One of the hottest nootropics we covered at the beginning of this year was AZOTH, a fully loaded nootropic supplement that increases motivation, focus, memory recall, and mental like you’ve probably never experienced before.
AZOTH is still relatively young, but has already been revamped to remove some of the more questionable ingredients and add in some other nootropics that make this a must try product if you’re into nootropics. Unfortunately, it still isn’t in any of our stores yet, but you can grab some for yourself by heading to SeekingAZOTH.com.
Note:Free shipping will last until the end of the month.
Note: We’re not receiving commissions for these coupon codes. Maybe we should though, because this one’s gonna sell once you see this label!
Delving Into the Design of AZOTH
We’re always curious about the origins of how a formula comes to life, and sometimes we’re fortunate enough to get an insider’s look into the design process from the gurus themselves. The guys behind AZOTH have developed quite a monster nootropic in their first supplement (as you’ll soon see!). Here’s a bit on the design of the formula from the designers themselves:
“The market is flooded with supplements that make you feel great for a few hours but leave you with a bad crash. That might be just fine for someone who is only looking to kill it in the gym for an hour or two, but for the go-getter who needs to perform at peak levels throughout the day? Forget it. So what we’re seeing now is that instead of relying on caffeinated products and stimulants, many high-performers are abandoning them altogether, afraid that the resulting side-effects will actually hinder their performance when the crash hits later in the day. Instead of solving this problem, most supplement companies are just adding more stimulants, which is only making the problem worse, forgetting that a vast majority of their consumers are everyday people who are using their product for purposes inside but also outside of the gym.
Here’s where AZOTH differs. Instead of just adding a bunch of new exotic nootropics and stimulants, we did something different: we used tried and true energy and focus boosting ingredients like Sulbutiamine and patented TeaCrine®, and we infused it with a synergy of cortisol blockers and adaptogens so that any rises in energy would immediately be countered by blocking increases in cortisol and ensuring that the user would not be left with a nasty crash. Furthermore, when the formula wears off, it does so gradually and ensures that the user’s energy levels remained constant throughout the day. The result? Focus, Energy, and no adrenal fatigue, tolerance build-up, or crash. In a nutshell, AZOTH V2 is every high-performer’s best friend and what we’d call a second-generation energy nootropic formula.”
AZOTH is one of the most unique nootropic products we’ve seen as it’s completely caffeine free, but does contain some proven energy and alertness boosters like TeaCrine and Sulbutiamine!
You’ll notice there’s quite a bit of difference between the V1 AZOTH and the new V2 edition described here.
Note: Doses listed below are based on 1 serving (i.e. 3 capsules)
Ashwagandha Extract (500mg)
Occasionally referred to as “Smell of Horse”, Ashwagandha is an incredibly popular Ayurvedic herb that’s similar to Rhodiola. Ashwagandha is a powerful adaptogen that helps combat feelings of anxiety and stress. It’s also been shown to lower cortisol levels in the body.
Aside from its stress-relieving qualities, Ashwagandha also is a pretty effective nootropic that enhances cognitive and psychomotor performance. Specifically, ashwagandha has been shown to improve reaction time and mental arithmetic ability.[26,27]
One of the first major changes to AZOTH is the swap from N-Acetyl L-Tyrosine to the much more effective L-Tyrosine. We’ve discussed L-Tyrosine vs. N-Acetyl L-Tyrosine in great length on this blog, so we won’t go into detail about it here except to say we’re happy to see this switch.
L-Tyrosine increases noradrenaline and dopamine production which in turn reduces stress and anxiety, yet elevates focus and cognition.[3,4]
The dose here is a bit on the lower end for what we’d like to see with L-Tyrosine, but given the truckload of noots still to come, we don’t see this being much of an issue.
Phosphatidylserine (PS) marks the first “new” addition to AZOTH (we’re not counting L-Tyrosine, as N-Acetyl L-Tyrosine was in V1). For those of you not familiar with PS, it’s a fat-soluble amino acid found mostly in the brain that enhances cognitive function.
