Alphamine Reformulated (ie Downgraded) for the Masses

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PES Alphamine

PES announced recently that they have reformulated their popular fat burner Alphamine into an “energy drink.” Sadly, we’re viewing this as a downgrade from one of our favorite supplements… but it can now reach a wider market

When PEScience comes out with a new Insider newsletter, it usually signals a massive sale or a brand new product. This time, unfortunately, we got neither. Instead, we were notified of a reformulation of the incredibly popular fat burning energy powder, Alphamine.

We’ll warn you up front, so far the new formula has been universally panned by everyone except the PES reps on various discussion forums, and we agree with the disappointed users. Lots has changed, but the take home message is that the new Alphamine can no longer classified as a “fat burner” by our standards. Because of this we’ll sadly be removing it from its high-ranking status on our Best Fat Burner buyer’s guide.

Before we get to the atrocity that is the new label, take a moment to sign up for alerts from PricePlow and check the best deal:

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In the above widget, there’s no way of telling which stores have the new or old formulas, so look at their ingredient labels or contact them to make sure you’re getting the new one. We’re guessing the old formula (which you can read about here) will be gone by early 2017.

Alphamine 2016 Ingredients

Lots has changed with the new version of Alphamine, and you may not even recognize it when doing a side by side comparison between the old and new labels. Gone are effective ingredients like olive leaf extract, higenamine, and PEScience’s popular SA-2 yohimbe extract.

What we’re left with is flavored caffeine with some amino acids and a bit of focus — more like an energy powder for the masses rather than a serious fat burning powder.

The Alphamine previous formula ingredients

The previous formula ingredients

The Alphamine New Formula Ingredients (2016)

The new formula ingredients. There’s only 0.1g less active product, but it’s an important 0.1g.

The two formulas are side-by-side above, with the new one on the right.

  • Alphamine Proprietary Blend (1,590mg)

    • L-Leucine

      Where the previous version of Alphamine used the Leucine metabolite HICA as part of its ingredient panel, it’s now been replaced by just the basic (yet important) branched-chain amino acid (BCAA), L-Leucine.

      Leucine is perhaps the most well studied of the BCAAs and has earned the reputation as “anabolic trigger.”[1] Most of the benefits attributed to BCAA supplementation are most often credited to this vitally important amino acid.

      PES Alphamine 2016 Ingredients

      The new version of Alphamine removes many of the most important ingredients we used to love in the original. What’s left is what we consider a glorified energy drink.

      Leucine activates the mTOR Pathway[2], which stands for Mammalian Target of Rapamycin, a turbocharged anabolic highway in the body. Having a ready supply of leucine helps prevent atrophy and catabolism.

      Catabolism is the process where muscles are broken down to supply the required amino acids needed for physiological processes. This happens when there’s no food in your system to turn to, so your body starts degrading its own muscles[3].

      While Leucine supplementation can prevent this, usually the amount needed to stimulate muscle protein synthesis and prevent catabolism is 2.5-3g, you won’t get in one, and most likely two scoops, of this new Alphamine.

    • L-Carnitine L-Tartrate

      L-Carnitine supplements have been around for years and years, and used by many. However, the problem with L-Carnitine is that it really provides no tangible benefits unless you’re carnitine deficient, i.e. vegetarians and the elderly.[4,5] L-Carnitine L-Tartrate (LCLT) is a more bioavailable of the the amino acid L-Carnitine.

      LCLT has some strong research showing it’s effective for a more diverse population. LCLT improves endurance and blood flow while reducing damage to muscle fibers from exercise, as well as muscle soreness.[6,7,8]

      Lastly, LCLT increases the density of androgen receptors in muscle cells.[9,10] Basically, this means your anabolic hormones, like testosterone, work more efficiently which translates into more productive workouts.

      It’s our favorite form of L-Carnitine for anyone building muscle, but it’s also usually dosed at 1g per day – possible you can get it with a few scoops of Alphamine throughout your day.

    • Choline Bitartrate

      PES Marie Wold

      PES Athlete Marie Wold may be all smiles with the new version of Alphamine, but we are quite disappointed.

