AZOTH – Holy Fully Loaded Nootropic!!

Seeking Azoth

Are you Seeking Azoth? After reading this write-up, you might want to…

At the end of last year, we forecasted that 2017 would be the “Year of the Nootropic” as they seemed to be catching on a bit at the end of 2016 and were set to explode in the new year. Well, the new year is here, and we’ve got one hell of an opener for the onslaught of nootropic-based products to come this year!

AZOTH is a fully loaded nootropic supplement that will increase motivation, memory recall, and stamina; plus give you tunnel vision like you’ve probably never experienced before.

AZOTH is brand new on the scene and isn’t in any of our stores yet, but you can grab some for yourself by heading to SeekingAZOTH.com.

The cool thing is that AZOTH has created special coupon codes, just for readers at PricePlow:

  • PLOW40 → 40%OFF ​(Applies if you want to buy 1. If you buy more than 1, the next is better)
  • PLOW50FOR1 → ​Buy one, get one free. (Applies to 3, 4, or more packs as well).
AZOTH

AZOTH is a fully-loaded nootropic supplement developed to increase your motivation, focus, energy, and productivity.

Note: We’re not receiving commissions for these coupon codes. Maybe we should though, because this one’s gonna sell once you see this label!

Our AZOTH Review

Mike and CJ took to AZOTH before starting a technical project, and while it’s pricey (the coupons above definitely help), the stuff has been incredible — especially given that it’s caffeine-free!

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Delving Into the Design of AZOTH

We’re always curious about the origins of how a formula comes to life, and sometimes we’re fortunate enough to get an insider’s look into the design process from the gurus themselves. The guys behind AZOTH have developed quite a monster nootropic in their first supplement (as you’ll soon see!). Here’s a bit on the design of the formula from the designers themselves:

“AZÖTH stands in a category of its own, which we call HPO (Human Potential Optimizer). The ingredients work in synergy to amplify latent energy, raw motivation, and mental prowess to superhuman levels. This is NOT your run of the mill pre-workout.

While Nootropics or “smart drugs” are all the rage in the business world, never before has a company tried to introduce this class of potent ingredients to the strength and fitness community, which is ironic because nootropics were created by the Soviet bloc countries for their athletes in the first place.

By combining high doses of pharmaceutical-grade cognitive enhancers with potent strength ingredients such as NALT and Octodrine ​ (DMHA), AZÖTH is effectively treading into uncharted waters, pioneering the way for a new class of sports supplements and equipping the general public with ingredients that have been kept secret from them since the Cold War. ​ ”

AZOTH Ingredients

AZOTH is one of the most unique nootropic products we’ve seen as it’s completely caffeine free, but does contain some of the more exotic ingredients out there such as DMHA, Phenylpiracetam, and Noopept.

Note: Doses listed below are based on 1 serving (i.e. 3 capsules)

  • N-Acetyl L-Tyrosine (350mg)

    AZOTH Ingredients

    AZOTH touts a jam-packed ingredient list headlined by a whopping 50mg of noopept in a full serving! LOOK OUT!

    N-Acetyl L-Tyrosine (NALT) is a more soluble, and expensive, form of the popular focus-boster, L-Tyrosine. NALT increases noradrenaline and dopamine production which in turn reduces stress and anxiety, yet elevates focus and cognition.[1,2]

    The dose here is a bit on the lower end for what we’ve been seeing recently with NALT, but given the truckload of noots still to come, we don’t see this being much of an issue.

  • Alpha GPC (300mg)

    Alpha GPC is a choline-containing compound that increases the production of  acetylcholine, a.k.a. the “learning neurotransmitter.”[3] Clinical studies using Alpha GPC documented it enhances power output, endurance, and post workout Growth Hormone (GH) levels.[4,5,6]

    Alpha GPC is one of our favorites forms of choline (along with CDP Choline). It’s one of the best in terms of bioavailability and quality, and certainly a proven focus-booster.

  • Ashwagandha Root (300mg)

    Ashwagandha significantly reduces cortisol

    Ashwagandha is an adaptogenic herb that helps lower cortisol in addition to improving VO2 Max.

    Occasionally referred to as “Smell of Horse”, Ashwagandha is an incredibly popular Ayurvedic herb that’s similar to Rhodiola. Ashwagandha is a powerful adaptogen that helps combat feelings of anxiety and stress.[7] It’s also been shown to lower cortisol levels in the body.[8]

    As you probably know, cortisol is a particularly nasty hormone that not only wreaks havoc on your psychological state, but can also adversely impact muscle gains and encourage fat storage….neither of which are good!