Research notes that PS can treat symptoms associated with depression and declining mental function in the elderly.[5,6] Additionally, Phosphatidylserine exerts anti-anxiety and stress-reducing properties; plus, it also has been shown to reduce cortisol levels when dosed high enough, as it is here.[7,8]
This is a serious dose, and would be felt on its own even without all of the other ingredients! Phosphatidylserine prices have come down, and the nootropic community has received far better supplements because of that.
We recently covered sulbutiamine rather extensively in our mega-post titled: Sulbutiamine: The Brain-Boosting B Vitamin, so head there if you want all the details, but to briefly go over this ingredient’s functions…
Sulbutiamine is a synthetic form of the B vitamin Thiamin (Vitamin B1) that can cross the blood-brain barrier, effectively increasing levels of thiamine in the body. The really cool thing about sulbutiamine those are its nootropic benefits which include increased alertness, memory, focus, and wakefulness.[9,10,11]
The dose here is great as sulbutiamine is commonly dosed between 400-600mg, this alone makes AZOTH worth checking out if you’ve been looking for a comprehensive nootropic formula that includes this ingredient.
Alpha GPC (300mg)
Alpha GPC is a choline-containing compound that increases the production of acetylcholine, a.k.a. the “learning neurotransmitter.” Clinical studies using Alpha GPC documented it enhances power output, endurance, and post workout Growth Hormone (GH) levels.[13,14,15]
Alpha GPC is one of our favorites forms of choline (along with CDP Choline). It’s one of the best in terms of bioavailability and quality, and certainly a proven focus-booster.
TeaCrine is starting to show up more and more in nootropic formulas due to its smooth, long-lasting energy, and the fact that it doesn’t come with the tolerance build up of caffeine. This CNS stimulant also reduces oxidative stress and increases dopamine levels, similar to the way caffeine does in the brain.[17,18]
Take Azoth with a cup of coffee or your favorite energy drink and watch how much longer things last because of the TeaCrine inside!
Up next, is the well known beta-2 receptor agonist Hordenine. This stimulant functions as a strong bronchodilator (relaxes bronchial passages) and vasodilator.
More pertinent to the benefits of AZOTH, Hordenine acts as a noradrenaline reuptake modulator[20,21] — meaning it helps helps noradrenaline stay active longer in your body conveying stronger focus, alertness, and energy.
Huperzine A (100mcg)
Our final nootropic is the great acetylcholine-extender, Huperzine A, a.k.a Toothed Club Moss. Huperzine A inhibits acetylcholinesterase, the enzyme used to break down acetylcholine, thereby indirectly boosting acetylcholine levels — as opposed to Alpha GPC which directly increases acetylcholine levels..
Huperzine also defends against glutamate, a.k.a. “the neuron death molecule” and it may even help generate new brain cells (making it neurogenerative).
Lastly, we have the absorption enhancer BioPerine®. This patented black pepper extract is widely used for improving the bioavailability of the other compounds included in AZOTH ensuring your body and brain make the most of the brain-boosting compounds contained herein.
Regarding the updated formula
”One of the drawbacks of the previous formula was that it could not be dosed frequently due to the tolerance build-up and furthermore, the cost was on the higher end. When the news came that Phenylpiracetam and Noopept would undergo regulatory scrutiny, we decided we could do something better. With this formula, there is neither an issue of tolerance build-up and the cost is significantly lower. So while many have asked whether this is a downgrade, we’re actually happier with this newer formula because it’s a win-win.”
For optimal results, use 1-2 capsules of AZÖTH with a light meal containing healthy fats every other day. The ingredients in AZÖTH will pronounce and prolong any stimulants you are consuming, so use other stimulant sources with caution while consuming AZÖTH. Under no circumstances should you exceed 3 capsules in one day.
A Note on Stacking:
Many people (like Robert) love super-strong focus during the workouts, and will often add in some bulk nootropics to energy or pump-based pre workouts. So this got us to wondering how AZOTH would stack with a pre workout and so we reached out to the formulators who responded with the following:
”The great thing about AZÖTH is that you can take it in conjunction with a pre-workout or other sports supplements, as a matter of fact, it will only amplify the effects of any other supplements you are taking.”
So if you like your energy drinks or coffee, you can keep your energy drinks or coffee!