      Besides caffeine, this is the lone carryover ingredient from the original Alphamine formula. Choline is a part of the B-vitamin complex and required for optimal body function. However, it’s one of the more difficult vitamins to consume in adequate amounts since it’s only present in significant quantities in a few specific foods such as eggs, chicken, and broccoli[11] (the typical “bro” foods!)

      Choline helps mobilize fat and suppress appetite, but it really shines as a nootropic. It’s a powerful focus enhancer that supports and strengthens the neural communication pathways.[12,13]

      Specifically, choline increases the production of acetylcholine, the neurotransmitter that carries commands between the central nervous system and the skeletal muscle system.[14] This helps foster a stronger “mind-muscle” connection which is necessary if you want to reap as much benefit as possible from your workouts.

    • L-Theanine

      Theanine is a non dietary amino acid predominantly found in tea leaves. However, looking around the pre workout and fat burner market, it’s found pretty frequently there as well. The reason is, is that theanine helps smooth out the jarring effects of stimulants, eliminating that “on edge” or jittery feeling.

      Additionally, theanine also enhances the cognitive focus effects of caffeine[15], and alleviates symptoms of stress, anxiety, and fatigue.[16,17]

      This is an ingredient the industry has been adding to supplements more and more lately, and it feels quite good to most users.

    • Ferulic Acid

      PES Alphamine Energy Drink

      Alphamine is now dubbed the “Athlete’s Energy Drink.” But… we are athletes… and we want the old formula to stay

      Ferulic Acid is the primary bioactive ingredient in Ferula Asafoetida and a relative newcomer to the world of supplements. Don’t be surprised if this is your first time coming across this one, since we’ve only encountered it in one or two other newer products on the market.

      Various studies have demonstrated that supplementing with as little as 30mg/day yields noticeable improvements in muscle mass, strength, endurance, and recovery.[18,19]

      Of all the changes in Alphamine, this is the one worth getting excited about.

  • Caffeine Anhydrous (125mg)

    There’s not much to mention here that you probably don’t already know. Caffeine is as commonplace in energy drinks, fat burners, and pre workouts as just about anything. It’s a great energy booster, but also helps improve focus, alertness and even enhances fat burning a smidge.

    PEScience is using the same dose here as they did in the previous version of Alphamine, which makes it easily scalable depending on how high your stim tolerance is.

Flavors Available

PES Thermopump Stack

A perfect pre workout combo used to be the ThermoPump Stack. Now, after the Alphamine reformulation, you won’t have much “thermo” component to your pump pre workout.

Along with the formula changes, PES is also expanding Alphamine’s flavor lineup with three additional flavors. In total, there are now seven different flavors to choose how you want your powdered caffeine:

  • Appletini
  • Cotton Candy
  • Fruit Punch
  • Iced Tea
  • Raspberry Lemonade
  • Strawberry Pina Colada
  • Sunrise

The bottles still show 84 servings.

Takeaway

Not really impressed by the new formula? You’re not alone. To be honest, this one breaks our hearts a bit, and we wish they would have kept the original and made this into a separate ‘lite’ product for whoever they’re going to market this to.

In the new literature that accompanies Alphamine, PEScience likens it to a latte’ and an energy drink. That’s basically what they’ve diluted a once great fat burner into.

Why oh why?

Confused Panda

Why would PES reformulate an incredibly popular fat burner into a fairly standard energy drink? We don’t know either…

Why was this move done? No one really knows, but we have a few guesses:

First, yohimbe is also illegal in several countries (due to being an aphrodisiac!), which makes it hard to sell internationally. A separate formulation is often required for fat burners that want to go global… but PEScience clearly wanted to avoid that, so they removed it for everyone, which bums us out.

We also suspect that it might have to do with fear of higenamine soon being under the FDA crosshairs, where the ingredient may receive a bans similar to picamilon. Now we’re down two good fat burning ingredients.

Another possibility is that this is a cost-cutting move by PES to swap out expensive ingredients for cheaper ones, thereby increasing their profit margin. Most fat burning powders have 30 or 60 servings, whereas Alphamine’s always had 84 – the little tub is heavy and we’ve always loved that!

