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Alphamine Reformulated for Better Feels: The Sexiest Supplement

Alphamine has been a fan favorite to many since 2012. As the times and the industry changes, so do formulas. The newest version of Alphamine brings a few tweaks to widen its distribution and appeal to more consumers, while still maintaining itself as the best value cost per serving powder on the market (that 84 serving tub is dense!).

PES Alphamine

PES announced recently that they have reformulated their popular fat burner Alphamine into an energy powder with a much smoother feeling

The changes: The most notable change in the new Alphamine formula is the removal of yohimbine.

No yohimbine? No more anxiety!

From what we’ve gathered, PEScience has removed this ingredient for two reasons:

  1. First, every major international market has banned yohimbine, and it has been causing distribution issues for the company.
  2. Second, the company said after reviewing 4 years of feedback they determined that the number 1 complaint on Alphamine was due to the side effects caused by yohimbine, and the complaints simply far outweighed the praise of yohimbine’s inclusion.

Because Alphamine already has one of the highest per-serving values on the market (averaging $0.42 per serving), the company realized that yohimbine-diehards could simply purchase 90 servings of yohimbine for $8 online, and take it with their Alphamine.

Other less notable changes include swapping out chlorogenic acid for ferulic acid, swapping leucine for HICA, and adding in LCLT, likely for its published human research in combination with choline (which remains in the formula).

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The Alphamine Ingredients

  • Alphamine Proprietary Blend (1,590mg)

    • L-Leucine

      PES Alphamine 2016 Ingredients

      The new version of Alphamine removes the yohimbine, which causes anxiety complaints for too many people and can easily be added back in.

      Where the previous version of Alphamine used the Leucine metabolite HICA as part of its ingredient panel, it’s now been replaced by the branched-chain amino acid (BCAA), L-Leucine.

      Leucine is perhaps the most well studied of the BCAAs and has earned the reputation as “anabolic trigger.”[1] Most of the benefits attributed to BCAA supplementation are most often credited to this vitally important amino acid.

      Leucine activates the mTOR Pathway,[2] which stands for Mammalian Target of Rapamycin, a turbocharged anabolic highway in the body. Having a ready supply of leucine helps prevent atrophy and catabolism. Catabolism is the process where muscles are broken down to supply the required amino acids needed for physiological processes. This happens when there’s no food in your system to turn to, so your body starts degrading its own muscles.[3]

      Alphamine New Formula

      You’d be happy too if you had a nice heavy 84-serving tub of energy!

      Leucine supplementation can prevent this. We have seen as little as 1.8g leucine stimulate MPS, which three scoops of Alphamine/day may get you to or at least very close to.[4]

    • L-Carnitine L-Tartrate

      L-Carnitine supplements have been around for years and years, and used by many. L-Carnitine L-Tartrate (LCLT) is a more bioavailable of the amino acid L-Carnitine.

      LCLT has some strong research showing it’s effective for a more diverse population. LCLT improves endurance and blood flow while reducing damage to muscle fibers from exercise, as well as muscle soreness.[6,7,8]

      Lastly, LCLT increases the density of androgen receptors in muscle cells.[9,10] Basically, this means your anabolic hormones, like testosterone, work more efficiently which translates into more productive workouts.

      It’s our favorite form of L-Carnitine for anyone building muscle, and it’s also usually dosed at 1g per day – which it appears you can get it with 2 scoops of Alphamine throughout your day.

    • Choline Bitartrate

      PES Marie Wold

      PES Athlete Marie Wold may be all smiles with the new version of Alphamine.

      Besides caffeine, this is the lone carryover ingredient from the original Alphamine formula. Choline is a part of the B-vitamin complex and required for optimal body function. However, it’s one of the more difficult vitamins to consume in adequate amounts since it’s only present in significant quantities in a few specific foods such as eggs, chicken, and broccoli[11] (the typical “bro” foods!)

      Choline helps mobilize fat and suppress appetite, but it really shines as a nootropic. It’s a powerful focus enhancer that supports and strengthens the neural communication pathways.[12,13]

      Specifically, choline increases the production of acetylcholine, the neurotransmitter that carries commands between the central nervous system and the skeletal muscle system.[14] This helps foster a stronger “mind-muscle” connection which is necessary if you want to reap as much benefit as possible from your workouts.

      As for its purpose in this formula, at doses achievable with 2 scoops if Alphamine it meets the claims for a 2003 study done on women, showing the combination of choline and LCLT helps to mobilize (break down) fat.[5]

    • L-Theanine

      L-Theanine Tea

      L-Theanine comes from tea leaves, and pairs very well with caffeine offset any potential anxiety — the opposite of what Alphamine and it’s yohimbine used to do for some people!

      Theanine is a non dietary amino acid predominantly found in tea leaves. However, looking around the pre workout and fat burner market, it’s found pretty frequently there as well. The reason is, is that theanine helps smooth out the jarring effects of stimulants, eliminating that “on edge” or jittery feeling.

      Additionally, theanine also enhances the cognitive focus effects of caffeine[15], and alleviates symptoms of stress, anxiety, and fatigue.[16,17]

      This is an ingredient the industry has been adding to supplements more and more lately, and it feels quite good to most users.

