5% Nutrition’s Liver & Organ Defender Brings ON Cycle Protection!

image_pdfimage_print

Fans of Rich Piana know that he was never a fan of the conventional. While most supplement companies are happy to get by marketing workout supplements, Rich and 5% Nutrition innovated in more ways than we can count — and one of them was with all-inclusive health supplements that are all the range over 6 years after this one originally came out!

5% Nutrition Liver and Organ Defender

Back before these crazy organ health supplements were everywhere, one man and his company innovated them: Rich Piana and 5% Nutrition. Now it’s updated for the white legendary look, and we’ve updated this article with more research.

5% Nutrition’s Liver and Organ Defender contains ingredients that will protect the organs that are important to everyone — but especially vital to most bodybuilders. This means supporting your liver, heart, kidneys, prostate, and even your skin to keep them functioning optimally no matter what you put your body through!

On cycle support with Rich Piana’s Liver and Organ Defender

We recently covered the newer 5% Nutrition Post Gear supplement, which is to be used as an adjunct support supplement alongside your post cycle therapy regimen. However, this one’s for on cycle support, and it brings the house – with nine capsules to be taken per day (three capsules, three times a day with meals).

Liver and Organ Defender is a no-joke health support supplement. But what’s even crazier is that Rich Piana saw the future with formulas like this one. These types of health formulas are now becoming commonplace in the sports nutrition market. But Rich was there first — and it’s still just as good as it ever was! Only now, the label’s been updated to the white Legendary series, just like All Day You May, Kill It Reloaded, and many others to come.

What does Rich have in store for us? We’ll get to that in a second, but first take a second to sign up for PricePlow alerts and sign up for the best deal:

Liver and Organ Defender – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

Liver & Organ Defender Ingredients

Packed in nine capsules (yes, nine – space them out across three meals!) you will get all of the following:

  • Heart Support

    • Hawthorn Berry (Crataegus laevigata)(fruit) powder – 1,100 mg

      5% Nutrition Liver and Organ Defender Ingredients

      As big and bold as ever, the 5% Nutrition Liver and Organ Defender Ingredients come in nine capsules, split three times a day with meals

      Various species of the hawthorn plant have been used as a natural heart remedy for centuries. More recent studies have shown that it’s effective in treating arrhythmias and congestive heart failure[1,2] as well as hypertension.[3,4]

      This is why we sometimes see it in nitric oxide boosting supplements, so you may get an additional off-label benefit there as well. Reason being, hawthorn extract can help expand blood vessels by increasing the release of nitric oxide.[3,4] It’s been shown to lower both systolic and diastolic blood pressure in subjects with moderately high blood pressure.[4]

    • Alpha-Lipoic Acid – 400 mg

      Known as ALA, alpha lipoic acid is a fatty acid that resides in the mitochondria that is involved in energy metabolism. It terms of heart-health benefits, ALA improves blood flow and improves the function of the muscles that line the blood vessels of the heart.[5]

      Rich Piana Freak Show

      Love carbs and need to drive them home? Then join the FREAK SHOW, which also has ALA

      We recently covered another form of Alpha Lipoic acid in our article on 5% Nutrition’s Freak Show (a glucose disposal agent supplement for carb-lovers), since there are benefits with regards to high blood sugar levels, its antioxidant activity, and its ability to stimulate AMPK for energy.[6-14] These benefits are not directly linked to heart health, but are absolutely paramount in terms of supporting greater organ health in general.

      ALA is an underrated ingredient and we’re excited to see it dosed so well here.

      Note: don’t confuse this ALA with alpha linolenic acid, which is an omega-3 fatty acid that is different from this.

    • Garlic (Allium sativum L.)(bulb) Extract – 300 mg

      Garlic provides numerous benefits in terms of heart health. Garlic helps protect against abnormal heart growth,[15] atherosclerosis,[16] and high blood pressure.[17]

      Additional immunity!

      Garlic also provides great immunity benefits, which is important to keeping your organs running properly. Recently, we’ve learned that garlic has outperformed popular antiviral drugs in terms of reducing parasitic load,[18] and is known to inhibit some coronaviruses that cause bronchitis.[19] One of its incredible mechanisms is that it can inhibit ACE-2 docking.[20]

      This is why we highly recommend garlic when feeling under the weather, but it’s great to see it in an organ-supporting supplement as well.

