After stumbling across Advanced Molecular Labs, we’ve really become intrigued by a number of their intelligently assembled supplements. We’ve previously gone into great detail about AML’s Pre Workout which is a true strength and power-based performance pre workout. Today, we take a look at the brand’s advanced night time fat burner.
Thermo Heat Nighttime is a truly innovative thermogenic supplement that boosts metabolism, mitigates stress, and promotes better sleep.
The quick review is that this is the most effective nighttime fat burner we’ve tried, although we’ve only tried two, and is definitely worth a look. A more thorough review is after our ingredient discussion.
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Thermo Heat Nighttime Ingredients
As we stated up top, Thermo Heat Nighttime is a truly one of a kind fat burner that looks to amp up your body’s natural fat burning processes overnight while simultaneously improving your quality of sleep. Ultimately, you should wake up feeling noticeably leaner and better rested than with any other nighttime thermogenic you’ve tried before.
Thermo Heat® Proprietary Blend (1.55g)
GABA is the body’s primary inhibitory neurotransmitter, and commonly known as the “downer” neurotransmitter. It’s main action is countering the excitatory effects of glutamate in the brain and typically provides a sense of controlled calm during stressful situations.
Other studies note GABA’s ability to increase Growth Hormone (GH) release, particularly in the post workout window. The release of GH stimulates triglyceride hydrolysis in adipose tissue which basically encourages the body to pull fat from the “goo” around your abdomen and use that as a source of fuel.
However, this is likely here primarily for the improved sleep aspect, as it is one of our ingredients on our Best Sleep Aid guide.
5-hydroxytryptophan, 5-HTP, is a precursor to serotonin most commonly used to provide a feeling of euphoria and overall contentment. Having adequate levels of serotonin results in increased production of melatonin (more on this later), and since 5-HTP is required to produce serotonin, it only makes sense that supplementing with 5-HTP leads to greater melatonin levels, ultimately resulting in better quality sleep thanks to improved circadian rhythms.
That’s not the end of the story though as 5-HTP taken around bedtime helps induce sleep and improve overall sleep quality. 5-HTP is a pretty cool ingredient on its own, but if you really want to take it up another notch consider adding some valerian on the side as consuming the two together has been documented to enhance sleep quality and reduce shorten the time to fall asleep as well as stress.[3,4]
One of the most popular and fastest growing relaxation supplements is the amino acid L-Theanine. It’s found found its way into an ever-growing number of products, especially in the pre workout category. L-Theanine is predominantly found in tea leaves (Camellia sinensis), and when used alongside with caffeine, it magnifies the focus-boosting properties of caffeine as well as help “take the edge off” higher doses of the popular stim.
But, this is a nighttime supplement, so you won’t find any caffeine here, so what else can L-Theanine do?
Well, when taken alone, it induces a tremendous calming sensation[5,6] – best described as an incredibly “relaxing” or “chill” sensation. L-Theanine is a fantastic relaxant, and if the above dose of GABA is dosed adequately, you’ll be melting into the soothing arms of sleep well within a half hour of ingesting it.
Now that sleep is covered, it’s time to burn some fat:
Ginger Root Extract (5% gingerols)
Ginger is typically seen as a flavoring component numerous Asian recipes and the occasional baked goodie. In addition to its potent flavor, ginger is also loaded with a collection of compounds known as gingerols, with 6-gingerol being the one we’re most interested in due to its fat burning abilities.
6-gingerol activates the peroxisome proliferator-activated receptor δ (PPARδ), which can accelerate weight loss by increasing energy expenditure and the “browning” of white fat.[7,8,9]
Results from these clinical studies note decreased levels of glucose, leptin, insulin, and lipids compared to control as well as markedly reduced body weight. In plain English, the active fat-burning component of ginger root is incredibly effective for combating weight gain, obesity and the collection of negative markers associated with the two.