    • Ferulic Acid

      Alphamine is now dubbed the “Athlete’s Energy Drink.”, so the inclusion of ferulic acid makes sense, especially with how many users take Alphamine in the pre-workout setting.

      Ferulic Acid is the primary bioactive ingredient in Ferula Asafoetida and a relative newcomer to the world of supplements. Don’t be surprised if this is your first time coming across this one, since we’ve only encountered it in one or two other newer products on the market.

      Various studies have demonstrated that supplementing with as little as 30mg/day yields noticeable improvements in muscle mass, strength, endurance, and recovery.[18,19]

      PES Alphamine Energy Drink

      Honestly, Norcodrene’s change-up doesn’t upset us as much as Alphamine’s did. We wish they would have kept the OG Alphamine and called the new one “Alphamine Lite” or something.

  • Caffeine Anhydrous (125mg)

    There’s not much to mention here that you probably don’t already know. Caffeine is as commonplace in energy drinks, fat burners, and pre workouts as just about anything. It’s a great energy booster, but also helps improve focus, alertness and even enhances fat burning a smidge.

    PEScience is using the same dose here as they did in the previous version of Alphamine, which makes it easily scalable depending on how high your stim tolerance is.

Flavors Available

PES Thermopump Stack

A perfect pre workout combo used to be the ThermoPump Stack.

Along with the formula changes, PES is also expanding Alphamine’s flavor lineup with three additional flavors. In total, there are now seven different flavors to choose how you want your deliciously-flavored caffeine and aminos:

  • Appletini
  • Cotton Candy
  • Fruit Punch
  • Melon Berry Twist
  • Raspberry Lemonade
  • Strawberry Pina Colada
  • Sunrise

The bottles still show 84 servings.

Takeaway

In the past, we’ve dubbed Alphamine “The Sexiest Supplement on the Planet”, and PEScience has done a great job of keeping the brand accessible to everyone. Although they had a fantastic yohimbe extract, the cons just started to outweigh the pros.

PEScience

PEScience changed some of their formulas, but at the end of the day, they’re more popular than ever! Wonder if they’ll release their own yohimbine…

So if you’ve always hated yohimbine or you live outside the USA, good news, you can finally use Alphamine. If you love yohimbine and are sad its gone, don’t fret, you can get a bottle of it for $8 online and add it to Alphamine and still come in below 50 cents per serving.

As for everyone else – you now have a fantastic and delicious energy drink to use first thing in the morning, mid-day, pre workout, or anytime you need a quick jolt and want to avoid eating. Alphamine will no doubt do well, and we are excited to give it another shot. You seriously can’t beat the value with as many scoops as you get here!

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Posts are sponsored in part by the retailers and/or brands listed on this page.

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References

  1. Tipton, K; Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein.; Metabolism Unit, Shriners Hospitals for Children, University of Texas Medical Branch; 2009
  2. Dreyer, H; Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle; Department of Physical Therapy, University of Texas Medical Branch; 2006
  3. Nicastro, H; An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions.; Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo; 2011
  4. Amino acid supplements and recovery from high-intensity resistance training
  5. Carnitine and Choline Supplementation with Exercise Alter Carnitine Profiles, Biochemical Markers of Fat Metabolism and Serum Leptin Concentration in Healthy Women
  6. Volek JS, Judelson DA, Silvestre R, Yamamoto LM, Spiering BA, Hatfield DL, Vingren JL, Quann EE, Anderson JM, Maresh CM, Kraemer WJ. Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults. Am J Cardiol,2008 Nov 15;102(10):1413-7
  7. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc, 2006 Jul;38(7):1288-96
  8. Ho JY, Kraemer WJ, Volek JS, Fragala MS, Thomas GA, Dunn-Lewis C, Coday M, Häkkinen K, Maresh CM.l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism, 2009 Dec 30
  9. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc. 2006 Jul;38(7):1288-96.
  10. Parandak K, Arazi H, Khoshkhahesh F, Nakhostin-Roohi B. The effect of two-week L-carnitine supplementation on exercise -induced oxidative stress and muscle damage. Asian J Sports Med. 2014 Jun;5(2):123-8.
  11. The National Academies Press; “Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline“; Institute of Medicine; 1998
  12. Poly, C, et. al; “The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort“; The American Journal of Clinical Nutrition; December 2011
  13. Diamond, I, et. al; “The relationship of choline acetyltransferase activity at the neuromuscular junction to changes in muscle mass and function“; The Journal of Physiology; January 1974
  14. Diamond, I, et. al; “The relationship of choline acetyltransferase activity at the neuromuscular junction to changes in muscle mass and function“; The Journal of Physiology; January 1974
  15. Giesbrecht, Timo, et al; “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness”; Nutritional Neuroscience; 2010
  16. Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. (2007)
  17. Owen GN, et al. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. (2008)
  18. You, Yanghee, et al. Stimulatory Effects of Ferulic Acid on Endurance Exercise Capacity in Mice.Bioscience, Biotechnology, and Biochemistry 73.6 (2009)
  19. Bucci; Effect of ferulate on strength and body composition of weightlifters. J Appl Sport Sci Res. 1990;4:104–9
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