    • DiMagnesium Malate – 250 mg

      5% Nutrition Liver and Organ Defender

      5% Nutrition’s Liver and Organ Defender now sports an incredible-looking Legendary white bottle

      Magnesium is an essential mineral the body needs to perform over 300 of functions! Next to Vitamin D, it’s the second most common nutrient deficiency in people.[21]

      With regards to heart health, low levels of magnesium can lead to elevated blood pressure and impaired cardiac function.[22,23] It’s also extremely important for proper insulin sensitivity and good blood glucose control.[24-26]

      To keep your ticker pumping on all cylinders, it’s of utmost importance to get your daily needs of magnesium – and this alone may not be enough depending on your diet, so make sure you consider a bit more before bed.

    • Ubidecarenone (Co-Q10) – 25 mg

      Coenzyme Q10 (also known as ubidecarenone and CoQ10) is a compound found in the mitochondria that supports energy metabolism. In terms of heart health, it can improve cardiac function, blood flow, and raise HDL (good) cholesterol levels.[27-29]

      There are literally entire books written about how CoQ10 can help the heart, so we’re clearly just scratching the surface here. If looking for an incredible all-encompassing free review that details the majority of its benefits, see the paper published in The Journal of Pharmacy and Bioallied Sciences titled “Coenzyme Q10: The Essential Nutrient”.[30]

  • Liver Support

    You can’t have a liver support supplement without great doses of these first two ingredients:

    • N-Acetyl L-Cysteine – 1,000 mg

      N-Acetyl Cysteine (NAC) is the main substrate for glutathione, which you’ll also find in this complex. Through the buffering of glutathione, NAC confers many benefits in regards to protecting the liver and providing antioxidant support to the body.[31,32]

      The benefits of NAC are vast, and to cover a majority of them, we suggest reading the 2017 review titled “A Review on Various Uses of N-Acetyl Cysteine” that was published in Cell.[33] One of the areas of focus is how NAC helps treat and protect against acetaminophen hepatotoxicity.[34,35]

      Many may appreciate how NAC is helpful in fighting alcohol toxicity.[36-39]

    • Milk Thistle Powder (Seed) – 600 mg

      5% Nutrition Post Gear

      5% Nutrition Post Gear is a PCT Support Supplement that has a few new things and should bring you a few very fun weeks – even after the cycle’s over!

      Covered in depth in our 5% Nutrition Post Gear article, 5% Nutrition put three times the amount of milk thistle here in Organ and Liver Defender, although this one is likely more of a full-spectrum.

      In that article, we focus on this “liver tonic”[40] and the numerous consequences it can protect against:

      1. Fighting drug-induced liver disease[41-43]
      2. Improve liver function after alcohol abuse[44-49]
      3. Improvements against general liver toxicity (cohort studies)[50-52]
      4. Protection from environmental toxins[53]
      5. Added meta analyses for other liver diseases[54,55]

      A lot of the research was performed in Germany in the 1970s, and not all has been translated, but we’re extraordinarily confident in milk thistle as a liver detoxification ingredient – especially at this large of a dose.

    • L-Glutathione (TwinTiger) – 30 mg

      Glutathione is a non-essential amino acid that is vital to removing free radicals from the body.[56,57] Many consider it the master antioxidant. However, the body’s production of glutathione is limited by how much cysteine is available, which is why supplementing N-Acetyl Cysteine is so beneficial.

      Most products include one or the other, with most using NAC since glutathione isn’t very orally bioavailable.[58] However, it still may provide some benefits, and we love Rich Piana’s go big or go home approach — why not do both?! This makes a strong one-two punch in liver protection through this pathway.

  • Prostate Support

    • Saw Palmetto (Serenoa repens)(berry) – 1,000 mg

      5% Nutrition All Day You May

      LEGENDARY Status: 5% Nutrition’s All Day You May also moved to the white tub, and the formula was also mostly unchanged. See how Rich Piana shattered the industry with this supplement, especially with that Southern Sweet Tea flavor!

      All guys know keeping prostate growth at bay becomes increasingly more important as the years go by. Enlarged prostate is one of the earliest signs of prostate cancer. Fortunately, 5% Nutrition includes saw palmetto to suppress prostate growth.[59,60]

      This has been known for quite some time – a 1998 meta analysis looked at 18 different randomized controlled trials on nearly 3,000 males, and found that the ingredient consistently improves peak urinary flow and reduces nighttime urination and lowers urinary tract symptom scores.[60] It even compares well to popular prescription drugs, but with fewer side effects![60]

      So if you’re tired of getting up in the middle of the night, or have urinary flow and bladder clearance that’s less-than-spectacular, this alone is worth a shot – and as always in this supplement, it’s no small dose!

