3390/nu13124272; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8703995/
- Pietz J, Landwehr R, Kutscha A, Schmidt H, de Sonneville L, Trefz FK; “Effect of high-dose tyrosine supplementation on brain function in adults with phenylketonuria”; J Pediatr. 1995;127(6):936-943; https://www.ncbi.nlm.nih.gov/pubmed/8523192
- Belza, A., Toubro, S., & Astrup, A. (2007); “The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake”; European Journal of Clinical Nutrition, 63(1), 57-64; https://www.ncbi.nlm.nih.gov/pubmed/17882140
- Mullur, Rashmi et al. “Thyroid hormone regulation of metabolism.” Physiological reviews vol. 94,2 (2014): 355-82. doi:10.1152/physrev.00030.2013 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044302/
- Mullur, Rashmi et al. “Thyroid hormone regulation of metabolism.” Physiological reviews vol. 94,2 (2014): 355-82. doi:10.1152/physrev.00030.2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044302/
- Rousset, Bernard. “Chapter 2 Thyroid Hormone Synthesis And Secretion.” Endotext. U.S. National Library of Medicine, 2 Sept. 2015; https://www.ncbi.nlm.nih.gov/books/NBK285550/
- Rousset, Bernard, et al. “Chapter 2 Thyroid Hormone Synthesis and Secretion.” Nih.gov, MDText.com, Inc., 2 Sept. 2015. https://www.ncbi.nlm.nih.gov/books/NBK285550/
- Mullur, Rashmi, et al. “Thyroid Hormone Regulation of Metabolism.” Physiological Reviews, vol. 94, no. 2, Apr. 2014, pp. 355–382, 10.1152/physrev.00030.2013; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044302/
- Institute of Medicine (US) Committee on Military Nutrition Research (1994, January 01); “Tyrosine and Stress: Human and Animal Studies”; https://www.ncbi.nlm.nih.gov/books/NBK209061/
- Attipoe, Selasi, et al. “Tyrosine for Mitigating Stress and Enhancing Performance in Healthy Adult Humans, a Rapid Evidence Assessment of the Literature.” Military Medicine, vol. 180, no. 7, July 2015, pp. 754–765, 10.7205/milmed-d-14-00594; https://academic.oup.com/milmed/article/180/7/754/4160625
- Pomeroy, Diane E., et al. “A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel.” Nutrients, vol. 12, no. 2, 20 Feb. 2020, p. 545, 10.3390/nu12020545; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071459/
- Nehlig A, Daval JL, Debry G.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects”; Brain Res Rev. 1992;17(2):139-170. https://pubmed.ncbi.nlm.nih.gov/1356551/
- Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance.”; J Int Soc Sports Nutr 7, 5 (2010); https://jissn.biomedcentral.com/articles/10.1186/1550-2783-7-5
- Diepvens, K et al; “Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea;” American Journal of Physiology; 2007; https://journals.physiology.org/doi/full/10.1152/ajpregu.00832.2005
- Norager, C B, et al; “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.”; Clinical Endocrinology; U.S. National Library of Medicine; Aug. 2006; https://www.ncbi.nlm.nih.gov/pubmed/16886964
- Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008 Dec;33(6):1319-34. doi: 10.1139/H08-130; https://pubmed.ncbi.nlm.nih.gov/19088794/
- Kahathuduwa CN, Dassanayake TL, Amarakoon AMT, Weerasinghe VS. Acute effects of theanine, caffeine and theanine-caffeine combination on attention. Nutr Neurosci. 2017 Jul;20(6):369-377. doi: 10.1080/1028415X.2016.1144845; https://pubmed.ncbi.nlm.nih.gov/26869148/
- McLellan TM, Caldwell JA, Lieberman HR. A review of caffeine’s effects on cognitive, physical and occupational performance. Neurosci Biobehav Rev. 2016 Dec;71:294-312. doi: 10.1016/j.neubiorev.2016.09.001; https://pubmed.ncbi.nlm.nih.gov/27612937/
- Klaassen EB, de Groot RH, Evers EA, Snel J, Veerman EC, Ligtenberg AJ, Jolles J, Veltman DJ. The effect of caffeine on working memory load-related brain activation in middle-aged males. Neuropharmacology. 2013 Jan;64:160-7. doi: 10.1016/j.neuropharm.2012.06.026; https://pubmed.ncbi.nlm.nih.gov/22728314/
- Marcus L, et al; “Evaluation of the effects of two doses of alpha glycerylphosphorylcholine on physical and psychomotor performance;” J Int Soc Sports Nutr; 2017;14:39; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5629791/
- Hasselmo ME; “The role of acetylcholine in learning and memory;”Curr Opin Neurobiol. 2006;16(6):710–715; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2659740/
- Jones BE; “From waking to sleeping: neuronal and chemical substrates”. Trends Pharmacol. Sci.; 2005; 26 (11): 578–86; https://www.ncbi.nlm.nih.gov/pubmed/16183137
- Sanders LM, Zeisel SH; “Choline: Dietary Requirements and Role in Brain Development;” Nutrition today; 2007;42(4):181-186; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518394/
