C4 Neuro – Cellucor’s C4 with FOCUS

C4 Neuro is the latest incarnation of Cellucor's pre workout that packs a lot of the things you love about the standard product plus the inclusion of a potent nootropic blend to give tunnel-vision focus.

C4 Neuro is the latest incarnation of Cellucor’s pre workout that packs a lot of the things you love about the standard product plus the inclusion of a potent nootropic blend to give tunnel-vision focus.

Cellucor has been exceedingly busy this year, not only with upgrading the vast majority of their products and releasing the G4 line, but they’ve also turned their extremely popular pre workout, C4, into a brand of its own.

This year has seen the creation of the new C4 Formula, C4 Mass, C4 50x, C4 Ripped, C4 On the Go and now…C4 Neuro!

Looking to lose weight?… Get C4 Ripped

Need a more energy?… Go for C4 50x

But if you want tunnel-vision focus? That’s when it’s time for C4 Neuro.

You have to appreciate C4’s marketing here. Each contain the same base ingredients, more or less, and then they sprinkle in a few other ingredients to tailor the product for a certain crowd.

So C4 Neuro is something a little familiar, and a little different. We’ll cover the ingredients down below, but first make sure to sign up for PricePlow alerts and check the best deal:

Cellucor C4 Neuro - Deals and Price Drop Alerts

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C4 Neuro Ingredients

C4 Neuro contains the same base as the basic C4 G4 product with the only ingredient missing being the Velvet Bean extract from the Explosive Energy Blend. However, what sets Neuro apart for the rest is the nootropic blend included, aptly named Neuro Blend. Enough talk though, let’s see what we’ve got:

  • C4 Neuro Blend (665mg)

    C4 Neuro Ingredients

    C4 Neuro contains a prop blend of very potent nootropics that should bring some incredible focus. We just hope there’s enough of each one to really “feel” its effects.

    The honest truth is that it’s going to come down to the dosing inside of this proprietary blend, and that’s something we simply don’t have access to.

    We love ALCAR, but if we have too much of it, we won’t get enough Alpha GPC (which we really start feeling at 250mg).

    On the other hand, ALCAR is something we really start to feel at much higher doses, such as 1-1.5g, so this will be the first and hopefully last time you ever hear us say that we actually hope ALCAR is under-dosed — just to ensure enough Alpha GPC!

    Also, don’t forget that the “base” C4 blend has some N-Acetyl L-Tyrosine, another focus booster to discuss below.

    • ALCAR (Acetyl L-Carnitine)

      C4 Neuro

      This image taken from @cellucor is of Cellucor ambassador @jordanke holding C4 RIPPED, but we doubt you’ll complain about that

      Acetyl L-Carnitine (ALCAR) is a more bioavailable form of the amino acid L-carnitine that has the unique capability to cross the blood-brain barrier. It’s also a PricePlow favorite when it comes to improving focus and concentration, but only in higher doses mentioned above.[9]

      In case that’s not enough to warrant it’s inclusion, ALCAR also works with caffeine to increase “fatty acid dumping.” Here, fatty acids are eliminated from the body when it enters “fat burning” mode.[10]

      With all that said, we believe that not enough pre workouts have this incredible ingredient.

    • Alpha GPC

      Alpha GPC is one of the most effectively absorbed forms of choline supplements around. If we can’t have citicoline in a pre workout, we want Alpha GPC.

      Studies on this potent nootropic show it not only boosts mood and focus, but also increases the “mind muscle connection.” Alpha GPC is a choline-containing compound that boosts production of the “learning neurotransmitter” acetylcholine.[11]

      Additional research shows that Alpha GPC also improves endurance, power, and post-workout Growth Hormone (GH) levels.[12,13,14]

      The dosing of this ingredient is the make-it-or-break-it situation for C4 Neuro. Since it’s in a proprietary blend, there will really only be one way to find out…

    • Zembrin®

      Zembrin offers everything you want in a nootropic...better focus, mood, and cognition, all with less stress and anxiety. Image courtesy Zembrin.com

      Zembrin offers everything you want in a nootropic…better focus, mood, and cognition, all with less stress and anxiety. Image courtesy Zembrin.com

      Zembrin® is the trademarked form of the herbal extract Sceletium tortuosum, also known as Kanna.  Clinical studies on the extract show that it can improve mental performance and overall cognitive function.[15,16]

      Furthermore, there are indications that in may positively impact overall mood and well-being by reducing stress and anxiety.[17]

      This is one ingredient that we’ve definitely “felt” and believe there is merit to the mood boost study cited above.