How about that for a serious formula upgrade?!
AZOTH packs all you’d need and then adds even more to give you superior focus unlike you’ve probably ever experienced before. You’ll get more work done, in a more efficient manner, and been in one heck of a good mood while you’re doing it.
AZOTH is NOT cheap, but luckily we’ve got a coupon code you can use, should you be looking to step up your nootropics game to the big league:
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- Kulkarni SK, Dhir A; “Withania somnifera: an Indian ginseng”; Prog Neuropsychopharmacol Biol Psychiatry; 2008; http://www.ncbi.nlm.nih.gov/pubmed/17959291
- Bhutani, K; “Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology”; Journal of Ethnopharmacology; http://www.ncbi.nlm.nih.gov/pubmed/15261983
- Deijen JB, Orlebeke JF; Effect of tyrosine on cognitive function and blood pressure under stress . Brain Res Bull. (1994)
- Dollins AB, et al; L-tyrosine ameliorates some effects of lower body negative pressure stress . Physiol Behav. (1995)
- YU Langone Medical Center; “Phosphatidylserine;” Updated August 2013
- Kataoka-Kato A., et al.; Journal of Pharmacological Sciences; “Enhanced learning of normal adult rodents by repeated oral administration of soybean transphosphatidylated phosphatidylserine;” July 2005
- Gindin J., et al.; The Geriatric Institute for Education and Research, Kaplan Hospital, Rehovot, Israel; “THE EFFECT OF PLANT PHOSPHATIDYLSERINE ON AGE-ASSOCIATED MEMORY IMPAIRMENT AND MOOD IN THE FUNCTIONING ELDERLY;” 1993
- Micheau J, Durkin TP, Destrade C, Rolland Y, Jaffard R. Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacol Biochem Behav. 1985;23(2):195-198. https://www.ncbi.nlm.nih.gov/pubmed/4059305
- Bettendorff L, Weekers L, Wins P, Schoffeniels E. Injection of sulbutiamine induces an increase in thiamine triphosphate in rat tissues. Biochem Pharmacol. 1990;40(11):2557-2560. https://www.ncbi.nlm.nih.gov/pubmed/2268373
- Bizot J-C, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(6):928-935. doi:10.1016/j.pnpbp.2005.04.035. https://www.ncbi.nlm.nih.gov/pubmed/15951087
- Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise.
- Alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.
- Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.
- Cauli, O;Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release.; Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari; 2008
- Li WX, et al.; “Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.“; J Agric Food Chem.; 2013
- Feduccia A, et al.; “Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.”; Pharmacol Biochem Behav; 2012
- Frank M, et al; Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse; Equine Vet J. (1990)
- Barwell C.; School of Pharmacy; “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat;” 1989
- Nedergaard O.; British Journal of Pharmacology; “Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig;” November 1968
- McDaniel MA., et al.; Nutrition; “Brain-specific” nutrients: a memory cure?”; November-December 2003; http://www.ncbi.nlm.nih.gov/pubmed/14624946
- McDaniel MA., et al.; Nutrition; “Brain-specific” nutrients: a memory cure?”; November-December 2003; http://www.ncbi.nlm.nih.gov/pubmed/14624946
- Zhao, Q; “Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine”; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2002; http://www.ncbi.nlm.nih.gov/pubmed/12445575
- Ved, H; “Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate”; Division of Biochemistry, Walter Reed Army Institute of Research; 1997; http://www.ncbi.nlm.nih.gov/pubmed/9141073
- Pingali U, Pilli R, Fatima N. Effect of standardized aqueous extract of Withania somnifera on tests of cognitive and psychomotor performance in healthy human participants. Pharmacognosy Res. 2014;6(1):12-18.
- Karnick CR. A double-blind, placebo-controlled clinical studies on the effects of Withania somnifera and Panax Ginseng extracts on psychomotor performance in healthy Indian volunteers. Indian Med. 1991;3:1–5.
Our AZOTH V1 Review
Mike and CJ took to the original formula of AZOTH before starting a technical project, and while it’s pricey (the coupons above definitely help), the stuff has been incredible — especially given that it’s caffeine-free!