- Purves D, Augustine GJ, Fitzpatrick D, et al.; “Neuroscience;” 2nd edition. Sunderland (MA): Sinauer Associates; 2001. Acetylcholine. https://www.ncbi.nlm.nih.gov/books/NBK11143/
- Jones, Rachel. “An acetylcholine receptor keeps muscles in balance.” PLoS biology vol. 7,12 e1000268. 22 Dec. 2009, doi:10.1371/journal.pbio.1000268; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789318/
- Zeisel, Steven H. “Choline: Critical Role during Fetal Development and Dietary Requirements in Adults.” Annual Review of Nutrition, vol. 26, 2006, pp. 229–250, 10.1146/annurev.nutr.26.061505.111156; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441939/
- Kuksis, A., and S. Mookerjea. “Choline.” Nutrition Reviews, vol. 36, no. 7, 27 Apr. 2009, pp. 201–207, 10.1111/j.1753-4887.1978.tb07359.x; https://academic.oup.com/nutritionreviews/article-abstract/36/7/201/1831331
- Zeisel, S H, and J K Blusztajn. “Choline and Human Nutrition.” Annual Review of Nutrition, vol. 14, no. 1, July 1994, pp. 269–296, 10.1146/annurev.nu.14.070194.001413; https://pubmed.ncbi.nlm.nih.gov/7946521/
- da Costa, Kerry-Ann, et al. “Effects of Prolonged (1 Year) Choline Deficiency and Subsequent Re-Feeding of Choline on 1,2-Sn-Diradylglycerol, Fatty Acids and Protein Kinase c in Rat Liver.” Carcinogenesis, vol. 16, no. 2, 1995, pp. 327–334, 10.1093/carcin/16.2.327; https://academic.oup.com/carcin/article-abstract/16/2/327/348681
- Dodson WL, Sachan DS. Choline supplementation reduces urinary carnitine excretion in humans. Am J Clin Nutr. 1996;63(6):904-910. https://www.ncbi.nlm.nih.gov/pubmed/8644685
- Hongu N, Sachan DS. Carnitine and choline supplementation with exercise alter carnitine profiles, biochemical markers of fat metabolism and serum leptin concentration in healthy women. J Nutr. 2003;133(1):84-89. http://jn.nutrition.org/content/133/1/84.long
- Daily JW 3rd, Sachan DS. Choline supplementation alters carnitine homeostasis in humans and guinea pigs. J Nutr. 1995;125(7):1938-1944. https://www.ncbi.nlm.nih.gov/pubmed/7616311
- Elsawy G, Abdelrahman O, Hamza A. Effect of Choline Supplementation on Rapid Weight Loss and Biochemical Variables Among Female Taekwondo and Judo Athletes. Journal of Human Kinetics. 2014;40:77-82. doi:10.2478/hukin-2014-0009; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096089/
- Poly, Coreyann et al. “The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort.” The American journal of clinical nutrition vol. 94,6 (2011): 1584-91. doi:10.3945/ajcn.110.008938; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252552/
- “Choline and Fatty Liver Disease.” www.medicalnewstoday.com, 17 June 2022, http://www.medicalnewstoday.com/articles/how-much-choline-is-needed-to-reverse-fatty-liver
- Jacob J et al. “A randomized single dose parallel study on enhancement of nitric oxide in serum and saliva with the use of natural sports supplement in healthy adults.” Journal of Dietary Supplements, vol. 15, no. 2 (March 4, 2018): 161-172; https://www.ncbi.nlm.nih.gov/pubmed/28641022
- Gopi, S., Jacob, J., Varma, K. et al; “Natural sports supplement formulation for physical endurance: a randomized, double-blind, placebo-controlled study;” Sport Sci Health; 2017; 13, 183–194; https://link.springer.com/article/10.1007/s11332-017-0352-y#Abs1
- Goldstein, E.R., Ziegenfuss, T., Kalman, D. et al.; “International society of sports nutrition position stand: caffeine and performance”; J Int Soc Sports Nutr 7, 5 (2010); https://link.springer.com/article/10.1186/1550-2783-7-5
- Norager, C. B., et al. “Metabolic Effects of Caffeine Ingestion and Physical Work in 75-Year Old Citizens. A Randomized, Double-Blind, Placebo-Controlled, Cross-over Study.” Clinical Endocrinology, vol. 65, no. 2, Aug. 2006, pp. 223–228, 10.1111/j.1365-2265.2006.02579.x; https://pubmed.ncbi.nlm.nih.gov/16886964/
- Astrup, A, et al. “Caffeine: A Double-Blind, Placebo-Controlled Study of Its Thermogenic, Metabolic, and Cardiovascular Effects in Healthy Volunteers.” The American Journal of Clinical Nutrition, vol. 51, no. 5, 1 May 1990, pp. 759–767, 10.1093/ajcn/51.5.759; https://academic.oup.com/ajcn/article/51/5/759/4695347
- Keijzers, Gerben B., et al. “Caffeine Can Decrease Insulin Sensitivity in Humans.” Diabetes Care, vol. 25, no. 2, 1 Feb. 2002, pp. 364–369; https://care.diabetesjournals.org/content/25/2/364.long