    • Huperzine A

      The final ingredient in the Neuro blend is another potent nootropic Huperzine A, a.k.a. Toothed Clubmoss Extract. Instead of increasing production of acetylcholine, like Alpha GPC does, Huperzine prevents its breakdown.

      Huperzine does this by inhibiting acetylcholinesterase, the enzyme directly responsible for acetylcholine’s breakdown the acetylcholine.[18] This means that Huperzine indirectly increases amounts of this all-too-important neurotransmitter by helping it “hang around” longer.

  • Beta Alanine (1.6g)

    Much like all the other iterations of C4, C4 Neuro contains the proven endurance booster, beta alanine. This amino helps increase serum carnosine levels in the body which enhances the body’s capacity to offset the “burn” by removing lactic acid build up.[1]

    This leads to better endurance, greater power and strength, and less fatigue.[2,3,4] You’ll get half of the recommended 3.2g. So you’ll either need to use 2 scoops, or add some bulk BA to this to get the full clinical effects.

  • Creatine Nitrate (1g)

    Creatine nitrate is a combination of creatine and nitrate.  Each gram contains 67.5% creatine and 32.5% nitrate, meaning you’ll get 675mg of creatine in each. Now, this is hardly enough to meet your 3-5g of creatine, but that’s not why it’s here.

    We’re more interested in the 325mg of nitrate that’ll help set the stage for some decent pumps, and will work even better when used at two scoops.

    Nitrates will help improve blood flow, endurance, power, and most importantly pumps![5,6,7]

  • Arginine AKG (1g)

    L-Arginine Pathway

    How L-Arginine Works – but the main reason we like it in the new C4 is due to the prevention of nitrate tolerance

    Arginine AKG (AAKG) was the primary pump ingredient in many pre workouts years ago, but has fallen by the wayside in favor of other more popular pump inducers like Citrulline and Nitrosigine.

    You may wonder why include it in C4? Well, as it turns out, arginine is synergistic with nitrates.[8] It reduces nitrate tolerance, so you won’t get “used” to its effects and feel the need to constantly increase the amount, as many do with caffeine.

  • Explosive Energy Blend (350mg)

    • N-Acetyl L-Tyrosine

      N-Acetyl L-Tyrosine (NALT) is the main focus booster in all the other C4 iterations, but here, it’s playing backup to the standout Neuro blend we just covered. Much like ALCAR and Alpha GPC, we’re huge fans of L-Tyrosine, and NALT is the most bioavailable and best absorbed form of the amino acid.[19]

      Studies on tyrosine supplementation shows it can improve mental focus.[20,21] It does this by increasing the production of noradrenaline and dopamine in the body, two big time neurotransmitters. In addition to improving focus, NALT will help support a healthy overall mood while reducing anxiety and stress.[22,23]

      Normally we would argue that there may not be enough NALT in C4. However, adding it to the C4 Neuro blend as well as the caffeine and TeaCor below, and now you might be speaking our language.

    • Caffeine Anhydrous (150mg)

      Caffeine needs little to no introduction. It’s a proven commodity in fitness circles for its ability to increase energy, focus, stamina, and recovery.

      The amount included in one scoop of C4 is a modest 150mg, enough for some, but most likely not enough for the stim junkie crowd out there. This will most likely mean people will need to use 1.5 to 2 scoops to get a solid energy kick. The upside to this is that you’ll experience increased focus and pumps from the extra amounts of all the other ingredients.

    • TeaCor™

      C4 Neuro will come in at least 2 flavors, we're also hoping the deceptively delicious Cherry Limeade from the new CN3 also makes an appearance in the line up!

      C4 Neuro will come in at least 2 flavors, we’re also hoping the deceptively delicious Cherry Limeade from the new CN3 also makes an appearance in the line up!

