Juggernaut Nutrition Irate Extreme | Train Like the Juggernaut You Are

Juggernaut Nutrition Irate Extreme

A hard lifter’s dream! Juggernaut Nutrition Irate Extreme gets the job done and beyond – even for the biggest of lifters

If there is one thing we are no stranger to here on PricePlow, it’s a good hardcore pre workout, and boy do we have something special for you from the team over at Juggernaut Nutrition, the brand built by former NFL football player Brock Pasteur. This man means business, and so does this pre workout!

That’s because today, we’re looking at their intense Irate Extreme pre workout, with an impressive label that is heavily stimulant based, but also doesn’t forget to add in the other pre workout necessities. This is the first product we’ve reviewed from Juggernaut Nutrition, and it most likely won’t be the last, because it’s a damn good one.

Before we break down this intense stimulant-driven panel, be sure to sign up for PricePlow’s coupon driven deals to make sure you’re getting the best prices, and sign up for Juggernaut Nutrition alerts to stay up to date with all that is happening with this rapidly-growing brand:

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Irate Ingredients

We love a good stimmed up supplement here at PricePlow, and with a label like this, Irate Extreme is sure to deliver. We’re getting a “moderate” 275mg caffeine here, from anhydrous and fast-acting citrate, but we say “moderate” in quotes because we’re also getting some PEA, DMHA, and just enough alpha yohimbine to make things exciting.

  • Mind and Focus Blend

    Let’s get the energy and focus started:

    • N-Acetyl L-Tyrosine (500mg)

      Juggernaut Nutrition Irate Extreme

      Two forms of caffeine, DMHA, PEA, ‘super synephrine’, and alpha-yo? And that’s not even getting into the pump formula?! Get ready to get wowed

      L-Tyrosine is an organic amino acid, which is the body’s precursor to the catecholamines, which are energetic and mood boosting chemicals, including epinephrine, norepinephrine, and dopamine.[1] By increasing levels of these catecholamines, you get a focus and mood boost, but the effects can even go further. Tyrosine has been shown to minimize stress and anxiety interestingly enough.[2,3] While the N-Acetyl version was originally touted to be more bioavailable, the straight L-Tyrosine form was seen as the better form more recently.[4] Regardless, we always enjoy seeing some tyrosine to help with our focus.

    • Caffeine Anhydrous (200mg)

      Perhaps the most well-known preworkout ingredient, we have our first stimulant as caffeine anhydrous. Caffeine is a central nervous system stimulant, which gives you a feeling of alertness and helps clear out the brain fog when you’re feeling tired.

      In addition to helping you wake up, caffeine does have some clinical research behind it in terms of strength. At doses of 5-6mg per kg of body weight, we actually have clinical strength gains shown.[5,6] For reference, a 70kg (154lbs) individual would need a dose of 350-420mg of caffeine. While we happen to be a bit short of that here, we do have another caffeine source up next to help close the gap between that.

      Another interesting note about caffeine is it’s lipolytic effects, allowing you to burn more fat by oxidizing fatty acids.[7,8,9]

      Caffeine is a substance that your body builds a tolerance to rather quickly. To minimize these effects, try cycling off from time to time to prevent becoming too tolerant to caffeine’s effects.

    • Caffeine Citrate (150mg)

      Juggernaut Nutrition

      Juggernaut Nutrition: The Unstoppable Force

      On top of caffeine anhydrous, we also have caffeine as caffeine citrate, which is caffeine bound to a citrate molecule. Anecdotally, we find this caffeine to hit a bit quicker than the usual anhydrous version.

      Due to the nature of this ingredient, only 50% of the actual mass is caffeine, meaning 75mg of caffeine is yielded. This brings our total caffeine amount up to 275mg. But if that isn’t enough for you, we have plenty of stims to go.

    • DMHA (2-amino-5-methylhexane) (150mg)

      DMHA, also known as 2-aminoisoheptane, is the most hardcore stimulant legally available right now. DMHA belongs to a class of substances known as aliphatic amines.[10] These chemicals give a strong focus boost and intense euphoria by releasing catecholamines, similarly to tyrosine, while simultaneously slowing the reuptake of those same neurotransmitters. We have 150mg of this strong stimulant here, so expect some serious energy and focus coming from just this ingredient alone.

      We’re left to believe that this is the 2-amino-5-methylheptane form of DMHA, which is also the stronger one. 150mg of this is no joke, especially when paired with the next two ingredients!

    • N-Phenethyl Dimethylamine (120mg)

      Up next is a form of PEA, known as N-Phenethyl Dimethylamine. This ingredient is known for its mood boosting properties, as PEAs generally are.[11] The issue with straight PEA is that it’s usually broken down fairly quick by the MAO enzyme, but this form has some protection against that. Two alkyl groups are attached to the PEA section of this molecule, offering a resistance to being quickly broken down.