The main driver of the Thermo-Heat Family
This is what we believe to be the primary ingredient here. If you’re a fan of ginger, or have never tried a serious ginger-based fat burner, you should try at least one of the Thermo Heat products (there’s also the stimulant-based Thermo Heat fat burner and the Thermo Heat Multivitamin) – they all have this mix in it.
Cinnamon Bark Extract
Another frequently used spice and component of baked treats is the incredibly fragrant cassia bark extract, more commonly known as cinnamon. This spice contains a number of MethylHydroxyChalcone polymers (MHCPs) that shown great benefit when it comes to improving insulin sensitivity.
Additionally, cinnamon extract has been thoroughly investigated for its benefits treating people with Type 2 Diabetes. In particular, cinnamon is able to mimic insulin and lower glucose levels when consumed prior to a meal.
Cayenne Pepper Extract
Ginger wasn’t enough heat for you?
If you’re a fiend for spicy food, particularly Cajun / Creole cooking, you’re well acquainted with our next ingredient Cayenne Pepper Extract. It’s backed by some solid research showcasing it as a powerful fat oxidizer. The potent little compound responsible for giving cayenne pepper, and all chiles, their bite is a chemical known as capsaicin. In addition to setting your taste buds ablaze, this fruit extract also burns stored fat and increases overall energy expenditure.
AML has made the smart move of using a capsule delivery form for Thermo Heat Nighttime. Putting this particular ingredient in a powder can often times lead to heartburn and other unwanted GI distress. Capping the powder sidesteps these unwanted consequences so you get all the benefits of cayenne pepper without the burn!
Melatonin is a naturally produced hormone secreted by that brain that helps governs the sleep cycle, also known as your circadian rhythm. Optimal doses for improving sleep vary widely between 500mcg to 5mg, and we’ve even seen some products go as high as 20mg!.
However, more melatonin doesn’t always equal longer / better sleep to longer or better quality of sleep. One study in particular found that a 500mcg dose was more effective in regulating the sleep cycle of the participants than a 20mg dose.
If we’re being blunt, melatonin dosing for sleep purposes is extremely dependent on the person – some people like a lot, others just a touch. If we’re talking about pure fat-burning and muscle building benefits though, a 5mg dose has been documented to increase Growth Hormone levels post ingestion significantly more than 500mg.
Finally, we have the wildly popular black pepper extract used in everything from pre workouts to fat burners and everything in between, BioPerine®. This patented ingredient helps improve the bioavailability and absorption of all the other ingredients in dietary supplements by inhibiting their breakdown in the body, ultimately prolonging their lifespan in the GI system ensuring maximum absorption.
There’s fat burning benefit to BioPerine® as well! Piperine, the compound inside black pepper that gives it its “pop”, also can raise epinephrine (adrenaline) levels. Research has shown that this increase in adrenaline levels ultimately increases energy expenditure and therefore burns more calories.
Take 2 Thermo Heat® Nighttime capsules 30 minutes before evening meal or before bedtime. Do not consume more than 2 capsules daily.
One of the reasons why I like staying in the 12-15% bodyfat range is because I can really test and tweak different diet tactics and fat burners and see the difference, while not being too much of a maniac on the diet. And if I need to get to 10%, it’s only a few weeks away.
Thermo Heat Nighttime is one of those products that legitimately, visibly works. Even though I always wake up lighter than when I fell asleep — especially after hitting the restroom when I get up — this product is special. Every time I remember to take it, I wake up more refreshed but also a bit ‘tighter’ than normal. It’s impressive.
I almost always sleep better on it too… except once: one night, out of the 15 or so times I’ve used this, I didn’t fully swallow the capsule. It must have gotten stuck in my throat or upper digestive tract. And once that capsule opened up, the ginger and other ingredients gave me heartburn that you would not believe.
So while it’s not stimulatory, this stuff is extremely potent — but swallow that pill all the way!!