And finally, another consideration is that they simply want to go more “mainstream” by getting away from edgy ingredients like yohimbe, going after the lucrative soccer moms and sorority girl market. Will we see this in Target? If so, that’s great for them, but we won’t be buying it.

Whatever the reason is, we’re just not fans, and it will no longer be on our Top Fat Burner guide.

The Athlete’s Energy Drink?

The marketing now says “The Athlete’s Energy Drink!”, but we’ll stick to our favorite two “energy aminos” products, Off the Chain or EVL BCAA Energy, in those cases…

So if you’re a fan of the original formula like we are (were?), stock up now, because it won’t be around much longer after stores sell out of stock – probably sometime early 2017.

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New References

  1. Tipton, K; Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein.; Metabolism Unit, Shriners Hospitals for Children, University of Texas Medical Branch; 2009
  2. Dreyer, H; Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle; Department of Physical Therapy, University of Texas Medical Branch; 2006
  3. Nicastro, H; An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions.; Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo; 2011
  4. Carnitine status of lactoovovegetarians and strict vegetarian adults and children>
  5. Carnitine function and requirements during the life cycle
  6. Volek JS, Judelson DA, Silvestre R, Yamamoto LM, Spiering BA, Hatfield DL, Vingren JL, Quann EE, Anderson JM, Maresh CM, Kraemer WJ. Effects of carnitine supplementation on flow-mediated dilation and vascular inflammatory responses to a high-fat meal in healthy young adults. Am J Cardiol,2008 Nov 15;102(10):1413-7
  7. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc, 2006 Jul;38(7):1288-96
  8. Ho JY, Kraemer WJ, Volek JS, Fragala MS, Thomas GA, Dunn-Lewis C, Coday M, Häkkinen K, Maresh CM.l-Carnitine l-tartrate supplementation favorably affects biochemical markers of recovery from physical exertion in middle-aged men and women. Metabolism, 2009 Dec 30
  9. Kraemer WJ, Spiering BA, Volek JS, Ratamess NA, Sharman MJ, Rubin MR, French DN, Silvestre R, Hatfield DL, Van Heest JL, Vingren JL, Judelson DA, Deschenes MR, Maresh CM. Androgenic responses to resistance exercise: effects of feeding and L-carnitine. Med Sci Sports Exerc. 2006 Jul;38(7):1288-96.
  10. Parandak K, Arazi H, Khoshkhahesh F, Nakhostin-Roohi B. The effect of two-week L-carnitine supplementation on exercise -induced oxidative stress and muscle damage. Asian J Sports Med. 2014 Jun;5(2):123-8.
  11. The National Academies Press; “Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline“; Institute of Medicine; 1998
  12. Poly, C, et. al; “The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort“; The American Journal of Clinical Nutrition; December 2011
  13. Diamond, I, et. al; “The relationship of choline acetyltransferase activity at the neuromuscular junction to changes in muscle mass and function“; The Journal of Physiology; January 1974
  14. Diamond, I, et. al; “The relationship of choline acetyltransferase activity at the neuromuscular junction to changes in muscle mass and function“; The Journal of Physiology; January 1974
  15. Giesbrecht, Timo, et al; “The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness”; Nutritional Neuroscience; 2010
  16. Kimura K, et al. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. (2007)
  17. Owen GN, et al. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. (2008)
  18. You, Yanghee, et al. Stimulatory Effects of Ferulic Acid on Endurance Exercise Capacity in Mice.Bioscience, Biotechnology, and Biochemistry 73.6 (2009)
  19. Bucci; Effect of ferulate on strength and body composition of weightlifters. J Appl Sport Sci Res. 1990;4:104–9

Our ORIGINAL Alphamine Write-Up, Before the June 2016 Changes

WARNING: The section below is our original Alphamine article, titled “Alphamine – The Sexiest Supplement on the Planet“. It is kept here for historical purposes. If you can find the supplement with this label, we strongly urge you to buy it while you can!

Can a supplement really be sexy? Alongside your diet and training, the right supplements can certainly help make you sexy.

