Nugenix Perform: Nitrosigine-Powered Sexual Vitality Support

The connection between cardiovascular health and sexual performance has long been understood by health enthusiasts. After all, healthy blood flow is crucial for both heart health and intimate moments. In recent years, research has increasingly focused on nitric oxide’s role in supporting this vital function.

Nugenix Perform delivers clinical-strength Nitrosigine with powerful botanicals to maximize intimate performance and male vitality. Science-backed formula works in 30 minutes to enhance blood flow and arousal when it matters most.

In our recent article about “The Power of Nitric Oxide: A Key to Healthy Aging and Vitality with Nitrosigine“, we explored how this remarkable molecule supports cardiovascular health and overall vitality. While many know nitric oxide’s role in exercise performance, its benefits extend far beyond the weight room – especially when it comes to intimate moments.

Nugenix Perform brings Nutrition21’s flagship ingredient Nitrosigine to the bedroom, where its clinically-validated blood flow support serves as the foundation of this comprehensive formula for male vitality. But Perform isn’t just about boosting nitric oxide and blood circulation – it’s strategically formulated with additional botanicals that maximize sexual response, support arousal and excitement, and supercharge stamina and performance through multiple pathways.

Perform: Nitrosigine for Blood Flow, with More For Vitality

The formula combines modern nutritional science through Nitrosigine with time-tested ingredients like maca root, Asian ginseng, and black ginger extract — which has a powerful compound inside you’ll want to learn about. This provides a dual-action approach: enhanced blood flow support alongside natural botanical extracts traditionally used to promote libido and sexual vitality.

In this article, we’ll analyze the research behind each ingredient in detail below, but the synergy between these carefully-selected compounds makes the Nitrosigine-powered Perform a uniquely comprehensive option for men seeking to optimize their intimate experiences.

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Let’s dive into the science behind each ingredient to understand how they work together to support male vitality and performance:

Nugenix Perform Ingredients

Each 3-tablet serving of Nugenix Perform includes the following:

• Nitrosigine (Arginine Silicate Inositol) – 1500mg

  At the foundation of Nugenix Perform is Nitrosigine®, a patented,^[1] unique inositol-stabilized arginine silicate complex that’s been clinically shown to boost nitric oxide production and enhance blood flow.^[2]

  While many know Nitrosigine for its benefits in sports nutrition, its role as a superior nitric oxide booster make it perfectly suited for supporting intimate vitality. The science behind it is compelling: Nitrosigine significantly enhances blood flow by increasing serum arginine levels in as little as 30 minutes and and for up to 6 hours.^[2] This sustained elevation is crucial, as arginine is the primary precursor to nitric oxide, a molecule that induces vasodilation by relaxing blood vessels.^[3]

  In clinical research, a single 1500mg dose of Nitrosigine – the exact amount in Perform – increased flow-mediated dilation (a measure of blood flow and vascular function) by an impressive nearly 25%.^[4] And as mentioned above, the effect works quickly and lasts for hours.^[2]

  What makes Nitrosigine particularly effective is its unique and patented structure which offers a effective form of arginine that can be quickly absorbed by the body. This rapid absorption means you get more benefit from a smaller dose, making it an efficient choice for supporting healthy blood flow whether you’re headed to the gym or preparing for intimate moments.

  Outperforms equivalent amounts of L-citrulline for purposes of blood flow

  In 2020, independent researchers published a study showing that a 1.5 gram dose of Nitrosigine was equivalent to 8 grams of citrulline malate in terms of efficacy. This is the study that showed the increased flow-mediated dilation by a phenomenal 25% — and it did so at just 1/5th the dose – proving Nitrosigine to be the superior nitric oxide booster!^[4]

  

  This matters greatly in a capsule-based supplement. To get the same effects from citrulline malate, you’d need 11 or 12 large capsules! Instead, Nitrosigine allows for just 3 tablets, and there’s room for the additional ingredients below.

  Additionally, it’s important to note that the study comparing Nitrosigine against citrulline malate employed healthy participants,^[4] which is more meaningful, as healthy people generally already have good blood flow.

  The secret ingredient to healthy aging and whole-body optimization

  While Perform is marketed as a sexual health and vitality booster, its star ingredient Nitrosigine is often utilized in other healthy aging and sports performance products as well. In one recent study, four days of Nitrosigine supplementation led to improved blood flow response to exercise.^[5] The researchers measured the participants’ leg circumference before and after exercise, noting the increases, and the participants also reported improved feelings of energy (perceived energy) after an intense leg extension exercise protocol.^[5]

  There are also other benefits, such as improved cognitive flexibility, which are touched upon in our recent article, “The Power of Nitric Oxide: A Key to Healthy Aging and Vitality with Nitrosigine“.

