In the wide ranging spectrum of nutritional supplements, perhaps no other category is more well-known, or heavily scrutinized, than fat burners. You have the effective ones that use ingredients shown to aid fat loss, and then the “others” that end up being nothing more than an over-priced bottle of caffeine.
Muscle Elements is one of those companies who makes a truly effective fat burner. 212° is a thermogenic fat loss aid that won’t just help “burn” the fat away, it’ll boil it!
Everyone loves to talk about ME’s pre workout, PreCre, and their upcoming sleep and recovery supplement, Amino PM, but 212° often gets lost in the shuffle. That’s a shame and we hope to change it, because 212° lives up to its name.
It comes in both pill and powder forms — and that powder flavor is top notch!
- One capsule dose (175mg caffeine)
- Higher dose of yohimbine (5mg)
- Solid dose of stimulant-boosting octopamine (100mg)
- Diuretic components added
- Both pill and powder options available
Before we go into detail about the various lipolytic agents in 212°, take a second to sign up for PricePlow alerts and check the best deal:
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Rarely do we see fat burners that are openly dosed as most companies prefer to keep their “secret” blends a trade secret. Muscle Elements swats that notion away and keeps the transparent dosing that we’ve seen with all of the other products.
Note that the serving sizes below are for just one capsule! Also note that we’re focusing on the capsules here – the powder form has some slightly different variations – both labels are shown below to compare:
Thermogenic & Nootropic Amplifier Elements
Caffeine Anhydrous (175mg)
No thermogenic fat loss agent worth its salt is complete without caffeine and 212° doesn’t disappoint. It’s been shown over and over again to be effective for fat loss, energy, focus, and mood improvement.[1,2,3,4]
However, if caffeine was all that was required to burn fat, all those coffee addicts lining coffeehouses would look like magazine cover models. Caffeine is just the start, and this is a great amount to get things rolling, but there is much more ahead!FYI: The powder form has 200mg caffeine per scoop.
Synephrine HCl (30mg)
Synephrine is an alkaloid quite similar to 2000’s favorite banned fat burner, ephedrine. It can increase the thermic effect of food, meaning your body will burn extra calories just digesting the food you eat.
Synephrine also acts as a potent Beta 2 and Beta 3 agonist in the body.[6,7] This is a very good thing to have in a fat burner as it triggers the release of triglycerides where they can be used for energy instead of being stored for fat.
Yohimbine HCl (5mg)
Yohimbine is another naturally occurring alkaloid derived from the Pausinystalia yohimbe tree. It acts as an alpha-2-adrenergic blocking agent that increases noradrenaline release, and may improve alertness and cognition.Yohimbine’s strongest attributes lies in the fat loss and appetite suppression department.
Research demonstrates that supplementing with yohimbine is particularly effective at enhancing lipolysis, increasing appetite control and energy expenditure.[10,11,12]Note that this is a higher-than-average dose of yohimbine for a fat burner. It’s often kept in lower doses (such as around 1-1.5mg) inside of other formulas. The good news is that this will be a lot more effective. However, if you’re sensitive to yohimbine, you’ll want to start with half a scoop of the powder to assess this and then slowly move up.
Vinpocetine is a nootropic compound found in the Periwinkle plant. Similar to CDP-Choline or Alpha GPC, it acts as a stimulant free cognitive enhancer in the body.Vinpocetine boosts brain productivity by increasing cerebral blood flow, which leads to better memory formation, mental processing speed, and cognition.[14,15,16]
Fat Oxidation & Core Temperature Activator Elements
Octopamine HCl (100mg)
Octopamine is a amine found in the human brain that exhibits stimulatory effects similar to its relative, synephrine. Aside from its stim kick, octopamine aids fat burning by preventing glucose uptake by fat cells (adipocytes) by inhibiting the beta-3 adrenoceptors. Furthermore, octopamine activates the alpha-1-adrenergic receptors thereby inducing lipolysis (a.k.a. fat-burning!)A word of warning to all athletes, octopamine is on the WADA banned substances list, so if you’re engaged in collegiate or professional sports, 212 is on your no-no list!
Like the higher dose of yohimbine, this is one of the great difference-makers in 212. For all of the users who love the way this fat burner feels but aren’t sure why… this could very well be one major reason.
Evodiamine 98% (30mg)
Evodiamine functions similarly to capsaicin by stimulating the vanilloids in your body and reducing fat uptake by the cells. It also suppresses circulating levels of caffeine in the body.[20,21]
This will help smooth out the stimulatory effects caffeine, especially if you experience “jitters” when using caffeine or other stims. Finally, evodiamine acts as a mental-booster by improving cognition.
BioPerine® is a patented black pepper (piper nigrum) extract used to increase the bioavailability of various minerals and nutrients and should aid in the absorption of these compounds.
Definition & Tightening Elements
Muscle Elements made another huge distinction against the competition with this group of ingredients – a little bit of diuretic support. These ingredients will help draw some water away from the skin, tightening up the look.It’s especially popular for pre-contest (or pre-vacation) dieters to get that last little bit of shred going, and most fat burners don’t include a blend like this.