  • Phenylpiracetam (150mg)

    Here’s the first “next level” ingredient in AZOTH, and one that caused our ears to perk up a bit. Phenylpiracetam is a powerful nootropic similar in nature to piracetam, another member of the racetam family.[9]

    The primary difference between piracetam and phenylpiracetam is that phenylpiracetam has the added phenyl group, which gives it a bit of mood-elevating ability of phenylethylamine (PEA). Additionally, studies using low doses of phenylpiracetam have found that it:

    • Increases CNS stimulation[9]
    • Improves memory uptake, storage and recall[10]
    • Enhances motivation, attention and desire[11]

    You can read more on our blog post aptly titled Phenylpiracetam: The Limitless Nootropic.

  • DMHA (100mg)

    DMHA

    DMHA: A new workout/focus stimulant that’s roughly ~90% the strength of DMAA, has animal research, and seems to be compliant? Healthy and experienced stimulant users read on!

    Shifting gears from pure nootropics to stimulants, brings us to the breakout stim of 2016, DMHA. Also known as Octodrine, DMHA is an aliphatic amine (similar to DMAA), found in the Kigelia Africana fruit.[12] You’ll also see DMHA labeled as a couple other names including 2-amino-6-methylheptane and the extremely vague “2-aminoisoheptane”.

    DMHA increases dopamine and norepinephrine levels in the brain[13,14] leading to significantly improved alertness, mood, and energy without feeling overly stimmed.[15]

  • Hordenine (100mg)

    Up next, is the well known beta-2 receptor agonist Hordenine. This stimulant functions as a strong bronchodilator (relaxes bronchial passages) and vasodilator.[16]

    More pertinent to the benefits of AZOTH, Hordenine acts as a noradrenaline reuptake modulator[17,18] — meaning it helps helps noradrenaline stay active longer in your body conveying stronger focus, alertness, and energy.

  • Noopept (50mg)

    Noopept vs. Piracetam

    Noopept is one of the most potent nootropics you can use, just make sure to pair it with a source of choline to avoid brain fog.

    HOLY DOSAGE BATMAN!

    We’ve covered Noopept in great detail before in our Noopept Mega Guide: Enhancing the Smart Within, but never seen it used in a supplement at this dosage! WOW!

    Noopept, also known as N-phenylacetyl-L-prolylglycine, is a proline-containing dipeptide that is an analogue originally created as an analog to another well known nootropic, piracetam.[19]

    Noopept is an amazingly powerful and effective nootropic that’s been shown to improve memory and learning[20,21], increase acetylcholine production[19], and reduce anxiety.[22]

    There is one area of concern with noopept though, especially at this dose! Noopept can often lead to headaches due to choline-depletion. To counteract this, AZOTH includes 300mg of Alpha GPC which we detailed above.

    Still though, it may be best to start with 1-2 capsules of AZOTH initially and see how you fare.

    The formulators behind AZOTH also had a bit to add in when we asked why the dosage was so high:

    ”While the Noopept dose is high, it’s important to note that Noopept only has a 10%- 20% bioavailability when taken orally. This is why most of the reports of Noopept we hear or read about at smaller doses are administered nasally or sublingually.”

  • Vinpocetine (15mg)

    Found in Periwinkle, vinpocetine is an alkaloid compound generally considered a nootropic for its positive impact on both short and long-term memory. Vinpocetine’s cognitive-enhancing abilities have been attributed to its capability to improve blood flow to the brain[23,24,25], which earned it the nickname of “Viagra for the brain.”[26]

    Increased blood flow also delivers more nutrients and oxygen to the brain which elevates focus, awareness, and reaction speed.[27]

  • Huperzine 1% (10mg)

    Acetylcholinesterase

    Acetylcholinesterase breaks down our acetylcholine. Huperzine A helps slow this process down.

    Our final nootropic is the great acetylcholine-extender, Huperzine A, a.k.a Toothed Club Moss. Huperzine A inhibits acetylcholinesterase, the enzyme used to break down acetylcholine, thereby indirectly boosting acetylcholine levels[28] — as opposed to Alpha GPC which directly increases acetylcholine levels..

