Optimum Nutrition Pro Pre: A Bigtime Pre Workout from a Big Brand

Optimum Nutrition Pro Pre

Optimum Nutrition is finally getting serious about its pre workout game with the release of the clinically-dosed Pro Pre.

While the pre workout market has been over-saturated with a slew of top pre workouts, there’s been a few huge companies missing a fully-loaded, clinically-dosed pre workout. Well, one of the biggest names in the business can now consider themselves back in the hunt for best pre workout available in Optimum Nutrition.

ON recently unveiled their newest pre workout — Pro Pre — which looks to deliver the goods, in full force, to its droves of fans around the globe.

Finally, a Pre Workout Optimum Nutrition can be proud of

This has been a long time coming – the brand that’s well-known for basic products like ON 100% Whey Protein Gold Standard has struck out a couple of times on the pre workout front. ON’s Gold Standard Pre Workout was a bit too much money for being a two-scooper, and we aren’t even sure what was going on with Platinum PRE-, which tasted like hot sauce thanks to its hot pepper extract.

So is the third round the charm? Looks like it just could be!

All the details are just ahead, but first, take a moment to check the best deal and sign up for alerts from PricePlow:

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Pro Pre Ingredients

Optimum has certainly stepped up their pre workout game in Pro Pre. The product is bringing it all — pumps, energy, focus, and endurance. Unlike the Gold Standard Pre Workout, there’s no need to 2-scoop this product either, as it’s packing 300mg caffeine per scoop, a perfect amount to get anyone motivated heading into a grueling workout.

  • L-Citrulline (6g)

    Optimum Nutrition Pro Pre Ingredients

    ON Pro Pre is chock full of well-dosed ergogenics to enhance energy, performance, and pumps.

    Right out of the gate, Pro Pre comes swinging with a robust 6g dose of the powerful nitric oxide (NO) precursor, L-Citrulline. This amino acid offers superior bioavailability in the body compared to arginine, and supports improved blood flow, athletic performance, and pumps.[1,2,3]

    The trend lately in pre workouts has been moving towards 5-6g doses of pure L-Citrulline, and we for one are very happy to see Optimum following suit.

  • CarnoSyn® Beta Alanine (3.2g)

    Like most of the well-known pre workouts these days, ON Pro Pre includes the well-known endurance booster, beta alanine. BA works with histidine (another amino acid) to increase serum carnosine levels in skeletal muscle, enhancing their ability to buffer lactic acid and offset the “burn” that sets in during prolonged activity.[4]

    Beta alanine improves endurance, power, and strength, while reducing fatigue.[5,6,7] You’ll get the full 3.2g clinical dose here, which also brings with it a serious case of the tingles.

  • Caffeine Anhydrous (300mg)

    300mg of caffeine really seems to be the “sweet spot” for pre workouts these days. Most of the best pre workouts we’ve seen as of late include this dose, and it just flat out works. Given the ever-escalating need for caffeine by the masses, 150-200mg in a pre just isn’t cutting it these days for gym goers. The 300mg dose here is great for a strong burst of energy, focus, and motivation that won’t come with much jitters, and if it does, there’s plenty of caffeine.

  • KSM-66® (300mg)

    One of the more interesting facets of ON Pro Pre is its inclusion of two extremely powerful and popular adaptogens. The first of which is KSM-66, the premier form of ashwagandha extract on the market.

    While most know the herb for its stress relief and sexual function enhancing benefits, the humble plant also offers some impressive performance benefits too. Specifically, KSM-66 has been shown in various research trials to enhance cardiovascular endurance as well as strength and muscle recovery.[8,9]

    Optimum Nutrition Pro Pre Finger

    All we can say is, it’s about time ON came out with a well-dosed pre workout.

  • Rhodiola Rosea (200mg)

    Rhodiola is a well-known adaptogen that enhances the body’s ability to respond to stress, but it also offers valuable cognitive and endurance benefits. Rhodiola helps balance neurotransmitter levels in the body and has been shown to enhance endurance in exercise performance.[10,11,12]

    Oftentimes we see either ashwagandha or rhodiola, but not usually both. This could provide a very unique feel to Pro Pre here.