Everyone has different ideas about what “sexy” really is, but we’re willing to bet that when most people picture their idealized body, there’s a lot of lean muscle showing and not much fat to speak of.

Supplements can also be sexy when they help you get the body you want, don’t “taste like a supplement”, and they do it at an unbelievable value.

That’s what makes Alphamine the sexiest supplement on the planet– proven fat-burning results at an unbeatable price per serving. It’s also what makes it our favorite all-around fat burning product!

Fat Burning Powders

Every morning, first thing in the morning. This is PES Athlete Melina Rae

What Exactly is Alphamine?

If you’re totally new to fat-burning products or just haven’t heard of this particular one yet, Alphamine is a thermogenic powder designed to promote fat loss in tandem with regular exercise and a clean diet.

It’s not a magic powder that burns fat on its own without any effort on your part. It’s important to note that, because the fat burner market is mostly a scummy and poorly regulated place, full of a lot of empty promises. The FDA very rarely steps in when it comes to weight loss aids, so you’ve got a saturated marketplace where dishonest companies are free to make claims that aren’t really backed by scientific testing, or even to cut their products with junk filler. Many of these products are useless, and a few are even outright dangerous!

Alphamine is a different animal, though.

A bit about PES

Alphamine

Ever consider drinking your fat burner? We simply love this stuff. This entire post explains why!

The manufacturer, Physique Enhancing Science (PES or PEScience) had years of prior experience in the thermogenic market with Alpha-T2 (the low-stimulant product that came before Alphamine). They’re a legit company that produces a full range of workout-focused supplements, and they sponsor a number of athletes and professional trainers including Ben Carpenter, who we think has the best Facebook page going right now for fitness and body composition advice backed by proven science.

In short, they’re a company with a very solid track record of using ingredients backed by sports nutrition research — not the latest sham “miracle berry” being sold by Dr. Oz — and

Why We Like It

Alphamine is PES’s amplified (and deliciously flavored) tweak on their Alpha-T2 formula, with a bunch of new benefits. The additions to the formula all have solid studies from reputable sources standing behind them.

The main reason we like it is that it just works. Our own in-house reviews of it showed excellent results, and user reviews from around the Internet reflect that same experience.

Just being so effective would be good enough by itself, but there’s some nice bonuses that take it from “like it” to “love it” status with us:

  • A whopping 84 servings

    One is the value — even though Alphamine is more effective than the rest of the fat burning field, you get more servings for the money than usual. You really notice the difference in weight when you pick up your first tub of it.

  • It’s fantastically delicious

    Alphamine Review

    What powers you?

    The flavors are also all great, which is a tough thing to pull off with powdered thermogenics. Stimulants taste bad, to say the least, and the best fat burners do have safe blends of stims.

    We generally prefer a powder to a pill as it’s easier to control your own dosages, especially when it’s a product like this that has a quality blend of stimulants… but it’s gotta taste good, and PES Alphamine does just that.

  • It crushes your morning coffee

    And if you’re accustomed to drinking your caffeine in the morning but want to get off of tooth-staining coffee (or just want something that has much more benefit to your body composition), Alphamine makes for a painless way to switch that isn’t loaded with tons of sugar and other questionable ingredients like your standard “energy drink.”

You Said Something About Reviews?

You don’t need to take our word alone — although you can if you want to, since we’ve done our own hands-on review with our in-house bodybuilder CJ Woodruff and Dylan and Missy from “Dylan and Missy Do Fitness.”

Alphamine has been doing very well for itself in other communities, though. It’s currently sitting at an unheard-of 9.7/10 average among reviewers on Bodybuilding.com.[1] No product stays that high after being out for so long!

The independent supplement analysis and review site SupplementReviews gave it an 8.4 overall score, which puts it at #3 out of 87 thermogenic products rated by the site.[2] The SR guys are clearly a bit harder to please on their number scale, but the results are the same – it’s a top tier supplement.