      N-Phenethyldimethylamine 2D Receptor with Protection Highlighted

      N-Phenethyldimethylamine is like a PEA molecule, but with an N,N’ Alkyl section that also prevents MAO from cleaving it… meaning a longer-lasting euphoric ‘buzz’ than regular PEA

      This causes our euphoric sensations and some serious mood boosting to be prominent for much longer than usual. 120mg is an awesome dose, and especially with the DMHA, you can expect some serious mood boosting.

      If you feel Irate kick in a bit shorter than the average pre workout, it’s because of this ingredient.

    • Isopropylnorsynephrine (10mg)

      The void left by the exit of DMAA from the market allowed new ingredients to come to the forefront of the market. One of these is the ingredient isopropylnorsynephrine. Synephrine may look familiar to you from bitter orange extract, but this isopropyl version is substantially more potent.[12]

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      We know what fuels @tayluhh6’s workout…. what fuels yours?!?!

      Isopropylnorsynephrine gets its effects from its ability as a lipolytic, which means it frees up fatty acids for the body to use as energy.[13] This is definitely one of the stronger stimulants out there, so be cautious starting with a full scoop with this product.

    • Rauwolscine (2mg)

      Perhaps the most controversial ingredient over time at PricePlow, Rauwolscine, or also known as Alpha-Yohimbine. Alpha-Y, as it’s sometimes called, is an intense alkaloid that causes quite the impressive adrenaline releasing effect.[14] Similar to regular yohimbine, but with a different molecular orientation, it is a alpha-2 antagonist, which means it blocks this pathway. This may help in fat loss by helping the body remove fat and helping prevent fat storage in the future.[15]

      Since this is a 90% dose, the actual Alpha-Y dose is slightly below 2mg (1.8mg), which should be tolerated by most. But, some people experience intense effects with this ingredient, such as anxiousness or cold sweats.

      Speaking personally, we typically enjoy ~1.5mg as our preferred dose here, so we’ll often end up at just under a full scoop. As always with any hardcore pre workout, use half a scoop to assess dosage and slowly work your way up until you hit your peak! No reason to full scoop it right away – this product is strong.

  • Pump and Power

    If you were worried that this was simply a stim bomb, you can rest assured that Juggernaut Nutrition also took some other things into account. We have some daily ergogenics as well as some pump enhancers thrown in here.

    • Citrulline Malate (5,000mg)

      The staple pump ingredient that we love to see for nitric oxide production is good old fashioned citrulline malate. We have a 2:1 ratio here, giving us just over 3 grams of actual citrulline here, which is where we start to clinically see pump enhancing effects come into play.

      Citrulline

      The pathway we’re going for starts at the top right and goes down to the bottom right!

      Citrulline entered the market as an improvement over the amino acid arginine, due to the extremely low bioavailability of arginine. We quickly found out that arginine was nearly completely destroyed by the digestive tract when supplemented orally, giving us a minimal nitric oxide boost when using reasonable doses. Higher doses could have been used to remedy this issue, but the dose necessary would have been extremely large, and would cause gastrointestinal issues for many users. To remedy these issues, we now have citrulline.

      Thankfully, citrulline avoids being broken down in the gastrointestinal tract, which allows it to enter the bloodstream, and get converted to arginine. These boosted arginine levels then boost nitric oxide production, giving us vasodilation, and therefore, bigger pumps.[16] This plays especially well with another ingredient we have coming up soon as well.

      Citrulline also does more than just enhance your pumps, it also has a practical application as well. Citrulline can reduce your post-workout soreness, increase your overall training capacity, and help reduce fatigue.[17,18]

    • Beta Alanine (2,500)

      Another common pre workout ingredient, beta alanine is the ingredient responsible for the tingly sensation that some users experience when using pre workout. This harmless tingling sensation can be bothersome at higher doses, but shouldn’t be unbearable here. Beta alanine works by bonding with the amino acid histidine, forming a substance known as carnosine. This carnosine acts as a lactic acid buffer in your muscle cells, which comes with a whole slew of benefits associated with it. Supplementing with beta alanine has been shown to increase work capacity, increase peak power output, reduce fatigue, and improve overall athletic performance.[19-22]

      Beta Alanine Boosts Exercise Performance

      Beta Alanine Boosts Exercise Performance when taken 3.2g per day (but that was split amongst four separate doses)

      Beta alanine functions best during exercises lasting from 1-4 minutes, making it a sort of muscular endurance enhancer.[23,24] By allowing you to do more overall work, especially in high rep ranges, beta alanine supplementation can indirectly help with fat loss as well.[25]

      The clinical study with beta alanine used 3.2g, which is 700mg more than we have here, but split doses throughout the day. What this means is that to reach the total dose used in those studies, in may be a good idea to get some other forms of beta alanine supplementation elsewhere during the day in addition to taking this preworkout.

