USPLabs has been touting their new pre workout supplement, Modern PRE, which has gone into beta testing in late November 2015!
We know very little about it, except that USP is extremely excited about what’s coming. The trend in the best pre workout supplements has been towards the “fully loaded one scoop wonders” area, so we’re hoping it will be of that style.
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Here was the first picture to leak:
Looking at the front label, we can see that the “Less Soreness” claim is backed up by this statement:
“Based on emerging research of L-Citrulline Malate at the amount contained in 2 scoops. Testing was performed on resistance-trained males comprising mostly of compound exercises such as bench press, squat variations, chinups, pushups, and leg press.”
So what study was that from?
The one that used 8g citrulline malate!
So we believe Modern PRE will have 4g citrulline malate per scoop!
In fact, USP’s marketing shows 8g citrulline malate 2:1, meaning it will have 5.333g citrulline per serving, or 2.667g per scoop!
In addition, each scoop will have 250mg citicoline per 2-scoop serving, or 125mg per scoop.
Now for the details:
Modern Pre Ingredients
USPLabs latest pre workout utilizes a completely open label that combines energy, focus, pumps, and endurance. You’ll like it at one scoop, but if you can handle 350mg of caffeine then you’ll get full clinical doses of all ingredients at 2 scoops!
Doses listed below are for ONE scoop:
Citrulline Malate 2:1 (4g)
One the short list of ingredients we want in a pre workout that improves pumps and stamina, Citrulline Malate is at the very top. This ingredient has become a top choice with most new companies when it comes to actually delivering noticeable improvements in nitric oxide production.
Citrulline Malate is more bioavailable that L-Arginine and increases serum levels of arginine in the body better than supplementing with L-Arginine. This results in greater NO production in the body leading to enhanced blood flow and a significantly bigger pump.
Citrulline malate functions as a buffer in the the body, helping to remove ammonia and lactic acid accumulation in skeletal muscle. All of this adds up to better endurance and ATP production[2,3,4,5] so you can work out longer and harder.
Note that Modern Pre here has a 2:1 citrulline malate blend, so you actually get 2.667g of citrulline and 1.333g malic acid in each scoop. One scoop will be enough for a good pump, but two scoops – if you can handle the caffeine – will really be where it’s at.
CarnoSyn® Beta Alanine (1g)
Everyone is familiar with the tingle-inducing amino acid beta alanine. It binds to histidine and forms carnosine, a powerful buffer in muscles that prevents lactic acid buildup.
Buffering lactic acid helps eliminate the burning sensation you get in your muscles during extreme workouts which leads to host of benefits including:
- Greater Endurance
- Increased Strength
- Less Fatigue
- Higher Power Output
As you may know, the best studies on beta alanine use 3.2g or more spread across a day, so if this is your only chance to get BA in, and you want to maximize your muscular endurance, you’ll need to add some bulk beta alanine elsewhere in your day.
L-Arginine HCl (1g)
Arginine is the amino acid responsible for supporting optimal blood flow and increasing levels of nitric oxide in the body. One would think that supplementing with oral arginine would lead to even greater serum levels and yield more nitric oxide and better pumps and vasodilation.However, it turns out arginine is all the bioavailable in the body, and has mixed results in terms of actually increasing NO production in the body.[10,11]
Perhaps arginine has been thrown a bit too much under the bus – many users still do enjoy it. We do too, but we’d honestly rather have a smaller dose of agmatine or nitrate instead. Still, it probably added next to nothing to the cost, so why not?
Creatine Anhydrous (1.5g)
Users of USPLabs ModernCreatine are quite familiar with this ingredient. Creatine anhydrous is regular creatine monohydrate minus the water molecule. On a gram-per-gram basis, anhydrous provides slightly more creatine than monohydrate.
However, a more pure creatine doesn’t necessarily mean it’s more effective. No research exists to support anhydrous, or any other form of creatine for that matter, as being superior to monohydrate. You’ll still enjoy the same lean mass gains and improvements in power and strength as when you’re using monohydrate.[13,14,15]
Betaine Anhydrous (1.25g)
Another of our favorite ingredients is betaine, a.k.a. trimethylglycine. This awesome little compound has become incredibly popular in virtually all pre workouts coming out this year, and certainly appears that way going forward.
Several clinical trials have shown betaine to improve endurance, power, and muscle protein synthesis.[16,17,18] There’s even some research to suggest it works synergistically with creatine to improve the body’s production of it, and reduce soreness as well.[19,20]
We’ve recently expounded on the many benefits of including carbs in your pre and intra workout nutrition, and it’s refreshing to see more companies start to jump on the bandwagon.
Carb10™ is a fast acting carbohydrate derived from peas. As we’ve seen with highly-branched cyclic dextrin (HBCD), Carb10™ has a low osmolality that speeds gastric emptying. This means that the carbs don’t hang around in your stomach leading to a heavy or bloated feeling.
The big difference between the two is that Carb10 doesn’t insulin to the levels that other forms of pre workout carbs do. When compared to maltodextrin, Carb10™ has a 27% lower blood glucose response and an remarkable 82% lower insulin response!
This leads to better performance during your workouts, with no chance of “bonking” as well as having reduced muscle soreness afterwards.
The issue we have is that there are only 3g per scoop of carbs in this pre workout. You’ll burn through those by the end of your first exercise. If we’re going to have carbs in a pre workout, let’s get serious about it, and not just sprinkle them in for headlines.