Two other independent sources gave it very positive reviews: the Australia-based MrSupplement and the podcast SuppTalk, the latter of which voted it their best thermogenic of 2013.[3,4] Amazon’s users also have it at a 4 to 4.5/5 average rating varying by flavor (with Cherry Limeaid currently leading the pack). Amazon often has the best price, but not always, as you can see below:

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So What’s In It? The Alphamine Ingredients

Alphamine Ingredients

The Alphamine Ingredients

Alphamine’s main thermogenic tag team is the combination of caffeine and higenamine. But there’s also synergy with yohimbe, chlorogenic acid, choline and olive leaf extract, plus HICA to keep muscle tissue from breaking down. It’s a nice combo of proven thermogenic and lipolytic agents with amino acid support to keep your muscles from breaking down while dieting.

Let’s take a more detailed look at what makes it work:

  • Caffeine Anhydrous

    We may as well start with caffeine, since you’ll find it in almost every good fat burner out there. And there’s good reason for that — it’s the most inexpensive, safest, reliable and well-studied energy booster there is.[5]

    As the label shows, there’s 125mg of caffeine per serving in Alphamine. That’s roughly the amount in one cup of coffee, and is a great dosage for a serving – right in the middle of the road of most fat burners. Since it’s a powder, you can easily measure out more if you have a high tolerance for it, but there are other stimulants alongside.

    Aside from the well-known energy boost, caffeine is also a thermogenic in its own right, raising core temperature and the potential to burn more calories with exercise. However, by itself it’s only a mild thermogenic — not enough to make any kind of noticeable difference in your workout even at high doses.[6] When you pair it with the next ingredient, however…

  • Higenamine HCl

    Higenamine

    Higenamine activates beta-2 adrenoreceptors nearly as well as synephrine, but has less side effects, as shown by the studies cited to the left

    When ingested, higenamine activates both the beta-1 and the beta-2 adrenergic receptors. This in turn raises the heart rate and releases a bit of adrenaline, which then in turn mobilizes body fat for use as fuel. And the caffeine accelerates the whole process, mobilizing even greater amounts of stored fat.[7,8]

    So what is higenamine? It’s a natural compound found in lotus seeds and a number of different fruits, roots, stems and vines. It has a similar weight loss effect as is seen with ephedrine and  synephrine, but with none of the dangerous side effects. In fact, it’s very well-studied and has proven to be very safe.[9,10]

    This is one of our favorite fat burning ingredients – it’s definitely thermogenic (heat producing) and gets you going, but not to the “scary” extent that some similar ingredients are.

  • Pausinystalia Yohimbe (Bark) Extract (SA2-A)

    Yohimbe has a dual purpose — it inhibits fat storage by blocking alpha-2 adrenergic receptors, keeping it in free circulation as an available source of energy, and it also helps to suppress appetite (especially when taken on an empty stomach, like first thing in the morning).[11]

    The key to yohimbe is the quality of the extract. Yohimbe is a plant native to Africa, and the good stuff comes from the bark. But there’s a range of 30 different beneficial alkaloids that give yohimbe its unique properties, and not all alkaloids are found in all versions of the plant. So extracts that aren’t made properly (or even worse, that don’t come from the bark) are pretty much useless.[12]

    The patented SA-2 extract comes from the “pausinystalia” variety of yohimbe, and is by far the cleanest and purest extract on the market.

    If you’re extremely yohimbe sensitive, you might still want to watch out, and start with a very small dose, such as ¼ scoop, to assess. If you like yohimbe already, you’re going to love Alphamine.

    PES Alphamine

    Are you beach-ready? This is another shot from Melina Rae

  • Choline Bitartrate

    Choline bitartrate also contributes to both the mobilization of fat and appetite suppression. But its real power is as a nootropic. It’s a powerful focus enhancer that actually tunes up the central nervous system by reinforcing neural communication pathways.[13,14]

    Choline is actually a part of the B-vitamin complex and is necessary for regular body function, but it’s one of the tougher vitamins to get enough of as it’s only present in significant quantities in a few specific foods such as eggs, chicken, broccoli and cod.[15]

    PEScience Alphamine

    Choline is the reason you’re so productive with PEScience Alphamine

    The specific benefit to supplementation is that an abundance of it in the body increases the production of acetylcholine, the neurotransmitter that carries commands between the central nervous system and the skeletal muscle system.[14] This neurotransmitter boost translates into increased focus and motivation — just what you need when you’re in a diet and suffering from the infamous “brain fog.”