    • Creatine HCl (1,500mg)

      Creatine HCl is perhaps the most popular alternative form of creatine, and has been touted as superior due to its chemical properties. Creatine works by acting as a phosphate group donor to ADP. When we exercise, our bodies use ATP to contract our muscles. When the ATP is used, it becomes ADP and must be regenerated through our metabolic pathways.

      Juggernaut Nutrition Irate Extreme Review

      All smiles with this pre! As a thank you for using Taylor’s picture, use her TAY15 coupon if buying direct!

      What creatine does is give ADP a phosphate group, regenerating it into ATP, essentially acting as an energy bank for our muscles. While creatine monohydrate is certainly the most popular and research backed form, creatine HCl may have better solubility in water due to the inclusion of the hydrochloride group. Regardless, there isn’t much to back this up, and the doses needed of either form should be very similar.

      Creatine HCl does have one other advantage though, which is that users tend to experience less bloating and GI distress as compared to using monohydrate, which has been known to be upsetting to some stomachs.

      Unfortunately, we only have 1.5g here, which is about half of what we would like to see minimally for creatine doses daily, so you’ll still want to snag a bit more creatine elsewhere in the day… or just eat a ton of beef like we do and you’re good to go!

    • Agmatine Sulfate (500mg)

      Agmatine and Arginine

      Agmatine is similar to arginine, but WAY better, in our opinions!

      If citrulline is the offensive side of the nitric oxide battle, agmatine sulfate is the defensive side. Our bodies love homeostasis, so when we boost up our nitric oxide levels, our bodies want to bring them back down. To do so, we produce the enzyme known as arginase, which breaks down arginine in the bloodstream, something we simply do not want while we are trying to maintain max blood flow in the gym.[26,27]

      This is where agmatine comes in. Agmatine acts as an inhibitor to the arginase, which lowers the amount of arginase available to break down the arginine in the bloodstream. This allows us to keep our nitric oxide levels boosted longer than usual. An ingredient like this plays especially well when combined with a nitric oxide promoter, like citrulline.

      500mg is the minimal beginner dose we like to see for preworkouts, but it should make a nice addition to the pump section, which isn’t the main focus of this preworkout anyway.

  • Absorption

    Get your ingredients in:

    • Black Pepper Extract (5mg)

      Our last ingredient is black pepper extract, which enhances the bioavailability of the substances in a supplement, giving us the best absorption of the ingredients, making sure we utilize all of them as best as our body can.

The flavors

Below is a list of flavors, but you may need to head direct to JuggernautSupplements.com linked below if they’re not showing up in stock:

Juggernaut Nutrition Irate Extreme Flavors

Brock of Juggernaut Nutrition exclaims that they are serious about flavors!

    Brock tells us that they take their flavoring seriously, and with the one flavor we’ve tried (Braxton’s Sour Pals), we agree!

    Final Thoughts

    Juggernaut Nutrition has put together not only a respectable stim profile, but quite a hardcore one at that. With some exotic stimulants coupled with a two-pronged caffeine attack, Irate is certainly not to be messed with in the realm of hardcore preworkouts. As for flavors, you have some unique options that sound absolutely delicious, like Sour Pals and Rainbow Drops. We look forward to reviewing how this product goes, and whether the effects live up to the label.

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    About the Author: Mike Roberto

    Mike Roberto

    Mike Roberto is a research scientist and water sports athlete who founded PricePlow. He is a biohacker with extensive experience in supplementation and dietary modification, whose personal expertise stems from several "n=1" experiments done on himself.

    Mike's goal is to bridge the gap between nutritional research scientists and non-academics who seek to better their health in a system that has catastrophically failed the public.