  

  Ultimately, the 1500mg clinical dose of Nitrosigine in Perform demonstrates Nugenix’s commitment to evidence-based formulation. This foundational ingredient sets the stage for the formula’s other botanical ingredients to provide comprehensive support for male vitality.

• Maca Extract – 100mg

  Maca (Lepidium meyenii), a root vegetable native to the Peruvian Andes, has been cultivated for over 2000 years and traditionally used to enhance vitality and sexual function. Modern research has begun to validate many of these traditional uses, particularly regarding its effects on blood flow and sexual health.^[6]

  In Nugenix Perform, maca works alongside ofi Nitrosigine to support blood flow and vitality. The root contains unique compounds called macamides, which have demonstrated benefits for sexual function and energy levels. Research suggests that maca’s effects aren’t tied to changes in hormone levels, but rather through other biological pathways including nitric oxide production and antioxidant effects.^[7]

  Different maca varieties provide unique and complementary benefits – black maca has shown particular efficacy for male sexual function and physical performance, while red maca contributes additional antioxidant compounds. Clinical research indicates that maca supplementation can support healthy sexual desire and satisfaction when taken consistently over 8-12 weeks.^[8]

  When combined with Nitrosigine’s clinically-validated NO-boosting and blood flow support, maca helps create a comprehensive formula for male vitality through multiple complementary mechanisms of action.

• Asian Ginseng Extract (5% Ginsenosides) – 100mg

  

  Asian Ginseng Extract, standardized to 5% ginsenosides, is a key ingredient in Nugenix Perform’s comprehensive formula for supporting male vitality. This adaptogenic herb has been used for thousands of years in traditional medicine and is now backed by modern research supporting its benefits for blood flow and energy.^[9]

  The 5% ginsenoside standardization is particularly important, as these active compounds are responsible for ginseng’s beneficial effects on circulation. Research shows that ginsenosides can help enhance nitric oxide production and improve blood flow, which may support healthy erectile function.^[10]

  Beyond circulation, Asian Ginseng Extract has demonstrated adaptogenic properties that can help combat fatigue and support overall vitality. Clinical studies suggest it may help improve energy levels and physical performance when taken consistently.^[11]

  The inclusion of standardized Asian Ginseng Extract complements Nugenix Perform’s other ingredients like Nitrosigine, working together to support healthy blood flow and male vitality through multiple complementary pathways. This traditional herb brings both time-tested benefits and modern scientific validation to the formula.

• Spectra – 100mg

  Spectra is a comprehensive botanical blend that serves as one of the supporting ingredients in Perform. This scientifically-validated ingredient combines extracts and concentrates from over 29 fruits, vegetables, and herbs, including coffee fruit, green tea leaf, broccoli sprout seed, onion bulb, apple skin, acerola fruit, and an array of berries and leafy greens. What makes Spectra unique is its standardization to specific bioactive compounds that support cellular energy production and antioxidant defense systems.

  In the context of Perform’s focus on blood flow and vitality, Spectra plays an important complementary role. Research has shown that a single 100mg dose of Spectra – the amount included here – can significantly reduce reactive oxygen species (ROS) generation while simultaneously increasing nitric oxide bioavailability in healthy adults. In one key clinical study, Spectra demonstrated the ability to inhibit cellular ROS generation by up to 17% and improve mitochondrial oxygen consumption,^[12] suggesting enhanced cellular energy production and metabolic activity.

  

  The ingredient’s multi-faceted effects on both oxidative stress reduction and nitric oxide enhancement make it a smart addition to Perform’s formula. By supporting healthy cellular function and nitric oxide levels through complementary pathways, Spectra helps create a more comprehensive approach to supporting male vitality and performance.

• Epimedium Extract (aerial parts) – 100mg

  Epimedium, also affectionately known as horny goat weed, is one of the key supporting ingredients in Nugenix Perform’s formula for male vitality. It’s traditionally been used in Chinese medicine as an aphrodisiac and is known for containing a bioactive compound called icariin which exhibits PDE5 inhibitor activity.^[13]

  Research has shown that icariin may help enhance erectile function through multiple mechanisms. Studies in animal models demonstrate that icariin increases intracavernosal pressure and nitric oxide synthase expression in a dose-dependent manner.^[14]

  Beyond its PDE5 inhibition properties, icariin also appears to have beneficial effects on smooth muscle proliferation and demonstrates neurotrophic properties that could be particularly valuable for men dealing with erectile difficulties related to some metabolic conditions.^[15]

  While promising research exists on epimedium’s mechanisms of action, human clinical trials remain limited. However, its inclusion in Nugenix Perform’s formula, appears strategic given its potential to support multiple pathways related to erectile function and male sexual health.