  • L-Theanine (200mg)

    If you’re a little put off by the somewhat high 300mg caffeine dose, here’s some help to ease the energy assault — L-Theanine. Present in tea leaves, theanine is an amino acid that reduces the “pow” factor of caffeine anhydrous and bolsters the cognitive/focus effects of the stimulant as well.[13,14]

    Theanine will take some of the “teeth” out of the energy rush, providing a smooth, controlled energy and focus feeling while training.

  • NeuroFactor™ (100mg)

    NeuroFactor Logo

    NeuroFactor is one of the newest brain-boosting nootropics on the market with some pretty intriguing research behind it.

    Developed by Futureceuticals, NeuroFactor is a patented extract the coffee bean fruit. It’s been shown in humans to increase levels of Brain-Derived Neurotrophic Factor (BDNF) by 143%![15,16]

    Why is this important?

    BDNF is a protein in the brain and nervous systems that plays a key role in neuron development and repair. It also protects against neurodegeneration[17] and supports memory, learning, alertness, energy metabolism, and mood.

  • ResVida® (75mg)

    Developed by nutraceutical manufacturer DSM[18], ResVida is an extremely high quality form of trans-resveratrol, a powerful antioxidant found in red wine. Additionally, resveratrol has been shown to improve cerebral blood flow, which can enhance mental clarity and focus.[19,20]

    The issue with resveratrol is its poor bioavailability, which gets significantly improved with our next ingredient.

  • Bioperine® (5mg)

    Optimum Nutrition Pro Pre Performance

    ON Pro Pre is formulated with maximizing your performance everyday in the gym.

    Included to enhance the absorption of all the other ingredients (like ResVida) in Pro Pre, which is good, because there are A LOT of actives going on in here folks.

  • L-Leucine (2g)

    The “king” of amino acids and leader of the BCAAs, leucine makes an appearance in Pro Pre at a somewhat questionable 2g dose. Is it included here to stimulate mTor? Enhance muscular energy? Make keto dieters happy?

    We’re not really sure to be honest as the 2g dose really isn’t enough to stimulate mTOR (2.5-3g is needed for that, at minimum),[21,22] but there’s really never a complaint with leucine. As a ketogenic amino acid, it doesn’t spike blood sugar like the other glucogenic amino acids, so low-carb and keto-dieters will be especially happy. So despite the short dose, we’ll take it anytime, anywhere.

  • N-Acetyl L-Tyrosine (1g)

    N-Acetyl L-Tyrosine Plasma Increases

    As you can see here, in a study comparing Tyrosine (squares) and N-Acetyl L-Tyrosine (circles), NALT is inferior to other forms of tyrosine.

    For added focus, ON opts for the less effective, yet more water-soluble form of tyrosine in N-Acetyl L-Tyrosine (NALT). As we’ve stated before, we’re more in favor of L-Tyrosine since it’s been shown to be superior for increasing levels of tyrosine in the body, and thus enhancing neurotransmitter production.[23,24,25,26]

    Still the 1g dose here is commendable and should help boost focus a good bit, in addition to reducing stress.[27]

Flavors Available

Optimum is launching Pro Pre with three flavors that are considered extremely safe, and in all likelihood, have the broadest appeal.

  • Fruit Fusion
  • Grape Candy
  • Strawberry Burst

If the product is successful, we’ll probably eventually see more flavors, so sign up for alerts on this one below and we’ll notify you when we find better deals and newer flavors.

ON brings a unique feel-good pre workout

Optimum Nutrition Pro Pre Glance

Here’s what you can expect from every scoop of the new ON Pro Pre. Compare prices on all Optimum Nutrition supplements with PricePlow!

All we can say is… it’s about time these globally known companies started stepping up their pre workout game to match that of the small and medium-sized brands that have been dominating the pre workout landscape the past few years. Dymatize Pre W.O. was a fantastic release from a major competitor, so it was time for Optimum to respond in kind.