  • Kidney Support

    • Cordyceps sinensis (whole) – 500 mg

      Cordyceps is a mushroom that was traditionally used in Chinese medicine as an anti-aging compound. More recently, it’s been included in supplements to aid the body in combating stress and delays the onset of fatigue.[61]

      However, with regards to Organ and Liver Defender, cordyceps has been shown to prevent proliferation of kidney cells.[62] It’s also been used to in renal transplant patients to ensure a successful implantation and offset any possibility the body’s internal defense systems attack the new organ.[63]

  • Skin Support

    Rich Piana Bald Eagle

    Heil to the true king of sports nutrition, who had some of the best skin in the industry!

    In both of the ingredients below, note that 5% Nutrition is using high-quality, bioavailable minerals that have been bound to amino acids for better uptake. Minerals are not traditionally absorbed well by the small intestine, but amino acids like glycine are — so binding them together gets you vastly improved uptake! We cannot emphasize this enough when looking at minerals like zinc.

    • Zinc Bisglycinate Chelate (TRAACS) – 300 mg (yielding 30 mg / 273%)

      Zinc is another essential mineral the body uses to regulate many enzymes and support the immune system.

      We repeatedly talk about its immune benefits, but what you may not realize is that zinc can do wonders for your skin! Not only can it help fight acne.[64], but it’s also beneficial in preventing the growth of warts (topical) and psoriasis.[65,66]

      With regards to absorption, the glycine-bound form of zinc here has outperformed other popular forms like zinc oxide (which is awful), zinc gluconate, and zinc sulfate in humans[67,68] and animals.[69]

    • Selenium Glycinate (Albion) – 7,000 mcg (yielding 70 mcg / 127% DV)

      Our final ingredient in this protective tour de force is another essential mineral for the body. In addition to helping give you a shiny coat, selenium can improve skin elasticity and prevent the spread of acne — especially when paired with NAC and milk thistle, which are both in here as well![70]

Dosing

Rich Piana Full as F*ck

The Legendary Series at 5% Nutrition just got a boost with this one. Follow along in our 5% Nutrition news page.

Remember, this is to be used for on cycle support — if you’re in a post-cycle status, take a look at 5% Nutrition Post Gear.

To get maximum protection for those vital organs, you’ll need to pop nine of these capsules throughout the day – but if you couldn’t tell, there are a lot of well-dosed ingredients here! This is also nothing too new for on-cycle or post-cycle type supplements.

Thankfully, it’s only three capsules, three times a day. Just don’t forget! If you do miss a dose, we’d personally double the next one, but do not get into that habit. Keep these ingredients flowing nice and steady.

By covering so many bases, 5% Nutrition provides an excellent start to those who need to pair their over-the-counter and prescription-based PCTs with additional liver and heart support that is so badly needed by the most “aggressive” of hormone users.

5% Nutrition knows how to defend organs and livers

Rich Piana Whatever It Takes

Whatever it takes to keep those organs strong and healthy!

Rich Piana and 5% Nutrition have continued their trend providing unique and intriguing supplements that work inside and out of our time in the weight room. There are definitely some overlaps in our recent Post Gear article, but Organ and Liver Defender has less room used on testosterone-enhancing ingredients and more on organ support.

Far too many lifters are only interested in the one hour(s) spent in the gym, and not on the 23 (22?) spent recovering and growing. Far too many lifters are worried about their cycle but not supporting any potential wreckage caused throughout the rest of their body.

This supplement was formulated in 2015, and is still as legit as ever. Rich Piana and his crew take care of their “bros” who are too busy to worry about ensuring their optimal health by providing a catch-all supplement that will keep you fit and healthy long into your golden years!

Nine capsules is nothing when it comes to liver and organ health. Get it done and enjoy your gains.

Liver and Organ Defender – Deals and Price Drop Alerts

Get Price Alerts

No spam, no scams.

Disclosure: PricePlow relies on pricing from stores with which we have a business relationship. We work hard to keep pricing current, but you may find a better offer.

Posts are sponsored in part by the retailers and/or brands listed on this page.

Note: This article was originally published on August 21, 2015 and updated on September 30, 2021 with the switch to the Legendary white tubs. The ingredients are the same, but more research has been added here.

About the Author: Mike Roberto

Mike Roberto

Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is an n=1 diet experimenter with extensive experience in supplementation and dietary modification, whose personal expertise stems from several experiments done on himself while sharing lab tests.

Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

No Comments | Posted in , | Tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , .

References

  1. Degenring, F.H., et al. “A Randomised Double Blind Placebo Controlled Clinical Trial of a Standardised Extract of Fresh Crataegus Berries (Crataegisan) in the Treatment of Patients with Congestive Heart Failure NYHA II.” Phytomedicine, vol. 10, no. 5, Jan. 2003, pp. 363–369, 10.1078/0944-7113-00312; http://www.ncbi.nlm.nih.gov/pubmed/12833999
  2. Alp, Hayrullah, et al. “Protective Effects of Hawthorn (Crataegus Oxyacantha) Extract against Digoxin-Induced Arrhythmias in Rats.” Anatolian Journal of Cardiology, vol. 15, no. 12, 2015, pp. 970–5, 10.5152/akd.2014.5869; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5368468/
  3. Asher, G. et al. Mar. 2012. “Effect of Hawthorn Standardized Extract on Flow-Mediated Dilation in Prehypertensive and Mildly Hypertensive Adults: A Randomized, Controlled Cross-over Trial.” BMC Complementary and Alternative Medicine vol. 12; 26. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350435/
  4. Walker, A. et al. Feb. 2002. “Promising Hypotensive Effect of Hawthorn Extract: A Randomized Double-blind Pilot Study of Mild, Essential Hypertension.” Phytotherapy Research vol. 16,1; 48–54. https://pubmed.ncbi.nlm.nih.gov/11807965/
  5. Saller, R., et al. “An Updated Systematic Review with Meta-Analysis for the Clinical Evidence of Silymarin.” Forschende Komplementärmedizin / Research in Complementary Medicine, vol. 15, no. 1, 2008, pp. 9–20, 10.1159/000113648; https://pubmed.ncbi.nlm.nih.gov/18334810/
  6. Foster, T. (2007). Efficacy and Safety of α-Lipoic Acid Supplementation in the Treatment of Symptomatic Diabetic Neuropathy. The Diabetes Educator, 33(1), 111-117. doi: 10.1177/0145721706297450; https://www.ncbi.nlm.nih.gov/pubmed/17272797
  7. Porasuphatana, S., Suddee, S., Nartnampong, A., Konsil, J., Harnwong, B., & Santaweesuk, A. (2012). Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. Asia Pacific Journal of Clinical Nutrition, 21(1), 12–21. https://www.ncbi.nlm.nih.gov/pubmed/22374556
  8. Gupte, A. A., Bomhoff, G. L., Morris, J. K., Gorres, B. K., & Geiger, P. C. (2009). Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats. Journal of Applied Physiology, 106(4), 1425–1434; https://www.ncbi.nlm.nih.gov/pubmed/19179648
  9. Winder, W. W., & Hardie, D. G. (1999). AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes. American Journal of Physiology-Endocrinology and Metabolism, 277(1), E1–E10; https://www.ncbi.nlm.nih.gov/pubmed/10409121
  10. Kola, B. (2008). Role of AMP-Activated Protein Kinase in the Control of Appetite. Journal of Neuroendocrinology, 20(7), 942–951; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658714/
  11. Kim, M.-S., Park, J.-Y., Namkoong, C., Jang, P.-G., Ryu, J.-W., Song, H.-S., … Lee, K.-U. (2004). Anti-obesity effects of α-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nature Medicine, 10(7), 727–733. https://www.ncbi.nlm.nih.gov/pubmed/15195087
  12. Hagen, T, et al. (1999). (R)-α-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. The FASEB Journal, 13(2), 411-418; https://www.ncbi.nlm.nih.gov/pubmed/9973329
  13. Jariwalla, R., Lalezari, J., Cenko, D., Mansour, S., Kumar, A., Gangapurkar, B., & Nakamura, D. (2008). Restoration of Blood Total Glutathione Status and Lymphocyte Function Following α-Lipoic Acid Supplementation in Patients with HIV Infection. The Journal Of Alternative And Complementary Medicine, 14(2), 139-146; https://www.ncbi.nlm.nih.gov/pubmed/18315507
  14. Khabbazi, T., Mahdavi, R., Safa, J., & Pour-Abdollahi, P. (2012). Effects of Alpha-Lipoic Acid Supplementation on Inflammation, Oxidative Stress, and Serum Lipid Profile Levels in Patients With End-Stage Renal Disease on Hemodialysis. Journal Of Renal Nutrition, 22(2), 244-250. doi: 10.1053/j.jrn.2011.06.005; https://www.ncbi.nlm.nih.gov/pubmed/21908204