• Black Ginger Extract (rhizome) (2.5% 5,7-dimethyoxyflavone) – 90mg

  Black ginger (Kaempferia parviflora) is a fascinating ingredient that demonstrates multiple complementary pathways to support male performance and blood flow.

  A landmark 2-month clinical study demonstrated black ginger’s impressive effects on male sexual response. When healthy older men (average age 65) took 90mg of black ginger extract daily – the exact dose found in Nugenix Perform – researchers observed significant improvements in several measures of sexual response.^[16]

  

  Nutrition21 is a leader in the sports nutrition industry, making huge strides towards supplement research, safety, transparency, and efficacy

  Specifically, the study found that black ginger extract helped:

  • Enhance physiological arousal and excitement
  • Support a healthy erectile response
  • Decrease response time to visual sexual stimuli
  • Improve overall sexual performance

  These benefits became apparent after just one month of supplementation and continued to improve through the second month!^[16]

  Potential mechanisms and one very interesting constituent (5,7-DMF)

  At its core is 5,7-dimethoxyflavone (5,7-DMF), a powerful bioactive compound that acts as a PDE5 inhibitor.^[17] Research has revealed that 5,7-DMF exhibits significant vasodilatory effects through three primary mechanisms:

  1. It increases potassium efflux and inhibits calcium influx in vascular smooth muscle cells, promoting relaxation of blood vessels.^[18]
  2. It enhances nitric oxide production and supports endothelium-dependent vasodilation through the NO-cGMP pathway.^[18]

  

  3. It acts as a PDE5 inhibitor, with 5,7-DMF showing the highest potency among tested compounds and a favorable selectivity ratio of 3.71 for PDE5 over PDE6.^[17]

  This multi-pathway approach makes black ginger extract an ideal complement to Nitrosigine in Nugenix Perform’s formula. While Nitrosigine provides powerful acute vasodilation, black ginger’s 5,7-DMF works through additional mechanisms to support sustained vascular function and healthy erectile response. The standardization to 2.5% 5,7-dimethoxyflavone ensures consistent delivery of this key bioactive compound.

How to Take Perform

Nugenix Perform offers flexible dosing options that align with your needs and schedule. The standard daily serving is three tablets, which can be taken with or without food. However, timing can be optimized based on your goals:

• For general daily vitality support, you can take the full three-tablet serving any time of day. The active ingredients, particularly Nitrosigine, work to support healthy blood flow throughout your system over time.
• When using Perform situationally, consider taking it approximately 30-60 minutes before intimate activity. This timing aligns with Nitrosigine’s rapid-acting properties – research shows it begins supporting nitric oxide production within 30 minutes of consumption.

Built for regular use

For best results, Nugenix recommends using Perform alongside their other products, particularly their testosterone support formulas. However, always consult with a healthcare provider before combining multiple supplements, especially if you have any underlying health conditions or are taking medications.

Remember: Perform is designed for daily use, but you can adjust the timing to align with your specific needs and lifestyle. The key is consistency with your chosen dosing schedule while listening to your body’s response.

Conclusion: Male Vitality with More from Nitrosigine

The benefits are clear and concise, right there in Nugenix’s website:

• Boost Nitric Oxide
• Maximize sexual response
• Enhance arousal & excitement
• Supercharge stamina & performance

Nugenix Perform represents an innovative approach to male vitality support, anchored by the clinically-validated Nitrosigine from Nutrition21. By combining modern nitric oxide boosting technology with traditional botanicals that support arousal and desire, Perform offers a comprehensive solution for men seeking to optimize their intimate experiences.

Nitrosigine isn’t just for workouts anymore—it’s redefining nitric oxide support for healthy aging and vitality. Backed by clinical studies and patented innovation, it’s the superior choice for boosting nitric oxide and supporting an active lifestyle.

What sets Perform apart is its versatility – whether used daily for ongoing vitality support, situationally before intimate moments, the formula delivers both quick-acting and sustained benefits. The inclusion of Nitrosigine at its research-backed 1500mg dose provides reliable nitric oxide boosting and blood flow support, while the carefully selected botanical extracts work through complementary pathways to enhance the overall experience.

This innovative product aligns perfectly with Nutrition21’s vision of Nitrosigine as more than just a pre-workout ingredient – it’s a versatile compound that supports cardiovascular health and vitality across multiple aspects of life.

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