Granted, I’ve only seriously tried two nighttime fat burners, the other being Magnum’s After Burner. I found Thermo Heat Nighttime to be more effective, while After Burner’s hops did make me sleep a bit deeper. Thermo Heat’s GABA and 5-HTP has been nice on the sleep front though – this is my first time taking 5-HTP before bed (I usually don’t have sleep problems) and it seems to kick things to the next gear.
I have a feeling women would love this. Noticeably waking up tighter is great, and the non-stimulatory, all natural ingredients has a great spin to it too. But if you’re obese, I’m not sure you’ll “notice” the changes like I do, but I do believe that it really works.
The biggest challenge is remembering to take it before bed. You need to remember to make it part of your routine, and I keep failing at that.
Other Thermo Heat Supplements from AML
As mentioned in the Ginger section above, there’s also the stimulant-based Thermo Heat fat burner and the Thermo Heat Multivitamin. These also have the thermogenic portion that the Nighttime product here has — the multivitamin’s thermo dosage is likely smaller than the actual fat burner’s — so if you want to try the cayenne / ginger “brown fat” combo out, then consider those as well.
Fat burners are typically used only during the day time, but that’s leaving a good 8-10 hours each day that you’re not getting the maximum benefits from this type of supplement due to the requirements of sleep. However, consuming a fat burner that’s specifically formulated to take advantage of the inherent fat burning and muscle growing hormonal actions enables you to be a fat shredding machine 24/7.
If you don’t sleep as deep as you want, or you think you could benefit from the brown fat activating ingredients like this strong dose of ginger, then this could hit the other end of your fat burning schedule that you’ve been ignoring.
AML’s Thermo-Heat Nighttime is the perfect PM counterpart to your favorite fat burner or the daytime Thermo Heat fat burner that you typically consume starting in the morning. If you’re anything like us, you’ll ultimately wake up more well rested and sporting a slimmer physique come morning time. Just don’t forget to take it!
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- Petroff OA; GABA and glutamate in the human brain . Neuroscientist. (2002)
- Shell, W; A randomized, placebo-controlled trial of an amino acid preparation on timing and quality of sleep.; Am J Ther. 2010 Mar-Apr;17(2):133-9.; Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/19417589
- Emanuele E, et al; An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress . Neuro Endocrinol Lett. (2010)
- Higashiyama, A; Effects of l-theanine on attention and reaction time response; University of Shiga Prefecture, Human Culture Department; 2010; Retrieved from http://www.sciencedirect.com/science/article/pii/S1756464611000351
- Lu, K; The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans; Human Psychopharmacology, 19 7: 457-465; 2004;; Retrieved from http://espace.library.uq.edu.au/view/UQ:284103
- Wang S et al. Nat Prod Commun. 2014 Jul;9(7):1027-30. Biological properties of 6-gingerol: a brief review.
- Misawa K et al. J Nutr Biochem. 2015 Oct;26(10):1058-67. doi: 10.1016/j.jnutbio.2015.04.014. Epub 2015 May 28. Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway.
- Saravanan G et al. J Sci Food Agric. 2014 Nov;94(14):2972-7. doi: 10.1002/jsfa.6642. Epub 2014 Apr 7. Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet.
- A Hydroxychalcone Derived from Cinnamon Functions as a Mimetic for Insulin in 3T3-L1 Adipocytes
- Gruenwald, J. et. al.; Critical Reviews in Food Science and Nutrition; “Cinnamon and health;” 2010
- Janssens, P, et. al; “Acute Effects of Capsaicin on Energy Expenditure and Fat Oxidation in Negative Energy Balance“; July 2013
- Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period
- Forsling ML, Wheeler MJ, Williams AJ; The effect of melatonin administration on pituitary hormone secretion in man . Clin Endocrinol (Oxf). (1999)
- Shoba, G., Joy, D., Joseph, T., Majeed, M., Rajendran, R., and Srinivas, P.S.S.R. (1998) Influence of Piperine on the pharamacokinetics of curcumin in animals and human volunteers. Planta Med. 64(4); 353-356