    If you use it before working out (which is definitely a great idea with Alphamine), you’ll also feel a great “mind-muscle” connection, and have better focus on your muscle contractions, which will lead to a more productive workout.

    One other big benefit of choline is liver support. Aside from helping the liver purge toxins, this can also aid in weight loss as an uptick in liver efficiency has been tied to faster and more effective processing of fats in the system.[16]

  • Alpha-Hydroxy-Isocaproic Acid (HICA)

    HICA is great stuff. This is the ingredient included to ensure you’re not shredding muscle tissue while you’re also shedding fat. To make that work, you need a pretty good dose of it, which is why we love the fact that Alphamine is a powder – you can fit in awesome stuff like this whereas pill-based fat burners can’t (unless you want to swallow 6-8 pills).

    HICA is a metabolite of leucine, which is the most important of the essential amino acids (those that the body can’t produce on its own) when it comes to supporting and building muscle tissue. HICA basically acts as a leucine supplement, but it’s even more concentrated, so you can make sure you’re getting your required daily dose.

  • Keep your muscle tissue

    So why is that so important?

    Alphamine Reviews

    @NavilCarrion shows off her inspiring progress pics!

    Because the body actually prefers not to carry any more than the minimum required muscle tissue around. It costs extra calories per day to maintain, so if the body senses you don’t need it anymore, it’s very quick to strip it out for the wealth of essential amino acids it contains. This tends to be a major problem when you’re on a diet, since you’re usually already running a caloric deficit most days. The key is to get enough protein even when you’re dieting, and supplementing with HICA is a *major* help in hitting those daily leucine macros without tacking on excess calories.

    HICA is anti-catabolic, and it’s also been well-studied in athletes who do intense cardio training regularly. In one study, even when soccer players in training were allowed to eat all the calories they desired, they still shed muscle mass after weeks of intense cardio … but they didn’t when supplementing with HICA![17]

    Even if your primary goal is body fat reduction, it’s still beneficial to put on and maintain muscle mass, because it ups the calories your body automatically burns every day even if you’re completely sedentary. With proper leucine supplementation there’s no reason you can’t both add muscle and burn fat at the same time.

  • Eucommia Ulmoides Leaf (98% Chlorogenic Acid)

    Chlorogenic acid is the central active ingredient in green coffee bean extract, which has been hyped a lot in the supplement world. These supplements actually have a pretty weak track record of actually working, but that isn’t an inherent fault of green coffee bean — the problem is that most of these extracts don’t include enough chlorogenic acid.

    It’s tough to get enough of it from green coffee beans in an economical way, so most manufacturers just include a token amount so they can slap the name on the label. There is a way around this financial conundrum, though — the eucommia ulmoides leaf also happens to be incredibly rich in chlorogenic acid!

    With an adequate amount of chlorogenic acid supplementation, studies have shown weight loss as well as mood improvement and better immune system function.[18,19]

    Eucommia extract appears to also function even more effectively as a lipolytic agent — early studies have shown that it attaches to androgen receptors and stimulates the release of fatty tissue for burning as energy.[20]

  • Olive Leaf Extract

    Olive Leaf Extract

    Olive Leaf Extract brings a ton of benefits and is more and more popular in fat burners lately

    There’s been great interest in the health properties of the olive over the years since people who eat Mediterranean diets have been shown to live longer and have better cardiovascular health on average.[21]

    There’s even some studies that indicate that olive oil compounds can act as a lipolytic agent by increasing adrenaline and noradrenaline.[24]

    Recent studies have really narrowed in on one particular compound in olive oil, however — oleuropein. This compound is directly linked to nearly every health benefit in olive oil. But it’s actually the olive leaf that is the richest source of oleuropein. Among other benefits, the compound is linked to lower overall cholesterol, lower blood pressure and improvements in insulin sensitivity.[22,23,24]

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How To Use It

Alphamine is specifically formulated to be customizable, since everyone has different thresholds and preference levels for their stimulants.