  15. Chang, Sheng-Huang, et al. “Garlic Oil Alleviates MAPKs- and IL-6-Mediated Diabetes-Related Cardiac Hypertrophy in STZ-Induced DM Rats.” Evidence-Based Complementary and Alternative Medicine : ECAM, vol. 2011, 2011, 10.1093/ecam/neq075; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3137822/
  16. Budoff, M. “Inhibiting Progression of Coronary Calcification Using Aged Garlic Extract in Patients Receiving Statin Therapy: A Preliminary Study*1.” Preventive Medicine, vol. 39, no. 5, Nov. 2004, pp. 985–991, 10.1016/j.ypmed.2004.04.012; https://pubmed.ncbi.nlm.nih.gov/15475033/
  17. Adler, A J, and B J Holub. “Effect of Garlic and Fish-Oil Supplementation on Serum Lipid and Lipoprotein Concentrations in Hypercholesterolemic Men.” The American Journal of Clinical Nutrition, vol. 65, no. 2, 1 Feb. 1997, pp. 445–450, 10.1093/ajcn/65.2.445; https://pubmed.ncbi.nlm.nih.gov/9022529/
  18. Ayaz, Erol, et al. “Evaluation of the Anthelmentic Activity of Garlic (Allium Sativum) in Mice Naturally Infected with Aspiculuris Tetraptera.” Recent Patents on Anti-Infective Drug Discovery, vol. 3, no. 2, 1 June 2008, pp. 149–152, 10.2174/157489108784746605; https://pubmed.ncbi.nlm.nih.gov/18673129/
  19. Mohajer Shojai, Tabassom, et al. “The Effect of Allium Sativum (Garlic) Extract on Infectious Bronchitis Virus in Specific Pathogen Free Embryonic Egg.” Avicenna Journal of Phytomedicine, vol. 6, no. 4, 2016, pp. 458–267; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967842/
  20. Thuy, Bui Thi Phuong, et al. “Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil.” ACS Omega, vol. 5, no. 14, 31 Mar. 2020, pp. 8312–8320, 10.1021/acsomega.0c00772; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123907/
  21. Jacka, Felice N., et al. “Association between Magnesium Intake and Depression and Anxiety in Community-Dwelling Adults: The Hordaland Health Study.” Australian & New Zealand Journal of Psychiatry, vol. 43, no. 1, Jan. 2009, pp. 45–52, 10.1080/00048670802534408; https://pubmed.ncbi.nlm.nih.gov/19085527/
  22. Mathers, Tavia W., and Renea L. Beckstrand. “Oral Magnesium Supplementation in Adults with Coronary Heart Disease or Coronary Heart Disease Risk.” Journal of the American Academy of Nurse Practitioners, vol. 21, no. 12, Dec. 2009, pp. 651–657, 10.1111/j.1745-7599.2009.00460.x; https://pubmed.ncbi.nlm.nih.gov/19958415/
  23. Corica, F., et al. “Magnesium Concentrations in Plasma, Erythrocytes, and Platelets in Hypertensive and Normotensive Obese Patients.” American Journal of Hypertension, vol. 10, no. 11, 1 Nov. 1997, pp. 1311–1313, 10.1016/s0895-7061(97)00313-0; https://pubmed.ncbi.nlm.nih.gov/9397253/
  24. Rodriguez-Moran, M., and F. Guerrero-Romero. “Oral Magnesium Supplementation Improves Insulin Sensitivity and Metabolic Control in Type 2 Diabetic Subjects: A Randomized Double-Blind Controlled Trial.” Diabetes Care, vol. 26, no. 4, 1 Apr. 2003, pp. 1147–1152, 10.2337/diacare.26.4.1147; https://care.diabetesjournals.org/content/26/4/1147.long
  25. Guerrero-Romero, Fernando, and Martha Rodríguez-Morán. “Magnesium Improves the Beta-Cell Function to Compensate Variation of Insulin Sensitivity: Double-Blind, Randomized Clinical Trial.” European Journal of Clinical Investigation, vol. 41, no. 4, 17 Jan. 2011, pp. 405–410, 10.1111/j.1365-2362.2010.02422.x; https://pubmed.ncbi.nlm.nih.gov/21241290/
  26. Mooren, F. C., et al. “Oral Magnesium Supplementation Reduces Insulin Resistance in Non-Diabetic Subjects – a Double-Blind, Placebo-Controlled, Randomized Trial.” Diabetes, Obesity and Metabolism, vol. 13, no. 3, 24 Jan. 2011, pp. 281–284, 10.1111/j.1463-1326.2010.01332.x; https://pubmed.ncbi.nlm.nih.gov/21205110/