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    References

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    2. Poly C, Massaro JM, Seshadri S, et al; “The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort”; The American Journal of Clinical Nutrition; 2011; 94(6):1584-1591; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252552/
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    9. Keijzers, G, et al; “Caffeine Can Decrease Insulin Sensitivity in Humans”; Diabetes Care; 25(2): 364-369; February 2002; http://care.diabetesjournals.org/content/25/2/364.long
    10. Ismet, Ara, et al; “Evaluation of Antimicrobial Properties of Two Different Extracts of Juglans regia Tree Bark and Search for Their Compounds Using Gas Chromatography-Mass Spectrum”; International Journal of Biology; Vol. 5, No. 2; 2013; Retrieved from http://www.ccsenet.org/journal/index.php/ijb/article/view/25651/15862
    11. Mesfioui, A., Math, F., Jmari, K., Hessni, A. E., Choulli, M. K., & Davrainville, J. (1998). Effects of Amphetamine and Phenylethylamine on Catecholamine Release in the Glomerular Layer of the Rat Olfactory Bulb. Neurosignals, 7(4), 235-243; https://www.karger.com/Article/Abstract/14548
    12. Mercader, J., Wanecq, E., Chen, J., & Carpéné, C. (2011). Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. Journal of Physiology and Biochemistry, 67(3), 443-452; doi:10.1007/s13105-011-0078-2; https://www.ncbi.nlm.nih.gov/pubmed/21336650
    13. Mercader, J., Wanecq, E., Chen, J., & Carpéné, C. (2011). Isopropylnorsynephrine is a stronger lipolytic agent in human adipocytes than synephrine and other amines present in Citrus aurantium. Journal of Physiology and Biochemistry, 67(3), 443-452; doi:10.1007/s13105-011-0078-2; https://www.ncbi.nlm.nih.gov/pubmed/21336650
    14. Rockhold, R. W., & Gross, F. (1981). “Yohimbine diastereoisomers: Cardiovascular effects after central and peripheral application in the rat”; Naunyn-Schmiedebergs Archives of Pharmacology, 315(3), 227-231; https://link.springer.com/article/10.1007%2FBF00499839
    15. Perry BD, U’Prichard DC; “(3H)rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors”; Eur J Pharmacol; 1981; https://www.ncbi.nlm.nih.gov/pubmed/6276200
    16. Schwedhelm, E., Maas, R., Freese, R., Jung, D., Lukacs, Z., Jambrecina, A., Spickler, W., Schulze, F., Böger, R. H; “Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism”; British journal of clinical pharmacology, 65(1), 51-9; 2007; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291275/
    17. Perez-Guisado; Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness.; Department of Medicine, University of Córdoba; 2010; Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/20386132
    18. Hickner, R; L-citrulline reduces time to exhaustion and insulin response to a graded exercise test.; Human Performance Laboratory, East Carolina University; 2006; Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/16679980
    19. Hill C A, et al; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity”; J Amino Acids; ; 2007; 32: 225−233; https://www.ncbi.nlm.nih.gov/pubmed/16868650
    20. Stout JR, et al; “Effects of twenty-eight days of beta-alanine and creatine monohydrate supplementation on the physical working capacity at neuromuscular fatigue threshold”; J Strength & Cond Research; 2006 20(4): 928−931; https://www.ncbi.nlm.nih.gov/pubmed/17194255
    21. Smith A E, et al; “The effects of beta-alanine supplementation and high-intensity interval training on neuromuscular fatigue and muscle function”; Eur J Appl Physiol; 2009; 105: 357−363; https://www.ncbi.nlm.nih.gov/pubmed/18989693
    22. Van Thienen R, et al; “Beta-alanine improves sprint performance in endurance cycling”; Medicine & Science in Sports & Exercise; American College of Sports Medicine; 2009; https://www.ncbi.nlm.nih.gov/pubmed/19276843
    23. Hoffman, J R, et al; “β-Alanine Ingestion Increases Muscle Carnosine Content and Combat Specific Performance in Soldiers”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; Mar. 2015; https://www.ncbi.nlm.nih.gov/pubmed/25510839
    24. Stout, J R, et al; “Effects of Beta-Alanine Supplementation on the Onset of Neuromuscular Fatigue and Ventilatory Threshold in Women.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; 2006; https://www.ncbi.nlm.nih.gov/pubmed/17136505
    25. Kern, B D, and T L Robinson; “Effects of β-Alanine Supplementation on Performance and Body Composition in Collegiate Wrestlers and Football Players.”; Current Neurology and Neuroscience Reports; U.S. National Library of Medicine; July 2011; https://www.ncbi.nlm.nih.gov/pubmed/21659893
    26. Demady, D; “Agmatine Enhances the NADPH Oxidase Activity of Neuronal NO Synthase and Leads to Oxidative Inactivation of the Enzyme”; Molecular Pharmacology; January 2001, 59(1) 24-29; http://molpharm.aspetjournals.org/content/59/1/24.long
    27. Galea, E, “Inhibition of mammalian nitric oxide syFinal Thoughts: Hydraulic brings the houseFinal Thoughts: Hydraulic brings the housenthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine”; Biochemical Journal May 15, 1996, 316 (1) 247-249; http://www.biochemj.org/content/316/1/247

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