PES’s general recommendation is to take a dose first thing in the morning, as you’ll see increased thermogenic and lipolytic effects on an empty stomach. Beyond that, the recommended maximum is three total scoops per day, but you’re free to divvy those up pretty much however you care to. If you’re not sure where to start, even doses is probably the best bet both for adjusting to the stim blend and for feeling focused and motivated throughout the day.

Alphamine Fat Burner

PES Athlete Alzira Rodriguez shows her favorite thermogenic

Are There Side Effects?

For certain people, there may be. It’s going to depend on your sensitivity to yohimbe.

While yohimbe is usually well-tolerated in humans, some people (roughly 1% of users) are sensitive to it and may experience anxiety, stomach discomfort or flushing.[25,26,27,28]

If you’re extremely sensitive to other stimulants such as caffeine, there’s a good chance yohimbe will also a strong effect.

Yohimbe

A yohimbe tree. Its bark has some incredible fat burning and appetite suppressant properties, but some people can’t take too much. SA2-A is a very very clean extract, but if you’re sensitive, you must start at a very light dosage

At Alphamine’s dosage there’s nothing truly dangerous to worry about however, just potential discomfort for those who are sensitive. Start with a very small quarter-dose to assess tolerance, then move up if you feel OK.

It’s worth noting that of the potential side effects cited above, most issues reported are from massively excessive abuse – whether it’s an extreme dose (not recommended) or someone mixing with a platitude of other stimulants like ephedrine (also not recommended unless you really know what you’re doing and use low doses of each).

Yohimbe is also contraindicated with many neurological medications. If you’re taking any sort of prescription medication, it’s best to consult with your doctor before starting in on Alphamine.

If you’re new to thermogenics, an increase in body temperature and general feeling of “hotness” with possible sweating is not uncommon. This is a normal effect for something this potent and is a sign it’s doing what it’s supposed to!

Appetite suppression – especially when using it on an empty stomach – is definitely a “side effect”, but it’s an intended one. Almost everyone using Alphamine is in diet mode, and appetite suppression is extremely helpful.

The label has the usual legal CYA disclaimer about not taking it if you’re pregnant, nursing, or under the age of 18. Alphamine should be avoided with certain prescription medications, however, most notably treatments for high blood pressure, abnormal heart rate, kidney or thyroid disease, seizure disorders,diabetes, enlarged prostate, or monoamine oxidase inhibitors.

Bringin’ The Sexy Back!

To sum it all up, Alphamine delivers proven fat loss by way of effective, well-studied ingredients. That would be good enough by itself, but what really seals the deal for us are the delicious flavors and excellent value per serving.

It’s one of the most affordable thermogenic powders on the market yet also one of the most effective and best-tasting. How do you beat all that?

Just remember, Alphamine is the nitrous oxide, not the gasoline. You can’t just swig it in the morning and expect instant results. But if you:

  1. Keep to a regular exercise regimen
  2. Eat clean, carefully count calories and macronutrients and weigh your food
  3. Take in adequate (100g per day or better) protein along with healthy fats and dietary fiber

… then Alphamine will definitely accelerate your fat loss. Sexy stuff.

Where Do I Buy It?

We happen to run this thing called the Priceplow Engine that will find the best current prices for you, including temporary price drops, clearance sales and with any available coupon codes rolled right into the displayed price!

You can buy Alphamine by mail direct from PEScience, but their list price is almost always $8 to $11 higher than it is at the retail supplement stores that we list here.

Alphamine

We simply love this stuff. This entire post explains why!