      TeaCor is the trademarked form of theacrine, and well known in the world of Cellucor products. It’s an alkaloid naturally synthesized from caffeine in certain plants, such as the Kucha plant.[24]

      This is the ingredient that helps provide long-lasting energy and makes caffeine hit “like the first time” so you’re not going to continually needing to further increase the dosage.[25] Studies on theacrine show that it prevent tolerance buildup to caffeine helping to promote a longer, smoother energy with lower doses of caffeine.[26]

      This should help curtail many from needing to use 2 or more scoops as users of previous C4 incarnations have claimed. We really like this ingredient and expect it to show up more and more now that the kibosh has been put on picamilon more or less…

Flavors Available

While we don’t exactly know when C4 Neuro will hit the market, though we expect it anytime soon. We do know at least two of the flavors that the 30 serving tubs will come in: Blue Razz and Watermelon.

Wrap Up

C4 Neuro is another great addition to the ever-expanding C4 lineup. If you’re a fan of nootropics in your pre workouts (and who isn’t) then this is right up your alley.

But it’s still going to come down to that proprietary blend dose, something none of us know. For that reason, we’re going to wait for some sales and price drops before buying it and seeing if it belongs in the focus section of our best preworkout guide.

Either way, for you C4 lovers, the next time you have trouble getting “in the zone” for your working or “feeling” your muscles working, it may be worth giving this a shot to get out of your current pre workout rut.

Now, we just need to figure out when this puppy is going to have some incredible price drops that the C4 family is so well-known for on PricePlow…

Cellucor C4 Neuro - Deals and Price Drop Alerts

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References

  1. Hill, CA et al.; Amino Acids; “Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity ;” February 2007
  2. Baguet, A et al.; Journal of Applied Physiology; “Important role of muscle carnosine in rowing performance;” July 2010;” 2005
  3. Roger C. Harris; et al.; “The effect of a supplement containing β-alanine on muscle carnosine synthesis, ventilatory threshold and exercise capacity in Korean cyclists, during 12 weeks combined endurance and weight training
  4. Kendrick IP, et al. The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids. (2008)
  5. Larsen, F; Effects of dietary nitrate on oxygen cost during exercise.; Department of Physiology and Pharmacology, Karolinska Institutet; 2007
  6. Bailey, S; Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans.; School of Sport and Health Sciences, Univ. of Exeter; 2009
  7. Fulford, J; Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions.; NIHR Exeter Clinical Research Facility, University of Exeter Medical School; 2013
  8. MacAllister, R; Arginine and nitrate tolerance; Centre for Clinical Pharmacology, The Rayne Institute, University College London; 2000
  9. Vermeulen, RC, et. al; “Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome“; Psychosomatic Medicine; March-April 2004
  10. Sachan DS, Hongu N; Increases in VO2max and metabolic markers of fat oxidation by caffeine, carnitine, and choline supplementation in rats . J Nutr Biochem. (2000)
  11. http://www.ncbi.nlm.nih.gov/pubmed/22071706
  12. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise.
  13. Alpha-Glycerylphosphorylcholine administration increases the GH responses to GHRH of young and elderly subjects.
  14. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine.
  15. http://www.ncbi.nlm.nih.gov/pubmed/23441963
  16. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217361/
  17. Smith C1; The effects of Sceletium tortuosum in an in vivo model of psychological stress . J Ethnopharmacol. (2011)
  18. Zhao, Q; Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 2002
  19. Magnusson, I; N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans.; Department of Clinical Physiology, Karolinska Institute, Huddinge Hospital; 1998
  20. Deijen, J; Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course.; Department of Clinical Neuropsychology, Vrije Universiteit; 1999
  21. Neri, D; The effects of tyrosine on cognitive performance during extended wakefulness.; Naval Aerospace Medical Research Laboratory; 1995
  22. Deijen JB, Orlebeke JF; Effect of tyrosine on cognitive function and blood pressure under stress . Brain Res Bull. (1994)
  23. Dollins AB, et al; L-tyrosine ameliorates some effects of lower body negative pressure stress . Physiol Behav. (1995)
  24. Li, W; Theacrine, a purine alkaloid obtained from Camellia assamica var. kucha, attenuates restraint stress-provoked liver damage in mice.; Institute of Traditional Chinese Medicine and Natural Products, Jinan University; 2013
  25. Cauli, O; Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release.; Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari; 2008
  26. Feduccia, A; Locomotor activation by theacrine, a purine alkaloid structurally similar to caffeine: involvement of adenosine and dopamine receptors.; Ernest Gallo Clinic and Research Center, University of California at San Francisco; 2012
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