  27. Rosenfeldt, Franklin, et al. “Coenzyme Q10 Therapy before Cardiac Surgery Improves Mitochondrial Function and in Vitro Contractility of Myocardial Tissue.” The Journal of Thoracic and Cardiovascular Surgery, vol. 129, no. 1, 1 Jan. 2005, pp. 25–32, 10.1016/j.jtcvs.2004.03.034; https://pubmed.ncbi.nlm.nih.gov/15632821/
  28. Watts, G. F., et al. “Coenzyme Q10 Improves Endothelial Dysfunction of the Brachial Artery in Type II Diabetes Mellitus.” Diabetologia, vol. 45, no. 3, Mar. 2002, pp. 420–426, 10.1007/s00125-001-0760-y; https://pubmed.ncbi.nlm.nih.gov/11914748/
  29. Mabuchi, Hiroshi, et al. “Effects of CoQ10 Supplementation on Plasma Lipoprotein Lipid, CoQ10 and Liver and Muscle Enzyme Levels in Hypercholesterolemic Patients Treated with Atorvastatin: A Randomized Double-Blind Study.” Atherosclerosis, vol. 195, no. 2, Dec. 2007, pp. e182–e189, 10.1016/j.atherosclerosis.2007.06.010; https://pubmed.ncbi.nlm.nih.gov/17681347/
  30. Saini, R. Sept. 2011. “Coenzyme Q10: The Essential Nutrient.” Journal of Pharmacy and Bioallied Sciences vol. 3,3; 466-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178961/
  31. Ozaras, Resat, et al. “N-Acetylcysteine Attenuates Alcohol-Induced Oxidative Stress in the Rat.” World Journal of Gastroenterology, vol. 9, no. 1, 2003, p. 125, 10.3748/wjg.v9.i1.125; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4728225/
  32. Caro, Andres A., et al. “N-Acetylcysteine Inhibits the Upregulation of Mitochondrial Biogenesis Genes in Livers from Rats Fed Ethanol Chronically.” Alcoholism, Clinical and Experimental Research, vol. 38, no. 12, 1 Dec. 2014, p. 2896, 10.1111/acer.12576; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4293075/
  33. Mokhtari, Vida et al; “A Review on Various Uses of N-Acetyl Cysteine.”; Cell journal; vol. 19,1; 2017; 11-17; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/
  34. Crowell, Christopher, et al. “Caring for the Mother, Concentrating on the Fetus: Intravenous N-Acetylcysteine in Pregnancy.” The American Journal of Emergency Medicine, vol. 26, no. 6, 1 July 2008, pp. 735.e1-2, 10.1016/j.ajem.2007.11.017; https://pubmed.ncbi.nlm.nih.gov/18606344/
  35. Green, Jody, et al. “Oral and Intravenous Acetylcysteine for Treatment of Acetaminophen Toxicity: A Systematic Review and Meta-Analysis.” Western Journal of Emergency Medicine, vol. 14, no. 3, 1 May 2013, pp. 218–226, 10.5811/westjem.2012.4.6885; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3656701/
  36. Aydin, Seval, et al. “N-Acetylcysteine Reduced the Effect of Ethanol on Antioxidant System in Rat Plasma and Brain Tissue.” The Tohoku Journal of Experimental Medicine, vol. 198, no. 2, 2002, pp. 71–77, 10.1620/tjem.198.71; https://pubmed.ncbi.nlm.nih.gov/12512991/
  37. Caro, Andres A., et al. “N-Acetylcysteine Inhibits the Upregulation of Mitochondrial Biogenesis Genes in Livers from Rats Fed Ethanol Chronically.” Alcoholism, Clinical and Experimental Research, vol. 38, no. 12, 1 Dec. 2014, p. 2896, 10.1111/acer.12576; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4293075/
  38. Ozaras, Resat, et al. “N-Acetylcysteine Attenuates Alcohol-Induced Oxidative Stress in the Rat.” World Journal of Gastroenterology, vol. 9, no. 1, 2003, p. 125, 10.3748/wjg.v9.i1.125; https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4728225/
  39. Wang, A; A dual effect of N-acetylcysteine on acute ethanol-induced liver damage in mice.; Hepatol Res. 2006 Mar;34(3):199-206; Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16439183
  40. Abenavoli, Ludovico, et al; “Milk Thistle in Liver Diseases: Past, Present, Future.”; Phytotherapy Research : PTR; U.S. National Library of Medicine; Oct. 2010; https://www.ncbi.nlm.nih.gov/pubmed/20564545