    Huperzine also defends against glutamine[29], a.k.a. “the neuron death molecule” and it may even help generate new brain cells (making it neurogenerative).[30]

  • BioPerine® (5mg)

    Lastly, we have the absorption enhancer BioPerine®. This patented black pepper extract is widely used for improving the bioavailability of the other compounds included in AZOTH ensuring your body and brain make the most of the brain-boosting compounds contained herein.

Dosing

For optimal results, use 1-2 capsules of AZÖTH with a light meal containing healthy fats every other day. The ingredients in AZÖTH will pronounce and prolong any stimulants you are consuming, so use other stimulant sources with caution while consuming AZÖTH. Under no circumstances should you exceed 3 capsules in one day.

”It’s frustrating to see hardcore nootropic users having to go through the trouble of scouring the internet to finding raws of ingredients and having to stack them​ themselves. With AZÖTH , we wanted to create something that is truly effective, but also take the guesswork out. We’ve purposely encapsulated our products and packaged them in a re-sealable Mylar bag that you can stick in your pocket and seal at your convenience.

Looking at the serving size, you’d think 10 servings is not enough for a month. However, these ingredients are STRONG and cannot be taken daily. We recommend building up to three capsules after two weeks of use.

AZÖTH should not be taken daily because tolerance build up is a possibility. Yes, the packs are expensive, but then again – we’ve put in 10 ingredients, perfectly dosed, no prop blends, and these are ingredients that are currently sold as prescription meds in other countries so licensing is far from cheap. And we dare you to compare us to brand names that sell nootropics that include a fraction of the dosages, and don’t include any pharmaceutical grade ingredients in their product.”

A Note on Stacking:

Many people (like Robert) love super-strong focus during the workouts, and will often add in some bulk nootropics to energy or pump-based pre workouts. So this got us to wondering how AZOTH would stack with a pre workout and so we reached out to the formulators who responded with the following:

”The great thing about AZÖTH is that you can take it in conjunction with a pre-workout or other sports supplements, as a matter of fact, it will only amplify the effects of any other supplements you are taking.”

Takeaway

Mother of God

Initial thoughts on AZOTH

How about that for an opening salvo into the world of nootropics for 2017?!

AZOTH packs all you’d need and then adds even more to give you superior focus unlike you’ve probably ever experienced before. You’ll get more work done, in a more efficient manner, and been in one heck of a good mood while you’re doing it.

The only hesitation we have is the high dose of Noopept and the price. AZOTH is NOT cheap, but luckily we’ve got a coupon code you can use, should you be looking to step up your nootropics game to the big league:

Head to SeekingAZOTH.com and score:

  • PLOW40 → 40%OFF ​(Applies if you want to buy 1. If you buy more than 1, the next is better)
  • PLOW50FOR1 → ​Buy one, get one free. (Applies to 3, 4, or more packs as well).

Note: We’re not receiving commissions for these coupon codes. Maybe we should though, because this one’s gonna sell once you see this label!