ON Pro Pre is a well-rounded formula that should land well with the masses, but as with everything, it boils down to how well it’s marketed and priced. We’re interested in the combination of Ashwagandha, Rhodiola, and NeuroFactor. This one should feel pretty special.

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References

  1. Giannesini B, et al. Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle. Eur J Pharmacol. (2011)
  2. Bendahan D, et al. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med. (2002)
  3. Suzuki T, Morita M, Kobayashi Y, Kamimura A. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. Journal of the International Society of Sports Nutrition. 2016;13:6. doi:10.1186/s12970-016-0117-z. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759860/
  4. Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007
  5. Baguet, A et al.; Journal of Applied Physiology; “Important role of muscle carnosine in rowing performance;” July 2010;” 2005
  6. Roger C. Harris; et al.; “The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training
  7. Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. (2008)
  8. Choudhary, B., Shetty, A., & Langade, D. G. Efficacy of Ashwagandha (Withania somnifera [L.] Dunal) in improving cardiorespiratory endurance in healthy athletic adults.  (2015). Ayu, 36(1), 63.
  9. Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., & Bhattacharyya, S. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial  (2015). Journal of the International Society of Sports Nutrition, 12(1), 43.
  10. Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. J strength Cond Res. 2013;27(3):839-847. doi:10.1519/JSC.0b013e31825d9799. https://www.ncbi.nlm.nih.gov/pubmed/23443221
  11. De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. 2004;14(3):298-307. https://www.ncbi.nlm.nih.gov/pubmed/15256690
  12. Zhao H-B, Ma H, Ha X-Q, et al. Salidroside induces rat mesenchymal stem cells to differentiate into dopaminergic neurons. Cell Biology International. 2014;38(4):462-471. doi:10.1002/cbin.10217. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410750/
  13. Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional neuroscience, 11(4), 193-198.
  14. Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional neuroscience, 13(6), 283-290
  15. Reyes-Izquierdo, T., Nemzer, B., Shu, C., et al. (2013). Modulatory effects of coffee fruit extract on plasma levels of brain-derived neurotrophic factor in healthy subjects. British Journal of Nutrition. https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/modulatory-effect-of-coffee-fruit-extract-on-plasma-levels-of-brain-derived-neurotrophic-factor-in-healthy-subjects/8B291E8D053143AA5A8D33B65496B034/core-reader
  16. Futureceuticals. (2012). NeuroFactor Increases Plasma Levels of BDNF in Humans. http://docdro.id/kJEfIt7
  17. https://www.ncbi.nlm.nih.gov/gene/627
  18. https://www.dsm.com/markets/foodandbeverages/en_US/products/nutraceuticals/resvida.html
  19. Wightman EL, Reay JL, Haskell CF, Williamson G, Dew TP, Kennedy DO. Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation. Br J Nutr. 2014;112(2):203-213. doi:10.1017/S0007114514000737. https://www.ncbi.nlm.nih.gov/pubmed/24804871
  20. Kennedy DO, Wightman EL, Reay JL, et al. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Am J Clin Nutr. 2010;91(6):1590-1597. doi:10.3945/ajcn.2009.28641. https://www.ncbi.nlm.nih.gov/pubmed/20357044
  21. Casperson SL, Sheffield-Moore M, Hewlings SJ, Paddon-Jones D. Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein. Clinical nutrition (Edinburgh, Scotland). 2012;31(4):512-519. doi:10.1016/j.clnu.2012.01.005. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640444/
  22. http://ajcn.nutrition.org/content/94/3/809.full
  23. Magnusson, I; N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans.; Department of Clinical Physiology, Karolinska Institute, Huddinge Hospital; 1998
  24. Deijen, J; Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course.; Department of Clinical Neuropsychology, Vrije Universiteit; 1999
  25. Neri, D; The effects of tyrosine on cognitive performance during extended wakefulness.; Naval Aerospace Medical Research Laboratory; 1995
  26. Deijen JB, Orlebeke JF; Effect of tyrosine on cognitive function and blood pressure under stress . Brain Res Bull. (1994)
  27. Dollins AB, et al; L-tyrosine ameliorates some effects of lower body negative pressure stress . Physiol Behav. (1995)
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