  41. Saba, P. et al; “Effetti terapeutica della silimarina nelle epatopatie croniche indotte da psicofarmaci”; Gaz Med Ital; 135:236251; 1976
  42. World Health Organization; “WHO Monographs on Selected Medicinal Plants – Volume 2”; 2004; https://apps.who.int/medicinedocs/en/d/Js4927e/29.html
  43. Palasciano G et al; “The effect of silymarin on plasma levels of malondialdehyde in patients receiving long-term treatment with psychotrophic drugs”; Current Therapeutic Research; 55:537-545; 1994; https://moh-it.pure.elsevier.com/en/publications/the-effect-of-silymarin-on-plasma-levels-of-malon-dialdehyde-in-p
  44. Di Mario FR, Melzer J, Meier R; “Die Wirkung von Silymarin auf Leberfunktionsproben bei Patienten mit alkoholbedingter Lebererkrankung”; Doppelblindstudie. In: Di Ritis F, Csomos G, Braatz R, editors. Der toxisch-metabolische Leberschaden Lübeck: Hansisches Verlagskontor; p. 54–8; 1981
  45. Hellerbrand, C., Schattenberg, J.M., Peterburs, P. et al; “The potential of silymarin for the treatment of hepatic disorders”; Clinical Phytoscience; 2, 7; 2017; https://link.springer.com/article/10.1186/s40816-016-0019-2
  46. Fehér, J et al; “Liver-protective action of silymarin therapy in chronic alcoholic liver diseases”; Orvosi Hetilap; 130(51):2723-7; December 17, 1989; https://www.ncbi.nlm.nih.gov/pubmed/2574842
  47. Ferenci, P et al; “Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver”; Journal of Hepatology; 9(1):105-13; July 1989; https://www.ncbi.nlm.nih.gov/pubmed/2671116
  48. Velussi, M, et al; “Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients”; Journal of Hepatology; 26(4):871-9; April 1997; https://www.ncbi.nlm.nih.gov/pubmed/9126802
  49. Parés, A, et al; “Effects of silymarin in alcoholic patients with cirrhosis of the liver: results of a controlled, double-blind, randomized and multicenter trial”; Journal of Hepatology; 28(4):615-21; April 1998; https://www.ncbi.nlm.nih.gov/pubmed/9566830
  50. Shawn M. Talbott, Kerry Hughes; “The Health Professional’s Guide to Dietary Supplements”; Lippincott Williams & Wilkins; 2007; https://books.google.com/books?id=hV2_TdmoDo8C
  51. Schuppan D, Strösser W, Burkard G, et al; “Legalon lessens fibrosing activity in patients with chronic liver diseases” [in German]. Z Allgemeinmed; 74:577–84; 1998
  52. Albrecht M, Frerick H, Kuhn U, et al; “Therapy of toxic liver pathologies with Legalon” [in German]; Z Klin Med; 47:87-92; 1992
  53. Szilárd S, et al; “Protective effect of Legalon in workers exposed to organic solvents”; Acta Medica Hungarica; 45(2):249-56; 1998; https://www.ncbi.nlm.nih.gov/pubmed/3073356
  54. Polachi, Navaneethakrishnan, et al; “Modulatory Effects of Silibinin in Various Cell Signaling Pathways against Liver Disorders and Cancer – A Comprehensive Review.”; European Journal of Medicinal Chemistry; U.S. National Library of Medicine; 10 Nov. 2016; https://www.ncbi.nlm.nih.gov/pubmed/27517806
  55. de Avelar, Camila Ribeiro et al; “Effect of silymarin on biochemical indicators in patients with liver disease: Systematic review with meta-analysis.”; World journal of gastroenterology; vol. 23,27; 2017; 5004-5017; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526770/
  56. Winterbourn, C. C., and D. Metodiewa. “The Reaction of Superoxide with Reduced Glutathione.” Archives of Biochemistry and Biophysics, vol. 314, no. 2, 1 Nov. 1994, pp. 284–290, 10.1006/abbi.1994.1444; https://pubmed.ncbi.nlm.nih.gov/7979367/
  57. Cardey, Bruno, et al. “Mechanism of Thiol Oxidation by the Superoxide Radical.” The Journal of Physical Chemistry A, vol. 111, no. 50, Dec. 2007, pp. 13046–13052, 10.1021/jp0731102; https://pubmed.ncbi.nlm.nih.gov/18044848/