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References

  1. https://www.priceplow.com/out/849173
  2. supplementreviews.com/pes/alphamine
  3. mrsupplement.com.au/alphamine-review
  4. https://www.facebook.com/pescience/posts/661661340562582
  5. Nehlig A, et. al.; “Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects“; Brain Research; 1992
  6. Acheson, K, et. al.; “Metabolic effects of caffeine in humans: lipid oxidation or futile cycling?“; American Journal of Clinical Nutrition; January 2004
  7. Kang, YJ, et. al.; “Inhibition of activation of nuclear factor kappaB is responsible for inhibition of inducible nitric oxide synthase expression by higenamine, an active component of aconite root“; The Journal of Pharmacology and Experimental Therapeutics; October 1999
  8. Bai, G, et. al.; “Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist“; Acta Pharmacologica Sinica; October 2008
  9. Kimura, I, et. al.; “Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria“; Japanese Journal of Pharmacology; September 1994
  10. Feng, S, et. al.; “A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects“; Acta Pharmacologica Sinical; November 2012
  11. Ostojic, SM; “Yohimbine: the effects on body composition and exercise performance in soccer players“; Research in Sports Medicine; October-December 2006
  12. Betz, JM, et. al; “Gas chromatographic determination of yohimbine in commercial yohimbe products“; Journal of AOAC International; September-October 1995
  13. Poly, C, et. al; “The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort“; The American Journal of Clinical Nutrition; December 2011
  14. Diamond, I, et. al; “The relationship of choline acetyltransferase activity at the neuromuscular junction to changes in muscle mass and function“; The Journal of Physiology; January 1974
  15. The National Academies Press; “Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline“; Institute of Medicine; 1998
  16. http://lpi.oregonstate.edu/infocenter/othernuts/choline/
  17. Mero, AA, et. al; “Effects of alfa-hydroxy-isocaproic acid on body composition, DOMS and performance in athletes“; Journal of the International Society of Sports Nutrition; January 2010
  18. Cropley, V, et. al; “Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study“; Psychopharmacology; February 2012
  19. Watanabe, T, et. al; “The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension“; Clinical and Experimental Hypertension; July 2006
  20. Ong, Victor, et. al; “Novel phytoandrogens and lipidic augmenters from Eucommia ulmoides“; BMC Complementary and Alternative Medicine; January 2007
  21. Salvucci, Angelo; “Literature Review: Mediterranean Diet & Cardiovascular Health“; EMS World; November 2013
  22. Susalit, E, et. al; “Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril“; Phytomedicine; February 2011
  23. de Bock, M, et al; “Olive (Olea europaea L.) leaf polyphenols improve insulin sensitivity in middle-aged overweight men: a randomized, placebo-controlled, crossover trial“; PloS One; March 2013
  24. Shen, Y, et al; “Olive Leaf Extract Attenuates Obesity in High-Fat Diet-Fed Mice by Modulating the Expression of Molecules Involved in Adipogenesis and Thermogenesis“; Evidence-Based Complementary and Alternative Medicine; January 2014
  25. Kearney T; Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases . Ann Pharmacother. (2010)
  26. Linden CH; Yohimbine: a new street drug; Ann Emerg Med. (1985)
  27. HOLMBERG G, GERSHON S; Autonomic and psychic effects of yohimbine hydrochloride; Psychopharmacologia. (1961)
  28. Giampreti A, et al; Acute neurotoxicity after yohimbine ingestion by a body builder; Clin Toxicol (Phila). (2009)

Wasn’t there an Alphamine Recall?

Alphamine was recalled in November 2013 after the FDA warned that an ingredient may not be considered a dietary ingredient. To be proactive with the FDA’s viewpoints, Alphamine issued a voluntary recall. No adverse events have been reported with the supplement.

Posted in by Mike | Tagged , , , , , , , , , , , , , , .
  • Veix

    Too bad that European version has Pausinystalia Yohimbe (Bark) Extract (SA2-A) removed the formula :(

  • Why PES WHY, this is Norcodrone.

  • Takao Hiroyuki

    All these PES sponsored “athletes” on Instagram started posting ‘ooooh I’m so glad PES removed Yohimbine.It gives me nausea!’ when they were all promoting the original Alphamine ‘I love Alphamine, PES uses SA2A which doesnt give me any side effects’.

  • Romulo

    Hard to believe they simply destroied such a great fat burner! By the way, Norcodrene was also changed… and also for the way worse… Probably, PricePlow will remove it from the top 10 too