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References

  1. Deijen JB, Orlebeke JF; Effect of tyrosine on cognitive function and blood pressure under stress . Brain Res Bull. (1994)
  2. Dollins AB, et al; L-tyrosine ameliorates some effects of lower body negative pressure stress . Physiol Behav. (1995)
  3. http://www.ncbi.nlm.nih.gov/pubmed/22071706
  4. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise.
  5. Alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.
  6. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.
  7. Kulkarni SK, Dhir A; “Withania somnifera: an Indian ginseng”; Prog Neuropsychopharmacol Biol Psychiatry; 2008; http://www.ncbi.nlm.nih.gov/pubmed/17959291
  8. Bhutani, K; “Effect of Symplocos racemosa Roxb. on gonadotropin release in immature female rats and ovarian histology”; Jouranl of Ethnopharmacology; http://www.ncbi.nlm.nih.gov/pubmed/15261983
  9. Kazoka, H., Koliskina, O., Veinberg, G., & Vorona, M. (2013). Separation of piracetam derivatives on polysaccharide-based chiral stationary phase.  Journal of Chromatography, 1281. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23394745
  10. Malykh, A. (2010).Piracetam and piracetam like drugs: from basic science to novel clinical applications to CNS disorders. Drugs, 70(3). Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20166767
  11. Firstova, D., Abaimov, D., Kapitsa, I., Voronina, T., & Kovalev, G. (2011). The Effects of Scopolamine and the Nootropic Drug Phenotropil on Rat Brain Neurotransmitter Receptors during Testing of the Conditioned Passive Avoidance Task. Neurochemical Journal, 5 (2) 115-125. Retrieved from http://link.springer.com/article/10.1134%2FS1819712411020048#page-1
  12. Arkhipov A, Sirdaarta J, Matthews B, Cock I; “Metabolomic Profiling of Kigelia africana Extracts with Anti-Cancer Activity by High Resolution Tandem Mass Spectroscopy”; Pharmacognosy Communications 4(4):10-32;·October 2014; http://www98.griffith.edu.au/dspace/bitstream/handle/10072/64248/98347_1.pdf
  13. Millan, M; “The role of monoamines in the actions of established and novel antidepressant agents: a critical review”; European Journal of Pharmacology; 500(1): 371-384; 2004. Retrieved from http://www.sciencedirect.com/science/article/pii/S0014299904007472
  14. Fleckenstein, A., Volz, T., Riddle, E., Gibb, J., & Hanson, G; “New Insights into Mechanism of Action of Amphetamines”; Annual review of Pharmacology and Toxicology; 47: 681-698; 2007. Retrieved from http://www.annualreviews.org/doi/abs/10.1146/annurev.pharmtox.47.120505.105140
  15. Wise, R., & Bozarth, M; “Brain Mechanism of Drug Reward and Euphoria”; Journal of Psychiatric Medicine, 3(4): 445-460; 1985. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/2893431
  16. Frank M, et al; Hordenine: pharmacology, pharmacokinetics and behavioural effects in the horse; Equine Vet J. (1990)
  17. Barwell C.; School of Pharmacy; “Deamination of hordenine by monoamine oxidase and its action on vasa deferentia of the rat;” 1989
  18. Nedergaard O.; British Journal of Pharmacology; “Action of various sympathomimetic amines on the isolated stripped vas deferens of the guinea-pig;” November 1968
  19. Ostrovskaya et al; “The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease model; Journal of psychopharmacology, 21(66): 611-619; 2002; Retreived from http://www.ncbi.nlm.nih.gov/pubmed/17092975
  20. Martinez, J., & Derrick, B. (1996). Long term Potentiation and Learning. Annual Review of Psychology, 47(1): 173-203. Retrieved from http://www.annualreviews.org/doi/abs/10.1146/annurev.psych.47.1.173
  21. Lee, K et al. (2003). Phosphorylation of the AMPA receptor GluR1 subunity is required for the synaptic plasticity and retention of spatial memory. Cell Press, 112(5): 631-643. Retrieved from http://www.sciencedirect.com/science/article/pii/S0092867403001223
  22. Uyanaev, A., & Fisenko, V. (2006). Studies of Long-Term Noopept and Afobazol Treatment in Rats with Learned Helplessness Neurosis. Bulletin of Experimental Biology and Medicine,142(2): 167-169. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/17369939
  23. Jha MK., et al.; International Journal of Pharmaceutical Sciences and Research; “VINPOCETINE: A SMART DRUG AND A SMART NUTRIENT: A REVIEW”; October 2011; http://ijpsr.com/bft-article/vinpocetine-a-smart-drug-and-a-smart-nutrient-a-review/
  24. Valikovics A., et al.; Ideggyogyaszati szemle.; “Study of the effects of vinpocetin on cognitive functions”; March 2012; http://www.ncbi.nlm.nih.gov/pubmed/23136730
  25. Valikovics A.; Ideggyogyaszati szemle; “Investigation of the effect of vinpocetine on cerebral blood flow and cognitive functions”; July 2007; http://www.ncbi.nlm.nih.gov/pubmed/17713111
  26. Szapary L., et al.; Ideggyogyaszati Szemle; “Vinpocetin in neurological diseases”; November 2012; http://www.ncbi.nlm.nih.gov/pubmed/23289173
  27. McDaniel MA., et al.; Nutrition; “Brain-specific” nutrients: a memory cure?”; November-December 2003; http://www.ncbi.nlm.nih.gov/pubmed/14624946
  28. McDaniel MA., et al.; Nutrition; “Brain-specific” nutrients: a memory cure?”; November-December 2003; http://www.ncbi.nlm.nih.gov/pubmed/14624946
  29. Zhao, Q; “Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine”; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2002; http://www.ncbi.nlm.nih.gov/pubmed/12445575
  30. Ved, H; “Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate”; Division of Biochemistry, Walter Reed Army Institute of Research; 1997; http://www.ncbi.nlm.nih.gov/pubmed/9141073
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