Dandelion Extract 20:1 (50mg)
We typically think of dandelion as a weed, but it’s actually possesses a wealth of fat loss benefits. It directly aids weight loss by preventing fat cell differentiation and the accumulation of lipids. Additionally, it may also prevent the absorption of certain carbohydrates. Dandelion will also exert a “drying” effect on the body by acting as a powerful diuretic agent.
Juniper Berry Extract 4:1 (50mg)
Fans of Muscle Elements’ LeanWorks are quite familiar with Juniper Berry. Aside from its use as an ancient medicine and spice, it’s highly regarded for its pro-diuretic effects,[26,27]. This will further “dry” you out and yield the hard and defined look you’ve been after!
Uva Ursi Leaf Extract 20:1 (50mg)
Also known as bear’s grape, Uva Ursi is another plant, and our final ingredient, that helps flush out excess water from the body. It’s long been used for treating infections of the urinary tract, but has also found a way into weight loss supplements as a potent diuretic agent.
Take 1 capsule on an empty stomach upon waking and see how your body reacts to the concoction of stims and diuretic agents. Another capsule may be added after lunch, should you experience no adverse reactions. However, Muscle Elements advises to NOT exceed more than 3 capsules in a 24 hour period!
212° was created for anyone looking to burn unwanted fat, increase mental acuity and enhance their performance in the weight room or on the field. Using a combination of proven fat loss agents and nootropic compounds — at serious doses — 212 will give you a leg up on the competition and have you looking your best whether it’s competition season or bulking season.
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- Backhouse SH, et al. Caffeine ingestion, affect and perceived exertion during prolonged cycling. Appetite. (2011)
- Yoshida T, et al. Relationship between basal metabolic rate, thermogenic response to caffeine, and body weight loss following combined low calorie and exercise treatment in obese women. Int J Obes Relat Metab Disord. (1994)
- Zwyghuizen-Doorenbos A, et al. Effects of caffeine on alertness. Psychopharmacology (Berl). (1990)
- Duncan MJ, Oxford SW. The effect of caffeine ingestion on mood state and bench press performance to failure. J Strength Cond Res. (2011)
- Szemeredi K, et al; Simultaneous measurement of plasma and brain extracellular fluid concentrations of catechols after yohimbine administration in rats . Brain Res. (1991)
- Mizuki Y, et al; Differential effects of noradrenergic drugs on anxiety and arousal in healthy volunteers with high and low anxiety . Prog Neuropsychopharmacol Biol Psychiatry. (1996)
- Galitzky J, et al; Alpha 2-antagonist compounds and lipid mobilization: evidence for a lipid mobilizing effect of oral yohimbine in healthy male volunteers . Eur J Clin Invest. (1988)
- Callahan MF, Beales M, Oltmans GA; Yohimbine and rauwolscine reduce food intake of genetically obese (obob) and lean mice . Pharmacol Biochem Behav. (1984)
- Waluga M, et al; Cardiovascular effects of ephedrine, caffeine and yohimbine measured by thoracic electrical bioimpedance in obese women . Clin Physiol. (1998)
- The effect of an acute infusion of vincamine and ethyl apovincaminate on cerebral blood flow in healthy volunteers
- Filgueiras CC, Krahe TE, Medina AE; Phosphodiesterase type 1 inhibition improves learning in rats exposed to alcohol during the third trimester equivalent of human gestation . Neurosci Lett. (2010)
- Subhan Z, Hindmarch I; Psychopharmacological effects of vinpocetine in normal healthy volunteers . Eur J Clin Pharmacol. (1985)
- Amen DG, et al; Reversing brain damage in former NFL players: implications for traumatic brain injury and substance abuse rehabilitation . J Psychoactive Drugs. (2011)
- Visentin V1, et al. Dual action of octopamine on glucose transport into adipocytes: inhibition via beta3-adrenoceptor activation and stimulation via oxidation by amine oxidases. J Pharmacol Exp Ther. (2001)
- Flechtner-Mors M1, et al. In vivo alpha(1)-adrenergic lipolytic activity in subcutaneous adipose tissue of obese subjects. J Pharmacol Exp Ther. (2002)
- Pearce LV, et al; Evodiamine functions as an agonist for the vanilloid receptor TRPV1 . Org Biomol Chem. (2004)
- Noh K, et al; Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats . Arch Pharm Res. (2011)
- Tsai TH, Chang CH, Lin LC; Effects of Evodia rutaecarpa and rutaecarpine on the pharmacokinetics of caffeine in rats . Planta Med. (2005)
- González-Castejón M1, et al; Reduction of adipogenesis and lipid accumulation by Taraxacum officinale (Dandelion) extracts in 3T3L1 adipocytes: an in vitro study . Phytother Res. (2014)
- Hook I, McGee A, Henman M; Evaluation of Dandelion for Diuretic Activity and Variation in Potassium Content . Pharm Biol. (1993)
- Onal S1, et al; Inhibition of alpha-glucosidase by aqueous extracts of some potent antidiabetic medicinal herbs . Prep Biochem Biotechnol. (2005)
- Beaux D1, Fleurentin J, Mortier F; Effect of extracts of Orthosiphon stamineus Benth, Hieracium pilosella L., Sambucus nigra L. and Arctostaphylos uva-ursi (L.) Spreng. in rats . Phytother Res. (1999)