A while back, we introduced you to Primeval Labs, a “hardcore” brand well-known to the anabolics / prohormone crowd, but not widely known outside those circles. On our main Primeval page, we mention that they were about to release more mainstream products throughout 2017, appealing to a more diverse audience outside of the hardcore crowd.
Today, we’re back with that all new Gray Matter, an incredibly well dosed nootropic supplement for cognitive focus that will bring some serious brain gains your way.
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Gray Matter Ingredients
Gray Matter touts a solid combination of ingredients and doses, unlike so many other nootropic formulas today which are horribly underdosed. Best of all, it’s only a two-capsule dose — many focus boosters require three or four caps and run more expensive.
Primeval’s brain booster here should give plenty of focus all backed by the strong dose of caffeine, meaning in addition to greater cognition, you’ll also have improved mood and energy to boot!
Note: Doses listed below are based on one serving (i.e. 2 capsules).
Gray Matter starts of its brain-boosting formula with L-Tyrosine, an amino acid commonly seen in many nootropic formulas. Research demonstrates that Tyrosine enhances mental focus by increasing the production of noradrenaline and dopamine, two vitally important neurotransmitters.[1,2] On top of that, tyrosine also supports healthy mood and reduces stress.[3,4]
Alpha GPC (250mg)
Next up, we have one of the premier forms of choline in Alpha GPC. Of the various forms of choline available, research documents this particular form to be the most effective and bioavailable form of choline for the body. Clinical trials using Alpha GPC note increased focus and mood, as well as significantly greater “mind-muscle connection.”
Furthermore, Alpha GPC has been found to increase power output and endurance and even post-workout Growth Hormone (GH) level![5,6,7] 250mg is a great dose, and if you’re taking Gray Matter twice a day (as the directions indicate), you should definitely feel the ongoing effects of this ingredient at 500mg/day!
For even more info on Alpha GPC in terms of training, see where we discuss higher doses of Alpha GPC increasing strength — so there are other benefits of this ingredient that aren’t strictly related to mental matters.
Primarily found in tea leaves, Theanine is an amino acid found frequently used for its relaxing qualities — though that’s not why it’s included here.
In fact, when paired with caffeine (our next ingredient), theanine greatly enhances the cognitive focus effects of caffeine, and helps reduce stress, anxiety and fatigue.[9,10]
Additionally, pairing theanine with caffeine helps “smooth out” the harsh kick higher doses of caffeine sometimes carry. You don’t often see this high of a dose because it is an expensive ingredient.
Is this too much though?
For some people, having a large dose of Theanine makes them feel too relaxed and not really zoned in. It will be interesting to see how this high dose of Theanine works alongside the slower-absorbing dose of caffeine in Gray Matter. The dose of L-theanine here will really the make-or-break this product for most users, but the research does show great focus when paired with caffeine.
Infinergy® Dicaffeine Malate (250mg)
For some extra energy and focus, Primeval includes a powerful 250mg dose of Infinergy dicaffeine malate. Infinergy contains 73% caffeine, which means that each serving of Gray Matter contains 182.5mg caffeine per serving.
Infinergy provides a nice smooth, sustained release of caffeine which means you shouldn’t ever feel “amped” up just a pleasant increase in energy and greater alertness.
Yet, with 182.5mg caffeine, which will work slower, whether or not you want this is going to come down to the theanine:caffeine ratio. You have a bit more theanine here, and this is a personal thing that you should discover where your sweet spot is. Theanine lovers who don’t want a crazy amount of caffeine are definitely going to be happy here!
Get ready for the heavy hitter in Gray Matter folks, Noopept is on the scene! Also known as N-phenylacetyl-L-prolylglycine, Noopept is a proline-containing dipeptide, and one hell of a nootropic powerhouse.
Noopept has been noted in research to sensitize acetylcholine receptors to amplify its function, as well as bind to NMDA glutamatergic receptors which assists with something known as “‘long term potentiation” (LTP).
LTP is responsible for creating stable, long-lasting memories in the brain. It’s one of the reasons some memories much longer than others.
For more information on this incredible nootropic, read our guide titled Noopept: Enhancing the Smart Within.
Vinpocetine doesn’t get as much traction with the masses as many of the other nootropics we’ve discussed, but it still pretty powerful in its own right. Vinpocetine enhances brain function and cognition via increasing vasodilation and blood flow to the brain. This ultimately amplifies short term memory and overall cognitive function.
Huperzine A (100mcg)
Our last nootropic is the choline extender, Huperzine A. As opposed to Alpha GPC, which directly increases acetylcholine production in the body, Huperzine operates a bit differently.
Rather than increase increase production, Huperzine helps choline “survive” longer in the body by inhibiting acetylcholinesterase, the enzyme responsible for acetylcholine breakdown. Therefore, Huperzine can be though of as an indirect booster of acetylcholine.
Also, Huperzine protects against the “neuron death molecule” glutamine, and may even help create new brain cells, a process known as “neurogeneration.”
This is a pretty significant dose of Huperzine, especially when you consider that you’ll be consuming 200mcg per day if using the full daily dose!
Consume 2 capsules once in the morning, and another 2 capsules in the evening. We of course wouldn’t recommend those evening capsules too late at night because the Dicaffeine Malate will definitely last a while.
Primeval Labs has kept insanely busy, with the addition of their awesome new Militant Supplements Shell Shock pre workout that we featured, fronted by @that1legmonster, KC Mitchell. We can’t get over how good the BIOS3 IntraCell 7 intra workout is either (our review here)! Great stuff coming from this brand.
Meanwhile, there’s definitely been an increase in the number of brain-boosting supplements across the industry. So much so, that we’re thinking 2017 might be the “Year of the Nootropic.” Stims can only take you so far when dealing with work, studying, or exercise. Nootropics represent another venue where you can get a leg up on the competition by simply being more in the zone from a mental standpoint.
The body follows where the mind goes, so to speak.
Gray Matter is a full spectrum nootropic supplement that will have you locked in, no matter the task at hand.
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- Deijen, J; Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course.; Department of Clinical Neuropsychology, Vrije Universiteit; 1999
- Neri, D; The effects of tyrosine on cognitive performance during extended wakefulness.; Naval Aerospace Medical Research Laboratory; 1995
- Deijen JB, Orlebeke JF; Effect of tyrosine on cognitive function and blood pressure under stress . Brain Res Bull. (1994)
- Dollins AB, et al; L-tyrosine ameliorates some effects of lower body negative pressure stress . Physiol Behav. (1995)
- Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise.
- Alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.
- Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.
- Giesbrecht, Timo, et al; “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness”; Nutritional Neuroscience; 2010
- Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. (2007)
- Owen GN, et al. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. (2008)
- Ostrovskaya et al. (2007). The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model.Journal of psychopharmacology, 21(66): 611-619; Doi: 10.1177/0269881106071335; Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17092975
- Martinez, J., & Derrick, B. (1996). Long term Potentiation and Learning. Annual Review of Psychology, 47(1): 173-203. Retrieved from http://www.annualreviews.org/doi/abs/10.1146/annurev.psych.47.1.173
- Doxiderol; “Vinpocetine;” Retrieved February 2014
- Zhao, Q; Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2002
- Ved, H; Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate.; Division of Biochemistry, Walter Reed Army Institute of Research; 1997
- Ma, T; Huperzine A promotes hippocampal neurogenesis in vitro and in vivo.; State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua University; 2013