- Reyes-Izquierdo, Tania, et al. “Modulatory Effect of Coffee Fruit Extract on Plasma Levels of Brain-Derived Neurotrophic Factor in Healthy Subjects.” The British Journal of Nutrition, vol. 110, no. 3, 28 Aug. 2013, pp. 420–425, 10.1017/S0007114512005338. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/modulatory-effect-of-coffee-fruit-extract-on-plasma-levels-of-brain-derived-neurotrophic-factor-in-healthy-subjects/8B291E8D053143AA5A8D33B65496B034
- Phillips, Cristy. “Brain-Derived Neurotrophic Factor, Depression, and Physical Activity: Making the Neuroplastic Connection.” Neural Plasticity, vol. 2017, 2017, pp. 1–17, 10.1155/2017/7260130; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591905/
- Miranda, Magdalena, et al. “Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain.” Frontiers in Cellular Neuroscience, vol. 13, 7 Aug. 2019, 10.3389/fncel.2019.00363; https://www.frontiersin.org/articles/10.3389/fncel.2019.00363/full
- Lu, B et al. “BDNF and synaptic plasticity, cognitive function, and dysfunction.” Handbook of experimental pharmacology vol. 220 (2014): 223-50. doi:10.1007/978-3-642-45106-5_9; https://link.springer.com/chapter/10.1007/978-3-642-45106-5_9
- Piepmeier, Aaron T., and Jennifer L. Etnier. “Brain-Derived Neurotrophic Factor (BDNF) as a Potential Mechanism of the Effects of Acute Exercise on Cognitive Performance.” Journal of Sport and Health Science, vol. 4, no. 1, 1 Mar. 2015, pp. 14–23; 10.1016/j.jshs.2014.11.001; https://www.sciencedirect.com/science/article/pii/S2095254614001161
- Nicastri, Casey M., et al. “BDNF Mediates Improvement in Cognitive Performance after Computerized Cognitive Training in Healthy Older Adults.” Alzheimer’s & Dementia: Translational Research & Clinical Interventions, vol. 8, no. 1, Jan. 2022, 10.1002/trc2.12337; https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12337
- Zuccato, Chiara, and Elena Cattaneo. “Brain-Derived Neurotrophic Factor in Neurodegenerative Diseases.” Nature Reviews Neurology, vol. 5, no. 6, June 2009, pp. 311–322, 10.1038/nrneurol.2009.54; https://www.nature.com/articles/nrneurol.2009.54
- Martínez-Pinilla E, Oñatibia-Astibia A, Franco R. “The relevance of theobromine for the beneficial effects of cocoa consumption”; Front Pharmacol. 2015;6:30; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335269/
- Khazan, Marjan et al; “Identification and determination of synthetic pharmaceuticals as adulterants in eight common herbal weight loss supplements.”; Iranian Red Crescent medical journal; vol. 16,3; 2014; e15344; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005444/
- Baggott, M, et. al; “Psychopharmacology of theobromine in healthy volunteers”; Psychopharmacology; February 2013; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672386/
- Stohs, Sidney J., et al. “A Review of the Human Clinical Studies Involving Citrus Aurantium (Bitter Orange) Extract and Its Primary Protoalkaloid P-Synephrine.” International Journal of Medical Sciences, vol. 9, no. 7, 2012, pp. 527–538, 10.7150/ijms.4446. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444973/
- Schena, Giorgia, and Michael J. Caplan. “Everything You Always Wanted to Know about β3-AR * (* but Were Afraid to Ask).” Cells, vol. 8, no. 4, 16 Apr. 2019, p. 357, 10.3390/cells8040357. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523418/
- Gutiérrez-Hellín, Jorge, and Juan Del Coso. “Acute P-Synephrine Ingestion Increases Fat Oxidation Rate during Exercise.” British Journal of Clinical Pharmacology, vol. 82, no. 2, 7 May 2016, pp. 362–368, 10.1111/bcp.12952. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972152/
- Ratamess, Nicholas A., et al. “The Effects of Supplementation with P-Synephrine Alone and in Combination with Caffeine on Resistance Exercise Performance.” Journal of the International Society of Sports Nutrition, vol. 12, no. 1, 17 Sept. 2015, 10.1186/s12970-015-0096-5; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573476
- Tang, X. C., et al. “Effect of Huperzine A, a New Cholinesterase Inhibitor, on the Central Cholinergic System of the Rat.” Journal of Neuroscience Research, vol. 24, no. 2, 1 Oct. 1989, pp. 276–285, 10.1002/jnr.490240220. https://pubmed.ncbi.nlm.nih.gov/2585551/
- Damar, U., et al. “Huperzine a as a Neuroprotective and Antiepileptic Drug: A Review of Preclinical Research.” Expert Review of Neurotherapeutics, vol. 16, no. 6, 1 June 2016, pp. 671–680, 10.1080/14737175.2016.1175303. https://pubmed.ncbi.nlm.nih.gov/27086593/
- [vi] Gao X., Tang X.C. “Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.”Journal of Neuroscience Research. 2006 May 1;83(6):1048-57; https://pubmed.ncbi.nlm.nih.gov/16493671/