  58. Witschi, A., et al. “The Systemic Availability of Oral Glutathione.” European Journal of Clinical Pharmacology, vol. 43, no. 6, 1992, pp. 667–669, 10.1007/BF02284971; https://pubmed.ncbi.nlm.nih.gov/1362956/
  59. Bertaccini, Alessandro, et al. “Observational Database Serenoa Repens (DOSSER): Overview, Analysis and Results. A Multicentric SIUrO (Italian Society of Oncological Urology) Project.” Archivio Italiano Di Urologia, Andrologia: Organo Ufficiale [Di] Societa Italiana Di Ecografia Urologica E Nefrologica, vol. 84, no. 3, 1 Sept. 2012, pp. 117–122; https://pubmed.ncbi.nlm.nih.gov/23210402/
  60. Wilt TJ, et al.; “Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review.”; [published correction appears in JAMA 1999 Feb 10;281(6):515]. JAMA. 1998;280(18):1604‐1609. doi:10.1001/jama.280.18.1604; https://pubmed.ncbi.nlm.nih.gov/9820264/
  61. Koh, Jong-Ho, et al. “Antifatigue and Antistress Effect of the Hot-Water Fraction from Mycelia of Cordyceps Sinensis.” Biological & Pharmaceutical Bulletin, vol. 26, no. 5, 1 May 2003, pp. 691–694, 10.1248/bpb.26.691; https://pubmed.ncbi.nlm.nih.gov/12736514/
  62. Zhao-Long, W., et al. “Inhibitory Effect of Cordyceps Sinensis and Cordyceps Militaris on Human Glomerular Mesangial Cell Proliferation Induced by Native LDL.” Cell Biochemistry and Function, vol. 18, no. 2, 1 June 2000, pp. 93–97; https://pubmed.ncbi.nlm.nih.gov/10814966/
  63. Li, Y., et al. “Clinical Application of Cordyceps Sinensis on Immunosuppressive Therapy in Renal Transplantation.” Transplantation Proceedings, vol. 41, no. 5, June 2009, pp. 1565–1569, 10.1016/j.transproceed.2009.02.085; https://pubmed.ncbi.nlm.nih.gov/19545680/
  64. Dreno, Brigitte, et al. “Acne: Evolution of the Clinical Practice and Therapeutic Management of Acne between 1996 and 2000.” European Journal of Dermatology: EJD, vol. 13, no. 2, 1 Mar. 2003, pp. 166–170; https://pubmed.ncbi.nlm.nih.gov/12695133/
  65. Sharquie, Khalifa E., et al. “Topical Zinc Sulphate Solution for Treatment of Viral Warts.” Saudi Medical Journal, vol. 28, no. 9, 1 Sept. 2007, pp. 1418–1421; https://pubmed.ncbi.nlm.nih.gov/17768472/
  66. Crutchfield, C. E., et al. “The Highly Effective Use of Topical Zinc Pyrithione in the Treatment of Psoriasis: A Case Report.” Dermatology Online Journal, vol. 3, no. 1, 1 Mar. 1997, p. 3; https://pubmed.ncbi.nlm.nih.gov/9141364/
  67. Gandia, P. et al; “A bioavailability study comparing two oral formulations containing zinc (Zn bis-glycinate vs. Zn gluconate) after a single administration to twelve healthy female volunteers”; Int J Vitam Nutr Res. 2007 Jul;77(4):243-8; https://pubmed.ncbi.nlm.nih.gov/18271278
  68. DiSilvestro, Robert A., et al. “Moderately High Dose Zinc Gluconate or Zinc Glycinate: Effects on Plasma Zinc and Erythrocyte Superoxide Dismutase Activities in Young Adult Women.” Biological Trace Element Research, vol. 168, no. 1, 1 Nov. 2015, pp. 11–14, 10.1007/s12011-015-0334-3; https://pubmed.ncbi.nlm.nih.gov/25877802/
  69. Schlegel, P., and W. Windisch. “Bioavailability of Zinc Glycinate in Comparison with Zinc Sulphate in the Presence of Dietary Phytate in an Animal Model with 65Zn Labelled Rats.” Journal of Animal Physiology and Animal Nutrition, vol. 90, no. 5-6, June 2006, pp. 216–222, 10.1111/j.1439-0396.2005.00583.x; https://pubmed.ncbi.nlm.nih.gov/16684142/
  70. Sahib, A, et al; “Effects of Oral Antioxidants on Lesion Counts Associated with Oxidative Stress and Inflammation in Patients with Papulopustular Acne”; Journal of Clinical & Experimental Dermatology Research 3(5):163; January 2012; 10.4172/2155-9554.1000163; https://www.researchgate.net/publication/264715686_Effects_of_Oral_Antioxidants_on_Lesion_Counts_Associated_with_Oxidative_Stress_and_Inflammation_in_Patients_with_Papulopustular_Acne

Comments and Discussion (Powered by the PricePlow Forum)