Caffeine Anhydrous (175mg)
USPLabs keeps its energy component simple and straightforward. Rather than throw in 10 different types of stims as you’ve seen with other recent pre workout formulas, ModernPre+ uses the old energy stalwart, good old caffeine!
Caffeine’s benefits are widely recognized and hardly need any discussion. What we will note is the dose in one scoop. This should be good for most users, but for those that really need a heavy hit, two scoops sits below the 400mg level, which makes us happy. When you start to exceed 400mg, caffeine’s ergogenic qualities go south rather quickly.[22,23]
Cognizin™ Citicoline (125mg)
Choline supplements are the go-to choice when looking to improve focus during your workouts. Most will see choline bitartrate which is a cheaper, less bioavailable form of supplemental choline.
USPLabs spares no expense in using the more bioavailable, and expensive, citicoline which is much better utilized by the body. Choline helps you to feel more “in the zone” during your workout. This leads to a stronger “mind-muscle” connection when lifting. Your workouts will now be more productive as you’ll really be able to break down each and every muscle fiber during each set, which translates to bigger and better gains all around!
The Modern Pre Beta Tubs
On November 18, 2015, USPLabs posted the following picture of slick black boxes for their beta testers:
This comes immediately after the indictment of seven USP executives by the Department of Justice, so the timing is a bit crazy, but USPLabs wasn’t charged for any wrongdoings in their latest generations of products, and it’s business as usual for the marketing and production teams!
USPLabs released their official statement on the morning of November 19, which we included in the post linked above.
Until then, it’s Modern PRE time! Who’s in?!
USPLabs typically slowly releases several flavors, and the last version of Jack3d Advanced had some incredible flavoring (dragon berry was phenomenal), so our hopes are high.
No artificial colors
This product will be only naturally colored, which is a trend that we’ve seen growing for a while, and one that we typically support. USPLabs getting back to their roots with that one.
Overall, it’s the first ever non-proprietary pre workout supplement from USPLabs, which is great to see. It takes the safe route: one stimulant, one main pump agent, two safe and proven ergogenics, and one main focus boosting agent. It hits several of the checkboxes users want when going through our best pre workout supplement buyer’s guide.
If we could change just one thing, it’d be to bump the citicoline up, even if that came at the expense of the carbs or arginine. We also enjoy carbs more in pre workouts lately, but 6g in a max dose isn’t exactly a massive number. It’s at the awkward point where you begin to wonder if the insulin spike this causes will clear out more glucose than the 6g itself!
Regardless, if your caffeine tolerance is in the 300-350mg range and you aren’t looking for other stims or complexity, you’re probably going to love this. Moreover, you will see gains if you haven’t been taking adequate creatine and/or betaine doses.
And at this point, you should know that USPLabs isn’t taking many risks – they really haven’t since 2013. If you still want DMAA pre workouts, they’re out there, you’ll have to look elsewhere.
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- Curis E., et. al; “Citrulline and the gut;”; Current Opinion in Clinical Nutrition and Metabolic Care; September 2007
- Giannesini B., et. al.; European Journal of Pharmacology; “Citrulline malate supplementation increases muscle efficiency in rat skeletal muscle;” September 2011
- Perez-Guisado J, Jakeman PM; Journal of Strength and Conditioning; “Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness;” May 2010
- Hickner RC. et. al.; Medicine and Science in Sports and Exercise; “L-citrulline reduces time to exhaustion and insulin response to a graded exercise test;“
- Moinard C., et. al.; The British Journal of Nutrition; “Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: the Citrudose pharmacokinetic study;” April 2008
- Baguet, A et al.; Journal of Applied Physiology; “Important role of muscle carnosine in rowing performance;” July 2010;” 2005
- Roger C. Harris; et al.; “The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training“
- Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007
- Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. (2008)
- Fahs CA, Heffernan KS, Fernhall B; Hemodynamic and vascular response to resistance exercise with L-arginine . Med Sci Sports Exerc. (2009)
- Tang JE, et al; Bolus arginine supplementation affects neither muscle blood flow nor muscle protein synthesis in young men at rest or after resistance exercise . J Nutr. (2011)
- Jager,R.,et al., Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Amino Acids, 2011. 40(5): p. 1369-83.
- Netreba, A; [Creatine as a metabolic controller of skeletal muscles structure and function in strength exercises in humans].; Ross Fiziol; 2006
- Bemben, M; The effects of supplementation with creatine and protein on muscle strength following a traditional resistance training program in middle-aged and older men.; Neuromuscular Lab, Dept. Health & Exercise Science, U. Oklahoma; 2010
- Chilibeck, P; Effect of creatine ingestion after exercise on muscle thickness in males and females.; College of Kinesiology, University of Saskatchewan; 2004
- ee EC, et al. Ergogenic effects of betaine supplementation on strength and power performance. J Int Soc Sports Nutr. (2010)
- Effect of betaine supplementation on power performance and fatigue
- del Favero S, et al Creatine but not betaine supplementation increases muscle phosphorylcreatine content and strength performance . Amino Acids. (2012)
- holewa, J; Effects of betaine on body composition, performance, and homocysteine thiolactone.; Department of Kinesiology, Recreation, and Sport Studies, Coastal Carolina University; 2013
- Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise.
- Pasman, W; The effect of different dosages of caffeine on endurance performance time.; Department of Human Biology, University of Limburg; 1995
- Desbrow, B; The effects of different doses of caffeine on endurance cycling time trial performance.; School of Public Health, Research Centre for Clinical and Community Practice Innovation, Griffith Health Institute, Griffith University; 2012